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### Instruction:
why can you not take grapefruit with felodipine
### Response:
Drinking grapefruit juice while taking Felodipine (Plendil), a medication for high blood pressure might cause your blood pressure to go too low, because grapefruit juice might increase how much Felodipine the body absorbs.
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| Grapefruit Bioflavonoid Complex Bioflavonoid Concentrate Bioflavonoid Extract Bioflavonoids Bioflavonoïdes Bioflavonoïdes d'grumes Citrus Bioflavones Citrus Bioflavonoid Citrus Bioflavonoid Extract Citrus Bioflavonoids Citrus Flavones Citrus Flavonoids Citrus Grandis Extract Citrus paradisi Citrus Seed Extract Cold-Pr... |
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Glycyrrhetinic acid is a substance that is naturally present in licorice, a plant used for medicinal and culinary purposes. It has been found to have a range of biological activities, including the ability to block the activity of the enzyme 11β-hydroxyste... | What is glycyrrhetinic acid and where is it found? How does it affect the activity of the enzyme 11β-hydroxysteroid dehydrogenase? |
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Answer this question truthfully
### Response:
Ursodiol primarily works in Primary Biliary Cholangitis by protecting hepatocytes against apoptosis. It does so by reducing the toxic effects of hydrophobic bile acids on liver cells, which can trigger cell death. Ursodiol also has immunomodulatory effects... | What is the mechanism of action of Ursodiol in treating Primary Biliary Cholangitis and how does it protect hepatocytes? |
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Answer this question truthfully
### Response:
The chemical formula is RCOO- CH 2 CH (-OOCR') CH 2 -OOCR", where R, R', and R" are longer alkyl chains. The three fatty acids RCOOH, R'COOH and R"COOH can be all different, all the same, or only two the same.
Chain lengths of the fatty acids in naturally ... | What is the role of biochemistry in relation to triglycerides? |
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Answer this question truthfully
### Response:
It is a hypersensitivity to dietary substances from soy causing an overreaction of the immune system which may lead to severe physical symptoms for millions of people.
Many fast-food restaurants commonly use soy protein in hamburger buns (soy flour) hambu... | What does a soy allergy mean? |
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Answer this question truthfully
### Response:
Troxerutin is a flavonol, a type of flavonoid. It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the Japanese pagoda tree
It is used as a vasoprotective. Troxerutin has been shown in mice to reverse CNS insulin resista... | What is Troxerutin and can you provide an overview of it? |
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Answer this question truthfully
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After a program of high-throughput screening of a class of drugs targeting the first step, the farnesyltransferase inhibitors (FTIs) were developed (Reuter et al., 2000). A number of molecules were found to have FTI activity. Some earlier compounds were fo... | What is a substance that inhibits Farnesyltransferase? |
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Answer this question truthfully
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Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant that functions as a functional vitamin K depleter (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases.
... | What is dicumarol, and can you provide an overview of it? |
### Instruction:
Please answer with one of the option in the bracket
### Response:
B: Acidic pH, co-administration of antioxidant A, no administration of drug B
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| Q:A drug discovery team is conducting research to observe the characteristics of a novel drug under different experimental conditions. The drug is converted into the inactive metabolites by an action of an enzyme E. After multiple experiments, the team concludes that as compared to physiologic pH, the affinity of the e... |
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Please answer with one of the option in the bracket
### Response:
E: Covalent bonds between carboxyl and amino groups
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| Q:Researchers are investigating the effects of an Amazonian plant extract as a novel therapy for certain types of tumors. When applied to tumor cells in culture, the extract causes widespread endoplasmic reticulum stress and subsequent cell death. Further experiments show that the extract acts on an important member of... |
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Please answer with one of the option in the bracket
### Response:
A: 0.04
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| Q:An investigator is studying the efficacy of preventative measures to reduce pesticide poisonings among Central American farmers. The investigator evaluates the effect of a ban on aldicarb, an especially neurotoxic pesticide of the carbamate class. The ban aims to reduce pesticide poisonings attributable to carbamates... |
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Please answer with one of the option in the bracket
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B: Fatty acids with double bonds in the 3rd position adjacent to the terminal carbon are cardioprotective against the effects of IL-1β in post-MI cells.
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| Q:A researcher is investigating the relationship between inflammatory mediators and omega-3 fatty acids, namely docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in post-MI patients. IL-1ß is an important pro-inflammatory cytokine involved in fibrosis and arrhythmias in the post-MI period. Research indicates ... |
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Question: is this a 2) strong advice, 1) weak advice 0) no advice?
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This is no advice
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| Although we did not measure miRNA expression levels by lutein/zeaxanthin intake, our study supports the notion that dietary lutein/zeaxanthin intake impacts DICER1 activity by regulating miRNA expression, thus affecting CRC risk via an underlying interaction between antioxidant effects and miRNA expression. |
### Instruction:
Question: is this a 2) strong advice, 1) weak advice 0) no advice?
### Response:
This is no advice
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| Interestingly, 4-day feeding of doxycycline chow in DT (podocyte-specific constitutively active Nfatc1nuc) mice is characterized by altered cholesterol homeostasis, podocyte foot process effacement, and albuminuria that can be partially prevented by cholesterol depletion (Figure 8). |
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Please summerize the given abstract to a title
### Response:
Clinical practice guidelines for the treatment of allergic rhinitis in children with traditional Chinese medicine.
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| Allergic rhinitis (AR) is one of the most common allergic diseases in children and it can lead to physical and mental health problems. Traditional Chinese medicine (TCM) plays an important role in understanding the phenotypes and treatment of AR. However, there are currently no normative clinical practice guidelines (C... |
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Please summerize the given abstract to a title
### Response:
Troxerutin exerts neuroprotection against lipopolysaccharide (LPS) induced oxidative stress and neuroinflammation through targeting SIRT1/SIRT3 signaling pathway.
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| This study was conducted to clarify the potential mechanisms of Troxerutin neuroprotection against Lipopolysaccharide (LPS) induced oxidative stress and neuroinflammation through targeting the SIRT1/SIRT3 signaling pathway. To establish a model, a single dose of LPS (500μg/kg body weight) was injected to male Wistar ra... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Development of Carrot Nutraceutical Products as an Alternative Supplement for the Prevention of Nutritional Diseases
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| Nutraceuticals can serve as an alternative supplement to overcome nutritional deficiency for a healthy lifestyle. They can also play a key role in disease management. To develop carrot nutraceutical products, 64 genotypes from four different continents were evaluated for a range of morpho-nutrition variables. Genetic v... |
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Please summerize the given abstract to a title
### Response:
Ingredients such as trehalose and hesperidin taken as supplements or foods reverse alterations in human T cells, reducing asbestos exposure-induced antitumor immunity
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| Exposure of human immune cells to asbestos causes a reduction in antitumor immunity. The present study aimed to investigate the recovery of reduced antitumor immunity by several ingredients taken as supplements or foods, including trehalose (Treh) and glycosylated hesperidin (gHesp). Peripheral blood CD4(+) cells were ... |
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Please summerize the given abstract to a title
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Global thrombosis test for assessing thrombotic status and efficacy of antithrombotic diet and other conditions
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| Because of the high mortality from myocardial infarction and stroke, there is a great demand for finding novel methods of diagnosis, prevention and treatment of these diseases. Most of the current tests measure important determinants of thrombosis such as platelet function, coagulation and fibrinolysis in isolation; th... |
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Please summerize the given abstract to a title
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Comparative Evaluation of the Antimicrobial and Mucus Induction Properties of Selected Bacillus Strains against Enterotoxigenic Escherichia coli
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| Probiotics have been shown to bind to host receptors, which are important for pathogen adhesion and induce the host’s production of defence factors. They can activate the goblet-cell-derived production of mucins, a major component of the mucus layer and a physical barrier participating in limiting the proximity of micr... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Impact of Cannabinoid Compounds on Skin Cancer
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| SIMPLE SUMMARY: Recent research has suggested that the endocannabinoid system offers several pharmacotherapeutic targets for drug administration as new options for the treatment and prophylaxis of skin cancer. This review focused on the anticarcinogenic mechanisms of cannabinoids at the different levels of skin cancer ... |
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Please summerize the given abstract to a title
### Response:
Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells
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| Calcitriol, a vitamin D(3) metabolite, is approved for various indications because it is the bioactive form of vitamin D in the body. The purpose of this study was to predict the clinical significance of cytochrome P450 (CYP) induction by calcitriol using in vitro human cryopreserved hepatocytes, HepaRG experimental sy... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Temporal patterns of tramadol in hair after a single dose
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| This controlled study aimed to measure concentrations of tramadol (TRA) and its two main metabolites, N-desmethyltramadol (NDMT) and O-desmethyltramadol (ODMT), in hair following a single dose ingestion and to investigate the distribution patterns in hair by segmental analysis of hair samples taken at several sampling ... |
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Please summerize the given abstract to a title
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Correction: Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice
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| Correction for 'Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice' by Meihuan Zhao et al., Food Funct., 2021, DOI: 10.1039/D1FO00876E. |
### Instruction:
Please summerize the given abstract to a title
### Response:
Evaluation of promotion of iron-rich foods for the prevention of nutritional anemia in India.
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| Background Nutritional anemia due to iron deficiency is the most common cause of anemia in India. The average diet in India is low in iron and mostly of vegetable origin. This can be improved by increasing awareness of foodstuffs that are rich in iron and ensuring their availability. Objective The objective of the stud... |
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Please summerize the given abstract to a title
### Response:
Evaluation of the Health-Promoting Properties of Selected Fruits
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| In this study, the health-promoting benefits of different fruits grown in Madeira Island, namely lemon (Citrus limon var. eureka), tangerine (Citrus reticulata var. setubalense), pitanga (Eugenia uniflora var. red), tomato (Solanum lycopersicum var. gordal) and uva-da-serra, an endemic blueberry (Vaccinium padifolium S... |
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### Response:
Structural Characterization and Immunomodulatory Activity of a Novel Polysaccharide From Lycopi Herba
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| Lycopi Herba has been broadly used as a traditional medicinal herb in Asia due to its ability to strengthen immunity. However, it is still obscure for its material basis and underlying mechanisms. Polysaccharide, as one of the most important components of most natural herbs, usually contributes to the immunomodulatory ... |
### Instruction:
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### Response:
Curcuma longa L. Water Extract Enhances Endurance Exercise Capacity by Promoting Intramuscular Mitochondrial Biogenesis in Mice
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| We investigated the effect of Curcuma longa L. extract on endurance exercise capacity (EEC). EEC is the ability to exercise continuously and recover quickly, even when tired. C. longa contains antioxidants that contribute beneficial effects on the body. We separated groups of nonexercise (CON), exercise control (Ex-CON... |
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### Response:
First Discovery of Acetone Extract from Cottonseed Oil Sludge as a Novel Antiviral Agent against Plant Viruses
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| A novel acetone extract from cottonseed oil sludge was firstly discovered against plant viruses including Tobacco mosaic virus (TMV), Rice stripe virus (RSV) and Southern rice black streaked dwarf virus (SRBSDV). Gossypol and β-sitosterol separated from the acetone extract were tested for their effects on anti-TMV and ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver
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| BACKGROUND AND AIMS: Nanoparticles could represent a therapeutic approach for the treatment of various diseases. It has been reported that cerium oxide nanoparticles (CeO(2) NPs) have potential useful effects. Therefore, we aimed to examine the protective effects of the CeO(2) NPs in two models of liver injury, non-alc... |
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Please summerize the given abstract to a title
### Response:
Anti-inflammatory and analgesic activities of indigo through regulating the IKKß/IκB/NF-κB pathway in mice
### Response:
| This study investigated the anti-inflammatory and analgesic activities of indigo in mice and explored the possible related mechanisms. Xylene-induced ear edema, carrageenan-induced paw edema, and acetic acid-induced vascular permeability tests were used in investigating the anti-inflammatory activities. The anti-nocice... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats
### Response:
| The antimalarial agent mefloquine is currently being investigated for its potential to inhibit feline coronavirus and feline calicivirus infections. A simple, high pressure liquid chromatography assay was developed to detect mefloquine plasma concentrations in feline plasma. The assay's lower limit of quantification wa... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Non-Lethal Intoxication by Ingestion of 50 Castor Beans: Serial Measurement of Ricinine in Blood, Plasma, and Urine.
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| A 30-year-old woman presented to the emergency department 2 days after ingestion of 50 castor beans. Her symptoms on admission were vomiting, diarrhea, abdominal cramps, agitation and anxiety. Initial laboratory tests showed a slightly elevated C-reactive protein (CRP) and mild liver and kidney dysfunction The patient ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected cats
### Response:
| The antimalarial agent mefloquine is currently being investigated for its potential to inhibit feline coronavirus and feline calicivirus infections. A simple, high pressure liquid chromatography assay was developed to detect mefloquine plasma concentrations in feline plasma. The assay's lower limit of quantification wa... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Hydrophilic prodrug approach for reduced pigment binding and enhanced transscleral retinal delivery of celecoxib.
### Response:
| Transscleral retinal delivery of celecoxib, an anti-inflammatory and anti-VEGF agent, is restricted by its poor solubility and binding to the melanin pigment in choroid-RPE. The purpose of this study was to develop soluble prodrugs of celecoxib with reduced pigment binding and enhanced retinal delivery. Three hydrophil... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Omega-3 Polyunsaturated Fatty Acids EPA and DHA as an Adjunct to Non-Surgical Treatment of Periodontitis: A Randomized Clinical Trial
### Response:
| Periodontitis is a chronic multifactorial inflammatory disease that leads to the loss of supportive tissues around the teeth with gradual deterioration of masticatory function and esthetics, resulting eventually in the decrease of the life quality. Host immune response triggered by bacterial biofilm is responsible for ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Application of Pomegranate by-Products in Muscle Foods: Oxidative Indices, Colour Stability, Shelf Life and Health Benefits
### Response:
| In recent years, considerable importance is given to the use of agrifood wastes as they contain several groups of substances that are useful for development of functional foods. As muscle foods are prone to lipid and protein oxidation and perishable in nature, the industry is in constant search of synthetic free additi... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Antiviral Substances in Raw Bovine Milk Active Against Bovine Rotavirus and Coronavirus.
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| After experimental contamination of bovine raw and heat-treated milks with bovine rotavirus and coronavirus strains, we observed a strong viral inhibition only with raw milks, from which virus recovery was 5 × 10-4%. Between 30% and 80% of the virus was recovered from the heat-treated milks, depending on the level of i... |
### Instruction:
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### Response:
Slime molds as a valuable source of antimicrobial agents
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| Given the emerging multidrug-resistant pathogens, the number of effective antimicrobial agents to deal with the threat of bacterial and fungal resistance has fallen dramatically. Therefore, the critical solution to deal with the missing effective antibiotics is to research new sources or new synthetic antibiotics. Natu... |
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### Response:
The Interplay of Ascorbic Acid with Quinones-Chelators—Influence on Lipid Peroxidation: Insight into Anticancer Activity
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| Ascorbic acid is a multifaceted compound that can perform both antioxidant and pro-oxidant activities in the redox reactions induced by transition metal ions, so its role in nature and especially in the human body is still the subject of debate. In the present study, we have examined the influence of ascorbic acid on l... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives
### Response:
| Essential oils (EOs) are volatile and concentrated liquids extracted from different parts of plants. Bioactive compounds found in EOs, especially terpenes and terpenoids possess a wide range of biological activities including anticancer, antimicrobial, anti-inflammatory, antioxidant, and antiallergic. Available literat... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Echinacea purpurea therapy for the treatment of the common cold: a randomized, double-blind, placebo-controlled clinical trial.
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| BACKGROUND Echinacea purpurea stimulates the immune response and is promoted to reduce symptom severity and the duration of upper respiratory tract infections. We sought to determine the efficacy of a standardized preparation of E purpurea in reducing symptom severity and duration of the common cold. METHODS A randomiz... |
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### Response:
Características Microbiológicas De Leite Integral E Bebida Láctea Processados Por Uat (ultra Alta Temperatura) Ao Longo Do Período De Validade
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| ABSTRACT UHT milk and dairy drinks are submitted to the same heat treatment, but they are different products, since the addition of up to 50% of whey is allowed in dairy drinks. The aim of this study was to evaluate the microbiological characteristics of these products in relation to current legislation, during the cou... |
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Please summerize the given abstract to a title
### Response:
EPA's pleiotropic mechanisms of action: a narrative review.
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| Treatment with icosapent ethyl 4 g/day, a highly purified and stable ethyl ester of eicosapentaenoic acid (EPA), demonstrated a significant reduction in atherosclerotic cardiovascular disease (ASCVD) events and death in REDUCE-IT. However, analyses of REDUCE-IT and meta-analyses have suggested that this clinical benefi... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Key parameter optimization using multivariable linear model for the evaluation of the in vitro estrogenic activity assay in T47D cell lines (CXCL-test)
### Response:
| In comparison to analytical tools, bioassays provide higher sensitivity and more complex evaluation of environmental samples and are indispensable tools for monitoring increasing in anthropogenic pollution. Nevertheless, the disadvantage in cellular assays stems from the material variability used within the assays, and... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Baicalein Reduces Airway Injury in Allergen and IL-13 Induced Airway Inflammation
### Response:
| BACKGROUND: Baicalein, a bioflavone present in the dry roots of Scutellaria baicalensis Georgi, is known to reduce eotaxin production in human fibroblasts. However, there are no reports of its anti-asthma activity or its effect on airway injury. METHODOLOGY/PRINCIPAL FINDINGS: In a standard experimental asthma model, m... |
### Instruction:
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### Response:
Assessment of the Diversity of Medico-Magic Knowledge on Four Herbaceous Species in Benin.
### Response:
| Background Ethnobotanical knowledge on four herbaceous species, Acmella uliginosa (Sw.) Cass., Momordica charantia L., Phyllanthus amarus Schumach. & Thonn., and Scoparia dulcis L., in Benin was investigated. Methods Herbal medicine traders in six different markets were interviewed using a semi-structured questionnaire... |
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Please summerize the given abstract to a title
### Response:
12 Advances in Cancer Chemotherapeutic Drug Research in China
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| In this chapter, the history of cancer chemotherapy discipline in China is briefly reviewed. Some effective antitumor drugs discovered in China are introduced such as Gengshengmeisu (actinomycin K), hydroxycamptothecin, homoharringtonine, methoxysarcolysin, N-formyl sarcolysin, nitrocaphane, glyciphosphoramide, bimolan... |
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Please summerize the given abstract to a title
### Response:
Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m‐chlorophenylpiperazine in the horse
### Response:
| Trazodone is a serotonin receptor antagonist and reuptake inhibitor used extensively as an anxiolytic in human and small animal veterinary medicine. The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of oral trazodone in clinical horses. Six... |
### Instruction:
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### Response:
Levamisole - A Toxic Adulterant in Illicit Drug Preparations: A Review.
### Response:
| Discovered in the 1960s, the common anthelminthic levamisole has seen widespread use in veterinary applications. Its use rapidly expanded thereafter to include human medical treatments for a variety of acute and chronic disorders. Due to reports of severe adverse effects, the US Food and Drug Administration withdrew le... |
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### Response:
Chronic Intestinal Disorders in Humans and Pets: Current Management and the Potential of Nutraceutical Antioxidants as Alternatives
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| SIMPLE SUMMARY: Chronic disorders of the intestinal tract (CID) are characterized by signs of inflammation of the intestine for a period of at least three weeks. Both humans and pets can be affected by these disorders. Different therapeutic approaches can be selected to treat patients and the use of natural products ha... |
### Instruction:
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### Response:
Synergistic Activity of Minocycline and Rifampin in Combination with Antifungal Drugs against Candida auris
### Response:
| Candida auris is an emerging multidrug-resistant fungal pathogen that spreads readily in healthcare settings and has caused numerous hospital outbreaks. Very few treatment options exist for C. auris infections. We evaluated the activity of all two-drug combinations of three antifungal agents (amphotericin B, caspofungi... |
### Instruction:
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### Response:
Phylloseptin-1 is Leishmanicidal for Amastigotes of Leishmania amazonensis Inside Infected Macrophages.
### Response:
| Leishmania protozoans are the causal agents of neglected diseases that represent an important public health issue worldwide. The growing occurrence of drug-resistant strains of Leishmania and severe side effects of available treatments represent an important challenge for the leishmaniases treatment. We have previously... |
### Instruction:
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### Response:
Chitosan oligosaccharide ameliorated obesity by reducing endoplasmic reticulum stress in diet-induced obese rats
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| OBJECTIVE: This study aimed to determine whether chitosan oligosaccharide (COST) improves overweight by reducing endoplasmic reticulum (ER) stress in the liver and liver cancer cells. METHODS: An obesity model was established by feeding Sprague-Dawley rats (ORs) a high-fat diet (HFD) and treating them with COST for 8 w... |
### Instruction:
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### Response:
Inhibitory effects of four active components in saffron on human ether-a-go-go-related gene (hERG) K+ currents.
### Response:
| The main active components of saffron are crocin, crocetin, picrocrocin, and safranal. There are many studies on their cardioprotective effects, but their cardiotoxicities have not been reported. The human ether-a-go-go-related gene (hERG) K+ channels are of considerable pharmaceutical interest as the target responsibl... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Aflatoxin Contamination, Its Impact and Management Strategies: An Updated Review
### Response:
| Aflatoxin, a type of mycotoxin, is mostly produced by Aspergillus flavus and Aspergillus parasiticus. It is responsible for the loss of billions of dollars to the world economy, by contaminating different crops such as cotton, groundnut, maize, and chilies, and causing immense effects on the health of humans and animal... |
### Instruction:
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### Response:
Effects of inhalation exposure to a high-boiling (288 to 454°C) coal liquid
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| Abstract Coal liquids have been evaluated in a variety of short-term toxicological assays; however, few studies have been conducted to determine the systemic effects after inhalation exposure to these materials. To extend the data base on potential health effects from coal liquefaction materials, we performed a study w... |
### Instruction:
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### Response:
Critical roles of platelets in lipopolysaccharide-induced lethality: effects of glycyrrhizin and possible strategy for acute respiratory distress syndrome
### Response:
| Within a few minutes of an intravenous injection of a lipopolysaccharide (LPS) into mice, platelets accumulate, largely in the lung. At higher doses, LPS induces rapid shock (within 10 min), leading to death within 1 h. This type of shock differs from so-called endotoxin shock, in which shock signs and death occur seve... |
### Instruction:
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### Response:
ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats.
### Response:
| This study investigates the effect of ACE2 activation on leptin-induced changes in systolic blood pressure (SBP), proteinuria, endothelial activation and ACE2 expression during pregnancy in Sprague-Dawley rats. Pregnant rats were given subcutaneous injection of either saline, or leptin, or leptin plus xanthenone (ACE2 ... |
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### Response:
The protective effect of rosmarinic acid on myotube formation during myoblast differentiation under heat stress
### Response:
| High ambient temperature is one of the most important environmental factors that caused the reduction of livestock productivity and the increase of mortality. It has been shown that heat stress could affect the meat quality characteristics by physiological and metabolic perturbations in live livestock. Rosmarinic acid ... |
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### Response:
Alginate nanocomposite biofilms containing sepiolite modified with polyphenols from myrtle berries extract.
### Response:
| Alginate nanocomposite films incorporating sepiolite (Sep) modified with myrtle berries extract (MBE) rich in polyphenols were prepared by solution casting method. The effects of different extract concentrations on the film properties were determined by measuring physicochemical, mechanical and antioxidant properties o... |
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### Response:
Ethnobotanical and ethnomedicinal analysis of wild medicinal plants traditionally used in Naâma, southwest Algeria
### Response:
| Algerian people largely rely on traditional medicine practices as part of a community’s identity. This first ethnobotanical study aimed to quantify and document the wild medicinal plant taxa from four family and the related traditional knowledge in Naâma province, Algeria. The survey was carried out between 2018 and 20... |
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### Response:
Antioxidants other than vitamin C may be detected by glucose meters: Immediate relevance for patients with disorders targeted by antioxidant therapies
### Response:
| Owing to their ease of use, glucose meters are frequently used in research and medicine. However, little is known of whether other non-glucose molecules, besides vitamin C, interfere with glucometry. Therefore, we sought to determine whether other antioxidants might behave like vitamin C in causing falsely elevated blo... |
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### Response:
Chitin derivatives ameliorate DSS-induced ulcerative colitis by changing gut microbiota and restoring intestinal barrier function
### Response:
| Chitin derivatives (CDs), including chitosan (CS), chitooligosaccharides (COS), and glucosamine (GlcN), were administrated in dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) mice. UC symptoms such as body weight loss, reduced food intake, and increased disease activity index were relieved (except GlcNL gro... |
### Instruction:
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### Response:
Purification of rutin by supercritical fluid simulated moving bed chromatography
### Response:
| Recent studies have shown that rutin (Quercetin-3-O-rhamnosylglucoside) may have an inhibitory effect on COVID-19. Rutin can be extracted from Tartary buckwheat as an active pharmaceutical ingredient. Nevertheless, its purification is mainly hindered by Kaempferol-3-O-rutinoside (K3R) due to their similar molecular str... |
### Instruction:
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### Response:
Supplementing cultured human myotubes with hibernating bear serum results in increased protein content by modulating Akt/FOXO3a signaling
### Response:
| Hibernating bears remain in their dens for 5-7 months during winter and survive without eating or drinking while staying inactive. However, they maintain their physical functions with minimal skeletal muscle atrophy and metabolic dysfunction. In bears, resistance to skeletal muscle atrophy during hibernation is likely ... |
### Instruction:
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### Response:
Opportunities for Health Promotion: Highlighting Herbs and Spices to Improve Immune Support and Well-being
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| Context: Consuming a balanced and varied diet is beneficial for health, especially when individuals feel stressed, scared, insecure, unequipped, or disempowered from maintaining their health during the COVID-19 pandemic Nutrient deficiencies from inadequate intake of healthful foods can contribute to a weakened immune ... |
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### Response:
The effect of low ascorbic acid content on tomato fruit ripening.
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| MAIN CONCLUSION The oxidant/antioxidant balance affects the ripening time of tomato fruit. Ripening of tomato fruit is associated with several modifications such as loss of cell wall firmness and transformation of chloroplasts to chromoplasts. Besides a peak in H2O2, reactive oxygen species (ROS) are observed at the tr... |
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Anti-inflammatory and In Silico Docking Studies of Heterophragma adenophyllum Seem Stem Constituents
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| Heterophragma adenophyllum is a traditional medicinal plant that has been used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflamma... |
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Lychee Biology and Biotechnology
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| Lychee (Litchi chinensis Sonn.) is one of the revered members of the soapberry family Sapindaceae which includes 150 genera and 2000 species. It is a tropical and subtropical fruit tree which is native to Fujian and Guangdong regions of China and is cultivated as an important commercial fruit crop in many parts of the ... |
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PEGylated human catalase elicits potent therapeutic effects on H1N1 influenza-induced pneumonia in mice
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| Therapeutic recombinant human catalase (rhCAT) can quench infection-induced reactive oxygen species (ROS), thereby alleviating the associated tissue damage. Although the intranasal route is efficient to deliver native rhCAT to the lung, the therapeutic effect is limited by rapid elimination from the blood. In this stud... |
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Candida albicans Genotyping and Relationship of Virulence Factors with Fluconazole Tolerance in Infected Pediatric Patients
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| Purpose: Candida albicans of different genotypes is a common cause of fungal infection in pediatric setting. This cross sectional study was designed to investigate ABC genotypes and the relationship between virulence factors and fluconazole tolerance among C. albicans isolates from infected pediatric patients. Material... |
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Immunomodulatory properties of triterpenes
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| The immune system is one of the main defence mechanisms of the human body. Inadequacy of this system or immunodeficiency results in increased risk of infections and tumours, whereas over-activation of the immune system causes allergic or autoimmune disorders. A well-balanced immune system is important for protection an... |
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Green Tea Suppresses Brain Aging
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| Epidemiological studies have demonstrated that the intake of green tea is effective in reducing the risk of dementia. The most important component of green tea is epigallocatechin gallate (EGCG). Both EGCG and epigallocatechin (EGC) have been suggested to cross the blood–brain barrier to reach the brain parenchyma, but... |
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Review on potential antiviral and immunomodulatory properties of Piper Longum
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| Piper longum traditionally known as Pippali is a climbing vine belonging to the Piperaceae family, which originated in northeastern India and the Western Ghats. It is majorly used in traditional and Ayurvedic system of medicines to treat bronchitis, diarrhea, viral hepatitis, respiratory infections, stomach pain, bronc... |
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Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens
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| BACKGROUND: The increasing number of multidrug-resistant bacteria and the fact of antibiotic resistance is leading to a continuous need for discovering alternative treatments against infections, e.g. in the case of respiratory tract diseases. Essential oils (EOs), because of their volatility, can easily reach both the ... |
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Two Candida auris Cases in Germany with No Recent Contact to Foreign Healthcare—Epidemiological and Microbiological Investigations
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| Candida auris has become a global fungal public health threat. This multidrug-resistant yeast is associated with nosocomial intra- and interhospital transmissions causing healthcare-associated infections. Here, we report on two C. auris cases from Germany. The two patients stayed in Germany for a long time before C. au... |
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Antiviral Properties of Phytochemicals
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| In recent years, significant progress has been achieved for the development of novel anti-viral drugs. These newly developed drugs belong to three groups of compounds, nucleoside analogues, thymidine kinase-dependent nucleotide analogues and specific viral enzyme inhibitors. It has been found that the natural products,... |
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Polyherbal formula (ASILACT®) induces Milk production in lactating rats through Upregulation of α-Lactalbumin and aquaporin expression
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| BACKGROUND: Polyherbal formula (PHF) contains extract of Sauropus androgynous (L.) Merr., Trigonella foenum-graceum L., and Moringa oleifera Lam. considered to induce galactagogue activity. This research aimed to evaluate the galactagogue activity of PHF and its effects on α-lactalbumin (LALBA) as well as aquapori... |
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Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID‐19 complications
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| COVID‐19 has become the focal point since 2019 after the outbreak of coronavirus disease. Many drugs are being tested and used to treat coronavirus infections; different kinds of vaccines are also introduced as preventive measure. Alternative therapeutics are as well incorporated into the health guidelines of some coun... |
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Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe Streptococcus suis Infections
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| Streptococcal toxic shock-like syndrome (STSLS) likely occurs when an individual is infected with the Streptococcus suis (S. suis) epidemic strain and is characterized by a cytokine storm, multiple organ dysfunction syndrome (MODS) and a high incidence of mortality despite adequate treatment. A number of antibiotics ex... |
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Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells
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| Acute pharyngitis is an inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues. Unsatisfactory treatment and repeated occurrences might cause chronic pharyngitis and other complications. Syringa oblata L. (S. oblata) is a traditional Chinese medicine that exhibited a significant therapeutic effec... |
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Interindividual Differences in In Vitro Human Intestinal Microbial Conversion of 3-Acetyl-DON and 15-Acetyl-DON
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| In order to evaluate the potential differences between 3-Ac-DON and 15-Ac-DON in the human intestinal microbial metabolism, human fecal samples were anaerobically cultured in vitro. Quantitative fecal microbiota characteristics were obtained by 16S rRNA sequencing, and the data revealed several genera that may be relev... |
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Modulatory Effects of Huoxiang Zhengqi Oral Liquid on Gut Microbiome Homeostasis Based on Healthy Adults and Antibiotic-Induced Gut Microbial Dysbiosis Mice Model
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| Traditional herbal medicine (THM) is used worldwide for its safety and effectiveness against various diseases. Huoxiang Zhengqi (HXZQ) is an extensively used Chinese THM formula targeting gastrointestinal disordered gastroenteritis via regulating the intestinal microbiome/immuno-microenvironment. However, the specific ... |
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Global metabolomic and lipidomic analysis reveals the potential mechanisms of hemolysis effect of Ophiopogonin D and Ophiopogonin D' in vivo
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| BACKGROUND: OPD and OPD' are the two main active components of Ophiopogon japonicas in Shenmai injection (SMI). Being isomers of each other, they are supposed to have similar pharmacological activities, but the actual situation is complicated. The difference of hemolytic behavior between OPD and OPD' in vivo and in vit... |
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Molecular Hydrogen: Is This a Viable New Treatment for Plants in the UK?
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| Despite being trialed in other regions of the world, the use of molecular hydrogen (H(2)) for enhanced plant growth and the postharvest storage of crops has yet to be widely accepted in the UK. The evidence that the treatment of plants and plant products with H(2) alleviates plant stress and slows crop senescence conti... |
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Medicines for Malaria Venture COVID Box: a source for repurposing drugs with antifungal activity against human pathogenic fungi
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| BACKGROUND: Treatment of mycoses is often ineffective, usually prolonged, and has some side effects. These facts highlight the importance of discovering new molecules to treat fungal infections. OBJECTIVES: To search the Medicines for Malaria Venture COVID Box for drugs with antifungal activity. METHODS: Fourteen human... |
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Ocorrência De Aspergillus Spp., Penicillium Spp. E Aflatoxinas Em Amostras De Farinha De Milho Utilizadas No Consumo Humano, Piauí, Brasil
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| ABSTRACT This study aimed to evaluate the presence of fungi and aflatoxin in a corn product intended for human consumption in the city of Teresina, Piauí, Brazil. Thirty corn flour samples (500 g) from six different trademarks were purchased from local supermarkets in the city of Piaui, Brazil, from January to March 20... |
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Evaluation of selected carotenoids of Lycopersicon esculentum variants as therapeutic targets for ‘Alzheimer’s disease: an in silico approach
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| The seriousness and menace of the worldwide weight of ‘Alzheimer’s disease have been related to a few factors, which incorporate antioxidant system depletion, mutation of proteins, and high expression of cholinesterases due to aging, environmental influence, diet, infectious agents, and hormonal imbalance. Overexpressi... |
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Morphology of Starch Particles along the Passage through the Gastrointestinal Tract in Laboratory Mice Fed Extruded and Pelleted Diets
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| Diet processing impacts on starch properties, such as the degree of starch gelatinization. This affects digestibility, as shown in laboratory mice fed either a pelleted or an extruded diet. In the present study, the morphology of starch particles throughout the digestive tract of mice was visualized. Thirty-two female ... |
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N ew C9-monoterpenoid Alkaloids Featuring a Rare Skeleton with Anti-inflammatory and Anti-viral Activities from Forsythia suspensa
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| Forsyqinlingines C ( 1 ) and D ( 2 ), two C 9 -monoterpenoid alkaloids bearing a rare skeleton, were isolated from the ripe fruits of Forsythia suspensa . Their structures, including absolute configurations, were fully elucidated by extensive spectroscopic data and ECD experiments. The plausible biogenetic pathway for ... |
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Chitosan elicitation of Isatis tinctoria L. hairy root cultures for enhancing flavonoid productivity and gene expression and related antioxidant activity
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| Elicitation for phytochemical enhancement via cost-effective elicitors can overcome the limitation of commercial application faced by plant cell and organ culture technology. Chitosan is a natural, low-cost, and nontoxic elicitor that can trigger plant defense responses with the concomitant enhancement in phytochemical... |
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Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox
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| Fungal infections impact the lives of at least 12 million people every year, killing over 1.5 million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven resistance in many serious fungal pathogens, and there is an urgent need to expand the current antifungal arsenal. Recent research has focu... |
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Herbal Phytomedicine 'Irisolidone' in chronic diseases: Biological Efficacy and pharmacological activity
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| BACKGROUND: Plant derived products have been used in the medicine as a source of bioactive molecules due to its therapeutic potential. Nowadays plants derived products have been used for the development of novel drug leads. Polyphenols are an important class of secondary metabolites found to be present in plant materia... |
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Formulation and efficacy evaluation of the safe and efficient moisturizing snow mushroom hand sanitizer
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| OBJECTIVES: Snow fungus or snow mushroom or white jelly mushroom (Tremella fuciformis), the edible mushroom, was formulated into hand sanitizer in form of moisturizing alcohol‐based hand rubs (ABHR) gel. METHODS: The stable base ABHRs were developed. The preferred bases were incorporated with various concentrations of ... |
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Relationship between food consumption and improvements in circulating melatonin in humans: an integrative review.
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| Melatonin is an important hormone in the regulation of circadian rhythms and has great antioxidant power. Recent studies have demonstrated the benefits of its supplementation in the metabolic profile. Food sources have also been studied for complementary therapies. However, information on the bioavailability of food so... |
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Fumonisin B2 Induces Mitochondrial Stress and Mitophagy in Human Embryonic Kidney (Hek293) Cells-A Preliminary Study
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| Ubiquitous soil fungi parasitise agricultural commodities and produce mycotoxins. Fumonisin B2 (FB2), the structural analogue of the commonly studied Fumonisin B1 (FB1), is a neglected mycotoxin produced by several Fusarium species. Mycotoxins are known for inducing toxicity via mitochondrial stress alluding to mitocho... |
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MLR-1023 Treatment in Mice and Humans Induces a Thermogenic Program, and Menthol Potentiates the Effect
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| A glucose-lowering medication that acts by a different mechanism than metformin, or other approved diabetes medications, can supplement monotherapies when patients fail to meet blood glucose goals. We examined the actions underlying the effects of an insulin sensitizer, tolimidone (MLR-1023) and investigated its effect... |
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Aronia melanocarpa Fruit Juice Modulates ACE2 Immunoexpression and Diminishes Age-Related Remodeling of Coronary Arteries in Rats
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| The aim of the study is to evaluate the effect of Aronia melanocarpa fruit juice (AMJ) supplementation on age-related coronary arteries remodeled in aged rat hearts. Male Wistar rats (n = 24) were divided into three groups: (1) young controls (CY), aged 2 months, without AMJ supplementation; (2) old controls (CO), aged... |
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