input stringlengths 114 1.09k | output stringlengths 17 4.84k |
|---|---|
### Instruction:
Please summerize the given abstract to a title
### Response:
Adaptation-proof SARS-CoV-2 vaccine design
### Response:
| Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface spike glycoprotein - a major antibody target - is critical for virus entry via engagement of human angiotensin-converting enzyme 2 (ACE2) receptor. Despite successes with existing vaccines and therapies that primarily target the receptor binding domai... |
### Instruction:
Please summerize the given abstract to a title
### Response:
SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity
### Response:
| The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the ACE2 receptor and is cleaved by TMPRSS2. However, whether S mutations affect SARS-CoV-2 cell entry remains unknown. Here, we sho... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A new proposed mechanism of some known drugs targeting the sars-cov-2 spike glycoprotein using molecular docking
### Response:
| COVID-19 is caused by the novel enveloped beta-coronavirus with a genomic RNA closely related to severe acute respiratory syndrome-corona virus (SARS-CoV) and is named coronavirus 2 (SARS-CoV-2) In this study, six synthetic drugs were specifically docked against the RBD Most of the six compounds were observed to fit ni... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Potent mouse monoclonal antibodies that block SARS-CoV-2 infection
### Response:
| Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has developed into a global pandemic since its first outbreak in the winter of 2019. An extensive investigation of SARS-CoV-2 is critical for disease control. Various recombinant monoclonal antibodies of human o... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Why Blood Group A Individuals Are at Risk Whereas Blood Group O Individuals Might Be Protected from SARS-CoV-2 (COVID-19) Infection: A Hypothesis Regarding How the Virus Invades the Human Body via Abo(H) Blood Group-Determining Carbohydrates... | While the angiotensin converting enzyme 2 (ACE2) protein is defined as the primary severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, the viral serine molecule might be mobilized by the host's transmembrane protease serine subtype 2 (TMPRSS2) enzyme from the viral spike (S) protein and hijack the ho... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A computational methodology to diagnose sequence-variant dynamic perturbations by comparing atomic protein structures
### Response:
| MOTIVATION: The objective is to diagnose dynamics perturbations caused by amino acid mutations as prerequisite to assess protein functional health or drug failure, simply using network models of protein X-ray structures. RESULTS: We find that the differences in the allocation of the atomic interactions of each amino ac... |
### Instruction:
Please summerize the given abstract to a title
### Response:
RBD-Modified Bacterial Vesicles Elicited Potential Protective Immunity against SARS-CoV-2
### Response:
| [Image: see text] The disease caused by SARS-CoV-2 infection threatens human health. In this study, we used high-pressure homogenization technology not only to efficiently drive the bacterial membrane to produce artificial vesicles but also to force the fusion protein ClyA-receptor binding domain (RBD) to pass through ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning
### Response:
| To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. Our literature and clinical trial survey showed that the whole virus, as well as the spike (S) protein, nucleocapsid (N) protein, and m... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2
### Response:
| 3C-like protease (3CLpro) is one of two proteases that process and liberate functional viral proteins essential for the maturation and infectivity of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19. It has been suggested that 3CLpro is catalytically active as a dimer, ma... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Study of the Spike (S) glycoprotein from the SARSCoV-2 as a possible source of translocating peptides of biomedical interest
### Response:
| Membranes are natural selective barriers necessary for the correct function of human cells as they control the entry of diverse molecules into the intracellular space Although small and polar molecules such as amino acids and ions cancome across the membrane through channels, larger macromolecules such as proteins and ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Biophysical characterization of HRC peptide analogs interaction with heptad repeat regions of the SARS-coronavirus Spike fusion protein core
### Response:
| The Spike (S) protein of SARS-coronavirus (SARS-CoV) mediates viral entry into host cells. It contains two heptad repeat regions, denoted HRN and HRC. We have identified the location of the two interacting HR regions that form the six-helix bundle (B. Tripet, et al, J. Biol. Chem., 279: 20836–20849, 2004). In this stud... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Shape Complementarity Optimization of Antibody-Antigen Interfaces: the Application to SARS-CoV-2 Spike Protein
### Response:
| Many factors influence biomolecules binding, and its assessment constitutes an elusive challenge in computational structural biology. In this respect, the evaluation of shape complementarity at molecular interfaces is one of the main factors to be considered. We focus on the particular case of antibody-antigen complexe... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Alum Induces Protective Immunity and Reduces Immune Enhancement
### Response:
| We developed a severe acute respiratory syndrome (SARS) subunit recombinant protein vaccine candidate based on a highyielding, yeast- engineered, receptor-binding domain (RBD219-N1) of the SARS beta-coronavirus (SARS-CoV) spike (S) protein. When formulated with Alhydrogel®, RBD219-N1 induced high-level neutralizing ant... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors
### Response:
| Here, we report the topology-matched design of heteromultivalent nanostructures as potent and broad-spectrum virus entry inhibitors based on the host cell membrane. Initially, we investigate the virus binding dynamics to validate the better binding performance of the heteromultivalent moieties as compared to homomultiv... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Detection of binding sites on SARS-CoV-2 Spike protein receptor-binding domain by molecular dynamics simulations in mixed solvents
### Response:
| The novel SARS-CoV-2 uses the ACE2 (Angiotensin-Converting Enzyme 2) receptor as an entry point. Insights on S protein receptor-binding domain (RBD) interaction with ACE2 receptor and drug repurposing has accelerated drug discovery for the novel SARS-CoV-2 infection. Finding small molecule binding sites in the S protei... |
### Instruction:
Please summerize the given abstract to a title
### Response:
The presentation of SARS-CoV-2 peptides by the common HLA-A*02:01 molecule
### Response:
| CD8+ T cells are crucial for anti-viral immunity, however, understanding T cell responses requires the identification of epitopes presented by Human Leukocyte Antigens (HLA). To date, few SARS-CoV-2-specific CD8+ T cell epitopes have been described. Internal viral proteins are typically more conserved than surface prot... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry
### Response:
| SARS-CoV-2 spike proteins are responsible for the membrane fusion event, which allows the virus to enter the host cell and cause infection. This process starts with the binding of the spike extramembrane domain to the angiotensin-converting enzyme 2 (ACE2), a membrane receptor highly abundant in the lungs. In this stud... |
### Instruction:
Please summerize the given abstract to a title
### Response:
DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in mice
### Response:
| More than 65 million people have been confirmed infection with SARS-CoV-2 and more than 1 million have died from COVID-19 and this pandemic remains critical worldwide. Effective vaccines are one of the most important strategies to limit the pandemic. Here, we report a construction strategy of DNA vaccine candidates exp... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Comparison of random and site directed mutation effects on the efficacy between lead SARS-CoV2 anti-protease drugs Indinavir and Hydroxychloroquine
### Response:
| Abstract The diversification of virus can be attributed to random mutations leading to the development of drug resistance. The variations can be inherited from one generation to the other rendering the drug ineffective. However, a pharmacologically induced selection pressure can be countered by introducing drugs better... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Structure and dynamics of RNA guanine quadruplexes in SARS-CoV-2 genome. Original strategies against emerging viruses
### Response:
| Guanine quadruplexes (G4) structures in viral genome have a key role in modulating viruses’ biological activity. While several DNA G4 structures have been experimentally resolved, RNA G4s are definitely less explored. We report the first calculated G4 structure of the RG-1 RNA sequence of SARS-CoV-2 genome, obtained by... |
### Instruction:
Please summerize the given abstract to a title
### Response:
The SARS-CoV S glycoprotein
### Response:
| The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. Recent rapid advances in our knowledge of the structure and function of this protein have le... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Dieckol and Its Derivatives as Potential Inhibitors of SARS-CoV-2 Spike Protein (UK Strain: VUI 202012/01): A Computational Study
### Response:
| The high risk of morbidity and mortality associated with SARS-CoV-2 has accelerated the development of many potential vaccines. However, these vaccines are designed against SARS-CoV-2 isolated in Wuhan, China, and thereby may not be effective against other SARS-CoV-2 variants such as the United Kingdom variant (VUI-202... |
### Instruction:
Please summerize the given abstract to a title
### Response:
MERS-CoV spike protein: a key target for antivirals.
### Response:
| INTRODUCTION The continual Middle East respiratory syndrome (MERS) threat highlights the importance of developing effective antiviral therapeutics to prevent and treat MERS coronavirus (MERS-CoV) infection. A surface spike (S) protein guides MERS-CoV entry into host cells by binding to cellular receptor dipeptidyl pept... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Development of new vaccine target against SARS-CoV2 using envelope (E) protein: An evolutionary, molecular modeling and docking based study
### Response:
| COVID-19 is one of the fatal pandemic throughout the world. For cellular fusion, its antigenic peptides are presented by major histocompatibility complex (MHC) in humans. Therefore, exploration into residual interaction details of CoV2 with MHCs shall be a promising point for instigating the vaccine development. Envelo... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Molecular dynamics simulation study of effects of key mutations in SARS-CoV-2 on protein structures
### Response:
| SARS-CoV-2 has been spreading rapidly since 2019 and has produced large-scale mutations in the genomes. Differences in gene sequences may lead to changes in protein structure and traits, which would have a great impact on the epidemiological characteristics. In this study, we selected the key mutations of SARS-CoV-2, i... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice
### Response:
| The increasing numbers of infected cases of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses serious threats to public health and the global economy. Most SARS-CoV-2 neutralizing antibodies target the receptor binding domain (RBD) and some the N-terminal d... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Fusion Protein of Rotavirus VP6 and SARS-CoV-2 Receptor Binding Domain Induces T Cell Responses
### Response:
| Vaccines based on mRNA and viral vectors are currently used in the frontline to combat the ongoing pandemic caused by the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). However, there is still an urgent need for alternative vaccine technologies inducing/boosting long-lasting and cross-reactive immu... |
### Instruction:
Please summerize the given abstract to a title
### Response:
501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro
### Response:
| The newly emerging variants of SARS-CoV-2 from South Africa (B.1.351/501Y.V2) and Brazil (P.1/501Y.V3) have led to a higher infection rate and reinfection of COVID-19 patients. We found that the mutations K417N, E484K, and N501Y within the receptor-binding domains (RBDs) of the virus could confer ~2-fold higher binding... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2
### Response:
| BACKGROUND: An outbreak of infection caused by SARS-CoV-2 recently has brought a great challenge to public health. Rapid identification of immune epitopes would be an efficient way to screen the candidates for vaccine development at the time of pandemic. This study aimed to predict the protective epitopes with bioinfor... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactions
### Response:
| Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) causing coronavirus disease 2019 (COVID-19) has infected ten millions of people across the globe, and massive mutations in virus genome have occurred during the rapid spread of this novel coronavirus. Variance in protein sequence might lead to ch... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Severity, Pathogenicity and Transmissibility of Delta and Lambda Variants of SARS-CoV-2, Toxicity of Spike Protein and Possibilities for Future Prevention of COVID-19
### Response:
| The World Health Organization reports that SARS-CoV-2 has infected over 220 million people and claimed over 4.7 million lives globally. While there are new effective vaccines, the differences in behavior of variants are causing challenges in vaccine development or treatment. Here, we discuss Delta, a variant of concern... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics
### Response:
| The worldwide COVID-19 pandemic caused by the SARS-CoV-2 betacoronavirus has highlighted the need for a synthetic biology approach to create reliable and scalable sources of viral antigen for uses in diagnostics, therapeutics and basic biomedical research. Here, we adapt plasmid-based systems in the eukaryotic microalg... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Design an Efficient Multi-Epitope Peptide Vaccine Candidate Against SARS-CoV-2: An in silico Analysis
### Response:
| BACKGROUND: To date, no specific vaccine or drug has been proven to be effective against SARS-CoV-2 infection. Therefore, we implemented an immunoinformatic approach to design an efficient multi-epitopes vaccine against SARS-CoV-2. RESULTS: The designed-vaccine construct consists of several immunodominant epitopes from... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Development of new vaccine target against SARS-CoV2 using envelope (E) protein: An evolutionary, molecular modeling and docking based study
### Response:
| COVID-19 is one of the fatal pandemic throughout the world. For cellular fusion, its antigenic peptides are presented by major histocompatibility complex (MHC) in humans. Therefore, exploration into residual interaction details of CoV2 with MHCs shall be a promising point for instigating the vaccine development. Envelo... |
### Instruction:
Please summerize the given abstract to a title
### Response:
SARS-CoV-2 spike protein binds heparan sulfate in a length- and sequence-dependent manner
### Response:
| Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is causing an unprecedented global pandemic demanding the urgent development of therapeutic strategies. Microarray binding experiments using an extensive heparan sulfate (HS) oligosaccharide library showed the spike of SARS-CoV-2 can bind HS in a leng... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Intranasal vaccination of recombinant adeno-associated virus encoding receptor-binding domain of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein induces strong mucosal immune responses and provides long-term protection... | We have previously reported that a subunit protein vaccine based on the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein and a recombinant adeno-associated virus (rAAV)-based RBD (RBD-rAAV) vaccine could induce highly potent neutralizing Ab responses in immunized a... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
### Response:
| The novel highly transmissible human coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Thus far, there is no approved therapeutic drug specifically targeting this emerging virus. Here we report the isolation and characterization of a panel of human neutralizing monoclonal antibodies targeting the ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2
### Response:
| Abstract Objectives Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace Here, we describe rational antigen design through to manufacturability and vaccine efficacy of a prefusion-stabilised spike (S) protein, Sclamp, in combination with ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
### Response:
| A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) of the spike protein of SARS-CoV-2 to epithelial cells. In Vero E6 cells, hypoxia reduces the protein levels of ACE2 and neuropilin-1 (NRP1), ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Structural and functional modelling of SARS-CoV-2 entry in animal models
### Response:
| SARS-CoV-2 is the novel coronavirus responsible for the outbreak of COVID-19, a disease that has spread to over 100 countries and, as of the 26th July 2020, has infected over 16 million people. Despite the urgent need to find effective therapeutics, research on SARS-CoV-2 has been affected by a lack of suitable animal ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
ACE2 Decoy Receptor Generated by High-throughput Saturation Mutagenesis Efficiently Neutralizes SARS-CoV-2 and Its Prevalent Variants.
### Response:
| The recent global pandemic was a spillover from the SARS-CoV-2 virus. Viral entry involves the receptor binding domain (RBD) of the viral spike protein interacting with the protease domain (PD) of the cellular receptor, ACE2. We hereby present a comprehensive mutational landscape of the effects of ACE2-PD point mutatio... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Steep Decline in Binding Capability of SARS-CoV-2 Omicron Variant (B.1.1.529) RBD to the Antibodies in Early COVID-19 Convalescent Sera and Inactivated Vaccine Sera
### Response:
| A new SARS-CoV-2 variant B.1.1.529 was named by the WHO as Omicron and classified as a Variant of Concern (VOC) on 26 November 2021. Because this variant has more than 50 mutations, including 30 mutations on the spike, it has generated a lot of concerns on the potential impacts of the VOC on COVID-19. Here through ELIS... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Interaction analyses of SARS-CoV-2 spike protein based on fragment molecular orbital calculations
### Response:
| At the stage of SARS-CoV-2 infection in human cells, the spike protein consisting of three chains, A, B, and C, with a total of 3300 residues plays a key role, and thus its structural properties and the binding nature of receptor proteins to host human cells or neutralizing antibodies has attracted considerable interes... |
### Instruction:
Please summerize the given abstract to a title
### Response:
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2
### Response:
| SARS-CoV-2 has been spreading around the world for the past year. Recently, several variants such as B.1.1.7 (alpha), B.1.351 (beta), and P.1 (gamma), which share a key mutation N501Y on the receptor-binding domain (RBD), appear to be more infectious to humans. To understand the underlying mechanism, we used a cell sur... |
### Instruction:
Please summerize the given abstract to a title
### Response:
SARS‐CoV‐2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination
### Response:
| The receptor‐binding domain (RBD) of the SARS‐CoV‐2 spike protein is a candidate vaccine antigen that binds angiotensin‐converting enzyme 2 (ACE2), leading to virus entry. Here, it is shown that rapid conversion of recombinant RBD into particulate form via admixing with liposomes containing cobalt‐porphyrin‐phospholipi... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Inhibition of S-protein RBD and hACE2 Interaction for Control of SARSCoV-2 Infection (COVID-19)
### Response:
| BACKGROUND: COVID-19 has become pandemic with higher morbidity and mortality rates after its start from Wuhan city of China. The infection by RNA virus, also known as SARS-CoV-2 or 2019-nCoV, from beta class of corona viruses has been found to be responsible for COVID-19. Structural analysis and evidences have been ind... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Topologically engineered antibodies and Fc-fusion proteins: a new class of multifunctional therapeutic candidates for SARS-CoV-2, cancer, and other disease
### Response:
| The ability of antibodies and Fc-fusion proteins to bind multiple targets cooperatively is limited by their topology. Here we describe our discovery that ACE2 Fc-fusion proteins spontaneously cross-dimerize, forming topologically distinct "superdimers" that demonstrate extraordinary SARS-CoV-2 intra-spike cooperative b... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Immunoinformatics in covid-19 vaccine development: The role of hla system
### Response:
| Individual genetic variation may help to explain different immune responses to a coronavirus SARS-CoV-2 across a population. The in silico computer simulation methodology provides the experimental community with a more complete list of SARS-CoV-2 immunogenic peptides presented by the antigens of the HLA system. This re... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Molecular dynamics of spike variants in the locked conformation: RBD interfaces, fatty acid binding and furin cleavage sites
### Response:
| Since December 2019 the SARS-CoV-2 virus has infected billions of people around the world and caused millions of deaths. The ability for this RNA virus to mutate has produced variants that have been responsible for waves of infections across the globe. The spike protein on the surface of the SARS-CoV-2 virion is respon... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection
### Response:
| To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, a humanized decoy antibody (ACE2‐Fc fusion protein) was designed to target the interaction between viral spike protein and its cellular receptor, angiotensin‐converting enzyme 2 (ACE2). First, we dem... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Functional importance of the D614G mutation in the SARS-CoV-2 spike protein
### Response:
| Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus which binds its cellular receptor angiotensin-converting enzyme 2 (ACE2) and enters hosts cells through the action of its spike (S) glycoprotein displayed on the surface of the virion. Compared to the reference strain of SARS-CoV-2, the ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Immunoinformatics characterization of SARS-CoV-2 spike glycoprotein for prioritization of epitope based multivalent peptide vaccine
### Response:
| The COVID-19 pandemic caused by SARS-CoV-2 is a public health emergency of international concern and thus calling for the development of effective and safe therapeutics and prophylactics particularly a vaccine to protect against the infection. SARS-CoV-2 spike glycoprotein is an attractive candidate for a vaccine, anti... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Star-shaped molecules cross-bind to SARS-CoV2 spike α-helices in silico (preprint)
### Response:
| Despite docking to the isolated α-helix residues 960-1010 (“spring-loaded switch-folding”, SLSF) of wild-type S spike trimers of Severe Acute Respiratory Syndrome coronavirus (SARS)-CoV2, the star-shaped hydrophobic Tinosorb failed to dock to SLSF inside the S (S-SLSF) and to inhibit viral-host cell membrane fusion1. T... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization using a versatile adenovirus-inspired multimerization platform
### Response:
| The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has shown that vaccine preparedness is critical to anticipate a fast response to emergent pathogens with high infectivity. To rapidly reach herd immunity, an affordable, easy to store and versatile vaccine platform is thus desirable. We previousl... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Techniques assisting peptide vaccine and peptidomimetic design. Sidechain exposure in the SARS-CoV-2 spike glycoprotein
### Response:
| The aim of the present study is to discuss the design of peptide vaccines and peptidomimetics against SARS-COV-2, to develop and apply a method of protein structure analysis that is particularly appropriate to applying and discussing such design, and also to use that method to summarize some important features of the S... |
### Instruction:
Please summerize the given abstract to a title
### Response:
CD8(+) T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2
### Response:
| We identified SARS-CoV-2 specific antigen epitopes by HLA-A2 binding affinity analysis and characterized their ability to activate T cells. As the pandemic continues, variations in SARS-CoV-2 virus strains have been found in many countries. In this study, we directly assess the immune response to SARS-CoV-2 epitope var... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Blocking antibodies against SARS-CoV-2 RBD isolated from a phage display antibody library using a competitive biopanning strategy
### Response:
| The infection of the novel coronavirus SARS-CoV-2 have caused more than 150,000 deaths, but no vaccine or specific therapeutic antibody is currently available. SARS-CoV-2 relies on its spike protein, in particular the receptor binding domain (RBD), to bind human cell receptor angiotensin-converting enzyme 2 (ACE2) for ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Binding mode of SARS-CoV-2 fusion peptide to human cellular membrane
### Response:
| Infection of human cells by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) relies on its binding to a specific receptor and subsequent fusion of the viral and host cell membranes. The fusion peptide (FP), a short peptide segment in the spike protein, plays a central role in the initial penetration of t... |
### Instruction:
Please summerize the given abstract to a title
### Response:
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
### Response:
| SARS-CoV-2 enters host cells through an interaction between the spike glycoprotein and the angiotensin converting enzyme 2 (ACE2) receptor. Directly preventing this interaction presents an attractive possibility for suppressing SARS-CoV-2 replication. Here, we report the isolation and characterization of an alpaca-deri... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages
### Response:
| SARS-CoV-2, or COVID-19, has a devastating effect on our society, both in terms of quality of life and death rates; hence, there is an urgent need for developing safe and effective therapeutics against SARS-CoV-2. The most promising strategy to fight against this deadly virus is to develop an effective vaccine. Interna... |
### Instruction:
Please summerize the given abstract to a title
### Response:
COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning
### Response:
| To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. Our literature and clinical trial survey showed that the whole virus, as well as the spike (S) protein, nucleocapsid (N) protein, and m... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Immunogenic potential of DNA vaccine candidate, ZyCoV-D against SARS-CoV-2 in animal models
### Response:
| Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), initially originated in China in year 2019 and spread rapidly across the globe within 5 months, causing over 96 million cases of infection and over 2 million deaths. Huge efforts were undertaken to bring the COVID-19 vaccines in clinical development, so that... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Binding Ligands that Straddle an Important Contact Site on the RBD of the Covid-19 Spike Protein
### Response:
| The receptor binding domain (RBD) of the spike protein of the Covid-19 virus is responsible for attachment to human ACE2. A number of recent articles have studied monoclonal antibody blocking [8-11] and peptide inhibitors [12-16] of the Covid-19 virus. Here we report virtual ligand-based screening that targets pockets ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
The immunodominant and neutralization linear epitopes for SARS-CoV-2
### Response:
| Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocaps... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide
### Response:
| Cell penetration after recognition of the SARS-CoV-2 virus by the ACE2 receptor, and the fusion of its viral envelope membrane with cellular membranes, are the early steps of infectivity A region of the Spike protein (S) of the virus, identified as the "fusion peptide" (FP), is liberated at its N-terminal site by a spe... |
### Instruction:
Please summerize the given abstract to a title
### Response:
2019-nCoV vs. SARS-CoV: Which Truly Has a Higher ACE2 Affinity? A Quantum Chemical Perspective on Virus-Receptor Noncovalent Interactions
### Response:
| Noncovalent interaction energetics associated with ACE2 affinity differences are investigated using electronic structure methods;Our results were found to challenge previous predictions – claiming a higher affinity for 2019-nCoV compared to SARS-CoV based merely on "chemical intuition". In addition, we demonstrate that... |
### Instruction:
Please summerize the given abstract to a title
### Response:
SARS-CoV-2 RBD Neutralizing Antibody Induction is Enhanced by Particulate Vaccination
### Response:
| The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is a candidate vaccine antigen that binds angiotensin-converting enzyme 2 (ACE2), leading to virus entry. Here, it is shown that rapid conversion of recombinant RBD into particulate form via admixing with liposomes containing cobalt-porphyrin-phospholipi... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
### Response:
| The outbreak of coronavirus disease (COVID-19) in China caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. It is currently no specific viral protein targeted therapeutics yet. Viral nucleocapsid protein is a potential antiviral drug target, serving multiple critical functions during t... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Peptide-antibody Fusions Engineered by Phage Display Exhibit Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants
### Response:
| The COVID-19 pandemic has been exacerbated by the emergence of variants of concern (VoCs). Many VoC mutations are found in the viral spike protein (S-protein), and are thus implicated in host infection and response to therapeutics. Bivalent neutralizing antibodies (nAbs) targeting the S-protein receptor-binding domain ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A graph-based approach identifies dynamic H-bond communication networks in spike protein S of SARS-CoV-2
### Response:
| Corona virus spike protein S is a large homo-trimeric protein anchored in the membrane of the virion particle. Protein S binds to angiotensin-converting-enzyme 2, ACE2, of the host cell, followed by proteolysis of the spike protein, drastic protein conformational change with exposure of the fusion peptide of the virus,... |
### Instruction:
Please summerize the given abstract to a title
### Response:
AI-driven multiscale simulations illuminate mechanisms of SARS-CoV-2 spike dynamics
### Response:
| We develop a generalizable AI-driven workflow that leverages heterogeneous HPC resources to explore the time-dependent dynamics of molecular systems. We use this workflow to investigate the mechanisms of infectivity of the SARS-CoV-2 spike protein, the main viral infection machinery. Our workflow enables more efficient... |
### Instruction:
Please summerize the given abstract to a title
### Response:
High genetic barrier to escape from human polyclonal SARS-CoV-2 neutralizing antibodies
### Response:
| The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in SARS-CoV-2 convalescent and vaccinated individuals are key determinants of neutralization breadth and, consequently, the genetic barrier to viral escape. Using chimeric viruses and antibody-selected viral mutants, we show that ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection
### Response:
| In light of the recent accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral spike glycoprotein to human Angiotensin Converting Enzyme 2 (hACE2) receptor plays a central role in cell entry. We designed a series of peptides mimicking the N-terminal helix of hACE2 protein which co... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A Molecular View of Coronavirus Disease-2019 (COVID-19)
### Response:
| This article reviews the research progress of the spike protein of the virus SARS-CoV-2 that causes COVID-19, including the gene sequence and protein sequence encoding the spike protein, as well as its secondary and tertiary structure through bioinformatics tools The sequence similarlity comparsion results show that th... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Structure-based modeling of SARS-CoV-2 peptide/HLA-A02 antigens
### Response:
| As a first step toward the development of diagnostic and therapeutic tools to fight the Coronavirus disease (COVID-19), it is important to characterize CD8+ T cell epitopes in the SARS-CoV-2 peptidome that can trigger adaptive immune responses. Here, we use RosettaMHC, a comparative modeling approach which leverages ex... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A potent neutralizing nanobody against SARS-CoV-2 with inhaled delivery potential
### Response:
| The outbreak of COVID-19 has emerged as a global pandemic. The unprecedented scale and severity call for rapid development of effective prophylactics or therapeutics. We here reported Nanobody (Nb) phage display libraries derived from four camels immunized with the SARS-CoV-2 spike receptor-binding domain (RBD), from w... |
### Instruction:
Please summerize the given abstract to a title
### Response:
An AAV vaccine targeting the RBD of the SARS-CoV-2 S protein induces effective neutralizing antibody titers in mice and canines
### Response:
| The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in catastrophic damage worldwide. Accordingly, the development of powerful, safe, easily accessible vaccines with long-term effectiveness is understood as an urgently needed countermeasur... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction
### Response:
| Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a co-receptor with the ACE2 protein for recognition of the S1 spike protein on SARS-CoV2 virus, revealing an attractive new target for therapeutic intervention. Clinically-used heparins demonstrate relevant inhibitory activity, but world suppl... |
### Instruction:
Please summerize the given abstract to a title
### Response:
A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants
### Response:
| The emergence of antigenically distinct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increased transmissibility is a public health threat. Some of these variants show substantial resistance to neutralization by SARS-CoV-2 infection- or vaccination-induced antibodies, which principally targ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
SARS-CoV-2 variants exhibit increased kinetic stability of open spike conformations as an evolutionary strategy
### Response:
| SARS-CoV-2 variants of concern harbor mutations in the Spike (S) glycoprotein that confer more efficient transmission and dampen the efficacy of COVID-19 vaccines and antibody therapies. S mediates virus entry and is the primary target for antibody responses. Structural studies of soluble S variants have revealed an in... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Computational insights into differential interaction of mamalian ACE2 with the SARS-CoV-2 spike receptor binding domain
### Response:
| The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causing agent of the COVID-19 pandemic, has spread globally. Angiotensin-converting enzyme 2 (ACE2) has been identified as the host cell receptor that binds to receptor-binding domain (RBD) of the SARS-COV-2 spike protein and mediates cell entry. Bec... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Relationship between monomer packing, receptor binding domain pocket status, and pH, in the spike trimer of SARS-CoV-2 variants
### Response:
| Existence of a SARS-CoV-2 spike protein trimer form with closer packing between monomers when receptor binding domains (RBDs) are all down, locked as opposed to closed, has been associated with linoleic acid (LA) binding at neutral pH, or can occur at acidic pH in the absence of LA binding. The relationship between deg... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Comprehensive and systemic optimization for improving the yield of SARS-COV-2 spike pseudotyped virus
### Response:
| Virus neutralization assay is principally conducted by measuring the ability of the antibodies in patient sera to prevent the infection of susceptible cells by the virus As SARS-CoV-2 is classified as a risk group 3 pathogen, neutralization assay using a live virus needs to be handled in a biosafety level 3 laboratory ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Immunogenic SARS-CoV2 Epitopes Defined by Mass Spectrometry
### Response:
| SARS-CoV-2 infections elicit both humoral and cellular immune responses. For the prevention and treatment of COVID19, the disease caused by SARS-CoV-2, T cell responses are important in mediating recovery and immune-protection. The identification of immunogenic epitopes that can elicit a meaningful T cell response can ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Temperature effect on the SARS-CoV-2: A Molecular dynamics study of the spike homotrimeric glycoprotein
### Response:
| Rapid spread of SARS-CoV-2 virus have boosted the need of knowledge about inactivation mechanisms to minimize the impact of COVID-19 pandemic. Recent studies have shown that SARS-CoV-2 virus can be disabled by heating, the exposure time for total inactivation depending on the reached temperature (e.g. more than 45 min ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
### Response:
| The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directs infection of the lungs and other tissues following its binding to the angiotensin-converting enzyme 2 (ACE2) receptor. For effective infection, the S protein is cleaved at two sites: S1/S2 and S2′. The “priming” of the surface... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Assessing the impacts of mutations to the structure of COVID-19 spike protein via sequential Monte Carlo
### Response:
| Proteins play a key role in facilitating the infectiousness of the 2019 novel coronavirus. A specific spike protein enables this virus to bind to human cells, and a thorough understanding of its 3-dimensional structure is therefore critical for developing effective therapeutic interventions. However, its structure may ... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Structural Definition of a Neutralization-sensitive Epitope on the MERS-CoV S1-NTD
### Response:
| Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into the human population in 2012 and has caused substantial morbidity and mortality. Potently neutralizing antibodies targeting the receptor-binding domain (RBD) on MERS-CoV spike (S) protein have been characterized, but much less is known about antibodie... |
### Instruction:
Please summerize the given abstract to a title
### Response:
The nuts and bolts of SARS-CoV-2 Spike Receptor Binding Domain heterologous expression
### Response:
| COVID-19 is a highly infectious disease caused by a newly emerged coronavirus (SARS-CoV-2) that has rapidly progressed into a pandemic. This unprecedent emergency has stressed the significance of developing effective therapeutics to fight current and future outbreaks. The receptor-binding domain (RBD) of the SARS-CoV-2... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Targeting SARS-CoV-2 Spike Protein/ACE2 Protein-Protein Interactions: a Computational Study
### Response:
| The spike glycoprotein (S) of the SARS-CoV-2 virus surface plays a key role in receptor binding and virus entry. The S protein uses the angiotensin converting enzyme (ACE2) for entry into the host cell and binding to ACE2 occurs at the receptor binding domain (RBD) of the S protein. Therefore, the protein-protein inter... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Author Correction: SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects
### Response:
| An amendment to this paper has been published and can be accessed via a link at the top of the paper. |
### Instruction:
Please summerize the given abstract to a title
### Response:
In silico identification of linear B-cell epitope in Coronavirus 2019 (SARS-CoV-2) surface glycoprotein: A prospective towards peptide vaccine
### Response:
| BACKGROUND: The 2020 Coronavirus pandemic continuing spread of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) At the moment, there is no specific antiviral treatment or monoclonal antibodies or vaccines available for COVID-19 SARS-CoV-2 is positive-stranded R... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike
### Response:
| Binding of the spike protein of SARS-CoV-2 to the human angiotensin-converting enzyme 2 (ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the spike protein are heavily glycosylated, including at sites near their binding interface. We built fully glycosylated models of the ACE2 r... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Computational study of the furin cleavage domain of SARS-CoV-2: delta binds strongest of extant variants
### Response:
| We demonstrate that AlphaFold and AlphaFold Multimer, implemented within the ColabFold suite, can accurately predict the structures of the furin enzyme with known six residue inhibitory peptides. Noting the similarity of the peptide inhibitors to polybasic furin cleavage domain insertion region of the SARS-CoV-2, which... |
### Instruction:
Please summerize the given abstract to a title
### Response:
The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech)
### Response:
| The newly identified coronavirus SARS-CoV-2 is responsible for the worldwide pandemic COVID-19. Considerable efforts have been devoted for the development of effective vaccine strategies against COVID-19. The SARS-CoV-2 spike protein has been identified as the major antigen candidate for the development of COVID-19 vac... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention
### Response:
| A novel human coronavirus (CoV) has been identified as the etiological agent that caused the severe acute respiratory syndrome (SARS) outbreak in 2003. The spike (S) protein of this virus is a type I surface glycoprotein that mediates binding of the virus to the host receptor and the subsequent fusion between the viral... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease
### Response:
| Despite the introduction of public health measures and spike protein-based vaccines to mitigate the COVID-19 pandemic, SARS-CoV-2 infections and deaths continue to have a global impact. Previously, we used a structural design approach to develop picomolar range miniproteins targeting the SARS-CoV-2 spike receptor bindi... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Assessing Antigen Structural Integrity through Glycosylation Analysis of the SARS-CoV-2 Viral Spike
### Response:
| [Image: see text] Severe acute respiratory syndrome coronavirus 2 is the causative pathogen of the COVID-19 pandemic which as of March 29, 2021, has claimed 2 776 175 lives worldwide. Vaccine development efforts focus on the viral trimeric spike glycoprotein as the main target of the humoral immune response. Viral spik... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis
### Response:
| The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and performed in silico molecular docking with neuropilin-1 (Nrp1), a receptor–ligand intera... |
### Instruction:
Please summerize the given abstract to a title
### Response:
Computational studies evidenced the potential of steroidal lactone to disrupt surface interaction of SARS-CoV-2 spike protein and hACE2
### Response:
| The critical event in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is recognition of host cells by the virus, which is facilitated by protein-protein interaction (PPI) of viral Spike-Receptor Binding Domain (S-RBD) and Human Angiotensin Converting Enzyme 2-Receptor (hACE2-R). Thus, disrupti... |
End of preview. Expand in Data Studio
- Downloads last month
- 2