message stringlengths 4 10.2k | message_type stringclasses 3
values | message_id int64 0 2 | conversation_id int64 48.9k 898k | cluster float64 4 4 | __index_level_0__ int64 146k 2.69M |
|---|---|---|---|---|---|
Answer this question truthfully | instruction | 0 | 48,879 | 4 | 146,227 |
Angiotensin-converting enzyme 2 (ACE2), is a primary receptor for SARS-CoV-2 entry into cells, mostly presents in renal tubular epithelial cells as well as lungs and heart. Kidney injury following COVID-19 infection is less frequent than severe lung injury, however ACE2: ACE ratio is higher in the kidneys compared to ... | output | 1 | 48,879 | 4 | 146,228 |
What is the association between COVID-19 and acute kidney injury? | input | 2 | 48,879 | 4 | 146,229 |
Answer this question truthfully | instruction | 0 | 49,907 | 4 | 149,311 |
Angiotensin-converting enzyme 2 and Dipeptidyl peptidase have been implicated in the uptake of SARS-Cov and MERS-CoV Several studies have indicated that viral S-protein RBD interacts with host ACE2 receptor. S protein changes thus make the human cells permissive to SARS-CoV and SARS-CoV-2 infection ACE2: ACE ratio is h... | output | 1 | 49,907 | 4 | 149,312 |
What is the full form of GDS? | input | 2 | 49,907 | 4 | 149,313 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice? | instruction | 0 | 68,977 | 4 | 206,521 |
This is no advice | output | 1 | 68,977 | 4 | 206,522 |
The lung seems to be the target organ for SARS-CoV-2, and patients may develop acute lung injury and ARDS upon infection. | input | 2 | 68,977 | 4 | 206,523 |
Question: is this a 2) strong advice, 1) weak advice 0) no advice? | instruction | 0 | 71,454 | 4 | 213,952 |
This is no advice | output | 1 | 71,454 | 4 | 213,953 |
The tropism of SARS-CoV-2 for angiotensin converting enzyme 2 receptors expressed on endothelial cells seems to result in endothelial cell activation and apoptosis. | input | 2 | 71,454 | 4 | 213,954 |
Please summerize the given abstract to a title | instruction | 0 | 77,265 | 4 | 231,385 |
Murine-β-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2 | output | 1 | 77,265 | 4 | 231,386 |
The pandemic caused by SARS-CoV-2 has caused widespread infection and significant mortality across the globe Combined virology perspective of SARS-CoV-2 with a deep-rooted understanding of pathophysiological and immunological processes underlying the clinical manifestations of COVID-19 is of prime importance The charac... | input | 2 | 77,265 | 4 | 231,387 |
Please summerize the given abstract to a title | instruction | 0 | 77,337 | 4 | 231,601 |
Is Gut Involvement a Cause or Effect of COVID-19? | output | 1 | 77,337 | 4 | 231,602 |
Digestive disorder symptoms in COVID-19 may be similar in form to post-infectious functional gastrointestinal disorder (PI-FGID). To cause clinical effects, SARS-CoV-2 must reach the bowels and gastric hypochlorhydria may facilitate such transit. Asian elderly are predisposed to greater infection rate and severity of C... | input | 2 | 77,337 | 4 | 231,603 |
Please summerize the given abstract to a title | instruction | 0 | 77,412 | 4 | 231,826 |
Air contamination with SARS-CoV-2 in the operating room | output | 1 | 77,412 | 4 | 231,827 |
Angiotensin converting enzyme 2 (ACE2) is a target cell receptor for internalization and proliferation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). When ACE2-highly expressed tissues are manipulated, SARS-CoV-2 containing aerosols may be generated. Normal breathing and speaking are capable of pr... | input | 2 | 77,412 | 4 | 231,828 |
Please summerize the given abstract to a title | instruction | 0 | 77,436 | 4 | 231,898 |
Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging | output | 1 | 77,436 | 4 | 231,899 |
A 2018 report from the American Heart Association shows that over 103 million American adults have hypertension. The angiotensin-converting enzyme (ACE) (EC 3.4.15.1) is a dipeptidyl carboxylase that, when inhibited, can reduce blood pressure through the renin–angiotensin system. ACE inhibitors are used as a first-line... | input | 2 | 77,436 | 4 | 231,900 |
Please summerize the given abstract to a title | instruction | 0 | 77,925 | 4 | 233,365 |
An overview of preclinical animal models for SARS-CoV-2 pathogenicity | output | 1 | 77,925 | 4 | 233,366 |
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of fatalities globally since its origin in November 2019. The SARS-CoV-2 shares 79 and 50 per cent genome similarity with its predecessors, severe SARS-CoV and Middle East respiratory syndrome (MERS) coronavirus, all belonging to the same ge... | input | 2 | 77,925 | 4 | 233,367 |
Please summerize the given abstract to a title | instruction | 0 | 77,980 | 4 | 233,530 |
Potential pathogenesis of severe acute respiratory syndrome coronavirus 2 | output | 1 | 77,980 | 4 | 233,531 |
A review The emergence of novel coronavirus pneumonia which was named as coronavirus disease 2019 (COVID-19) by the World Health Organization, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to public health Notably, COVID-19 has rapidly spread around the world and lar... | input | 2 | 77,980 | 4 | 233,532 |
Please summerize the given abstract to a title | instruction | 0 | 77,998 | 4 | 233,584 |
Renin-angiotensin system blockers, risk of SARS-CoV-2 infection and outcomes fromCoViD-19: systematic review and meta-analysis | output | 1 | 77,998 | 4 | 233,585 |
AIMS: This meta-analysis provides summary odds ratio (OR) estimates for associations between treatment with (vs. without) renin-angiotensin system (RAS) blockers and risk of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection and coronavirus disease 2019 (CoViD-19) severity (including case-fatality) ... | input | 2 | 77,998 | 4 | 233,586 |
Please summerize the given abstract to a title | instruction | 0 | 78,035 | 4 | 233,695 |
Air pollution particulate matter as a potential carrier of SARS-CoV-2 to the nervous system and/or neurological symptom enhancer: arguments in favor | output | 1 | 78,035 | 4 | 233,696 |
Entry receptor for SARS-CoV-2 is expressed in nasal epithelial cells, and nasal delivery pathway can be a key feature of transmission. Here, a possibility of interaction of SARS-CoV-2 with air pollution particulate matter (PM) was considered. It was shown in our recent studies that water-suspended plastic and wood smok... | input | 2 | 78,035 | 4 | 233,697 |
Please summerize the given abstract to a title | instruction | 0 | 78,057 | 4 | 233,761 |
Role of Ecologic ACE I/D Polymorphism Data Towards Prediction of COVID-19 Epidemiology | output | 1 | 78,057 | 4 | 233,762 |
COVID-19 displays marked variability in the clinical course as well as regional epidemiology. Abnormalities in RAAS system especially stemming from genetic variability in ACE and ACE2 expression (including ACE I/D polymorphism) have been proposed to explain underlying pathogenesis and variability in SARS-CoV-2 infectio... | input | 2 | 78,057 | 4 | 233,763 |
Please summerize the given abstract to a title | instruction | 0 | 78,060 | 4 | 233,770 |
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids | output | 1 | 78,060 | 4 | 233,771 |
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells. We reasoned that differences in ACE2 or TMPRSS2 gene expression in sputum cell... | input | 2 | 78,060 | 4 | 233,772 |
Please summerize the given abstract to a title | instruction | 0 | 78,070 | 4 | 233,800 |
In vitro Characterisation of SARS-CoV-2 and Susceptibility of Domestic Ferrets (Mustela putorius furo). | output | 1 | 78,070 | 4 | 233,801 |
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emerging virus that has caused significant human morbidity and mortality since its detection in late 2019. With the rapid emergence has come an unprecedented programme of vaccine development with at least 300 candidates under development. Ferrets have p... | input | 2 | 78,070 | 4 | 233,802 |
Please summerize the given abstract to a title | instruction | 0 | 78,128 | 4 | 233,974 |
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases | output | 1 | 78,128 | 4 | 233,975 |
The rapid spread of the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought into focus the key role of angiotensin-converting enzyme 2 (ACE2), which serves as a cell surface receptor required for the virus to enter cells. SARS-CoV-2 can decrease cell surface ACE2 directly by int... | input | 2 | 78,128 | 4 | 233,976 |
Please summerize the given abstract to a title | instruction | 0 | 78,487 | 4 | 235,051 |
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung | output | 1 | 78,487 | 4 | 235,052 |
The continuous emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2) variants and the increasing number of breakthrough infection cases among vaccinated people support the urgent need for research and development of antiviral drugs. Viral entry is an intriguing target for antiviral drug development. We found... | input | 2 | 78,487 | 4 | 235,053 |
Please summerize the given abstract to a title | instruction | 0 | 78,509 | 4 | 235,117 |
Pathological Post Mortem Findings in Lungs Infected With Sars-Cov 2. | output | 1 | 78,509 | 4 | 235,118 |
Italy was the first European nation to be massively infected by SARS-COV 2. Up to the end of May 2020 more than thirty-three thousand deaths had been recorded in Italy with a large prevalence among males, those over 75 years of age, and in association with co-morbidities. We describe the lung pathological and immunohis... | input | 2 | 78,509 | 4 | 235,119 |
Please summerize the given abstract to a title | instruction | 0 | 78,589 | 4 | 235,357 |
17ß-Estradiol, a potential ally to alleviate SARS-CoV-2 infection | output | 1 | 78,589 | 4 | 235,358 |
Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as ... | input | 2 | 78,589 | 4 | 235,359 |
Please summerize the given abstract to a title | instruction | 0 | 78,590 | 4 | 235,360 |
Deceiving SARS-CoV-2 molecular-tropism clues - A combinational contemporary strategy | output | 1 | 78,590 | 4 | 235,361 |
Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specif... | input | 2 | 78,590 | 4 | 235,362 |
Please summerize the given abstract to a title | instruction | 0 | 78,797 | 4 | 235,981 |
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease | output | 1 | 78,797 | 4 | 235,982 |
The emergence of SARS-CoV-2 has created an international health crisis. Small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development. Mice are refractory to SARS-CoV-2 infection due to low affinity binding to the murine angiotensin-converting enzyme 2 (ACE2) protein.... | input | 2 | 78,797 | 4 | 235,983 |
Please summerize the given abstract to a title | instruction | 0 | 78,909 | 4 | 236,317 |
Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019 | output | 1 | 78,909 | 4 | 236,318 |
In the decades since the discovery of angiotensin-converting enzyme 2 (ACE2), its protective role in terms of antagonizing activation of the classical renin-angiotensin system (RAS) axis has been recognized in clinical and experimental studies on kidney and cardiovascular diseases. The effects of ACE inhibitor/angioten... | input | 2 | 78,909 | 4 | 236,319 |
Please summerize the given abstract to a title | instruction | 0 | 79,266 | 4 | 237,388 |
Effect of different human tissue processing techniques on SARS-CoV-2 inactivation-review | output | 1 | 79,266 | 4 | 237,389 |
The safety of the tissue transplant recipient is a top priority for tissue banks, and the emergence of the new coronavirus SARS-CoV-2 has raised significant concerns about the risks of releasing tissue for clinical use. In the present study, we conducted a literature review about the potential infectivity of SARS-CoV-2... | input | 2 | 79,266 | 4 | 237,390 |
Please summerize the given abstract to a title | instruction | 0 | 79,312 | 4 | 237,526 |
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model | output | 1 | 79,312 | 4 | 237,527 |
Understanding the host pathways that define susceptibility to SARS-CoV-2 infection and disease are essential for the design of new therapies. Oxygen levels in the microenvironment define the transcriptional landscape, however the influence of hypoxia on virus replication and disease in animal models is not well underst... | input | 2 | 79,312 | 4 | 237,528 |
Please summerize the given abstract to a title | instruction | 0 | 79,379 | 4 | 237,727 |
Mild and severe SARS-CoV-2 infection induces respiratory and intestinal microbiome changes in the K18-hACE2 transgenic mouse model | output | 1 | 79,379 | 4 | 237,728 |
Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and declining economies around the world. K18-hACE2 mice develop disease resembling severe SARS-CoV-2 infection in a virus dose-dependent manner. The relationship between SARS-CoV-2 and the intestinal or... | input | 2 | 79,379 | 4 | 237,729 |
Please summerize the given abstract to a title | instruction | 0 | 79,639 | 4 | 238,507 |
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease | output | 1 | 79,639 | 4 | 238,508 |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID-19). Here, through a genome-wide association study, we identify a variant (rs190509934, minor allele frequency 0.2–2%) that downregulates ACE2 expres... | input | 2 | 79,639 | 4 | 238,509 |
Please summerize the given abstract to a title | instruction | 0 | 79,664 | 4 | 238,582 |
A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors | output | 1 | 79,664 | 4 | 238,583 |
To predict the tropism of human coronaviruses, we profile 28 SCARFs using scRNA-seq data from a wide range of healthy human tissues. SCARFs include cellular factors both facilitating and restricting viral entry. Among adult organs, enterocytes and goblet cells of small intestine and colon, kidney proximal tubule cells,... | input | 2 | 79,664 | 4 | 238,584 |
Please summerize the given abstract to a title | instruction | 0 | 79,669 | 4 | 238,597 |
Ace2, Tmprss2 and Furin Gene Expression in the Airways of People with Asthma - Implications for Covid-19 | output | 1 | 79,669 | 4 | 238,598 |
To-date, there has not been a clear signal suggesting that asthma or treatment with inhaled steroids are a risk factor for severe COVID-19 disease We have therefore explored ACE2 receptor mRNA expression, and co-factors for Sars-CoV-2 infectivity (TMPRSS2 and furin) in bronchial brushes and biopsies from people with as... | input | 2 | 79,669 | 4 | 238,599 |
Please summerize the given abstract to a title | instruction | 0 | 79,787 | 4 | 238,951 |
Short‐term effects of COVID‐19 on semen parameters: A multicenter study of 69 cases | output | 1 | 79,787 | 4 | 238,952 |
OBJECTIVE: COVID‐19, which is known to be caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is a global health problem that can cause multiorgan damage because of its use of the angiotensin‐converting enzyme 2 (ACE2) receptor in its pathophysiology. We aimed to investigate whether SARS‐CoV‐2 had a... | input | 2 | 79,787 | 4 | 238,953 |
Please summerize the given abstract to a title | instruction | 0 | 79,799 | 4 | 238,987 |
The differences in SARS-CoV and SARS-CoV-2 specific co-expression network mediated biological process in human gut enterocytes | output | 1 | 79,799 | 4 | 238,988 |
Novel coronavirus SARS-CoV-2 was recently outbreak worldwide causes severe acute respiratory syndrome along with gastrointestinal symptoms for some infected patients. Information on detail pathogenesis, host immune responses and responsible biological pathways are limited. Therefore, infection specific host gut respons... | input | 2 | 79,799 | 4 | 238,989 |
Please summerize the given abstract to a title | instruction | 0 | 79,804 | 4 | 239,002 |
The Impact of Angiotensin Converting Enzyme Inhibition and/or Angiotensin Receptor Blockade on Tissue Expression of the SARS‐CoV‐2 Receptor ACE2 in Mice | output | 1 | 79,804 | 4 | 239,003 |
The angiotensin‐converting enzyme 2 (ACE2) is an established receptor and entry point for the novel SARS‐CoV‐2 coronavirus, as the spike protein on the viral envelope binds the ACE2 receptor. Published histological profiling revealed ACE2 to be highly expressed on human lung alveolar epithelial cells and on enterocytes... | input | 2 | 79,804 | 4 | 239,004 |
Please summerize the given abstract to a title | instruction | 0 | 79,820 | 4 | 239,050 |
Genetic Models | output | 1 | 79,820 | 4 | 239,051 |
Genetically altered rat and mouse models have been instrumental in the functional analysis of genes in a physiological context. In particular, studies on the renin-angiotensin system (RAS) have profited from this technology in the past. In this review, we summarize the existing animal models for the protective axis of ... | input | 2 | 79,820 | 4 | 239,052 |
Please summerize the given abstract to a title | instruction | 0 | 79,840 | 4 | 239,110 |
FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome | output | 1 | 79,840 | 4 | 239,111 |
Prevention of SARS-CoV-2 entry in cells through the modulation of viral host receptors, such as ACE2, could represent a new therapeutic approach complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive. Here, we identify the farnesoid X receptor (FXR) as a direct regulator of ACE2 t... | input | 2 | 79,840 | 4 | 239,112 |
Please summerize the given abstract to a title | instruction | 0 | 79,902 | 4 | 239,296 |
End of preview. Expand in Data Studio
- Downloads last month
- 2