Abeshith/research-embedding-finetuned
Sentence Similarity • 0.1B • Updated • 8
id stringlengths 32 32 | source_dataset stringclasses 2
values | query stringlengths 26 249 | positive stringlengths 20 1.8k | negatives listlengths 4 4 | query_id stringlengths 1 4 | positive_id stringlengths 4 9 | negative_ids listlengths 4 4 | task_type stringclasses 2
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|---|---|---|---|---|---|---|---|---|---|
86ef4b3968279ffb992c429a14086287 | mteb/scifact | Energy balance requires hypothalamic glutamate neurotransmission. | Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.. The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate ... | [
"The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.. BACKGROUND Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Syste... | 378 | 11886686 | [
"4700428",
"16398827",
"2481032",
"14782049"
] | scientific_claim_retrieval | scientific |
831287202563c6c2fcfa825e9b0ab7e3 | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross. Enhanced host protection against re-infection requires generation of memory T cells of sufficient quantity and functional quality. Unlike well-studied inbred mice, T cell responses of diverse size and quality are generated following in... | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | kvmjkknp | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
550766ca15af34d0c7a266242fa99a2d | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | A highly specific rapid antigen detection assay for on-site diagnosis of MERS | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | 7l8boeom | [
"6324190r",
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] | biomedical_literature_retrieval | scientific |
c813c64a6c8e9fb85daa2d6064c66eaf | mteb/trec-covid | is remdesivir an effective treatment for COVID-19 | Remdesivir, the antiviral hope against SARS-CoV-2/ Remdesivir, la esperanza antiviral frente al SARS-CoV-2. On December 31, 2019 a pneumonia outbreak caused by a new coronavirus (SARS-CoV-2) was detected in the city of Wuhan (China) Due to the high capacity of diffusion and human infection it has become a new zoonotic ... | [
"Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms. BACKGROUND: Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common infectious species ... | 30 | puc13jf1 | [
"ygf165x2",
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"y47fq64r",
"5c1rhmmm"
] | biomedical_literature_retrieval | scientific |
8af7a0f3267618e71fcd2935fd01684f | mteb/scifact | Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility. | Functional role of high-affinity anandamide transport, as revealed by selective inhibition.. Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely understood, but it may occur by transport into ce... | [
"PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.. AMP-activated protein kinase (AMPK) is an energy-sensing enzyme whose activity is inhibited in settings of insulin resistance. Exposure to a high glucose concentration has recently been shown to incr... | 1325 | 40476126 | [
"23974474",
"10207180",
"45153864",
"15563864"
] | scientific_claim_retrieval | scientific |
26a6bdddddea94af1f77597f2bc65307 | mteb/trec-covid | what drugs have been active against SARS-CoV or SARS-CoV-2 in animal studies? | Remdesivir, the antiviral hope against SARS-CoV-2/ Remdesivir, la esperanza antiviral frente al SARS-CoV-2. On December 31, 2019 a pneumonia outbreak caused by a new coronavirus (SARS-CoV-2) was detected in the city of Wuhan (China) Due to the high capacity of diffusion and human infection it has become a new zoonotic ... | [
"Emerging Animal Coronaviruses: First SARS and Now MERS. The first major pandemic of the new millennium that arose from southern China in 2002 was of zoonotic origin from wild game animals, called severe acute respiratory syndrome [SARS]. The culprit was determined to be a coronavirus of animal origin [SARS-CoV]. T... | 5 | puc13jf1 | [
"3114rz8f",
"qilqtvzt",
"zrobpop6",
"isvkp4d1"
] | biomedical_literature_retrieval | scientific |
0dff6b198f40a001534e2ee916932b8a | mteb/scifact | Cell autonomous sex determination in somatic cells occurs in Galliformes. | Somatic sex identity is cell-autonomous in the chicken. In the mammalian model of sex determination, embryos are considered to be sexually indifferent until the transient action of a sex-determining gene initiates gonadal differentiation. Although this model is thought to apply to all vertebrates, this has yet to be es... | [
"Nanog safeguards pluripotency and mediates germline development. Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and developing germ cells. Deletion of Nanog causes early embryonic lethality, whereas constitutive expression enables autonomous self-renewal of embryonic stem cells. Nano... | 235 | 4388470 | [
"4423327",
"15803282",
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] | scientific_claim_retrieval | scientific |
fd6972d98bf0cc9971176bad328da724 | mteb/scifact | The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling. | YOKO HONDA AND SHUJI HONDA 1. Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) for... | [
"Influence of Steroid Hormone Signaling on Life Span Control by Caenorhabditis elegans Insulin-Like Signaling. Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormone... | 1219 | 14864285 | [
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"1576955",
"29429111"
] | scientific_claim_retrieval | scientific |
5c5a2ff160fb76972eae22fef9572b7e | mteb/scifact | RUNX is not expressed in skin tissue. | Human epidermal stem cell function is regulated by circadian oscillations.. Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differe... | [
"Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.. This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema III) following lesions to the rat C... | 1008 | 2547636 | [
"33535447",
"19427410",
"11238951",
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] | scientific_claim_retrieval | scientific |
050d99aeba8b061d29b9771a1df8988c | mteb/scifact | β1/Ketel is able to bind microtubules. | A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis. The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associate... | [
"Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.. Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (... | 1407 | 8087082 | [
"21164071",
"45199834",
"2151983",
"9638032"
] | scientific_claim_retrieval | scientific |
2043f261ed291832b418a0f5b4cc1efe | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | T follicular regulatory cells infiltrate the human airways during the onset of acute respiratory distress syndrome and regulate the development of B regulatory cells. T follicular regulatory (Tfr) cell is a CXCR5(+)Foxp3(+) subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses a... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 61ezrjuq | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
c30799e4dfed31fd533b1376f3f294cc | mteb/scifact | miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells. | microRNAs: A Safeguard against Turmoil?. Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during st... | [
"CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control.. MicroRNAs (miRNAs) are a recently identified class of epigenetic elements consisting of small noncoding RNAs that bind to the 3' untranslated region of mRNAs and down-regulate their translation... | 1394 | 2251426 | [
"23727313",
"10670430",
"12652963",
"13964633"
] | scientific_claim_retrieval | scientific |
62b3766333a6cc1cb211e418238f75a5 | mteb/scifact | Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events. | Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.. BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit... | [
"Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.. Angiotensin converting enzyme (ACE) inhibitors are now one ... | 342 | 5884524 | [
"6157837",
"471921",
"308862",
"15648443"
] | scientific_claim_retrieval | scientific |
6df94fe81b739115b35bd7fcc2339dc7 | mteb/scifact | Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs. | eRNAs are required for p53-dependent enhancer activity and gene transcription.. Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we describe bi... | [
"Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ. BACKGROUND Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer... | 177 | 9669099 | [
"3590806",
"38919140",
"23985464",
"21557055"
] | scientific_claim_retrieval | scientific |
12d57fe7fcf4ac8033a778c1c76b43ca | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions. Activation and regulation of the cascade systems of the blood (the complement system, the coagulation/contact activation/kallikrein system, and the fibrinolytic system) occurs via activation of zymogen molec... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | ieb5ec5j | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
6625e87cfb99f0db33b36312e23fee8b | mteb/scifact | 7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults. | Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age. Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and mem... | [
"Economic implications of nighttime attending intensivist coverage in a medical intensive care unit.. OBJECTIVE Our objective was to assess the cost implications of changing the intensive care unit staffing model from on-demand presence to mandatory 24-hr in-house critical care specialist presence. DESIGN A pre-pos... | 20 | 3202143 | [
"40905302",
"41340212",
"24273592",
"9254550"
] | scientific_claim_retrieval | scientific |
69f9f02ffbde4c55f416030fc3002f2e | mteb/scifact | Pyridostatin stabilizes the G - quadruplex in the telomeric region. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei.. Most eukaryotic telomeres contain a repeating motif with stretches of guanine residues that form a 3'-terminal overhang extending beyond the telomeric duplex region. The telomeric repeat of hypot... | 1000 | 16472469 | [
"25842866",
"1583134",
"3033830",
"19487477"
] | scientific_claim_retrieval | scientific |
495b2200ed5f880e705e4603081029fc | mteb/scifact | Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR). | Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functi... | [
"Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.. Mammalian DNA polymerase mu (pol mu) is related to terminal deoxynucleotidyl transferase, but its biological role is not yet clear. We show here that after exposure of cells to ionizing radi... | 777 | 32275758 | [
"27635177",
"11569583",
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"6536598"
] | scientific_claim_retrieval | scientific |
b1e01869420ce5bfb6c3b0a5df6d8bd3 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics. Studies using human genetics have identified more than 160 loci that affect the risk of developing inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Several of these genes ... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 6xgy0cm3 | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
63336787373265bfb1648651b1da658c | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | Emergency Triage of Highly Infectious Diseases and Bioterrorism. Emergency medical services are a key element in health systems for the evaluation and treatment of patients exposed to highly infectious diseases or bioterrorism agents. Triage and early identification at any point of care can have a significant impact on... | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | fz48wydz | [
"jzlouns7",
"jc443w2a",
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"0smru5k2"
] | biomedical_literature_retrieval | scientific |
d6b451abd1676c9c1abb8a7c3ac7b1f3 | mteb/scifact | Upregulation of PD1 causes the upregulation of Satb1. | SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells. &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT‐rich sequence‐binding p... | [
"PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Leukemias and other cancers possess self-renewing stem cells that help to maintain the cancer. Cancer stem cell eradication is thought to be crucial for successful anticancer therapy. Using an acute myeloid leukemi... | 1350 | 5377642 | [
"8764879",
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"3870062"
] | scientific_claim_retrieval | scientific |
d5b2183cc8e26c6eb63a9b6e9b13193c | mteb/scifact | During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks. | The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining. Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined. We sought to address this question ... | [
"Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.. Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic ... | 357 | 18111172 | [
"20821402",
"12552297",
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] | scientific_claim_retrieval | scientific |
5b11f9f89d38aa692a43dcd95c9dd706 | mteb/scifact | The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat. | Tracking adipogenesis during white adipose tissue development, expansion and regeneration. White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HF... | [
"Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity.. Adipose tissue exerts important endocrine and metabolic functions in health and disease. Yet the bioenergetics of this tissue is not characterized in humans and possible regional differences are not elucidated... | 1193 | 20532591 | [
"39187170",
"23017040",
"42465769",
"32955023"
] | scientific_claim_retrieval | scientific |
2d3f7590a35bd04cb6bfcee209dacf58 | mteb/scifact | Piezo1 channels are sensors for cell migration in epithelial cells. | Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro. Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility. Recently, we screened Piezo1 as a candidate TFF1-binding protein. We aimed t... | [
"Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes. BACKGROUND Carbon nanotubes (CNT) hold great promise to create new and better products for commercial and biomedical applications, but their long-term adverse health effects ... | 951 | 21414718 | [
"16532419",
"6308416",
"3118719",
"26047921"
] | scientific_claim_retrieval | scientific |
2f5f84f0765791ed55e76f483c02f036 | mteb/scifact | Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors. | ARID1A-mutated ovarian cancers depend on HDAC6 activity. ARID1A, encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this gene... | [
"Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium. Bacterial pathogens produce complex carbohydrate capsules to protect against bactericidal immune molecules. Paradoxically, the pneumococcal capsule sensitizes the bacterium to antimicrobial peptides found on epithe... | 631 | 5468807 | [
"1234098",
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"7165938",
"3173489"
] | scientific_claim_retrieval | scientific |
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