| Drug,Description
|
| DB09000,"Cyamemazine (Tercian), also known as cyamepromazine,"
|
| DB06261,In vitro studies have shown increased porphyrin fluorescence in normal urothelium after exposure to hexaminolevulinate hydrochloride intravesical solution.
|
| DB00511,The main pharmacological effects of acetyldigitoxin are on the heart.
|
| DB00821,"Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen."
|
| DB00564,**General effects**Carbamazepine treats seizures and the symptoms of trigeminal neuralgia by inhibiting sodium channels.
|
| DB01174,"Phenobarbital, the longest-acting barbiturate,"
|
| DB00972,"Azelastine antagonizes the actions of histamine,"
|
| DB00812,"Phenylbutazone is a synthetic, pyrazolone derivative."
|
| DB05676,"Apremilast reduces but does not completely inhibit various inflammatory cytokines such as IL-1α, IL-6, IL-8, IL-10 MCP-1, MIP-1β, MMP-3, and TNF-α,"
|
| DB04951,"Pirfenidone is a novel agent with anti-inflammatory, antioxidant, and antifibrotic properties."
|
| DB01283,Lumiracoxib has a different structure from the standard COX-2 inhibitors.
|
| DB00254,Doxycycline and other tetracyclines are mainly bacteriostatic and are thought to exert antimicrobial effects by the inhibition of protein synthesis
|
| DB00374,"As an analogue of prostacyclin, treprostinil promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation ."
|
| DB00784,"Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs)."
|
| DB01254,Dasatinib is an oral dual BCR/ABL and Src family tyrosine kinase inhibitor
|
| DB08991,Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain
|
| DB01250,Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.
|
| DB02709,"Resveratrol, a phytoalexin, has been found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent,"
|
| DB00795,"The mode of action of sulfasalazine or its metabolites,"
|
| DB01097,Leflunomide is a pyrimidine synthesis inhibitor indicated in adults for the treatment of active rheumatoid arthritis (RA).
|
| DB00469,"Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties,"
|
| DB08814,Triflusal is an antithrombotic anticoagulant.
|
| DB00261,Anagrelide decreases platelet counts by suppressing transcription factors necessary for the synthesis and maturation of platelet-producing cells
|
| DB01050,Ibuprofen has multiple actions in different inflammatory pathways involved in acute and chronic inflammation.
|
| DB00586,Diclofenac reduces inflammation and by extension reduces nociceptive pain and combats fever
|
| DB01401,Trisalicylate-choline is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of choline salicylate and magnesium salicylate.
|
| DB09212,"Loxoprofen is a non-selective inhibitor of cyclooxygenase enzymes, which are responsible for the formation of various biologically active pain, fever, and inflammatory mediators."
|
| DB08880,"Teriflunomide is an immunomodulatory agent that decreases the amount of activated CNS lymphocytes,"
|
| DB08984,Etofenamate is used to treat muscle and joint paint.
|
| DB09070,"Tibolone prevents bone loss and treating post-menopausal symptoms without stimulating the endometrial tissues, which may lead to malignancy."
|
| DB08981,"Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis."
|
| DB01240,"Epoprostenol has two major pharmacological actions: (1) direct vasodilation of pulmonary and systemic arterial vascular beds, and (2) inhibition of platelet aggregation."
|
| DB00619,Imatinib is a 2-phenylaminopyrimidine derivative neoplastic agent that belongs to the class of tyrosine kinase inhibitors.
|
| DB09074,Olaparib is a cytotoxic and anti-tumour agent.
|
| DB00246,"Ziprasidone is classified as a ""second generation"" or ""atypical"" antipsychotic and is a dopamine and 5HT2A receptor antagonist with a unique receptor binding profile."
|
| DB05521,Telaprevir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotype 1
|
| DB00289,Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD)
|
| DB09054,"Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL),"
|
| DB08873,Boceprevir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotype 1
|
| DB04573,Estriol (also oestriol) is one of the three main estrogens produced by the human body
|
| DB08912,Dabrafenib is a kinase inhibitor that is mainly used to target BRAF V600E mutation in multiple types of cancer.
|
| DB02703,Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection
|
| DB00378,"Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus."
|
| DB09124,Medrogestone was created as a more potent and orally active option of progesterone.
|
| DB01609,Deferasirox is an orally active chelator that is selective for iron (as Fe3+).
|
| DB00607,Nafcillin is a semisynthetic antibiotic substance derived from 6-amino-penicillanic acid
|
| DB00238,Nevirapine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB01351,A barbiturate with hypnotic and sedative properties (but not antianxiety).
|
| DB00451,"Oral levothyroxine is a synthetic hormone that exerts the same physiologic effect as endogenous T<sub>4</sub>,"
|
| DB00279,"In hormonal replacement,"
|
| DB00675,Tamoxifen is a selective estrogen receptor modulator that inhibits growth and promotes apoptosis in estrogen receptor positive tumors
|
| DB06739,Seratrodast (INN) is a thromboxane receptor antagonist used primarily in the treatment of asthma
|
| DB09218,Clonixin is a non-steroidal anti-inflammatory drug (NSAID) similar in structure to .
|
| DB00749,Etodolac is an anti-inflammatory agent with analgesic and antipyretic properties.
|
| DB01076,Atorvastatin is an oral antilipemic agent that reversibly inhibits HMG-CoA reductase.
|
| DB09030,Vorapaxar is a tricyclic himbacine-deriv
|
| DB00370,**General effects and a note on suicidality**Mirtazapine is effective in treating moderate to severe depression and treats many symptoms normally associated with this condition.
|
| DB00569,"Fondaparinux binds specifically to the natural anticoagulant factor, ATIII."
|
| DB08976,Floctafenine is an anti-inflammatory analgesic similar in action to aspirin.
|
| DB00775,"Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack,"
|
| DB04552,"Niflumic acid, a nonsteroidal anti-inflammatory fenamate,"
|
| DB08994,Ditazole is a non-steroidal anti-inflammatory drug (NSAID).
|
| DB04918,"Ceftobiprole, a cephalosporin antibiotic,"
|
| DB08887,Icosapent ethyl or ethyl eicosapentaenoic acid is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA)
|
| DB01166,"Cilostazol reduces the symptoms of intermittent claudication, as indicated by an increased walking distance."
|
| DB00417,Phenoxymethylpenicillin works against penicillin-sensitive microorganisms with bactericidal effects.
|
| DB12598,Nafamostat is a fast-acting proteolytic inhibitor used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin by competitively inhibiting several serine proteases including thrombin
|
| DB09075,"Administration of edoxaban results in prolongation of clotting time tests such as aPTT (activated partial thromboplastin time), PT (prothrombin time),"
|
| DB00498,Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver
|
| DB09288,Propacetamol is hydrolyzed to paracetamol and then it presents a weak inhibition of COX-1 and COX-2 which is translated into a low anti-inflammatory activity.
|
| DB01420,The administration of testosterone propionate can induce production of proteins related to male sexual development.
|
| DB01416,"Cefpodoxime is shown to be effective against most Gram positive and Gram negative bacteria, except <i>Pseudomonas aeruginosa</i>, <i>Enterococcus</i>,"
|
| DB00244,"Mesalazine is one of the two components of sulphasalazine, the other being sulphapyridine."
|
| DB00482,"Celecoxib inhibits cyclooxygenase 2 (COX-2) enzyme, reducing pain and inflammation."
|
| DB00758,Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke
|
| DB06725,Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the oxicam class.
|
| DB00344,Protriptyline is a tricyclic antidepressant.
|
| DB00163,"Vitamin E is a collective term used to describe 8 separate fat soluble antioxidants, most commonly alpha-tocopherol."
|
| DB09093,Tetracycline antibiotics are bacteriostatic agents which act to inhibit bacterial growth and reproduction
|
| DB00540,Nortriptyline exerts antidepressant effects likely by inhibiting the reuptake of serotonin and norepinephrine at neuronal cell membranes.
|
| DB00618,"Demeclocycline is a tetracycline antibiotic active against the following microorganisms: <i>Rickettsiae</i> (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fevers),"
|
| DB01142,"Similar to other tricyclic antidepressants, doxepin was shown, in preclinical trials,"
|
| DB01329,Cefoperazone is a third generation cephalosporin antibiotic
|
| DB00685,Trovafloxacin is a broad spectrum antibiotic that inhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV
|
| DB01155,Gemifloxacin is a quinolone/fluoroquinolone antibiotic.
|
| DB01332,Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms
|
| DB01333,A semi-synthetic cephalosporin antibiotic.
|
| DB00215,Citalopram belongs to a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs).
|
| DB00458,Imipramine is a tricyclic antidepressant with general pharmacological properties similar to those of structurally related tricyclic antidepressant drugs such as amitriptyline and doxepin.
|
| DB09320,It is an antibiotic against penicillin-susceptible microorganisms with bactericidal effect.
|
| DB09323,Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria
|
| DB00839,Tolazamide is an oral blood glucose lowering drug of the sulfonylurea class.
|
| DB08983,Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin.
|
| DB00715,"Paroxetine treats the symptoms of depression, various anxiety disorders, posttraumatic stress disorder, obsessive-compulsive disorder,"
|
| DB01149,"Nefazodone, an antidepressant synthetically derived phenylpiperazine, is used to treat major depression."
|
| DB06710,Testosterone is a steroid hormone from the androgen group.
|
| DB00539,Toremifene is an antineoplastic hormonal agent primarily used in the treatment of advanced breast cancer.
|
| DB01120,"Based on the pharmacological properties,"
|
| DB00263,Sulfisoxazole is a sulfonamide antibiotic.
|
| DB09270,"Ubidecarenon has roles in many prysiological process including sulfide oxidation,"
|
| DB00285,Venlafaxine is an antidepressant agent that works to ameliorate the symptoms of various psychiatric disorders by increasing the level of neurotransmitters in the synapse.
|
| DB01132,"Pioglitazone enhances cellular responsiveness to insulin, increases insulin-dependent glucose disposal, and improves impaired glucose homeostasis."
|
| DB08865,"In a phase I study, 37 patients with a variety of solid-tumor cancers refractory to therapy received 50 to 300 mg of crizotinib daily or twice daily."
|
| DB00648,Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types
|
| DB01167,Itraconazole is an imidazole/triazole type antifungal agent.
|
| DB00257,Clotrimazole is a broad-spectrum antifungal agent that inhibits the growth of pathogenic yeasts by changing the permeability of cell membranes
|
| DB00243,Ranolazine exerts both antianginal and ischemic effects independent from lowering heart rate or blood pressure.
|
| DB06595,"It targets multiple WT and mutated kinases that, when activated,"
|
| DB01264,"Darunavir is an inhibitor of the human immunodeficiency virus (HIV) protease, which prevents HIV viral replication."
|
| DB00270,Isradipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels
|
| DB09065,"Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV)."
|
| DB00622,"Nicardipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
|
| DB01232,Saquinavir exerts its antiviral activity by inhibiting an enzyme critical for the HIV-1 viral lifecycle.
|
| DB01357,The 3-methyl ether of ethinyl estradiol.
|
| DB01033,Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias
|
| DB01259,Lapatinib is a small molecule and a member of the 4-anilinoquinazoline class of kinase inhibitors.
|
| DB01023,"Felodipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs),"
|
| DB01029,Irbesartan is an angiotensin receptor blocker used to treat hypertension and diabetic nephropathy
|
| DB00422,Methylphenidate is a racemic mixture comprised of the d- and l-isomers.
|
| DB06290,"Simeprevir is a direct-acting antiviral agent and inhibitor for HCV NS3/4A protease, which is an important enzyme required for viral replication."
|
| DB00549,"Zafirlukast is a synthetic,"
|
| DB01128,Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer.
|
| DB00717,Norethisterone is a synthetic oral progestin used for contraception or to treat other hormone-related conditions such as menopausal symptoms and endometriosis.
|
| DB04911,"Oritavancin interferes with bacterial cell wall synthesis and integrity, treating susceptible skin and subcutaneous tissue infections with gram-positive bacteria."
|
| DB09330,A pharmacokinetic/pharmacodynamic analysis suggested a concentration-dependent QTc interval prolongation of 14 msec (upper bound of two-sided 90% CI: 16 msec) at a dose of osimertinib 80 mg
|
| DB00688,Mycophenolate mofetil is a prodrug of mycophenolic acid (MPA).
|
| DB00814,"Meloxicam is an anti-inflammatory, analgesic analgesic with antipyretic effects in fever."
|
| DB00963,"Bromfenac ophthalmic solution is a sterile, topical,"
|
| DB06802,"Low but quantifiable plasma concentrations of nepafenac and amfenac were observed in the majority of subjects 2 and 3 hours postdose,"
|
| DB00179,Masoprocol is a novel antineoplastic agent.
|
| DB09215,Droxicam is a prodrug of .
|
| DB00712,"Flurbiprofen, a nonsteroidal anti-inflammatory agent (NSAIA) of the propionic acid class, is structually and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen,"
|
| DB00465,Ketorolac is a non-selective NSAID and acts by inhibiting both COX-1 and COX-2 enzymes which are normally responsible for converting arachidonic acid to prostaglandins
|
| DB01397,Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain.
|
| DB09123,"Dienogest exhibits a very potent progestagenic effect in the endometrium,"
|
| DB00603,"Medroxyprogesterone acetate (MPA) inhibits gonadotropin production, reduces nuclear estrogen receptors and DNA synthesis in epithelial cells of the endometrium,"
|
| DB06789,No specific pharmacodynamic studies have been performed to assess hydroxyprogesterone caproate injections.
|
| DB11636,Nomegestrol is an ingredient in the EMA-authorised product Zoely
|
| DB01600,"Tiaprofenic acid is a non-steroidal anti-inflammatory drug of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain."
|
| DB00233,Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli
|
| DB00573,"Fenoprofen is a propionic acid derivative with analgesic, antiinflammatory and antipyretic properties."
|
| DB00744,Zileuton is an asthma drug that differs chemically and pharmacologically from other antiasthmatic agents.
|
| DB04743,"Food,"
|
| DB01236,Sevoflurane induces muscle relaxation and reduces sensitivity by altering tissue excitability with a fast onset of action
|
| DB00768,Inflammatory reactions in response to various stimuli are mediated by endogenous mediators and other pro-inflammatory factors
|
| DB00932,Tipranavir is a non-peptidic protease inhibitor (PI) of HIV.
|
| DB01009,Ketoprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
|
| DB00554,Piroxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
|
| DB00939,"Meclofenamic acid is a nonsteroidal agent which has demonstrated anti-inflammatory, analgesic,"
|
| DB00991,Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.
|
| DB06730,Gestodene is a progestogen hormonal contraceptive.
|
| DB00691,Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat.
|
| DB00722,"Lisinopril is an angiotensin converting enzyme inhibitor used to treat hypertension, heart failure, and myocardial infarction."
|
| DB00584,Enalapril is an antihypertensive agent that exhibits natriuretic and uricosuric properties.
|
| DB00876,"Angiotensin II, the principal pressor agent of the renin-angiotensin system,"
|
| DB01197,"Captopril, an ACE inhibitor, antagonizes the effect of the RAAS."
|
| DB00492,"Following oral administration, fosinopril is rapidly and completely hydrolyzed to its principle active metabolite, fosinoprilat."
|
| DB00396,"Progesterone, depending on concentration and dosage form, and timing of exposure may have several pharmacodynamic effects."
|
| DB12364,Betrixaban is an oral anticoagulant that excerts its action by preventing thrombin generation without having a direct effect on platelet aggregation
|
| DB00615,Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells.
|
| DB01320,Fosphenytoin is a water-soluble phenytoin prodrug used for the treatment of epileptic seizures.
|
| DB01201,Rifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells.
|
| DB05266,Ibudilast is an anti-inflammatory and ne
|
| DB01399,Salsalate is a nonsteroidal anti-inflammatory agent for oral administration.
|
| DB06737,A non-steroidal anti-inflammatory drug approved for use in Japan in 1993
|
| DB00975,"Dipyridamole, a non-nitrate coronary vasodilator that also inhibits platelet aggregation, is combined with other anticoagulant drugs, such as warfarin,"
|
| DB00946,"Phenprocoumon, a coumarin anticoagulant,"
|
| DB09216,Studies have shown that tolfenamic acid presents a non-dose dependent partial inhibition of irritant-induced temperature rise as well as a dose-dependent inhibition of skin edema
|
| DB00210,"Adapalene is anticomedogenic, preventing the formation of new comedones and inflammatory lesions, and also acts to reduce inflammation by modulating the innate immune response."
|
| DB00337,Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema).
|
| DB00861,"Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties."
|
| DB00266,Dicumarol is an coumarin-like compound found in sweet clover
|
| DB04272,A key intermediate in metabolism.
|
| DB01418,Acenocoumarol inhibits the reduction of vitamin K by vitamin K reductase.
|
| DB00220,Nelfinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB00582,Voriconazole is a fungistatic triazole antifungal used to treat infections by inhibiting fungal growth.
|
| DB12332,Rucaparib is an anticancer agent that exerts cytotoxic effects against cancer cells.
|
| DB01211,"Clarithromycin is a macrolide antibiotic whose spectrum of activity includes many gram-positive <i>Staphylococcus aureus,"
|
| DB00188,"Bortezomib works to target the ubiquitin-proteasome pathway, an essential molecular pathway that regulates intracellular concentrations of proteins and promotes protein degradation."
|
| DB09118,Stiripentol is an antiepileptic agent that works to reduce seizure frequency.
|
| DB08820,The use of Ivacaftor has been shown to both improve CF symptoms and modulate underlying disease pathology
|
| DB00278,Argatroban is a synthetic direct thrombin inhibitor derived from L-arginine indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia
|
| DB00870,Suprofen is a non-steroidal anti-inflammatory analgesic and antipyretic.
|
| DB09543,"Methyl salicylate relieve musculoskeletal pain in the muscles, joints,"
|
| DB06605,"Apixaban selectively inhibits factor Xa in its free and bound forms, independant of antithrombin III."
|
| DB00328,"Indometacin is an NSAID with analgesic and antipyretic properties that exerts its pharmacological effects by inhibiting the synthesis of factors involved in pain, fever,"
|
| DB09084,Benzydamine is a non-steroidal anti-inflammatory drug (NSAID) designed to elicit local anesthetic and analgesic effects mainly for the mouth and throat
|
| DB00461,"NSAIDs, like nabumetone, are well established as analgesics."
|
| DB00255,Diethylstilbestrol is a synthetic estrogen that was developed to supplement a woman's natural estrogen production.
|
| DB00977,"Ethinylestradiol is a synthetic estrogen that decreases luteinizing hormone to decrease endometrial vascularization,"
|
| DB09211,Limaprost produces vasodilation to improve blood flow to the extremities and increase cutaneous temperature
|
| DB08954,"N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family,"
|
| DB07615,Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals.
|
| DB00945,**Effects on pain and fever**Acetylsalicylic acid disrupts the production of prostaglandins throughout the body by targeting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) .
|
| DB00806,"Pentoxifylline, a synthetic dimethylxanthine derivative structurally related to and , exhibits hemorheological, anti-oxidative,"
|
| DB08797,"Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl."
|
| DB00735,"Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative."
|
| DB09053,In vitro studies have shown an induction of CLL cell apoptosis even in presence of prosurvival factors
|
| DB01171,"A selective, reversible inhibitor of monoamine oxidase (MAO) which increases the ."
|
| DB00908,"Quinidine is an antimalarial schizonticide, and a class Ia antiarrhythmic agent used to interrupt or prevent reentrant arrhythmias and arrhythmias due to increased automaticity, such as atrial flutter,"
|
| DB00375,"Cholesterol is the major, and probably the sole precursor of bile acids ."
|
| DB00415,"Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
|
| DB00794,"Primidone alters sodium and calcium channel transport, reducing the frequency of nerve firing,"
|
| DB00673,"Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which,"
|
| DB01220,"Rifaximin is a structural analog of rifampin and a non-systemic, gastrointestinal site-specific antibiotic."
|
| DB00559,Bosentan belongs to a class of drugs known as endothelin receptor antagonists (ERAs).
|
| DB01208,Sparfloxacin is a synthetic fluoroquinolone broad-spectrum antimicrobial agent in the same class as ofloxacin and norfloxacin.
|
| DB00923,Ceforanide is a semisynthetic second-generation cephalosporin.
|
| DB01098,"Rosuvastatin is a synthetic, enantiomerically pure antilipemic agent."
|
| DB01039,"Fenofibrate is a fibrate that activates peroxisome proliferator activated receptor alpha (PPARα) to alter lipid metabolism and treat primary hypercholesterolemia, mixed dyslipidemia,"
|
| DB08795,Azidocillin is a penicillin antibiotic similir to ampicillin
|
| DB08804,Nandrolone decanoate is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis
|
| DB11362,"At the maximum tolerated dose of 1600 mcg twice per day,"
|
| DB01000,"Cyclacillin, a penicillin, is a cyclohexylamido analog of penicillanic acid."
|
| DB01059,Norfloxacin is a quinolone/fluoroquinolone antibiotic.
|
| DB00754,Ethotoin is a hydantoin derivative and anticonvulsant.
|
| DB00605,"Sulindac is a non-steroidal anti-inflammatory indene derivative,"
|
| DB08439,Parecoxib is a water-soluble and injectable prodrug of valdecoxib.
|
| DB00602,"Ivermectin is a semisynthetic, anthelminitic agent."
|
| DB00472,"Fluoxetine blocks the serotonin reuptake transporter in the presynaptic terminal, which ultimately results in sustained levels of 5-hydroxytryptamine (5-HT) in certain brain areas."
|
| DB01016,"Glyburide is a second generation sulfonylurea that stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells,"
|
| DB01131,Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil.
|
| DB00543,"Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines."
|
| DB00359,Sulfadiazine is a sulfonamide antibiotic.
|
| DB00591,"Fluocinolone acetonide is a synthetic anti-inflammatory corticosteroid and thus, the effect of its interaction with the body produces vasoconstriction and suppression of membrane permeability,"
|
| DB01212,"Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms."
|
| DB01242,"Clomipramine, a tricyclic antidepressant,"
|
| DB08906,"Systemically, in vitro experiments show fluticasone furoate activates glucocorticoid receptors, inhibits nuclear factor kappa b,"
|
| DB09008,Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin.
|
| DB04576,Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
|
| DB00873,This compound belongs to the class of organic compounds known as androgens and derivatives.
|
| DB01137,Levofloxacin is bactericidal and exerts its antimicrobial effects via inhibition of bacterial DNA replication
|
| DB00240,Alclometasone is a synthetic corticosteroid for topical dermatologic use.
|
| DB01104,"Sertraline improves or relieves the symptoms of depression, OCD, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder,"
|
| DB00253,Medrysone is a topical anti-inflammatory corticoidsteroids for ophthalmic use.
|
| DB00635,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
|
| DB01222,Budesonide is a glucocorticoid used to treat respiratory and digestive conditions by reducing inflammation.
|
| DB06700,Desvenlafaxine is a selective serotonin and norepinephrine reuptake inhibitor.
|
| DB01263,Posaconazole is an antifungal agent structurally related to itraconazole.
|
| DB00304,"The effects of desogestrel are divided on reproductive including modification of luteinizing hormone and follicle stimulating hormone,"
|
| DB01072,Atazanavir (ATV) is an azapeptide HIV-1 protease inhibitor (PI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1)
|
| DB00268,"**Effects on Parkinson's and restless leg syndrome**This drug promotes the relief or improvement of symptoms of Parkinson's or restless leg syndrome by stimulatory actions on dopamine receptors,"
|
| DB00301,"Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
|
| DB00294,Etonogestrel attains its therapeutic effect inhibiting fertility by impairing the release of the luteinizing hormone which is one of the most important reproductive hormones for ovulation.
|
| DB09119,Eslicarbazepine acetate is associated with a dose- and concentration-dependant increase in heart rate and prolongation of PR interval
|
| DB08933,"Luliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum,"
|
| DB00338,**Effects on gastric acid secretion**This drug decreases gastric acid secretion .
|
| DB09238,Manidipine produces vasodilation resulting in lower blood pressure
|
| DB00745,Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy
|
| DB00783,Estradiol acts on the on the estrogen receptors to relieve vasomotor systems (such as hot flashes) and urogenital symptoms (such as vaginal dryness and dyspareunia)
|
| DB01196,Estramustine is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate.
|
| DB01022,"Phylloquinone is a vitamin K indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII,"
|
| DB01127,"Econazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex)."
|
| DB00313,Valproate has been shown to reduce the incidence of complex partial seizures and migraine headaches.
|
| DB00440,Trimethoprim exerts its antimicrobial effects by inhibiting an essential step in the synthesis of bacterial nucleic acids and proteins.
|
| DB00678,"Losartan is an angiotensin II receptor blocker used to treat hypertension, diabetic nephropathy,"
|
| DB00544,Fluorouracil is an antineoplastic anti-metabolite.
|
| DB00322,"Floxuridine is an anti-metabolite or a pyrimidine analog that works by disrupting the process S-phase of cell division, selectively targeting rapidly dividing cells."
|
| DB00379,"Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active."
|
| DB05219,Crisaborole has broad-spectrum anti-inflammatory activity by mainly targeting phosphodiesterase 4 (PDE4) enzyme that is a key regulator of inflammatory cytokine production
|
| DB00300,"This drug prevents viral DNA chain elongation through inhibition of enzymes necessary for host cell infection viral replication in HIV-1 and Hepatitis B infections ,"
|
| DB06268,Sitaxentan belongs to a class of drugs known as endothelin receptor antagonists (ERAs).
|
| DB11619,"Gestrinone is a synthetic steroidal hormone which has androgenic,"
|
| DB00530,Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer
|
| DB13167,Alclofenac is a non-steroidal anti-inflammatory drug.
|
| DB00751,Epinastine is an antihistamine and an inhibitor of histamine release from the mast cell for topical administration to the eyes
|
| DB00208,Ticlopidine is a prodrug that is metabolised to an as yet undetermined metabolite that acts as a platelet aggregation inhibitor.
|
| DB04575,Quinestrol is the 3-cyclopentyl ether of ethinyl estradiol (the active metabolite).
|
| DB01431,"Allylestrenol is a progestogen structurally related to progesterone that has been given in threatened and recurrent miscarriage, and to prevent premature labour."
|
| DB01601,Lopinavir inhibits the activity of an enzyme critical for the HIV viral lifecycle.
|
| DB01583,Thyroid hormone drugs are natural or synthetic preparations containing T<sub>4</sub> or T<sub>3</sub> or both
|
| DB00924,"Cyclobenzaprine is a skeletal muscle relaxant that works on areas of the brainstem to reduce skeletal muscle spasm, though its exact pharmacodynamic behaviour is currently unclear."
|
| DB00948,"Mezlocillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
|
| DB01251,Gliquidone is an anti-diabetic drug in the sulfonylurea class.
|
| DB00974,Edetate calcium is a heavy metal chelating agent
|
| DB09167,Dosulepin is a tricyclic antidepressant that interacts with various receptors and transporters
|
| DB00689,Cephaloglycin is an antibiotic related to cephalosporin but no longer in common use.
|
| DB00567,Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic.
|
| DB01289,Glisoxepide is a sulfonylurea agent.
|
| DB08860,Pitavastatin is an oral antilipemic agent which inhibits HMG-CoA reductase.
|
| DB01014,Balsalazide is a prodrug that has little or no pharmacologic activity until it is enzymatically cleaved in the colon to produce mesalamine (5-aminosalicylic acid)
|
| DB00274,Cefmetazole is a second-generation cephalosporin.
|
| DB00235,Milrinone is a bipyridine derivative with positive inotropic and lusitropic effects that also results in peripheral vasodilation with minimal chronotropic effects over a therapeutic range of 100 to 300 ng/mL
|
| DB06441,"Cangrelor is an intravenous, direct-acting,"
|
| DB01139,Cephapirin is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms
|
| DB00343,Diltiazem is an antihypertensive and vasodilating agent that works by relaxing the vascular muscle and reducing blood pressure.
|
| DB11079,Trolamine salicylate is a salicylate that inhibits cyclo-oxygenase (COX) enzymes responsible for generating pro-inflammatory factors such as to induce pain and inflammation
|
| DB01015,Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that inhibits a critical step in bacterial folate synthesis.
|
| DB01606,"Tazobactam inhibits the action of bacterial beta-lactamase producing organisms,"
|
| DB13873,"Various clinical studies have shown that elevated levels of total cholesterol, low-desnsity-lipoprotein (LDL-C),"
|
| DB00438,"Ceftazidime is a semisynthetic, broad-spectrum, third-generation cephalosporin antibiotic that is bactericidal through inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin-binding protein 3 (PBP3)."
|
| DB00267,Cefmenoxime is a semisynthetic beta-lactam cephalosporin antibiotic with activity similar to that of cefotaxime.
|
| DB00621,"Oxandrolone is an anabolic steroids indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections,"
|
| DB00641,Simvastatin is an oral antilipemic agent which inhibits HMG-CoA reductase.
|
| DB01330,Cefotetan is a semisynthetic cephamycin antibiotic that is administered intravenously or intramuscularly
|
| DB01602,Bacampicillin is a prodrug of ampicillin and is microbiologically inactive
|
| DB01053,"Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
|
| DB01241,Gemfibrozil alters lipid metabolism to treat patients with hyperlipidemia.
|
| DB00834,Mifepristone is a synthetic steroid with antiprogestational effects indicated for the medical termination of intrauterine pregnancy through 49 days' pregnancy
|
| DB00213,"This drug acts to decrease gastric acid secretion, which reduces stomach acidity."
|
| DB04855,Dronedarone is an antiarrhythmic agent that restores normal sinus rhythm and reduces heart rate in atrial fibrillation.
|
| DB00224,Indinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB00976,Telithromycin is a ketolide antibiotic which has an antimicrobial spectrum similar or slightly broader than that of penicillin
|
| DB06636,"Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA for the treatment of invasive aspergillosis and invasive mucormycosis,"
|
| DB00091,"Cyclosporine exerts potent immunosuppressive actions on T cells, thereby prolonging survival following organ and bone marrow transplants."
|
| DB00763,Methimazole inhibits the synthesis of thyroid hormones resulting in an alleviation of hyperthyroidism.
|
| DB00273,Topiramate prevents the occurrence of seizures and prevents migraine symptoms by reducing neural pathway excitability.
|
| DB01395,"Drospirenone inhibits the maturation of follicles and inhibits ovulation, preventing pregnancy."
|
| DB00389,Carbimazole is a carbethoxy derivative of methimazole.
|
| DB00281,"Excessive blood levels of lidocaine can cause changes in cardiac output, total peripheral resistance,"
|
| DB01321,Josamycin is a macrolide antibiotic from <i>Streptomyces narbonensis</i>.
|
| DB00252,Phenytoin is an anticonvulsant with a narrow therapeutic index.
|
| DB00686,Pentosan polysulfate sodium is a low molecular weight heparin-like compound.
|
| DB06736,"Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme,"
|
| DB06206,Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery
|
| DB06196,"Icatibant is a potent, specific, competitive, and selective peptidomimetic bradykinin beta2-receptor antagonist."
|
| DB08816,Ticagrelor is a P2Y<sub>12</sub> receptor antagonist that inhibits the formation of thromboses to reduce the risk of myocardial infarction and ischemic stroke
|
| DB00682,"Warfarin is an anticoagulant,"
|
| DB00006,Bivalirudin mediates an inhibitory action on thrombin by directly and specifically binding to both the catalytic site and anion-binding exosite of circulating and clot-bound thrombin
|
| DB00196,"Fluconazole has been demonstrated to show fungistatic activity against the majority of strains of the following microorganisms, curing fungal infections:_Candida albicans, Candida glabrata (Many strains are intermediately susceptible),"
|
| DB01026,"Ketoconazole, similarly to other azole antifungals,"
|
| DB00625,"Efavirenz (dideoxyinosine, ddI) is an oral non-nucleoside reverse transcriptase inhibitor (NNRTI)."
|
| DB09198,Lobeglitazone is an antidiabetic medication from the thiazolidinedione class of drugs.
|
| DB01101,Capecitabine is a fluoropyrimidine carbamate with antineoplastic activity indicated for the treatment of metastatic breast cancer and colon cancer
|
| DB01685,Topiroxostat reduces the synthesis of uric acid by competitively inhibiting xanthine oxidase in a selective and time-dependent manner
|
| DB09283,Trapidil exerts vasodilatory and antiplatelet effects .
|
| DB00788,"Naproxen is an established non-selective NSAID and is useful as an analgesic, anti-inflammatory and antipyretic."
|
| DB00412,"When rosiglitazone is used as monotherapy, it is associated with increases in total cholesterol, LDL, and HDL."
|
| DB03585,Oxyphenbutazone was withdrawn from the Canadian market in March 1985 due to concerns regarding bone marrow suppression
|
| DB00312,"Pentobarbital, a barbiturate,"
|
| DB01118,"After intravenous administration, amiodarone acts to relax smooth muscles that line vascular walls, decreases peripheral vascular resistance (afterload),"
|
| DB01024,Mycophenolic acid is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH) that blocks _de novo_ biosynthesis of purine nucleotides
|
| DB06209,Prasugrel is a thienopyridine ADP receptor inhibitors which inhibits platelet aggregation by irreversibly binding to P2Y12 receptors
|
| DB00661,"Verapamil is an L-type calcium channel blocker with antiarrhythmic, antianginal, and antihypertensive activity."
|
| DB00468,Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria.
|
| DB00398,No large changes in QTc interval were observed.
|
| DB01124,"Tolbutamide, a first-generation sulfonylurea antidiabetic agent,"
|
| DB05812,"Abiraterone is associated with decreases in PSA levels, tumor shrinkage (as evaluated by RECIST criteria),"
|
| DB09120,Zucapsaicin mediates an antinociceptive action via acting as an agonist at TRPV1.
|
| DB09063,Ceritinib is used for the treatment of adults with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) following failure (secondary to resistance or intolerance) of prior crizotinib therapy
|
| DB09073,"Due to its mechanism of action, palbociclib inhibits cell growth and suppresses DNA replication in retinoblastoma tumor suppressor gene (RB) proficient cancer cells."
|
| DB00277,"Theophylline, an xanthine derivative chemically similar to caffeine and theobromine,"
|
| DB06210,"Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines,"
|
| DB00599,"Thiopental, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical,"
|
| DB01437,"Glutethimide, like the barbiturates,"
|
| DB01112,Cefuroxime is a &beta
|
| DB00578,Carbenicillin is a semisynthetic penicillin.
|
| DB01060,"Amoxicillin competitively inhibit penicillin binding proteins,"
|
| DB01628,Etoricoxib is a COX-2 selective inhibitor (approximately 106 times more selective for COX-2 inhibition over COX-1)
|
| DB01393,Bezafibrate is an antilipemic agent that lowers cholesterol and triglycerides.
|
| DB00175,The action of pravastatin on the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase produces an increase in the expression of hepatic LDL receptors which in order decreases the plasma levels of LDL cholesterol
|
| DB00833,Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins.
|
| DB01017,Minocycline is a tetracycline antibiotic that binds to the bacterial 30S ribosomal subunit and interferes with protein synthesis.
|
| DB00316,Animal and clinical studies have determined that acetaminophen has both antipyretic and analgesic effects.
|
| DB01328,Cefonicid is a second-generation cephalosporin administered intravenously or intramuscularly.
|
| DB00636,Clofibrate is an antilipidemic agent similar to gemfibrozil.
|
| DB04574,Estropipate is an estrogenic substance.
|
| DB00779,Nalidixic acid is a quinolone antibacterial agent for oral administration.
|
| DB00493,Cefotaxime is a third generation intravenous cephalosporin antibiotic.
|
| DB01067,Glipizide is a blood glucose-lowering agent.
|
| DB01095,"Fluvastatin, the first synthetically-derived HMG-CoA reductase inhibitor, is a hydrophilic,"
|
| DB08918,"Levomilnacipran binds with high affinity to human serotonin (5-HT) and norepinephrine (NE) transporters ,"
|
| DB04896,When utilized to treat fibromyalgia
|
| DB01110,Miconazole is an azole antifungal that functions primarily through inhibition of a specific demethylase within the CYP450 complex
|
| DB00169,The in vivo synthesis of the predominant two biologically active metabolites of vitamin D occurs in two steps
|
| DB00207,"Macrolides stop bacterial growth by inhibiting protein synthesis and translation,"
|
| DB00993,"Azathioprine is an immunosuppressive agent which functions through modulation of rac1 to induce T cell apoptosis,"
|
| DB00364,This drug aids in the healing of duodenal ulcers
|
| DB00915,"Amantadine is an antiviral drug which also acts as an antiparkinson agent,"
|
| DB01435,Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops
|
| DB00335,Atenolol is a cardio-selective beta-blocker and as such exerts most of its effects on the heart.
|
| DB13179,"Troleandomycin, like other macrolide antibiotics,"
|
| DB00863,Ranitidine decreases the secretion of gastric acid stimulated by food and drugs.
|
| DB00320,DHE is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes
|
| DB00381,"**General pharmacodynamic effects**Amlodipine has a strong affinity for cell membranes,"
|
| DB00831,Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders
|
| DB01100,Pimozide is an orally active antipsychotic drug product which shares with other antipsychotics the ability to blockade dopaminergic receptors on neurons in the central nervous system.
|
| DB01221,"Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone,"
|
| DB00813,Fentanyl produces strong analgesia through its activation of opioid receptors.
|
| DB00950,"Fexofenadine relieves allergy symptoms by antagonizing the actions of histamine,"
|
| DB00537,Ciprofloxacin is a second generation fluoroquinolone that is active against many Gram negative and Gram positive bacteria.
|
| DB01054,"Nitrendipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
|
| DB00390,"Digoxin is a positive inotropic and negative chronotropic drug,"
|
| DB00966,Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT<sub>1</sub> receptor subtype
|
| DB01340,Cilazapril inhibits the production angiotensin II.
|
| DB00790,"Perindopril is a nonsulfhydryl prodrug that is metabolized via first pass effect (62%) and systemic hydrolysis (38%) to perindoprilat, its active metabolite,"
|
| DB01103,Quinacrine has been used as an antimalarial drug and as an antibiotic.
|
| DB00276,Amsacrine is an aminoacridine derivative that is a potent intercalating antineoplastic agent.
|
| DB00570,Vinblastine is a vinca alkaloid antineoplastic agent.
|
| DB00669,Sumatriptan constricts cranial blood vessels and prevents the release of vasoactive peptides.
|
| DB13874,"In a study involving adult patients with relapsed or refractory AML, overall response rate of 40."
|
| DB09102,Daclatasvir is a direct-acting antiviral agent that targets the NS5A and causes a decrease in serum HCV RNA levels
|
| DB00936,"Salicylic acid treats acne by causing skin cells to slough off more readily,"
|
| DB01088,Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds.
|
| DB00770,Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation.
|
| DB00608,"Chloroquine inhibits the action of heme polymerase,"
|
| DB00655,"Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine,"
|
| DB00203,In vitro studies have shown that sildenafil is selective for phosphodiesterase-5 (PDE5) .
|
| DB00810,Biperiden is a weak peripheral anticholinergic agent.
|
| DB01037,Dopamine is an essential chemical that occurs in many parts of the body.
|
| DB01370,"A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26."
|
| DB01162,Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocker
|
| DB06154,"Organic nitrate which causes systemic vasodilation, decreasing cardiovascular preload ."
|
| DB00624,Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics
|
| DB01234,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
|
| DB00694,Daunorubicin is an anthracycline antibiotic and antineoplastic agent
|
| DB00264,Administration of metoprolol in normal subjects is widely reported to produce a dose-dependent reduction on heart rate and cardiac output.
|
| DB00367,"Levonorgestrel prevents pregnancy by interfering with ovulation, fertilization,"
|
| DB06414,Clinical trials have shown no prolongation of QT intervals on electrocardiograms after 8 days of dosing
|
| DB05351,Dexlansoprazole is a proton pump inhibitor (PPI) and is included in the drug class of antisecretory compounds
|
| DB04868,"Nilotinib is a transduction inhibitor that targets BCR-ABL, c-kit and PDGF, for the potential treatment of various leukemias,"
|
| DB00477,Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia.
|
| DB00503,Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB00520,"Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins."
|
| DB00690,"Flurazepam, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM)."
|
| DB00358,Sporozoites located in the salivary glands of mosquitoes infected with malaria parasites are introduced into the bloodstream of a human host during mosquito feeding.
|
| DB01032,"Probenecid is a uricosuric and renal tubular blocking agent and is used in combination with colchicine to treat chronic gouty arthritis when complicated by frequent,"
|
| DB00201,"Caffeine stimulates the central nervous system (CNS), heightening alertness, and sometimes causing restlessness and agitation."
|
| DB00701,Amprenavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB08827,Lomitapide directly inhibits microsomal triglyceride transfer protein (MTP)
|
| DB00345,"Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid."
|
| DB00637,Astemizole is a second generation H<sub>1</sub>-receptor antagonist.
|
| DB00351,Megestrol is a synthetic progestin and has the same physiologic effects as natural progesterone.
|
| DB11363,Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase
|
| DB13879,"In a biochemical assay studying clinical isolates of HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a, glecaprevir displayed IC50 values ranging from 3."
|
| DB12026,Voxilaprevir is a direct-acting antiviral agent that targets viral NS3/4A protein and causes a decrease in serum HCV RNA levels
|
| DB00418,"Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical,"
|
| DB00474,"Methohexital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical,"
|
| DB00671,"Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime."
|
| DB01207,"Ridogrel, a combined thromboxane synthase inhibitor and receptor antagonist,"
|
| DB01175,Escitalopram belongs to a class of medications called selective serotonin re-uptake inhibitors (SSRIs)
|
| DB00726,Trimipramine is a tricyclic antidepressant.
|
| DB00437,Allopurinol decreases the production of uric acid by stopping the biochemical reactions that precede its formation .
|
| DB00487,Pefloxacin is a fluoroquinolone antibiotic.
|
| DB00176,"Fluvoxamine, an aralkylketone-derivative agent ,"
|
| DB00193,Tramadol modulates the descending pain p
|
| DB00957,Norgestimate is a progestin that suppresses ovulation for contraception and reduces free testosterone to treat moderate acne vulgaris.
|
| DB09265,Lixisenatide acts as an agonist at the GLP-1 receptor.
|
| DB09256,Tegafur is an antineoplastic agent that belongs in the class of pyrimidine analogues.
|
| DB06724,"Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid,"
|
| DB08938,"Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux."
|
| DB00500,Tolmetin is a nonsteroidal anti-inflammatory agent.
|
| DB01384,Paramethasone is a glucocorticoid with the general properties of corticosteroids
|
| DB01047,Fluocinonide is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
|
| DB00687,Fludrocortisone is a synthetic mineralocorticoid used to replace endogenous in conditions resulting in missing or inadequate endogenous synthesis
|
| DB01708,DHEA is naturally produced from cholesterol through two cytochrome P450 enzymes.
|
| DB00741,"Hydrocortisone binds to the glucocorticoid receptor leading to downstream effects such as inhibition of phospholipase A2, NF-kappa B, other inflammatory transcription factors,"
|
| DB00180,Flunisolide is a synthetic corticosteroid.
|
| DB08881,"BRAF activation results in cell growth, proliferation, and metastasis."
|
| DB00658,Patients with end-stage renal disease (ESRD) retain phosphorus and can develop hyperphosphatemia.
|
| DB09147,"Iron supplementation typically results in increases in serum iron, transferrin-bound iron,"
|
| DB09275,Bismuth subcitrate is very effective in the treatment of gastroduodenal disorders and appears to act via several mechanisms.
|
| DB03754,An organic amine proton acceptor.
|
| DB09281,Magnesium trisilicate works by increasing the pH of gastric juice via a neutralisation reaction.
|
| DB00896,Rimexolone is a glucocorticoid corticosteroid for systemic use.
|
| DB00443,"Corticosteroids bind to the glucocorticoid receptor inhibiting pro-inflammatory signals,"
|
| DB00860,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
|
| DB00394,"Inflammatory conditions, including asthma, dermatoses, and allergic rhinitis,"
|
| DB00764,"Mometasone is a medium-potency synthetic corticosteroid with antiinflammatory, antipruritic,"
|
| DB02187,"Equilin is a component of Premarin (conjugated estrogens), a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 alpha-dihydroequilin,"
|
| DB06792,In vitro studies have shown that lanthanum binds phosphate in the physiologically relevant pH range of 3 to 7.
|
| DB09267,"In general,"
|
| DB01591,Solifenacin antagonizes the M2 and M3 muscarinic receptors in the bladder to treat an overactive bladder.
|
| DB13595,"Various non-prescription antacid products are available to the general public to purchase and use as a treatment for relieving the occasional,"
|
| DB00346,"By selectively inhibiting alpha adrenergic receptors in the lower urinary tract, alfuzosin causes smooth muscle relaxation in the bladder neck and prostate, improving urine flow, thereby reducing BPH symptoms."
|
| DB02546,"Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL),"
|
| DB00223,"Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties."
|
| DB09091,Tixocortol presents the characteristic of local action which reduces significantly the side effects of systemic glucocorticoids.
|
| DB01151,"Desipramine, a secondary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene."
|
| DB00324,Corticosteroids such as fluorometholone inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing.
|
| DB00663,"Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties."
|
| DB01410,"Ciclesonide is a pro-drug that is enzymatically hydrolyzed to a pharmacologically active metabolite,"
|
| DB00620,Triamcinolone is a corticosteroid with anti-inflammatory properties.
|
| DB00288,Amcinonide is a topical corticosteroid.
|
| DB08971,Fluocortolone is a glucocorticoid with anti-inflammatory activity used topically for various skin disorders
|
| DB08970,Fluprednidene is a corticosteroid.
|
| DB00104,Octreotide mimics the naturally occurring hormone known as somatostatin.
|
| DB00333,"Overall, methadone's pharmacological actions result in analgesia, suppression of opioid withdrawal symptoms, sedation, miosis (through binding to receptors in the pupillary muscles), sweating, hypotension,"
|
| DB08893,"Mirabegron exerts its pharmacologic effects by forcing bladder smooth muscle to relax,"
|
| DB00734,"The primary action of risperidone is to decrease dopaminergic and serotonergic pathway activity in the brain,"
|
| DB01189,Desflurane is a general inhalation anesthetic.
|
| DB01238,"Aripiprazole has high affinity for serotonin type 2 (5HT2), dopamine type 2 (D2), alpha1 and 2 adrenergic,"
|
| DB00674,Galantamine is a competitive and reversible inhibitor of acetylcholinesterase that works to increase acetylcholine levels.
|
| DB09080,"Olodaterol is a potent agonist of the human beta2-adrenergic receptor in vitro,"
|
| DB00710,Ibandronate is a nitrogen containing bisphosphonate used to treat and prevent osteoporosis in postmenopausal women.
|
| DB13783,The effect of acemetacin causes a weak reduction of prostaglandin synthesis which generates an anti-inflammatory and analgesic effect
|
| DB01248,Docetaxel is a taxoid antineoplastic agent.
|
| DB06772,Cabaitaxel has anti-tumour properties and is effective against docetaxel-sensitive and -insensitive tumours
|
| DB11093,Increases plasma calcium levels leading
|
| DB00258,Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia
|
| DB09146,Significant increases in serum iron and serum ferritin and significant decreases in total iron binding capacity occurred four weeks from the initiation of iron sucrose treatment
|
| DB00588,"Systemically, fluticasone propionate activates glucocorticoid receptors, and inhibits lung eosinophilia in rats."
|
| DB13158,"Topical corticosteroid like clobetasone are synthetic derivatives of cortisone which produce anti-inflammatory, antiproliferative,"
|
| DB01260,Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use.
|
| DB00838,"Like other topical corticosteroids, clocortolone has anti-inflammatory, antipruritic, and vasoconstrictive properties."
|
| DB00531,Cyclophosphamide is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
|
| DB11126,Calcium Gluconate is the gluconate salt of calcium.
|
| DB11348,Calcium phosphate reacts with acid in the stomach to raise the pH
|
| DB01396,Digitoxin is a cardiac glycoside sometimes used in place of DIGOXIN.
|
| DB01592,The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia.
|
| DB06723,"Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid,"
|
| DB01390,"Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration,"
|
| DB01164,Calcium is the fifth most abundant element in the body and the major fraction is in the bony structure.
|
| DB09104,"As an antacid,"
|
| DB01377,Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase.
|
| DB00846,"Flurandrenolide is primarily effective because of its anti-inflammatory, antipruritic,"
|
| DB11921,"Deflazacort exerts anti-inflammatory activity in DMD, likely improving various symptoms,"
|
| DB13231,"Both components of calcium lactate, calcium ion and lactic acid, play essential roles in the human body as a skeletal element an energy source,"
|
| DB06781,Difluprednate is a corticosteroid used as an anti-inflammatory steroidal drug used primarily in ocular surgery
|
| DB08905,"By significantly reducing estrogen levels in the bloodstream, formestane may exhibit antitumor activity."
|
| DB01130,Corticosteroids diffuse across cell membranes and complex with specific cytoplasmic receptors.
|
| DB01229,"Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary,"
|
| DB13142,Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets
|
| DB00547,"Like other topical corticosteroids, desoximetasone has anti-inflammatory, antipruritic, and vasoconstrictive properties."
|
| DB09095,"Diflucortolone is a steroid with the properties of being an anti-inflammatory,"
|
| DB01078,"Deslanoside is a cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms,"
|
| DB01069,"Promethazine is is a histamine H1 antagonist that can be used for it's ability to induce sedation, reduce pain,"
|
| DB06663,Signifor® is an analogue of somatostatin that promotes reduced levels of cortisol secretion in Cushing's disease patients
|
| DB01268,"Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA on January 26,"
|
| DB00862,Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH)
|
| DB00199,"Macrolides, such as erythromycin, stop bacterial growth by inhibiting protein synthesis and translation, treating bacterial infections."
|
| DB00363,Clozapine is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives and is indicated for the treatment of schizophrenia
|
| DB01075,"Diphenhydramine has anti-histaminic (H1-receptor), anti-emetic,"
|
| DB00450,Droperidol produces marked tranquilization and sedation.
|
| DB00653,"Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic,"
|
| DB00934,Maprotiline is a tetracyclic antidepressant.
|
| DB00753,Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
|
| DB06825,"The first administration of triptorelin is followed by a transient surge of follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol,and testosterone."
|
| DB08871,Linear
|
| DB00808,"Classified as a sulfonamide diuretic, indapamide is an effective antihypertensive agent and by extension,"
|
| DB00014,The pharmacokinetics of goserelin have been determined in both male and female healthy volunteers and patients.
|
| DB08868,"In multiple sclerosis, fingolimod binds to sphingosine receptors, reducing its associated neuroinflammation."
|
| DB00596,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
|
| DB01380,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
|
| DB00959,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals,"
|
| DB09241,Methylene blue is an oxidation-reduction agent.
|
| DB01045,Rifampin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells.
|
| DB06786,"Halcinonide is a corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses,"
|
| DB06237,Avanafil is a strong competitive inhibitor of phosphodiesterase 5 (PDE5) with a demonstrated _in vitro_ IC<sub>50</sub> of 5.
|
| DB00611,Butorphanol is a synthetic opioid agonist-antagonist analgesic with a pharmacological and therapeutic profile that has been well established since its launch as a parenteral formulation in 1978
|
| DB01209,Dezocine is a parenteral narcotic analgesic possessing both agonist and antagonist activity.
|
| DB01452,The onset of heroin's effects is dependent on the method of administration.
|
| DB00295,"Morphine binding to opioid receptors blocks transmission of nociceptive signals, signals pain-modulating neurons in the spinal cord,"
|
| DB00802,Alfentanil is a synthetic opioid analgesic.
|
| DB01551,"Possible opioid related side effects include, but are not limited to, drowsiness, nausea, headache, dry mouth, constipation, difficulty passing urine,"
|
| DB00318,**General effects**Codeine is a weak narcotic pain reliever and cough suppressant that is similar to morphine and hydrocodone
|
| DB01002,"Levobupivacaine, a local anesthetic agent, is indicated for the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures,"
|
| DB11609,Normethadone is an opioid which suppresses coughing by central and peripheral mechanisms
|
| DB01200,Bromocriptine stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects.
|
| DB09082,Vilanterol is a selective long-acting beta2-adrenergic agonist (LABA) with inherent 24-hour activity for once daily treatment of COPD and asthma
|
| DB01169,"Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from,"
|
| DB01001,"Salbutamol (INN) or albuterol (USAN), a moderately selective beta(2)-receptor agonist similar in structure to terbutaline,"
|
| DB00449,Dipivefrin is a member of a class of drugs known as prodrugs
|
| DB09242,"Antihypertensive agent whose site of action is the Central Nervous System (CNS),"
|
| DB00413,"**Parkinson's Disease**Through the stimulation of dopamine receptors,"
|
| DB00435,"Persistent pulmonary hypertension of the newborn (PPHN) occurs as a primary developmental defect or as a condition secondary to other diseases such as meconium aspiration syndrome (MAS), pneumonia,"
|
| DB00178,"Ramipril is an ACE inhibitor similar to benazepril, fosinopril and quinapril."
|
| DB01392,Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine.
|
| DB00212,Remikiren is an orally available renin inhibitor with an established blood pressure-lowering effect in patients with essential hypertension.
|
| DB01407,Clenbuterol is a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses.
|
| DB04840,Debrisoquin is an adrenergic neuron-blocking drug similar in effects to guanethidine.
|
| DB01291,Pirbuterol is a beta-2 adrenergic bronchodilator.
|
| DB01102,"Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses,"
|
| DB00657,"Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker,"
|
| DB00849,"Methylphenobarbital, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines,"
|
| DB00598,Labetalol antagonizes various adrenergic receptors to decrease blood pressure.
|
| DB00571,Propranolol is a beta-adrenergic receptor antagonist used to treat hypertension.
|
| DB04846,Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.
|
| DB00612,"Bisoprolol decreases heart rate (chronotropy), decreases contractility (inotropy),"
|
| DB00373,"Timolol, when administered by the ophthalmic route, rapidly reduces intraocular pressure."
|
| DB00681,Amphotericin B shows a high order of <i>in vitro</i> activity against many species of fungi.
|
| DB01041,"Thalidomide, originally developed as a sedative, is an immunomodulatory and anti-inflammatory agent with a spectrum of activity that is not fully characterized."
|
| DB01466,Ethylmorphine is metabolized by the enzyme cytochrome P450 2D6 to morphine
|
| DB09286,"Pipamperone is an antipsychotic medication that has sedative effects, which may be beneficial in the management of agitation and disordered sleep ."
|
| DB00652,Pentazocine is a potent analgesic which when administered orally in a 50 mg dose appears equivalent in analgesic effect to 60 mg (1 grain) of codeine
|
| DB01192,Oxymorphone is a semi-synthetic opioid substitute for morphine.
|
| DB00818,Propofol is a sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation.
|
| DB00633,"Dexmedetomidine activates 2-adrenoceptors,"
|
| DB01274,"Arformoterol, the active (R,R)-enantiomer of formoterol, is a selective long-acting β2-adrenergic receptor agonist (beta2-agonist) that has two-fold greater potency than racemic formoterol (which contains both the (S,S) and (R,"
|
| DB05039,Bronchodilator drugs are the foundation for the treatment of chronic obstructive pulmonary disease.
|
| DB09227,Barnidipine reduces peripheral resistance and lowers blood pressure.
|
| DB01244,Bepridil is a calcium channel blocker that has well characterized anti-anginal properties and known but poorly characterized type 1 anti-arrhythmic and anti-hypertensive properties
|
| DB09232,Administration of cilnidipine has been shown to present an antisympathetic profile in vitro and in vivo.
|
| DB00401,"Nisoldipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
|
| DB00668,Epinephrine is a sympathomimetic drug
|
| DB00727,"Nitroglycerin causes the relaxation of vascular smooth muscles, causing arteriolar and venous dilatation."
|
| DB00594,"Amiloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents."
|
| DB00177,Valsartan inhibits the pressor effects o
|
| DB00519,"Trandolapril is the ethyl ester prodrug of a nonsulfhydryl ACE inhibitor, trandolaprilat."
|
| DB00692,Phentolamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma.
|
| DB00703,Methazolamide is topical carbonic anhydrase inhibitor.
|
| DB00542,"Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Benazeprilat,"
|
| DB00816,"Orciprenaline (also known as metaproterenol), a synthetic amine, is structurally and pharmacologically similar to isoproterenol."
|
| DB00752,Tranylcypromine belongs to a class of antidepressants called monoamine oxidase inhibitors (MAOIs).
|
| DB01355,Hexobarbital is a barbiturate derivative having hypnotic and sedative effects.
|
| DB00421,Originally spironolactone was only studied for its potassium sparing diuretic effect.
|
| DB00708,"**Effect on the Central Nervous System (CNS)** In clinical settings, sufentanil exerts its principal pharmacologic effects on the central nervous system."
|
| DB06738,Ketobemidone is a powerful opioid analgesic.
|
| DB00899,Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action.
|
| DB00575,"Clonidine functions through agonism of alpha-2 adrenoceptors which have effects such as lowering blood pressure, sedation,"
|
| DB01433,Methadyl Acetate is a narcotic analgesic with a long onset and duration of action
|
| DB00844,Nalbuphine is a synthetic opioid agonist-antagonist analgesic of the phenanthrene series.
|
| DB00454,Meperidine is a synthetic opiate agonist belonging to the phenylpiperidine class.
|
| DB00647,"Propoxyphene, a synthetic opiate agonist, is structurally similar to methadone."
|
| DB00714,Apomorphine is a dopaminergic agonist that may stimulate regions of the brain involved in motor control
|
| DB00310,Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment
|
| DB09292,"n a 7-day valsartan-controlled study in patients with reduced ejection fraction (HFrEF), administration of sacubitril + valsartan (Entresto) resulted in a significant non-sustained increase in natriuresis,"
|
| DB01282,"Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth."
|
| DB00325,Nitroprusside a powerful vasodilator relaxes the vascular smooth muscle and produce consequent dilatation of peripheral arteries and veins.
|
| DB00631,Clofarabine is a purine nucleoside antimetabolite that differs from other puring nucleoside analogs by the presence of a chlorine in the purine ring and a flourine in the ribose moiety
|
| DB00922,Levosimendan is a new Ca-sensitizing inotropic agent.
|
| DB09279,Fimasartan is a selective angiotensin receptor 1 (AR1) inhibitor
|
| DB00800,"Fenoldopam is an agonist at D<sub>1</sub>-like dopamine receptors, binds to α<sub>2</sub>-adrenoceptors,"
|
| DB00956,Hydrocodone inhibits pain signaling in both the spinal cord and brain .
|
| DB09214,This drug is an isomer of ketoprofen.
|
| DB00397,"Phenylpropanolamine (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion."
|
| DB00841,"Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic,"
|
| DB01247,"In vivo and in vitro studies demonstrated isocarboxazid-driven inhibition of MAO in the brain, heart, and liver."
|
| DB00695,"Furosemide manages hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease,"
|
| DB01408,Bambuterol is a long acting beta2-adrenoceptor agonist used in the treatment of asthma.
|
| DB08907,This drug increases urinary glucose excretion and decreases the renal threshold for glucose (RTG) in a dose-dependent manner
|
| DB00187,"Esmolol, commonly marketed under the trade name Brevibloc,"
|
| DB00521,"Carteolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity."
|
| DB00497,Oxycodone acts directly on a number of tissues not related to its analgesic effect.
|
| DB00232,"Methyclothiazide, a diuretic-antihypertensive agent, is a member of the benzothiadiazine (thiazide) class of drugs."
|
| DB09236,acidipine is a specific and potent calcium antagonist with a predominant selectivity for calcium channels in the vascular smooth muscle
|
| DB00755,"Tretinoin, also known as all-<i>trans</i>-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol)."
|
| DB00883,Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris
|
| DB13139,It acts by relaxing smooth muscle in the bronchial tubes to increase air flow and relieve acute shortness of breath
|
| DB09220,"Nicorandil is a potassium channel opener with nitrovasodilator (NO donor) actions,"
|
| DB00780,The elimination of monoamine oxidase by phenelzine results in the elevation of brain amines such as 2-phenylethylamine which is a metabolite of phenelzine
|
| DB00921,Buprenorphine interacts predominately with the opioid mu-receptor.
|
| DB06712,"Nilvadipine is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine."
|
| DB06204,Tapentadol is a centrally-acting synthetic analgesic that is 18 times less potent than morphine in binding mu-opioid receptors
|
| DB00486,Nabilone is a cannabinoid with therapeutic uses.
|
| DB01227,Levomethadyl acetate (also known as LAAM) is a synthetic synthetic opioid analgesic with multiple actions quantitatively similar to those as morphine
|
| DB00679,Thioridazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders
|
| DB00323,"Tolcapone is a potent, selective, and reversible inhibitor of catechol-O-methyltransferase (COMT)."
|
| DB00774,Hydroflumethiazide is an oral thiazide used to treat hypertension and edema.
|
| DB01143,Amifostine is an organic thiophosphate c
|
| DB06212,Urine volume and fluid intake increase in a dose dependent manner which results in overall negative fluid balance in patients taking tolvaptan
|
| DB01199,Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid
|
| DB00483,Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation
|
| DB00476,"Duloxetine, through increasing serotonin and norepinephrine concentrations in Onuf's nucleus,"
|
| DB00933,"Mesoridazine, the besylate salt of a metabolite of thioridazine,"
|
| DB00292,Etomidate is a non-barbiturate hypnotic that acts at the level of the reticular-activating system to produce anesthesia.
|
| DB01122,"Ambenonium, similar to pyridostigmine and neostigmine,"
|
| DB00981,"Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission."
|
| DB01233,Metoclopramide increases gastric emptying by decreasing lower esophageal sphincter (LES) pressure.
|
| DB01115,Nifedipine is an inhibitor of L-type voltage gated calcium channels that reduces blood pressure and increases oxygen supply to the heart
|
| DB06711,"Naphazoline is a sympathomimetic alpha adrenergic agonist that acts to vasoconstrict nasal or ocular arterioles,"
|
| DB01611,Hydroxychloroquine affects the function of lysozomes in humans as well as plasmodia
|
| DB00680,Moricizine is used to treat irregular heartbeats (arrhythmias) and to maintain a normal heart rate.
|
| DB01116,Trimethaphan is indicated for production
|
| DB01154,"Thiamylal, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines,"
|
| DB00820,"Tadalafil exerts a therapeutic effect in ED by increasing sexual stimulation-dependant smooth muscle relaxation in the penis,"
|
| DB00484,Brimonidine is a highly selective alpha-2 adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenergic receptor than the alpha1-adrenergic receptor.
|
| DB09291,"Rolapitant is a potent, highly selective,"
|
| DB06697,"In the body, artemether is metabolized into the active metabolite metabolite dihydroartemisinin."
|
| DB00349,"Similar to other benzodiazepines, clobazam binds to the interface of the α and γ2-subunit of the GABA-A receptor."
|
| DB00508,"Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists."
|
| DB00206,Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage
|
| DB01615,Aceprometazine is a drug with neuroleptic and anti-histamine properties.
|
| DB01614,Acepromazine is one of the phenothiazine derivative psychotropic drugs.
|
| DB01245,Decamethonium acts as a depolarizing muscle relaxant or neuromuscular blocking agent.
|
| DB00772,Malathion is an organophosphate insecticide commonly used to control mosquitos and other flying insects.
|
| DB00545,"Pyridostigmine bromide, designated as 3-hydroxy-1-methyl-pyridinium bromide dimethyl-carbamate,"
|
| DB00677,Isoflurophate is used as ocular drops in the treatment of chronic glaucoma.
|
| DB00696,Ergotamine is a vasoconstrictor and alpha adrenoreceptor antagonist.
|
| DB00524,"Metolazone is a quinazoline diuretic,"
|
| DB06694,Xylometazoline is a sympathomimetic agent that causes vasoconstriction of the nasal mucosa.
|
| DB00217,Bethanidine is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission.
|
| DB01577,"Methamphetamine is a potent central nervous system stimulant which affects neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite,"
|
| DB00796,"Candesartan cilexetil is an ARB prodrug that is rapidly converted to candesartan, its active metabolite,"
|
| DB00275,"Overall, olmesartan's physiologic effects lead to reduced blood pressure, lower aldosterone levels, reduced cardiac activity,"
|
| DB00613,"Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity,"
|
| DB01119,Diazoxide is a potassium channel activator.
|
| DB01168,Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
|
| DB00805,"Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain."
|
| DB00182,From its mechanism of action
|
| DB09244,"Pirlindole regulates that metabolism of norepinephrine and catecholamines, leading to relief of depressive symptoms."
|
| DB00614,Furoxone has a broad antibacterial spectrum covering the majority of gastrointestinal tract pathogens including E.
|
| DB09280,"Results from clinical trials indicated that treatment with Orkambi (lumacaftor/ ) results in improved lung function, reduced chance of experiencing a pulmonary exacerbation, reduced sweat chloride,"
|
| DB00705,Delavirdine is a non-nucleoside reverse transcriptase inhibitor (nNRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1)
|
| DB00227,Lovastatin is an oral antilipemic agent which reversibly inhibits HMG-CoA reductase.
|
| DB00501,Cimetidine is a histamine H<sub>2</sub>-receptor antagonist.
|
| DB00280,"Disopyramide is an anti-arrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that are life-threatening."
|
| DB09204,Preclinical studies showed a lack of intrinsic sympathomimetic activities or membrane-establishing properties.
|
| DB01319,Fosamprenavir is hydrolyzed by cellular phosphatases to the antiretroviral protease inhibitor amprenavir.
|
| DB00951,"Isoniazid is a bactericidal agent active against organisms of the genus Mycobacterium, specifically <i>M."
|
| DB09039,Eliglustat is a specific inhibitor of glucosylceramide synthase (IC<sub>50</sub> =10 ng/mL).
|
| DB00420,Promazine belongs to a group of medications known as the phenothiazine antipsychotics.
|
| DB00850,"Perphenazine is a piperazinyl phenothiazine, acts on the central nervous system,"
|
| DB01018,Guanfacine is a selective alpha-2A adrenergic receptor agonist but it is unclear how this translates to the treatment of ADHD
|
| DB00944,Demecarium is a long-acting cholinesterase inhibitor and potent miotic.
|
| DB00436,"Bendroflumethiazide, a thiazide diuretic,"
|
| DB00393,Nimodipine belongs to the class of pharmacological agents known as calcium channel blockers
|
| DB00528,"Lercanidipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris,"
|
| DB06707,Levonordefrin is a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions.
|
| DB00629,"Guanabenz, a centrally acting α-2 adrenergic agonist,"
|
| DB09112,Sodium nitrite reverses cyanide toxicity and produces blood vessel dilation
|
| DB08896,Regorafenib is an orally-administered inhibitor of multiple kinases.
|
| DB00226,High blood pressure adds to the work load of the heart and arteries.
|
| DB01580,Oxprenolol is a non-selective beta blocker with some intrinsic sympathomimetic activity.
|
| DB00433,Prochlorperazine is an antipsychotic agent that works to promote postsynaptic inhibition of dopaminergic neurons.
|
| DB01267,Paliperidone is an atypical antipsychotic developed by Janssen Pharmaceutica.
|
| DB09235,"Dihydropyridines (DHPs), act mainly on L-type calcium channels, essentially causing reflex tachycardia,"
|
| DB01158,Bretylium is a bromobenzyl quaternary ammonium compound which selectively accumulates in sympathetic ganglia and their postganglionic adrenergic neurons where it inhibits norepinephrine release by depressing adrenergic nerve terminal excitability
|
| DB09477,"Enalaprilat injection results in the reduction of both supine and standing systolic and diastolic blood pressure, usually with no orthostatic component."
|
| DB01622,Thioproperazine is a potent neuroleptic with antipsychotic properties.
|
| DB00195,"Betaxolol is a competitive, beta(1)-selective (cardioselective) adrenergic antagonist."
|
| DB00872,"Conivaptan is a nonpeptide,"
|
| DB00214,It is widely known that administration of torasemide can attenuate renal injury and reduce the severity of acute renal failure.
|
| DB01203,Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure
|
| DB01224,"Quetiapine improves the positive and negative symptoms of schizophrenia and major depression by acting on various neurotransmitter receptors, such as the serotonin and dopamine receptors."
|
| DB01010,Edrophonium is a short and rapid-acting anticholinesterase drug.
|
| DB01324,"As a thiazide diuretic, Polythiazide inhibits the sodium-chloride symporter which decreases solute reabsorption leading to a retention of water in the urine,"
|
| DB01186,Pergolide stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects.
|
| DB00852,Pseudoephedrine causes vasoconstriction which leads to a decongestant effect.
|
| DB01246,"Trimeprazine (also known as Alimemazine) is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics,"
|
| DB00321,**Effects in pain and depression**Amitriptyline is a tricyclic antidepressant and an analgesic.
|
| DB00446,Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically.
|
| DB06708,Lumefantrine is a blood schizonticide active against erythrocytic stages of <i>Plasmodium falciparum</i>.
|
| DB06413,"Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA),"
|
| DB01129,Rabeprazole prevents the production of acid in the stomach.
|
| DB06729,Sulfaphenazole is a sulfonamide antibacterial
|
| DB00557,Hydroxyzine blocks the activity of histamine to relieve allergic symptoms such as pruritus
|
| DB01114,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
|
| DB00904,"Ondansetron is a highly specific and selective serotonin 5-HT<sub>3</sub> receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors ,"
|
| DB00748,Carbinoxamine is a first generation antihistamine of the ethanolamine class.
|
| DB01057,"Echothiophate Iodide is a potent,"
|
| DB01087,Primaquine is an antimalarial agent and is the essential co-drug with chloroquine in treating all cases of malaria.
|
| DB06262,Droxidopa is an orally active synthetic precursor of norepinephrine that increases the deficient supply of norepinephrine in patients with NOH
|
| DB05271,Rotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity
|
| DB06287,Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC).
|
| DB06684,Vilazodone increases serotonin levels in the brain by inhibiting the reuptake of serotonin while acting as a partial agonist on serotonin-1A receptors
|
| DB00822,Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol
|
| DB00514,Dextromethorphan is an opioid-like molecule indicated in combination with other medication in the treatment of coughs and pseudobulbar affect.
|
| DB00259,Sulfanilamide is a sulfonamide antibiotic.
|
| DB02701,An important compound functioning as a component of the coenzyme NAD.
|
| DB04839,Cyproterone is an antiandrogen.
|
| DB01096,"Oxamniquine is an anthelmintic with schistosomicidal activity against <i>Schistosoma mansoni</i>,"
|
| DB01058,Praziquantel is an anthelmintic used in most schistosome and many cestode infestations.
|
| DB00843,"By inhibiting the acetylcholinesterase enzyme, donepezil improves the cognitive and behavioral signs and symptoms of Alzheimer's Disease, which may include apathy, aggression, confusion,"
|
| DB01400,Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine.
|
| DB00865,"Benzphetamine, a phenylalkylamin,"
|
| DB00496,Darifenacin is a competitive muscarinic receptor antagonist
|
| DB01626,Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties.
|
| DB01156,"Bupropion is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitors, or other known antidepressant agents."
|
| DB01043,**General effects**This drug inhibits calcium influx into cells that is normally caused by chronic NMDA receptor activation by glutamate .
|
| DB00857,Terbinafine is an allylamine antifungal that inhibits squalene epoxidase (also known as squalene monooxygenase) to prevent the formation of ergosterol and cause an accumulation of squalene
|
| DB00907,"Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral,"
|
| DB01182,"Propafenone is a Class 1C antiarrhythmic drug with local anesthetic effects, and a direct stabilizing action on myocardial membranes."
|
| DB01021,"Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis,"
|
| DB00797,Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN)
|
| DB01608,Pericyazine is a phenothiazine of the piperidine group.
|
| DB00606,"Like other thiazides, cyclothiazide promotes water loss from the body (diuretics)."
|
| DB04948,"In clinical trials, lofexidine presented more severe opioid withdrawal effects than observed with methadone."
|
| DB00935,Oxymetazoline is an adrenergic α<sub>1</sub>- and α<sub>2</sub>-agonist and a direct-acting sympathomimetic drug.
|
| DB06267,Udenafil is a potent selective phosphodiesterase type 5 (PDE5) inhibitor
|
| DB00296,"In contrast to most other local anesthetics, the presence of does not affect the time of onset, duration of action,"
|
| DB08877,"Ruxolitinib is an antineoplastic agent that inhibits cell proliferation,"
|
| DB00457,"**Effects on blood pressure**The pharmacodynamic and therapeutic effect of this drug includes is a decrease in blood pressure as well as clinically significant decreases in cardiac output,"
|
| DB00489,Sotalol is a competitive inhibitor of the rapid potassium channel.
|
| DB11730,"Ribociclib is a selective cyclin-dependent kinase inhibitor,"
|
| DB09048,Netupitant is an antiemitic drug approve
|
| DB04871,Lorcaserin produced a dose-dependent weight loss over a 12-week period by promoting satiety and decreasing food consumption
|
| DB00502,"Use of the first-generation antipsychotics (including haloperidol) is considered highly effective for the management of the ""positive"" symptoms of schizophrenia including hallucinations, hearing voices, aggression/hostility, disorganized speech,"
|
| DB06603,"Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma."
|
| DB00623,Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders
|
| DB00880,"Like other thiazides, chlorothiazide promotes water loss from the body (diuretics)."
|
| DB00742,"Chemically, mannitol is an alcohol and a sugar, or a polyol; it is similar to xylitol or sorbitol."
|
| DB08895,Tofacitinib targets inflammation present in rheumatoid arthritis by inhibiting the janus kinases involved in the inflammatory response pathway
|
| DB00869,Dorzolamide is a carbonic anhydrase inhibitor that reduces elevated intraocular pressure in open-angle glaucoma or ocular hypertension.
|
| DB00287,"Travoprost, an isopropyl ester prodrug,"
|
| DB01367,Rasagiline is a propargylamine and an irreversible inhibitor of monoamine oxidase (MAO).
|
| DB00999,"Hydrochlorothiazide prevents the reabsorption of sodium and water from the distal convoluted tubule,"
|
| DB00881,Quinapril is a prodrug of an angiotensin converting enzyme (ACE) inhibitor used in the treatment of hypertension or adjunct in the treatment of heart failure
|
| DB01193,"Acebutolol is a cardioselective, beta-adrenoreceptor blocking agent, which possesses mild intrinsic sympathomimetic activity (ISA) in its therapeutically effective dose range."
|
| DB09282,"Molsidomine leads to smooth muscle relaxation in the coronary blood vessels,"
|
| DB06589,Pazopanib is a synthetic indazolylpyrimidine and reaches steady state concentrations of >15 μg/ml
|
| DB00556,"Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures,"
|
| DB08864,Rilpivirine is a non-nucleoside reverse transcriptase inhibitor that inhibits the replication of HIV-1
|
| DB00204,Dofetilide is an antiarrhythmic drug with Class III (cardiac action potential duration prolonging) properties and is indicated for the maintenance of normal sinus rhythm
|
| DB01020,Isosorbide mononitrate is an anti-anginal agent and vasodilator that relaxes vascular smooth muscle to prevent and manage angina pectoris.
|
| DB01144,"Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma,"
|
| DB00601,Linezolid is an oxazolidinone antibacterial agent effective against most strains of aerobic Gram-positive bacteria and mycobacteria
|
| DB00610,Metaraminol is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure.
|
| DB00866,"Alprenolol is a non-selective beta-blocker used in the treatment of hypertension, edema, ventricular tachycardias,"
|
| DB00697,"**A note on spasticity**Spasticity is an increase in muscle accompanied by uncontrolled,"
|
| DB00968,"Antihypertensive effects of methyldopa are mostly mediated by its pharmacologically active metabolite, alpha-methylnorepinephrine,"
|
| DB01170,High blood pressure can cause the heart and arteries to not function properly.
|
| DB00654,Latanoprost effectively decreases intraocular pressure by increasing uveoscleral outflow.
|
| DB00905,High intraocular pressure is a major risk factor for glaucoma-related visual field loss.
|
| DB02638,"Terlipressin mimics the biological effects of endogenous vasopressin,"
|
| DB09245,This drug has been shown to help manage the symptoms of depression by maintaining neuro-synaptic levels of serotonin and catecholamines while regulating their metabolism
|
| DB08883,Perampanel is involved in inhibiting neuronal excitation in the central nervous system leading to such effects as decreased pyschomotor performance
|
| DB01440,GHB predominantly works at two distinct binding sites in the central nervous system: it works as an agonist at the newly-characterized excitatory GHB receptor
|
| DB06690,"Nitrous oxide, commonly known as ""laughing gas"", is a chemical compound with the chemical formula N2O."
|
| DB01595,Nitrazepam is a type of benzodiazepine drug.
|
| DB00402,Eszopiclone rapidly induces sleep and decreases sleep latency.
|
| DB00807,Proparacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.
|
| DB01178,Chlormezanone is a non-benzodiazepine muscle relaxant.
|
| DB01198,Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia
|
| DB01589,Quazepam is a benzodiazepine derivative.
|
| DB00475,"Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions."
|
| DB00829,"Diazepam is a benzodiazepine that exerts anxiolytic, sedative, muscle- relaxant,"
|
| DB00368,Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction
|
| DB06201,At high concentrations will inhibit action of mGluR5 subtype receptors thus preventing the production of glutamate
|
| DB00590,Doxazosin decreases standing and supine blood pressure and relieves the symptoms of benign prostatic hypertrophy through the inhibition of alpha-1 receptors.
|
| DB00706,"Tamsulosin is an alpha adrenoceptor blocker with specificity for the alpha-1A and alpha-1D subtypes, which are more common in the prostate and submaxillary tissue."
|
| DB01136,Carvedilol reduces tachycardia through beta adrenergic antagonism and lowers blood pressure through alpha-1 adrenergic antagonism
|
| DB00960,Pindolol is a nonselective beta blocker indicated in the management of hypertension and prophylaxis of angina.
|
| DB00887,Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure.
|
| DB00925,Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma.
|
| DB00964,Apraclonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters.
|
| DB00384,"Triamterene, a relatively weak, potassium-sparing diuretic and antihypertensive,"
|
| DB01012,Cinacalcet is a drug that acts as a calcimimetic (i.
|
| DB00736,"Esomeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis,"
|
| DB01159,Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
|
| DB00350,Minoxidil is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance
|
| DB00986,Glycopyrronium is a quaternary ammonium compound that is one of the most commonly prescribed long acting muscarinic antagonists.
|
| DB01403,Methotrimeprazine is a phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine
|
| DB00191,"It is reported that the main mechanism of action of phentermine is the generation of appetite suppression,"
|
| DB09289,Analyses in large-scale epidemiologic surveys have shown that the anxiety disorders are widely comorbid with major depression.
|
| DB00388,"Phenylephrine is an alpha-1 adrenergic agonist that raises blood pressure, dilates the pupils,"
|
| DB00830,Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant.
|
| DB00205,"Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P."
|
| DB01081,"Diphenoxylate, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea."
|
| DB00698,"Nitrofurantoin interferes with vital processes in bacteria, which leads to their death."
|
| DB03615,Ribostamycin is an aminoglycoside antibiotic isolated from _Streptomyces ribosidificus_ listed as one of the World Health Organization's critically important antimicrobials
|
| DB01578,Metrizamide is a radiocontrast agent used to improve the contrast of internal body structures using different imaging techniques such as computed tomography scans (CT) or radiography (X-ray imaging)
|
| DB00684,Tobramycin is an aminoglycoside antibiotic derived from the actinomycete _Streptomyces tenebrarius_.
|
| DB00326,Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium
|
| DB01349,"By blocking the angiotensin II (AT1) receptor, the drug ultimately causes vasodilation, reduced secretion of vasopressin (ADH),"
|
| DB09285,"Morniflumate, given at therapeutic dosages to healthy human volunteers, on leukotriene B4 (LTB4) and thromboxane (TXB2) synthesis,"
|
| DB01013,"Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals."
|
| DB00732,Atracurium is a nondepolarizing skeletal muscle relaxant.
|
| DB01226,"Mivacurium is a short-acting,"
|
| DB00400,Griseofulvin is a mycotoxic metabolic product of <i>Penicillium spp
|
| DB06203,Peak inhibition of DPP-4 occurs within 2-3 hours after a single-dose administration to healthy subjects.
|
| DB06335,"Post-administration of saxagliptin, GLP-1 and GIP levels rise up to 2- to 3- fold."
|
| DB00949,Felbamate is an antiepileptic indicated as monotherapy or as an adjunct to other anticonvulsants for the treatment of partial seizures resulting from epilepsy
|
| DB01348,Spirapril is an angiotensin-converting enzyme (ACE) inhibitor.
|
| DB05265,Ecabet is a prescription eye drop for the treatment of dry eye syndrome
|
| DB06717,Fosaprepitant is a prodrug of Aprepitant.
|
| DB00776,Oxcarbazepine is an anticonvulsant drug that reduces the incidence of seizures in epilepsy by inhibiting abnormal electrical activity in the brain
|
| DB00982,The pharmacodynamics of isotretinoin are poorly understood
|
| DB08899,Enzalutamide is a second-generation antiandrogen that blocks the activity of androgen and androgen receptor (AR) in prostate cancer
|
| DB01656,"Roflumilast and its active metabolite, roflumilast N-oxide, increase cyclic adenosine-3′,"
|
| DB12267,Brigitanib inhibits proliferation and in vitro viability of cells expressing the fusion protein EML4-ALK as well as 17 crizotinib-resistant ALK mutants.
|
| DB09449,Sodium phosphate inceases fecal water content to increase mobility through the large intestine
|
| DB08822,"Pharmacodynamic effects of azilsartan medoxomil are mediated by its active metabolite, azilsartan."
|
| DB09295,"Talniflumate is metabolized to its prodrug, niflumic acid, which has several pharmacodynamic effects."
|
| DB00353,Methylergometrine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage.
|
| DB00589,"There is evidence that lisuride lowers prolactin levels and, in low doses,"
|
| DB00699,Nicergoline is a potent vasodilator (improves brain blood flow).
|
| DB06207,Silodosin is an antagonist of α<sub>1</sub>-adrenoceptors.
|
| DB06820,The function of imidazole derivatives can be attributed to their structural resemblance to purines essential to metabolism
|
| DB00793,Used as a topical ointment or cream in the treatment of Tinea infections.
|
| DB01422,Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections.
|
| DB00646,Nystatin is an antifungal that is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi
|
| DB00639,Butoconazole is an imidazole derivative that has fungicidal activity <i>in vitro</i> against <i>Candida</i> spp.
|
| DB00937,Diethylpropion is a sympathomimetic stimulant drug marketed as an appetite suppressant.
|
| DB00283,Clemastine is an antihistamine that also induces anticholinergic and sedative effects.
|
| DB01296,"The administration of glucosamine, in theory, provides a building block towards the synthesis of glycosaminoglycans,"
|
| DB00248,Cabergoline stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects.
|
| DB01092,"Ouabain, a cardiac glycoside similar to digitoxin,"
|
| DB00247,"Methysergide has been shown, <i>in vitro</i> and <i>in vivo</i>, to inhibit or block the effects of serotonin,"
|
| DB01180,Used to treat hypertension.
|
| DB06263,"The _anthracycline glycoside_ group of antibiotics, which includes amrubicin,"
|
| DB00997,Doxorubicin is an antineoplastic in the anthracycline class
|
| DB01172,Kanamycin is an aminoglycoside antibiotic.
|
| DB00798,Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963.
|
| DB06696,Arbekacin is an aminoglycoside.
|
| DB01421,Paromomycin is a broad spectrum aminoglycoside antibiotic produced by <i>Streptomyces rimosus</i> var.
|
| DB00452,Framycetin is used for the treatment of bacterial eye infections such as conjunctivitis.
|
| DB00448,"Lansoprazole decreases gastric acid secretion by targeting H+,K+-ATPase, which is the enzyme that catalyzes the final step in the acid secretion pathway in parietal cells."
|
| DB00955,"Netilmicin is a semisynthetic, water soluble antibiotic of the aminoglycoside group, produced by the fermentation of Micromonospora inyoensis, a species of actinomycete."
|
| DB00656,Trazodone treats depressed mood and other depression-related symptoms and shows benefit in the treatment of insomnia due to its sedating effects.
|
| DB01563,A hypnotic and sedative used in the treatment of insomnia.
|
| DB01028,Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia.
|
| DB06716,"Fospropofol is a prodrug of propofol, a sedative hypnotic drug."
|
| DB01463,Fencamfamine increases drive and mental alertness and an elevation of mood and a general feeling of well-being.
|
| DB00405,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
|
| DB00404,"Alprazolam is a benzodiazepine that binds γ-aminobutyric acid (GABA) type-A receptors (GABA<sub>A</sub>Rs) to enhance their inhibitory effect on neurotransmission,"
|
| DB01558,"Bromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties."
|
| DB06594,Agomelatine resynchronises circadian rhythms in animal models of delayed sleep phase syndrome and other circadian rhythm disruptions
|
| DB13323,"Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane,"
|
| DB00721,"Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery."
|
| DB01239,Chlorprothixene is a typical antipsychotic drug of the thioxanthine class.
|
| DB00628,Clorazepate is a member of the group of drugs called benzodiazepines.
|
| DB01624,Zuclopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics.
|
| DB00490,The clinical effect of buspirone in alleviating the symptoms of generalized anxiety disorders typically takes 2 to 4 weeks to achieve
|
| DB00186,The effect of lorazepam in GABA-A receptors produces an increase in the frequency of opening of the chloride ion channel.
|
| DB00297,Bupivacaine is a widely used local anesthetic agent.
|
| DB00645,Dyclonine is an oral anasthetic.
|
| DB00391,Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist indicated to treat acute and chronic schizophrenia
|
| DB01618,"Molindone is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones,"
|
| DB01086,Benzocaine is indicated for use as a topical anesthetic.
|
| DB09166,"Etizolam is a CNS depressant with anxiolytic, anticonvulsant,"
|
| DB06144,Sertindole is an atypical antipsychotic at least as effective as haloperidol and risperidone in the treatment of neuroleptic-responsive schizophrenia.
|
| DB00385,Valrubicin is an anticancer agent.
|
| DB00428,Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine
|
| DB01253,Ergonovine belongs to the group of medicines known as ergot alkaloids.
|
| DB00327,In clinical trials
|
| DB01356,"Although lithium has been used for over 50 years in treatment of bipolar disorder,"
|
| DB00854,Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
|
| DB00890,Estrogens diffuse into their target cells and interact with a protein receptor.
|
| DB00479,Amikacin is an aminoglycoside antibiotic.
|
| DB06810,Plicamycin is lethal to Hela cells in 48 hours at concentrations as low as 0.
|
| DB00919,Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as S<i>treptomyces spectabilis</i>
|
| DB00738,Pentamidine is an antiprotozoal agent.
|
| DB01188,Ciclopirox is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties.
|
| DB00525,Tolnaftate is a synthetic over-the-counter anti-fungal agent
|
| DB01157,"Trimetrexate, a non-classical folate antagonist, is a synthetic inhibitor of the enzyme dihydrofolate reductase (DHFR)."
|
| DB09040,mean ± SD plasma Cmax on Day 28 of treatment: 0.
|
| DB01153,Sertaconazole is an imidazole/triazole type antifungal agent.
|
| DB01034,Cerulenin is an antifungal antibiotic isolated from <i>Cephalosporium caerulens</i>.
|
| DB08958,A bactericidal and fungicidal antiseptic.
|
| DB00864,Tacrolimus acts by reducing peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex.
|
| DB01177,Idarubicin is an antineoplastic in the anthracycline class
|
| DB06228,Rivaroxaban is an anticoagulant which binds directly to factor Xa.
|
| DB01036,Tolterodine is a competitive muscarinic receptor antagonist.
|
| DB04953,"As compared to other antiepileptic agents, ezogabine is unique in that it selectively activates potassium ion channels Kv 7."
|
| DB00366,Doxylamine is an antihistamine commonly used as a sleep aid.
|
| DB00334,"The effect of olanzapine in the D2 receptor is reported to produce the positive effects of this drug such as a decrease in hallucinations, delusions, disorganized speech,"
|
| DB00408,"Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines."
|
| DB06699,"Degarelix is a synthetic derivative of GnRH decapeptide, the ligand of the GnRH receptor."
|
| DB01099,Flucytosine is an antimetabolite that acts as an antifungal agent with <i>in vitro</i> and <i>in vivo</i> activity against Candida and Cryptococcus.
|
| DB06695,Dabigatran etexilate is a double prodrug that is hydrolyzed to the active by intestinal and hepatic carboxylesterases
|
| DB00938,Salmeterol is a long acting beta-2 adrenergic receptor agonist that binds to both the active and exo sites of the beta-2 adrenergic receptor
|
| DB01064,"Isoprenaline is a non-selective beta adrenergic receptor agonist used in a number of indications for the heart,"
|
| DB09031,Little is known about the clinical pharmacodynamics of miltefosine and other antileishmanial drugs
|
| DB00362,Anidulafungin is a semi-synthetic lipopeptide synthesized from a fermentation product of <i>Aspergillus nidulans</i>.
|
| DB01007,Tioconazole is a broad-spectrum imidazole antifungal agent that inhibits the growth of human pathogenic yeasts.
|
| DB03793,A fungistatic compound that is widely used as a food preservative.
|
| DB00239,"Oxiconazole is a broad-spectrum imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis,"
|
| DB01406,"Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone."
|
| DB04876,Vildagliptin works to improve glycemic control in type II diabetes mellitus by enhancing the glucose sensitivity of beta-cells (β-cells) in pancreatic islets and promoting glucose-dependent insulin secretion
|
| DB04920,Clevidipine belongs to a well-known class of drugs called dihydropyridine calcium channel antagonists.
|
| DB06412,"Oxymetholone is a synthetic anabolic steroid marketed under the brand name Anapolon by Hoffmann La Roche Limitedand used in the treatment of osteoporosis,"
|
| DB01185,"Fluoxymesterone is a synthetic androgen, or male hormone,"
|
| DB01141,"Formerly known as FK463,"
|
| DB01243,"Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms."
|
| DB00126,"Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy."
|
| DB04894,Vapreotide is a somatostatin analog with a higher metabolic stability than the parent hormone.
|
| DB09183,Dasabuvir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotype 1
|
| DB06767,Systemic acidifier.
|
| DB01275,Hydralazine interferes with calcium transport to relax arteriolar smooth muscle and lower blood pressure.
|
| DB01090,Pentolinium acts as a ganglionic blocking agent.
|
| DB01214,"Metipranolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant,"
|
| DB00940,"Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder."
|
| DB09300,Scopolamine butylbromide is a muscarinic antagonist which acts to prevent acetylcholine-stimulated contraction of smooth muscle in the gastrointestinal tract
|
| DB00747,"Scopolamine is an anticholinergic belladonna alkaloid that,"
|
| DB00376,Trihexyphenidyl is an antimuscarinic indicated as an adjunct in the treatment of parkinsonism or as a treatment for drug-induced extrapyramidal symptoms
|
| DB00979,Cyclopentolate is an anti-muscarinic in the same class as atropine and scopolamine.
|
| DB00983,"Formoterol works locally in the lungs as a bronchodilator,"
|
| DB00221,Isoetharine is a relatively selective beta2-adrenergic bronchodilator.
|
| DB01409,Tiotropium is a long acting antimuscarinic that causes bronchodilation
|
| DB00572,Atropine is an antimuscarinic agent that antagonizes the effects of acetylcholine.
|
| DB08897,Aclidinium does not prolong the QTc interval or have significant effects on cardiac rhythm
|
| DB12278,Propiverine hydrochloride inhibits abnormal contractions of bladder smooth muscle in vivo through not only its anticholinergic activity but also its concurrent calcium antagonistic activity .
|
| DB00804,Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines
|
| DB00867,"Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus."
|
| DB01366,Procaterol is a long-acting beta-2-adrenergic receptor agonist.
|
| DB11315,Methscopolamine bromide is an anticholinergic agent which possesses most of the pharmacologic actions of that drug class.
|
| DB00424,"Hyoscyamine is not FDA approved, and so it has not official indications."
|
| DB06702,"In-vivo the fesoteridine prodrug is broken down into its active metabolite, 5-hydroxymethyl tolterodine (5-HMT), by plasma esterases."
|
| DB01338,Pipecuronium is a nondepolarizing neuromuscular blocking agent.
|
| DB00392,"Ethopropazine, a phenothiazine and antidyskinetic, is used in the treatment of Parkinson's disease."
|
| DB01173,"Orphenadrine is indicated as an adjunct to rest, physical therapy,"
|
| DB00332,Ipratropium is a short-acting agent that inhibits the parasympathetic nervous system at the level of the airway which then produces bronchodilatation
|
| DB00245,The inhibition of dopamine reuptake by benztropine produces a dose-dependent increase of dopamine in the nerve terminal of the dopaminergic system
|
| DB01337,Pancuronium is a non-depolarising muscle relaxant similar to curare.
|
| DB00340,Metixene is a tertiary antimuscarinic with actions similar to those of atropine
|
| DB00219,"Oxyphenonium is an anticholinergic drug, a medication that reduces the effect of acetylcholine,"
|
| DB00898,Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm.
|
| DB00871,Terbutaline is a beta-2 adrenergic receptor agonist indicated to treat reversibly bronchospasm in asthmatic patients with bronchitis and emphysema
|
| DB00700,"Eplerenone, an aldosterone receptor antagonist similar to spironolactone,"
|
| DB01339,The principal pharmacologic effects demonstrated by vecuronium revolve around its competitive binding of cholinergic receptors located at motor end plates
|
| DB09076,Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD)
|
| DB01062,"Oxybutynin exerts antispasmodic actions on the bladder, relieving the uncomfortable symptoms of overactive bladder, including urinary urgency and frequency."
|
| DB00462,Methscopolamine is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic
|
| DB00782,"Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine,"
|
| DB00670,Pirenzepine belongs to a group of medications called antispasmodics/anticholinergics.
|
| DB00809,Tropicamide is an anticholinergic drug and that works by non‐selectively blocking muscarinic receptors to cause mydriasis and cycloplegia.
|
| DB00209,"Trospium is an antispasmodic, antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency."
|
| DB00319,"Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
|
| DB01147,Cloxacillin is a semisynthetic antibiotic in the same class as penicillin.
|
| DB00529,Foscarnet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses <i>in vitro</i> including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2)
|
| DB01604,Pivampicillin is the pivaloyloxymethyl ester of (the semi-synthetic penicillin) ampicillin.
|
| DB00903,Ethacrynic acid is a monosulfonamyl loop or high ceiling diuretic.
|
| DB01605,"Pivmecillinam is a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally,"
|
| DB01061,"Similar to and ,"
|
| DB00485,Dicloxacillin is a beta-lactamase resistant penicillin similar to oxacillin.
|
| DB09324,"Sulbactam is a β-lactamase inhibitor given in combination with β-lactam antibiotics to inhibit β-lactamase,"
|
| DB00361,Vinorelbine is a semi-synthetic vinca-alkaloid with a wide spectrum of anti-tumor activity.
|
| DB00515,Cisplatin is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
|
| DB11613,Velpatasvir is a small molecule direct-acting antiviral used in the treatment of hepatitis C in combination with sofosbuvir.
|
| DB03796,Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced
|
| DB00512,"Vancomycin is a branched tricyclic glycosylated nonribosomal peptide often reserved as the ""drug of last resort"","
|
| DB00713,"Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive,"
|
| DB01607,Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.
|
| DB00314,Capreomycin is a member of the aminoglycoside family of antibiotics.
|
| DB08807,Bopindolol is a prodrug of pindolol
|
| DB06715,It works in the thyroid gland.
|
| DB01195,"Flecainide inhibits the action of sodium and potassium ion channels in the heart, raising the threshold for depolarization and correcting arrhythmias."
|
| DB09570,In vitro studies have shown ixazomib to induce apoptosis in multiple myeloma cells sensitive or resistant to other conventional therapies.
|
| DB00146,Calcidiol is the precursor of vitamin D3.
|
| DB09296,Ombitasvir is classified as a direct acting antiviral and acts against HCV to inhibit viral replication
|
| DB01336,"Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant."
|
| DB00565,The dose required to produce 95% suppression of twitch response to nerve stimulation (ED<sub>95</sub>) of cisatracurium is 0.
|
| DB00892,Oxybuprocaine is a local anaesthetic.
|
| DB00897,A short-acting benzodiazepine used as a hypnotic agent in the treatment of insomnia.
|
| DB00750,Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell.
|
| DB00842,"Benzodiazepines, including oxazepam, exert their sedative and anxiolytic effects by potentiating the effects of endogenous GABA, the primary inhibitory neurotransmitter in the CNS."
|
| DB00962,Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia
|
| DB00228,Enflurane rapidly induces anesthesia via the stimulation of inhibitory neural channels and the inhibition of excitatory neural channels.
|
| DB00918,Almotriptan is a selective 5-hydroxytryptamine receptor subtype agonist indicated for the acute treatment of migraine attacks with or without aura in adults
|
| DB00952,Naratriptan is a selective agonist of serotonin (5-hydroxytryptamine
|
| DB09072,"Sodium oxybate works to improve nocturnal sleep, improve alertness the following day,"
|
| DB00409,Remoxipride is a weak selective dopamine D<sub>2</sub> receptor antagonist that was once used in the treatment of schizophrenia.
|
| DB01215,"Estazolam, a triazolobenzodiazepine derivative, is an oral hypnotic agent with anticonvulsant, hypnotic,"
|
| DB01353,Butethal (also known as butobarbitone and butobarbital) belongs to a group of medicines called the barbiturates
|
| DB01161,Chloroprocaine is an ester local anesthetic agent indicated for the production of local or regional anesthesia with effects on the cardiovascular and central nervous systems.
|
| DB08815,Lurasidone is a benzothiazol derivative that is an antagonist and binds with high affinity to Dopamine-2 (D2).
|
| DB09042,Tedizolid is an oxazolidinone antibiotic that works by inhibiting protein synthesis by bacterial ribosomes.
|
| DB00387,Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle.
|
| DB00371,Meprobamate is an anxiolytic drug.
|
| DB00237,Butabarbital potentiates GABAergic neurons while inhibiting neuronal acetylcholine and glutamate receptors to produce sedation.
|
| DB09224,Melperone has been demonstrated to produce an antipsychotic effect at doses that cause minimal extrapyramidal symptoms frequently associated with more traditional antipsychotics
|
| DB00189,Ethchlorvynol is a sedative drug and schedule IV (USA) controlled substance.
|
| DB00298,Dapiprazole is an alpha-adrenergic blocking agent.
|
| DB08922,Perospirone is a serotonin 5-HT2 receptor inverse agonist and dopamine D2 receptor antagonist based on receptor binding experiments that binds to both receptors with high affinity
|
| DB06216,"Asenapine is a serotonin, dopamine, noradrenaline,"
|
| DB06288,Amisulpride is a selective dopamine D2 and D3 receptor antagonist with no affinity towards other dopamine receptor subtypes
|
| DB01623,Thiothixene is an antipsychotic of the thioxanthene series.
|
| DB00927,"Famotidine decreases the production of gastric acid, suppresses acid concentration and pepsin content, and decreases the volume of gastric secretion."
|
| DB04842,Fluspirilene is a relatively long-acting injectable depot antipsychotic drug used for schizophrenia.
|
| DB08941,A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
|
| DB06152,"Nylidrin hydrochloride acts mainly by beta-receptor stimulation , ."
|
| DB00723,Methoxamine is a potent sympathomimetic amine that increases both systolic and diastolic blood pressure.
|
| DB00819,"Acetazolamide is a potent carbonic anhydrase inhibitor,"
|
| DB00211,"Midodrine is a prodrug, i."
|
| DB06764,Tetryzoline is a sympathomimetic amine and an alpha-adrenergic agonist with vasoconstricting and decongestant properties
|
| DB00142,"In addition to being one of the building blocks in protein synthesis,"
|
| DB00875,Flupentixol is an antipsychotic agent with anxiolytic and mild sedative actions.
|
| DB13025,Tiapride has a high degree of regional selectivity for limbic areas
|
| DB00470,Dronabinol-induced sympathomimetic activity may result in tachycardia and/or conjunctival injection.
|
| DB06016,Cariprazine is an antipsychotic agent.
|
| DB01288,Fenoterol is a beta agonist designed to open up the airways to the lungs by decreasing bronchconstriction
|
| DB01364,Ephedrine increases blood pressure by stimulating heart rate and cardiac output and variably increasing peripheral resistance.
|
| DB00988,"Dopamine is a natural catecholamine formed by the decarboxylation of 3,"
|
| DB01621,Pipotiazine has actions similar to those of other phenothiazines.
|
| DB01365,Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors.
|
| DB06799,Ingestion of a 1-gram dose of methenamine hippurate produces antibacterial activity in the urine within 1/2 hour.
|
| DB06148,"Mianserin is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect."
|
| DB01235,Levodopa is able to cross the blood-brain barrier while dopamine is not
|
| DB09225,"In preclinical studies,"
|
| DB01255,Lisdexamfetamine dimesylate is a prodrug of _d-amphetamine_.
|
| DB09209,"The therapeutic doses of pholcodine have been shown not to cause depression of respiration,"
|
| DB09128,"Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors,"
|
| DB00184,"Nicotine, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain."
|
| DB00170,Menadione (Vitamin K3) is a fat-soluble vitamin precursor that is converted into menaquinone in the liver.
|
| DB00553,Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA).
|
| DB00317,"Gefitinib inhibits the intracellular phosphorylation of numerous tyrosine kinases associated with transmembrane cell surface receptors,"
|
| DB01219,Dantrolene is classified as a direct-acting skeletal muscle relaxant.
|
| DB00909,"By stopping the spread of seizure discharges,"
|
| DB04946,Iloperidone shows high affinity and maximal receptor occupancy for dopamine D2 receptors in the caudate nucleus and putamen of the brains of schizophrenic patients
|
| DB00425,"**Effects on the central nervous system (CNS)**This drug has CNS depressant effects, which may include somnolence, decreased alertness, sedation, drowsiness, dizziness,"
|
| DB00889,Granisetron is a selective inhibitor of type 3 serotonergic (5-HT<sub>3</sub>) receptors.
|
| DB01074,Used in the treatment of unresponsive or refractory angina.
|
| DB06292,Dapagliflozin inhibits the sodium-glucose contransporter 2(SGLT2) which is primarily located in the proximal tubule of the nephron
|
| DB04572,The unstable nitrogen-carbon groups alkylate with DNA causing irrepairable DNA damage.
|
| DB05109,Two of the rings in the drug's structure allows it to covalently bind to the minor groove of DNA
|
| DB00762,Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer.
|
| DB00307,Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs).
|
| DB05381,"Histamine stimulates gastric gland secretion,"
|
| DB00643,Mebendazole is a (synthetic) broad-spectrum anthelmintic.
|
| DB01559,"Clotiazepam is a thienodiazepine possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties."
|
| DB08901,Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia.
|
| DB00234,"Reboxetine is a selective noradrenaline reuptake inhibitor (NaRI), the first drug of new antidepressant class."
|
| DB06654,Safinamide is for the treatment of parkinson's disease.
|
| DB01424,"Aminophenazone exhibits analgesic, anti-inflammatory,"
|
| DB00546,"Adinazolam is a benzodiazepine derivative used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia."
|
| DB04835,Maraviroc is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5
|
| DB12161,In clinical trials
|
| DB00230,"Although the structure of pregabalin is similar to gamma-aminobutyric acid (GABA), it does not bind to GABA receptors."
|
| DB01165,Ofloxacin is a quinolone/fluoroquinolone antibiotic.
|
| DB08903,Bedaquiline is primarily subjected to oxidative metabolism leading to the formation of N-monodesmethyl metabolite (M2)
|
| DB00308,"Ibutilide prolongs the action potential duration and increases both atrial and ventricular refractoriness in vivo, i."
|
| DB01218,Halofantrine is a synthetic antimalarial which acts as a blood schizonticide.
|
| DB01005,Hydroxyurea has dose-dependent synergistic activity with cisplatin <i>in vitro</i>.
|
| DB06701,Dexmethylphenidate is the d-enantiomer of methylphenidate.
|
| DB04938,The half maximal inhibitory concentration (IC50) for estrogen receptor (ER) alpha and beta are 0.
|
| DB00494,"Entacapone is structurally and pharmacologically related to tolcapone, but unlike tolcapone,"
|
| DB00757,"Dolasetron is a highly specific and selective serotonin 5-HT<sub>3</sub> receptor antagonist,"
|
| DB01576,"Dextroamphetamine is a noncatecholamine, sympathomimetic amine that acts as a CNS stimulant."
|
| DB00792,Used to treat the effects of colds and allergies.
|
| DB09396,Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company.
|
| DB06819,Phenylbutyric acid decreases elevated plasma ammonia glutamine levels in patients with urea cycle disorders.
|
| DB01426,Ajmaline is a class 1A antiarrhythmic agent.
|
| DB00222,Glimepiride stimulates the secretion of insulin granules from the pancreatic beta cells and improves the sensitivity of peripheral tissues to insulin to increase peripheral glucose uptake
|
| DB09278,Activated charcoal is used as a gastric decontamination agent in emergency clinical settings in case of poison or medication overdose
|
| DB01206,Lomustine is an alkylating agent of the nitrosourea type.
|
| DB00888,"Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug."
|
| DB01008,Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
|
| DB00958,Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.
|
| DB01042,Melphalan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer
|
| DB00563,Methotrexate inhibits enzymes responsible for nucleotide synthesis which prevents cell division and leads to anti-inflammatory actions
|
| DB00250,Dapsone is a sulfone with anti-inflammatory immunosuppressive properties as well as antibacterial and antibiotic properties
|
| DB04841,Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity
|
| DB12532,Oxetacaine improves common gastrointestinal symptoms
|
| DB08872,"Since gabapentin enacarbil is a prodrug of gabapentin, it's physiological effects are the same as gabapentin."
|
| DB11148,Butamben has been shown to selectively inhibit dorsal root pain signal transmission for periods of months when administered as epidural suspensions
|
| DB06282,Levocetirizine is a second generation histamine H<sub>1</sub> antagonist used to treat various allergic symptoms.
|
| DB01065,Melatonin is a hormone normally produced in the pineal gland and released into the blood.
|
| DB04844,Prolongation of the QTc interval has been observed at doses of 50 mg.
|
| DB08910,Pomalidomide is more potent than thalidomide (100-times) and lenalidomide (10-times)
|
| DB00427,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
|
| DB01545,This compound belongs to the class of organic compounds known as alpha amino acid esters.
|
| DB09352,Hydroxyamphetamine is a derivative of amphetamines.
|
| DB00989,Rivastigmine is a parasympathomimetic and a reversible cholinesterase inhibitor
|
| DB00517,Anisotropine methylbromide is a quaternary ammonium compound.
|
| DB09017,Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog.
|
| DB00801,"Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects."
|
| DB01544,Flunitrazepam is a powerful hypnotic drug that is a benzodiazepine derivative.
|
| DB00996,"Gabapentin is an anti-convulsant medication that inhibits the release of excitatory neurotransmitters,"
|
| DB01588,"Prazepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant activity."
|
| DB00998,Frovatriptan is a second generation triptan 5-HT receptor agonist that binds with high affinity for 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> receptors.
|
| DB00704,"Naltrexone, a pure opioid antagonist,"
|
| DB00683,**General effects**Midazolam is a short-acting benzodiazepine central nervous system (CNS) depressant.
|
| DB01511,"Delorazepam is a benzodiazepine which, like other drugs in its class, possesses anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties."
|
| DB00916,"Metronidazole treats amebiasis, trichomoniasis, and giardiasis, exerting both antibacterial and antiprotozoal activities."
|
| DB00218,Moxifloxacin is a quinolone/fluoroquinolone antibiotic.
|
| DB00315,"Zolmitriptan, like other triptans, is a serotonin (5-hydroxytryptamine; 5-HT) receptor agonist,"
|
| DB00967,Desloratadine is a long-acting second-generation H<sub>1</sub>-receptor antagonist which has a selective and peripheral H1-antagonist action
|
| DB09068,Vortioxetine binds with high affinity to the human serotonin transporter.
|
| DB09085,Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch
|
| DB08987,Etidocaine is marketed under the name Duranest.
|
| DB01325,Quinethazone is a thiazide diuretic used to treat hypertension.
|
| DB00961,Mepivicaine is an amide local anesthetic.
|
| DB00231,Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia .
|
| DB00202,Succinylcholine's neuromuscular blockade takes effect within 60 seconds of intravenous administration and lasts between four to six minutes.
|
| DB00241,"Butalbital is a short to intermediate-acting barbiturate that reversibly depresses the activity of excitable tissues,"
|
| DB00423,Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action.
|
| DB00906,Tiagabine is used primarily as an anticonvulsant for the adjunctive treatment of epilepsy.
|
| DB01106,Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils
|
| DB01202,"Levetiracetam appears to prevent seizure activity via the selective inhibition of hypersynchronized epileptiform burst firing without affecting normal neuronal transmission,"
|
| DB00985,"Dimenhydrinate is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness."
|
| DB01176,Cyclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent.
|
| DB01501,Difenoxin acts as a potent antidiarrheal by slowing the movement of the intestines
|
| DB00150,"Tryptophan is critical for the production of the body's proteins, enzymes and muscle tissue."
|
| DB05246,Used in the treatment of epilepsy
|
| DB00835,Brompheniramine is an antihistaminergic medication of the propylamine class.
|
| DB01567,Fludiazepam is a benzodiazepine derivative.
|
| DB01587,"Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant and amnesic action."
|
| DB09009,Articaine is a dental local anesthetic.
|
| DB00377,Palonosetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting
|
| DB11699,Tropisetron is an indole derivative with antiemetic activity.
|
| DB09041,"After a single dose, the mean (± standard deviation) peak concentration (Cmax) of tavaborole was 3."
|
| DB01091,Butenafine is a synthetic antifungal agent that is structurally and pharmacologically related to allylamine antifungals.
|
| DB01194,"Used in the treatment of glaucoma,"
|
| DB06153,Various studies have shown pizotifen to be effective in the prophylaxis of migraines in reducing the frequency and severity of vascular headaches
|
| DB09345,"Pramocaine temporarily relieves pain, pruritis,"
|
| DB00980,Ramelteon is the first selective melatonin agonist.
|
| DB00445,Epirubicin is an antineoplastic in the anthracycline class
|
| DB01082,"Although streptomycin originally had broad gram-negative and gram-positive coverage,"
|
| DB01035,"Procainamide is an agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation,"
|
| DB01111,Colistimethate is a polymyxin antibiotic agent.
|
| DB09090,Pinaverium is a selective and specific voltage-dependent calcium channel blocker located on intestinal smooth muscle cells to inhibit calcium influx
|
| DB01427,"Amrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity,"
|
| DB00884,Risedronate is a pyridine-based bisphosphonate that inhibits bone resorption caused by osteoclasts
|
| DB01627,Lincomycin is a lincosamide antibiotic derived as a natural fermentation product from _Streptomyces lincolnensis_.
|
| DB00781,"Polymyxin B is an antibiotic that disrupts the outer cell membrane of Gram negative bacteria, binds and neutralizes lipopolysaccharide,"
|
| DB06147,Sulfathiazole is a short-acting sulfa drug.
|
| DB00660,"Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute,"
|
| DB00455,"Like other 2nd generation antihistamines, loratadine is selective for peripheral H1 receptors."
|
| DB00356,Chlorzoxazone is a centrally-acting agent for painful musculoskeletal conditions
|
| DB01223,Aminophylline is the ethylenediamine salt of theophylline.
|
| DB00251,Terconazole is a triazole antifungal agent available for intravaginal use.
|
| DB00877,Sirolimus is an immunosuppressant drug with antifungal and antitumour effects.
|
| DB00737,"Meclizine works on the higher centres of the brain to reduce nausea, vomiting, or vertigo."
|
| DB00593,Used in the treatment of epilepsy
|
| DB00181,Baclofen is an antispasmodic agent that induces muscle relaxation.
|
| DB06770,Benzyl alcohol is an antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older
|
| DB09099,"Somatostatin is an endogenous peptide hormone that is secreted by the central nervous system, gastrointestinal tract, retina,"
|
| DB00165,"Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide,"
|
| DB04908,Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015
|
| DB00395,Carisoprodol is a centrally acting skeletal muscle relaxant that does not act directly on skeletal muscle but acts directly on the central nervous system (CNS)
|
| DB01083,Orlistat helps with weight reduction and maintenance by inhibiting the absorption of dietary fats via the inhibition of lipase enzymes
|
| DB08882,A 5mg oral dose of linagliptin results in >80% inhibition of dipeptidyl peptidase 4 (DPP-4) for ≥24 hours.
|
| DB04794,Bifonazole is a type of antifungal medicine known as an imidazole.
|
| DB00555,"Lamotrigine likely prevents seizures and prevents mood symptoms via stabilizing presynaptic neuronal membranes and preventing the release of excitatory neurotransmitters such as glutamate,"
|
| DB00651,"Dyphylline, a xanthine derivative,"
|
| DB09342,Propoxycaine is a local anesthetic which acts to decrease nerve impulses and therefore pain sensation during dental procedures
|
| DB00341,"**General effects and respiratory effects**Cetirizine, the active metabolite of the piperazine H<sub>1</sub>-receptor antagonist hydroxyzine, minimizes or eliminates the symptoms of chronic idiopathic urticaria, perennial allergic rhinitis,"
|
| DB13872,Lormetazepam is a benzodiazepine which reduces central nervous system (CNS) activity .
|
| DB01080,Vigabatrin is an antiepileptic agent chemically unrelated to other anticonvulsants.
|
| DB08992,"Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia,"
|
| DB00309,Vindesine is indicated for the treatment of acute lymphocytic leukemia of childhood that is resistant to vincristine and non-oat cell lung cancer
|
| DB00434,"Cyproheptadine has been observed to antagonize several pharmacodynamic effects of serotonin in laboratory animals, including bronchoconstriction and vasodepression,"
|
| DB08943,Isoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections
|
| DB01205,Flumazenil antagonizes the CNS effects produced by benzodiazepines
|
| DB00527,"Dibucaine is an amide-type local anesthetic,"
|
| DB01210,"Levobunolol is an ophthalmic beta-blocker, equally effective at β(1)- and β(2)-receptor sites."
|
| DB06791,"Lanreotide exhibits antisecretory effects through cAMP suppression,"
|
| DB00817,Rosoxacin is a nonfluorinated quinolone antibiotic.
|
| DB05316,Pimavanserin's unique actions on serotonin receptors improve symptoms of hallucinations and delusions associated with Parkinson's disease.
|
| DB09223,Blonanserin antagonizes dopamine and serotonin receptors to reduce symptoms of schizophrenia
|
| DB00771,Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract
|
| DB00650,"Leucovorin is one of several active, chemically reduced derivatives of folic acid."
|
| DB00826,Natamycin is an antifungal drug for topical ophthalmic administration.
|
| DB00604,"Cisapride is a parasympathomimetic which acts as a serotonin 5-HT<sub>4</sub> agonist; upon activation of the receptor signaling pathway,"
|
| DB04861,"Nebivolol is a selective beta-1 adrenergic receptor antagonist that decreases vascular resistance, increases stroke volume and cardiac output,"
|
| DB01113,Papaverine is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias
|
| DB00568,Cinnarizine is an antihistamine and a calcium channel blocker.
|
| DB11235,Thonzylamine is a first-generation antihistamine.
|
| DB09488,Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever.
|
| DB08799,Antazoline is a histamine H1 receptor antagonist.
|
| DB04898,"Ximelagatran is an anticoagulant intended to become a replacement for warfarin by overcoming the dietary restrictions, drug interaction, and monitoring issues associated with the former."
|
| DB01597,Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.
|
| DB09230,Azelnidipine is a vasodilator that induces a gradual decrease in blood pressure in hypertensive patients.
|
| DB06824,Triethylenetetramine (TETA) is a selective copper(II) chelator that works to promote urinary copper excretion.
|
| DB09026,Aliskiren reduces blood pressure by inhibiting renin.
|
| DB08808,"Bupranolol is a competitive,"
|
| DB01359,"Penbutolol is a ß-1, ß-2 (nonselective) adrenergic receptor antagonist."
|
| DB09034,Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal.
|
| DB08931,Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA
|
| DB06826,Unoprostone will begin to reduce IOP 30 minutes after ocular instillation
|
| DB00765,"In patients with pheochromocytoma,"
|
| DB02513,A phenol obtained from thyme oil or other volatile oils.
|
| DB06718,"Stanozolol is a synthetic anabolic-androgenic steroid (AAS),"
|
| DB09038,"Empagliflozin lowers blood glucose levels by preventing glucose reabsorption in the kidneys,"
|
| DB00284,"Acarbose is a complex oligosaccharide that competitively inhibits the ability of brush-border alpha-glucosidase enzymes to break down ingested carbohydrates into absorbable monosaccharides,"
|
| DB09083,"The funny channels (If) open during repolarization and close during depolarization,"
|
| DB00823,Ethynodiol Diacetate is used as a female contraceptive.
|
| DB06788,Histrelin inhibits gonadotropin secretion through the reversible down-regulation of gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and desensitization of the pituitary gonadotropes
|
| DB00731,Insulin secretion by pancreatic β cells is partly controlled by cellular membrane potential
|
| DB00331,**General effects**Insulin is an important hormone that regulates blood glucose levels.
|
| DB01044,Gatifloxacin is a synthetic broad-spectrum 8-methoxyfluoroquinolone antibacterial agent for oral or intravenous administration
|
| DB01261,"Sitagliptin inhibits DPP-4 which leads to increased levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), decreased levels of glucagon,"
|
| DB01252,Mitiglinide belongs to the meglitinide class of blood glucose-lowering drugs.
|
| DB04878,"Voglibose, an alpha-glucosidase inhibitor, is a synthetic compound with potent and enduring therapeutic efficacies against disorders of sensory,"
|
| DB06402,"Telavancin is a semi-synthetic derivative of vancomycin, therefore the mode of bactericidal action is similar to vancomycin in which both antibiotics inhibit cell wall synthesis."
|
| DB00672,"Chlorpropamide, a second-generation sulfonylurea antidiabetic agent,"
|
| DB00166,Lipoic acid (or &alpha
|
| DB00467,Enoxacin is a quinolone/fluoroquinolone antibiotic.
|
| DB00627,"Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia,"
|
| DB00491,"Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates,"
|
| DB00912,Insulin secretion by pancreatic &beta
|
| DB00827,"Cinoxacin is a synthetic antibacterial agent with <i>in vitro</i> activity against many gram-negative aerobic bacteria, particularly strains of the Enterobacteriaceae family."
|
| DB01612,"Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator."
|
| DB00592,"Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms,"
|
| DB01030,"Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the <i>Camptotheca acuminata</i> tree),"
|
| DB08911,"Trametinib is an anticancer agent which causes apoptosis (or programmed cell death) and inhibits cell proliferation,"
|
| DB00856,Chlorphenesin is a muscle relaxant.
|
| DB00419,"Miglustat, an N-alkylated imino sugar, is a synthetic analogue of D-glucose."
|
| DB09134,The contrast enhancement obtained with ioversol is related to iodine content.
|
| DB01249,"Iodixanol is a contrast agent commonly used during coronary angiography,"
|
| DB00271,"Diatrizoate is the most commonly used water-soluble, iodinated, radiopaque x-ray contrast medium."
|
| DB00914,"Used to treat diabetes,"
|
| DB01295,Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension
|
| DB01297,Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias.
|
| DB01590,"Everolimus is a derivative of Rapamycin (sirolimus),"
|
| DB00987,Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia
|
| DB00305,"Mitomycin is one of the older chemotherapy drugs, which has been around and in use for decades."
|
| DB00120,Used by the brain to produce Norepinephrine
|
| DB00480,"In hematological malignancies, the immune system is deregulated in the form of altered cytokine networks in the tumour microenvironment,"
|
| DB00552,Pentostatin is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia and hairy cell leukemia
|
| DB01280,Nelarabine is a prodrug of the cytotoxic deoxyguanosine analogue 9-ß
|
| DB00724,Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist
|
| DB00970,"Generally, the actinomycins exert an inhibitory effect on gram-positive and gram-negative bacteria and on some fungi."
|
| DB05260,"Gallium nitrate exerts hypocalcemic effect by inhibiting calcium resorption from bone, possibly by stabilizing bone matrix,"
|
| DB09117,Paraldehyde blocks neuromuscular transmission
|
| DB00953,Rizatriptan is a selective agonist of serotonin (5-hydroxytryptamine
|
| DB00216,Eletriptan is a selective 5-hydroxytryptamine 1B/1D receptor agonist.
|
| DB00743,Gadobenate dimeglumine shares the pharmacokinetic properties of the ECF contrast agent gadopentetate dimeglumine
|
| DB06698,"Through its actions on the histamine receptors,"
|
| DB01489,"Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam."
|
| DB01068,"The pharmacodynamic properties of clonazepam are common among benzodiazepines and include anticonvulsive, sedative,"
|
| DB00441,Gemcitabine is a nucleoside analog that mediates its antitumour effects by promoting apoptosis of malignant cells undergoing DNA synthesis.
|
| DB00928,Azacitidine is believed to exert its antineoplastic effects by causing hypomethylation of DNA and direct cytotoxicity on abnormal hematopoietic cells in the bone marrow
|
| DB00444,"Teniposide is a phase-specific cytotoxic drug,"
|
| DB01262,"Decitabine is a prodrug analogue of the natural nucleotide 2’-deoxycytidine, which, upon being phosphorylated intracellularly,"
|
| DB00488,Altretamine is a novel antineoplastic agent.
|
| DB01117,Atovaquone is a highly lipophilic drug that closely resembles the structure .
|
| DB00664,Sulfametopyrazine is a sulfonamide antibiotic.
|
| DB00746,"Deferoxamine, otherwise known as desferrioxamine or desferal,"
|
| DB01184,Domperidone is a specific blocker of dopamine receptors.
|
| DB09071,Tasimelteon is a selective dual melatonin receptor agonist indicated for the treatment of Non-24-Hour Sleep-Wake Disorder (N24HSWD).
|
| DB11586,Studies in vitro demonstrated a significant antiviral activity in HCV replicon cell systems with an EC50 of 4nm and 1nm against the HCV genotype 1a and 1b respectively
|
| DB01181,Ifosfamide requires activation by microsomal liver enzymes to active metabolites in order to exert its cytotoxic effects
|
| DB01394,Colchicine reduces the pain resulting from gout and reduces flares of Familial Mediterranean fever by interfering with inflammatory pathways.
|
| DB00990,Aromatase is an enzyme that converts hormones to estrogen in the body's adrenal glands
|
| DB00357,"Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens,"
|
| DB09274,"Artesunate is an artemisinin derivative that is metabolized to DHA,"
|
| DB09078,Based on x-ray crystallography and kinetic interaction studies
|
| DB01299,Sulfadoxine helps inhibit the enzyme dihydropteroate synthetase which is an enzyme necessary in the conversion of PABA to folic acid.
|
| DB09231,Benidipine reduces systolic and diastolic blood pressure as well as to present decreases in heart rate pulse after treatment
|
| DB06145,The absolute bioavailability of oral spiramycin is generally within the range of 30 to 40%.
|
| DB01070,"Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol,"
|
| DB00153,"After the activation of the vitamin D receptor,"
|
| DB11156,"It has similar properties to both competitive and depolarizing neuromuscular blocking agents,"
|
| DB00550,Propylthiouracil is a thiourea antithyroid agent.
|
| DB01135,"Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant."
|
| DB00910,Secondary hyperparathyroidism is characterized by an elevation in parathyroid hormone (PTH) associated with inadequate levels of active vitamin D hormone
|
| DB00773,Etoposide is an antineoplastic agent and an epipodophyllotoxin (a semisynthetic derivative of the podophyllotoxins).
|
| DB00541,"Vincristine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma,"
|
| DB00836,Loperamide is an anti-diarrheal agent that provides symptomatic relief of diarrhea.
|
| DB08874,"Fidaxomicin has a narrow-spectrum antibacterial profile, with potent bactericidal activity specifically against C."
|
| DB06616,Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML).
|
| DB00027,Gramicidin is particularly effective against gram-positive bacteria.
|
| DB01011,Metopirone is an inhibitor of endogenous adrenal corticosteroid synthesis
|
| DB00481,Raloxifene belongs to the selective estrogen receptor modulator (SERM) drug class that exhibits estrogenic effects on bone and lipid metabolism while mediating anti-estrogenic effects on uterine endometrium and breast tissues
|
| DB01369,"Quinupristin is a streptogramin antibiotic, derived from pristinamycin I."
|
| DB00518,Albendazole is a broad-spectrum anthelmintic.
|
| DB05294,Mean IC50 of approximately 2.
|
| DB00845,Clofazimine exerts a slow bactericidal effect on <i>Mycobacterium leprae</i> (Hansen's bacillus) due primarily to its action on the bacterial outer membrane
|
| DB01051,Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete <i>Streptomyces niveus</i>.
|
| DB08806,Roxatidine acetate suppresses the effect of histamine on the parietal cells of the stomach (H2-receptor antagonist).
|
| DB12001,"In combination with fulvestrant, the progression-free survival for patients with HR-positive, HER2-negative breast cancer was 16."
|
| DB09462,Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects
|
| DB01204,"Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa,"
|
| DB02659,A major primary bile acid produced in the liver and usually conjugated with glycine or taurine.
|
| DB01183,Naloxone is an opioid receptor antagonist indicated in the reversal of opioid overdoses.
|
| DB00504,"Levallorphan, an opioid antagonist similar to naloxone, is used to treat drug overdoses."
|
| DB12070,Letermovir inhibits the activity of the DNA terminase complex of CMV thereby preventing the cutting of viral DNA into mature length genomes for packaging into viral particles
|
| DB13878,Pibrentasvir is a pan-genotypic .
|
| DB01190,Clindamycin exerts its bacteriostatic effect via inhibition of microbial protein synthesis.
|
| DB01093,"Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities."
|
| DB09055,Acipimox is a niacin derivative used as a hypolipidemic agent.
|
| DB06774,Capsaicin is a TRPV1 receptor agonist.
|
| DB00973,"Ezetimibe was shown to reduce the levels of total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apoprotein B (Apo B), non-high-density lipoprotein cholesterol (non-HDL-C),"
|
| DB01138,Sulfinpyrazone's pharmacologic activity is the potentiation of the urinary excretion of uric acid
|
| DB08811,"Like other benzodiazepines, tofisopam possesses anxiolytic properties but unlike other benzodiazepines it does not have anticonvulsant, sedative, skeletal muscle relaxant,"
|
| DB01071,In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils.
|
| DB01217,Anastrozole prevents the conversion of adrenal androgens (e.
|
| DB00882,"Clomifene (previously clomiphene) is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM)."
|
| DB01301,A pyrrolidinylmethyl tetracycline.
|
| DB00900,Didanosine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB01273,"Varenicline is a partial nicotinic acetylcholine receptor agonist,"
|
| DB08930,HIV-1 infected subjects on dolutegravir monotherapy demonstrated rapid and dose-dependent reduction of antiviral activity with declines of HIV-1 RNA copies per ml
|
| DB00778,"Roxithromycin has the following antibacterial spectrum <i>in vitro</i>: <i>Streptococcus agalactiae</i>, <i>Streptococcus pneumoniae</i> (Pneumococcus), <i>Neisseria meningitides</i> (Meningococcus), <i>Listeria monocytogenes</i>, <i>Mycoplasma pneumoniae</i>, <i>Chlamydia trachomatis</i>, <i>Ureaplasma urealyticum</i>, <i>Legionella pneumophila</i>, <i>Helicobacter</i> (Campylobacter),"
|
| DB00585,"Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells."
|
| DB11633,"Isavucoanzole exhibits antifungal activity against most strains of _Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger_,"
|
| DB06817,Raltegravir is an antiretroviral drug produced by Merck & Co.
|
| DB00759,Tetracycline is a short-acting antibiotic that inhibits bacterial growth by inhibiting translation
|
| DB01085,Pilocarpine is a choline ester miotic and a positively charged quaternary ammonium compound.
|
| DB09027,Ledipasvir acts against HCV and is categorized as a direct-acting antiviral agent (DAA).
|
| DB08909,Glycerol phenylbutyrate prolongs the QTc interval
|
| DB06742,Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus.
|
| DB00719,"Azatadine is an antihistamine, related to cyproheptadine, with anti-serotonin, anticholinergic (drying), and sedative effects."
|
| DB05015,"Beleodaq is a histone deacetylase (HDAC) inhibitor that exhibits pan-HDAC inhibition and potent growth inhibitory and pro-apoptotic activities in a variety of tumor cells,"
|
| DB00665,Nilutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer.
|
| DB00360,"Tetrahydrobiopterin (BH4) is used to convert several amino acids, including phenylalanine,"
|
| DB09343,"Tipiracil prevents trifluridine conversion into 5-trifluoromethyl-2,4(1H,3H)-pyrimidinedione, which is an inactive major metabolite, by inhibiting the enzyme thymidine phosphorylase."
|
| DB06480,"In animal studies,"
|
| DB00577,"**Antiviral effects**Valacyclovir shows varying levels of inhibition towards herpes simplex virus types 1 (HSV-1), 2 (HSV-2), Varicella Zoster Virus (VZV), Epstein-Barr virus (EBV),"
|
| DB01586,Ursodiol (commonly known as ursodeoxycholic acid) is a product of metabolism of bacteria in the intestine.
|
| DB00158,"Folic acid is a water-soluble B-complex vitamin found in foods such as liver, kidney, yeast, and leafy, green vegetables."
|
| DB01345,"Potassium is the major cation (positive ion) inside animal cells,"
|
| DB09321,"Zinc oxide has astringent, soothing and protective properties and is used in topical preparations for eczema, slight excoriations,"
|
| DB00459,Acitretin is a retinoid.
|
| DB00523,Alitretinoin (9-<i>cis</i>-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma
|
| DB08867,"Ulipristal is a selective, reversible progestin receptor modulator and its tissue targets include the uterus, cervix, ovaries,"
|
| DB06410,"Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring,"
|
| DB00302,Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin.
|
| DB09210,"Piracetam is known to mediate various pharmacodynamic actions:**Neuronal effects**: Piracetam modulates the cholinergic, serotonergic,"
|
| DB09101,Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults
|
| DB01140,"Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis,"
|
| DB00456,Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally
|
| DB00609,Ethinamate is bacteriostatic against <i>M.
|
| DB01764,"Dalfopristin is a streptogramin antibiotic,"
|
| DB00634,Sulfacetamide is a sulfonamide antibiotic with bacteriostatic actions and broad-spectrum activity against most gram-positive and many gram-negative organisms.
|
| DB12924,Although the exposure response relationship for ozenoxacin after it has been applied topically has not yet been studied
|
| DB06219,The antibacterial activity of dalbavanci
|
| DB00410,"Mupirocin is reported to be active against susceptible aerobic gram-positive cocci, such as _Staphylococcus aureus_, _Staphylococcus epidermidis_,"
|
| DB00330,Ethambutol is indicated in combination with other anti-tuberculosis drugs in the treatment of pulmonary tuberculosis.
|
| DB00760,Meropenem is a broad-spectrum carbapenem antibiotic.
|
| DB00430,Cefpiramide is a cephalosporin active against <i>Pseudomonas aeruginosa</i>.
|
| DB00260,"Cycloserine, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic,"
|
| DB00535,Cefdinir is a bactericidal agent that treats bacterial infections by interfering with cell wall synthesis.
|
| DB00828,"Although used primarily to treat urinary tract infections,"
|
| DB09047,Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus
|
| DB00162,Vitamin A is effective for the treatment of Vitamin A deficiency
|
| DB06706,Isometheptene Mucate is an indirect-acting sympathomimetic.
|
| DB06795,Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns.
|
| DB04854,"Febuxostat is a novel, selective xanthine oxidase/dehydrogenase inhibitor that works by decreasing serum uric acid in a dose-dependent manner."
|
| DB09257,"Gimeracil is an adjunct to antineoplastic therapy,"
|
| DB01004,Ganciclovir is a synthetic nucleoside analogue of 2'-deoxyguanosine that inhibits replication of herpes viruses both <i>in vitro</i> and <i>in vivo</i>.
|
| DB00811,Ribavirin mediates direct antiviral activity against a number of DNA and RNA viruses by increasing the mutation frequency in the genomes of several RNA viruses
|
| DB01436,"Alfacalcidol works to increase serum levels of calcium by stimulating intestinal calcium absorption, reabsorption of calcium from bone,"
|
| DB00256,"Lymecycline, like other tetracyclines, exerts bacteriostatic actions on intracellular and extracellular bacteria,"
|
| DB00495,Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB00499,Flutamide is a nonsteroidal antiandrogen.
|
| DB00666,Nafarelin is a potent agonistic analog of gonadotropin-releasing hormone (GnRH).
|
| DB11256,Levomefolic acid is an active metabolite of folic acid and a methyl group donor in one-carbon metabolism reactions.
|
| DB11596,Levoleucovorin is actively and passively transported across cell membranes.
|
| DB06274,Alvimopan is a peripherally acting μ opioid antagonist.
|
| DB09049,Use of opioids induces slowing of gastrointestinal motility and transit.
|
| DB06813,"Pralatrexate is a folate analog that inhibits folate metabolism, thus impeding the synthesis of amino acids and nucleic acid."
|
| DB00460,"Verteporfin,"
|
| DB11268,"Also known as protocatechuic aldehyde, protocatechualdehyde is a naturally-occuring phenolic aldehyde that is found in barley, green cavendish bananas, grapevine leaves and root of the herb S."
|
| DB00720,Clodronic acid is a first generation bisphosphonate that inhibits osteoclast mediated bone resorption
|
| DB00630,Alendronic acid tablets have a very low oral bioavialability.
|
| DB09138,Technetium (99mTc) medronic acid is a pharmaceutical product used in nuclear medicine imaging.
|
| DB00282,Pamidronic acid is a second generation
|
| DB01077,"Etidronic acid is a first generation bisphosphonate that inhibits the action of osteoclasts,"
|
| DB00035,By mimicking the actions of endogenous ADH
|
| DB01133,Tiludronic acid is a bisphosphonate that prevents osteoclasts from resorbing bone.
|
| DB00399,"Zoledronic acid is a third generation,"
|
| DB04865,The pharmacodynamics of homoharringtonine is not fully understood.
|
| DB01160,Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2<sub>alpha</sub>.
|
| DB00917,Dinoprostone is equivalent to prostaglandin E2 (PGE2).
|
| DB01046,Chronic idiopathic constipation is generally defined by infrequent or difficult passage of stool.
|
| DB11660,Upon applying an appropriate dose of latanoprost bunod
|
| DB08819,Tafluprost is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α
|
| DB00929,Misoprostol is a prostaglandin E1 analog used to reduce the risk of NSAID induced gastric ulcers by reducing secretion of gastric acid from parietal cells
|
| DB08964,Gemeprost softens and dilates of the cervix prior to transcervical intrauterine operative procedures
|
| DB00429,Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy
|
| DB04571,Trioxsalen ispharmacologically inactive but when exposed to ultraviolet radiation or sunlight it is converted to its active metabolite to produce a beneficial reaction affecting the diseased tissue
|
| DB00855,The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis.
|
| DB09536,"Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium."
|
| DB01878,Benzophenone is the organic compound.
|
| DB00140,"Riboflavin or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health."
|
| DB01414,Cefacetrile is effective against many Gram-positive bacterial strains and somewhat less effective against Gram-negative species.
|
| DB00229,Cefotiam is a third generation beta-lactam cephalosporin antibiotic that works by inhibiting bacterial cell wall biosynthesis
|
| DB00583,Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane
|
| DB01603,"Meticillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class."
|
| DB01327,Cefazolin (also known as cefazoline or cephazolin) is a semi-synthetic first generation cephalosporin for parenteral administration.
|
| DB01326,The parenteral prodrug formate ester cefamandole nafate is a broad-spectrum cephalosporin antibiotic.
|
| DB01331,Cefoxitin is a cephamycin antibiotic often grouped with the second-generation cephalosporins.
|
| DB06713,Norelgestromin is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring.
|
| DB09389,Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception.
|
| DB06176,Romidepsin is a selective inhibitor of histone deacetylase
|
| DB00560,Tigecycline is the first clinically-available drug in a new class of antibiotics called the glycylcyclines.
|
| DB08916,"Aberrant ErbB signaling triggered by receptor mutations, and/or amplification,"
|
| DB01191,"Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses."
|
| DB06691,"Mepyramine, or pyrilamine, targets the H1 receptor."
|
| DB06217,Vernakalant blocks currents in all phases of atrial action potential including atria-specific potassium currents (the ultra-rapid delayed rectifier and the acetylcholine dependent potassium currents) and prolongs the refractory period
|
| DB11994,Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity
|
| DB06800,Use of opioids induces slowing of gastrointestinal motility and transit.
|
| DB08869,"Tesamorelin stimulates growth hormone secretion,"
|
| DB13747,Acts as a surfactant or alkalizing agent
|
| DB11610,Oxilofrine is a sympathomimetic which increases adrenergic activity
|
| DB00411,Carbamoylcholine is a parasympathomimetic that acts as an agonist of muscarinic and nicotinic receptors
|
| DB00718,Adefovir dipivoxil a diester prodrug of adefovir.
|
| DB00369,Cidofovir is a new anti-viral drug.
|
| DB00339,Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB).
|
| DB00380,Dexrazoxane is a cardioprotective agent
|
| DB01575,Kaolin is an adsorptive agent.
|
| DB00859,Penicillamine is a chelating agent used in the treatment of Wilson's disease.
|
| DB00728,Neuromuscular blocking agents are drugs that cause skeletal muscle relaxation primarily by causing a decreased response to the neurotransmitter acetylcholine (ACh) at the myoneural (neuromuscular) junction of skeletal muscle
|
| DB13450,"Cisatracurium is a non-depolarising neuromuscular blocking agent of the benzylisoquinolinium class, available in its salt form,"
|
| DB09153,"Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance,"
|
| DB01063,Acetophenzine is a phenothiazine antipsychotic intended for the management of schizophrenia and other psychotic disorders
|
| DB09018,Bromopride is a dopamine antagonist used as an antiemetic.
|
| DB09097,Quinagolide achieves long-lasting reduction in prolactin levels in a dose-proportional effect via selectively targeting D2 receptors as an agonist
|
| DB01213,"Fomepizole is a competitive inhibitor of alcohol dehydrogenase,"
|
| DB01006,Letrozole is an aromatase inhibitor used in the treatment of breast cancer.
|
| DB00969,Alosetron is a potent and selective antagonist of the serotonin 5-HT<sub>3</sub> receptor type.
|
| DB00911,Tinidazole is a synthetic antiprotozoal agent.
|
| DB04845,Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug.
|
| DB11574,"Elbasvir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotypes 1a, 1b,"
|
| DB08932,Macitentan acts primarily by reducing vasoconstriction and cell proliferation due to endothelin overexpression
|
| DB01256,Retapamulin is a semisynthetic pleuromutilin antibiotic.
|
| DB09555,"In allergic reactions,"
|
| DB11817,Baricitinib is a disease-modifying antirheumatic drug (DMARD) used to ameliorate symptoms and slow down the progression of rheumatoid arthritis.
|
| DB09297,At concentrations approximately 6 and 1.
|
| DB11575,"Grazoprevir is classified as a direct-acting antiviral (DAA) and prevents viral replication in HCV genotypes 1a, 1b,"
|
| DB05541,Brivaracetam binds SV2A with high affinity .
|
| DB11737,"In vitro: Icotinib inhibits EGFR activity in a dose-dependent manner, with an IC50 value of 5 nM and complete inhibition at 62."
|
| DB00136,"Calcitriol is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities."
|
| DB04930,"Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites,"
|
| DB00617,Paramethadione is an oxazolidinedione anticonvulsant similar to trimethadione that acts on the central nervous system (CNS) to reduce the number of absence seizures (often seen in epileptics)
|
| DB00347,Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications
|
| DB01105,Sibutramine is an orally administered agent for the treatment of obesity.
|
| DB11828,"Neratinib is a tyrosine kinase inhibitor which exhibits antitumor action against Epidermal Growth Factor Receptor (EGFR), HER2,"
|
| DB11614,"Rupatadine is an anti allergenic and acts to reduce allergic symptoms like urticaria, rhinorrhea,"
|
| DB01216,Finasteride is an antiandrogenic compound that works by suppressing the production of serum and intraprostatic dihydrotestosterone (DHT) in men via inhibiting the enzyme responsible for the biosynthesis of DHT
|
| DB00947,Fulvestrant for intramuscular administration is an estrogen receptor antagonist without known agonist effects
|
| DB00943,Zalcitabine is an analog of 2'-deoxycytidine that is pharmacologically related to but structurally different from other nucleotide reverse transcriptase inhibitors (NRTIs)
|
| DB11581,"Venetoclax induces rapid and potent onset apoptosis of CLL cells, powerful enough to act within 24h and to lead to tumor lysis syndrome , ,"
|
| DB00426,Famciclovir is a prodrug that undergoes rapid biotransformation to the active antiviral compound penciclovir
|
| DB01179,"Podofilox, also called podophyllotoxin,"
|
| DB00185,Cevimeline is a cholinergic agonist which binds to muscarinic receptors.
|
| DB06777,"It acts by reducing levels of cholesterol in the bile,"
|
| DB11915,Valbenazine decreases the availability of monoamine neurotransmitters by preventing their storage in synaptic vesicles
|
| DB12483,Copanlisib has demonstrated potent anti-tumor and pro-apoptotic activity in various tumor cell lines and xenograft models .
|
| DB00853,Temozolomide is a prodrug of the imidazotetrazine class that requires nonenzymatic hydrolysis at physiological pH _in vivo_ to perform alkylation of adenine/guanine residues
|
| DB01423,The drug promotes drainage of mucus from
|
| DB00352,Thioguanine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia
|
| DB01073,Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia.
|
| DB00262,Carmustine is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors
|
| DB08908,The physiological effects of dimethyl fumarate on the body are not well understood.
|
| DB00242,Cladribine is a synthetic purine nucleoside that acts as an antineoplastic agent with immunosuppressive effects
|
| DB11989,"Benznidazole is a trypanocidal agent which kills the causative organism in Chagas disease,"
|
| DB00291,Chlorambucil is an antineoplastic in the class of alkylating agents that is used to treat various forms of cancer
|
| DB00290,Bleomycin is an antibiotic which has been shown to have antitumor activity.
|
| DB00851,Dacarbazine is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC).
|
| DB08798,Sulfamoxole is a sulfonamide antibiotic.
|
| DB01298,Sulfacytine is a short-acting sulfonamide.
|
| DB01581,"Sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthetase (DHPS),"
|
| DB00562,Benzthiazide is used to treat hypertension and edema.
|
| DB00576,Sulfamethizole is a sulfonamide antibiotic.
|
| DB08796,Antitussive agents act centrally on the medullary cough center
|
| DB01284,Cosyntropin exhibits the full corticosteroidogenic activity of natural ACTH
|
| DB00190,"When mixed with ,"
|
| DB06766,"Following bilateral topical ocular administration of alcaftadine ophthalmic solution, 0."
|
| DB08967,Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions
|
| DB00354,Buclizine is a piperazine-derivative antihistamine used as an antivertigo/antiemetic agent.
|
| DB08802,"Isothipendyl, an azaphenothiazine derivative, competitively binds to histamine (H1) receptors, resulting in inhibition of the pharmacological effects of histamines."
|
| DB01620,"Pheniramine acts as an antagonist to allergic symptoms stemming from inappropriate histamine release to reduce edema, itching,"
|
| DB08800,Chlorpyramine is a competitive reversible H1 receptor antagonist.
|
| DB00885,Pemirolast is used for the prophylactic treatment of itching of the eye associated with allergic conjunctivitis
|
| DB08801,Dimethindene occurs as a racemic mixture.
|
| DB01619,Phenindamine is an antihistamine.
|
| DB00978,"Lomefloxacin is a fluoroquinolone antibiotic used to treat chronic bronchitis,"
|
| DB00787,Acyclovir is a nucleoside analog that inhibits the action of viral DNA polymerase and DNA replication of different herpesvirus
|
| DB05990,"The activation of the FXR by obeticholic acid acts to reduce the synthesis of bile acids, inflammation,"
|
| DB00303,Ertapenem is a carbapenem antibiotic drug that is marketed under the trade name Invanz by Merck & Co.
|
| DB01598,Imipenem is a beta-lactam antibiotic belongings to the subgroup of carbapenems
|
| DB06211,Similar to other beta-lactam antimicrobial agents
|
| DB01089,"Deserpidine, an alkaloid of <i>Rauwolfia canescens</i>, is used as an antihypertensive."
|
| DB01613,Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin
|
| DB06403,Ambrisentan 10 mg daily had no significant effect on the QTc interval
|
| DB11943,Delafloxacin is a fluoroquinolone antibacterial drug which kills bacterial cells
|
| DB09135,As with other iodinated contrast agents the degree of contrast enhancement is directly related to the iodine content in the administered dose
|
| DB04711,"Following intravenous administration of Cholografin Meglumine,"
|
| DB01362,"Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography,"
|
| DB09156,"Iopromide is a low osmolar,"
|
| DB08947,"Iopamidol is a contrast agent developed by Bracco with nonionic,"
|
| DB00642,"Pemetrexed inhibited the in vitro growth of mesothelioma cell lines (MSTO-211H, NCI-H2052) and showed synergisticeffects when combined with cisplatin."
|
| DB06769,No mean changes in QTc interval greater than 20 milliseconds were detected up to one hour post-infusion
|
| DB08889,Intravenous carfilzomib administration resulted in suppression of proteasome chymotrypsin-like activity when measured in blood 1 hour after the first dose.
|
| DB00293,Raltitrexed belongs to a group of medicines known as antimetabolites.
|
| DB08828,Vismodegib selectively binds to and inhibits the transmembrane protein Smoothened homologue (SMO) to inhibit the Hedgehog signalling pathway
|
| DB01094,Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices.
|
| DB09272,"Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D)."
|
| DB00134,L-Methionine is a principle supplier of sulfur which prevents disorders of the hair
|
| DB00832,Phensuximide suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in absence (petit mal) seizures
|
| DB00730,Thiabendazole is a fungicide and parasiticide.
|
| DB01610,Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.
|
| DB01438,Phenazopyridine acts as a local anesthetic offering relief from irritating conditions of the urinary tract.
|
| DB06782,"Due to its oily nature,"
|
| DB00769,Hydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses
|
| DB06202,"Lasofoxifene exhibits both significant estrogenic and antiestrogenic activity both in vitro and in vivo, targeting any tissues that possess ERs, such as bone, uterus, breast, blood vessels,"
|
| DB06401,"Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals."
|
| DB09096,Benzoyl peroxide is a topical treatment for acne that generates free radicals to break down comedones and increase the rate of epithelial cell turnover
|
| DB08934,Sofosbuvir acts against HCV and is categorized as a direct-acting antiviral agent (DAA).
|
| DB01412,"Theobromine, a xanthine derivative like caffeine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic,"
|
| DB11106,"Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline."
|
| DB09338,Mersalyl acid is an organomercuric compound.
|
| DB01294,"Bismuth subsalicylate is an antacid and antimicrobial, gastroprotective, anti-secretory, and anti-inflammatory actions."
|
| DB00152,"Thiamine is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities."
|
| DB11135,Selenium is incorporated into many different selenoproteins which serve various functions throughout the body
|
| DB09322,"Zinc has been identified as a cofactor for over 70 different enzymes, including alkaline phosphatase, lactic dehydrogenase and both RNA and DNA polymerase."
|
| DB11239,"Aluminum sulfate may be used as a deodorant, as well as an astringent ."
|
| DB11342,Aluminum oxide has a chemical formula Al2O3.
|
| DB11136,"Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions."
|
| DB00355,Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from <i>Chromobacterium violaceum</i>
|
| DB06827,Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin
|
| DB06771,Besifloxacin tear concentrations were higher than MIC90 (minimum inhibitory concentration) values for common bacterial pathogens and sustained for 24 hours or longer.
|
| DB08965,"Fusafungine is an antibiotic from Fusarium lateririum,"
|
| DB00954,Dirithromycin is a pro-drug which is converted non-enzymatically during intestinal absorption into the microbiologically active moiety erythromycylamine
|
| DB01415,Ceftibuten is an antibiotic with bactericidal actions
|
| DB00803,Colistin is a polymyxin antibiotic agent.
|
| DB00626,Bacitracin is a mixture of polypeptides that prevent the formation of the bacterial cell wall and oxidatively cleave DNA
|
| DB09499,"Sodium thiosulfate doses of 20, 15 and 10 g/m deliver sodium loads of 162, 121 and 81 mmol/m."
|
| DB01150,"Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections,"
|
| DB00080,Daptomycin is a cyclic lipopeptide antibacterial agent produced as a fermentation product by the soil microbe _Streptomyces roseosporus_.
|
| DB00595,Oxytetracycline is known as a broad-spectrum antibiotic due to its activity against such a wide range of infections.
|
| DB04570,Latamoxef works by inhibiting bacterial cell wall biosynthesis
|
| DB09060,Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz).
|
| DB00649,Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB00709,Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV) to disrupt viral DNA synthesis.
|
| DB00122,This compound is needed for good nerve conduction throughout the CNS (central nervous system) as it is a precursor to acetylcholine (ACh).
|
| DB00931,Methacycline is a tetracycline antibiotic.
|
| DB00453,Clomocycline is a tetracycline antibiotic that is commonly prescribed by medical doctors for infections and to treat acne.
|
| DB11641,The antitumour effects of vinflunine are dependent on concentration and exposure duration of the drug
|
| DB11691,Naldemedine is an opioid receptor antagonist with restricted movement across the blood brain barrier
|
| DB02300,Calcipotriene is a synthetic analog of vitamin D.
|
| DB00130,"Like other amino acids, glutamine is biochemically important as a constituent of proteins."
|
| DB09130,Copper is incorporated into many enzymes throughout the body as an essential part of their function .
|
| DB09290,"Ramosetron is a _serotonin 5-HT3 receptor antagonist_ commonly employed to treat nausea and vomiting,"
|
| DB00761,The potassium ion is in the principle intracellular cation of most body tissues.
|
| DB01121,"Phenacemide is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures,"
|
| DB00740,"Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS)."
|
| DB06218,Lacosamide therapy is correlated with a decrease in seizure frequency.
|
| DB04339,"Due to its mucolytic effects, carbocisteine significantly reduces sputum viscosity, cough, dyspnea and fatigue."
|
| DB00561,Doxapram is an analeptic agent (a stimulant of the central nervous system)
|
| DB06709,"Methacholine is a non-specific cholinergic agonist (parasympathomimetic) that acts through muscarinic receptors in the lungs to induce bronchoconstriction, which is more significant in patients with asthma than those without."
|
| DB01019,Bethanechol is selective for muscarinic receptors and has little to no impact on nicotinic receptors
|
| DB03128,A neurotransmitter.
|
| DB01228,"Used to treat irregular heartbeats, encainide decreases excitability, conduction velocity, and automaticity as a result of slowed atrial, atrioventricular (AV) nodal, His-Purkinje,"
|
| DB01107,"Methyprylon, a piperidinedione CNS depressant, is close to barbituric acid in structure, but different enough to be called a ""non-barbiturate"" sedative-hynotic."
|
| DB01429,Aprindine is a cardiac depressant used in arrhythmias
|
| DB00336,Nitrofurazone is a topical antibacterial agent indicated as an adjunctive therapy for second and third degree burns when resistance to other agents is a real or potential problem
|
| DB08824,iodine-123 labeled ioflupanebinds selectively to striatal presynaptic dopamine neurons by binding reversibly to presynaptic dopamine transporters
|
| DB09273,Doxofylline is a methylxanthine bronchodilator with potent bronchodilator activity comparable to that of theophylline.
|
| DB06704,AdreView is a diagnostic radiopharmaceutical which contains a small quantity of iobenguane that is not expected to produce a pharmacodynamic effect
|
| DB06794,Lodoxamide is a mast cell stabilizer that inhibits the in vivo Type 1 immediate hypersensitivity reaction
|
| DB01084,Emedastine is a relatively selective H<sub>1</sub>-receptor antagonist
|
| DB00920,Ketotifen is a non-competitive histamine antagonist and mast cell stabilizer.
|
| DB00847,Cystine accumulation is the cause of organ damage in cystinosis.
|
| DB01066,"Cefditoren pivoxil is a prodrug which is hydrolyzed by esterases during absorption,"
|
| DB06626,Axitinib prevents the progression of cancer by inhibiting angiogenesis and blocking tumor growth
|
| DB09079,Nintedanib is a small molecule kinase inhibitor that inhibits upstream kinase activity to ultimately inhibit lung fibroblast proliferation and migration
|
| DB06637,Dalfampridine is a board-spectrum lipophillic potassium channel blocker and binds favourably to the open state than closed state of the potassium channel in the CNS
|
| DB09414,Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues
|
| DB09561,Glycerophosphate acts as a source of inorganic phosphate through hydrolysis
|
| DB09020,"Patients should be counselled regarding abdominal pain, nausea, vomiting, or a change in bowel function that lasts longer than 2 weeks."
|
| DB08826,Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs
|
| DB09268,"Sodium picosulfate is a stimulant laxative that in conjunction with magnesium citrate, produces a purgative effect on stools."
|
| DB00471,Montelukast is a leukotriene receptor antagonist that demonstrates a marked affinity and selectivity to the cysteinyl leukotriene receptor type-1 in preference to many other crucial airway receptors like the prostanoid
|
| DB01126,"Dutasteride is a synthetic 4-azasteroid compound that selectively inhibits both the type I and type II isoforms of steroid 5α-reductase,"
|
| DB06155,"In the RIO-North America trial,"
|
| DB09262,Imidafenacin is an antimuscarinic agent which acts to reduce the frequency of urination in patients with overactive bladder
|
| DB09143,Sonidegib has been shown to inhibit a transmembrane protein called SMO which plays a role in Hh signal transduction
|
| DB08875,"Cabozantinib suppresses metastasis, angiogenesis,"
|
| DB09061,"Although the exact mechanism and magnitude of effects of THC and CBD are not fully understood, CBD has been shown to have analgesic, anticonvulsant, muscle relaxant, anxiolytic, neuroprotective,"
|
| DB05239,Cobimetinib is a reversible inhibitor of mitogen-activated protein kinase 1 (MAPK)/extracellular signal-regulated kinase 1 (MEK1) and MEK2
|
| DB00799,"Following topical application, tazarotene undergoes esterase hydrolysis to form its active metabolite, tazarotenic acid."
|
| DB03756,DHA in the central nervous system is found in the phospholipid bilayers where it modulates the physical environment and increase the free volume within the membrane bilayer
|
| DB11560,Dose-dependent reductions in serum uric acid levels and increases in urinary uric acid excretion have been observed following single and multiple oral doses of lesinurad
|
| DB06803,Niclosamide is an antihelminth used against tapeworm infections.
|
| DB00640,Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy and also indicated for conversion of sinus rhythm of paroxysmal supraventricular tachycardia
|
| DB06264,"Tolperisone is an oral, centrally acting muscle relaxant."
|
| DB01303,Oxtriphylline is a bronchodilator.
|
| DB13146,"Following intravenous administration, the tumor-to-normal tissue contrast is highest between 2 and 10 minutes after injection,"
|
| DB09161,Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging
|
| DB09293,The therapeutic effects of sodium iodide I-131 are a result of the ionizing radiation absorbed by the thyroidal tissue
|
| DB01411,Pranlukast is a cysteinyl leukotriene receptor-1 antagonist
|
| DB01048,Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1).
|
| DB08957,Hexoprenaline is a stimulant of beta 2 adrenergic receptors.
|
| DB03619,"Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine,"
|
| DB05528,"Mipomersen sodium decreases the levels of apolipoprotein B (apo B), low density lipoprotein (LDL) non-high density lipoprotein-cholesterol,"
|
| DB06213,Regadenoson rapidly increases coronary blood flow (CBF) which is sustained for a short duration
|
| DB09269,Phenylacetic acid is an organic compound containing a phenyl functional group and a carboxylic acid functional group.
|
| DB09067,"In normal subjects, intravenous administration of corticorelin results in a rapid and sustained increase of plasma ACTH levels and a near parallel increase of plasma cortisol."
|
| DB00115,"**General effects**Cyanocobalamin corrects vitamin B12 deficiency and improves the symptoms and laboratory abnormalities associated with pernicious anemia (megaloblastic indices, gastrointestinal lesions, and neurologic damage)."
|
| DB06689,"When injected intravenously,"
|
| DB13153,"Levomenol is an anti-inflammatory and natural moisturizing agent that has been found to diminish the signs of photodamage, reduce pruritus,"
|
| DB08884,"Gadoxetate disodium is an amphipathic compound in which gadoxetate is hydrophillic and its moiety, the ethoxybenyzl group, is lipophillic."
|
| DB04967,"Although lucanthone has structural and biochemical similarities to Actinomycin D, it has no hematological or gastro-intestinal toxicity at clinically tolerated doses."
|
| DB06816,Pyrvinium is an anthelmintic agent which acts to kill pinworms
|
| DB11121,Chloroxylenol is a substituted phenol which has been widely used for many years as an ingredient of antiseptic and disinfectant products intended for external use
|
| DB04786,A polyanionic compound with an unknown mechanism of action
|
| DB00711,Diethylcarbamazine is an anthelmintic drug that does not resemble other antiparasitic compounds
|
| DB08974,Flubendazole is an anthelmintic that is used to treat worm infection in humans.
|
| DB05630,The mode of action of sodium stibogluconate is not clearly understood
|
| DB11254,"Hexylresorcinol is a phenol derivative,"
|
| DB09277,Choline is phosphorylated by choline kinase into phosphorylcholine.
|
| DB09125,Potassium citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.
|
| DB09015,Canrenoic acid (as the salt potassium canrenoate) is an aldosterone antagonist.
|
| DB13925,The overexpression of somatostatin recep
|
| DB00236,Pipobroman is an antineoplastic agent.
|
| DB09094,"Cell division is arrested and other cellular processes are impaired,"
|
| DB00432,"Trifluridine exhibits an antiviral effect against herpes simplex virus,"
|
| DB06193,"Pixantrone has a wide range of antitumor activity, especially in terms of treating leukemias and lymphomas ."
|
| DB11793,Niraparib mediated cytotoxic effects in tumour cell lines with or without deficiencies in _BRCA1/2_
|
| DB00548,"Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley."
|
| DB00894,Testolactone is a synthetic anti-neoplastic agent that is structurally distinct from the androgen steroid nucleus in possessing a six-membered lactone ring in place of the usual five-membered carbocyclic D-ring
|
| DB00791,Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA).
|
| DB06243,Eflornithine is a prescription drug indicated in the treatment of facial hirsutism (excessive hair growth)
|
| DB11231,"Lycopene is a naturally occuring red carotenoid pigment that is responsible in red to pink colors seen in tomatoes, pink grapefruit,"
|
| DB01108,Trilostane blocks an enzyme involved in the production of several steroids including cortisol.
|
| DB08913,"Physiologically, Radium Ra 223 Dichloride,"
|
| DB00992,"After topical application of methyl aminolevulinate, porphyrins will accumulate intracellularly in the treated skin lesions."
|
| DB09516,Mequinol is in fact considered a melanocytotoxic chemical which when oxidized in melanocytes results in the formation of toxic entities like quinones
|
| DB01579,"Phendimetrazine is a phenylalkylamine sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity,"
|
| DB09069,Trimetazidine is indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies
|
| DB09276,"Unknown,"
|
| DB00513,Aminocaproic acid works as an antifibrinolytic.
|
| DB09185,Viloxazine is a serotonin-norepinephrine modulating agent that has been used as a treatment for depression and Attention Deficit Hyperactivity Disorder (ADHD).
|
| DB02959,The psychoactive action of 5-HTP is thought to be due to increased serotonin production in central nervous system tissue
|
| DB09021,Benzoctamine acts as a sedative and axiolytic agent
|
| DB05245,Silver sulfadiazine has broad antimicrobial activity.
|
| DB06150,"Sulfadimethoxine has been shown to be effective against streptococci, klebsiella, proteus, shigella, staphylococci, escherichia,"
|
| DB00442,Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV).
|
| DB00879,"Emtricitabine is a cytidine analog that competes with the natural substrate of HIV-1 reverse transcriptase to be incorporated into newly formed DNA,"
|
| DB00581,Lactulose formulations are most commonly administered via the oral route or the rectal route.
|
| DB01582,Sulfamethazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase).
|
| DB00891,Sulfapyridine is a sulfonamide antibiotic.
|
| DB04398,Lactic acid produces a metabolic alkalinizing effect
|
| DB09221,Used to treat/manage peptic ulcer disease or irritation of the gastrointestinal tract by promoting tissue healing by the elimination of free radicals
|
| DB01378,"Magnesium hydroxide is used primarily in ""Milk of Magnesia"", a white aqueous,"
|
| DB09087,"The presence of potassium alum reduces swollen mucous membranes that result from inflammation of the nasal,"
|
| DB01413,Cefepime is a fourth-generation cephalosporin antibiotic.
|
| DB00766,"Clavulanic acid inactivates some beta-lactamase enzymes that are produced by bacteria,"
|
| DB08993,Cyclic basic peptide related to viomycin.
|
| DB09154,Citrate prevents activation of the clotting cascade by chelating calcium ions.
|
| DB00837,"Progabide, a fatty acid derivative,"
|
| DB09137,Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to a technetium-99m ion.
|
| DB00662,Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans.
|
| DB08996,Little is known about the pharmacology of dimetacrine
|
| DB00198,"There have been postmarketing reports of delirium and abnormal behavior leading to injury, and in some cases resulting in fatal outcomes,"
|
| DB06804,Nonoxynol-9 (N-9) is a typical surfactant used as a vaginal spermicide.
|
| DB01599,Probucol lowers cholesterol levels by increasing LDL (low-density lipoprotein) breakdown.
|
| DB00551,"Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea."
|
| DB01553,"Cloxazolam, administered as a single oral dose of 3mg, when compared to a single 5 mg dose of diazepam in one study,"
|
| DB09014,"Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic."
|
| ,
|
|
|
