message stringlengths 4 6.09k | message_type stringclasses 3
values | message_id int64 0 2 | conversation_id int64 52.9k 898k | cluster float64 62 62 | __index_level_0__ int64 158k 2.69M |
|---|---|---|---|---|---|
Rapid large-scale testing is essential for controlling the ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The standard diagnostic pipeline for testing SARS-CoV-2 presence in patients with an ongoing infection is predominantly based on pharyngeal swabs, from which the viral RNA is extr... | input | 2 | 83,304 | 62 | 249,504 |
Please summerize the given abstract to a title | instruction | 0 | 83,310 | 62 | 249,520 |
Tracking SARS-CoV-2 RNA through the wastewater treatment process | output | 1 | 83,310 | 62 | 249,521 |
The municipal sewage carries the new coronavirus (SARS-CoV-2), shed by COVID-19 patients, to wastewater treatment plants. Proper wastewater treatment can provide an important barrier for preventing uncontrolled discharged of the virus into the environment. However, the role of the different wastewater treatment stages ... | input | 2 | 83,310 | 62 | 249,522 |
Please summerize the given abstract to a title | instruction | 0 | 83,406 | 62 | 249,808 |
In silico analysis of mismatches in RT-qPCR assays of 177 SARS-CoV-2 sequences from Brazil | output | 1 | 83,406 | 62 | 249,809 |
INTRODUCTION: Quantitative reverse transcription polymerase chain reaction (RT-qPCR) can detect the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in a highly specific manner. However, a decrease in the specificity of PCR assays for their targets may lead to false negative results. METHODS: Here, 177 high... | input | 2 | 83,406 | 62 | 249,810 |
Please summerize the given abstract to a title | instruction | 0 | 83,827 | 62 | 251,071 |
Comparison of Abbott COVID-19 testing Platforms for timely results- CMCVAMC experience | output | 1 | 83,827 | 62 | 251,072 |
INTRODUCTION/OBJECTIVE: COVID-19 is a new disease, caused by the SARS-CoV-2 coronavirus capable of causing severe disease and death. The Alinity-m has a high throughput and random-access features that are not on the Abbott m2000, both of which had been validated and brought into clinical use for high throughput SARS-Co... | input | 2 | 83,827 | 62 | 251,073 |
Please summerize the given abstract to a title | instruction | 0 | 83,904 | 62 | 251,302 |
Swabbing the Urban Environment - A Pipeline for Sampling and Detection of SARS-CoV-2 From Environmental Reservoirs | output | 1 | 83,904 | 62 | 251,303 |
To control community transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the 2020 global pandemic, most countries implemented strategies based on direct human testing, face covering, and surface disinfection. Under the assumption that the main route of transmission includes aerosols and ... | input | 2 | 83,904 | 62 | 251,304 |
Please summerize the given abstract to a title | instruction | 0 | 84,173 | 62 | 252,109 |
Rapid point-of-care detection of SARS-CoV-2 using reverse transcription loop-mediated isothermal amplification (RT-LAMP) | output | 1 | 84,173 | 62 | 252,110 |
BACKGROUND: Fast, reliable and easy to handle methods are required to facilitate urgently needed point-of-care testing (POCT) in the current coronavirus pandemic. Life-threatening severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread all over the world, infecting more than 33,500,000 people an... | input | 2 | 84,173 | 62 | 252,111 |
Please summerize the given abstract to a title | instruction | 0 | 84,178 | 62 | 252,124 |
External Quality Assessment for Molecular Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Clinical Laboratories | output | 1 | 84,178 | 62 | 252,125 |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a huge threat to public health. Viral nucleic acid testing is the diagnostic gold standard and can play an important role in the prevention and control of this infection. In this study, bacteriophage MS2 virus-like particles encapsulating specific RNA s... | input | 2 | 84,178 | 62 | 252,126 |
Please summerize the given abstract to a title | instruction | 0 | 84,275 | 62 | 252,415 |
Low Volume in Vitro Diagnostic Proton NMR Spectroscopy of Human Blood Plasma for Lipoprotein and Metabolite Analysis: Application to SARS-CoV-2 Biomarkers | output | 1 | 84,275 | 62 | 252,416 |
The utility of low sample volume in vitro diagnostic (IVDr) proton nuclear magnetic resonance (1H NMR) spectroscopic experiments on blood plasma for information recovery from limited availability or high value samples was exemplified using plasma from patients with SARS-CoV-2 infection and normal controls. 1H NMR spect... | input | 2 | 84,275 | 62 | 252,417 |
Please summerize the given abstract to a title | instruction | 0 | 84,465 | 62 | 252,985 |
Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies | output | 1 | 84,465 | 62 | 252,986 |
SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of infection, can inform clinical measures and interventions such as test-based screening. We used... | input | 2 | 84,465 | 62 | 252,987 |
Please summerize the given abstract to a title | instruction | 0 | 84,560 | 62 | 253,270 |
Rapid Detection of SARS-CoV-2 using Graphene-based IoT Integrated Advanced Electrochemical Biosensor | output | 1 | 84,560 | 62 | 253,271 |
Unique characteristics like large surface area, excellent conductivity, functionality, ease of fabrication, etc., of graphene and its derivatives, have been extensively studied as potential candidates in healthcare applications. They have been utilized as a potential nanomaterial in biosensor fabrication for commercial... | input | 2 | 84,560 | 62 | 253,272 |
Please summerize the given abstract to a title | instruction | 0 | 84,593 | 62 | 253,369 |
Reciprocating-flowing on-a-chip enables ultra-fast immunobinding for multiplexed rapid ELISA detection of SARS-CoV-2 antibody | output | 1 | 84,593 | 62 | 253,370 |
The worldwide epidemic of novel coronavirus disease (COVID-19) has led to a strong demand for highly efficient immunobinding to achieve rapid and accurate on-site detection of SARS-CoV-2 antibodies. However, hour-scale time-consumption is usually required to ensure the adequacy of immunobinding on expensive large instr... | input | 2 | 84,593 | 62 | 253,371 |
Please summerize the given abstract to a title | instruction | 0 | 84,747 | 62 | 253,831 |
Diagnostic performance of CerTest and Panbio antigen rapid diagnostic tests to diagnose SARS-CoV-2 infection | output | 1 | 84,747 | 62 | 253,832 |
OBJECTIVES: Antigen rapid diagnostic tests (Ag-RDT) have been developed as reliable tools to control the SARS-CoV-2 pandemic. The objective of our study was to evaluate the diagnostic performance of two Ag-RDTs. METHODS: We evaluated CerTest SARS-CoV-2 Ag One Step Card Test and Panbio COVID-19 Ag Rapid Test Device Ag-R... | input | 2 | 84,747 | 62 | 253,833 |
Please summerize the given abstract to a title | instruction | 0 | 84,811 | 62 | 254,023 |
Stability of SARS-CoV-2 RNA in Viral Lysis Buffer Stored at Different Temperatures | output | 1 | 84,811 | 62 | 254,024 |
Objectives The present COVID-19 pandemic resulted in an increased need for molecular diagnostic testing Delay in the specimen processing and suboptimal storage of suspected samples in laboratories leads to degradation of SARS-CoV-2 viral RNA Viral lysis buffers from RNA extraction kits have the potential to stabilize RN... | input | 2 | 84,811 | 62 | 254,025 |
Please summerize the given abstract to a title | instruction | 0 | 85,011 | 62 | 254,623 |
Detection of SARS-CoV-2 in respiratory samples from cats in the UK associated with human-to-cat transmission | output | 1 | 85,011 | 62 | 254,624 |
OBJECTIVES: The aim of the study was to find evidence of SARS-CoV-2 infection in UK cats. DESIGN: Tissue samples were tested for SARS-CoV-2 antigen using immunofluorescence and for viral RNA by in situ hybridisation. A set of 387 oropharyngeal swabs that had been submitted for routine respiratory pathogen testing was t... | input | 2 | 85,011 | 62 | 254,625 |
Please summerize the given abstract to a title | instruction | 0 | 85,200 | 62 | 255,190 |
Error Correction Codes for COVID-19 Virus and Antibody Testing: Using Pooled Testing to Increase Test Reliability | output | 1 | 85,200 | 62 | 255,191 |
We consider a novel method to increase the reliability of COVID-19 virus or antibody tests by using specially designed pooled testings. Instead of testing nasal swab or blood samples from individual persons, we propose to test mixtures of samples from many individuals. The pooled sample testing method proposed in this ... | input | 2 | 85,200 | 62 | 255,192 |
Please summerize the given abstract to a title | instruction | 0 | 85,277 | 62 | 255,421 |
Epidemiological evaluation of sewage surveillance as a tool to detect the presence of COVID-19 cases in a low case load setting | output | 1 | 85,277 | 62 | 255,422 |
In low prevalence settings the development of sensitive and specific quantitative Reverse Transcription Polymerase Chain Reaction tests to detect SARS-CoV − 2 (the virus causing COVID-19) in sewage presents the possibility of using sewage sampling as a diagnostic test for the presence of infected people in the catchmen... | input | 2 | 85,277 | 62 | 255,423 |
Please summerize the given abstract to a title | instruction | 0 | 85,310 | 62 | 255,520 |
Feasibility and accuracy of a novel saliva sampling method for large-scale SARS-CoV-2 screening in children < 12 years of age | output | 1 | 85,310 | 62 | 255,521 |
Objectives Children have been disproportionately affected during the COVID-19 pandemic. Novel test strategies are urgently needed to ensure safe operation of schools and childcare institutions and to avoid prolonged closures. Methods A weekly SARS-CoV-2 sentinel study in primary schools, kindergartens and childcare fac... | input | 2 | 85,310 | 62 | 255,522 |
Please summerize the given abstract to a title | instruction | 0 | 85,338 | 62 | 255,604 |
Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay | output | 1 | 85,338 | 62 | 255,605 |
The recent outbreak of novel coronavirus (SARS-CoV-2) causing COVID-19 disease spreads rapidly in the world. Rapid and early detection of SARS-CoV-2 facilitates early intervention and prevents the disease spread. Here, we present an All-In-One Dual CRISPR-Cas12a (AIOD-CRISPR) assay for one-pot, ultrasensitive, and visu... | input | 2 | 85,338 | 62 | 255,606 |
Please summerize the given abstract to a title | instruction | 0 | 85,398 | 62 | 255,784 |
Sample-to-Answer and Routine Real-Time RT-PCR: A Comparison of Different Platforms for SARS-CoV-2 Detection | output | 1 | 85,398 | 62 | 255,785 |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading all over the world and has caused millions of deaths. Several sample-to-answer platforms, including Cepheid Xpert Xpress SARS-CoV-2 (Xpert Xpress), have received emergency use authorization for SARS-CoV-2 nucleic acid detection as a point of care... | input | 2 | 85,398 | 62 | 255,786 |
Please summerize the given abstract to a title | instruction | 0 | 85,416 | 62 | 255,838 |
shinyCurves, a shiny web application to analyse multisource qPCR amplification data: a COVID 19 case study | output | 1 | 85,416 | 62 | 255,839 |
Quantitative, reverse transcription polymerase chain reaction (qRT-PCR) has been the gold-standard tool for viral detection during the SARS-CoV-2 pandemic. However, the desperate rush for a quick diagnosis led the use of very different types of machines and proprietary software, leading to an unbearable complexity of d... | input | 2 | 85,416 | 62 | 255,840 |
Please summerize the given abstract to a title | instruction | 0 | 85,431 | 62 | 255,883 |
Feasibility and utility of facemask sampling in the detection of SARS-CoV-2 during an ongoing pandemic | output | 1 | 85,431 | 62 | 255,884 |
Easy access to screening for timely identification and isolation of infectious COVID-19 patients remains crucial in sustaining the international efforts to control COVID-19 spread. A major barrier limiting broad-based screening is the lack of a simple, rapid, and cost-effective COVID-19 testing method. We evaluated the... | input | 2 | 85,431 | 62 | 255,885 |
Please summerize the given abstract to a title | instruction | 0 | 85,434 | 62 | 255,892 |
Evaluation of mobile real-time polymerase chain reaction tests for the detection of severe acute respiratory syndrome coronavirus 2 | output | 1 | 85,434 | 62 | 255,893 |
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), calls for prompt and accurate diagnosis and rapid turnaround time for test results to limit transmission. Here, we evaluated two independent molecular assays, the Biomeme SARS-CoV-2 test, and the Pr... | input | 2 | 85,434 | 62 | 255,894 |
Please summerize the given abstract to a title | instruction | 0 | 85,468 | 62 | 255,994 |
Verification and Validation of SARS-CoV-2 Assay Performance on the Abbott m2000 and Alinity m Systems | output | 1 | 85,468 | 62 | 255,995 |
We verified the analytical performance of the Abbott RealTime SARS-CoV-2 assay on the m2000 system and compared its clinical performance to the CDC 2019-nCoV Real-Time PCR Diagnostic Panel and the ThermoFisher TaqPath RT-PCR COVID-19 kit. We also performed a bridging study comparing the RealTime SARS-CoV-2 assay with t... | input | 2 | 85,468 | 62 | 255,996 |
Please summerize the given abstract to a title | instruction | 0 | 85,551 | 62 | 256,243 |
Detection of SARS-CoV-2 in air and on surfaces in rooms of infected nursing home residents | output | 1 | 85,551 | 62 | 256,244 |
There is an ongoing debate on airborne transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a risk factor for infection. In this study, the level of SARS-CoV-2 in air and on surfaces of SARS-CoV-2 infected nursing home residents was assessed to gain insight in potential transmission routes. D... | input | 2 | 85,551 | 62 | 256,245 |
Please summerize the given abstract to a title | instruction | 0 | 85,618 | 62 | 256,444 |
A Novel Approach to the Bioluminescent Detection of the SARS-CoV-2 ORF1ab Gene by Coupling Isothermal RNA Reverse Transcription Amplification with a Digital PCR Approach | output | 1 | 85,618 | 62 | 256,445 |
The COVID-19 pandemic caused by the SARS-CoV-2 virus, which first emerged in December 2019, represents an ongoing global public health emergency. Here, we developed an improved and highly sensitive approach to SARS-CoV-2 detection via coupling bioluminescence in real-time (BART) and reverse-transcriptase loop-mediated ... | input | 2 | 85,618 | 62 | 256,446 |
Please summerize the given abstract to a title | instruction | 0 | 85,694 | 62 | 256,672 |
Ad hoc laboratory-based surveillance of SARS-CoV-2 by real-time RT-PCR using minipools of RNA prepared from routine respiratory samples | output | 1 | 85,694 | 62 | 256,673 |
We report a laboratory-based surveillance for SARS-CoV-2 using minipools of respiratory samples submitted for routine diagnostics. We tested a total of 70 minipools resembling 700 samples shortly before the upsurge of cases in Germany. We identified one SARS-CoV-2 positive patient. Our approach proved its concept, is e... | input | 2 | 85,694 | 62 | 256,674 |
Please summerize the given abstract to a title | instruction | 0 | 85,706 | 62 | 256,708 |
Prolonged Detection of SARS CoV2 RNA in Extracellular Vesicles in Nasal Swab RT-PCR Negative Patients | output | 1 | 85,706 | 62 | 256,709 |
Background: There is a prolonged RT PCR positivity seen in COVID-19 infected patients up to 2 to 3 months. It is assumed that this virus is usually non-infective but there are hardly any study on the reactivation of this virus within the respiratory tract. We aim to investigate the presence of viral particles inside Ex... | input | 2 | 85,706 | 62 | 256,710 |
Please summerize the given abstract to a title | instruction | 0 | 85,741 | 62 | 256,813 |
SPECIFIC DETECTION OF SARS-COV-2 VARIANTS B.1.1.7 (ALPHA) AND B.1.617.2 (DELTA) USING A ONE-STEP QUANTITATIVE PCR ASSAY | output | 1 | 85,741 | 62 | 256,814 |
In this report, we describe the development of an RT-qPCR assay, termed Alpha Delta assay, which can detect SARS-COV-2 (SC-2) and distinguish between the Alpha (B.1.1.7) and Delta (B.1.617.2) variants. The Alpha- and Delta-specific reactions in the assay target mutations that are strongly linked to the target variant. ... | input | 2 | 85,741 | 62 | 256,815 |
Please summerize the given abstract to a title | instruction | 0 | 85,797 | 62 | 256,981 |
Wastewater based epidemiology as a silent sentinel of the trend of SARS-CoV-2 circulation in the community in central Argentina | output | 1 | 85,797 | 62 | 256,982 |
Monitoring wastewater for the traces of viruses allows effective surveillance of entire communities, including symptomatic and asymptomatic infected individuals, providing information on whether a specific pathogen is circulating in a population. In the context of the COVID-19 pandemic, 261 wastewater samples from six ... | input | 2 | 85,797 | 62 | 256,983 |
Please summerize the given abstract to a title | instruction | 0 | 85,807 | 62 | 257,011 |
Monitoring waves of the COVID-19 pandemic: Inferences from WWTPs of different sizes | output | 1 | 85,807 | 62 | 257,012 |
Wastewater based epidemiology was employed to track the spread of SARS-CoV-2 within the sewershed areas of 10 wastewater treatment plants (WWTPs) in Catalonia, Spain. A total of 185 WWTPs inflow samples were collected over the period consisting of both the first wave (mid-March to June) and the second wave (July to Nov... | input | 2 | 85,807 | 62 | 257,013 |
Please summerize the given abstract to a title | instruction | 0 | 86,115 | 62 | 257,935 |
Comparison of SARS-CoV2 N gene real-time RT-PCR targets and commercially available mastermixes | output | 1 | 86,115 | 62 | 257,936 |
We aim to test four one-step RT real-time mastermix options for use in SARS-CoV2 real-time PCR, with three primer/probe assays targeting the N gene. The lower limit of detection is determined using a SARS CoV2 N gene RNA transcript dilution series (to 1 copy/µl) and verified using 74 nose and throat swabs. The N2 assay... | input | 2 | 86,115 | 62 | 257,937 |
Please summerize the given abstract to a title | instruction | 0 | 86,132 | 62 | 257,986 |
Comparison of a Point-of-Care Assay and a High-Complexity Assay for Detection of SARS-CoV-2 RNA | output | 1 | 86,132 | 62 | 257,987 |
BACKGROUND: Numerous nucleic acid amplification assays utilizing different target genes of the SARS-CoV-2 genome have received emergency use authorization (EUA) by the United States Food and Drug Administration (FDA). Limited data are available comparing the test performance characteristics of these assays. METHODS: A ... | input | 2 | 86,132 | 62 | 257,988 |
Please summerize the given abstract to a title | instruction | 0 | 86,331 | 62 | 258,583 |
High Efficacy of Saliva in Detecting SARS-CoV-2 by RT-PCR in Adults and Children | output | 1 | 86,331 | 62 | 258,584 |
Rising demands for repetitive SARS-CoV-2 screens and mass testing necessitate additional test strategies. Saliva may serve as an alternative to nasopharyngeal swab (NPS) as its collection is simple, non-invasive and amenable for mass- and home testing, but its rigorous validation, particularly in children, is missing. ... | input | 2 | 86,331 | 62 | 258,585 |
Please summerize the given abstract to a title | instruction | 0 | 86,524 | 62 | 259,162 |
Detection and infectivity potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) environmental contamination in isolation units and quarantine facilities | output | 1 | 86,524 | 62 | 259,163 |
OBJECTIVES: Environmental surfaces have been suggested as likely contributors to the transmission of COVID-19. This study assessed the infectivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) contamination on surfaces and objects in hospital isolation units and a quarantine hotel. METHODS: SARS-CoV-2... | input | 2 | 86,524 | 62 | 259,164 |
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