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|---|---|---|---|---|---|---|---|---|---|
48487c6a4d7ddfc4face3610b25c6eda | mteb/scifact | Ribosomal protein (RP) expression is controlled in part by stress-activated regulators. | Pathway connectivity and signaling coordination in the yeast stress-activated signaling network. Stressed cells coordinate a multi-faceted response spanning many levels of physiology. Yet knowledge of the complete stress-activated regulatory network as well as design principles for signal integration remains incomplete... | [
"Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 dir... | 1046 | 418246 | [
"17055665",
"16527698",
"4795303",
"1605392"
] | scientific_claim_retrieval | scientific |
e0525aacdff867f17a217c3d4adfc28c | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Fundamental difference between superblockers and superspreaders in networks. Two important problems regarding spreading phenomena in complex topologies are the optimal selection of node sets either to minimize or maximize the extent of outbreaks. Both problems are nontrivial when a small fraction of the nodes in the ne... | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | mr4v0hkn | [
"xe0xey1n",
"1u44tdrj",
"rjyu8lfl",
"acidfmjc"
] | biomedical_literature_retrieval | scientific |
30e168480ae175410056e7be2b1c6526 | mteb/scifact | Birth-weight is negatively associated with breast cancer. | Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies. BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual participant d... | [
"Birth weight and mammographic density among postmenopausal women in Sweden.. Birth weight is a significant predictor of breast cancer risk in adult life and mammary gland mass could be an intermediate stage in this long process. We have studied the association of birth size measurements with mammographic density, ... | 178 | 16322674 | [
"5487448",
"16701509",
"13765757",
"25973484"
] | scientific_claim_retrieval | scientific |
eb6b1e3eff6c21e90f11ffb82c5b516a | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | School closures during the 2009 influenza pandemic: national and local experiences. BACKGROUND: School closure is a non-pharmaceutical intervention that was considered in many national pandemic plans developed prior to the start of the influenza A(H1N1)pdm09 pandemic, and received considerable attention during the even... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | 3amxb7qr | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
2fa76d8cd8a4bd186401a09fa8ec5233 | mteb/trec-covid | what type of hand sanitizer is needed to destroy Covid-19? | Disinfection, Sterilization, and Control of Hospital Waste | [
"Airspace-Occupying Diseases. Diseases of the air space of the lung share many common findings and presentation that it makes more sense to be grouped together in a differential diagnosis. The common imaging finding is usually as a lung infiltrate or consolidation of some type of distribution or another. Trying to ... | 19 | 2cv9tr7t | [
"1ses23oz",
"vmcy38wt",
"mmd8ru3r",
"aet9nitv"
] | biomedical_literature_retrieval | scientific |
564ccf4337a4cfab00ea0a8246424fe7 | mteb/scifact | qSOFA scores are associated with length of stay in emergency department patients. | Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit. Importance The Sepsis-3 Criteria emphasized the value of a change of 2 or more points in the Sequential [Sepsis-related] Organ Failure Assessment (SO... | [
"Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus.. CONTEXT Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with ... | 1401 | 5185871 | [
"13282296",
"27054878",
"14021596",
"26611094"
] | scientific_claim_retrieval | scientific |
a40b5e0d4c10cc493b71ebfa1accf1e1 | mteb/scifact | Taking 400mg of α-tocopheryl acetate in combination with vitamin C reduces the risk of prostate cancer. | Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial.. CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements. A large-scale ra... | [
"Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study. BACKGROUND There is overwhelming evidence that behavioural factors influence health, but their combined impact on the general population is less well documented. We aimed to quantify the potential co... | 1141 | 12009265 | [
"12794099",
"25589047",
"24581365",
"4828631"
] | scientific_claim_retrieval | scientific |
94867733607ed31cfb8d3d722b804589 | mteb/trec-covid | what kinds of complications related to COVID-19 are associated with hypertension? | Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. The potential for avian influenza H5N1 outbreaks has increased in recent years. Thus, it is paramount to develop novel strategies to alleviate death rates. Here we show that avian influenza A H5N1-infected patients exhibit markedly ... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 23 | 57q69icp | [
"beqvgdjo",
"694a1jef",
"cnygzwkw",
"ucthbqvt"
] | biomedical_literature_retrieval | scientific |
3e84346e634a59a5398d79388d5d06a5 | mteb/scifact | Trans-acting factors, such as lncRNAs, influence mRNA translation. | LincRNA-p21 suppresses target mRNA translation.. Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitme... | [
"Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain.. Treatment with second-generation antipsychotic agents such as olanzapine frequently results in metabolic adverse effects, e.g. hyperphagia, weight gain and dyslipidaemia in patients of both genders. The molec... | 1311 | 13763195 | [
"45153864",
"7029990",
"86129154",
"26378103"
] | scientific_claim_retrieval | scientific |
1334c91f730f41317d607e412f28dce1 | mteb/scifact | ER-localized phosphatase Sac1 processes PI4P through coordination with OSBP and the endosome-localized protein sorting nexin 2. | Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-anchored protein that helps generate tethers between the ER and other membranes through which lipids are exchanged across adjacent b... | [
"Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum.. The integrin family of heterodimeric cell-surface receptors are fundamental in cell-cell and cell-matrix adhesion. Changes to either integrin-ligand affinity or integrin gene expression are central to a variety o... | 365 | 600437 | [
"8453819",
"4373445",
"4411760",
"23305884"
] | scientific_claim_retrieval | scientific |
efe9402da83bf4d4089ddd9ee150600a | mteb/scifact | Pyridostatin decreases telomere fragility in BRCA2-deficient cells. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism. Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this... | 990 | 16472469 | [
"4899981",
"2758012",
"2679511",
"14446279"
] | scientific_claim_retrieval | scientific |
592e1172a5f1825dc44fa50c7bf942e3 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Lessons from the History of Quarantine, from Plague to Influenza A. In the new millennium, the centuries-old strategy of quarantine is becoming a powerful component of the public health response to emerging and reemerging infectious diseases. During the 2003 pandemic of severe acute respiratory syndrome, the use of qua... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | zxe95qy9 | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
7923641e9e8e07ff550a7baaba7e53d1 | mteb/scifact | The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions. | Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation.. Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid ce... | [
"A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells.. Neurogenesis occurs in the hippocampus of the developing and adult brain due to the presence of multipotent stem cells and restricted precursor cells at different stages of differentiation. It has been p... | 1212 | 44724517 | [
"23901235",
"43619625",
"4427060",
"25606339"
] | scientific_claim_retrieval | scientific |
6879fb5d786da81954091fa3854d606d | mteb/scifact | PKG-la does not have a large impact on expression of spinal long term potentiation in PGK-la knockout mice. | Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity. Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for ... | [
"Blood stem cells emerge from aortic endothelium by a novel type of cell transition. The ontogeny of haematopoietic stem cells (HSCs) during embryonic development is still highly debated, especially their possible lineage relationship to vascular endothelial cells. The first anatomical site from which cells with lo... | 910 | 11254556 | [
"243694",
"25789730",
"11992632",
"13368032"
] | scientific_claim_retrieval | scientific |
3789e3e8bacec9449a78ec9104779d14 | mteb/scifact | Immune responses in immune cells are geographically segregated. | Inflammatory signaling in human Tuberculosis granulomas is spatially organized. Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects w... | [
"CD28 and ITK signals regulate autoreactive T cell trafficking. Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized by lymphocytic... | 559 | 3475317 | [
"2462673",
"6123521",
"10627801",
"4928282"
] | scientific_claim_retrieval | scientific |
d5cf2a49d1b40b7c65a5fa51ed76e55e | mteb/scifact | The C-type lectin receptor (CLEC-2) rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces. | Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2. To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN). PDPN is express... | [
"Porcine circovirus type 2 DNA influences cytoskeleton rearrangements in plasmacytoid and monocyte-derived dendritic cells.. Functional disruption of dendritic cells (DC) is an important strategy for viral pathogens to evade host defences. In this context, porcine circovirus type 2 (PCV2), a single-stranded DNA vir... | 1153 | 7370282 | [
"8596357",
"8563659",
"6767271",
"15337254"
] | scientific_claim_retrieval | scientific |
9258c99937ef4474a5e0b1e0f04a8d90 | mteb/scifact | Glucose restriction to 0.05% reduces RLS (replicative life span) by 20-40% in S. cerevisiae. | Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals. We established a model of CR in budding yeast Saccharomyces cerevisiae. In this system, li... | [
"Yeast sirtuins and the regulation of aging.. The sirtuins are a phylogenetically conserved family of NAD(+) -dependent protein deacetylases that consume one molecule of NAD(+) for every deacetylated lysine side chain. Their requirement for NAD(+) potentially makes them prone to regulation by fluctuations in NAD(+)... | 472 | 4414481 | [
"1754001",
"4463811",
"9310407",
"323335"
] | scientific_claim_retrieval | scientific |
70d9cd07c8411460f1c71d1b3a9832af | mteb/scifact | Klf4 is not required for proper myeloid cell differentiation. | Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo.. Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood and immune cell types. We demonstrate in this study that hematopoietic cells... | [
"The polycomb group protein Suz12 is required for embryonic stem cell differentiation.. Polycomb group (PcG) proteins form multiprotein complexes, called Polycomb repressive complexes (PRCs). PRC2 contains the PcG proteins EZH2, SUZ12, and EED and represses transcription through methylation of lysine (K) 27 of hist... | 669 | 25148216 | [
"1744097",
"11289247",
"42035464",
"25858295"
] | scientific_claim_retrieval | scientific |
19a18996bdd3e6e4e6d9cf4b50a67a36 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Skincare experts offer advice for those wearing face masks for long periods | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 6how4emi | [
"5bwsb265",
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"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
edb7a2e40d4ce5aeb68d414eea29eafc | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Custom-Fit Three-Dimensional-Printed BiPAP Mask to Improve Compliance in Patients Requiring Long-Term Noninvasive Ventilatory Support. Noninvasive ventilator support using bi-level positive airway pressure/continuous positive airway pressure (BiPAP/CPAP) is commonly utilized for chronic medical conditions like sleep ap... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | hyn9shju | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
523467b6c252a8406c352b15df36866b | mteb/scifact | Ribosomal protein (RP) expression is controlled in part by stress-activated regulators. | Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling. Healthy cells utilize intricate systems to monitor their environment and mount robust responses in the event of cellular stress. Whether stress arises from external insults or defects due to mutation and disease, ... | [
"Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 dir... | 1046 | 16712164 | [
"17055665",
"16527698",
"4795303",
"1605392"
] | scientific_claim_retrieval | scientific |
5b9f006bc4260638b6d16cc4bb5c3da3 | mteb/scifact | Women are more susceptible to death due to pneumonia when compared to men. | Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.. CONTEXT While it is established that management strategies and outcomes differ by gender for many diseases, its effect on infection has not been adequately studied. OBJECTIVE To investigate the role of gender among hospi... | [
"Cardiovascular risk factors and migraine: the GEM population-based study.. BACKGROUND Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an increased risk profile for cardiovascular disease. In this... | 1378 | 2488880 | [
"23785605",
"29253460",
"45027320",
"16812091"
] | scientific_claim_retrieval | scientific |
00e963bd41f940d1f3c8021f196708bb | mteb/scifact | Albendazole is used to treat soil-transmitted helminths. | “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor. Over the past two decades there have been significant achievements in the control of a handful of important human tropical infections [1]. These achievements include the substantive reductio... | [
"Spatial co-distribution of neglected tropical diseases in the east African great lakes region: revisiting the justification for integrated control.. OBJECTIVE To determine spatial patterns of co-endemicity of schistosomiasis mansoni and the soil-transmitted helminths (STHs) Ascaris lumbricoides, Trichuris trichiur... | 95 | 1215116 | [
"13966946",
"5704562",
"27240699",
"34025053"
] | scientific_claim_retrieval | scientific |
49a267c7eccea56649d6f1eb4c5714a4 | mteb/scifact | Removal of H3K9me3 improves reprogramming efficiency in human somatic cell nuclear transfer experiments. | H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming.. Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight-cell SCNT ... | [
"Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells.. The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation fr... | 1036 | 4547102 | [
"15803282",
"4410181",
"4457834",
"21380232"
] | scientific_claim_retrieval | scientific |
8e5a21708d882ccfb6c5b3485bcc9fe2 | mteb/scifact | Vitamin D deficiency effects birth weight. | Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies.. OBJECTIVE To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. DESIGN Systematic review and meta-analysis. DA... | [
"Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency. Vitamin D insufficiency is common, however within individuals, not all manifest the biochemical effects of PTH excess. This further extends to patients with established osteoporosis. The mechanism un... | 1367 | 2425364 | [
"13312471",
"11360768",
"8856690",
"19799455"
] | scientific_claim_retrieval | scientific |
47da214faa5d6d574dd854d80be5ea27 | mteb/scifact | Origin gross domestic product(GDP) is negatively related to dengue virus (DENV-1) diffusion in air traffic shipments. | Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis. BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households without tap water supply, and occurs in high numbers even in dense urban areas. We analy... | [
"Isolation and partial characterization of an unusual human immunodeficiency retrovirus from two persons of west-central African origin.. An unusual human retrovirus was isolated from two patients with persistent generalized lymphadenopathy who originate from West-Central Africa and are currently residing in Belgiu... | 890 | 2097256 | [
"29134911",
"15670968",
"42387637",
"121001457"
] | scientific_claim_retrieval | scientific |
778bfc313365c9493f686dcc4ef117a9 | mteb/scifact | Ethanol stress lowers the expression of PSP in bacteria. | Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, ... | [
"The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells. Human Period 2 (hPer2) is a transcriptional regulator at the core of the circadian clock mechanism that is responsible for generating the negative feedback loop that sustains the clock. Its relevance to human di... | 392 | 1148122 | [
"14367469",
"22517564",
"238409",
"23397658"
] | scientific_claim_retrieval | scientific |
9513495cc011bc2bb8087a0235d03569 | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | Transmissibility and temporal changes of 2009 pH1N1 pandemic during summer and fall/winter waves. BACKGROUND: In order to compare the transmissibility of the 2009 pH1N1 pandemic during successive waves of infections in summer and fall/winter in the Northern Hemisphere, and to assess the temporal changes during the cour... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | ztc5holk | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
ddc5cd9848634108b21730fbc64b9f15 | mteb/scifact | Sympathetic nerve activity is elevated throughout normal pregnancy. | Sympathetic baroreflex gain in normotensive pregnant women.. Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting. We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregn... | [
"Sympathetic activation during early pregnancy in humans.. Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. Whether sympathetic overactivity develops early during pregnancy, remaining high throu... | 1119 | 18997216 | [
"26710772",
"20418809",
"42441846",
"4409524"
] | scientific_claim_retrieval | scientific |
c0144ba31512483776dcda6d2df95ce6 | mteb/scifact | Microcin J25 inhibits nucleoside triphosphate (NTP) binding. | Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel.. The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP). Biochemical results indicate that inhibition of transcription occurs at the level ... | [
"Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases.. Platelet inhibitors are the mainstay treatment for patients with vascular diseases. The current 'gold standard' antiplatelet agent clopidogrel has several pharmacological and clinical limitations that ha... | 788 | 4740447 | [
"25543207",
"20675284",
"1454773",
"22495397"
] | scientific_claim_retrieval | scientific |
5448fd6fcb40f15fd74822f08ff16d16 | mteb/scifact | KRT17 modulates the expression of the transcriptional regulator AIRE in diseased epithelia. | Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratified and pseudostratified epithelia. We report that autoimmune regulator (A... | [
"Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability. Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarra... | 665 | 12580014 | [
"14863011",
"13964633",
"14367469",
"37204802"
] | scientific_claim_retrieval | scientific |
ac16249c2843022cb65e40b9d2b81bcf | mteb/scifact | Mutations in RIM1 raise levels of IME1 RNA. | Molecular characterization of the yeast meiotic regulatory gene RIM1.. In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expression of IME1, which is required for expression of many meiotic genes, and thus lead to a pa... | [
"Inter- and Intra-Host Viral Diversity in a Large Seasonal DENV2 Outbreak. BACKGROUND High genetic diversity at both inter- and intra-host level are hallmarks of RNA viruses due to the error-prone nature of their genome replication. Several groups have evaluated the extent of viral variability using different RNA v... | 816 | 8148304 | [
"16172576",
"19255949",
"24725136",
"33370"
] | scientific_claim_retrieval | scientific |
5bbd594effce9bbab97f97e01c924c41 | mteb/scifact | IL-6 signaling plays a major role in atherosclerotic cardiovascular disease. | Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. BACKGROUND Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades... | [
"the Development of Autoimmune Myocarditis in Mice by an. BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma. Methods and ... | 548 | 18199839 | [
"8246922",
"25453683",
"6767271",
"9334631"
] | scientific_claim_retrieval | scientific |
b5745b4d0be012f62fd888cbd749b239 | mteb/scifact | H4 G94P proteins suppress degradation of free histones via Rad53-dependent mechanisms. | Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis. Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stop... | [
"Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors.. The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins--p21(Cip1/WAF1), p27(Kip1), and p57(Kip2)--that bind and inhibit cyclin-CDK complexes, which are key regulators of the cell cycle. CIP/K... | 487 | 14637235 | [
"6784372",
"28704738",
"502591",
"32408470"
] | scientific_claim_retrieval | scientific |
fee4401b69c34543cf7e64d148739e77 | mteb/scifact | The peak incidence of fractures occurs during pubertal growth spurt in early adolescents. | Incidence of childhood distal forearm fractures over 30 years: a population-based study.. CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time of a transient deficit in cortical bone mass due to the inc... | [
"Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk.. Epidemiologic studies suggest that ovarian hormones contribute to the development of breast cancer at all stages. Early menopause and premenopausal obesity reduces the risk while postmenopausal obesity and menopausal estrogen repla... | 1248 | 7209559 | [
"5864770",
"26409363",
"42080024",
"26720366"
] | scientific_claim_retrieval | scientific |
1d9ad5b9984343ff1c23f8526bf71f97 | mteb/scifact | Sn is present on mature DCs during inflammation in vivo. | Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides. Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cel... | [
"Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the molecular mechanisms of which are only partially elucidated. In this study, we describe a survival pathway controlle... | 1091 | 2603304 | [
"15248287",
"22705234",
"6333347",
"854417"
] | scientific_claim_retrieval | scientific |
f10e4f01675dd6276e5e3abf6f6e781a | mteb/scifact | Diabetes remission occurs less in people treated with conventional therapy than in people treated with laparoscopic adjustable gastric banding surgery. | Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial.. CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. OBJECTIVE To determine if surgically induced weight loss results in better glycemic control ... | [
"Amylase, Lipase, and Acute Pancreatitis in People With Type 2 Diabetes Treated With Liraglutide: Results From the LEADER Randomized Trial.. OBJECTIVE To evaluate serum amylase and lipase levels and the rate of acute pancreatitis in patients with type 2 diabetes and high cardiovascular risk randomized to liraglutid... | 340 | 7098463 | [
"32850528",
"4883040",
"28806780",
"70516463"
] | scientific_claim_retrieval | scientific |
3fdac3a6c51adae2a97a95c1b6049660 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Medical Ethics in Disasters. Disasters frequently create demands that outstrip available existing medical and societal resources. This may be particularly problematic for giving medical care, because disasters may destroy the infrastructures necessary to both provide patients care and keep new health problems from emer... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | favf1hh3 | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
95d2650172c1b163becdd932bd7b86e7 | mteb/scifact | Higher plasma levels of I-carnitine, when associated with trimethylamine N-oxide, are positively correlated with cardiovascular events in humans. | Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metaboli... | [
"Transmission of atherosclerosis susceptibility with gut microbial transplantation.. Recent studies indicate both clinical and mechanistic links between atherosclerotic heart disease and intestinal microbial metabolism of certain dietary nutrients producing trimethylamine N-oxide (TMAO). Here we test the hypothesis... | 524 | 14803797 | [
"33684572",
"24632480",
"10072941",
"31564409"
] | scientific_claim_retrieval | scientific |
b9015553c3e7a1f861b2e342a915c63c | mteb/scifact | During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 5' of strand breaks as compared to 3' strand breaks. | The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining. Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined. We sought to address this question ... | [
"Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.. Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic ... | 358 | 18111172 | [
"20821402",
"12207340",
"25838286",
"15472716"
] | scientific_claim_retrieval | scientific |
8f9eea4d965c6ce996c413b0f76cb60e | mteb/scifact | The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs). | RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of se... | [
"CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human. Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. O... | 1181 | 3952288 | [
"3531388",
"10162553",
"13989491",
"18414462"
] | scientific_claim_retrieval | scientific |
f1d6f384ba20b652353bfca5f54d7f6d | mteb/scifact | H4 G94P proteins induce degradation of free histones via Rad53-dependent mechanisms. | Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis. Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stop... | [
"Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism.. BACKGROUND & AIMS GS-9620, an oral agonist of toll-like receptor 7 (TLR7), is in clinical development for the treatment of chronic hepatitis B (CHB). GS-9620 was previously shown to induce prolong... | 485 | 14637235 | [
"20960682",
"12240507",
"32408470",
"8460275"
] | scientific_claim_retrieval | scientific |
16a5981ce58f3a5d334d0cf9e3a307f5 | mteb/scifact | The artifactual C-terminal helix swapping in the StART domain is observed in the Ups1-Mdm35 heterodimer of the StARkin superfamily. | Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria. Eukaryotic cells are compartmentalized into membrane-bounded organelles whose functions rely on lipid trafficking to achieve membrane-specific compositions of lipids. Here we focused on the Ups1-Mdm35 system, which mediates ph... | [
"RKIKK motif in the intracellular domain is critical for spatial and dynamic organization of ICAM-1: functional implication for the leukocyte adhesion and transmigration.. No direct evidence has been reported whether the spatial organization of ICAM-1 on the cell surface is linked to its physiological function in t... | 1195 | 26283293 | [
"33920995",
"2316374",
"44935041",
"36464673"
] | scientific_claim_retrieval | scientific |
95f12393b94b8136a79a6172033c7017 | mteb/scifact | Alteration of origin firing causes changes in termination zones of Okazaki fragments. | Quantitative, genome-wide analysis of eukaryotic replication initiation and termination.. Many fundamental aspects of DNA replication, such as the exact locations where DNA synthesis is initiated and terminated, how frequently origins are used, and how fork progression is influenced by transcription, are poorly underst... | [
"Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.. Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but the detailed mechanisms are largely unknown. Our previous study has shown that autophagy is a... | 105 | 36606083 | [
"24632480",
"6153754",
"15365719",
"19961177"
] | scientific_claim_retrieval | scientific |
76877c04a4d2750dac50ccb82aabee22 | mteb/scifact | Ca2+ cycling is a UCP1-dependent thermogenic mechanism. | UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent ... | [
"CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation. Mitochondrial permeability transition pore (mPTP) is involved in cardiac dysfunction during chronic β-adrenergic receptor (β-AR) stimulation. The mechanism by which chronic β-AR stimulation leads to mPTP openings i... | 221 | 19205437 | [
"14362678",
"4319174",
"2039912",
"17338543"
] | scientific_claim_retrieval | scientific |
68f1fb32dfbd16d9c4db2fc4a34062c5 | mteb/scifact | CRP is positively correlated with postoperative mortality following Coronary Artery Bypass Graft (CABG) surgery. | Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery. OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients... | [
"Preoperative C-reactive protein predicts long-term mortality and hospital length of stay after primary, nonemergent coronary artery bypass grafting.. BACKGROUND Preoperative C-reactive protein (CRP) levels more than 10 mg/l have been shown to be associated with increased morbidity and mortality after cardiac surge... | 214 | 13625993 | [
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"20887554",
"750781",
"7813993"
] | scientific_claim_retrieval | scientific |
f5036e98b3c268057a10b9d7b2347c7b | mteb/scifact | ScPif1p has reduced binding ability to G-rich ssDNA compared to non-G-rich ssDNA. | Pif1 family helicases suppress genome instability at G-quadruplex motifs. The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases. Mo... | [
"Role of the Single-Stranded DNA–Binding Protein SsbB in Pneumococcal Transformation: Maintenance of a Reservoir for Genetic Plasticity. Bacteria encode a single-stranded DNA (ssDNA) binding protein (SSB) crucial for genome maintenance. In Bacillus subtilis and Streptococcus pneumoniae, an alternative SSB, SsbB, is... | 1068 | 4429668 | [
"799586",
"10486817",
"2758012",
"11742219"
] | scientific_claim_retrieval | scientific |
8973e65344d6b6d14cd25a5ad1a2eeaa | mteb/scifact | The density of cytokine receptor bearing cells has no effect on the distance over which cytokines act. | A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System. &NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, we used t... | [
"Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.. Although TNF is a major proinflammatory cytokine, increasing evidence indicates that TNF also has immunosuppressive feedback effects. We have demonstrated in this study that, in both resting and acti... | 1211 | 4928282 | [
"38830961",
"5828251",
"24707550",
"9334631"
] | scientific_claim_retrieval | scientific |
f528641104a7f3019dd73f0670bfdc5b | mteb/trec-covid | how long does coronavirus remain stable on surfaces? | Hand touches on the surfaces of a healthcare waiting area | [
"Infections and immunological hazards of allogeneic bone transplantation. Allogeneic transplantation of human cancellous and cortical bone is a controversially discussed concept in trauma and orthopaedic surgery. Biological and immunological arguments support transplantation of autologous material whenever this is ... | 16 | vozeou25 | [
"tle1j3xv",
"wuy3cwhu",
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"mne96c9i"
] | biomedical_literature_retrieval | scientific |
762132d7da4f82cdeb59a5ec45680576 | mteb/scifact | Participants who quit smoking reduce lung cancer risk by approximately 50%. | Effect of smoking reduction on lung cancer risk.. CONTEXT Many smokers are unable or unwilling to completely quit smoking. A proposed means of harm reduction is to reduce the number of cigarettes smoked per day. However, it is not clear whether this strategy decreases the risk for tobacco-related diseases. OBJECTIVE To... | [
"Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort.. OBJECTIVE To compare the incidence of cancer among women with and without a history of pre-eclampsia. DESIGN Cohort study. SETTING Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-... | 919 | 16422880 | [
"15512462",
"7639744",
"7613033",
"20471181"
] | scientific_claim_retrieval | scientific |
d98f3c4695fa5078efbfdade85659b14 | mteb/scifact | 1 in 5 million in UK have abnormal PrP positivity. | Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey. OBJECTIVES To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions after th... | [
"Hemoglobin concentration in white, black, and Oriental children: is there a need for separate criteria in screening for anemia?. The concentration of hemoglobin in blacks was found to be 0.5 to 1.0 g/dl lower than that of income-matched whites in several large surveys. This difference could be a racial characteris... | 2 | 13734012 | [
"4449524",
"29090823",
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"834336"
] | scientific_claim_retrieval | scientific |
3ab1da64055a06d4c87d0ac61edc2207 | mteb/trec-covid | what is the origin of COVID-19 | Wildlife Trade and the Emergence of Infectious Diseases. Most recent emerging infectious diseases have been zoonotic in origin. It is our contention that one of the factors responsible for such emergence is the trade in wildlife and bushmeat in particular. This article considers the effect of increasing diversity in th... | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | 2arx86a6 | [
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] | biomedical_literature_retrieval | scientific |
6ea2f3d3ad14f90fb156684c5b070663 | mteb/scifact | RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells. | Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium. The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embry... | [
"Control of central and peripheral tolerance by Aire.. The negative selection of self-reactive thymocytes depends on the expression of tissue-specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even ... | 1005 | 301838 | [
"39559521",
"13989491",
"10162553",
"17844478"
] | scientific_claim_retrieval | scientific |
a71b61187b3d10e273c18249cd17d9dd | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | Pandemic school closures: risks and opportunities | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | ewah8x7m | [
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"3emzk5by"
] | biomedical_literature_retrieval | scientific |
31e72033f881567d50a65f9d0795e763 | mteb/scifact | Bariatric surgery leads to negative outcomes in mental health. | Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis.. IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese individuals. Mental health conditions may be common among patients seeking bariatric surgery; h... | [
"Recommendations for the presurgical psychosocial evaluation of bariatric surgery patients.. Psychosocial factors have significant potential to affect long-term outcomes of bariatric surgery, including emotional adjustment, adherence to the recommended postoperative lifestyle regimen, weight loss outcomes, and co-m... | 166 | 18872233 | [
"29022271",
"24988745",
"4993011",
"31612088"
] | scientific_claim_retrieval | scientific |
70264bb828f4a7e13853c80c2304078d | mteb/scifact | The tip of the inner tube of the toxic type VI secretion system (T6SS) antibacterial effector in Escherichia coli (E. coli) is decorated with VgrG and PAAR proteins. | A view to a kill: the bacterial type VI secretion system.. The bacterial type VI secretion system (T6SS) is an organelle that is structurally and mechanistically analogous to an intracellular membrane-attached contractile phage tail. Recent studies determined that a rapid conformational change in the structure of a she... | [
"PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike. The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS is responsible for translocation of a wide range of t... | 1275 | 27731651 | [
"4406819",
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"22632303",
"17208742"
] | scientific_claim_retrieval | scientific |
e594238c2be7247562de1db19d1e785f | mteb/scifact | Activated Cdk5 regulates DNA damage-induced neuronal death. | Phosphorylation of ATM by Cdk5 mediates DNA damage signaling and regulates neuronal death. The phosphatidylinositol-3-kinase-like kinase ATM (ataxia-telangiectasia mutated) has a central role in coordinating DNA damage responses, including cell-cycle checkpoint control, DNA repair and apoptosis. Mutations of ATM cause ... | [
"DNA repair factor APLF is a histone chaperone.. Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modulates chromatin remains poorly understood. Here we ide... | 68 | 21295300 | [
"13907427",
"25510546",
"21521236",
"12909503"
] | scientific_claim_retrieval | scientific |
1f5061b5f83e707ef33d6650d706b8d6 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Forecasting national and regional influenza-like illness for the USA. Health planners use forecasts of key metrics associated with influenza-like illness (ILI); near-term weekly incidence, week of season onset, week of peak, and intensity of peak. Here, we describe our participation in a weekly prospective ILI forecast... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | zfztgfv3 | [
"g7pigmgc",
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"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
640af53807b515f5d298facf2b741e83 | mteb/scifact | Perigenital skin is not the primary site of HIV acquisition. | Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition. To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV... | [
"Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8-positive solid lymphomas: a tissue-based variant of primary effusion lymphoma.. Kaposi's sarcoma-associated herpesvirus (KSHV), also termed human herpesvirus type 8, is consistently identified in Kaposi's sarcoma, primary effusion lymphoma (PEL), and... | 934 | 8563659 | [
"11238951",
"2474731",
"4421578",
"6334188"
] | scientific_claim_retrieval | scientific |
30923019a43d7823ccf56566ef369be6 | mteb/scifact | HbA1c consistently overestimates glycemic control in black individuals with Sickle cell trait (SCT). | Association of Sickle Cell Trait With Hemoglobin A1c in African Americans. Importance Hemoglobin A1c (HbA1c) reflects past glucose concentrations, but this relationship may differ between those with sickle cell trait (SCT) and those without it. Objective To evaluate the association between SCT and HbA1c for given level... | [
"Reversing the tide — diagnosis and prevention of T2DM in populations of African descent. Abstract | Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). The burden of T2DM is amplified by diagnosis after preventable complications of the disease have occu... | 499 | 26064662 | [
"12662435",
"23206239",
"30983338",
"4378885"
] | scientific_claim_retrieval | scientific |
50fc9e43699952a614630db7865009b9 | mteb/scifact | Distant CREs are important for transcriptional regulation. | Enhancer Evolution across 20 Mammalian Species. The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian specie... | [
"Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM.. Transcriptional factors binding to cAMP-responsive elements (CREs) in the promoters of various genes belong to the basic domain-leucine zipper superfamily and are composed of three genes in mammals, CREB, CREM, and ATF-1. A larg... | 351 | 14658685 | [
"21622715",
"3052213",
"20028729",
"17829012"
] | scientific_claim_retrieval | scientific |
6bb46725aa9224e68802f97df7f78b14 | mteb/scifact | RAD52 is involved in break-induced DNA replication (BIR). | Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks. Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To bette... | [
"Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the molecular mechanisms of which are only partially elucidated. In this study, we describe a survival pathway controlle... | 1003 | 14332945 | [
"15248287",
"6144969",
"34198365",
"7468449"
] | scientific_claim_retrieval | scientific |
2dd517311dce1b8856981274b16326b7 | mteb/scifact | Energy balance requires hypothalamic glutamate neurotransmission. | Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting. In the hypothalamic arcuate nucleus (ARC), pro-opiomelanocortin (POMC) neurons inhibit feeding and neuropeptide-Y (NPY) neurons stimulate feeding. We tested whether neurons in the ventromedial hypothalamic nucleus (VMH), a k... | [
"The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.. BACKGROUND Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Syste... | 378 | 25007443 | [
"4700428",
"16398827",
"2481032",
"14782049"
] | scientific_claim_retrieval | scientific |
1cd4b9976778b4fededc9bbff448fbc8 | mteb/trec-covid | what is known about those infected with Covid-19 but are asymptomatic? | On the Role of Asymptomatic Infection in Transmission Dynamics of Infectious Diseases. We propose a compartmental disease transmission model with an asymptomatic (or subclinical) infective class to study the role of asymptomatic infection in the transmission dynamics of infectious diseases with asymptomatic infectives,... | [
"Functional community structure of African monodominant Gilbertiodendron dewevrei forest influenced by local environmental filtering. Monodominant patches of forest dominated by Gilbertiodendron dewevrei are commonly found in central African tropical forests, alongside forests with high species diversity. Although ... | 27 | ramd5lit | [
"clirh04i",
"mj63cvwe",
"yc8rjjyf",
"v8lpw4r7"
] | biomedical_literature_retrieval | scientific |
3ca1c70643ce1a2bde7162486eccfcce | mteb/trec-covid | what kinds of complications related to COVID-19 are associated with hypertension? | B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Angiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular physiology and pathology, and is currently clinically evaluated to treat acute lung failure. Here we show that the B38-CAP, a carboxypeptid... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 23 | aj7ybyl0 | [
"beqvgdjo",
"694a1jef",
"cnygzwkw",
"ucthbqvt"
] | biomedical_literature_retrieval | scientific |
a7a381577b1aeb923a306ffdc25d05ad | mteb/scifact | Metastatic colorectal cancer treated with a single agent fluoropyrimidines resulted in similar efficacy and better quality of life when compared with oxaliplatin-based chemotherapy in elderly patients. | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. BACKGROUND Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical trials. We designed FOCUS2 to investigate reduced-d... | [
"Comparative Safety of Targeted Therapies for Metastatic Colorectal Cancer between Elderly and Younger Patients: a Study Using the International Pharmacovigilance Database. Metastatic colorectal cancer (mCRC) is increasingly treated using targeted therapies. Post-marketing safety of these agents is understudied, es... | 771 | 15476777 | [
"2492146",
"5151024",
"10582939",
"35301079"
] | scientific_claim_retrieval | scientific |
80d75d740217d182b5f3c514bbc6c027 | mteb/trec-covid | how has lack of testing availability led to underreporting of true incidence of Covid-19? | Reporting errors in infectious disease outbreaks, with an application to Pandemic Influenza A/H1N1. BACKGROUND: Effectively responding to infectious disease outbreaks requires a well-informed response. Quantitative methods for analyzing outbreak data and estimating key parameters to characterize the spread of the outbr... | [
"Solidarity, vulnerability and mistrust: how context, information and government affect the lives of women in times of Zika. BACKGROUND: The public health response to Zika outbreak has mostly focused on epidemiological surveillance, vector control, and individual level preventative measures. This qualitative study ... | 8 | 2ad1tu4s | [
"wlbja1gz",
"p2j4m552",
"lwvb6dxc",
"qjab20j6"
] | biomedical_literature_retrieval | scientific |
a2ee7e062a9b54604f3e7a3a37ddde6e | mteb/scifact | Vaccinating the gastrointestinal tract induces protection of rectal and vaginal mucosa. | Large intestine-targeted nanoparticle-releasing oral vaccine to control genitorectal viral infection. Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms. Vaccination through large intestinal mucosa, previously proven protective for both of these mucosal sites in animal s... | [
"Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infected individuals develop a life-threatening bacteremia. Here we show that simian immuno... | 1356 | 13764090 | [
"29023309",
"34733465",
"6372244",
"21956124"
] | scientific_claim_retrieval | scientific |
b9fdf91d24ac8ea777e24fe92fdd293b | mteb/scifact | Notch signaling occurs between tumor cells and stromal cells. | Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells.. Notch receptors expressed on hematopoietic stem cells interact with their ligands on bone marrow stromal cells and thereby control cell fate decisions and survival. We recently demonstrated that Notch signaling is involved in proliferation... | [
"BRAF mutation predicts for MEK-dependence in non-small cell lung cancer (NSCLC).. 5247 Constitutive ERK signaling is common in human cancer and is often the result of activating mutations of BRAF, RAS and upstream receptor tyrosine kinases. Missense BRAF kinase domain mutations are frequently observed in melanoma,... | 863 | 16361581 | [
"85665741",
"26735905",
"9831859",
"23509593"
] | scientific_claim_retrieval | scientific |
23d879c75667c83ea197f03fd8c4186e | mteb/scifact | Cost effectiveness evaluations based on cRCT data accurately reflect prices for patients in actual clinical practice. | A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example. BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of this st... | [
"Surgical vs nonsurgical treatment of adults with displaced fractures of the proximal humerus: the PROFHER randomized clinical trial.. IMPORTANCE The need for surgery for the majority of patients with displaced proximal humeral fractures is unclear, but its use is increasing. OBJECTIVE To evaluate the clinical effe... | 290 | 15048300 | [
"44048701",
"23206239",
"13625993",
"7454794"
] | scientific_claim_retrieval | scientific |
0dd0fe12a3278bad4e85b59a75e33fec | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Climate impact on spreading of airborne infectious diseases: Complex network based modeling of climate influences on influenza like illnesses. In this study we combined a wide range of data sets to simulate the outbreak of an airborne infectious disease that is directly transmitted from human to human. The basis is a c... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | 6zi7sxs1 | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
d43cb2c63d0512bde068b24f9e6fb418 | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Investigation of Antibody-Dependent Enhancement (ADE) of SARS coronavirus infection and its role in pathogenesis of SARS | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | oz4vlhck | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
e6e73f120398a3c718bc353a48c7ec78 | mteb/scifact | A mutation in HNF4A leads to an increased risk of diabetes by the age of 14 years. | Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene. Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with... | [
"White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network.. OBJECTIVE White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascu... | 45 | 56893404 | [
"8524891",
"25816994",
"6387956",
"14021596"
] | scientific_claim_retrieval | scientific |
ac5dcb417024e54c1792668eb0000435 | mteb/scifact | Bariatric surgery increases rates of postmenopausal breast cancer. | Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large... | [
"Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk.. Epidemiologic studies suggest that ovarian hormones contribute to the development of breast cancer at all stages. Early menopause and premenopausal obesity reduces the risk while postmenopausal obesity and menopausal estrogen repla... | 165 | 5824985 | [
"5864770",
"24341590",
"5487448",
"21181273"
] | scientific_claim_retrieval | scientific |
0fc779fcc1cc58424be4fc623d2fb3d2 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response. The ability of the host immune response is largely mediated by the proinflammatory cytokine production. Physiological and pathological conditions of endoplasmic reticulum (ER) trigger unfolded protein response and c... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | h8txbd3p | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
4e3dc40c47cdf1a147df539678673798 | mteb/scifact | Upon viral challenge, influenza-specific memory CD4+ T cells greatly enhance the early production of inflammatory chemokines in the lung. | Memory CD4+ T cells induce innate responses independently of pathogen. Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses. W... | [
"Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection.. In this report, we demonstrate that CD28(-/-) mice are severely impaired in the initial expansio... | 1348 | 19005293 | [
"40473317",
"24879055",
"12100963",
"40365566"
] | scientific_claim_retrieval | scientific |
b6eec0ab5625e99f6675db7f679c1737 | mteb/scifact | Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction. | Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia. Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in... | [
"Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.. Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity p... | 1026 | 3113630 | [
"2481032",
"306006",
"10669582",
"20602517"
] | scientific_claim_retrieval | scientific |
4c6f692267613fd654cd0d99ff9e795f | mteb/scifact | COPI coatmer is involved in lipid homeostasis. | COPI Complex Is a Regulator of Lipid Homeostasis. Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin, adipocyte diff... | [
"Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Epidermal homeostasis depends on a balance between stem cell renewal and differentiation and is regulated by extrinsic signals from the extracellular matrix (ECM). A powerful approach t... | 210 | 13794374 | [
"15176526",
"6588614",
"9159125",
"21547032"
] | scientific_claim_retrieval | scientific |
05c5bc545c1364a9b9977cf48f40feb2 | mteb/trec-covid | what are the transmission routes of coronavirus? | SARS legacy: outbreak reporting is expected and respected | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | tcxi884k | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
5ac8a92f74176423b53b4c5b6c9421a2 | mteb/scifact | Primary cervical cancer screening with HPV detection has lower longitudinal sensitivity than conventional cytology to detect cervical intraepithelial neoplasia grade 2. | Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer.. More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods. A summary is given from recent meta-analyses and sys... | [
"Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening.. BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clin... | 972 | 28617573 | [
"6561200",
"16980892",
"76415938",
"46355579"
] | scientific_claim_retrieval | scientific |
a5148ae8ea7e21d8ab633c268e0d4374 | mteb/scifact | The minor G allele of FOXO3 downregulates pro-inflammatory cytokines. | Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway. The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient's life but i... | [
"Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme.. Endothelin-1 (ET-1) is the predominant endothelin isopeptide generated by the vascular wall and therefore appears to be the most important peptide involved in regulation of cardiova... | 1230 | 13905670 | [
"6397191",
"41877386",
"44562221",
"343052"
] | scientific_claim_retrieval | scientific |
fa285741dcfe70ba77c8393dfff3d682 | mteb/scifact | Mutations in RIM1 decrease levels of IME1 RNA. | Molecular characterization of the yeast meiotic regulatory gene RIM1.. In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expression of IME1, which is required for expression of many meiotic genes, and thus lead to a pa... | [
"Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component. Mutations in the PARN gene (encoding poly(A)-specific ribonuclease) cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita, but how PARN deficiency impairs telomere ma... | 815 | 8148304 | [
"19255949",
"15248287",
"7317051",
"34733465"
] | scientific_claim_retrieval | scientific |
57e07013df1dfacb7d68d34eeabb9d14 | mteb/trec-covid | how long does coronavirus remain stable on surfaces? | Resistance of Enteric Viruses on Fomites. Human enteric viruses are associated with several clinical features, especially gastroenteritis. Large amounts of these viruses can be released in the environment and spread to people. Enteric viruses are nonenveloped viruses and have displayed good survival in the environment.... | [
"Infections and immunological hazards of allogeneic bone transplantation. Allogeneic transplantation of human cancellous and cortical bone is a controversially discussed concept in trauma and orthopaedic surgery. Biological and immunological arguments support transplantation of autologous material whenever this is ... | 16 | tqqt0hj7 | [
"tle1j3xv",
"wuy3cwhu",
"q5cmwzr8",
"mne96c9i"
] | biomedical_literature_retrieval | scientific |
63f9f7aaca302ff89a8f2359b18d7930 | mteb/scifact | The mean suicide rate in women is higher after miscarriage than live birth. | Suicides after pregnancy in Finland, 1987-94: register linkage study.. OBJECTIVE To determine rates of suicide associated with pregnancy by the type of pregnancy. DESIGN Register linkage study. Information on suicides in women of reproductive age was linked with the Finnish birth, abortion, and hospital discharge regis... | [
"Attempted suicide in Europe: rates, trends and sociodemographic characteristics of suicide attempters during the period 1989-1992. Results of the WHO/EURO Multicentre Study on Parasuicide.. The World Health Organization/EURO Multicentre Project on Parasuicide is part of the action to implement target 12 of the WHO... | 1227 | 25641414 | [
"25806385",
"18340282",
"5884524",
"14021596"
] | scientific_claim_retrieval | scientific |
f3d2e1765446d876853c2eb7f6866034 | mteb/scifact | Ethanol stress increases the expression of IBP in bacteria. | Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, ... | [
"Evaluation of oxidative status and depression-like responses in Brown Norway rats with acute myeloid leukemia. It has been proved that oxidative stress increases when leukemia is accompanied by depression. This fact may indicate the role of oxidative stress in the development of depression in cancer patients. The ... | 389 | 1148122 | [
"12903921",
"471735",
"25510546",
"10795340"
] | scientific_claim_retrieval | scientific |
f85c9efa13fb3a7e5ec133ae4b585cd9 | mteb/scifact | Oxidative DNA damage activates STING signalling. | Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.. Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a ... | [
"Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage.. Many studies have shown that caloric restriction (40%) decreases mitochondrial reactive oxygen species (ROS) generation in rodents. Moreover, we have recently found that 7 weeks of 40% protein restriction without strong... | 898 | 13106686 | [
"44693226",
"13023410",
"21295300",
"1635872"
] | scientific_claim_retrieval | scientific |
1eae3a13784e6cbf760ae24c3f8433dd | mteb/scifact | Primary pro-inflammatory cytokines suppress secondary pro- and anti-inflammatory mediators. | Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the eff... | [
"Deficiency of Interleukin-15 Confers Resistance to Obesity by Diminishing Inflammation and Enhancing the Thermogenic Function of Adipose Tissues. OBJECTIVE IL-15 is an inflammatory cytokine secreted by many cell types. IL-15 is also produced during physical exercise by skeletal muscle and has been reported to redu... | 976 | 5304891 | [
"52865789",
"6144969",
"29509926",
"27093166"
] | scientific_claim_retrieval | scientific |
ca1fb14e58d0a81a0e6260155a6bab6f | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | Filter quality of electret masks in filtering 14.6–594 nm aerosol particles: Effects of five decontamination methods. This study investigates the effects of five decontamination methods on the filter quality (q(f)) of three commercially available electret masks—N95, Gauze and Spunlace nonwoven masks. Newly developed ev... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | 3kzuvyqx | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
1d606e61dcc08deadb613caf8c0185f5 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Airborne/Droplet Infection Isolation. Airborne/droplet infection is caused by infected agents in the air around a person. Microbial pathogenic agents that are mainly transmitted airborne are aerosols, re-aerosols, microbe-carrying particles, huge amounts of bacteria-carrying airborne skin cells, dust, droplets and drop... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 1x0oqzq0 | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
7ca3a9a4a7e18736cc11f7313f6f5e5e | mteb/scifact | Enhanced early production of inflammatory chemokines damages viral control in the lung. | Memory CD4+ T cells induce innate responses independently of pathogen. Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses. W... | [
"Self-Reactive B Cells in the Germinal Center Reaction.. Maintenance of immunological self-tolerance requires lymphocytes carrying self-reactive antigen receptors to be selectively prevented from mounting destructive or inflammatory effector responses. Classically, self-tolerance is viewed in terms of the removal, ... | 379 | 19005293 | [
"5003144",
"45449835",
"17708753",
"4345315"
] | scientific_claim_retrieval | scientific |
a13888593a59f3bec8780447fee613d5 | mteb/scifact | TRAP+ osteoclasts regulate mature osteoblast maintenance. | PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis. Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), couples angiogenesis and osteogenesis. ... | [
"Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts.. Activated T cells secrete multiple osteoclastogenic cytokines which play a major role in the bone destruction associated with rheumatoid arthritis. While the role of T cells in osteoclastogenesis has re... | 1138 | 6796297 | [
"43619625",
"38899659",
"21257564",
"42662816"
] | scientific_claim_retrieval | scientific |
53b92b4ac38ff6fd51b1da7c71ee8cd5 | mteb/scifact | Interferon stimulated genes (ISGs) Irf1, Irg1, Ifi27, and Rsad2 encourage West Nile virus replication in cortical neurons. | Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses. Although susceptibility of neurons in the brain to microbial infection is a major determinant of clinical outcome, little is known about the molecular factors governing ... | [
"Experimental Evolution of an RNA Virus in Wild Birds: Evidence for Host-Dependent Impacts on Population Structure and Competitive Fitness. Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is redu... | 651 | 9433958 | [
"11016410",
"7155555",
"30437264",
"28644298"
] | scientific_claim_retrieval | scientific |
ac554da8fa33b57954da30ba3f692050 | mteb/scifact | Deleting Raptor increases G-CSF levels. | Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation. Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely variable even among patients harbouring the same type of malignancy, and the mechanisms gov... | [
"Natural history of adult T-cell leukemia/lymphoma and approaches to therapy. After cell-to-cell transmission, HTLV-I increases its viral genome by de novo infection and proliferation of infected cells. Proliferation of infected cells is clonal and persistent in vivo. During the carrier state, infected cells are se... | 323 | 2014909 | [
"20754359",
"188911",
"11565780",
"12785130"
] | scientific_claim_retrieval | scientific |
6691e20e7aeb6daf2f1c2b59e9c95338 | mteb/scifact | Increased microtubule acetylation repairs interference of axonal transport caused by LRRK2 Roc-COR domain mutations. | Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been describe... | [
"ESCRT-III recognition by VPS4 ATPases. The ESCRT (endosomal sorting complex required for transport) pathway is required for terminal membrane fission events in several important biological processes, including endosomal intraluminal vesicle formation, HIV budding and cytokinesis. VPS4 ATPases perform a key functio... | 614 | 9638032 | [
"4429388",
"15600979",
"41644178",
"4993011"
] | scientific_claim_retrieval | scientific |
5f8d2d92720aa6bd76185d9df8e14ee9 | mteb/scifact | Reduction of Rpl38 alters the composition of the Hox gene mRNAs translation in mice without lowering overall protein synthesis. | Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning. Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprisi... | [
"A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus.. Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTP) that endures for more than an hour requires both transcription and... | 1031 | 12486491 | [
"10790846",
"13778710",
"27240699",
"6718824"
] | scientific_claim_retrieval | scientific |
251c49eb18c21206ac2914ef2c32b1a5 | mteb/trec-covid | which SARS-CoV-2 proteins-human proteins interactions indicate potential for drug targets. Are there approved drugs that can be repurposed based on this information? | Immunosuppression by viral N proteins | [
"Single-Particle cryo-EM as a Pipeline for Obtaining Atomic Resolution Structures of Druggable Targets in Preclinical Structure-Based Drug Design. Single-particle cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image processing have gained importance in the last few years to obtain atomic structures o... | 29 | rjrw875d | [
"6m06yzp7",
"njlqgih3",
"mw7athol",
"f089bs8r"
] | biomedical_literature_retrieval | scientific |
508fd527c7e5cca4eca2a42abb73d642 | mteb/trec-covid | what is known about those infected with Covid-19 but are asymptomatic? | Do asymptomatic respiratory viral infections occur? | [
"Functional community structure of African monodominant Gilbertiodendron dewevrei forest influenced by local environmental filtering. Monodominant patches of forest dominated by Gilbertiodendron dewevrei are commonly found in central African tropical forests, alongside forests with high species diversity. Although ... | 27 | pp78g1dx | [
"clirh04i",
"mj63cvwe",
"yc8rjjyf",
"v8lpw4r7"
] | biomedical_literature_retrieval | scientific |
938c79e017d255e2371d0d55f5107a41 | mteb/scifact | Stiff substrates encourage mesodermal differentiation by degrading beta-catenin in an integrin-dependent manner. | Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation.. Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fate. Embryogenesis is guided by cell-cell and cell-matrix interactions, but it is unclear h... | [
"Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation.. There is mounting evidence that tumors are initiated by a rare subset of cells called cancer stem cells (CSCs). CSCs are generally quiescent, self-renew, form tumors at low numbers, and give rise to the ... | 1101 | 3874000 | [
"13779605",
"21564598",
"20313748",
"32797183"
] | scientific_claim_retrieval | scientific |
ccb6cdd025af5a8985d620caddad906d | mteb/trec-covid | what is the origin of COVID-19 | Emerging infectious diseases. The spectrum of human pathogens and the infectious diseases they cause is continuously changing through evolution and changes in the way human populations interact with their environment and each other. New human pathogens most often emerge from an animal reservoir, emphasizing the central... | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | 0e1w86tg | [
"o0syp1wb",
"hs2vni8z",
"35c6mak0",
"72s8wpla"
] | biomedical_literature_retrieval | scientific |
b09fdfc6ab87ec32fd5c3e4e9d9a7754 | mteb/scifact | Cognitive behavioral therapy is an ineffective treatment for insomnia | Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial.. CONTEXT Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychological consequences. Previous research has suggested benefici... | [
"Gene therapy of arthritis with TCR isolated from the inflamed paw.. In recent years, the treatment of autoimmune diseases has been significantly advanced by the use of biological agents. However, some biologics are accompanied with severe side effects, including tuberculosis and other types of infection. There is ... | 267 | 5912283 | [
"14834714",
"16787954",
"27127885",
"46353045"
] | scientific_claim_retrieval | scientific |
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