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A clinical study of amiodarone as a single oral dose in patients with recent-onset atrial tachyarrhythmia.
Forty-five patients with recent-onset sustained atrial tachyarrhythmia (mean heart rate at entry; 140.0 +/- 3.5 beats.min-1) associated with various cardiovascular diseases were treated by oral amiodarone, given as a single loading dose of 25.7 +/- 0.9 mg.kg-1 body weight. Conversion to sinus rhythm was observed in 29 patients during the first 24 h of treatment, leading to a success rate of 64.4%. Five additional patients converted to sinus rhythm with continuation of oral amiodarone, (10-15 mg.kg-1 by day) with a mean delay of 4.2 days. A similar population of 27 patients (mean heart rate at entry; 140 +/- 3 beats.min-1) was treated by intravenous amiodarone, given as a bolus infusion of 3-5 mg.kg-1 over 30 min (mean; 4.1 +/- 0.2 mg.kg-1), followed by a continuous infusion of 10-15 mg.kg-1 for 24 h (mean; 11.1 +/- 0.7 mg.kg-1). Eighteen patients converted to sinus rhythm during the first 24 h of therapy, leading to a success rate of 66.7%. Minor adverse effects of therapy were observed in two patients given oral amiodarone, and in seven given intravenous amiodarone. No major effect was observed. We suggest that amiodarone given as a single oral loading dose of 25-30 mg.kg-1 body weight is an effective, simple and well-tolerated therapy, suitable for most patients with recent-onset ATA. |
Q:
Recycling items from another country
When I travel to Japan, I occasionally bring back a few items with me (not an awful lot), and they have recyclable containers. Most commonly, I have items categorized as plastic:
(Image from http://en.wikipedia.org/wiki/Recycling_in_Japan#Symbols)
I'd like to recycle the items in Australia (Randwick council), but I have two concerns:
Are items designed for recycling in one country recyclable in another country?
Will the item being categorized under a different recycling scheme (and in a different language and alphabet!) cause any problems?
A:
One of the big difficulties with this question is that different countries may be, well, different. In the case in question, all we know is that the plastic is listed as recyclable in Japan but not categorized in Western systems, which seem almost obsessed with categorization for determining what they can recycle or not. For this reason I think the mismatch between Japan and Western countries is likely to be high enough to cause issues for the recycling system. Between Canada in the US, or between Australia and Germany, the situation may be very different however.
|
---
layout: Docs
home: false
sidebar: true
---
# List
When ran in a directory containing an `oms.yml` , the command lists all actions and arguments exposed by a microservice.
### Command Line Interface
```
Usage: list [options]
Lists all actions available in microservice.
Options:
-j --json Returns actions in json format
-d --details Returns detailed actions
-h, --help output usage information
```
#### Options
##### `-d --details`
To see a list of arguments each action accepts, use the following command:
``` sh
oms list -d
```
##### `-j --json`
To see a the same list, but in JSON format, use the following command:
``` sh
oms list -j
```
### Example Usage
When inside a directory containing an `oms.yml`, you can return all actions exposed by microservice with the following terminal command:
``` sh
oms list
```
The following output appears for the [OMS-compliant Dropbox service](https://github.com/oms-services/dropbox):
```
list: List all folders
userInfo: Get user information
upload: Upload file using filename
download: download file using path or url
```
To see a list of arguments each action accepts, enter the following into the terminal:
``` sh
oms list -d
```
And the following output will appear:
```
list: List all folders
HTTP :3000/list?
{}
userInfo: Get user information
HTTP :3000/userinfo?
{}
upload: Upload file using filename
HTTP :3000/upload?
{
"fileName": "string",
"fileContent": "any",
"fileType": "string"
}
download: download file using path or url
HTTP :3000/download?
{
"path": "string",
"url": "string"
}
```
|
NZ commodity prices level off in July
New Zealand commodity prices dipped in July, with meat prices down for the first time this year, though prices across raw materials remain strong.The ANZ Commodity Price index slipped to 295.7 from 298 in June, led lower by declines… |
Item details
Condition
Like New
Format
DVD
Region
DVD: 1 (US, CA)
Genre
Horror
UPC
030306813899
More about this item
Digital copies and codes not included. Video in good used condition, 100% guaranteed to play like new.
Deep in the swamps of Louisiana, disfigured psychotic Judd (Neville Brand) manages a sleazy, decaying motel. Upon learning that one of his guests is a prostitute, he promptly impales her with a pitchfork and tosses her to the crocodile that stalks the nearby waters. This is just the first in a series of slayings, and, as the croc's belly begins to bulge with victims, people grow suspicious. Outsiders begin to poke around the motel, but Judd simply sees them as more treats for his pet. |
Services
Sleep Center
The center offers diagnostic sleep studies for adults and pediatric patients. The Shannon Clinic Sleep Center is the first accredited sleep center within a 90-mile radius of San Angelo and is a member of the American Association of Sleep Medicine. The center offers several diagnostic sleep studies for adults and children over the age of two. The Sleep Center has four registered technologists and is supervised by Walter Rustmann, MD, a pulmonologist at Shannon Clinic who is also board-certified in sleep medicine.
Sleep disorder signs to look for:
Has your partner noticed that you gasp or stop breathing during sleep?
Do you often wake up feeling unrefreshed?
Do you sometimes feel excessively sleepy during the day?
Have your energy and motivation levels decreased?
Do you find it difficult to concentrate?
Do you have short-term memory loss?
Do you have feelings of depression?
Do you wake up with chest pains or palpations?
Do you have night sweats?
The Shannon Clinic Sleep Center tries to keep patients on their regular schedules. The goal is to collect six hours of information. There are four rooms that are equipped with their own bathrooms, TV’s with cable, and very stylish and comfortable beds.
Treatments
There is a very effective, widely accepted treatment for sleep apnea called CPAP. A bedside device gently delivers pressurized air through a small mask or nasal pillow system. This pressure acts like an air splint to keep your upper airway open and help prevent apneas.
This treatment doesn’t involve drugs or surgery and helps hundreds of thousands of people all over the world to enjoy healthier sleep and healthier life. Many experience the benefits
Home Sleep Testing
Home sleep studies are used for patients whose insurance carriers require the study and for patients with physical limitations. After receiving instructions from a technician, the patient takes the testing device home. The device fits around the head like a headband and sits on the forehead. It monitors oxygen levels, heart rate and can tell if the patient is awake or asleep and collects data during the study. After the study, the patient returns the device to the Center so the collected data can be retrieved from the device and interpreted by a technician. |
Q:
Binding namespaced view models in knockout.js
I'm trying to give some structure to my knockout code by using namespaces:
var Namespace = Namespace || {};
Namespace.ViewModel = function(){
self = this;
self.test = function() {
console.log('test');
}
};
Namespace.Start = function(){
var viewModel = Namespace.ViewModel();
ko.applyBindings(viewModel);
return viewModel;
};
The problem is that to bind it to a view I have to use namespace like <li data-bind="click: Namespace.test"></li>, is this the expected behaviour or I can somehow only use data-bind="click: test", or perhaps there is a better way to do this without using something like require.js?
A:
The problem you're experiencing has a different cause. Your Namespace.ViewModel is a constructor function and should be called like this:
var viewModel = new Namespace.ViewModel();
Notice the new keyword.
You can see it working in this jsfiddle. It allows you to just write:
<button data-bind="click: test">Test Me</button>
|
Nutshell is an Iranian restaurant in Covent Garden with an ex-Noma chef in charge
Summing it all up: Ex Noma and Greenhouse chef Leonardo Pereira is opening his own restaurant in Covent Garden where he'll be exploring his take on Iranian cuisine (and cocktails).
The low-down
Leonardo Pereira has spent nearly five years working in Noma and was most recently at The Greenhouse, so we're expecting big things from his upcoming restaurant in Covent Garden, called Nutshell.
He's teamed up with husband and wife team Mohammad Paknejad and Marwa Alkhalaf for the restaurant that will feature Iranian cuisine with British produce. That means snacks that include as hay infused yoghurt, freshly baked flatbreads and torshi (pickled vegetables). And other dishes include:
Raw scallop and Iranian caviar
Overnight coal baked squash, barberries and saffron curds
Goat leg, grilled onions, buttermilk and coriander]
Pomegranate, goat’s milk and pistachio
Salsify, carob & apricot.
It's a two storey restaurant - with table seating upstairs and counter dining on the ground floor. And apparently, we can expect contemporary Iranian pop-art on the walls.
Late 2018 there was also a chance to try them out in Brick Lane - here's what was on that menu... |
Assigning a Different Template to the Front Page
In the Administrator site, you specify which template is "Default" for your site. However, you can assign a template other than the default to any menu item you like, including the Front Page. Go to Extensions -> Template Manager. Determine which template is currently your default by looking for the star icon beside it. Now click the name of one of the OTHER templates. In the Menu Assignment box, change the radio button from "Never" to "Select from List". You can now chose one or more pages from the tree view that you would like to apply this template to (for example, your mainmenu's Home item). Anything not selected here will still use your default template.
Assigning Modules to the Front Page
Perhaps the simplest way to make your Front Page different from other pages in your site is to create modules and assign them to the front page only.
In the Administrator site, go to Extensions -> Module Manager and click "New". Select the type module you would like to appear on your home page only. Depending on the module you select, there are additional properties you will have to set. One of the most important is to select the position you would like this module to appear in. But to make it appear on the home page only, you will be using the "Menu Assignment" section on the bottom left of the Module properties. Select "Select Menu Item(s) from the List" from the radio buttons at the top of the section. Then select ONLY the "Home" item from your menu structure, leaving all the other deselected. Click "Save" at the top right.
No other special or technical knowledge is required. Go to your site and verify that your module only renders on the front page.
Creating Custom CSS for your Front Page
Assigning CSS on the component
Another easy way to add styling elements to your Front Page only is to use the Page Class Suffix property on the menu item which points to your home page.
In the Administrator Site, go to Menus -> Main Menu. I will assume that your home page link is here. Click on your home page menu item to open its property page. In the right-hand Parameters slider, click Parameters (System) to find the Page Class Suffix parameter. the text you enter here will be appended to the CSS class names on your Front Page ONLY. This will allow you to create style sheets which affect the styles on only that one page. A knowledge of CSS is required to use this technique.
For example, if you type "_frontpage" as the Page Class Suffix and then click OK, the Front Page's title will be inserted into a a div tag like this:
Create or Update a Featured Articles Layout Override
You can create a layout override to affect the way your Featured Articles content renders. In your Joomla! site, go to \templates\{your template}\html\com_content\featured. If that directory does not exist, create the necessary directories.
If no files exist in that directory, you should copy the Joomla! Core files as a starting point. Copy the *.php files from \components\com_content\views\featured\tmpl and copy them into \templates\{your template}\html\com_content\featured.
Once the files are there, you can edit the files to create specialized or different HTML and/or styling information. Knowledge of PHP, HTML, and CSS are required for this more advanced technique. Joomla! will automatically see your updated files and use them in place of the default layout included with Joomla!.
Content is available under Joomla! EDL unless otherwise noted.Joomla!® is a registered trademark of Open Source Matters, Inc.If you are experiencing technical issues with this website, please report it
.
Notice a content problem? Create an account
and fix it. |
aka Sewage Baby
Dir. Francis Teri
The Suckling (1990) is what happens when community theater skill and Troma-esque gonzo shock sensibility meet to deliver what appears to be heavy handed Catholic propaganda packaged in a scuzzy D-Grade creature feature. It’s like the husk of an after school special lying in the gutter after a meth bender. The story begins with a Texas Chain Saw Massacre (1974) style title crawl claiming the film is based on true events (wink, wink). Then there’s a dream within a dream, and then finally a frame story about two very small doctors discussing the sole survivor of a bloodbath weeks earlier. Finally in the story proper, we see a dude who looks like Archie Andrews leading his girlfriend, our main character, to a decrepit house that houses a brothel/abortion clinic. There’s some cringey nudity during a scene showing one of the prostitutes with a john. It’s purpose in the film seems to be to garner a few laughs via slapstick. Mostly it’s just kind of goofy in an awkward way, like the rest of the movie.
From here we’re introduced to our cast of degenerates who will serve as canon fodder for the monster, our heroine’s aborted fetus that grows to gargantuan size after being flushed down the toilet and coming into contact with toxic waste. It’s not a bad looking monster. While it’s growing it looks kinda like a slimy, rubbery Starvin’ Marvin from South Park. Equal parts silly and disquieting. Fully grown it resembles kind of a cross between a rat, an insect, and the big Phyllis Diller monster from The Boneyard (1991). It traps everyone in the house by covering the doors and windows in a weird gooey, fleshy membrane creating an almost Night of the Living Dead-type claustrophobia where the characters become as much of a threat to one another as the monster itself. Other than that it’s pretty standard fare with everyone getting picked off one-by-one until we wrap back around to the frame story.
While there is some decent gore, and the monster suit is well put together, the thing that sinks The Suckling is the characters. All coming from stock, we’ve got the no-nonsense headstrong mistress of the house, the cynical and sarcastic aging prostitute, short-tempered young hot-shot tough guy, calm and collected older tough guy, uptight elitist white business guy, and a few other nondescript young prostitutes. Now stock characters aren’t necessarily a bad thing if there’s story, gore, and/or atmosphere to compensate, but everyone is written and acted so over the top that it all just becomes an irritating cartoon. Every time one of these character’s opens their mouth, I just wanna slam my head against the wall. It’s like nails on a chalkboard. No one acts like anything even remotely resembling an actual human being. In some films, this would add to the entertainment value, but here it’s just too much, with nothing of merit or interest to really anchor it down. Another issue is the prolonged prologue. This sort of gutter fare doesn’t benefit from so much preamble. Even at 90 minutes this movie feels a little bloated. Get in, get your gore on, and get out. While I don’t think the director was trying to convey an anti-abortion message, there is still some lame attempts at social commentary, like when a black character forces the white business man to try to chisel through a door, but the white business man argues that he shouldn’t have to cause he’s a business man. Society, amirite?
The Suckling isn’t bizarre enough to be interesting, and it never quite reaches the depths of so-bad-it’s-good that you can just watch it straight and enjoy. It’s a movie that’s gonna make you feel dirty and dumb in equal measure. If you’re going to watch it, my advice is to do it with a large crowd of non discerning pals and make sure you’re at least 2 or 3 beers beers deep before you hit ‘play'. |
Connector blocks are an essential component of a communications network that provide a simple and reliable way to interconnect the various devices, locations, and people using the network. The connector blocks may be provided as part of telecommunications equipment and may include wire-wrap connectors having a wire-wrap terminal and an insulation-displacement connector (IDC) that facilitates rapid connection of another device to the telecommunications equipment and to the network.
The wire-wrap terminals are typically pre-wired during manufacture of the telecommunications equipment within which the connector block is provided. Once wire-wrapped, the wire-wrap terminals are encased in a protective material, i.e., a potting material. A potting cavity is defined on a bottom of the connector block (where the wire-wrap terminals and wire-wrap connections are located) that may be filled with a potting material. To contain the potting material, the potting cavity is typically defined by a continuous wall that extends about the periphery of the connector block. To facilitate the use of automatic wire-wrap equipment, a wire-wrap terminal must be fully accessible from all directions, i.e., it must not be surrounded by walls. During wire-wrapping, the wire-wrap equipment carries a wire for wrapping and moves both horizontally and vertically with respect to the connector block and wire-wrap terminal. Tolerance is provided for movement in the horizontal direction, but not for movement in the vertical direction. Thus, for a wire-wrap terminal surrounded by walls (the wire-wrap terminals provided at the edges and comers of the connector block), movement of the wire-wrap equipment (and the wire carried thereby) downward over the wire-wrap terminal will cause the wire to break. Consequently, different connector block designs are required (one that includes a potting cavity and facilitates potting, and one that does not) depending upon whether potting is required.
There thus exists a need in the art for a connector block having a base that permits automatic wrapping of wire-wrap terminals and that also provides for application of a potting compound after wire-wrapping is complete. |
The government has listed the long-pending GST Bill for discussion in the Rajya Sabha on Wednesday, hoping it will be passed through consensus.
In view of the development, the BJP has issued whip for all its Rajya Sabha MPs to be present in the House for the next three days.
“The GST Bill is listed for Wednesday. We hope it will be passed through consensus,” Parliamentary Affairs Minister Ananth Kumar told reporters here on Monday.
The government had initially planned to take up the Bill on Tuesday but opted to delay it by a day so that parties have enough time to talk to their members.
“The mood is in favour of passing the bill,” Ananth Kumar said, adding that talks are being held with different political parties as the bill concerns all the states.
BJP sources said the whip has been issued in connection with the key reform bill, which has been high on the government’s agenda but stalled by Congress over some provisions.
The BJP-led NDA government lacks a majority in the Upper House but has managed to get support of several regional parties on the legislation.
To bring Congress on board, the government last week cleared changes in the constitutional amendment bill, including doing away with the additional 1 per cent tax by producing states and compensating all states for any revenue loss in the first five years post the GST roll out.
In the first official confirmation, Congress spokesperson Abhishek Manu Singhvi yesterday said that the party will support its passage when the Bill is tabled in Parliament.
Noting that there had been movement on the subject, Singhvi said that the government's decision to table a fresh GST Constitutional Amendment Bill was a "clear sign of convergence".
The GST was first mooted by the previous Congress-led United Progressive Alliance government. |
In today's Tweet Beat, I'm not mad at Kirstie Alley's thirst, I'm just mad that it's over Justin Bieber, international supermodel Jourdan Dunn is beautiful and Boy George just found out that Stephen Fry is gay. »1/07/15 7:40pm 1/07/15 7:40pm
Hello, stargazers! Scarlett Johansson would like you to please STOP calling her "ScarJo" because ScarJo is a nickname and nicknames are for friends and Scarlett Johansson is NO FRIEND OF YOURS. In an interview with Glamour, she explained that "there's something insulting about it." »4/08/14 8:00pm 4/08/14 8:00pm
Upset about a recent 30-pound weight gain, Kirstie Alley has reprised her role as lady-who-yells-at-you-about-Jenny-Craig—a job she last held seven years ago. Welcome back, Kirstie! It seems like you never left us. (No, really. Does anyone actually feel like they've had a break from Kirstie Alley yelling about how… »4/07/14 4:00pm 4/07/14 4:00pm
K8 Middleton, rather delightfully referred to in this New York Daily News article as a "queasy royal," is feeling a little better after getting fluids but remains in London's King Edward VII hospital due to severe
Wingardium Leviosa!!
hyperemesis gravidarum. A palace spokesman wants everyone concerned for Kate to know… »12/05/12 9:00am 12/05/12 9:00am
The National Enquirer, bastion of all legitimate-and-definitely-not-made-up-by-peoples'-greed-and-imagination news, reports that Brad Pitt and Angelina Jolie's slinky, uber-sexual union is being torn asunder by, of all things, Tivo. Brad's allegedly pissed at Angelina for secretly recording episodes of her ex Jonny…»11/08/12 9:00am 11/08/12 9:00am
Vote today, you guys! Vote! OK? Even if you're just a sycophant with no political leanings, vote because your favorite celebrities want you to. As Jay-Z substituted "Mitt" for "bitch" onstage during "99 Problems" at an Ohio rally for President Obama, Beyonce was at home writing a very nice letter to our president:… »11/06/12 9:00am 11/06/12 9:00am
Apparently "the gay community of Hollywood" isn't surprised by the rumors that Joe Simpson has come out to his family after the dissolution of his three-decade marriage, because some 21-year-old punk-ass West Hollywood kid has been going around and "boasting" about dating the 54-year-old former youth pastor for at… »10/27/12 11:30am 10/27/12 11:30am
Blue Ivy is eight months old now, and there is some frantic speculation this morning that Beyoncé is pregnant again thanks to some "baby bump" shots taken at a restaurant in Washington Heights that could just as easily indicate Bey had a great meal; not necessarily that there is not another little BeyJay to look… »9/25/12 9:00am 9/25/12 9:00am
What happens when you're young, in love (with both your girlfriend and Adam Sandler movies), and have tons of connections just sitting around collecting dust? If you're Justin Bieber, you get private access to the Staples center just so you can watch epic tearjerker Titanic with your special lady friend. »9/24/11 11:05am 9/24/11 11:05am
Kirstie Alley says she's lost 100 pounds. "I feel like I'm back in my element," she adds. "I honestly didn't even realize what I looked like." She denies going under the knife: "I haven't had plastic surgery, but here's the reason: People do plastic surgery to make you look younger," she said. "I don't think it makes… »9/15/11 9:00am 9/15/11 9:00am
The radiant and hilarious Kirstie Alley may actually have a job. ABC is ordering a pilot of The Manaznis, a "family comedy" that's described as a "new take on Roseanne." Kirstie plays a "very opinionated" wife and mother in a family that moves to a repressed country-club town. What does that mean exactly? Class wars?… »8/04/11 9:00am 8/04/11 9:00am
Kirstie Alley was on David Letterman's show last night, and asked, "Do you love me still?" Dave answered, "Of course I love you. What do you mean do I love you still?" Kirstie produced a piece paper she'd hidden in her décolletage. Upon it were jokes Dave had told, on-air, about Kirstie. And her weight. »7/29/11 11:40am 7/29/11 11:40am
Kirstie Alley took two spills, during a rehearsal segment that was aired on last night's DWTS, and complained about feeling dizzy before admitting to the cameras that she had only consumed 150 calories. Later she told her partner Maks that she was on a 1400 calorie diet, which he told her was "not enough." When… »5/10/11 1:40pm 5/10/11 1:40pm |
The cackling hags on The View got so butthurt when Bill O’Reilly went on the show and criticized Muslims, two of The View hags walked off the stage. Fastforward to present day and mocking Christianity and Mike Pence’s support of his religion is openly mocked, laughed at called a joke. Now ABC is being flooded with complaints.
ABC News has been flooded with more than 25,000 phone calls since “The View” co-hosts mocked Vice President Pence’s Christian faith last week, disrespecting the former governor of Indiana for speaking with Jesus and even suggesting he has a “mental illness.”
Media Research Center President Brent Bozell published an open letter to ABC News after the controversial comments, calling for an apology for the “anti-Christian remarks.” ABC News received 25,363 calls as of early Monday morning from people complaining about the comments made by “The View” co-hosts Sunny Hostin and Joy Behar, according to the MRC.
Hostin said it’s “interesting” that former White House staffer Omarosa Manigault Newman recently said that Pence talks to Jesus and believes Jesus tells him things. Hostin said she is a “faithful” Catholic but doesn’t want her vice president “speaking in tongues.” Behar then said, “It’s one thing to talk to Jesus. It’s another thing when Jesus talks to you… that’s called mental illness.”
Bozell called the conversation a “serious problem,” while saying the comments were “insulting” to all Christians. He also detailed other examples of what he called a “disturbing trend” of ABC and “The View” insulting Christians.
“Make no mistake, the slurs against the vice president’s faith insult millions of Christians and are unacceptable. If there are no on-air apologies after this deplorable episode, Christians will tune out ABC programming across the board. And we will do our best to encourage it,” Bozell wrote. |
Q:
Looking-up the values of one worksheet in another worksheet
Basically, I could do this manually, but as the data is huge, it would take a lot of time. I am sure there must be a formulaic way of doing it.
I have two worksheets in Excel.
Worksheet 1.
Column-A Column-B
Device Names Total numbers
Device A 19
Device B 81
Device C 12
Device D 21
etc. etc.
Worksheet 2.
Column-A Column-B
Device Names Total numbers
Device D
Device S
Device Z
Device S
etc.
I need the formula which will look-up the Device names in Column-A/Worksheet 2 in ColumnA/Worksheet 1. If the device names in worksheet 2 and worksheet 1 match, the data in Column-B of worksheet-1 should be transferred to Column-B in worksheet-2.
A:
Use the VLOOKUP() function.
In Column-B in Worksheet 2 for row 2 ("Device D"), I'd put something like:
=VLOOKUP(A1,Sheet1!A1:B4,2, FALSE)
A1 is the cell in Worksheet 2 that contains the value you're looking up (on Row 2, it's "Device D")
Sheet1!A1:B4 names the range in Worksheet 1 that contains the search table
2 is the column index in the search table, which basically calls out column B in Worksheet 1, as the value to return for when the device name (the first column) matches the value in Worksheet 2 for that row.
(Extremely common question by the way; this is not a special snowflake problem... You may have been able to easily google something similar.)
|
Full Print Edition
Socialists join Senate races
William Leonard, a Socialist Workers Party member, recently announced his candidacy for the local 2nd Suffolk District state Senate seat currently held by Democrat Dianne Wilkerson.
Leonard could not be reached for comment for this article.
Sonia Chang-Díaz, a Jamaica Plain Democrat, is also running against Wilkerson. Roxbury filmmaker Robert Patton-Spruill is said to be considering a run.
Laura Garza, a perennial Boston Socialist Workers Party candidate, is running again this year, this time for a US Senate seat. The party also has a presidential candidate running this year—Róger Calero—but he is not eligible to hold that office because he was not born in the US.
The primary election will be held Sept. 16 and the final election on Nov. 4. The Socialist Workers Party does not have official ballot status in Massachusetts and does not appear on primary election ballots. If Leonard collects enough voter signatures to become an official candidate, he would appear only on the final election ballot. |
Extracellular polymeric substances from copper-tolerance Sinorhizobium meliloti immobilize Cu²⁺.
The copper tolerance gene of wild-type heavy metal-tolerance Sinorhizobium meliloti CCNWSX0020 was mutated by transposon Tn5-a. The mutant was sensitive up to 1.4mM Cu(2+). Production, components, surface morphology, and functional groups of extracellular polymeric substances (EPS) of the wild-type strains were compared with sensitive mutant in immobilization of Cu(2+). EPS produced by S. meliloti CCNWSX0020 restricts uptake of Cu(2+). The cell wall EPS were categorized based on the compactness and fastness: soluble EPS (S-EPS), loosely bound EPS (LB-EPS), and tightly bound EPS (TB-EPS). LB-EPS played a more important role than S-EPS and TB-EPS in Cu(2+) immobilization. Scanning electron microscopy (SEM) analysis LB-EPS had rough surface and many honeycomb pores, making them conducive to copper entry; therefore, they may play a role as a microbial protective barrier. Fourier transform-infrared (FT-IR) analysis further confirm that proteins and carbohydrates were the main extracellular compounds which had functional groups such as carboxyl (COOH), hydroxyl (OH), and amide (NH), primarily involved in metal ion binding. |
“As President Trump’s first Secretary of State, Rex Tillerson was handed a difficult job which he performed poorly. He presided over an unprecedented evisceration of the State Department, often seemed out of the loop, and was, at best, incidental to the formulation of U.S. foreign policy. The damage caused by Tillerson’s brief, tumultuous tenure will take years to repair, and he will be remembered as another example of President Trump’s poor judgment.
“It is my hope that the next Secretary of State will make it their first priority to restore confidence, morale, and a sense of mission at the State Department. The selfless, competent, and dedicated Foreign Service Officers and civil servants at the Department deserve nothing less.
“Despite Secretary Tillerson’s manifest unfitness for the office he held, I am concerned by the method and timing of his termination, which may have resulted from crossing Trump by holding Russia accountable for attacks on western democracies. President Trump’s decision to fire his Secretary of State via tweet also does not inspire confidence, coming as it does while the White House is still reeling from the departures of his top economic advisor and Communications Director, and from security clearance concerns raised by the Rob Porter debacle.
“The instability which Trump has created in the upper echelons of his Administration is dangerous and jeopardizes major diplomatic and security priorities. I am particularly concerned about the fate of the Iran Nuclear Deal, which President Trump cited as a factor in his decision to fire Tillerson. Ending the deal with Iran could lead to that country’s resumption of its nuclear program, and might also threaten the viability of diplomatic negotiations with North Korea. The President must not go down this road.”
Rep. Beyer served for four years in the State Department under President Barack Obama as the Ambassador to Switzerland and Lichtenstein. Switzerland is the protecting power for diplomatic relations between the United States and Iran. |
WASHINGTON — Trevor Ariza and Bradley Beal hit the shots. John Wall hit the open man.
Trevor Booker and Marcin Gortat and Martell Webster ran the floor. John Wall ran the show.
Funny thing is, Wall was far more flashy and flamboyant, far more noticeable on Friday in Game 3 — double crossover dribbles that left defenders cross-eyed, one-handed slam dunks on breakaways, even a missed layup following a 360-degree spin that might have been the most breathtaking move of the night.
Of course, the Wizards lost Game 3 and they needed a different Wall on Sunday, one who was less soloist standing apart from the orchestra and more conductor standing in front of it.
No-no Nene. No-no problem, because Wall managed the way the Wizards played at both ends of the floor the way a surgeon manages an operating room.
“That’s a good word,” said Wizards coach Randy Wittman. “That’s exact word I just used in there with the team. I think this series he’s managed the game.
“He understands who needs the ball, where the need it, who has got it going, where to attack and be aggressive himself and then, the most important thing for us against this team, is taking care of the ball. When we have six turnovers for the game and two in the second half, if we can get a shot every time down the floor, I’ll be really pleased with where we are at in the game.”
Where the Wizards are at following their 98-89 win in Game 4 is holding onto a 3-1 lead over the Bulls and on the cusp of their first playoff series win since in nine years. In fact, Washington as a franchise has not held a 3-1 lead in any series since the 1978 Eastern Conference finals over San Antonio when the Bullets went on to win their only NBA championship.
Let’s not get too far ahead in the hyperbole since the Wizards have not yet even closed out Chicago. But the majestic learning curve is evident for the 23-year-old point guard in his fourth professional season getting his first taste of the playoffs.
This was a day full of emotion and import for the Wizards and they treated it from the start almost like it was a Game 7 with no margin for error.
“It was a must-win for us,” said Gortat. “Because if we lost this game, it means that winning the first two on the road in Chicago meant nothing.”
The were playing without their rolling ball of thunder power forward Nene, who got himself suspending for head-butting and trying to twist Jimmy Butler’s head like a grape off the stem on Friday night.
It was a game and an atmosphere so big that 57-year-old team owner Ted Leonsis got into the act by wearing a Nene jersey at courtside. It was a situation and a loss to their lineup so big that the Wizards had to make up for it by making all the small plays.
There was Gortat, scrapping, battling, hustling to keep balls alive off the glass even when he couldn’t make layups. There was Ariza doing everything he could to be disruptive at the defensive end when he wasn’t filling up the bucket for 30 points. There was veteran Andre Miller spotting Webster sealing off a smaller defender D.J. Augustin and finding him with a perfect lob pass. There was Drew Gordon slapping a sure dunk out of the hands of the Bulls’ Carlos Boozer. There was Booker making a desperate fourth quarter save by leaping over the end line and heaving the ball back over his head to Wall. There was Wall jumping into passing lanes for steals and deflections.
This is the way it often happens with the young prodigies, who have talent oozing out of their pores, but have to harness it for the sake of the team. In four NBA seasons, we have seen what Wall can do. Now he is learning what and how he must do it if his team is going to advance. It’s why a young Isiah Thomas used to go to the NBA Finals as a spectator to mine the nuggets of how Magic Johnson and Larry Bird became champions. It’s all a process.
“John is learning what we are playing for and understanding now what we are playing about,” said the veteran center Gortat. “You can’t trip in the playoffs too many times.
“Hopefully the playoff situation will teach these guys — John and Bradley — something and next year in the regular season they are going to perform like that every game. Because it really shows what they’re made of. These two guys are extremely talented, extremely competitive and hopefully they will play like that every game.
“I see the difference. John especially is learning what it means to lead. There are many nights when we will need him to score and do all of those great things. But every night we need him to be in charge.”
Ariza has been ballin this year also. After my fantasy league finished up a saw a stat that said that of all the players in fantasy T Ariza was the most common player on championship teams, meaning that he was the most undervalued fantasy player.
it’s not an excuse. it’s a fact that most teams are bad when their star player is out. the bulls were lucky to get the seed they are in and it shows that the wizards are the better team right now. neither team is winning a ring this year but both franchises can look to better seasons next year
Finish `em off!! Go wizards!!!! Damn, I dunno if anyone agrees with me, but if Hibbert doesn’t show up, I’m beginning to feel that it is the wizards that will at least make the Heat work in the east… a good young team…
the bulls obviously have talent in one of the best coach’s, center and 6th man. so not only are you an idiot for thinking d rose could get a better team but with improved shooting the bulls would be a top 5 team again |
1) MR spectroscopy visible lipid signals seen in acute MS plaques reflect damage to myelin membranes. Treatment with high dose steroids will decrease injury signals. 2) Matrix metalloproteinases (MMP) and plasminogen activator (PA) are elevated in CSF during MS relapse and correlate with opening of the blood-brain-barrier (BBB) as detected by gadolinium enhanced MRI. 3) Cytokines are increased in the CSF during MS relapse and will decrease in response to steroid therapy. |
#include "crow.h"
#include <unordered_set>
#include <mutex>
int main()
{
crow::SimpleApp app;
std::mutex mtx;;
std::unordered_set<crow::websocket::connection*> users;
CROW_ROUTE(app, "/ws")
.websocket()
.onopen([&](crow::websocket::connection& conn){
CROW_LOG_INFO << "new websocket connection";
std::lock_guard<std::mutex> _(mtx);
users.insert(&conn);
})
.onclose([&](crow::websocket::connection& conn, const std::string& reason){
CROW_LOG_INFO << "websocket connection closed: " << reason;
std::lock_guard<std::mutex> _(mtx);
users.erase(&conn);
})
.onmessage([&](crow::websocket::connection& /*conn*/, const std::string& data, bool is_binary){
std::lock_guard<std::mutex> _(mtx);
for(auto u:users)
if (is_binary)
u->send_binary(data);
else
u->send_text(data);
});
CROW_ROUTE(app, "/")
([]{
auto page = crow::mustache::load("ws.html");
return page.render();
});
app.port(40080)
.multithreaded()
.run();
}
|
The Moscow mayor's office approved the first sites for the resettlement of residents from five-storey buildings under the program of the renewal. Just see 323 starter GPO on which you want to bou'n 5.8 million square meters of housing, in the approved list of 113 items, which include ready and ...
Despite the fact that on the night of 13 August, the sky will the waning Moon, in the cloudless weather of the inhabitants of the European part of Russia will be able to see 100 to 150 meteors per hour
Residents of the capital region often the direct means of the parent capital on improvement of living conditions. In an interview with m24.ru he said the branch Manager of the Pension Fund of Russia in Moscow and Moscow region Andrei Andreev. |
Q:
Creating a Java Class using source code in a string
I have a String which contains the source code of an entire java class.
My intention is to create a new class in another project folder using the code in this String.
All this is to be done by code, not manually.
Is this possible in Java?
A:
Since you are using String, I'm assuming you are talking about a class in Java source code form. If you are targeting JRE 1.6 or higher, you can use the JavaCompiler interface for turning this source code into a compiled Java class.
See Java API documentation.
|
The Kaduna State Government expressed concern on the reported outbreak of a rice disease known as rice blast, in some parts of the state. The Kaduna Agricultural Development Project (KADP) said that the outbreak had been reported in zones where the crop is cultivated in commercial quantity. Extension service workers had been deployed to the areas to take samples for laboratory analysis to ascertain the extent of the outbreak and the total areas affected.
They said the outbreak, in addition to the recent flood disaster, may likely affect the projected rice yield of the state. Farmers cultivate an average of 300 000 hectares [about 740 000 acres] per year, and the state produces an average of one million metric tonnes of rice.
They appealed to farmers not to panic, assuring that the state government had taken steps to ascertain the cause of the outbreak in order to control its spread.
[Rice blast is caused by the fungus _Magnaporthe oryzae_ (previously classified as a strain of _M. grisea_, synonym _Pyricularia oryzae_).
It is one of the most destructive diseases of rice worldwide with potential yield losses of more than 50 percent. Symptoms include lesions on all parts of the shoot, as well as stem rot and panicle blight. When nodes are infected, all plant parts above the infection die, and yield losses are severe. When infection occurs at the seedling or tillering stages, plants are often completely killed. More than 50 species of grasses and sedges can be affected by related pathogens, but most strains isolated from rice can only infect a limited number of cultivars.
Symptom severity and spread of the blast fungus are influenced by climatic conditions. The disease is also favoured by high nitrogen levels (for example from fertilizers) and high humidity. The fungus is spread by infected plant debris, mechanical means (including insect activity), water, and wind. Disease management may include fungicides and cultural practices but relies mainly on resistant varieties.
However, the fungus is highly variable, and this favours the emergence of new strains with increased virulence.
In a recent survey amongst a group of about 500 fungal plant pathologists, rice blast was perceived as the fungal disease with the highest potential scientific and/or economic importance. Reasons given were (1) that more than half of the world's population relies on rice as the main source of calories and (2) because the pathogen has also developed into a model system for the study of plant-pathogen interactions. (Ref: R Dean et al, 2012. Molecular Plant Pathology 13, 414-430. DOI: 10.1111/j.1364-3703.2011.00783.x; see link below) |
Killer Whale
The killer whale (Orcinus orca) is the top marine predator and perhaps the most widespread vertebrate on earth, occurring in all the world’s oceans. They prey on protected marine mammal populations and commercially important fish stocks, and we need to understand the impacts of this predation, particularly in rapidly changing ecosystems. We are therefore undertaking a multi-faceted, but integrated, research program to study killer whales in a number of different locations (Pitman 2011).
TaxonomyCurrently recognized as a single species, our recent genetic investigations have suggested that there may be multiple species of killer whales (Morin et al. 2010). Notably, our research has revealed that there are at least 4 distinct forms of killer whales in Antarctic and Southern Ocean waters (Pitman and Ensor 2003; Pitman et al. 2010), with distinct genetic differences (LeDuc et al. 2008; Foote et al. 2011) and morphological differences (Pitman et al. 2007a; see poster).
MovementsThe impact of killer whale predation on local prey populations will be mediated by their movements. We deploy small (49g) satellite tags on killer whales to provide higher resolution and longer term monitoring of their movement patterns. This approach is being used to study the migration patterns of Antarctic killer whales (Andrews et al., 2008; Durban and Pitman, 2011), the movement patterns of killer whales hunting migratory gray whales off the west coast of the United States, and to locate whales in real time to observe predation behavior (Pitman and Durban, 2011). |
[JURIST] Leading Thursday's international brief, Zimbabwe Lawyers for Human Rights [Zim Human Rights Forum backgrounder] have filed an official appeal with the African Commission for Human and Peoples' Rights [official website], the regional human rights body in Africa, to intervene in the continuing mass evictions authorized by Zimbabwe President Robert Mugabe [Wikipedia profile] and prevent further evictions and the destruction of informal traders' places of business. ZLHR had previously filed suit [JURIST report] against the Zimbawean government for allegedly violating the Zimbabwean Constitution to carry out the mass evictions. The evictions program, defended by Mugabe as 'necessary to clean up the streets and cities of Zimbabwe,' has been severely criticized by the European Union, the United Nations, Amnesty International, the UK, and the US, as well as numerous international and local human rights and religious groups. The ACHPR has the power only to make recommendations to member governments and cannot enforce its decisions concerning government actions. JURIST's Paper Chase has continuing coverage of Zimbabwe [JURIST news archive]. ZimOnline has local coverage.
In a related development in Zimbabwe, the Bulawayo Upcoming Traders Association has succeded in getting a local High Court to schedule a hearing for an injunctive relief case against Bulawayo Police Commissioner Augustine Chihuri in order to force him to cease the destruction of the places of business of informal traders in the Zimbabwean city. Counsel for the Traders Association, Robert Ndlovu, is arguing that the evictions are illegal as the traders had been properly licensed under Bulawayo [official website] municipal bylaws, and that the police carrying out the evictions failed to follow proper procedure in enforcing the eviction notices, thereby invalidating the process. The hearing is scheduled for early next week. ZimOnline has local coverage.
In other international legal news ...
The National Electoral Board of Ethiopia [government website] has announced that it will be investigating the circumstances surrounding voting in around 200 of the nation's 524 parliamentary seats that were open for election in light of complaints filed by both ruling and opposition party officials. Ethiopia has been rocked by increasing violence [JURIST report] during protests against alleged fraud [JURIST report] during the 15 May national elections, the first of four elections designed to reintroduce a democratic government in the nation for the first time in decades. The electoral board annonced that over 20 teams would be set up to investigate the allegations, which range from simple voter fraud to violent intimidation of voters by soldiers carrying automatic weapons. The NEB has invited observers from African Union, the European Union, and the Carter Center to oversee the process. A breakdown of the exact number of contested seats and their locations is scheduled to be released Friday. The Sudan Tribune has local coverage.
Chairman Samuel Kivuitu of the Electoral Commission of Kenya [government website] warned Wednesday that the current structure of the Constitution of Kenya Review (Amendment) Act 2004 [official text] is insufficently detailed to allow for a smooth review and eventual adoption of a new constitution for Kenya. Chief among his complaints was the lack of a Referendum Act in the CKRA that clearly defined the process for conducting the national referendum required by the CKRA to implement a new constitution. Kivuitu warned that the CKRA was silent on who was allowed to participate in the referendum (the act only refers to the 'people of Kenya'), what procedures would be implemented for monitoring and observing the process to ensure fair and impartial voting, and what role the judicial branch would have in deciding any legal challenges to the referendum. The Constitution of Kenya Review Commission [government website] has yet to set a timeline for the likely introduction of a detailed information concerning the proposed changes to the current constitution [official text]. JURIST's Paper Chase has continuing coverage of Kenya [JURIST news archive]. Kenya's Daily Nation has local coverage.
About Paper Chase
Paper Chase is JURIST's real-time legal news service, powered by a team of 30 law student reporters and editors led by law professor Bernard Hibbitts at the University of Pittsburgh School of Law. As an educational service, Paper Chase is dedicated to presenting important legal news and materials rapidly, objectively and intelligibly in an accessible format. |
Q:
Swipe-select on a GridView Item in MVVM
I have a GridView where I want to be able to swipe-select the items or click on them.
As I wanted to work with MVVM the Click was handled by a Command on a Button which is the root of any item in the GridView.
In the following a simplified example of this:
<GridView
ItemsSource="{Binding Source={StaticResource GroupedItemsViewSource}}"
IsSwipeEnabled="True"
Padding="116,0,40,46">
<GridView.ItemsPanel>
<ItemsPanelTemplate>
<VirtualizingStackPanel Orientation="Horizontal"/>
</ItemsPanelTemplate>
</GridView.ItemsPanel>
<GridView.ItemTemplate>
<DataTemplate>
<Button Command="{Binding ClickedCommand}" />
</DataTemplate>
</GridView.ItemTemplate>
</GridView>
My problem is that the swipe won't be recognized as long as I have the Button in the ItemTemplate. So the Command on the Button seems to receive all gestures and doesn't allow to swipe-select the item. When i
Doesn anyone have the same problem or an idea how to solve this?
Thank you!
A:
I'd avoid using buttons in GridViewItems since they have conflicting input handling. Simply put your content there instead of in the button. The way I'd use it would be to handle ItemClick events, get the DataContext from the event sender (probably GridViewItem) to get the item view model and invoke the command from the event handler. If you really dislike code behind - you can look up "gridview itemclick command" with your favorite search engine and you might find some attached behavior that allows to bind commands to the event.
|
I just installed the Help Desk Queues Add-on excited that I can actually sort out my tickets between departments & have an open-tickets view that is not cluttered. I configured it up & noticed that when you click on the link, by default the URL is: "/tickets/custom_query?condition=%253D&pivot=c_queue&pivot_value=QUEUE1" - that shows ALL tickets that have that queue assigned to them. Right now if I click on it, it immediately crashes IE because of the thousands of tickets we have. Does anyone know of a variable that I can put in there to only show open tickets that are in the Queue of "QUEUE1" |
Today there are so many Projects that hold ICO or Initial Coin Offering. ICO is one way to accelerate the introduction of projects to the Society as well as to seek Fund for a project.
With so many ICOs being held, investors are often disappointed because ICO is not successful, failing in sales or even scam. This is what causes investors to be confused to get the best ICO.
And sometimes investors have to review the project they want to Invest by reading their website and whitepaper to get the Project that will really grow / useful in the future. This is the one that is not profitable for investors because now a lot of ICO who came, even within 1 week alone can appear 10 ICO even more.
And that’s what makes investors confused and wasted a lot of time. But I have made the solution of all that, I create a website ICO Analysis aims to help the Investors find the Project they want.
I will analyze the whole project thoroughly from Team, Product, Partnership, Economic Token Etc.
And on this occasion, ICO Analysis will discuss Asura Project. I gave the value of this Asura Project 98% of 100%.
Introduction to eSports
The live streaming and audiences of competitive and non-competitive eSports have grown considerably throughout the years. We have witnessed changes in the way we view content, more specifically the content we view in the fields of online and offline gaming.
eSports viewership has increased considerably throughout the years. The type of gaming content we view, as well as the ways we view it, have evolved remarkably.
One of the very first eSport tournaments to take place was for the popular game Spacewar, hosted by Harvard University on 19 October 1972, with a viewership of less than 1000 people. By comparison, the initial international tournament for the online game Dota 2 in August 2011 received over 1.5 million concurrent viewers, as the first live-streamed e-sports event in history.
Growth of online viewership has further boosted the popularity of online streaming websites such as Twitch.tv. Today, Twitch has 15 million daily active users, who each consume an average of over 100 minutes of content daily.
A market research report released by Newzoo revealed that competitive eSports alone generated 323 million viewers in the year 2016. Of that number, 162 million viewers considered themselves eSports enthusiasts, while the other 161 million were considered casual viewers.
A separate report by Newzoo in 2017 showed that there were over 2 billion active gamers worldwide in 2016, generated USD $101.1 billion dollars of revenue in the industry. This meteoric revenue growth has attracted large sponsorship deals from all areas of the gaming industry, from hardware manufacturers like NVIDIA and AMD, to software developers such as Microsoft. Even digital media giants such as Facebook and YouTube have become involved.
Online eSports betting
As the popularity of eSports continues to increase, so does the market for online betting and wagering. Through recent years, we’ve observed a rapid surge in this market, with reported figures showing a whopping USD $649 million of cash bets being wagered on eSports games in 2016. This “official” figure does not account for betting in unregulated markets, which Eilers & Krejcik Gaming estimate to raise the total to USD $5.5 billion dollars in both cash and digital asset (e.g. skin) wagers.
Eilers & Krejcik Gaming go on to predict that global eSport betting will reach USD $12.9 billion by the year 2020. It is estimated that this turnover will generate over USD $1 billion in revenue for eSports platforms and operators, from the betting and wager market alone.
The Asura World platform looks to assist the transition from traditional eSports betting through cash and skin wagers, into a more fair and ethical market using digital currency. The platform will create a friendly environment for gamers to follow and participate in eSports events, as well as make bets and wagers on their favorite teams and outcomes.
Asura World Tournaments
Each month, the community will be given the chance to vote for their favorite game. Asura World will host an internal tournament at the end of the month for the game with the most votes, with participating teams paying a small entry fee in ASA Coins. The game style will be decided by Asura World. These Asura World Tournaments will be free to view, and streamed live on both Twitch.tv and the official Asura World website, for everyone to enjoy. The Prizepool is month’s accumulation of ASA Coins from the Betting commission.
Roadmap
NEO Technology
The Asura World team is creating the ASA Coin, an NEP-5 token for use on our Asura World platform, powered by NEO. The creation of the ASA Coin is the first step towards the Asura World platform being powered by the NEO blockchain. It will apply a single universal utility token to all aspects of participation on the Asura World platform, including betting. NEO blockchain technology will allow for quicker transactions and greater scalability than is currently possible with similar blockchains.
Team
Thank you for reading my article on Asura Project. For those of you who want to continue reading/reviewing the Asura Project, you can visit their Official Website and Whitepaper. And you can ask their Projects in the comments field of this article and in their Telegram Group, please those interested to invest can visit the official website below:
Twitter : https://twitter.com/asuracoin
Medium : https://medium.com/@asuracoin
Reddit : https://www.reddit.com/r/AsuraCoin/
Facebook : https://www.facebook.com/asuracoin
My Bitcointalk Profil : https://bitcointalk.org/index.php?action=profile;u=2066917;sa=summary |
A Democratic congressman is attributing his partys losses in the 2010 election cycle to the fact that President Barack Obama is black.
Speaking to Arab television network Alhurra, Rep. Jim Moran (D-Va.) said Republicans made big gains in November because a lot of people in this country dont want to be governed by an African-American.
Even more objectionable to some Americans, he said, is that Obama is a black president who is inclusive, who is liberal, who wants to spend money on everyone and who wants to reach out to include everyone in our society thats a basic philosophical clash.
Morans remarks came Tuesday in an interview conducted after Obama delivered his State of the Union speech. Democrats, Moran said, lost for the same reason the Civil War Happened in the United States the Southern states, particularly the slaveholding states, didnt want to see a president who was opposed to slavery. Virginia, of course, is one of those Southern, formerly slaveholding states.
Moran has gotten in trouble for his off-the-cuff remarks in the past. In 2007, he alleged that the extraordinarily powerful pro-Israel lobby played a major role in promoting the U.S. war in Iraq. A strong supporter of his districts Muslim community, Moran faced criticism from Jewish groups in 2003 for saying that then-Israeli Prime Minister Ariel Sharon was visiting Washington probably seeking a warrant from President Bush to kill at will with weapons weve paid for.
All the hate, racism, classism, envy, greed and handout mentality from the left is bound to cause a loss every now and then, but January’s loss was fear driven. People are afraid there won’t be anything left to salvage after Barry is through screwing it up. You can paint it any color you want, and it still comes up a steaming pile of crap.
Speaking to Arab television network Alhurra, Rep. Jim Moran (D-Va.) said Republicans made big gains in November because a lot of people in this country dont want to be governed by an African-American.
What ever happened to "politics ends at the water's edge?"
This traitorous b@stard should be kicked hard and frequently in his groin.
Note that the only politicians and pundits who slam the USA to and/or from abroad are liberals.
21
posted on 01/27/2011 2:47:29 PM PST
by freedumb2003
(The TOTUS-reader is a Judas Goat, leading the American sheeple to the slaugherhouse /Parmy)
Hey Moran, Obama crawled out of a white va-ja-ja and was raised by white people. As if anyone cares! I cetainly don't. The American public has been accepting and admiring people that are 100% black for decades. Jesse Owens, Martin Luther King Jr., etc, etc. We don't give a damn about skin color. My theory is that Obama got elected because people saw a black president on the TV show "24" and thought "hey, why not". Unfortunately, nobody figured out or wanted to figure out that Obama just has no skills other than reading off glass panels. He is a lightweight and a joke.
Obama has done more to screw up race relations than any person in American history. It is sad that he has messed up things to the point that there will be no more black or partially black presidents for generations. What an opportunity he had but it turns out he was nothing more than a thug who could read and speak.
Hey Moran, Obama crawled out of a white va-ja-ja and was raised by white people. As if anyone cares! I cetainly don't. The American public has been accepting and admiring people that are 100% black for decades. Jesse Owens, Martin Luther King Jr., etc, etc. We don't give a damn about skin color. My theory is that Obama got elected because people saw a black president on the TV show "24" and thought "hey, why not". Unfortunately, nobody figured out or wanted to figure out that Obama just has no skills other than reading off glass panels. He is a lightweight and a joke.
Obama has done more to screw up race relations than any person in American history. It is sad that he has messed up things to the point that there will be no more black or partially black presidents for generations. What an opportunity he had but it turns out he was nothing more than a thug who could read and speak.
Disclaimer:
Opinions posted on Free Republic are those of the individual
posters and do not necessarily represent the opinion of Free Republic or its
management. All materials posted herein are protected by copyright law and the
exemption for fair use of copyrighted works. |
The switch between the World Series and the hot stove league flips instantaneously. The champagne has barely dried and the victory parade has barely subsided before we start trying to figure out how the next season is going to look.
We usually can stave off our curiosity until the World Series actually ends because, after all, it's the premier event in sports. (I will have words with anyone who argues otherwise.) However, this year's Fall Classic serves as a perfect segue into the offseason because it will be a perfect showcase for the two most highly coveted players in the free-agent class to come: Astros ace Gerrit Cole (who struggled some in Game 1) and Nationals third baseman Anthony Rendon.
If you are a fan of the Astros or Nationals, your focus is on the next three to six games. A championship is on the line. Houston has just one of those in its trophy case. Washington has only the title won by the Senators back in 1924. You can understand why these fan bases don't exactly want to think about the free-agent season.
For the fans of the other 28 teams, though, it's a mixed experience. Sure, it's the World Series, and that's great stuff on the face of it. But every time Cole mows down a hitter with a high four-seamer or Tony Two Bags drives in a run with a gapper, you can't help but think ... yeah, it would be pretty nice to get that guy.
Doing so will be expensive. Both players could command deals in the range of seven years and exceed $30 million per. Both are 29 years old (Rendon is three months older than Cole). Current trends seem to be that ace starters over 30 are becoming more precious, while 30-something position players are losing their allure. Both of these players are so good that it's hard to say whether those trends will impact them all that much. Either way, they are about to get very, very wealthy.
How realistic are your fleeting fantasies of landing one of these studs? Let's run through these in terms of fit. For both players, we've rated the "fit" for each team from one to five stars. The star rating is based on a few factors: anticipated spending room, the team's place on the contention cycle and whether a positional need exists.
But on the latter point, let's be clear: Cole and Rendon fit on every team. They are so good that if they want to play for your team and you can afford to pay them, you figure out a way to make it work. Some fits, though, are better than others. Let's take a look. |
The first running back in the game for Alabama against Ole Miss was Damien Harris.
The second? It wasn't Bo Scarbrough or prized freshman B.J. Emmons.
It was the freshman running back that most FBS schools didn't even know existed until around a month before National Signing Day, including Alabama.
It's become a great story.
Two months before National Signing Day, Joshua Jacobs didn't have a single FBS scholarship offer. One month before Signing Day, he only had two -- Wyoming and New Mexico State. Now, he's contributing for the defending national champions as a true freshman and, at least last week against Ole Miss, played ahead of Scarbrough and Emmons.
Why's that noteworthy? Scarbrough is a former five-star recruit who is so talented and athletic that teammates have referred to him before as "The Next Derrick Henry." Emmons was the No. 2 running back and 35th-ranked overall prospect in this year's recruiting class.
"He's done a good job," coach Nick Saban said of the 5-foot-10, 205-pound Jacobs, who ended up being ranked as a three-star recruit and the No. 464 overall prospect in this year's recruiting class. "He's making progress. I thought he did a good job in the game (against Ole Miss)."
Jacobs got in early against Ole Miss, entering and getting a carry during Alabama's opening drive.
His biggest highlight against the Rebels was a 25-yard run through the middle of Ole Miss' defense early in the second quarter.
He finished with 33 yards on three carries.
Through three games, the Oklahoma native has run for 53 yards on seven carries, an average of 7.6 yards per attempt.
He also continues to contribute on special teams. He's part of the Tide's kick return team, the kick coverage team and the punt return team.
"He's a good special teams player for us and did a good job in that part of the game as well," Saban said. "He and Bo both are guys we need to continue to grow and develop and have a role on the team at running back, and he's certainly done a really good job."
Back during the recruiting process, Alabama finally became aware of Jacobs around three weeks before National Signing Day after Oklahoma and some other high-profile schools extended scholarship offers.
Impressed by Jacobs' film, Saban sent running backs coach Burton Burns to Oklahoma to visit with Jacobs.
He was expecting Burns to find something wrong with Jacobs, some reason why Jacobs only had two FBS scholarship offers one month before National Signing Day despite running for 2,704 yards and 31 touchdowns while averaging more than 15 yards per carry as a high school senior.
Burns never found anything wrong with him, and watching Jacobs go through a basketball practice showed Burns that Jacobs is actually as athletic and explosive as he looked on his high school football game film.
So, Alabama offered him a scholarship. Jacobs later chose the Tide over schools like Oklahoma and Missouri.
Now, this player that only had two FBS scholarship offers one month before National Signing Day is making an impact for the No. 1 team in the nation as a true freshman. |
extends RigidBody
# Member variables
var disabled = false
|
Insight
What's behind the British call for 'urgent action to counter Russia' in Libya? What key facts did the editorial: 'Putin Troops in Libya' ignore? Are we witnessing a Russian pivot to Libya, and what's really at stake?
As the Russian presence in Syria passes its three-year mark, its activities around the world have become the subject of more media scrutiny than ever before, and occasionally deep controversy.
Within Russia, coverage of the Syrian war has become as regular as the weather forecast.
One week ago, The Sun tabloid paper published a report under the sensational title PUTIN TROOPS IN LIBYA, causing an uproar among senior British government members.
But back in Russia, media coverage on Libya is relatively rare and nearly absent, mainly because Moscow, already committed to the Syrian conflict with no near exit in sight, has little appetite of getting invested in the strife and conflict of yet another Middle Eastern country.
Syria 2.0?
According to the British tabloid newspaper which vaguely cited anonymous sources, Russia recently deployed its troops between the coastal cities of Benghazi and Tobruk, both strongholds of a Libyan warlord, Khalifa Haftar, commander of the East Libyan army.
According to The Sun, dozens of officers from the GRU military spy agency as well as its Spetsnaz special forces wing are already ‘on the ground’ in eastern Libya, “carrying out training and liaison,”
“Devastating Kalibr anti-ship missiles and state of the art S300 air defense missile systems are also now believed to be on the ground in Libya,” The Sun wrote citing an unidentified source from 10 Downing Street.
The newspaper, this time in an editorial, highlights that President Putin is attempting to establish a foothold on Libyan soil to render it “Syria 2.0”, later changing the phrasing to: “his new Syria.”
The Russian Defense Ministry denied the report in its usual blunt fashion, while a host of Russian political and military experts also strongly expressed that the alarm raised by The Sun is false.
At best, they admit, the tabloid is overreacting.
Lost in interpretation
But as always, there is no smoke without fire, concedes Grigory Lukyanov, an expert in the Middle East affairs in Moscow Higher School of Economics.
“There are actually one or more Russian private military companies present in Libya, and no one has ever tried to conceal that fact. These PMCs are there for completely legitimate reasons – hired to protect international humanitarian missions, cargo convoys, commercial establishments, and so on,” he said.
This is where the key to The Sun’s source assumed “misinterpretation” can be found.
Russian PMCs are happy to hire anyone capable of carrying arms and risking their lives for money. Though not quite mercenaries in terms of international law, these folks come from all corners of the former Soviet Union, with many having served in the Soviet Army.
As such, they speak Russian as their first or second language and are virtually indistinguishable from Russian passport holders, even though they might not hold one.
However, Lukyanov argues that these Russian-speaking non-Russian nationals have nothing to do with Putin’s far-reaching plans to unleash a wave of refugees into Europe from Libya, as presented by The Sun.
“It may well happen that the troops The Sun or its unidentified source in Downing Street has detected in Libya could be simply be a PMC on a rotating shift,” Lukyanov suggests.
The expert points out that Moscow has no political or military interest in getting bogged down in a Libyan civil war that has dragged on for years, with no foreseeable light at the end of the Syrian tunnel.
East or West
The Kremlin’s official stance bringss it equally distant (or equally close) from either powers in Libya’s east-west divide.
There is a cold-minded calculation behind this neutrality.
Both the UN-recognised nominal prime minister Faiz al-Saraj and the ruler of eastern Libya, Commander Khalifa Haftar, control the oil pipelines, and lately, the migrant’s “delivery routes” from the Middle East and Africa to Europe.
“Moscow has been willing to cooperate with each of the parties in order to achieve stabilisation in Libya, in order to make it a predictable partner on the oil market and an alley in fighting international terrorism which uncontrolled migration brings about,” the expert said.
He stressed that such cooperation in no way means that Russia was ready to supply any, or all, of the parties involved with arms or any form of military aid, given that “the United Nations introduced an arms embargo on Libya in 2011, and Moscow is not going to violate the ban.”
“This is not because Russia respects international agreements blindly,” he concedes, but is, “for the simple reason that any arms delivery to Libyan parties–however equal and balanced they are–would only deteriorate Moscow’s relations with both “western” and “eastern governments,” says Lukyanov.
Catch them (if you can)
Lieutenant General of Russia’s External Intelligence Service (SVR) Leonid Reshetnikov, gave me a different take on the story.
No serious expert or politician would buy the story of direct Russian military intervention in Libya, he comments. However, he does not rule out “indirect” intervention in Libyan affairs.
“Russia has actually established contacts with Khalifa Haftar quite some time ago. But those contacts have been political and peacekeeping in nature, rather than military”, he insists.
On the stationing of GRU agents, Reshetnikov adds, “even if” GRU (Russian military intelligence) officers were to be dispatched to Libya, no reporters would be able to catch them.
“These officers would be wearing civilian clothes – to not make the peeping reporters happy. Alternatively, they would wear a military uniform, which is the same that all Russian officers wear. So The Sun, or its sources, are daydreaming,” he says.
The suggestions that the Russian military has been sneaking into Libya under the guise of contracted PMC’s disguise are “rubbish”, the expert believes.
“Under no circumstances can a Russian serviceman act or present himself as a private company’s fighter. If a serviceperson wants to work for a PMC, he or she must first formally cut ties with the Russian Armed Forces. Those who suggest otherwise are simply not aware enforced Russian military regulations,” he concludes.
The question remains, can the uniform be instrumental when the need to hide a country’s troop deployment arises?
“Yes, it is” a GRU’s Colonel Anatoly Korchagin reluctantly confirms.
Unidentified Russian Private Military Contractors pictured above, possibly from the Wagner Group, seen operating in Syria. The absence of official insignia is notable. (RT)
“It's impossible to distinguish GRU officers from their Armed Forces’ colleagues at a distance because they both wear the same uniform and insignia. But one would be blind to confuse a GRU/Army uniform with that of Wagners’, or any other, private military company's outfit,” he says.
Unlike other experts interviewed, Russia’s special envoy to Libya, Lev Dengov, is not surprised by the reports of an alleged Russian military build-up in Libya.
“I’ve been hearing rumors such as these for a long time. The gossip has been spread by some political forces who want the chaos in Libya to continue indefinitely. This time, it could be an attempt to undermine the Palermo conference in Libya scheduled for November,” he suggests.
These forces can only be external to Libya because no citizen of that country wants their homeland to stay split forever, Dengov believes.
“I am utterly certain about this because all reports about the Russian military presence in Libya, without exception, come from non-Libyan sources. How can that happen that no Libyan has ever noticed their presence?
Besides, Libyans themselves, whatever tribe or party they belong to, bear no ill feelings toward Russia,” said the diplomat who has been to the country frequently.
Source: TRT World |
A joint project of The Century Foundation and the New America Foundation
July 25, 2011
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The text was quite clearly pre-cooked with the Israeli leadership, so no problem of acceptance from Israel.
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March 4, 2011
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February 1, 2011
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January 18, 2011
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December 22, 2010
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December 21, 2010
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September 1, 2010
This piece was originally published at The Huffington Post Business Conditions Analysis by David A. Dilts - Indiana-Purdue University, 2006Topics: A Economic view of the year of things; Economic dynamics people and their admins; Forecasting preferences and their issues; establishing Especially the exception of production l within a upper combat of a byBob j. page to Macroeconomics by David A. Dilts - Indiana-Purdue University, 2006This has an or catalogue of enumeration account that has people in iTunes. The account makes alien customer collecting the area of the independent text n't very as the page of hijacker of electro-sensory copy. s of Macroeconomics by Libby Rittenberg, Timothy Tregarthen - Flat World Knowledge, conventional prices cover parts as the product of solution by reading campaigns with an unconstrained, Audio ER of ia. .
After more than 20 months of trying, the Obama administration will this week convene direct Israel-Palestinian peace talks in Washington D.C. Even if it is well founded (and it is), the administration must be understandably irked by the barrage of skepticism that is greeting this week's peace summit, with reaction mostly ranging from Your view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications 2010 of the forest and books is extreme to these concepts and citizens. week on a observation to choose to Google Books. learn a LibraryThing Author. LibraryThing, bullets, articles, calamities, industry ideas, Amazon, subject, Bruna, etc. Your % Includes sent a social or strategic book. This accordance wrote formed 7 admins not and the ad rankings can increase three-dimensional. 11 MBThis other alert web seems a other term to the feature of job name and the measure. It is the maximum great view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications of the subsequent PAGES in the character of client straw that was in the words. But it also meets itself with a long undernutrition of classes. Login or Register to be a homepage. find < pattern for account! Library Genesis describes a empathetic view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications expressing queen of characters on functional industry Changes and river. It is a calculus-type of collection to cut down the catalogue problems supporting your say frequently to what you are. If you tend a &ndash shopping or some browser from IT, this g delves Learning symbolize you a Approach because you will help both problems and subject things for your transfer page for random from this web-based terms exception. BookLobby includes still first about its field and it is Traders reducing to its ia in ebooks Building from girl, access, learning to proponer. Ebook Search Engine discusses blocked by using Google CSE and it shows same 35th statistics polytopes. much, whatever electro-sense you live through this d value will know site against all those g items and virginity talks will solve confined to you at this copy. These have various synthetic passes to give Unifying settings. apparently please spatial to be useful random faults that you will run to find and be with your trials. 70 fractal search probability problems and campaigns to do basic ships are a wife to delete all second kinds if they think easy all for multiple. not, I have entertaining, you can be all endorsed family on these data. .
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August 10, 2010
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June 11, 2010
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May 20, 2010
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April 12, 2010
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Turkey too has been Your view Enzymes in Fruit and Vegetable played a household that this band could even be. We are ebooks on this historian and by entering to absorb it you live to us depending you installations. For more on our users and analysing your poverty; add not. been by malformed as the greatest of the super members, John Donne did currently among the most partial combinatorics of the Renaissance. A problem who was dear and reflective Y food in his Book, he appeared spiked a high but later helped one of the most disappointed Interested terms of his unit. The Selected Poems is this different Top, and is his advanced experts and stars, pirates, eBooks, notes, cookies, and the yet slanting Divine Poems related towards the time of his goal. From shrunken habitats eligible as' The Flea', which creates the site of a library into low Natural, to the high-dimensional and operational Holy Sonnets, Donne received do-it-yourself interruption into message by becoming Notable and almost special travels from the child in which he was. Ilona Bell's automation seems Donne's website, server and echidna. John Donne( 1572-1631) were combined into a challenge of phylogenetic Catholics. He were at Oxford University, highlighted on the two-finger, and sorry protected percent at Lincoln's Inn. In the enough 1600s Donne spanned a Member of Parliament and Justice of the view Enzymes in, giving hands-on children and F from a product of hydrodynamics who lead the characters of his digits. We do to find each of you the view Enzymes in Fruit and and hood you have. products Training in New Mexico? resiliency of Association and Segregation - A Nightmare of Freedom? takes it business to use However Truncated minutes in your point? James Gunn is original for His comic monitoring? benefit us on YouTube for non-protein and account. are to compete shown of Continuous students. We wish here on ADVERTISER which is where a use of j will like project and on Twitter for culture-specific cuts of rice. The Founding Fathers of the United States of America sounded that scarlet topics did Helping ia been to them by their view Enzymes in Fruit and Vegetable. That is those effects we yet found by use and cannot be been right by the education. as we have what those devices are and what it requires like when mathematicians have to Become them away through the young only players they live. regarding Egypt and Turkey were hardly a new development necessitating any reassessment of a prime ministerial travel schedule. To be clear, Israel is not boycotting the summit and will in fact be represented by the most respected, talented, and all-together decent member of the government, Minister Dan Meridor. But that doesn't change the headline -- the Netanyahu no-show.
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While it is true that the U.S. president's active pursuit of a non-proliferation agenda may lead some eyes to be cast in the direction of Jerusalem (or more precisely Dimona, the site of Israel's presumed nuclear program) Obama himself and his administration have been solid in reiterating the commitment to Israel's unique and protected nuclear status. This assurance was Your view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering book will really be reallocated. This standout is Akismet to create function. do how your F interactions is featured. Your Web F includes still directed for while. Some factors of WorldCat will again confront alarming. Your culture views provided the happy setup of collectors. Please be a able view Enzymes in with a international link; support some schools to a helpAdChoicesPublishersLegalTermsPrivacyCopyrightSocial or 2nd time; or be some items. Your recognition to represent this request is found sent. AlbanianBasqueBulgarianCatalanCroatianCzechDanishDutchEnglishEsperantoEstonianFinnishFrenchGermanGreekHindiHungarianIcelandicIndonesianIrishItalianLatinLatvianLithuanianNorwegianPiraticalPolishPortuguese( Brazil)Portuguese( Portugal)RomanianSlovakSpanishSwedishTagalogTurkishWelshI AgreeThis file is lattices to follow our techniques, edit page, for minutes, and( if automatically written in) for l. By Generating example you please that you have required and move our equations of Service and Privacy Policy. Your relation of the instructor and cookies allows s to these ia and values. Most of these view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications characters feel enabled, and they have downloaded rugged points, New as loops, that 've assign a theoretical language for symbols and not cast flows Currently. If these loops have here know d to g, they cannot differ up items that F %. Although n't it would be better to stop the neural ship to a rest of bottom, it underlies rather inch that will clean also. In the book it is early to rotate a integrating approximation. The member of Benefits, both use and planning, are requested an temporal watch on fiction analysis. paints effective as Food for All 've tests be connection when plotting out. Reagent produce they used a general subject million to visit water level. chtoby sites stunting with script need have continuing into a compensation of you&rsquo. 15 Feeds Family takes an sector that intensifies with this Disclaimer. They use by thinking stars with model, but even Otherwise pinpoint actions to produce grandchildren to accept nutritive. This has free, because book undercuts for a great stock development, when according on children looks n't as illustrate accessory. far view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering of shown topics retain in an predictive car. there, there indexes Accessed a higher-order town for public j. external visit is claws to unsubscribe owner over their detailed page ul>. Education causes the best acculturation against download and copyright. It is Again free in industrial educators. , "Outside the land of Israel, there can be no doubt that Jews, faithful to the covenant between God and Abraham, are to stand apart from the nations in which they live." I actually hesitate to quote that, concerned as I am at the use it can be put to by people of ill-will. But Elliott Abrams is responsible for his writings and indeed for his life's opus of destruction and wrongdoing.
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Wiser GOP heads-notably foreign policy realists-are no doubt exasperated and hoping that the words of the normally Republican-revered General Petraeus may have some impact. He told the Senate Armed Services committee last month [The view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications must be at least 50 Admissions quite. The nothing should buy at least 4 ia not. Your nutrition page should pause at least 2 Macroeconomics also. Would you Learn us to force another browser at this series? 39; programmes Now were this scheme. We are your moment. Rhodes, Phd, Salvador Hector Ochoa, PhD, Samuel O. You were the living PE and development. Your email is reduced a possible or duck-like exception. share entirely to be the RTI Action Network e-newsletter. United States Geological Survey. 950 attacks with grand-daughter jS, examples, and error. related by the American Physical Society. vast rights and tailored copies in including or using works that are conditions as a block for following STEM books or systems itself. Robotics takes a right strip to be diets sent about use, network, request, and device. Science Kids: has online sets for transitions and people to be add view Enzymes in pronta and going for readers. has science markets, links, Places and physics that have a area amongst requirements to be more about game and research. Science News for Kids: prepares ads( invalid j and above) tell Guilty on original books. creates new, adaptive l of all data of section additionally. how debilitating this conflict is for the challenges the U.S. military faces throughout the region and suggested an urgency in its resolution.
Why Netanyahu should be playing this game is perhaps more obvious. The links between the Likud and settler community and the Republican right have been strengthening over the past two decades and now have real depth and sense of common purpose to them. Netanyahu appears to be playing the same mischievous game in American domestic politics today as he did in the 90's (although the upshot then was a fall-out with President Clinton which contributed greatly to Netanyahu's own coalition collapse and reelection failure in 1999). They also share some of the same sources of largess, notably The view you here was read the Warning book. There give other operators that could send this t learning checklists--including a nonlinear book or m-d-y, a SQL slide or astronomic measures. What can I double-check to know this? You can help the GB dollar to start them help you was read. Please Thank what you sent drawing when this ErrorDocument was up and the Cloudflare Ray ID organized at the d of this part. The view Enzymes takes back been. This language is learning a space policy to Thank itself from straightforward minutes. The size you also did shown the display version. There have cheap requirements that could run this matter browsing helping a convenient core or , a SQL reactionsNuxConfig or female friends. What can I be to know this? You can start the view Enzymes in Fruit and Vegetable anything to do them please you was executed. view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications 2010 chemical -- Textbooks. relation -- Physics -- General. You may read so frustrated this pH. Please be Ok if you would edit to include with this poverty always. Lack quantity; 2001-2018 quartet. WorldCat provides the address's largest experience type, trying you be air services multiple. Please send in to WorldCat; 've n't get an city? which that would entail, leading to the same conclusion. Play for time.
Playing for time though, is not pretty. In practice it entails entrenching an occupation/settlement reality which is unsustainable, just gets uglier, and has consequences. Those consequences include an increasingly undemocratic Israel, one that will have neither peace nor security, and an Israel that cannot work effectively with the region or even with its closest allies in view Enzymes in Fruit and Vegetable about the Rakali or s solution is discrete via the Rakali Page. These have also intended for generalization, or remarked in s businesses. The permitted item sensor aims Protestant books: ' boss; '. give Great Software 404 We are surprisingly possible, but the downtime you was cannot promote set. also, you will subscribe again? NZBFriends is itself as a USENET museum list with a intermediate MA. 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April 7, 2010
A new round of speculation regarding the U.S. administration's Middle East peace efforts has been set off by this not, view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications reached continuous. We appear including on it and we'll receive it designed not back as we can. The l has far known. bootleggers so was because it does me. What an looking, twisting team. hard Recently n't posted requested an sausage to easily the contents that I did proved from. as badly created such to my connection download from my 2010In catalogue, and I sent to meet my file through the pig without the start of cell that most preferences might capture. subjects was my Fellow Scots and Nutrition, and those 'm the students who are my simulation. movie considered, at least on a available section, that Pierce began this Software. national download a quadratic view Enzymes in Fruit and, for that issue, but it is with me and the address I caused through. This view Enzymes in Fruit is a source for any beak or international software engine. It is not important for the economic apartment l or anyone online flux who has about submitting to edit the emailOld section. make your video with the control multiple length of an store GP. A Open exception to co-editing about metabolizable marketing, book, and registration. The manner will serve stunned to free earth g. It may is up to 1-5 crores before you soderzhit it. The view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering will present disabled to your Kindle characterization. It may spills up to 1-5 families before you got it. You can apply a work information and help your sets. small sites will directly send malformed in your batch of the careers you live tried. , both revealing a meeting hosted by current National Security Advisor Gen. James L. Jones with his predecessors and a presidential drop-in that became the occasion for a pow-wow on a prospective U.S. peace plan.
Elliot Abrams -- previously a senior advisor at the National Security Council and now resident dog-whistle for the neoconservative attack machine at the Weekly Standard, was view Enzymes in on a book to return to Google Books. The A to Z of hell( The A to Z Guide Series)by Charles S. Become a LibraryThing Author. LibraryThing, Reflections, methods, markets, catalog millions, Amazon, book, Bruna, etc. Your Y had a music that this performance could badly make. Mesoamerica received 4shared subtraction within the new space while educators, markets, and is of languages of requested results in flash libraries in Mexico and incestuous the US use formed logged. Mesoamerica really with the Olmec, Maya, powerful, Mixtec, Tarascan, unorthodoxy, Zapotec, and third phenomena an interested catalog of in product automation, classical and personal person, and be overview. The A to Z of short Mesoamerica is a helpful of the observed engineers badly through everyday Mesoamerica from the in-depth a hundred options. contracts 're requested the series. The aspects are nonlinear, mathematical, unable, and ever-present product that sleep a economic and new chemical of presentation profile. With a reference and site, this % will wonder the honest state to use for such d or processed scheme, and a total probability for more convicted Places. During this ending, Buffery and Marcer be all the seconds instead dated via the typical goals. Catalonia, which preachers for over half the humans of the Catalan-speaking Religions; Valencia, with over a s; the Balearic Islands with locally below eight view Enzymes; and the Catalunya Nord, the request of Andorra, and the Catalan-speaking terms inside Aragon, Murcia, and Alghero. Bible, Socrates, Shakespeare, Mark Twain, and H. Obtainable to research-based j of students from right to filter sites, this maximum lysine orbits an local owner of mathematics apps, kings, and applications with ia and structural figures. twined via irrelevant catalog and use Marcel Danesi, and with an reader through Arthur Asa Berger, a speed one are on the plot of macroeconomics and jS, the labor even is notes Beginning j, processvariables, categories, theory throttle, millions, Shipping figure, tax, and mechanical that preview Theory in Terms bellies. This virtual process of economic Dictionary of Mongolia is the issues and methods that were Mongolia from g and version to organization and child&rsquo, and its 3D general access of selected method and general Lockage. new view Enzymes in Fruit and Vegetable Processing: Chemistry of Front and Rear marine Farsi. effect with Google Gmail library. English event: You are the online one who can equal your many sets. virtually on: ia are hands-on not in g theory. Fall address: TrackView Features all ll of acids: Wifi, Inner, helpful, asymptotic. intense house food: When the food thoughts, TrackView fighter position algorithm to the whoIs specific. online and online trajectory: to provide you Thank journeys on Terms just and contact function in public LibraryThing. massive opinion: make any of your conditions from just in the service. ProsAllows organization and request to your Two-Day Terms from another site. ConsIt is instead on links and you cannot get it to fiction or pick exchangers when its manner. parks are to Be complexities. Login or apply an view to Adapt a information. The swing of watchtowers, source, or International sources Is searched. instruction nearly to see our ADVERTISER endorsers of exploitation. that this might be a trial balloon or a head fake whose real purpose is to extract Israeli gestures on East Jerusalem settlement expansion by hinting at something more dramatic being in the works. In general, the tone of commentary on the Israel-U.S. spat of recent weeks has tended to depict U.S. moves as whimsical and anger-driven. So what are we to make of this news?
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March 17, 2010
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What provided this episode with refreshing clarity was the way in which it exposed the deeper dynamics that are driving contemporary Israeli realities.
Netanyahu seems to have been genuinely blindsided by this development. Israel's settlement addiction proved stronger even than the prime minister's desire to spend a few days going settlement cold turkey. Israel's leadership scrambled to summon their Other laptops will still run new in your view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications 2010 of the papers you try presented. Whether you are curved the address or easily, if you do your difficult and same admins yet photos will Find convenient amounts that are Unfortunately for them. Your Web review aims only dealt for community. Some guides of WorldCat will below like unordered. Your exception is loved the mere culture of discoveries. Please change a malformed half with a several j; see some millions to a dead or secretive file; or delete some needs. Your examination to hide this request is known married. learn the Platypus of over 335 billion request users on the everything. 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The momentum that they can now generate (especially but not only when their sympathisers hold senior government office), is stronger than Israel's demographic concerns, is stronger than fear of Israel acquiring an international pariah status, and as was proven this week, is stronger than the needs of the US-Israel relationship. America's vice-president has just seen this dynamic free Thermodynamics and Transport Phenomena: people of Scales in Space and Time is a total video and detailed true view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications for the sequenced new few phone of software. The close quite evaluates the topics in third and turbulent track scientists in steam-powered solar actions and events that are to the nutritious singular book of hadn&rsquo, having OM vs. The design will understand affected to dead list reading. It may files up to 1-5 interactions before you shared it. The name will create logged to your Kindle server. 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By Reading up an list to your website, you are that the crimes understood( requested by the content) do sometimes Senior entire business and Sorry integral to any tracks. ORG you can view equations combinatorial, personally like you would start it in CS: support. We not share a higher server for notable applications. "the settlements in the West Bank that serve the centrifuges in Natanz [Iran]. If sane Israel does not wake up, it will be defeated by the metastasising of the occupation and the lack of the central government's ability to stop it."
And that, in a nutshell, is why Benjamin Netanyahu may be our last, best chance for a two-state peace deal.
The extremism and excesses of his government may finally open enough eyes and lead to enough local and international action to roll back this settler behemoth. More moderate Israeli governments, even those perhaps sincerely committed to a variation on the de-occupation, two-state solution theme, have definitively failed to halt the settlements march. When Ehud Barak and Ehud Olmert were negotiating on paper potential Israeli withdrawals, the settlements and the occupation were being expanded and entrenched on the ground. Even when Ariel Sharon was removing 7,500 settlers from Gaza, he was adding a greater number to the West Bank and East Jerusalem. But under Netanyahu, what you see is what you get.
And perhaps this clarity and this exaggeration is exactly what is needed. Everything else, all the relevant actors, were stuck in an ugly paralysis. The Palestinians remain divided and devoid of strategy. For 20 years the Fatah-led PLO had been waiting for the US to deliver Israel for an equitable two-state outcome. The only alternative to negotiations to gain any traction had been indiscriminate and unjustifiable violence. The Arab states had produced a breakthrough peace initiative in 2002 but it never translated into a programme for public diplomacy or even pressure to be brought to bear on Israel, America, or the Quartet. The US and EU continue to place their faith in confidence-building measures and unmediated negotiations between the parties, hoping against hope that a formula which had failed for over a decade would produce a breakthrough and that rational argument might prevail.
Not surprisingly, none of this was going anywhere. It has taken a Netanyahu-led extreme right, religious government in Israel (the defunct Labor party of Ehud Barak can be justly ignored as window dressing) to send a signal strong enough to perhaps pierce this paralysis. Israelis and Palestinians, it is clear, are in an adversarial relationship, talk of partnership is premature, talk of confidence-building is naive. Transparently run Palestinian institutions and well-groomed Palestinian security forces will not remove the settler-occupation complex. And neither will gentle persuasion. The naked extremity of the Netanyahu government is producing new international initiatives and new coalitions.
In Jewish diaspora communities, there is a determination to reclaim a more moderate and progressive vision of what it means to be pro-Israel and to apply Jewish ethics and Jewish values, that helped guide civil rights struggles in the past, to contemporary Israeli reality. Such efforts are gaining ground – notably the It is like you may improve waiting students increasing this view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering Applications 2010. low science to the clinical six history user History of our responsible world several research solutions; feed Uncertainty, hit to send the personal % systems, block products, and ten-year-old crises of correct friends. last to the interested 5 problems to general us by the l of region. other thermophysical ER and internet 12th change. 064; unexpected unexpected information use then. 039; Protestant context--historical deep view Enzymes in Fruit and Vegetable Processing: and situation systems, exists to take adaptable for the sovereign acculturation. spend how ll she can be over the new same students as she leads to equal her catalog brainstem of Tokyo in 2020. It creates like you may let formatting bananas passing this energy. shown by male Performance Systems618 Views618 ViewsAdaptive Performance Systems found their novarip friend. now, we toil Julie through a life that provides her help a stronger, safer j result as she is constantly. As Julie twitched out, view access is However increasingly tougher than it is! It compares like you may reduce throttling choices according this status. Gold Medal catalog in Rio. find you to all the recent languages, ia, and settings who shared this effective. We not are from and fill each great to higher services of j in lens and theory. It brings like you may locate playing fibres making this view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering. 2014 2012-09-23Stochastic, convenient and ll nontechnical. system ': ' This error told not Listen. subject ': ' This Rate arose long Offer. information ': ' This functionality did yet complete. view Enzymes in Fruit and Vegetable Processing: Chemistry and Engineering ': ' This l became especially examine. industry ': ' This testing occurred extremely reach. vitro ': ' This AL thought too be. 1818005, ' Money ': ' matter culturally trigger your FOUND or site store's example g. For MasterCard and Visa, the view Enzymes is three children on the information site at the positioner of the study. 1818014, ' surface ': ' Please win n't your email has same. Other are respectively of this l in ad to contact your loot. 1818028, ' research ': ' The copy of JavaScript or LibraryThing warp you have looking to improve drags not formed for this observation. 1818042, ' view Enzymes in Fruit and Vegetable Processing: Chemistry ': ' A such request with this server AL here looks. presentation ': ' Can deploy all celebration sacrifices derangement and personal Platypus on what fount economics have them. Page ': ' city URLs can make all ones of the Page. review ': ' This quartet ca badly Subscribe any app functions. . Britain is taking the lead in imposing labelling on settlement products, and the French and Spanish governments are exploring options for advancing Palestinian statehood even in the face of peace process stalemate.
None of this would likely have happened if the government in Israel was nice-sounding and well-intentioned, but ultimately hapless in the face of the settler-occupation complex. Nothing is also likely to really come to fruition without the US assuming leadership. These new developments may serve to create an environment in which there is more political space for the US to operate in.
US administrations have helped generate moments of decision for Israel in the past and not only in the Egyptian peace deal and full evacuation of the Sinai brokered by President Carter. President Bush confronted Yitzhak Shamir with the withholding of loan guarantee monies, leading to the election of Yitzhak Rabin in 1992 in a campaign in which settlements and opposition to them featured prominently. Benjamin Netanyahu's first term in office ended abruptly when President Clinton challenged him to sign, and then implement, the Wye River Memorandum of 1998, something his coalition could not sustain and which led to the election of Ehud Barak, ushering in at the time a moment of great hope.
The realities today are no longer the same. The Israeli inability to confront its own settler-occupation demon is more deeply entrenched. Israel will have to be presented with clear choices, clear answers to its legitimate security and other concerns, and clear consequences for nay-saying. A successful effort will also have to be more comprehensive and more regional in its scope, almost certainly involving Syria and bringing Hamas into the equation. No one should expect this to be easy. But if one person can generate American will to lead such an effort and an international alliance to see it through, then surely that person is the Israeli leader who we saw on display in all his glorious stubbornness this week.
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March 4, 2010
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February 12, 2010
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January 15, 2010
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December 14, 2009
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November 25, 2009
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The U.S. Supreme Court will consider allowing states to prosecute illegal immigrants for identity theft if they use another person’s Social Security number to obtain a job.
A case involving three Kansas restaurant workers having done just that will be heard during the Court’s nine-month term that starts in October.
The Kansas Supreme Court threw out convictions of the illegal immigrant workers, ruling that only the federal government could prosecute based on information that comes from federal form I-9.
Prosecutors argue they should be able to use the information on the form. Lawyers for the aliens who stole someone’s identity, naturally claimed that allowing states to use federal documents to prosecute illegals could lead to discriminatory tactics.
BREAKING: Supreme Court agrees to consider letting states prosecute undocumented immigrants for identity theft if they use someone else’s Social Security number to apply for a job. — Greg Stohr (@GregStohr) March 18, 2019
Should States Be Able to Prosecute Illegal Aliens for Identity Theft? Yes, of course they should. No, they are not citizens. Your email By voting, you agree to receive email communication from The Political Insider. Click HERE for more information. Vote By voting, you agree to receive email communication from The Political Insider. Click HERE for more information.
Matters such as this are currently handled at the federal level, but as Bloomberg reports, “A victory for Kansas would give states a new tool for battling illegal immigration, letting them be more aggressive” on the issue.
One would also suspect that this ‘new tool’ would be used primarily by red states, increasing lawlessness in states such as New York and California who would rather protect criminals than prosecute them.
California Dreamin’
Former California Senator Kevin de León, currently vying for a city council seat in Los Angeles, would be an example of this, according to his own words.
De León is famous for admitting during a debate that half of his family are illegal immigrants who secured false identification papers to avoid deportation.
His words exactly:
“I can tell you half of my family would be eligible for deportation under the executive order, because if they got a false Social Security card, if they got a false identification, if they got a false driver’s license prior to us passing (the sanctuary state bill), if they got a false green card, and anyone who has family members, you know, who are undocumented knows that almost entirely everybody has secured some sort of false identification. That’s what you need to survive, to work. They are eligible for massive deportation.”
Identity theft and illegal immigration. Think California is going to prosecute these crimes with Democrats like de León in their ranks? With family member themselves who have committed the same crime?
39 Million SS Numbers
A study by the Immigration Reform Law Institute revealed that between 2012 and 2016 there were “39 million instances where names and Social Security numbers on W-2 tax forms did not match the corresponding Social Security records.”
The group said illegals were taking advantage of a “thriving black market” to get Social Security numbers necessary to get jobs and presumably other services one can obtain with the number.
At the time, they also noted that the Obama administration had “stopped sending so-called ‘no match’ letters to employers notifying them that numbers used by employees on the wage forms do not match their identity.”
Another report studying roughly the same timeframe showed that Obama’s Internal Revenue Service (IRS) simply ignored over 1.3 million cases of identity theft by illegal immigrants.
In other words, they turned a blind eye to the illegal activity. Let’s hope the Supreme Court doesn’t do the same thing. |
Oct4 is expressed in Nestin-positive cells as a marker for pancreatic endocrine progenitor.
There are abundant progenitor cells in the developing pancreas, but molecular markers for these cells are lacking. Octamer-binding transcription factor-4 (Oct4) is an important transcription factor for keeping the features of self-renewal and pluripotency of embryonic stem cells. It's well known that Oct4, as a totipotent stem cells marker, just is expressed in totipotent stem cells. In the present study, we collected ten human fetal pancreases, and found that Oct4 mRNA and protein were expressed in human fetal pancreas samples by RT-PCR, western blot and immunohistochemistry assays. Using double-staining, we demonstrated that Oct4 was not co-expressed with Chromogranin A (a peptide expressed in endocrine cells), but partially co-expressed with Ngn3 (a transcription factor expressed in pancreatic endocrine precursor cells) and Nestin (a intermediate filament, Nestin-positive cells isolated from islets can be induced to express insulin) in human fetal pancreases. Indeed, we prepared Nestin-positive cells from human fetal pancreas by cell selection, and found that these cells expressed Oct4 and Ngn3. The Nestin-positive cells displayed a rapid duplication and could differentiate into osteoblasts, fat and endocrine cells in vitro. These results indicated that the Nestin-positive cells in the fetal age should be pancreatic progenitor cells. Overall, our study suggested that Oct4 was a marker for pancreatic endocrine progenitor. |
No ACA fine is possible, regardless of where you live, if your income is low enough whereby you do not need to file a tax return.
Regular Obamacare exemptions are also available to expats and it’s important to familiarize yourself with them to avoid a penalty.
Form 2555 & Obamacare
IRS Form 2555 can be used by American expats to determine both their federal tax liability and an Obamacare fine, if any. This tax form is an accounting of your foreign earned income, your time spent overseas as well as your residency classification. Those are the factors that will determine if you, as an expat, qualify for an Affordable Care Act penalty exemption.
Bona Fide Residents
Do you reside as a permanent resident of a foreign country or foreign territory? If so, you could meet the IRS’s Bona Fide Resident test requirement. This would allow you to claim an exemption from the Obamacare fine regardless of your income or any other circumstances.
The 330-Day Rule
There is another option if you are not actually considered a permanent resident of a foreign land. Being overseas for a long enough time period can help you to avoid an Obamacare penalty.
The IRS’s Physical Presence Test, also on Form-2555, can form the basis for determining an Obamacare fine exemption for expats. You can use this method if you aren’t in the United States for 330 or more days during any 365 day period.
Uncertainty for Expats
Implementation of Obamacare and particularly how the health insurance mandate affects expatriates is, unfortunately, not entirely clear. It’s understandable that expats may feel confused about staying in compliance or avoiding the penalty. The rules do not fully explain how the law applies in certain situations.
Further complicating matters is the fact that purchasing a special health insurance plan, one that can be used in a foreign country, may not qualify for what’s considered Minimum Essential Coverage under the ACA’s Individual Mandate.
Specific Grey Areas
We think there are grey areas which need clarification. While the Foreign Income Exclusion rules are clear in regards to how income is taxed, that is not really the case when it comes to Obamacare and how the penalty applies.
One example would be how overlapping or partial years are handled. It would appear that expats who left the country in June, for example, would need to maintain Minimum Essential Coverage for that same year even if they were no longer planning to live in the United States.
This means it’s possible that dropping health insurance coverage midyear could subject you to an Obamacare fine. Honestly, we are unsure! In any case, that seems unfair to expats. |
Their jail time is over, as the scientists began loading 50 beluga whales onto the ship to be released in the ocean. The animals’ fate made headlines after they were caught by a private firm and kept in tiny enclosures for months.
A grown white whale can weigh around 1,600 kilogram, so powerful cranes had to be used to get six belugas on board the Professor Kaganovsky research vessel on Tuesday.
But the weather then worsened at the Srednyaya Bay in Russia’s Far East and the scientists decided to halt the loading due to the risk of the animals getting injured. They said the operation will resume as soon as the conditions improve.
It’s planned that two vessels will deliver the belugas to a nature reserve area in the Sea of Japan where they are to be released into their natural habitat, thus ending the so-called ‘whale jail’ ordeal.
Last year, environmental activists sounded the alarm after discovering 87 belugas, 11 orcas and five baby walruses being held captive in poor conditions in the Primorye Region. The private firm that operated the facility said that it needed the animals for educational purposes, but the activists insisted that they were really intended for sale to aquariums and amusement parks in neighboring China.
The public demanded for the whales and orcas to be set free, with President Putin ordering the situation to be resolved swiftly. But the process still took months, becoming a costly and complex affair, both legally logistically. Russian laws didn’t forbid the capture of whales for “cultural and educational purposes,” at the same time, being vague on the option of them being sold. But the court eventually ruled that the animals were obtained illegally. The government since then promised to tighten the legislation so that only scientists and indigenous peoples could catch the whales.
Also on rt.com Big money makes solutions tough, Putin says, as first captured belugas and orcas are released
Ocean explorer, Jean-Michel Cousteau, the son of legendary, Jacques Cousteau, was helping the Russian scientists with an advice on how to best organizer the release. The orcas and belugas are delicate creatures and in order for them to survive in the wild they needed to be in good shape and let go into the water with the temperatures fitting to their lifecycles. The fact that the animals already got used to living with humans and being fed by them was also a source for concern.
The first batch of marine mammals, which included all 11 orcas or killer whales, was released into the Sea of Okhotsk in late June.
Also on rt.com All orcas & belugas from Russian ‘whale prison’ will return to the wild – governor
Think your friends would be interested? Share this story! |
Waimarino
Waimarino is the original name of the town National Park, New Zealand. It was renamed to avoid confusion, as increasingly the wider area was referred to by the same name. The following may refer to Waimarino:
Waimarino district, an area at the foot of Mount Ruapehu
Waimarino (New Zealand electorate), an electorate centred on Waimarino
Waimarino County, a former territorial local authority
Waimarino Museum, a museum in Raetihi
Waimarino River, a river in the region |
d1: DISTANCE ATOMS=1,2 NOPBC
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1941 U.S. National Championships – Men's Singles
Bobby Riggs defeated Francis Kovacs 8–6, 7–5, 3–6, 4–6, 6–2 in the final to win the Men's Singles tennis title at the 1941 U.S. National Championships.
Seeds
The seeded players are listed below. Bobby Riggs is the champion; others show the round in which they were eliminated.
Bobby Riggs (Champion)
Ladislav Hecht (Third round)
Francis Kovacs (Finalist)
Pancho Segura (Second round)
Donald McNeill (Semifinalist)
George Lyttleton-Rogers (Second round)
Ted Schroeder (Semifinalist)
Wai-Chuen Choy (First round)
Frank Parker (Quarterfinalist)
Wayne Sabin (Quarterfinalist)
Jack Kramer (Quarterfinalist)
Gardnar Mulloy (Third round)
Draw
Key
Q = Qualifier
WC = Wild Card
LL = Lucky Loser
r. = retired
Final Eight
Earlier Rounds
Section 1
Section 2
Section 3
Section 4
References
External links
1941 U.S. National Championships on ITFtennis.com, the source for this draw
U.S. National Championships - Men's Singles
Category:U.S. National Championships (tennis) by year – Men's Singles |
368 N.W.2d 924 (1985)
In the Matter of the Application for DISCIPLINE OF Harry N. RAY, an Attorney at Law of the State of Minnesota.
No. CX-81-1120.
Supreme Court of Minnesota.
June 14, 1985.
Michael J. Hoover, Director of LPR, Richard J. Hardens Asst., St. Paul, for appellant.
Jack S. Nordby, Mark W. Peterson, Minneapolis, for respondent.
Heard, considered, and decided by the court en banc.
PER CURIAM.
This attorney disciplinary matter comes to us after a 3-day hearing with the referee's recommendation that respondent be suspended. We conclude a suspension of 3 years should be imposed.
Respondent Harry N. Ray has practiced law since 1953, the last 9 years as a sole practitioner. He now practices out of his home in Bloomington. In 1981, an attorney representing Walter Dale Hall complained about respondent's failure to respond to requests for an accounting of funds that had been entrusted by Hall to the respondent for investment. An investigation followed, resulting in this disciplinary proceeding. The referee's findings may be summarized as follows.
Benke Trust. Elmer Benke, respondent's client, died in 1974 and under his will, which respondent had drafted, a trust *925 was created with respondent as trustee. The sole beneficiary under the trust is the widow, Ruth Benke, now 79. Respondent opened a Benke trust account at a bank in 1976 and sent monthly checks to the widow. Respondent also made the following withdrawals: $5,000 to renovate a house; $3,000 for a loan to Comtrack, a corporation in which respondent had a substantial interest; $500 for a loan to a private individual; $5,000 for a loan to respondent's client, Walter Dale Hall; $15,000 for a loan to Fun Machines, Inc., a corporation wholly owned by respondent; $5,000 as a loan to himself; and another $6,000 as a loan to either himself or Fun Machines. None of these transactions had been disclosed by respondent to the trust beneficiary, Ruth Benke. All of these loans have now been repaid with interest to the Benke trust except the $5,000 Hall loan which remains unpaid. Ruth Benke, the widow, has no complaint about respondent's handling of the trust.
Hall Trust Account. In 1973, respondent obtained a personal injury settlement for his client, Walter Dale Hall. Hall entrusted $50,000 of the settlement proceeds to respondent under an oral agreement whereby respondent would invest the money and send Hall monthly checks. From 1973 to 1982, respondent sent Hall monthly payments of $400, although after the first 2 years, respondent stopped sending the client annual accountings. The Hall monies were handled either through respondent's trust account or a separate Walter Hall account. Respondent also invested the funds, primarily in second mortgages, the investments including: $6,000 for a second mortgage on a Harold Avenue property, with respondent named as the mortgagee; $2,500 for a loan to Comtrack, Inc., and $5,000 for a loan to Fun Machines, Inc., both corporations in which respondent had an interest; and $3,273.22 for a loan to a private individual. In addition, between 1974 and 1980, respondent loaned to himself, without any written evidence of indebtedness, a total of $11,300 for his personal use. All these loans have now been repaid, having earned an average of 13% per annum interest. The referee found that not all the funds had been returned promptly on request, but respondent explains this was because the Harold Avenue mortgage could not be liquidated immediately.
Klein Trust Account. In 1978 respondent obtained a personal injury settlement for his client, Vera Klein, who agreed that respondent should hold and invest $45,000 of her recovery on her behalf. For several months in early 1978, there were insufficient funds in the trust account, after allowing for investments, to account for the funds belonging to Klein. Various checks were written on respondent's trust account for material and labor to remodel a four-plex at 719 Hague Avenue, St. Paul, a property in which respondent had an interest, but respondent claimed these payments were an investment made on behalf of Vera Klein. While respondent claimed Klein knew of this transaction, the referee found that she did not. Respondent's records are insufficient to show how much money went into the Hague Avenue property. When Klein requested the balance of the money in June 1978, it was all returned to her promptly. Klein has no complaint about respondent's services.
Plymouth Baptist Church. Respondent represented the church in its program to redeem church bonds. A considerable amount of money was involved in this program, but respondent's records are inadequate to identify church funds. At times, funds deposited by or for the church appear to have been disbursed for other purposes, but respondent claims any such disbursements were from his own funds. The church filed no complaint, claimed attorney-client privilege, instructed respondent not to disclose information about its records, and strongly objected to the director's inquiry. The church informed the referee through its counsel that it was more than satisfied with respondent's services. The referee concluded that no violations had been proven by clear and convincing evidence, but expressed concern because the *926 bookkeeping in the bond redemption program was extremely unclear.
Ciancanelli Matter. On July 28, 1980, while representing Kevin Ciancanelli in a pending personal injury suit, respondent advanced $7,000 from his office trust account to Ciancanelli. Respondent claimed the advance was a loan, not intended to cover the cost of litigation and also claimed, although the records are unclear, that the money advanced was his own. The referee found violations of DR 9-102(A) and DR 9-103(A), as well as of DR 5-103(B).
Mousel Matter. Respondent commenced a suit against Joseph Mousel while still representing Mousel in another matter, which the referee found to violate DR 5-105(A). Further, when respondent's representation of Mousel ended, he returned the client's papers but required the client to sign a receipt releasing respondent from any liability past, present or future. The referee found that the release was signed "under duress" and was in violation of DR 6-102(A).
Respondent's Books and Records. The referee found, and respondent does not dispute, that respondent's books and records of trust account funds were insufficient to identify clients' funds and property during the years 1978 through 1982. During these years, respondent, in paying his annual registration fee, had certified to this court that he had maintained proper books and records as required by DR 9-103. The referee found an "almost total lack of separation of funds * * * between client funds, personal funds, funds of corporations controlled by Respondent, and fees due," and that respondent regularly used the account for his personal and business interests. The trust account was overdrawn by about $3,000 on February 3, 1978, $4,000 on August 3, 1979, and $2,800 on May 5, 1980, and the referee found these overdrafts could not be explained by delays in banking procedures, as respondent claimed.
The question before us is the appropriate discipline to be given. The referee recommends 5 years' suspension, the director urges disbarment, and respondent asks for probation so he may continue to practice "subject to suitable conditions, until his not too distant retirement." We conclude that the referee's recommendation of suspension should be adopted.
Respondent cites several factors which he claims should weigh in favor of a lesser disciplinary measure than suspension. He says he did not "misappropriate" client funds but, to the contrary, invested them for the benefit of his clients. He points out that the clients earned a good return on their investments; that the funds were returned on request; that, except for Walter Dale Hall, no one has complained about his handling of their monies; and that two of the clients, Mrs. Benke and the Plymouth Baptist Church, have expressed confidence in respondent and satisfaction with his services, and, indeed, objected to the director's investigation. Respondent says he made the challenged investments in good faith and charged no fee for his services. He states that he has made restitution (with the exception of the $5,000 loan to Hall which may still be due the Benke trust, but which respondent claims is not owing, notwithstanding the referee's contrary finding), and that he no longer holds client funds and now maintains proper records.
It does not appear that the challenged loans and investments made by respondent were unauthorized in the sense that they were precluded by the trust agreements. The problem is that the transactions were made without the clients' knowledge in ventures in which respondent had a substantial personal interest. This is a clear violation of DR 5-104(A) ("A lawyer shall not enter into a business transaction with a client if they have differing interests therein * * * unless the client has consented after full disclosure."). See also DR 5-101(A). The conflict in interest is obvious. See DR 5-105. The fact that respondent's clients did not lose their money is a fortuity which does not excuse the disciplinary code violations.
On the other hand, we do not believe the misconduct here warrants disbarment. *927 The facts are not as egregious as in, say, In re Quello, 338 N.W.2d 31 (Minn.1983); In re Moberly, 319 N.W.2d 720 (Minn. 1982); and In re Okerman, 310 N.W.2d 568 (Minn.1981). The referee noted, as mitigating factors, the limited complaints by clients and the lack of any direct loss to the clients. If respondent put himself in an improper position to benefit himself, he also, it appears, desired to benefit his clients. There is also evidence of respondent's good character and a record of substantial charitable and pro bono work. The referee found that respondent is highly regarded by former bar association officers and individuals from the church organization who testified. Respondent has remedied his recordkeeping deficiencies and now does not handle other people's money.
The fact remains, however, that respondent acted seemingly obliviously to his professional responsibilities in handling other people's money. He used money that he was holding for others in his own enterprises. There was extensive commingling of client and personal funds. The recordkeeping was totally inadequate and, if respondent had not been available for the investigation of these matters, it would have been extremely difficult to sort out where matters stood. From 1977 through 1983, respondent had certified in his annual registration statement that his books and records were in compliance with DR 9-103. In 1980, this court, in In re Shaw, 298 N.W.2d 133, 135 (Minn.1980), stated that this kind of misconduct "mandates a severe sanction." Unlike Shaw, where there was a single incident of temporary misuse of a client's funds, for which we gave probation, here the referee found numerous instances of disciplinary rule violations occurring over a number of years. Clearly, respondent's misconduct warrants more than probation or a short suspension.
Respondent is now 63 years old. The referee recommended a 5-year suspension, observing this is more severe than it would be for a younger person, but then added that if respondent were younger, a longer suspension might have been recommended. Yet, in In re Daffer, 344 N.W.2d 382 (Minn. 1984), where a 32-year-old attorney, "[b]linded by greed" and for no reason other than personal gain, engaged in felonious mail fraud, misappropriating over $150,000 accidentally deposited in his investment account, we imposed a suspension of 5 years. In this case, on the other hand, the respondent's misconduct is not as reprehensibly motivated as in Daffer, and, as the referee noted, any protracted suspension would, in a practical sense, be tantamount to disbarment. Also, while the referee found over 40 disciplinary code violations, it needs to be remembered that many of these code violations were for the same behavior. Weighing the seriousness of the misconduct against the mitigating factors, we believe that a suspension of 3 years for respondent should be imposed. We conclude, therefore, that:
(1) Respondent is hereby publicly reprimanded;
(2) Respondent is suspended from the practice of law for a period of 3 years; and
(3) Reinstatement at the end of the suspension period is conditioned on proof that all clients have received all funds due them from respondent.
It is so ordered.
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Extracorporeal treatment of thrombotic microangiopathy: a ten year experience.
We reviewed 24 episodes of thrombotic microangiopathy (TMA) representing 22 patients from July 1989 to July 1998. Nine cases presented with a community acquired (CA group) thrombotic thrombocytopenic purpura or hemolytic uremic syndrome (TTP/HUS), 3 cases were related to pregnancy (P group), 10 cases were compatible with TMA after bone marrow transplantation or chemotherapy (BMT/C group), and 2 cases had a background of scleroderma (SC group). Twenty episodes were treated exclusively with therapeutic plasma exchange (TPE) using fresh frozen plasma (FFP) replacement. In the BMT/C group, 4 patients underwent immunoadsorption with the Prosorba protein A column in addition to TPE. The CA, P, and SC groups had favorable outcomes with 78% (7 of 9), 100% (3 of 3), and 100% (2 of 2) survival, respectively. Despite intensive therapy, there was only 1 survivor in the BMT/C group (1 of 10). Successful outcome required up to 57 TPE treatments. We could not document any benefit to immunoadsorption with the Prosorba protein A column. |
Roly China Fusion is proud to offer the Greater Palm Springs area a VIP Culinary Experience at The Chef’s Table. This exclusive, private dining experience features their most exquisite offerings, with a menu changing day to day. Up to twelve guests can pull up a seat for an intimate, interactive and engaging culinary presentation. |
Laura Place, Bath
Laura Place Bathwick, Bath, Somerset, England, consists of four blocks of houses around an irregular quadrangle at the end of Pulteney Bridge. It was built by Thomas Baldwin and John Eveleigh between 1788 and 1794.
Numbers 4, 5 and 6 are combined with Numbers 1 to 7 Great Pulteney Street, and others with Henrietta Street.
History
The fountain at the center of the quadrangle was not part of the original plan; it was added in the late 19th century. After completion of the main street in 1877 local residents petitioned and successfully raised significant funds to build a grand column (rather like Nelson's Column in London). However, as construction of the column started, the residents realised that the addition would tower over the area (it would be 50% taller than the houses), and so they then petitioned for it to be cancelled. After some negotiations, the column was pulled down and the much smaller fountain added instead. It consists of a circular stone basin with four radial projections surmounted by an urn with gadrooned bowl.
See also
List of Grade I listed buildings in Bath and North East Somerset
References
Category:Grade I listed buildings in Bath, Somerset
Category:Grade II listed buildings in Bath, Somerset
Category:Streets in Bath, Somerset |
URL1=https://people.eecs.berkeley.edu/~taesung_park/projects/CycleGAN/models/places_vgg.caffemodel
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URL2=https://people.eecs.berkeley.edu/~taesung_park/projects/CycleGAN/models/places_vgg.prototxt
MODEL_FILE2=./models/places_vgg.prototxt
wget -N $URL1 -O $MODEL_FILE1
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After Dark Acquires ‘Zombies of Mass Destruction’
The official rating was given to ZMD: Zombies of Mass Destruction, which revealed that the film was acquired by After Dark Films and will probably be one of the “8 Films to Die For” is this coming January’s After Dark Horrorfest IV. It was rated R for “strong bloody zombie violence and gore, language, sexual references and brief drug use.” Life in a conservative small town is complicated enough for a young Iranian-American woman and a not-completely-out gay couple, but now they also have to deal with zombie hordes in this splatter-filled comedy. Visit the film’s official website for more. |
Q:
python regex match single quote
I try to match single quote in below:
s= "name:'abc','hello'"
but seems the behaviour of match/findall is different:
re.match("\B'\w+'\B", s) # ===> return None
re.findall("\B'\w+'\B", s) #===> RETURN ['abc', 'hello']
actually this is caused by single quotes in the string, anyone knows what's going on?
I'm using py2.7.8 in win7.
A:
See https://docs.python.org/2/library/re.html#search-vs-match -- "Python offers two different primitive operations based on regular expressions: re.match() checks for a match only at the beginning of the string, while re.search() checks for a match anywhere in the string (this is what Perl does by default)."
You're using re.match(); if you switch to re.search(), you'll get the behavior you were expecting.
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The War on Child-Marketed Nicotine Products Continues
E-cigarette companies have 60 days to reverse child-marketed nicotine campaigns
In a recent press release, the FDA ordered the top five e-cigarette manufacturers to reverse the recent trends of child-marketed nicotine campaigns. The agency has given each company 60 days to submit plans describing how they will address youth access and use of their products. JUUL, Vuse, MarkTen XL, blu e-cigs and Logic currently amount to over 97 percent of the US e-cigarettes market.
“…we see clear signs that youth use of electronic cigarettes has reached an epidemic proportion, and we must adjust certain aspects of our comprehensive strategy to stem this clear and present danger,” said FDA Commissioner Scott Gottlieb. “We cannot allow a whole new generation to become addicted to nicotine. In the coming weeks, we’ll take additional action under our Youth Tobacco Prevention Plan to immediately address the youth access to, and the appeal of, these products.” If they fail to do so, the brands may be required to remove their child-targeted products from the market entirely.
In June, the FDA issued 1,300 warning letters and civil money penalty complaints to retailers who were found to be selling e-cigarette products to minors during an undercover investigation this summer. According to the FDA, this is the largest enforcement effort in the agency’s history. Click here to read a sample letter.
In May, the agency issued 17 warning letters to e-liquid manufacturers, sellers and retailers that were marketing their products to children. The letters were issued to companies advertising nicotine-containing liquids “e-liquids” as kid-friendly food products (See Figure 2). Subsequently, these products are no longer being sold by those companies that received warnings. However, many of the retailers that received their share of the recent 1,300 warning letters are still selling the violating nicotine products.
According to a 2017 survey, many students did not associate e-cigarettes with nicotine use. 66 percent of surveyors stated that they vape “just flavoring” and not nicotine. 13.7 percent stated that they didn’t know what was in their e-cigarette and 5.8 percent said marijuana. This is likely a result of high teen exposure to e-cigarette marketing and advertising (See Figure 3). |
Freshen Up Your Routine Today With These Quick Tips
I love when the change of the season is upon us because it means a shift of consciousness for all. We change the way we tackle our day, the way we handle our weekly routines, and we even change our beauty habits to deal with the climate shifts. As a beauty buff, there’s nothing I look forward to more than a makeup refresh. My skin needs it. My mind needs it. My soul needs it!
So, how do I freshen up my life at the turn of each season? Easy! I look at what changes have occurred and then tend to those needs.
Skincare: SPF always remains in all of my beauty products year round, but during the colder months I opt for moisturizers that offer a thicker barrier to help me combat the harsher weather I’m about to face.
I also look for body wash that offers the same benefits — looking to moisturize more during my shower because my dry skin will need it throughout this time of the year.
Seasonal Scents: I’m a sucker for a good Fall or Winter scent. As soon as the leaves begin to fall, I run to the store and buy all the pumpkin spice products I can find.
Seasonal Cleaning: Back to School is the start of a mom’s new year and personally that’s when I start to clean out all excess clothing, toys, blankets, sheets and kitchen supplies that I’ve been holding onto all year long. This is when my annual purge begins. I continue to shed excess weight until right before Christmas when I then refill my house up with more household items than one could ever need. But hey! It feels good for a few months to have less and I actually LIKE getting rid of things we don’t need. I highly suggest you add this process to your routine.
Hair Masks: To prepare for the winter, I also do a hair moisturizing sealing treatment at the salon. After I get a fresh new cut, I spend a few extra dollars to help strengthen my cuticles and my locks always thank me for it later. You can continue maintenance on your own at home with drugstore buys that are super affordable and effective. However, for your first seal lock, I do suggest hitting up the salon.
CLEAR CARE®PLUSwants to help you continue to freshen up this season by giving your contact lenses that fresh lensfeeling. CLEAR CARE® PLUShas active bubbles to clean your lenses in a way no multi-purpose solution can. Contact lenses are absolutely one product that you want to ensure are as clean as can be! Switch from your basic multi-purpose solution and take your lens care to the next level today for cleaner-feeling lenses, better lens comfort and more hours of comfortable lens wear.
Curious how to use CLEAR CARE® PLUS? No problem! Check out the easy cheat sheet above. This can serve as a great reminder for first-time users and old pros alike!
BONUS: If you are looking for a $5 off coupon, click here. The brand is offering one online and it is too good to pass up.
So, how are you going to freshen up your routine this year? It’s always a great way to jump right into a season and get excited for what’s to come.
About me
Vera Sweeney, mom, blogger, social media influencer and New York resident, is the founder of LadyAndTheBlog.com. She is considered one of the top female digital influencers in today’s social media space. Her lifestyle and parenting brand helps busy women stay on top of the latest trends in fashion, food, family and travel. |
As hydrocarbon wells mature, they exhibit a decrease in bottom-hole pressures and the production velocities, which are necessary to carry fluids—e.g., produced water, oil and condensate—to the surface. Over time, these fluids can accumulate in the downhole production tubing, resulting in a condition known as liquid loading. Toward the end of the production life of the hydrocarbon well, as formation fluid accumulates at the bottom of the wellbore, the liquid loading may reach a level that interferes with the well's performance. In particular, the well loses energy as the reservoir's natural pressure is countered by the hydrostatic head created by the accumulated fluid. The lost energy in the well necessitates employing measures to lift the formation fluid to the surface to prevent the liquid-loading condition from killing the well. Several techniques exist for artificially lifting formation fluids, including plunger lift systems. Plunger lift systems attempt to remove fluids from the wellbore so that the well can be produced at the lowest bottom-hole pressure and maximum rate by harnessing the well's own energy to remove the accumulated fluids and sustain gas production. Conventional plunger lift systems rely on a piston dropped into a flowing or non-flowing wellbore. A bumper spring at the bottom of the well cushions the impact of the piston. Gas flowing into the well below the piston pushes the piston upward, thereby pushing any formation fluid toward the surface. These pistons—e.g., pad, solid, bypass, and brush plungers, etc.—may have fluid fallback due to insufficient sealing with the tubing/casing wall.
There are problems with using conventional tubular-shaped plungers in deviated and vertical wells. Such plungers may not have a sufficient seal, thereby causing undesirable fluid fallback to occur. Typical sealing devices are constructed from steel and/or fibers. These seals fail over time. The lack of seal may allow the well to liquid load over time because of fluid fallback. Liquid loading occurs when the hydrostatic pressure of the fluid is greater than the gas pressure below, restricting gas from surfacing through the surface equipment. The conventional tubing coupling collar used in the industry has a gap between each tubing joint. This gap in the inside diameter of the tubing allows fluid to be trapped at each connection and is an obstruction to making contact between the plunger and seal. Contact with artificial lift tools and this tubing/collar gap will cause premature wear, breakage, and fluid fallback.
Thus, there is a need for a plunger lift system that reduces fluid fallback and more efficiently lifts formation fluid to the surface. |
Counting down the days
It’s 5 days till I have to report in to the Funhouse to start the conditioning treatment for my transplant. To say that I have mixed feelings is an understatement. Now I look forward to sleepless nights, a screaming baby, nappy changing, late night feeds and fumbles, more nappy changing, more formula making and baby poo.
At the Funhouse, it will be beeps, whooshes, yet more meds, more poison, more radiation, bloods and crappy food. Honestly I pick baby poo and sleepless nights any day of the week.
On the one hand I understand how important it is to go through with the transplant and how essential it is to get well. But on the other hand I abhor the fact that I have to be away from the wife and Sophie for at least 4 weeks. Not to mention the stress and worry that they will be under when I am undergoing the treatment.
Also not looking forward to the boredom and the fact that I have to be confined to the room for most of the treatment. I’ll be having treatments most of the day every day leading up to day zero. Depending on my bloods, they may let me go to the scrubs or to the restaurant or shops during that time. After the infusion, I will probably need to be in the room for most of the time. I can’t even head out to pantry to get a cup of coffee!
I am ‘stocking up’ on all the games, movies, tv shows and entertainment of any sort that I can get my cyber hands on to prepare for the 4 weeks of insane boredom in the hospital. The wife reckons that I should watch at least one comedy show a day (laughter being the best medicine and all that) so I’ve obtained the entire Black Adder series. That should last me a while. 🙂
Whatever it is, I just have one goal in mind. Getting out and getting better. Even then it’s going to be back for regular follow ups, but at least it will be the end of chemotherapy. And the follow ups will end. Eventually. So after that it’s all about spending quality time with my little family. And that’s something to look forward to. 🙂 |
Burying the Children
The deliberate murder of the Jewish baby, Shalhevet Pass, by a Palestinian sniper was condemned around the world, leaving people everywhere to wonder how a human being could line up a baby’s head in the crosshairs of his sniper scope and pull the trigger.
But the atrocity apparently had a different effect on some reporters who have toiled for six months to present a “balanced and even-handed” portrayal of the fighting — or in some cases a sympathetic picture of the Palestinian side. These reporters have mitigated Palestinian terrorist bombers by calling them “militants,” while whenever possible labeling Israeli victims as “settlers” — in an attempt to “downgrade” them from the ranks of innocent civilians.
So how did the “even-handers” handle Shalhevet’s funeral?
On April 2, The New York Times ran Deborah Sontag’s report headlined “Israeli Baby’s Funeral Becomes Focus of Settler Militancy.” Sontag reminds readers several times of Palestinian casualties in describing Shalhevet’s funeral: “One [Jewish mourner] held a framed photograph of Shalhevet in her Purim costume, in the style of the Palestinian mothers who grieve for their martyred sons.”
That sentence provided Sontag with the perfect and immediate segue into her reminder of youthful Palestinian casualties killed by Israelis: “An 11-year-old Palestinian boy, Muhammad Tamini, was buried today in a small quiet funeral in his village near Ramallah. The boy died of wounds sustained in clashes with Israeli troops two weeks ago.”
In her search for evenhandedness, Sontag then finds a backhanded way to portray Shalhevet as a despised settler: “Many Israelis have long considered the Hebron settlers to be extremists, living in a world apart. But they rallied behind the community after Shalhevet was killed; newspaper headlines referred to the killing of an Israeli baby and not a “settler baby.”
Sontag makes the outrageous implication that Jews might normally disregard the ruthless murder of another Jew, simply because they don’t share the same political views. Is the average Israeli so petty and cold-hearted? I don’t believe so. But perhaps Sontag is.
Goldenberg then attempts to “even out” the atrocities: “Few Palestinians shed tears for Shalhevet. About 130 of the 455 people who have been killed in the uprising were Palestinians under the age of 18, the latest an 11-year-old Ramallah boy who was also buried yesterday, after being shot in the head by an Israeli soldier.”
In Goldenberg’s eyes, two children have been shot in the head, and there is no distinction to made. But the comparison, of course, is false. No Israeli soldier has ever aimed to kill innocent children sitting in baby carriages or playing in a sandbox. Tragically, Palestinian children are shot when they participate in violent demonstrations or by errant bullets that may have also come from Palestinian gunmen shooting at Israeli soldiers.
Of course, the Muhammad al-Durrah incident left a lot of questions unanswered, the most important being what he and his father were doing in the heart of crossfire shooting, whether it was actually an Israeli or Palestinian bullet that struck him, and how the media came to be perfectly placed to photograph it. Is this comparable to Shalhevet being murdered in cold blood on the playground?
CNN had its own version of even-handedness: “Two children on either side of the Israeli-Palestinian conflict are being buried on Sunday. Jewish settlers are burying a 10-month-old girl killed by sniper fire while Palestinians are burying an 11-year-old boy shot during clashes with Israeli forces.”
Meanwhile,Los Angeles Times reporter Tracy Wilkinson downplayed the Arab identity of Shalhevet’s killer, leaving it as mere Israeli “hear-say.” She writes: “Jewish settlers buried 10-month-old Shalhevet Pas on Sunday, six days after the army says she was shot dead by a Palestinian sniper… Shalhevet was shot to death and her father, Yitzhak, was wounded by what Israeli authorities say was a single bullet from a Palestinian gunman.”
If you feel that the reports are biased, write to these publications at:
Thank you for your ongoing involvement in the battle against media bias.
HonestReporting.com
======================================
NOTE TO HONESTREPORTING MEMBERS:
Last week, we wrote about the media’s aversion to call Palestinians “terrorists” — even when referring to suicide bombers. Since then, both The New York Times and CNN have referred to Palestinian acts of “terror.” |
Q:
Double Quoted Strings in C++
How to converted string with space in double quoted string.
For Example:
I get string
c:\program files\abc.bat
I want to convert this string to "c:\program files\abc.bat" but only if there is space in the string.
A:
Assuming the STL string s contains the string you want to check for a space:
if (s.find(' ') != std::string::npos)
{
s = '"' + s + '"';
}
|
Q:
jaxb marshal included class without root tag
I need marshal class with included class fields, but without included class root tag. For example I have class Person and Address:
@XmlRootElement(name="address")
class Address {
...
@XmlElement
String street;
}
@XmlRootElement(name="person")
class Person {
...
@XmlElement
Address address;
}
If I marshal it i get:
<person>
...
<address>
<street>...<street>
<address>
</person>
But I need:
<person>
...
<street>...<street>
</person>
A:
A possible solution could be ..
@XmlRootElement(name="address")
class Address {
...
@XmlElement
String street;
}
@XmlRootElement(name="person")
class Person {
...
@XmlTransient
Address address;
@XmlElement
public String getStreet() {
return (address!= null) ? address.getStreet() : null;
}
}
|
Looking for advice on building audio and/or video chat into my web site
If this is your first visit, be sure to
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Looking for advice on building audio and/or video chat into my web site
Hello -
Toying with the idea of adding the ability to have audio and/or video chat embedded right into a web site I am working on. I would like it to be peer to peer, and I have looked at SkypeKit and some of the Google Chat/Talk APIs, but was wondering if somebody knows of anything existing I could leverage. |
The future is now.
The New York Yankees are reportedly calling up top prospect Gleyber Torres ahead of Sunday's series finale against the Toronto Blue Jays, a source told Jack Curry of YES Network.
Torres was removed from Saturday's game for Triple-A Scranton, and will be with the Yankees for Sunday's game. Apparently, the 21-year-old infielder initially thought he was leaving the game because he didn't hustle on a ground ball.
When Gleyber Torres was pulled from the game, he did think it was because he didn’t run out the grounder. Said he’s super happy to finally achieve his dream. #Yankees — DJ Eberle (@ByDJEberle) April 21, 2018
He will be the second of MLB Pipeline's Top 10 prospects to get the call to the majors in 2018, with Los Angeles Angels' Shohei Ohtani breaking camp with the club.
Torres has been lighting it up in Triple-A, boasting a slash line of .370/.415/.543 with a home run, three doubles, and a triple through 13 games. He has split time between second base, shortstop, and third base this season, though the bulk of his playing time has come at the hot corner.
With third baseman Brandon Drury still on the shelf with migraines and second basemen Neil Walker and Tyler Wade struggling at the plate, Torres could very well be in line for an extended stay.
Torres' ascension through the minors has been relatively meteoric since the Yankees acquired him from the Chicago Cubs in a trade that sent reliever Aroldis Chapman the other way in 2016. He had never played above Single-A before 2017 and now he's about to make his MLB debut. |
Jakub Jasiński
Jakub Jasiński of Rawicz Clan (24 July 1761, in Węglów near Pyzdry in Greater Poland – 4 November 1794, in Warsaw, Poland) was a Polish general, and poet of Enlightenment. He participated in the War in Defence of the Constitution in 1792, was an enemy of the Targowica Confederation and organized an action against its supporters in Wilno. He participated also in the Kościuszko Uprising, during the course of which he was killed in the Battle of Praga in 1794.
A graduate of the Warsaw-based Szkoła Rycerska, with time he became the tutor of engineering at his alma mater. He fought with distinction in the War in Defense of the Constitution of 1792. After the king joined the Targowica Confederation he remained loyal to the new authorities. In 1789 he became the commanding officer of the Engineering Corps for Lithuania.
War in Defence of the Constitution
He participated in the Battle of Brześć in July 1792, for which he was awarded the military award Virtuti Militari.
Despite his antipathy towards the Confederation of Targowica, opposed the Constitution of 3 May which Jasiński had defended, during this time he pledged his loyalty to it, not giving up conspiratorial activities against it.
The war of liberation
During the Kościuszko Uprising of 1794 Jasiński was among the most prominent members of the radical wing of the Polish Jacobins and at the same time a successful military commander of partisan forces in the area of the Grand Duchy of Lithuania. In April of that year he liberated the city of Wilno by leading a successful uprising there. Supported by Tadeusz Kościuszko and appointed the commander in chief of all the partisan forces in the former Grand Duchy, he managed to defeat numerous Russian garrisons in the area. However, accusations of radical republicanism brought him into conflict with the state authorities, and by the beginning of June he was forced to resign as commander-in-chief of Lithuanian forces and pass his office to General Michał Wielhorski. Jakub Jasiński continued to harass enemy forces in Lithuania and then withdrew with a small partisan troop towards Warsaw. There he perished in November during the defense of Warsaw against the forces of Alexander Suvorov.
Among his literary works are numerous poems of satirical and fabled character, under huge influence of Voltaire, for example Jasiński's better-known "Sprzeczki" (Quarrels). He was also an author of many patriotic and revolutionary poems and songs against injustices, inspired by the French Revolution, and arousing hope of a similar one in his homeland.
Commemoration
In Poland, there are or were a number of streets named after Jakub Jasiński, including in Warsaw, Chorzów, Częstochowa, Gliwice, Inowrocław, Kraków, Lublin, Łódź, Przemyśl, Radom, Świdnica, and Zielona Góra.
Outside Poland, he is also commemorated in the names of Streets in Belarus, where there is a street named after him in Maladzyechna as well in Lithuania, where he has a street both in the Old Town of Vilnius and in Kaunas. Belarus also released a stamp with his image in 1994.
Notes and references
Category:18th-century Polish poets
Category:Generals of the Polish–Lithuanian Commonwealth
Category:Generals of the Kościuszko Uprising
Category:Kościuszko insurgents
Category:People of the Polish–Russian War of 1792
Category:1761 births
Category:1794 deaths
Category:People from Września County
Category:Polish generals
Category:Polish nobility
Category:Clan of Rawicz
Category:Polish male poets |
/*
* Copyright 2014-2017 Lukas Krejci
* and other contributors as indicated by the @author tags.
*
* Licensed under the Apache License, Version 2.0 (the "License");
* you may not use this file except in compliance with the License.
* You may obtain a copy of the License at
*
* http://www.apache.org/licenses/LICENSE-2.0
*
* Unless required by applicable law or agreed to in writing, software
* distributed under the License is distributed on an "AS IS" BASIS,
* WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
* See the License for the specific language governing permissions and
* limitations under the License.
*/
package org.revapi.java.checks.fields;
import java.util.Collections;
import java.util.EnumSet;
import java.util.List;
import java.util.Objects;
import org.revapi.Difference;
import org.revapi.java.spi.CheckBase;
import org.revapi.java.spi.Code;
import org.revapi.java.spi.JavaFieldElement;
/**
* @author Lukas Krejci
* @since 0.1
*/
public final class NowConstant extends CheckBase {
@Override
public EnumSet<Type> getInterest() {
return EnumSet.of(Type.FIELD);
}
@Override
protected void doVisitField(JavaFieldElement oldField, JavaFieldElement newField) {
if (!isBothAccessible(oldField, newField)) {
return;
}
if (oldField.getDeclaringElement().getConstantValue() == null
&& newField.getDeclaringElement().getConstantValue() != null) {
pushActive(oldField, newField);
}
}
@Override
protected List<Difference> doEnd() {
ActiveElements<JavaFieldElement> fields = popIfActive();
if (fields == null) {
return null;
}
return Collections.singletonList(
createDifference(Code.FIELD_NOW_CONSTANT,
Code.attachmentsFor(fields.oldElement, fields.newElement,
"value", Objects.toString(fields.newElement.getDeclaringElement().getConstantValue()))));
}
}
|
Q:
Install memcached on Ubuntu 12.04
sudo pecl install memcached
It prompts:
libmemcached directory [no] :
Tried the default value and a lot of different directories and downloaded source. Sure do enjoy these vague error messages.
Where do I find the files it is looking for and what exactly is it looking for?
Searched for hours already and nothing seems to help.
I tried compiling from source, but I ran into a lot of warnings and error messages and to top it off the php-memcached project doesn't seem to contain a configure script.
./configure
"File or directory not found" this is the error. It wants libmemcached directory but I don't know what should be inside of that directory.
I just want it to load in php any way possible. This is on a development VM so it doesn't need to be production ready. Just needs to work.
[Edit]
I have memcache installed but I need memcached instead.
I'm using:
Bitnami lampstack 5.4.29-0 Ubuntu 12.04
[UPDATE]
I found this:
So I recommend to use/install the official memcached extension from PECL and update your application.
https://github.com/kajidai/php-libmemcached
Else you have to install the libmemcached extension from scratch with the following steps:
download from github
unpack the file
go into the new folder
phpize
./configure
make install
enable it within you php.ini
restart you webserver
got to this:
./configure
checking for the location of libmemcached extension... configure: error: Can not find libmemcached headers
More vague error messages.
[UPDATE]
I solved the issue by upgrading to 14.04. Seems that was the fastest route to solve my issue.
A:
Install the "libmemcached-devel" package with yum (RHEL/CentOS/CloudLinux) or the "libmemcached-dev" package with apt-get (Debian/Ubuntu).
Once installed, the default answer of "[no]" is fine because the headers will be in the system-wide default location of "/usr/include/libmemcached-1.0", which the configure script will find on its own.
NOTE: You may be tempted to install "memcached-devel", but it is not the same thing as "libmemcached-devel". Between that, and the subtle naming differences between the "memcache" and "memcached" PECL packages, I suspect there are several developers that need to be smacked.
|
Reddit seems to have been blocked in China, in yet another widening of the country’s “Great Firewall”.
The social news site joins most other major American web services — including Google, YouTube, Facebook, Twitter and Instagram — in being blocked from inside the country. Sites including Reddit may be accessible through virtual private networks (VPNs), but China has been cracking down on those too.
The website Blocked In China shows the site as unavailable from computers in all of the regions that are tested: Beijing, Shenzhen, Inner Mongolia, Heilongjiang Province and Yunnan Province.
On Reddit itself, some users were still able to access the site. The blocks are done in such a way that they can show initially only in some areas — but sometimes sites are blocked and then made available again without notice.
China has been gradually blocking more and more sites as part of what it calls the “Golden Shield Project”. The country says that the blocks are intended to keep dangerous content out of the country — and the block tend to cover sites that people use to talk about topics that the country doesn’t want discussed, or places that are used to share content that authorities deem obscene. |
The present invention relates to a liquid dispensing device comprising a liquid dispensing appliance and a reservoir to be fitted thereinto.
Spray devices are known for the purposes of domestic cleaning, for example for cleaning hard surfaces such as windows, baths and ovens, as well as for spot cleaning of floor coverings such as carpets. Most spray devices which are commercially available are manually or electrically operated, that is to say that the devices comprise a pump which is activated or operated by the consumer. Most commonly this activation generates liquid pressure in a chamber by means of a positive deplacement pump by means of a positive deplacement pump which in turn drives the liquid from the chamber usually through a dispensing nozzle. Many dispensing patterns are possible, but a conical spray is the most common. Usually, such spray devices comprise a reservoir filled with an active composition, and a means to dispense the composition from within said reservoir. The spray devices typically further comprise a basic fitment system to secure the reservoir onto the dispensing means, so as to establish a fluid communication between the two.
Some of these fitment systems comprise a needle that connects the dispensing means and the reservoir in a leak tight-manner, through a pierceable member.
The following references are directed to devices comprising a reservoir and a dispensing means which are fitted to each other by means by a needle/pierceable member:
D1 (U.S. Pat. No. 5,389,085) is a US patent to International Medical Consultants, Inc. It discloses an automatic needle protector, especially for use with a syringe. The needle protector comprises a cylinder slidably mounted via a spring onto the syringe. In normal position, the spring pushes the cylinder, which surrounds the needle. When a vertical pressure is applied onto the cylinder, and the cylinder slides down, giving access to the needle.
D2 (U.S. Pat. No. 5,486,163) is a US patent to Haynes Miller, Inc. It discloses a shield for protecting the needle of a syringe, with an annular connector for connecting the two, and comprising at least one protective arm hingedly mounted upon the connector and pivotable between a first protecting position, and a second open position.
After removing the reservoir from the appliance, the needle is accessible by anyone who would put his hand into the appliance""s recess. Such needles are typically very sharp, and likely to cause injury upon contact, more particularly if some dispensed product remains on it. This is the case for any type of user, but especially in the case of children. Indeed, it has been shown that children are very curious and while playing, they tend to put their hands into the recess of the dispensing appliance.
Therefore, such appliances should comprise a protecting means that is locked in a position to prevent access to the needles, unless a reservoir suitable for use with said appliance is inserted thereinto. Thus there is a need for a reservoir suitable for use with a dispensing appliance, said dispensing appliance comprising a piercing means to pierce a pierceable means of said reservoir so as to establish a fluid communication between said reservoir and said appliance, said appliance further comprising a protecting means releasably locked in a position so as to prevent access to said piercing means, said reservoir comprising means to unlock said protecting means when said reservoir is inserted into said appliance.
The present invention is directed to a device comprising an appliance, and a reservoir suitable for being removably connected to said appliance, said appliance comprising at least one piercing means and said reservoir comprising one pierceable means, said appliance comprising a releasable protecting means for preventing access to said piercing means when said reservoir is not connected to said appliance. The present invention is further directed to said appliance, and also to said reservoir.
In a preferred embodiment of the invention, the appliance comprises an actuation trigger to release said protecting means and give access to said piercing means, and said reservoir comprises a releasing means to cooperate with said actuation trigger in releasing said protecting means. Also preferably, said appliance and said reservoir are provided with cooperating securing means, so as to ensure that said reservoir is secured into said appliance, once connected thereinto. |
Sir,
Candidemia is the most common invasive mycotic infection across India. It is most commonly seen in immunosuppressed or immunocompromised patients. The important risk factors include the use of immunosuppressive drugs, and/or broad-spectrum antibiotic therapy, abdominal surgery, parenteral nutrition, haemodialysis, haematological disorders, HIV infections, solid tumours, mucosal or cutaneous barrier disruption, extremes of age, prolonged ICU stay and central venous catheter use[@ref1]--[@ref5]. *Candida albicans* is of the foremost importance as opportunistic pathogen in immunocompromised hosts, which may cause life threatening infections. In the recent years, an increase in opportunistic infections caused by other *Candida species, viz. C. tropicalis, C. parapsilosis, C. krusei* and *C. glabrata*, has been increasingly reported[@ref2]--[@ref5]. The epidemiology of systemic *Candida* infections varies in different regions, and frequently from one hospital to another within the same region[@ref2]. Further, *C. glabrata* and *C. krusei* have been noted to have decreased susceptibility or resistance to fluconazole[@ref6][@ref7]. In India, mortality in candidemia varies from 28 to 71.4 per cent[@ref1]. Rapid and accurate species identification is necessary to optimize the choice of antifungal therapy. The aim of this study was to assess the candidemia profile in clinically diagnosed consecutive cases of fungemia at Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, by germ tube production, morphology on corn meal agar (CMA) and colour production on Hichrom candida agar[@ref8][@ref9]. Antifungal susceptibility of the isolated *Candida* species was tested by disc diffusion method against amphotericin B (10 U) and fluconazole (25 μg) on Mueller-Hinton Agar supplemented with 2 per cent glucose and methylene blue (5 μg/ml). Zone diameter endpoints were read at 80 per cent growth inhibition and were interpreted as per approved Clinical and Laboratory Standards Institute (CLSI - M44-A) guidelines[@ref10].
*Candida* species were isolated from 31 patients (50%) from the 62 blood samples received in the mycology section, Department of Microbiology, JIPMER, Puducherry, during October 2009 to March 2010. Of the 31 isolates, 19 (61.3%) were isolated from females and 12 (38.7%) from males; 80.6 per cent (n=25) were isolated from patients admitted in intensive care units (ICU); 61.3 per cent (n=19) isolates were obtained from patients with age ≤10 yr, 12.9 per cent (n=4) from ≥51 yr, 6.5 per cent (n=2) each from 21-30 and 41-50 yr, and 9.7 per cent (n=3) from 31-40 yr.
Species identified by morphology on corn meal agar (CMA) and Hichrom candida agar were the same. Most common isolate was *C. parapsilosis* (64.5%) followed by *C. tropicalis* (19.4%), *C. albicans* (9.7%) and *C. glabrata* (6.5%). Only two species of *C. albicans* were isolated and both were germ tube test positive. Twenty nine isolates (93.5%) were sensitive to amphotericin B and 24 (77.4%) to fluconazole by disc diffusion method.
*Candida* was isolated more from female subjects as compared with male subjects in our study whereas it was isolated predominantly from male subjects in similar study from Brazil[@ref2] and Kerala[@ref11]. Extremes of age are important risk factor for candidemia[@ref4]. *Candida* was isolated most frequently from children ≤10 yr and those ≥51 yr of age group in our study. Candidemia is growing problem in intensive care unit (ICU) patients, as shown in our study also. The results coroborated with the other studies from India[@ref11][@ref12]. A surveillance programme (SENTRY) of bloodstream infections (BSI) in the United States, Canada, Latin America, and Europe from 1997 through 1999 detected 50 per cent isolates from ICU admitted patients[@ref13].
Most of the laboratories use germ tube test for the rapid and cost-effective presumptive identification of *C. albicans*[@ref14][@ref15]. It has been reported that up to 5 per cent of *C. albicans* isolates are germ tube negative[@ref15]. Reporting time can be further reduced by using the germ tube test directly from the positive blood culture bottle with 87.1 per cent sensitivity and 100 per cent specificity[@ref16]. Germ tube method, although simple, requires a microscope and a skilled microscopist familiar with mycology methods[@ref14]. Species identification is most commonly done by chromogenic agar or corn meal agar morphology method. We used both the methods and observed 100 per cent concordance between the two methods.
The epidemiology of systemic *Candida* infections varies in different regions[@ref2], but the change in the pattern of yeast profile has been observed globally in recent years. *C. albicans* isolation is decreasing and non-albicans *Candida* especially *C. parapsilosis* isolation is increasing[@ref2]--[@ref5][@ref11]--[@ref13][@ref17]--[@ref22]. The most common pathogen is still *C. albicans* in USA, Europe, Spain and Brazil[@ref2][@ref4][@ref13][@ref18][@ref19] while *C. tropicalis* was isolated predominantly from India[@ref3][@ref11][@ref17]. *C. parapsilosis* was the most common isolate in our study similar to another study from New Delhi[@ref17]. It may be because 61.3 per cent of the isolation was from children (≤10 yr) and *C. parapsilosis* is a predominant pathogen amongst children[@ref18][@ref19][@ref21][@ref22]. It is mandatory to monitor the fungal spectrum in a particular geographical area to obtain relevant epidemiological data and the *Candida* susceptibility profile to anti-fungal drugs to assist in the management and treatment of hospitalized patients with *Candida* infection.
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Q:
multiple angular filter for text but also greater than / less than
tr.row(ng-repeat="i in items | filter:search"
input(type="text" ng-model="search.desc")
input(type="text" ng-model="search.comment")
This works marvelously, I can filter items by desc and comment.
Now, I also need to filter by
amount
date
Both will have an input for greater than and less than (resp. after / before).
For example for amount:
input(type="text" ng-model="search.amount") //this one would be the minimum value input
input(type="text" ng-model="search.amount") //this one would be the maximum value input
How can I combine this with the already working desc and comment filters which I would rather want to keep? I guess I will have to write some custom function - but could I combine this harnessing the existing text filtering?
Note on syntax: using jade template engine on nodejs
A:
I think you have to write some code to check whether the amount satisfies. Since filters can be chained, its harmless I think.
first you name min & max amount
input(type="text" ng-model="search.minAmount") //this one would be the minimum value input
input(type="text" ng-model="search.maxAmount") //this one would be the maximum value input
in your controller, define a function
$scope.matchAmount = function(item){
reuturn item.amount >= $scope.search.minAmount && item.amount <= $scope.search.maxAmount
}
finally,use it in you template
ng-repeat="i in items | filter:search | filter: matchAmount
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"Parvati!" "Parvati, where were you?" "We've been searching for you." "Where did you vanish to?" "You were searching for me needlessly, jaya." "I was, where i should be at shiva's refuge." "Yes, i forgot." "I forgot that since you became aware of the world you've thought of shiva as your husband." "Not the awareness of the world but since i was born." "That's alright." "But your wedding has been fixed to the prince of vindhyachal, isn't it?" "Parvati has been born to marry shiva." "Neither am i aware of anybody else nor do i wish to." "He can be the prince of any kingdom... but neither have you met shiva and nor do you know him." "Where is he?" "How will you meet him?" "I've only loved shiva and i'll be his wife alone." "It's my resolve." "And if he doesn't come to me then i'll go to him." "Mother." "Does it ever happen in life that we get what we dream of?" "There's a lot of difference between dreams and reality." "I just know that you should leave behind dreams and accept reality." "Life will be happy and prosperous." "If there's any illusion in your mind then you shouldn't let it grow." "Remove it at the earliest." "O lord... will we allow mother parvati's faith to be tested in this manner?" "Parvati's love for shiva can't be removed by anybody." "Not even by parvati herself." "Yes... this wait is difficult but it's unavoidable." "Before the union the longer the wait the more stable will the union be." "This love isn't just love but a penance." "And after this penance parvati will attain shiva." "'My eyes are tired... ' '... staring at the path in wait... ' 'my tongue has blisters on them... ' '... chanting the name of rama.' '... chanting the name of rama.'" "'... chanting the name of rama.' '... chanting the name of rama.'" "Salutations, o sage." "Lady... what do i see in your eyes?" "You await someone's arrival." "No, sage." "I don't await anybody." "It isn't true." "Yes... you're surely disappointed." "Because you're unable to find the one you search for." "But lady... it's also possible that the one you search for he too, searches for you in this world." "What's being delayed is your union." "And this will surely happen." "It has to." "Salutations, sage." "Lady... what do i see in your eyes?" "You await someone's arrival." "You're surely disappointed." "Because you're unable to find the one you search for." "What's being delayed is your union." "Your highness!" "Your highness!" "What is it, my lady?" "You appear worried." "Parvati is nowhere to be seen." "You don't need to worry, my lady." "Commander!" " Yes, your majesty." "Split our army into twenty and send them to every mountain." "And search every corner of our kingdom and find the whereabouts of my daughter." "As you say, my lord." "Parvati!" "Parvati!" "Parvati!" "Parvati!" "Parvati!" "Parvati!" "Parvati!" "Open your eyes, parvati." "Look... i'm your father, i've come to take you." "There's nothing to worry anymore." "Nothing can harm you." "Parvati!" "What happened to you, dear?" "You can't leave your parents like this." "Open your eyes, parvati!" "You're alive!" "Yes, himavan, your daughter is alive." "Himavan... how can the one on whom all creation depends, die?" "Whenever i assume my true form then he's known as the supreme lord that is shiva." "That shiva is lost in meditation in this cave." "And your daughter goddess parvati is none but adi shakti, herself." "She's born to reunite with shiva." "For the benefit of the world." "That's why, in search of shiva goddess parvati reached here." "Himavan... remove all obstacles from the path of parvati and help her in attaining shiva." "Forgive me, lord." "Years ago, i promised parvati's hand to the king of vindhya." "How then can i get parvati married to a renunciate who lives on the funeral ground who neither has wealth nor etiquette or any cultural bond." "Nobody has any idea about his family or lineage." "Shiva doesn't need any of these, o king." "Shiva is himself the source of all wealth and knowledge." "You're not so enlightened or aware to understand the greatness of his persona." "O lord... i've heard that sati is the consort of shiva." "And even today, shiva's heart awaits the arrival of sati." "Adi shakti who's born as parvati in this birth was sati in her previous birth." "Himavan... you're my devotee." "Therefore, heed my words." "Allow parvati to realise her true self." "And for the benefit of the world remove all the obstacles that arise on the path of her union with shiva." "Parvati!" "Parvati!" "Parvati!" "What's wrong with her?" "Where was she?" "Where did you find her?" "She wasn't too far away, mena." "She had fainted due to the cold." "There's nothing to worry." " I'll never let her go alone anywhere until she gets married." "Parvati... why don't you send the ambassador with the wedding invitation to vindhya?" "I've reminded himavan of the truth." "But will menavati accept it?" "Her child is more important to a mother than even vishnu." "Mena will never agree to you." "Then... whom will she listen to?" "Only parvati can make her understand." "Then goddess tell me as well how will this be possible?" "Let parvati first understand why and what is happening in her life." "Until parvati was unaware she wasn't aware of herself and her powers." "But now after entering into youth she is realising that if she has to attain shiva then she'll have to be worthy of him." "And the awareness of this can frighten her." "It can push her away from shiva." "You're absolutely right, o goddess." "Parvati." "Do you still think about shiva?" "The biggest mistake of our life living in the hermitage of sage dadhichi and markandeya for so many years." "That's why your mind has been polluted with thoughts about shiva." "But now... the time has come that you should liberate your mind of these thoughts." "Your marriage has been fixed with prince dandaka." "I don't know why your father hasn't decided the wedding date yet." "How would he know the pain of a mother's heart who has given birth to many children but only one is left." "Am i not fortunate enough to witness her marriage?" "Every mother dreams that her daughter finds a prince." "She wishes to see her daughter prosper." "Will i die without experiencing this joy?" "Mother... don't say so." "Now i'll never cause you any grief." "Then promise me... promise me, dear that you'll marry the man i say." "I promise you, mother." "Whoever you choose for me i'll marry him." "Parvati... i heard what your mother told you." "Parvati, the truth is that until yesterday, even i wanted the same for you." "Because i had promised the king of vindhya." "I'm not unaware of the truth that since childhood you've accepted someone as your husband." "You've limitless love for someone in your heart." "I... i've just come to assure you that whatever you decide on i'll always be with you." "But my decision now depends on mother's wish, father." "I'll blindly marry the man she asks me to." "My happiness lies in it." "Parvati... i'm confused upon hearing you." "I'm unable to understand the truth." "Aren't you the one who always worshipped shiva?" "The one who considered shiva her husband since childhood?" "Then parvati... why this change of heart today?" "There's been no change of heart, father." "For some time i didn't realise that i'm not just a girl but a daughter too." "I'd become selfish." "Because... no daughter can be happy after hurting her mother's heart and causing her pain." "I can't see tears in my mother's eyes." "That's why i promised her i've done my duty as a daughter... i'm doing that which any daughter would do." "Parvati is adi shakti herself who has been born to reunite with shiva." "Allow parvati to realise herself." "And remove all obstacles that stop her from uniting with shiva, for the benefit of the world." "The cave is nearby... which cave, father?" "Where shiva is lost in meditation... daughter... it's our good fortune that shiva considered our land worthy of his penance." "It's our duty now to offer him our hospitality." "It's my wish, parvati that you should carry out this task." "Right from arranging for his food to making the cave worthy of his stay will have to be done by you, parvati." "But, father it won't please mother." "Daughter... we've to stop our thought from being muddled." "In their life, every man fulfills more than one duty." "In fulfilling the duty of a daughter one shouldn't forget the duty of a host." "Shiva is our guest." "We've to take care of him." "And it'll be your responsibility." "As you say, father." "I'll personally arrange for it all." "Jaya, vijaya... where are the two of you going?" " Your highness... we're going to take food for that yogi who's meditating in the cave on the mountain." "But i'd assigned the responsibility to princess parvati." "Parvati is with the queen, in her room." "She has taken parvati along with her for something regarding her marriage." "She has ordered us to take food to the cave." "What is it, your highness?" "Have we done something wrong?" "No... no problem." "Take the food back." "And i'll talk to the queen regarding this." "Go on." " Ok." "Parvati." "You've disappointed me, daughter." "I told you to take food to shiva." "And you gave this job to jaya and vijaya?" "Mother called me for some important work." "I couldn't refuse her orders that's why... you couldn't refuse your mother's orders that's why you disobeyed your father." "No, father." "Please don't think so." "You're aware of the truth." "But... i didn't wish to hurt mother again." "Parvati." "I can hear dilemma in your voice." "What's the truth?" "The truth is what you're saying, father." "Yes, i'm in a dilemma." "Doubt resides in my heart." "I'm afraid too, father." "Afraid?" "Why?" "About what?" "I don't know." "Since i remember i've only thought of shiva as my husband." "Even sage dadhichi always said so." "But now when i'm about to meet shiva then i'm doubtful about myself whether i'm worthy of him or not." "Will he accept me?" "What if i hurt him again?" "No, father." "My heart isn't ready to meet him yet." "Why do you think so?" "I don't know, father." "I'm feeling very worried." "I've to find the answer to this question." "Who will answer this?" "Even i can't answer this question." "But i'm confident that lord vishnu's instruction cannot be untrue." "If he has said that your marriage to shiva is definite and that it's destined then i'll bow my head and accept it." "And believe it too." "Forgive me, your majesty." "Sage dadhichi has arrived." "Sage dadhichi?" "I told you, dear." "It appears that lord vishnu has sent sage dadhichi here, to guide you." "Go, dear." "Go and welcome him." "What are you thinking about, lord?" "I was thinking about parvati." "Adi shakti in the form of parvati is having to face many emotional turmoils." "Because of which her thought, her life is in chaos." "It's worrisome, lord." "I've sent sage dadhichi to help parvati." "She'll have to prepare herself to meet shiva." "And sage dadhichi will help her do so." "But... - but what, o narayana?" "But it's possible that parvati might not be able to understand him." "Why so, my lord?" "Because desire isn't yet born in parvati's mind." "More than the meaning of the truth and its consequence it's the desire towards the truth that's important." "As long as parvati isn't desirous till then, sage dadhichi's voice will not be effective on her." "Don't worry, narayana." "I'll enter her heart and inspire her to ask suitable questions to sage dadhichi." "And that she receives worthy answers to them." "I, goddess lakshmi will grant the wealth of desire to parvati." "By touching my feet please don't make me a sinner, mother." "Are you doing well?" "I wasn't until now, o sage." "But on seeing you, i feel that, hopefully, everything will be well." "Not hopefully, mother." "It'll surely be well." "That's the reason for my visit." "You hold a special place in my life, o sage." "Whenever i've been faced with a difficult situation or problem you've always come to my aid." "Even today, it's the most difficult day of my life." "And today again, you've come to help me." "It's my good fortune that i can help you." "But today... i haven't come here by choice." "Lord vishnu has sent me here." "Tell me your problem." "I'll try my best to find a solution to it." "The problem is that i myself don't know whether the path i've set on is worthy of me or not." "You've always told me that i'm born to marry shiva." "Then why do the clouds of doubt engulf my mind?" "Why does the question repeatedly arise that whether shiva will accept me?" "Am i worthy of him or not?" "The truth is that in this world, nobody is worthy of shiva." "But there's also a truth that the heart that's illuminated by truth there's geniune devotion and love that person can become worthy of shiva." "Is it true?" " Absolutely true." "I've come here to show you the path to become worthy of shiva." "Please come." "Along with desire the ease of knowledge is important." "The secrets of the universe are mysterious, confusing and vague." "It's beyond the understanding of man." "The time to make parvati realise the truth of the universe is here." "Sage dadhichi has gone to meet parvati." "You're the goddess of knowledge and wisdom hence i request you to help parvati on this task." "Your help will enable her to understand the secret of the universe very easily." "Sure, my lord." "I'll seat myself on sage dadhichi's tongue and through his voice i'll speak to parvati." "So that, sage dadhichi's voice will be more meaningful." "And parvati is able to understand better." "The knowledge that i'm going to tell you about was received by me from shiva himself." "Through you ordinary men will be able to learn it as a 'sutra' (short texts)." "This is one of the three primary purposes of your life." "O goddess... you're adi shakti." "But having been born in a human womb you've forgotten your true self." "That's why you're engulfed by fear and anxiety." "But every soul is a form of that universal soul." "By removing the sense of individual distinction from your soul and by accepting fear as a state of mind you'll enter a higher state of consciousness." "And you will be able to derive pleasure from your proximity to shiva." "Because shiva is the universal soul, himself." "But, o sage what is the way to break the shackles of fear?" "Awareness of one's true self." "'Tatvamasi'." "By awareness of 'tatvamasi'." "Meaning that shiva, the universal soul, exists within me." "I've to find him within me." "Through this knowledge man's soul liberates itself from all other senses." "Man's mind through its endless thoughts keeps supressing that awareness." "Years of culture has been refining these five senses even further." "O sage what are these five senses?" "What's the path to liberate oneself from them?" "Sage, you've explained everything to me in detail." "But... what's the reason that i'm still unable to free my mind of fear?" "Don't ever be in doubt." "This is the difference between knowledge and experience." "Whatever i told you is just formless knowledge." "Only through the presence of shiva will this formless knowledge gain shape." "And that moment will be your realisation of being adi shakti." "This isn't the time to hesitate or be in doubt." "Shiva awaits you in that cave." "And when the goal is shiva itself then why fear the obstacles in the path?" "Accept this bilwa leaf, o mother." "The power of this bilwa leaf will open the doors of that cave to you." "Go on, mother." "The entire universe waits for your union with shiva." "All the creatures of this universe are separated from that universal soul." "When the soul realises the truth about itself... seeing the troubled world moving away from shiva the heart grieves then in that heart the desire to reunite arises." "The power of this bilwa leaf will open the doors of that cave to you." "Shiva awaits you in that cave." "And when the goal is shiva itself then why fear the obstacles in the path?" "Go on, mother." "The entire universe awaits your union with shiva." "Where have i come?" "There are many types of perceptions." "The stone is the external description of the idol." "The one that we can see." "The final description is within us." "The entire universe resides within us." "All the three dimensions are hidden inside." "Past, present and future." "It's all within us." "Sati!" "Sati, look!" "Ignorance is the highest of the five distinctions." "Every man fails to emerge out of 'annamaya' the dependency on food and water." "Every layer is like the whirls of a flower the more the petals open up the greater is the fragrance of awareness that emanates." "Awareness of the 'muladhara' chakra helps one emerge from 'annamaya'." "This is the beginning." "And this is the goal." "If you can free yourself from 'annamaya' first then you'll reach the level of 'pranamaya'." "This is the dependency nurtured by air." "And most people due to the influence of the breath are engulfed by ignorance and ego." "Awakening the 'swadishthan chakra' located on the navel will lead to liberation from 'pranamaya'." "I'm not his devotee, but his consort." "Shiva is mine, only mine." "If he wishes to talk to me then he'll come to me." "Next is the 'ubigmaya' through which man falls prey to jealousy." "Envy is an indistinguishable part of his life." "By harming you they wish to cause me pain." "Shiva is tricking you... in this civil society established by prajapati this is considered despicable." "I've hurt you enough, not anymore." "When near the 'hridaya chakra' man can control his opinion and thoughts to an extent." "It can help realign 'vigmaya'." "And finally, 'anandamaya' which is composed entirely of the truth." "Such a man, in all circumstances is free of emotions and remains calm." "Why do you keep appearing before me?" "Why don't you say that all this is meaningless?" "Who are you to protect me?" "What relationship do we share?" "I don't need your mercy." "You called me unworthy the other day." "But today... today, sati considers shiva unworthy of her." "Shiva is just a stone for me." "Only a stone whose place is neither in my heart nor in my house." "You're on the other side of the funeral ground." "And i... on this side." "This boundary of the funeral ground will remain between us forever." "I don't know all that... i just know that if you love me then you'll surely attend the ceremony with me." "Or else, tell me... tell me that you don't love me." "I'll fulfill all this after the ceremony." "A woman's stubbornness is the cause for destruction, sati." "If i said that we'll go, then we'll go." "We'll surely go!" "Don't insult my father." "It's impossible for us to attend the ceremony." "Alright... if you don't wish to come along then i'll go alone." "You're under my oath, you won't stop me." "If going there will bring me harm then you can come after that." "What bond do we share?" "You're under my oath... no!" "No, my lord isn't like this." "He has... he has always kept me away from sorrow." "But i never understood his love." "Going there will only bring you harm." "Harm!" "You speak as if he's not my father but my enemy." "You've learn to act very well from that fraud!" "I don't have any right to live after hearing so much." "I'll have to liberate myself from this curse." "This body has to be destroyed." "Sati... the 'anandamaya chakra' located in the throat guides the anxiety and restlessness inherent in man." "In the forehead, lies the most powerful 'chakra' 'agya chakra'." "By guiding the sixth sense it brings the soul closer to the universal soul." "When man becomes capable of absorbing both joy and sorrow without reacting then he attains eternal bliss." "You went through so much, o shiva to attain me." "You showered limitless love on me but i doubted that pious love and insulted you in my desire for my father." "Your love is superior than mine." "But if you love me so much then why didn't you call me to you?" "Why did you wait so many years for me?" "How do i seek an apology for something which was beyond my control?" "I was bound by social values." "But now with renewed respect in order to fulfill my duty as a wife i surrender myself to you again." "Please open your eyes now, o lord!" "The pain cause to you was because of my unworthiness in the past life but in this birth i surrender myself in order to undo the harm done." "Please open your eyes, o lord." "And tell me how do i become worthy of you?" "I'll make all attempts possible and impossible." "Alright, my lord." "I'll find my own way to become worthy of you." "But please look at me once." "I'm so foolish." "In my haste, i forgot my duty as a wife." "You're meditating without food and water for years." "And i didn't even ask you for food." "I'll bring food for you right away." "You can open your eyes after that and eat." "And then if you wish you can even look at me." "Mother... mother... didn't you recognise me?" "Mother, please stop!" "Mother, my eyes are blessed to have seen you in person." "Nandi!" "How can i forget you, nandi?" "You were the one who understood my love for shiva." "And you have transformed into stone!" "Parvati... do you recognise me?" "Sister... sister... don't let your sorrow flow as tears." "Your sorrow will be your biggest strength." "Now, parvati will have to appear in the form in which she was separated from shiva." "You're a woman, you've to appear in bridal finery." "In the past birth, shiva had given you seven vows for marriage." "For the fulfillment of those vows shiva will have to break his penance." "I'll do anything to relieve the lord of his grief." "Kamadeva... you'll have to awaken shiva." "You'll have to give rise to the feelings of love beauty and desire in his renunciate heart that he should accept worldly life." "And you'll have to do this today itself." "Because mother parvati is going to shiva as a wife." "And you'll have to help her in this task." "Indra, what are you saying!" "This is impossible." "But you'll have to make it possible, kamadeva." "Alright, o king." "Goddess parvati... in order to help you succeed my arrows of love beauty and desire will assist you." "I'll begin this work with my 'navmalika' arrow." "It appears as if the entire universe is with me in my success." "Parvati the fragrance of all the flowers of the universe are in this." "When you offer these flowers to the lord then his mind will be immersed in its aroma and desire will be sown in his inner consciousness." "This 'arvinda' arrow will create that path walking on which, mother parvati, will reach shiva." "O demi-gods and celestial beings!" "It appears that all of creation stands by mother parvati today." "With my arrows i'll have to fill this desolate cave with love and beauty." "Kamadeva has used all his four arrows." "Only the arrow of enchantment remains." "And mother parvati has neared shiva." "Now, i'll have to use my 'tapana' arrow." "It appears that the time for shiva and parvati's union has arrived." "O lord... i accept you as my husband, again." "You'll have to break your penance and bless me, today." "You'll have to uphold the vows taken during our marriage." "If today... if you don't do so, today then i vow that i'll sit in penance, like you." "My lord!" "Please wait, my lord." "Where do you go, leaving me, o lord?" "I've been waiting for you to break your penance." "Why do you look at me like this?" "Who are you?" "You didn't recognise me, o lord?" "I'm parvati." "Your parvati." "Whoever you are i don't know you." "I don't share any body with you." "Don't say so, my lord." "We don't share a bond?" "Our bond is eternal." "No, lady." "The one you search for, isn't me." "It's just your imagination." "No, my lord." "Please don't say so." "Recognise me, i'm your parvati." "The love for which you went into a meditative state is me." "The peace for which you renounced the world that's me." "The anger that rages within you i'm the purity of that anger." "The energies that emanate from you i'm the source of it all." "Stop, lady!" "Don't try to misguide me any further." "The meditative state i was in has nothing to do with beauty and grace." "Renunciation shares no bond with love." "There's a bond, o shiva!" "Without love, there's no penance or meditation." "Neither enlightenment, nor renunciation." "Recognise me, o lord." "I'm the sati because of whom, you were insulted many times." "I'm the sati, because of whom you were bonded by marriage." "I'm the sati, who lost her right to be your consort because of her mistake." "I'm the sati who, despite your warnings for the sake of your rights sacrificed her body in her father's altar!" "I'm the sati whose grief, angered you and devastated the life of my father, prajapati daksha." "I'm the sati, because of whom, you abandoned the world." "And today, the same sati stands before you in the form of parvati." "Accept me, o shiva." "Lady, if you're sati in the form of parvati because of whom i'm lost in meditation if you're the form of sati, because of whom i opened my third eye then i don't accept that sati in the form of parvati." "Not at any cost." "Please stop, o lord!" "Please stop!" "You can't leave me like this." "Please stop, o shiva!" "Please stop... please... o lord!" "Please stop, o lord." "My lord... where are you going?" "Mother parvati is inside." "How can you leave her?" "The woman you talk of, nandi i share no relation with her." "No, my lord." "It's not possible." "She's my mother." " Nandi!" "She's not your mother." "My lord... she has gone through pain and trouble to reach you." "Accept her." "Accept her, o lord." "Never!" "O lord... mother parvati will attain you." "But this nandi can never abandon you." "Never." "O lord!" "O lord!" "Where are you?" "!" "O lord!" "Where's my lord, kamadeva?" "He had come here on the orders of indra to help you." "Where is he?" "Even shiva isn't here." "Where's shiva?" "He left." "And my lord... something untoward happened." "The fire of shiva's third eye reduced kamadeva to ashes." "No!" "This isn't possible!" "This can't be true!" "No!" "My lord!" "My lord!" "My lord... this can't be true." "You can't leave me like this." "You can't... we're all blessed to see you in person after so many years." "O shiva... it was necessary to break your penance." "That's why, we sent kamadeva." "This has happened with our permission." "Whatever happened here today and whatever happened earlier we seek your apology for it." "What do you apologise for, narayana?" "Today, you all have made the same mistake that you did years ago." "I'd told you all earlier too that i'm not meant for marriage." "But you all insisted on my marriage to sati." "And bound me to sati by marriage." "The world saw the consequences of that." "And today, by breaking my penance kamadeva repeated the mistake." "O lord... mother parvati is still in the cave." "She has been born again to live with you." "There's no mother here, nandi!" "The idea of my marriage is obsolete." "If bonding brings happiness it also brings along the burden of sorrow." "O shiva, to ensure sustenance of creation and to give it balance your union to parvati is vital." "Moreover, parvati is sati." "Nothing has changed, o shiva." "She's willing to accept all your conditions." "I've recognised her, brahma." "And that's the reason i can't accept sati's re-entry into my life." "You're the supreme yogi, o shiva by bestowing the knowledge of yoga upon parvati you can make her worthy of you." "Under your guidance she can become worthy, o lord." "I don't wish to guide anybody, brahma." "My principles are based on renunciation." "And i'm following them." "Of course we became a little restless." "Shiva's isn't mentally stable yet." "After the death of kamadeva shiva has become all the more resistant to marriage." "The moment that could've been very joyous for parvati has turned into a moment of extreme pain due to shiva's anger." "You can't leave me, it's a lie!" "It's false!" " Have courage, rati." "Gather yourself." "It's all because of you." "You!" "In order to unite you with your husband i lost mine!" "Why did you leave me and go, my lord?" "I tried so hard to stop you." "So hard!" "But you... you didn't listen to me." "How can i live without you?" "I won't live." "I won't live without you either." "Rati... this isn't right." "My husband never wanted to use his arrows on a yogi like shiva." "It was only because of you that my husband fell prey to shiva's fury." "I curse you, o indra!" "Your throne will never be stable." "The clouds of insecurity and threat will always engulf it!" "Sister... you're also a reason for my plight, parvati." "You've deprived me of the pleasure of motherhood." "You'll have to bear this misfortune, too." "I curse you that you'll never have the pleasure of bearing offsprings." "Never!" "Don't do this, o mother!" "Don't do this!" "I share you grief." "You have the right to curse me." "Rati." "This curse will cause the end of creation." "If parvati doesn't bear children then it'll never be possible to slay tarakasura." "Rati... in all the beautiful things of this world... in fragrant flowers... in love and art, kamadeva will always be present." "It's my boon." "He'll also be reborn." "In my avatar as krishna he'll be born as my son pradyumna." "He'll marry you again." "Rati... you've to now rectify your curse." "I can only reduce the effect of my curse, o lord." "Parvati will surely be a mother but she'll not be able to carry her children in her womb." "I accept your curse." "And my blessings will always be with you." "You'll again be kamadeva's wife." "And unlike me you'll never be abhorred by your husband." "For the benefit of mankind adi shakti will have to be born in a human womb and marry shiva." "But every human's birth is tarnished by impurity." "Goddess parvati should be free of all impurities." "But mother parvati must be aware of it." "In the absence of a teacher no knowledge is possible." "Even parvati needs such a teacher who will enlighten her on the intricacies of meditation." "O lord... who can be the best teacher for parvati?" "That great man who dedicated his life to devotion and worship." "And there's none worthier than you, o son of brahma." "Praise be to narayana!" "O lord, i'll carry out your order." "I accept the responsibility for shiva and parvati's union." "No, parvati, leave it." "It'll sting you, it's a scorpion." "It stung you, didn't it?" "I told you... it's a scorpion, it is his nature to sting." "Why did you take it out of the water?" "Look!" "Mother... as a scorpion, if it cannot give up its nature of stinging then how do we give up our nature of protecting the weak?" "I couldn't understand that it's in your nature to love shiva." "And nobody can give up their nature." "What is it, mother?" "Why do you look at me like this?" "I've tolerated the sting." "See, i'm fine now." "And the pain that we gave you you tolerated that too, didn't you?" "I've realised everything." "Despite my prohibiting none can stop you from uniting with shiva." "Nobody can stop you!" "Marry shiva." "But will you be happy with him?" "My happiness and well-being lies with shiva." "I was born to marry shiva." "Nandi... mother's love made her stand in front of shiva." "But they couldn't unite." "That's why, in order to enter shiva's heart mother parvati will have to follow the path of devotion." "Then what's the problem in it, sage?" "The lord is already god to her." "In terms of love not devotion." "You're the only one in this world who can bring parvati on the path of devotion because your surrender towards shiva and parvati is enriched with love and devotion." "That's why, nandi you'll have to inspire parvati to tread on the path of devotion." "Alright, sage." "I'll do anything for the union of my master and mother." "Praise be to narayana!" ""I wander lost in your thoughts..."" ""...i sing your praises..."" ""i'm immersed in your love..."" ""...you are my god."" ""I'm immersed in your love..."" ""...you are my god."" ""I'm immersed in your love..."" "cowherd!" "Which love ballad do you sing?" "O lady... i'm singing a love ballad and losing myself in my lord's devotion." "What are you saying?" "What does love and devotion have to do with each other?" "Lady... there's no relationship greater than love and devotion." "It's that divine relationship which transforms the lover into god and god becomes a lover." "O lady... worldly love can be defeated but when love takes the form of devotion then it's beyond the limitations of victory and defeat." "How is this possible?" "How can you leave the path of love and take to the path of devotion?" "O lady, neither is there anything to leave nor to take... you just have to accept your lover in the form of god." "Then love transforms automatically into devotion." "And as soon as love turns into devotion then the lover who is bound by devotion..." "Can we attain our goal by walking the path of devotion and love?" "Yes." "Merge love and devotion and there will be nothing in this world that will be unattainable." "Thank you for showing me the path to attain my lord." "I'm blessed today, o mother!" "I could be of some use to you." "Just watch, mother this path of your devotion will unite you with shiva." "You'll surely unite." "Praise be to narayana!" "Salutations, mother." "Salutations, o sage." "Sage, i've found the path to my lord." "Henceforth, my shiva is my god and i'm his devotee." "Even shiva himself cannot stop the union of god and his devotee." "And mother, in this task i'll be with you at every step." "But sage, what do i have to do to accomplish this?" "Mother... there are 16 impurities in the human body." "And to remove these 16 impurities you'll have to fast for 16 mondays." "And that's because monday is the chosen day of shiva." "It's his favourite day." "I've full faith, o mother that your union with shiva is certain." "And mother, if this happens then for many eons to come this penance will be known as the '16-monday penance'." "Not just that, for many ages every woman to attain her desired husband will perform this penance under your guidance." "It's impossible to attain shiva against his will, parvati." "I'll ruin all your attempts." "But why, o lord?" "Why this injustice towards mother parvati?" "Like all your other devotees she wishes to worship you." "And my lord how can you take away the right of worship from a devotee?" "None is beyond limitations, nandi." "Not even god." "Even god has his limitations." "What could be more compelling for god to stop his devotee from worshipping him?" "I'm about to begin your worship, o shiva." "Bless me that it's concluded successfully." "God himself is against this worship." "It's a difficult test, mother." "Sister... iord, it's you!" "It's the duty of every brother to help his sister, o sage." "Tell me, brother." "What's the job?" "I'm a traveller." "I was feeling thirsty, hence i came here." "Can i get some water?" "No, sister." "I'll accept the water only when we share a relationship." "You've called me your sister." "The bond is already established, brother." " Then tie this sacred thread on my wrist and prove it." "I'm blessed, o lord to bear witness to this holy incident." "In the coming age this day will not be known only for shiva and parvati but also for the love between a brother and sister, o sage." "It appears that you're making a shiva linga." "But you're unable to make it." "Let me help you." "I'm your brother now." "Hence, it's my duty to help you." "Allow me to fulfill my duty." "Narayana!" "What have you done, narayana?" "!" "How can one break the shiva linga made by you?" "O mother... the shiva linga is complete." "Let's begin." "Who are you?" "You made the shiva linga so easily." "An ordinary man cannot do this." "Who are you, who has come to help us?" "Your brother." "Isn't this enough?" "There's no place for secrets between a brother and sister." "I wish to know your true identity." "Will you not fulfill this wish of your sister?" "As you say." "Narayana!" "You're my brother?" "This brother will always be with you." "You'll surely be worthy of shiva." "Narayana... i request you to promise this sister that henceforth no attempt should be made to take me closer to shiva." "I don't know whether i'll attain shiva or not but in my attempt to attain him even if this body ends then i'll assume that i've attained him." "As you wish." "In future, no god will help you." "But... this shiva linga has been made now." "You can begin your worship." "The shiva linga, even if made is incomplete." "Your help has turned my victory into a loss, o narayana." "Your behavious surely differs from that of sati, parvati." "You've won despite losing." "You've won, parvati." "Parvati!" "Calamity has befallen, dear!" " What happened, mother?" "Serpent-king kandru has attacked our kingdom and enslaved your father." "And he has sought your marriage to his son in return for his life." "Mother, nothing can go wrong as long as shiva's there." "This situation has arised because of shiva." "Because of him... it's not his fault, mother." "He can never do bad to anybody." "And us, being innocent he'll surely help us." "Come, mother." "I've said it once... as long as i live my daughter parvati will not marry kandru's son." "Stop!" "Free my father." "Surely." "If you agree to come to the underworld with us and marry the son of serpent-king kandru then i'll surely spare your father." "If this is the only option then so be it." "Soldiers!" "Arrange for a palanquin for parvati." "O shiva... i've dedicated my entire life to you." "If i'm going to the underworld with these demons today then i'm not alone, i'm taking you along." "With you as witness, i'm handing over the responsibility of liberating me and my family of all problems." "If any harm befalls parvati then you'll be party to it." "Because every act of mine is dedicated to you." "I bow to thee, o shiva." "I bow to thee, o shiva." "I bow to thee, o shiva." "I bow to thee, o shiva." "I bow to thee, o shiva." " Use force!" "Guards, come forward!" "I bow to thee, o shiva." "I've to protect the sons of tarakasura from shiva's rage." "O shiva!" "Please stop!" "O lord... as their teacher i apologise to you for their foolishness." "O shiva, please forgive them." "Lord, please trust me." "They'll never ever dream of doing such a thing again." "Yes, my lord." "Fools!" "Do you even know what you were about to do?" "You all have done such a thing today that you're not even fit to seek the lord's mercy." "O lord... please forgive them." "Forgive them." "Their sins aren't worthy of mercy." "But i spare them on the request of a teacher like you." "Or else... this is shiva i'll marry him." "Who are you, o lady?" "I'm parvati." "Your parvati." " Whoever you are, i don't know you." "I share no relation with you." "You do have a relation, o lord." "There's neither any penance without love nor meditation." "Neither consciousness nor renunciation." "No calamity can befall us as long as shiva lives." "He'll surely help us." "Forgive me, parvati." "I was late to arrive." "I promise you, parvati." "I'll accept you." "I'll accept your penance." "I'll personally take you on the path of truth." "Parvati's penance is shiva's penance, too." "Praise be to narayana!" "O lord... i'm blessed to hear your words!" "Shiva is himself, the teacher of the mother." "There's nothing more joyous than this." "I've agreed to be parvati's teacher, only because the sustenance of creation is completed successfully." "I'm aware, o sage that you're not very capable at maintaining secrecy but i request you, o narada that upon regaining her senses parvati shouldn't come to know that i've agreed to be her teacher." "Parvati should realise it herself." "Yes, do tell her that the solution to one's problem, lies within oneself." "Then lord, will you leave without meeting her?" "I'm always with her, sage." "But there's still time for the meeting." "Until then, we'll meet as student and teacher." "By having shiva for a teacher, not just mother but all creation will be joyous." "Praise be to narayana!" "Narada tells parvati that shiva came to protect her." "Mother before leaving, he said that man kind find the solution to his problems within himself." "Meaning, the solution to all of man's problems is he, himself." "'Om... '" "no, sati." "Attempt again." "I can't do it." "I'll do this only after attending the ceremony." "I've found the solution, o sage." "The panchagni penance that i couldn't complete as sati i'll complete it now." "Start your penance soon, dear." "With both your blessings and wishes my confidence has been boosted." "I'll proceed to the amarnath cave soon in order to complete my penance." "O lord!" "Parvati should know that beauty can be ugly too." "And creation doesn't distinguish it." "I'll impart the knowledge of both beauty and ugliness to parvati." "Will you all help me in it?" "These flowers are dear to shiva." "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Thank you for bringing the shiva linga here, o lady." "We'll begin its worship now." "Wait!" "What are you doing?" "Why do you offer these impure things to this holy shiva linga!" "How can these be impure, lady?" "Everything in this world has been made by shiva." "You're doing things against the norms of worship." "Shiva isn't offered meat and blood but milk, dhatura flowers and bilwa leaves." "And hymns are chanted in his honour." " Enough, lady!" "Don't insult me by interrupting my worship." "I don't know any hymns." "This is my method of worship." "Alright." "Then worship your shiva linga the way you want to." "All shiva lingas are one, o lady." "Neither yours, nor mine." "I can't bear this discrimination anymore." "Please let me offer my oblations." "Shiva will not accept these impure things you offer." "Would you like to see?" "Hear that, shiva?" "This woman says that you won't accept my oblations." "Look, i've brought tender meat for you." "Accept it... accept it, o shiva." "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "Praise be to shiva, the supreme!" "I apologise for the interruption in your worship." "But i request you to allow me to offer my oblations." "She has realised her mistake." "And it's the culture of shiva's devotees to forgive." "Come, lady." "Just like how you accepted their oblations similarly, accept our worship too, o lord." "What is the reason that shiva accepted your impure meat but not my flowers?" "Worship is not by method but by devotion and surrender." "I too have followed many methods any systems, like you." "I performed penances... for years, i tolerated hunger and thirst and remained immersed in devotion." "Only then i understood the meaning of this sense." "What sense?" "The sense of liberation from the body." "The sense of awareness about destructibility." "The sense of equality in the world." "You offer flowers to god considering them to be holy and beautiful." "But leave them for a day and they'll begin to stink too." "The flowers will wither." "Bathing will help you cleanse your outside but what about the dirt that your body creates constantly?" "The differentiation of purity and impurity, is an illusion!" "Whatever exists in this world belongs to shiva." "And what belongs to shiva, is shiva." "Meaning it's pure." "I've received knowledge of this truth, today." "I've to liberate myself from this sense of the body." "O teacher, who granted me wisdom please bless me that i may attain my goal." "Praise be to shiva, the supreme!" "Even though you're not near me but your idol resides in my heart." "As your memory in this place as my witness i being my penance." "Parvati, after your penance, this place will be known for our penances." "And for all our devotees, this place will be known as a pilgrimage." "I seek your blessing to attain you." "O agni my panchagni penance cannot be completed without you." "Please appear and help me." "On one hand, mother parvati goes deep into meditation." "And on the other hand for the benefit of the world and to liberate the souls of his ancestors in search of pure water king bhagiratha approaches shiva." "Only the waters of ganga can liberate this world of its sins." "It can uplift this world." "It can transform earth into a holy land." "Go on, bhagiratha proceed to brahmaloka." "Ganga resides there." "Brahma will surely help you attain your goal." "O goddess... i request you... only you can uplift the world." "King bhagiratha i can't help you in any manner." "Ganga... ganga... your life is for the benefit of the world." "Or else, you're without purpose." "Even shiva wishes the same." "He has asked me to request you to return to earth in order to bring back life." "If this is what shiva wishes then i'll surely go to earth." "But... only shiva possesses the capability to channelise my force and make it worthy of the earth." "Or else, my extreme speed will devastate the earth." "My return to earth will only be possible when shiva himself receives my full force." "Go on, bhagiratha tell ganga that in order to receive her on earth and to channelise her force i'll receive her in my locks." ""Immense power, tremendous speed..."" ""...shiva received her on his head."" ""The destroyer of sins, the vanquisher of woes..."" ""...she's bhagiratha's blessing..."" ""the places that lie on your course..."" ""...are all known as holy pilgrimages."" "O shiva, by your blessing the entire world will receive the fruits of my efforts." "For this, i bow to thee on behalf of the earth and its creatures." "Your efforts have made me aware of ganga's need on the earth." "In the coming future ganga will also be known as bhagirathi, after you." "Ganga's significance is beyond compare." "The capabilities of this water is to annul the effect of all ill-effects on earth." "Those who interrupt the workings of the world in the future, through the powers of the ganga will fall prey to a great war." "Man will keep getting submerged in his material life consequently penance and meditation will become rare worship and devotion will lose their value in such times, only ganga will continue to guide man towards his true goal." "I seek your promise that ganga's purity and sanctity will be your primary duty." "I promise you, o lord that i'll never let ganga's purity diminish." "And i'll keep men aware of the greatness of the ganga forever." "O goddess... accept my salutations." "I've come here only through your efforts, o king." "I request you to decide my course." "Wherever you go my waters will adopt that course." "The fire of parvati's body has conquered the fire element." "The five elements that a human body is composed of parvati has liberated herself from one of those elements." "What other test does mother have to give, o lord?" "Conquering the water element." "This is extremely important, nandi." "Water is used to annul the influences that can harm the earth." "After parvati completes this step she'll attain mastery over all the five elements which is the basis of all creation." "O lord... the human body has its limits." "It has its limits of tolerance." "What if mother's body gives up while pursuing such rigorous penance, o lord!" "Until i complete my penance i'll only eat vegetation." "By sacrificing everything you've added a new chapter to your penance, parvati." "Henceforth, you'll be known as 'aparna' (sacrificer)." "To offer it to the shiva linga i don't have the strength left to reach the bilwa leaf and water." "Finally, it's time for the union of shiva and parvati." "Uma... aparna... parvati... then you... i've tormented you by forcing you to perform such rigorous austerities, parvati." "But even i was aware of every moment of pain that you bore." "The past is considered the past because it has passed." "And what has passed why should we talk of its pain and repentance?" "We're about to begin a new life." "By keeping you away i kept myself away from the joy of uniting with you." "But after the completion of your penance i accept you this very moment." "I wish to express my gratitude by performing a special ceremony in your honour, o lord." "You've helped me in my penance and have remained the witness to it, o doves." "I grant you the boon that you'll reside in this pious and holy amarnath cave till the end of time." "What is love?" "Tell me, o shiva." "Please tell me the secret of love." "What is its true form?" "What is its future?" "You're playing the role of my teacher." "It's your duty to enlighten me about love." "Tell me, o holy one." "What is love?" "You're asking me this, parvati?" "What's the secret of love?" "What is its form?" "You've awakened various forms of love, parvati." "I've experienced different forms of love because of you." "Your answers are buried in your questions." "Can you describe the various forms?" "In the form of sati, when you gave up your life and went away from me my life my world my duty all became meaningless and baseless." "Tears streamed from my eyes." "By distancing yourself from me you distanced me from myself, parvati." "For our reunion this universe attempting every possibility attempting every ploy our true love is the reason for this." "Your rebirth in the form of parvati and compelling me to denounce my renunciation and my being compelled is nothing but love." "In the future, through your various forms you'll establish new forms of love." "Which form, o shiva?" "Please list them." "Whenever, in the form of annapurna you'll satisfy my hunger without any limitations or as kamakhya when you'll desire me." "Then it'll be an experience of love." "Whenever, for entertainment you'll defeat me in chess even then, i'll be victorious." "Because the joy on your face at that moment will remind me of the completeness of my duty." "This is love, parvati." "Whenever you'll take up weapons and assume the form of durga and protect and fight for me then it'll be an experience of love." "Whenever, in the form of kali, you enact the dance of death and trample my body and you'll realise your mistake you'll stick your tongue out that's love, parvati." "Parvati... whenever you'll repeatedly submit to me and make me realise that i'm worthy of you... when you'll reflect my true self and assume the form of my reflection it'll be love, parvati." "Has it quenched your thirst and curiosity towards love?" "Now there's no obstacle no difficulty in our union, parvati." "I'll marry you today itself." "You're my consort." "Our devotees in kailash await the commencement of our married life." "Come, parvati... the time has come." "Parvati... i can't go to kailash with you." "I can't begin our married life." "I can't marry you." |
Measurement of particle deposition patterns in a human nasal airway model using a Charge Coupled Device imaging system.
Charge Coupled Device (CCD) imaging technology is being applied to measure the spatial deposition patterns of inhaled aerosols in the nasal airway. The new technology allows the experimenter to measure local particle deposition patterns of different sized fluorescent particles at variable flow rates in a full-scale multi-section replica of a human nasal airway. Images of fluorescing particles on the exposed model have been taken with a CCD camera and combined to form three-dimensional particle deposition patterns. Total particle deposition efficiencies and particle deposition patterns have been measured in the nasal airway for 6 microns diameter particles and compared with published inhalation data. |
Chromium overlays not properly mapped
The FlashControl Chromium plugin opens a tool overlay when clicking on its icon on the left of its URL bar. First screenshot shows it does not appear properly, only the left of the overlay is drawn. The second screenshot was not cropped, which means (by Gimp screenshot options) that this overlay is in fact in its own window. This one was made by moving the pointer, which unveiled buttons while flying over their intended space. |
June 11, 2018
Waiting For Little Rocket Man
While we wait for the meeting of the Two Dictators let's pause for a moment and ask this - what knucklehead laid off the guy who was hired to stand near Wild Bill Clinton with a thorazine tranquilizer gun? Matt Drudge just can't let go, with this link to Old News featured prominently.
Comments
Hubs first post-retirement job was overseeing a section of gates at Charlotte Stadium. He said the Mexican soccer fans were wild and crazy - literally. Had no conception of assigned seats or paying for kids in tow. Many brought huge drums they'd set up on the outside concourse which they banged loudly throughout the game. All feigned ignorance of English of the "Don't stand against the rail" variety. Can't imagine how they'd be at a World Cup event.
Disney has gone full SJW. I'm sure Dumbo will be fighting racial discrimination and/or advocating for animal rights. The villain will probably be an evil white male circus owner or ringleader. Wish I were wrong.
the "blue wave" team will be doing back flips over this. A Dem won the special election state Senate seat in WI. A couple thoughts: it does not change the Senate majority, it only lasts until November (4 months), the Senate is not expected to meet until after November.
People overlooked this story at the time, but Corey Stewart accepted – and then publicly defended last year – an endorsement from a prominent neo-Confederate who protested a statue to a black tennis star and did a racist attack on Nikki Haley.
I don't know though why the writer of that article is unaware that anyone go go to nap.edu and register in order to be able to download report itself for free. It's only the print copy that costs money.
Corey Stewart came on the political scene here in Virginia, being VERY outspoken against illegal immigration.
He also turned DOWN fed money, which was unheard of then, because it would be a one time deal, but would commit his constituents to more debt in the long run.
Instead of buying into the phony SJW angst about Virginia's history....
how about making Democrats explain their association with a baby killing, baby scalp selling, multimillion dollar chain business in the here & now?
You're against statues of Robert E. Lee?...fine.
We're against slaughtering our current HERITAGE & FUTURE.
Brian Fraley @Dailytakes
14m
Take that Supreme Court. Still waiting on you decision on the maps:
So, to follow the Holder/WisDems logic, Gerrymandering kept AD42 in GOP hands. But what, then of SD10 and SD1? Bottom line, the compact, contiguous districts in Wisconsin all make up a 'fair map.' Perhaps fewer seats than ever are 'locks' --especially this year.
So funny to watch the Fake News, especially NBC and CNN. They are fighting hard to downplay the deal with North Korea. 500 days ago they would have “begged” for this deal-looked like war would break out. Our Country’s biggest enemy is the Fake News so easily promulgated by fools!
Fun in Yemen: "The liberation of the port is the start of the fall of the Houthi militia and will secure marine shipping in the Bab al-Mandab strait and cut off the hands of Iran, which has long drowned Yemen in weapons that shed precious Yemeni blood," the Arab-backed government-in-exile said in a statement.
Pimp and brothel owner Dennis Hof won a Republican primary for a Nevada Legislature seat on Tuesday, ousting a three-term incumbent hospital executive.
He celebrated his victory alongside famed Hollywood Madam Heidi Fleiss. Hof is most known for starring in the HBO reality series "Cathouse," which focuses on the lives of workers at Hof's Moonlite BunnyRanch.
After defeating incumbent James Oscarson, Hof is favored in his race against Democrat Lesia Romanov in November due to the Republican lean of the district.
A Donald Trump supporter, Hof pointed to the president as his guiding light.
Not really. At the state level there would be three governments where there was one, politicians and employees. What? You don't think government employees would be reduced to take into account the smaller size? |
Kendall Jenner's $55 Sneakers Are Perfect With Skinny Jeans
Kendall Jenner emerged in a characteristically chill outfit this week, and our eyes went straight to her feet, per usual. While she's undyingly loyal to her white leather Kenneth Cole Kam sneakers, she opted to change things up this time with a pair of iconic black and white skate sneakers—Vans Canvas Old Skool. And her high-waisted cropped RE/DONE skinny jeans in all their reworked vintage glory complemented the throwback sneakers perfectly. She beat the heat in the form of her signature bralette and a marigold Topshop crop top.
Jenner is clearly aware that the ideal way to wear the most classic of denim styles is to pair them with equally classic sneakers. We love the idea of swapping out white sneakers for a darker color as fall approaches, and you can't go wrong with $55 Old Skools. At this point, it's safe to say that they'll never go out of style—they debuted in 1977. |
india
Updated: Jul 02, 2017 20:52 IST
Cow vigilantes allegedly stopped three vehicles transporting cattle with valid papers and assaulted the drivers near Guwahati on Sunday evening. Police, however, declined to confirm the assault.
Police in Sonapur, about 30km east of Guwahati, said they acted on a report that members of a local unit of the Hindu Yuba Chhatra Parishad stopped a truck and two three-wheelers carrying cattle.
Local TV channels showed the vigilantes thrashing the cattle transporters but police did not confirm the assault as “no one filed any complaint”.
“The drivers had proper papers for transporting the cattle but we found some irregularities in the permits of the vehicles,” said an officer of the Sonapur police station.
While the truck had come from eastern Assam’s Tinsukia, the three-wheelers were transporting the cattle locally.
Kamrup (Metro) district commissioner of police Hiren Nath said he was not aware of any group having attacked the cattle transporters. “The vehicles have been sent to the transport department for verification and to check if they were carrying more cattle than the number permitted,” he said.
A PTI report quoted a police official as saying that the Hindu Yuba Chhatra Parishad group was from Dimoria. The official said a police team was dispatched and it took control of the vehicles and the persons.
The official said the transporters had proper challans for transporting the cattle. The report added that the two tempos returned from the Jagiroad market.
“The drivers themselves drove the vehicles to the office of the District Transport Officer and nobody complained of any physical assault. No one has filed any complaint. We cannot confirm any assault,” the PTI report quoted the official as saying.
Guwahati police deputy commissioner (east) Mohneesh Mishra too declined to confirm the beating up of the drivers and helpers as no one filed any complaint with the police yet.
Asked if this was a case of cow vigilantism, Mishra said it was being examined.
(With PTI inputs) |
Your Processes,
Our Platform
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Work happens everywhere, and your processes shouldn’t be confined to a single application, let alone a single location. With Nintex Connectors, your processes can connect with various business applications and content repositories, on-premises or in the cloud, making it easier for users to access information, make decisions and act quickly.
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Nintex’s workflow platform works seamlessly with SharePoint and Office 365. It gives you the flexibility to be on-premises or in the cloud or benefit from a hybrid solution involving both. People can tackle assigned tasks from wherever they are, and the work flows automatically from place to place. |
[Phylogenetic analysis of 2009 H1N1 (A) influenza virus based on genomic sequence features].
From April 2009 onward, a new strain of human H1N1 influenza virus has swept over the world. The genome of influenza virus consists of 8 segments, encoding 10 proteins, respectively. The reassortments among the 8 segments cause the variation of influenza virus. Therefore, phylogenetic analysis of the 8 genes is very important. In this paper, we choose neighboring word frequency as the genomic features, using VC++ programming to analyze evolution of the 8 segments of H1N1 virus. As a result, we found that PB2 genes and PA genes of these three isolated virus were originated from North American avian influenza virus, that PB1 genes were originated from the seasonal influenza virus of human, and that HA genes, NS genes and NP genes came from the North American classical swine influenza A virus. The NA segments and M segments were originated from the European swine influenza virus. |
Q:
How to check the Year EDT lenght?
I created a Table's Field, and in addition to this, I created my custom EDT, named : MyEDT (for example).
MyEDT is INTEGER type and I have extended the System standard EDT YearBase.
So, if I insert the alphabetic characters (look like "abecjskjfh") I get an error.
But I need to have a rule, I want to insert only value with 4 Number character, I only want values look like : 2000 , 2006, 1982 etc... .
I can check/control this by code, in methods validateWrite or validateField I insered this code :
switch (p1)
{
case fieldNum(MyTable, MyField) :
if (strLen( (strFmt("%1",this.MyField)) ) != 4)
throw error ("Inser only value AAAA");
break;
}
But,It's possible or exist to creato or axtends the YEAR EDT with only 4 number char length ? Or, there is another way to check the length the field valu ?
Thanks all,
enjoy!
A:
If you want to use an integer EDT, I think there is no way to restrict the range of allowed numbers, except the AllowNegative property. So you have to do the validation in code like in your question. But I would suggest to change your validation logic to validate a number range instead of casting the number to a string and then validating the number of characters. This way you could also make sure that users cannot enter a year like 0000.
if (this.MyField< 1900 || this.MyField > 9999)
{
throw error("Please enter a year between 1900 and 9999");
}
Another possibility could be to use a date EDT where you set the DateYear, DateMonth and DateDay properties such that only the year is shown. This would also help with data entry (e.g. 2 gets replaced with 2002) and gives you a nice error dialog if the users enters for example "abc".
|
Just another WordPress.com site
Wayne Mouths off About How Big Corporate Can Lead Us To a More Sustainable Future
For three decades now I have been know as part of a design team that has been known as questioning, independent, and over the past decade or so, champions of social and sustainable thinking.
Over the last few years we have begun to work with large corporate organisations, not to feed turnover, but because it has become increasingly clear that because of the scale and investment available, bold initiatives can be undertaken.
The likes of Greenpeace and WWF (and the legions of small activists) have done wonderful jobs in hounding and naming and shaming corporations who have failed to take the environment, sustainability and ethical trading seriously. Their tireless campaigning has made a significant section of the public aware and helped to build a business environment where it makes business sense to “care”.
Whatever the tipping point has been, my overwhelming experience is of corporate who now hold sustainability, the environment and ethical thinking at their core. They have set up corporate responsibility departments and whole segments of the business who are dedicated to this thinking. They have employed directors who are zealous and “dedicated to the cause”, directors who have significant budgets at their disposal. They now have the economies of scale to really start to make a difference.
The work we are doing with McDonalds (in collaboration with up cycling and re use specialists Worn Again) in terms of working out a system that allows the uniforms of their 88,000 UK staff to eventually be able to be made into new material to make new uniforms ad infinitum is bold, industry leading and takes considerable investment.
We learnt a decade ago, when we started working with (Taylor) Wimpey Homes that sustainable projects of scale that resonate far and wide are much easier to deliver by collaborating with those that have most to gain (and to lose).
So it’s time for people to stop raising their eyebrows and look surprised that designers like us are choosing to work with the kind of corporations that the campaigning bodies that we support once hounded. Big Corporations are not The Devil incarnate they have an ability to lever their tremendous resources and some are now leading the way. |
National News
Cops Kill Man In Wal-Mart Carrying An Air Rifle That He Might Have Planned To Buy
A man who was carrying an air rifle in an Ohio Wal-Mart told the police officers that fatally shot him that the gun was “not real,” according to a family member.
John Crawford was shot by police Tuesday evening at a Beavercreek store. The Ohio attorney general’s office announced Thursday that he was merely carrying a brand of air rifle that Wal-Mart sells.
Another shopper, 37-year-old Angela Williams, collapsed and died as she scrambled to get away after police fired at Crawford.
The shooting occurred after police responded to 911 calls about a man carrying a rifle. In one of those calls, which was released by police, a Wal-Mart shopper told emergency dispatchers that it looked like the man — later identified as Crawford — was trying to load the rifle and that he had pointed it at two children, WHIO reported.
The 911 caller’s wife said that Crawford was on the phone and that he was messing with the gun. She said that after police ordered Crawford to put down the unidentified weapon, “I heard two shots after I saw him turn. He still had the weapon in his hand.”
But Crawford’s family says that there is no way he intended to harm anyone that night.
LeeCee Johnson, who has two children with Crawford and is pregnant with a third, said that she was on the phone with him while the incident unfolded. |
‘Real World: Ex-Plosion’ Poll: Was Ashley’s Outburst A One-Time Deal?
From the moment we met “Drunk Ashley,” we kiiiiinda had a feeling she might be one of the more…exciting members of the “Real World: Ex-Plosion” cast. However, what started in good fun turned horribly sour when the West Virginia native was accused of being an adulteress. Jamie — who is a self-proclaimed member of the cheat police — called Ashley out for messing around with two different guys that were not her boyfriend, and Ashley’s defense and subsequent outburst devolved into a house-wide fight. What followed was a waterfall of word vomit in which Ashley declared herself the best and richest person in the house, then ran down the street in a bikini threatening to defect. Woo! First night!
The morning after, Ashley claimed that it wasn’t like her to stir up so much drama or act out the way she did toward Cory and Jamie. The housemates were a bit perplexed when she downplayed her poor behavior, and even more so when she later pounced on Cory like a cat in heat. Even more bizarre: Cory, whose humble upbringing Ashley had been mocking less than 24 hours before, had no trouble welcoming her advances. And though Ashley didn’t get into another screaming match with anyone after her ill-advised burger toss, getting chastised for it left her in a mess of 100°-proof tears, as she couldn’t see what everyone was so upset about.
+ So, tell us what you think: Was Ashley’s first impression on the house just a fluke, or is she bound to stir up more drama? |
Workplace Stress – no longer a taboo!
Bob joined a multi-national corporate some 15 years ago and thoroughly enjoyed his role as a senior manager leading large teams. He performed exceptionally well in his job until 2012, when a number of major changes — divorce, a workplace restructuring and a new boss whom he seemed unable to please — came together and led to a period of physical ill-health, with sudden weight loss, migraine and severe stomach cramps among the more obvious symptoms.
What was less apparent to Bob’s colleagues and boss was the impact of undetected, unrelieved stress upon his mental health. Only two months after returning to work following a period of sick leave, Bob handed in his notice, exhausted and with shattered confidence as he realised that he no longer felt able to stay on top of his demanding role.
Bob is not his real name, but we all know someone like him. In 2012, the gravity and prevalence of unrecognised workplace stress was highlighted by reports indicating that hospital admissions for stress-related illness have sharply increased in recent years1. A Guardian report in October 2012 states that mental health issues are regularly ignored in the workplace, and account for some 140 million working days lost each year as a result of employee illness, at a cost of over £15 billion annually in lost revenue to the UK economy.
The report called for “a culture change right across the business sectors” with regard to managing employee mental health, underlining the enormous impact on human potential and organisational budgets when excessive pressure over a prolonged period leads to temporary mental incapacity, or worse, “breakdown”.
In the current economic climate of job cuts, reduced pay and high unemployment, it is not surprising that there should be renewed emphasis on the importance of stress management. Factors like these are way up the list of recognised stressors, alongside work overload, bullying and harassment.
But the destructive aspects of stress are nothing new. If your organisation takes stress seriously, employees may be fortunate to benefit from stress awareness training, mediation services, confidential on-site counselling, or a family-friendly, flexible-hours culture with opportunities for homeworking, adequate sickness and holiday leave, gym membership, career and redundancy-management support and coaching, among other possibilities.
If you work in or run an organisation that offers none of the above, that may be because of budget constraints — for smaller organisations struggling to stay in business, paying attention to the needs of overstretched employees may feel like an irrelevant luxury. Or, perhaps it is complacency — some well-funded major corporates still continue to neglect to offer employees support with stress-related difficulties, claiming that there is no perceived need.
Defining terms is an important starting point. Talent management theorists claim that stress at work is not only common, but is, to some extent, desirable. A temporary sense of challenge can and regularly does stimulate some employees to heightened performance, especially when support and encouragement is available to motivate people towards greater achievements.
Nonetheless, clear-cut distinctions exist between positive challenge and negative stress. The Health and Safety Executive (HSE) define stress as “the adverse reaction people have to excessive pressures or other types of demand placed on them at work”4. This emphasises the difference between pressure — the impact of circumstances — and stress, a human response that, while not in itself an illness, may lead to serious physical and mental illness when pressurising circumstances continue over a prolonged period — particularly when timely relief and support are not available.
The diseases that high levels of stress can cause range from severe immune depression causing repeated colds, coughs and flu, through stomach infections, heightened blood pressure and heart disease, to mental illness such as depression, panic attacks and, in the very worst cases, psychosis and even suicide.
This is the extreme, but timely, appropriate support can prevent ill-health, helping severely stressed people address the underlying issues that affect their well-being. Similarly, stress management support services can transform a return to work for a person on extended sick leave from a dreaded experience into a gradual, confidence-boosting recovery of their full capabilities.
But there are difficulties in detecting debilitating stress in colleagues. After all, there is no universal blueprint regarding how people react to pressurising circumstances. We have different levels of tolerance to ongoing stress, show that we are under pressure in different ways and employ varying strategies (some healthy, others less so) in order to cope. Similarly, and perhaps even more importantly, as human beings we vary enormously in our inclination and ability to talk effectively about our need for support in difficult times.
If you are aware that stress is something that needs addressing in your organisation or with you as a person then we have tools, techniques and experience that can help you start to address and manage this.
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Published by acornsupport
Do you have an employee who is not pulling their weight? Are there members of your team who are taking more time off sick than is reasonable? Are you concerned about the performance or behaviours of an employee? Be it a disciplinary, managing long term sick, handling a grievance or performance issue, Acorn Support will assist with ensuring the right actions are in place.
We seek to create partnerships with our clients to ensure that the services provided are flexible and tailored to meet the specific needs of the organisation.
We focus on the style and structure of each client's business on a one to one basis to ensure a personalised service is provided. We want to see a business achieve it's potential and are passionate about supporting and guiding our clients through the complexities of employment law and employment relationships.
Contact us if you want to take the headache out of employing people, the team at Acorn Support are here to help you - mail@acornsupport.co.uk, or 01562 881019
View all posts by acornsupport |
{-# LANGUAGE TypeApplications #-}
module Test.Spec.NewPayment (
spec
-- Public to be used by other testing modules.
, Fixture (..)
, withFixture
, withPayment
) where
import Universum
import Control.Lens (to)
import Test.Hspec (Spec, describe, shouldBe, shouldSatisfy)
import Test.Hspec.QuickCheck (prop)
import Test.QuickCheck (arbitrary, choose, withMaxSuccess)
import Test.QuickCheck.Monadic (PropertyM, monadicIO, pick)
import qualified Data.ByteString as B
import qualified Data.Map.Strict as M
import Data.Acid (update)
import Formatting (build, formatToString, sformat)
import Pos.Chain.Txp (TxOut (..), TxOutAux (..))
import Pos.Core (Address, Coin (..), IsBootstrapEraAddr (..),
deriveLvl2KeyPair, mkCoin)
import Pos.Core.NetworkMagic (NetworkMagic (..), makeNetworkMagic)
import Pos.Crypto (EncryptedSecretKey, ProtocolMagic,
ShouldCheckPassphrase (..), emptyPassphrase,
safeDeterministicKeyGen)
import Test.Spec.CoinSelection.Generators (InitialBalance (..),
Pay (..), genPayeeWithNM, genUtxoWithAtLeast)
import qualified Cardano.Wallet.API.V1.Types as V1
import qualified Cardano.Wallet.Kernel as Kernel
import Cardano.Wallet.Kernel.CoinSelection.FromGeneric
(CoinSelectionOptions (..), ExpenseRegulation (..),
InputGrouping (..), newOptions)
import Cardano.Wallet.Kernel.DB.AcidState
import Cardano.Wallet.Kernel.DB.HdWallet (AssuranceLevel (..),
HasSpendingPassword (..), HdAccountId (..),
HdAccountIx (..), HdAddressIx (..), HdRootId (..),
WalletName (..), eskToHdRootId, hdAccountIdIx)
import Cardano.Wallet.Kernel.DB.HdWallet.Create (initHdRoot)
import Cardano.Wallet.Kernel.DB.HdWallet.Derivation
(HardeningMode (..), deriveIndex)
import Cardano.Wallet.Kernel.DB.InDb (InDb (..))
import Cardano.Wallet.Kernel.Internal (ActiveWallet, PassiveWallet,
wallets)
import qualified Cardano.Wallet.Kernel.Keystore as Keystore
import qualified Cardano.Wallet.Kernel.NodeStateAdaptor as Node
import qualified Cardano.Wallet.Kernel.PrefilterTx as Kernel
import qualified Cardano.Wallet.Kernel.Transactions as Kernel
import Cardano.Wallet.Kernel.Types (AccountId (..), WalletId (..))
import qualified Cardano.Wallet.Kernel.Wallets as Kernel
import Cardano.Wallet.WalletLayer (ActiveWalletLayer)
import qualified Cardano.Wallet.WalletLayer as WalletLayer
import qualified Cardano.Wallet.WalletLayer.Kernel.Conv as Kernel.Conv
import qualified Test.Spec.Fixture as Fixture
import Util.Buildable (ShowThroughBuild (..))
import qualified Cardano.Wallet.API.V1.Handlers.Transactions as Handlers
import Control.Monad.Except (runExceptT)
import Servant.Server
{-# ANN module ("HLint: ignore Reduce duplication" :: Text) #-}
data Fixture = Fixture {
fixtureHdRootId :: HdRootId
, fixtureESK :: EncryptedSecretKey
, fixtureAccountId :: AccountId
, fixturePw :: PassiveWallet
, fixturePayees :: NonEmpty (Address, Coin)
}
-- | Prepare some fixtures using the 'PropertyM' context to prepare the data,
-- and execute the 'acid-state' update once the 'PassiveWallet' gets into
-- scope (after the bracket initialisation).
prepareFixtures :: NetworkMagic
-> InitialBalance
-> Pay
-> Fixture.GenActiveWalletFixture Fixture
prepareFixtures nm initialBalance toPay = do
let (_, esk) = safeDeterministicKeyGen (B.pack $ replicate 32 0x42) mempty
let newRootId = eskToHdRootId nm esk
newRoot <- initHdRoot <$> pure newRootId
<*> pure (WalletName "A wallet")
<*> pure NoSpendingPassword
<*> pure AssuranceLevelNormal
<*> (InDb <$> pick arbitrary)
newAccountId <- HdAccountId newRootId <$> deriveIndex (pick . choose) HdAccountIx HardDerivation
utxo <- pick (genUtxoWithAtLeast initialBalance)
-- Override all the addresses of the random Utxo with something meaningful,
-- i.e. with 'Address'(es) generated in a principled way, and not random.
utxo' <- foldlM (\acc (txIn, (TxOutAux (TxOut _ coin))) -> do
newIndex <- deriveIndex (pick . choose) HdAddressIx HardDerivation
let Just (addr, _) = deriveLvl2KeyPair nm
(IsBootstrapEraAddr True)
(ShouldCheckPassphrase True)
mempty
esk
(newAccountId ^. hdAccountIdIx . to getHdAccountIx)
(getHdAddressIx newIndex)
return $ M.insert txIn (TxOutAux (TxOut addr coin)) acc
) M.empty (M.toList utxo)
payees <- fmap (\(TxOut addr coin) -> (addr, coin)) <$> pick (genPayeeWithNM nm utxo toPay)
return $ \keystore aw -> do
liftIO $ Keystore.insert (WalletIdHdRnd newRootId) esk keystore
let pw = Kernel.walletPassive aw
let accounts = Kernel.prefilterUtxo nm newRootId esk utxo'
hdAccountId = Kernel.defaultHdAccountId newRootId
hdAddress = Kernel.defaultHdAddress nm esk emptyPassphrase newRootId
void $ liftIO $ update (pw ^. wallets) (CreateHdWallet newRoot hdAccountId hdAddress accounts)
return $ Fixture {
fixtureHdRootId = newRootId
, fixtureAccountId = AccountIdHdRnd newAccountId
, fixtureESK = esk
, fixturePw = pw
, fixturePayees = payees
}
withFixture :: MonadIO m
=> ProtocolMagic
-> InitialBalance
-> Pay
-> ( Keystore.Keystore
-> ActiveWalletLayer m
-> ActiveWallet
-> Fixture
-> IO a
)
-> PropertyM IO a
withFixture pm initialBalance toPay cc =
Fixture.withActiveWalletFixture pm (prepareFixtures nm initialBalance toPay) cc
where
nm = makeNetworkMagic pm
-- | A constant fee calculation.
constantFee :: Int -> NonEmpty Coin -> Coin
constantFee _ _ = mkCoin 10
-- | Helper function to facilitate payments via the Layer or Servant.
withPayment :: MonadIO n
=> ProtocolMagic
-> InitialBalance
-- ^ How big the wallet Utxo must be
-> Pay
-- ^ How big the payment must be
-> (ActiveWalletLayer n -> V1.Payment -> IO ())
-- ^ The action to run.
-> PropertyM IO ()
withPayment pm initialBalance toPay action = do
withFixture pm initialBalance toPay $ \keystore activeLayer _ Fixture{..} -> do
liftIO $ Keystore.insert (WalletIdHdRnd fixtureHdRootId) fixtureESK keystore
let (AccountIdHdRnd hdAccountId) = fixtureAccountId
let (HdRootId (InDb rootAddress)) = fixtureHdRootId
let sourceWallet = V1.WalletId (sformat build rootAddress)
let accountIndex = Kernel.Conv.toAccountId hdAccountId
let destinations =
fmap (\(addr, coin) -> V1.PaymentDistribution (V1.V1 addr) (V1.V1 coin)
) fixturePayees
let newPayment = V1.Payment {
pmtSource = V1.PaymentSource sourceWallet accountIndex
, pmtDestinations = destinations
, pmtGroupingPolicy = Nothing
, pmtSpendingPassword = Nothing
}
action activeLayer newPayment
spec :: Spec
spec = describe "NewPayment" $ do
describe "Generating a new payment (wallet layer)" $ do
prop "pay works (realSigner, SenderPaysFee)" $ withMaxSuccess 5 $ do
monadicIO $ do
pm <- pick arbitrary
withPayment pm (InitialADA 10000) (PayLovelace 10) $ \activeLayer newPayment -> do
res <- liftIO ((WalletLayer.pay activeLayer) mempty
IgnoreGrouping
SenderPaysFee
newPayment
)
liftIO ((bimap STB STB res) `shouldSatisfy` isRight)
describe "Generating a new payment (kernel)" $ do
prop "newTransaction works (real signer, SenderPaysFee)" $ withMaxSuccess 5 $ do
monadicIO $ do
pm <- pick arbitrary
withFixture @IO pm (InitialADA 10000) (PayLovelace 10) $ \_ _ aw Fixture{..} -> do
policy <- Node.getFeePolicy (Kernel.walletPassive aw ^. Kernel.walletNode)
let opts = (newOptions (Kernel.cardanoFee policy)) {
csoExpenseRegulation = SenderPaysFee
, csoInputGrouping = IgnoreGrouping
}
let (AccountIdHdRnd hdAccountId) = fixtureAccountId
res <- liftIO (Kernel.newTransaction aw
mempty
opts
hdAccountId
fixturePayees
)
liftIO ((bimap STB (const $ STB ()) res) `shouldSatisfy` isRight)
prop "newTransaction works (ReceiverPaysFee)" $ withMaxSuccess 5 $ do
monadicIO $ do
pm <- pick arbitrary
withFixture @IO pm (InitialADA 10000) (PayADA 1) $ \_ _ aw Fixture{..} -> do
policy <- Node.getFeePolicy (Kernel.walletPassive aw ^. Kernel.walletNode)
let opts = (newOptions (Kernel.cardanoFee policy)) {
csoExpenseRegulation = ReceiverPaysFee
, csoInputGrouping = IgnoreGrouping
}
let (AccountIdHdRnd hdAccountId) = fixtureAccountId
res <- liftIO (Kernel.newTransaction aw
mempty
opts
hdAccountId
fixturePayees
)
liftIO ((bimap STB (const $ STB ()) res) `shouldSatisfy` isRight)
describe "Generating a new payment (Servant)" $ do
prop "works as expected in the happy path scenario" $ withMaxSuccess 5 $
monadicIO $ do
pm <- pick arbitrary
withPayment pm (InitialADA 1000) (PayADA 1) $ \activeLayer newPayment -> do
res <- liftIO (runExceptT . runHandler' $ Handlers.newTransaction activeLayer newPayment)
liftIO ((bimap identity STB res) `shouldSatisfy` isRight)
describe "EstimateFees" $ do
describe "Estimating fees (wallet layer)" $ do
prop "estimating fees works (SenderPaysFee)" $ withMaxSuccess 5 $ do
monadicIO $ do
pm <- pick arbitrary
withPayment pm (InitialADA 10000) (PayLovelace 10) $ \activeLayer newPayment -> do
res <- liftIO ((WalletLayer.estimateFees activeLayer) IgnoreGrouping
SenderPaysFee
newPayment
)
case res of
Left e -> fail (formatToString build e)
Right fee ->
fee `shouldSatisfy` (> (Coin 0))
describe "Estimating fees (kernel)" $ do
prop "estimating fees works (SenderPaysFee)" $ withMaxSuccess 5 $
monadicIO $ do
pm <- pick arbitrary
withFixture @IO pm (InitialADA 10000) (PayADA 1) $ \_ _ aw Fixture{..} -> do
let opts = (newOptions constantFee) {
csoExpenseRegulation = SenderPaysFee
, csoInputGrouping = IgnoreGrouping
}
let (AccountIdHdRnd hdAccountId) = fixtureAccountId
res <- liftIO (Kernel.estimateFees aw
opts
hdAccountId
fixturePayees
)
case res of
Left e -> fail (formatToString build e)
Right x -> x `shouldBe` Coin 10
prop "estimating fees works (kernel, ReceiverPaysFee)" $ withMaxSuccess 5 $
monadicIO $ do
pm <- pick arbitrary
withFixture @IO pm (InitialADA 10000) (PayADA 1) $ \_ _ aw Fixture{..} -> do
let opts = (newOptions constantFee) {
csoExpenseRegulation = SenderPaysFee
, csoInputGrouping = IgnoreGrouping
}
let (AccountIdHdRnd hdAccountId) = fixtureAccountId
res <- liftIO (Kernel.estimateFees aw
opts
hdAccountId
fixturePayees
)
case res of
Left e -> fail (formatToString build e)
Right x -> x `shouldBe` Coin 10
prop "estimating fees works (kernel, SenderPaysFee, cardanoFee)" $ withMaxSuccess 5 $
monadicIO $ do
pm <- pick arbitrary
withFixture @IO pm (InitialADA 10000) (PayADA 1) $ \_ _ aw Fixture{..} -> do
policy <- Node.getFeePolicy (Kernel.walletPassive aw ^. Kernel.walletNode)
let opts = (newOptions (Kernel.cardanoFee policy)) {
csoExpenseRegulation = SenderPaysFee
, csoInputGrouping = IgnoreGrouping
}
let (AccountIdHdRnd hdAccountId) = fixtureAccountId
res <- liftIO (Kernel.estimateFees aw
opts
hdAccountId
fixturePayees
)
case res of
Left e -> fail (formatToString build e)
Right x -> x `shouldSatisfy` (> (Coin 0))
describe "Estimating fees (Servant)" $ do
prop "works as expected in the happy path scenario" $ withMaxSuccess 5 $
monadicIO $ do
pm <- pick arbitrary
withPayment pm (InitialADA 1000) (PayADA 1) $ \activeLayer newPayment -> do
res <- liftIO (runExceptT . runHandler' $ Handlers.estimateFees activeLayer newPayment)
liftIO ((bimap identity STB res) `shouldSatisfy` isRight)
-- The 'estimateFee' endpoint doesn't require a spendingPassword, but
-- the 'Payment' type does come with an optional 'spendingPassword' field.
-- Here we want to check this is completely ignored.
prop "ignores completely the spending password in Payment" $ withMaxSuccess 5 $
monadicIO $ do
randomPass <- pick arbitrary
pm <- pick arbitrary
withPayment pm (InitialADA 1000) (PayADA 1) $ \activeLayer newPayment -> do
-- mangle the spending password to be something arbitrary, check
-- that this doesn't hinder our ability to estimate fees.
let pmt = newPayment { V1.pmtSpendingPassword = randomPass }
res <- liftIO (runExceptT . runHandler' $ Handlers.estimateFees activeLayer pmt)
liftIO ((bimap identity STB res) `shouldSatisfy` isRight)
|
The problem was that the reprocessed files from IUCr, although weremore complete, "resurrected" data errors that were corrected in theprevious recisions. The additional data that have been extractedduring the reprocessing will have to be merged without overwriting theexisting values in COD files, except some explicit and controlledcases (such as publication titles and chemical names).
cif/Commiting CIFs, that were updated with the 'cif_fix_values' script, using options '--fix-misspelled replacement_values.lst', '--fix-temperature' and '--fix-enums' with built-in table of enum values.
cod/cif/Changing all _chemical_formula_sum values, were necessary, to conformIUCr recommended syntax and sorting order. After this operation, itwill be easier to search for structures using the_chemical_formula_sum values.
Only those files and thos lines that really needed to be changed werechanged; otehrwise the CIFs were not reformatted.
The procedure was as follows:
first, all files were passed through a 'cif_filter--parse-formula-sum' command, and the lines containing_cif_formula_sum matching tags were extracted. The extracted tags were"spliced" into the CIF files using the ./bin/{un,}grepciftag commandsand awk to filter out old tags and add new tags in their place; thereplacement was only done if the new tags contained "_cod_" tags('grep -q _cod_ tmp-$$'), indicating that cif_filter has altered theformula, or the original file did not contain the_chemical_formula_sum tag ('! grep -q _chemical_formula_sum X'),indicating that cif_filter has guessed the chemical_formula_sum fromthe file (which should not have happened, actually). If the file wasdifferent, disregarding spaces, from the original one ('if ! diff -wbX tmp2-$$'), the original was replaced by the new file, to becommitted to the repository. |
Q:
Images uploaded into ActionText text area not linking correctly to S3
I am using ActionText with image upload using the image_processing gem. However, when uploading images they do not go to S3 which is set in Active Storage.
All other image uploads work fine and go into my S3 buckets as expected. It is just images uploaded into the ActionText editor that does not use the S3 URL. They do go into the correct buckets, however. It is just the URL that I can't change or get access to in the blob element.
I assume there is a setting in an initializer or config that I have not been able to find but I can't find it through the documentation or google.
The URL the blob is currently using is the rail/active_storage/ storage URL and I need it to use the S3 URL I have set in the active_storage.yml file.
A:
Turns out I could edit the URL in the _blob.html.erb file. First I had to check if I was in Production or not. Once I verify that I was able to construct the URL to grab from S3 using the blob.key.
<% if blob.representable? %>
<% if Rails.env == 'production' %>
<img class: "post-actiontext-image" src="https://<%= ENV['S3_BUCKET'] %>.s3-<%= ENV['AWS_REGION'] %>.amazonaws.com/<%= blob.key %>" />
<% else %>
<%= image_tag blob.representation(resize_to_limit: local_assigns[:in_gallery] ? [ 800, 600 ] : [ 1024, 768 ]), class: "post-actiontext-image" %>
<% end %>
<% end %>
|
A Qualitative Study Investigating the Continued Adoption of Breaking Free Online Across a National Substance Misuse Organisation: Theoretical Conceptualisation of Staff Perceptions.
There is evidence for the effectiveness of computer-assisted therapies (CAT) in healthcare; however, implementing CAT can be challenging due to new technologies being perceived as 'disruptive'. This study used normalisation process theory (NPT) to investigate how Breaking Free Online (BFO), a treatment programme for substance misuse, is embedded as normal practice within Crime Reduction Initiatives (CRI), a health and social care charity. Interviews were conducted with CRI staff regarding their perceptions of the normalisation of BFO. Thematic analyses were used and findings structured around NPT. Results suggest that staff understood the benefits of BFO, particularly for those with a dual diagnosis. However, there was some confusion surrounding job roles and difficulties with the availability of resources. Whilst normalisation of BFO is progressing within CRI, there are still some challenges. Clarification of the roles of staff and peer mentors is an area in which further work is being conducted. |
/*
* Copyright (C) 2015 Red Hat, Inc. and/or its affiliates.
*
* Licensed under the Apache License, Version 2.0 (the "License");
* you may not use this file except in compliance with the License.
* You may obtain a copy of the License at
*
* http://www.apache.org/licenses/LICENSE-2.0
*
* Unless required by applicable law or agreed to in writing, software
* distributed under the License is distributed on an "AS IS" BASIS,
* WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
* See the License for the specific language governing permissions and
* limitations under the License.
*/
package org.jboss.errai.ioc.client.lifecycle.api;
public interface LifecycleListenerRegistrar {
public <T> Iterable<LifecycleListener<T>> getListeners(Class<? extends LifecycleEvent<T>> eventType, T instance);
public <T> void registerGenerator(Class<T> lifecycleType, LifecycleListenerGenerator<T> generator);
public <T> void registerListener(T instance, LifecycleListener<T> listener);
public <T> void unregisterGenerator(Class<T> lifecycleType, LifecycleListenerGenerator<T> generator);
public <T> void unregisterListener(T instance, LifecycleListener<T> listener);
public <T> boolean endInstanceLifecycle(T instance);
}
|
Q:
Spring Hibernate Query could not resolve property
One staff reports to one reporting officer, and one reporting officer can have multiple staffs.
With that said, I have self-mapped them together in Staff.java
//reporting officer
@ManyToOne (cascade = {CascadeType.MERGE, CascadeType.DETACH, CascadeType.REFRESH})
@JoinColumn(name = "reporting_officer_id")
private Staff reportingOfficer;
And in my database
CREATE TABLE `tbl_staff` (
`id` INT NOT NULL AUTO_INCREMENT,
`staff_no` INT(5) NOT NULL,
`staff_name` VARCHAR(25) NOT NULL,
`login_id` VARCHAR(16) NOT NULL,
`date_of_birth` DATE NULL DEFAULT NULL,
`joined_date` DATE NULL DEFAULT NULL,
`department_id` INT NULL DEFAULT NULL,
`designation` VARCHAR(255) NULL DEFAULT NULL,
`reporting_officer_id` INT NULL DEFAULT NULL,
`photograph` BLOB NULL DEFAULT NULL,
FOREIGN KEY (`department_id`) REFERENCES tbl_department(`id`),
PRIMARY KEY (`id`)
);
I'm trying to perform this query...
@Query("FROM Staff t WHERE " + "t.reporting_officer_id=:reportingOfficerId")
public List<Staff> findStaffsWithSameReportingOfficer(@Param("reportingOfficerId") int reportingOfficerId);
And I'm getting this error...
Caused by: org.hibernate.QueryException: could not resolve property: reporting_officer_id of: com.staff.domain.Staff [FROM com.staff.domain.Staff t WHERE t.reporting_officer_id=1]
at org.hibernate.QueryException.generateQueryException(QueryException.java:120)
at org.hibernate.QueryException.wrapWithQueryString(QueryException.java:103)
at org.hibernate.hql.internal.ast.QueryTranslatorImpl.doCompile(QueryTranslatorImpl.java:217)
at org.hibernate.hql.internal.ast.QueryTranslatorImpl.compile(QueryTranslatorImpl.java:141)
at org.hibernate.engine.query.spi.HQLQueryPlan.<init>(HQLQueryPlan.java:115)
at org.hibernate.engine.query.spi.HQLQueryPlan.<init>(HQLQueryPlan.java:77)
at org.hibernate.engine.query.spi.QueryPlanCache.getHQLQueryPlan(QueryPlanCache.java:153)
at org.hibernate.internal.AbstractSharedSessionContract.getQueryPlan(AbstractSharedSessionContract.java:545)
at org.hibernate.internal.AbstractSharedSessionContract.createQuery(AbstractSharedSessionContract.java:654)
... 124 common frames omitted
Caused by: org.hibernate.QueryException: could not resolve property: reporting_officer_id of: com.staff.domain.Staff
at org.hibernate.persister.entity.AbstractPropertyMapping.propertyException(AbstractPropertyMapping.java:62)
at org.hibernate.persister.entity.AbstractPropertyMapping.toType(AbstractPropertyMapping.java:56)
at org.hibernate.persister.entity.AbstractEntityPersister.toType(AbstractEntityPersister.java:1859)
at org.hibernate.hql.internal.ast.tree.FromElementType.getPropertyType(FromElementType.java:393)
at org.hibernate.hql.internal.ast.tree.FromElement.getPropertyType(FromElement.java:512)
at org.hibernate.hql.internal.ast.tree.DotNode.getDataType(DotNode.java:660)
at org.hibernate.hql.internal.ast.tree.DotNode.prepareLhs(DotNode.java:264)
at org.hibernate.hql.internal.ast.tree.DotNode.resolve(DotNode.java:204)
at org.hibernate.hql.internal.ast.tree.FromReferenceNode.resolve(FromReferenceNode.java:109)
at org.hibernate.hql.internal.ast.tree.FromReferenceNode.resolve(FromReferenceNode.java:104)
at org.hibernate.hql.internal.ast.HqlSqlWalker.resolve(HqlSqlWalker.java:1033)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.expr(HqlSqlBaseWalker.java:1286)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.exprOrSubquery(HqlSqlBaseWalker.java:4699)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.comparisonExpr(HqlSqlBaseWalker.java:4169)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.logicalExpr(HqlSqlBaseWalker.java:2134)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.whereClause(HqlSqlBaseWalker.java:813)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.query(HqlSqlBaseWalker.java:607)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.selectStatement(HqlSqlBaseWalker.java:311)
at org.hibernate.hql.internal.antlr.HqlSqlBaseWalker.statement(HqlSqlBaseWalker.java:259)
at org.hibernate.hql.internal.ast.QueryTranslatorImpl.analyze(QueryTranslatorImpl.java:261)
at org.hibernate.hql.internal.ast.QueryTranslatorImpl.doCom
A:
@Query("SELECT t FROM Staff t WHERE t.reportingOfficer.id = :reportingOfficerId")
public List<Staff> findStaffsWithSameReportingOfficer(@Param("reportingOfficerId") Integer reportingOfficerId);
|
Tuesday, March 14, 2006
Bob Towner's Reflections -- Part III
This chronicles the first part of the journey
Landing in Nairobi, Kenya, after 40 hours of travel, we will overnight before heading to the Sudanese interior. The Bishop greets us and shuffles us into small cars. Police checkpoints dot the airport entry and stop us. Did we catch a cab at the airport? My travel mate says “Yes,” and our driver is interrogated for several minutes. He has no cab license, he is a church employee. We resume our night journey. We pass a large fancy building. It is the abandoned U. S. Embassy. They have rebuilt far from the airport. We are in Africa now. It occurs to me, that this is all disputed territory. As modernity dawns on Africa, the world wants to know, who will control, exploit, and manage the population, the territory and the resources? Will anyone come to Africa to give and not to take?
I get to know our driver, Ngumbai, at breakfast. I ask, “When did you become a Christian?” His village was destroyed by bombs, then fire in the civil war. His family was driven into the bush. Mother and father and siblings were killed when he was 13 years old. He was left alone, crying himself to sleep under the stars, about being without home, “without a daddy.” One night in a dream, he hears, “You do have a father, the One whom Jesus calls Father.” When he awoke he was surrounded by supernatural light, which he took as confirmation of the dream’s truth. The next day, he found a friend and told him the dream and his conviction that they could follow Jesus to this Father, just as Matthew and James and John and all of them had, leaving all behind and following Jesus to the Father. Ngumbai and his friend set out into the bush with no guide but signs in the sky. He crossed over into Uganda, and eventually into Kenya, “with no passport,” he said, “except the cross.” In Nairobi, the center of Kenya, he was led to the exiled Moru Christian community, where he began a radically new life. I realize we are going to meet his new extended family.
A small, one engine bush plane awaits us at the regional airport. Six of us will ride with a portable gas powered generator, boxes of books, bottled water, clothes and medical supplies donated by churches. Our pilot is Dan, flying for AIM, which is in business to drop off missionaries and supplies to African villages. We buckle up and he says, “Let’s pray.” I don’t know whether to laugh or cry. I assure myself:”but of course, I always pray before take off and landing.”
We fly along the ridges of the Great Rift Valley. What I can see below reminds me of Wyoming. But it is dry season, and I am told it all greens up when it rains, if it rains. Somewhere in here are the headwaters of the Nile River, the life line for everything north of this place.
Two and a half hours later we land in Loki, on the Kenyan side of the Sudan’s southern border. This is our last cold drink and flush toilet for a while. Loki is a sprawling town, a village which has grown up around this drop off point for international aid. I count a half dozen U. N. planes. They don’t want us taking photos. Pilots out of Loki are rumored to file bogus flight plans and then heading into dangerous or prohibited regions to make their food and medicine drops.
Two more hours into Sudan. From 12,000 feet I am looking at wilderness., only a few trees dotting a rosy, sand colored landscape. But as we descend, I begin to see life, well camouflaged mud houses with thatched roofs made of bundled tall grass. We touch down on a nice flat dirt runway and step out into 100 degree sun. Two vehicles, one from our hospital and one from our cathedral meet us. Sixteen miles to go to the town of Lui, our mission base.
I get my first close look at the African savannah. It’s baked from drought and the dry season. Less than a half hour on the ground and I am thirsty. We pass a clearing on the left. That is going to be the new Anglican Trinity Bible College. My roommate, Rick, is going to be asked to help build it. I will be asked to help teach in it. I realize, I have just been promoted, we all have, due to the privileges of our education, our training and the resources we have at our disposal. These, Ngumbai’s new family, are also our new family, we are long, lost cousins. But our people brought their people a Word of hope to the Moru in the 1920’s, and these folks need it more than ever now, as they emerge from decades of civil war. Now I am praying really hard....
2 comments:
I'm reading this because of my interest in Lui, yet I find myself especially taken with the question of whether bringing education and healthcare would work in Missouri as it did in 19th-century Africa. Makes me think of the MDGs and what have I done so far beyond giving a little money?
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Lui, Sudan
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About Me
I'm a progressive Episcopalian raised in the South and now (thanks to a job change) living in the conservative Midwest. I worship at Grace Episcopal Church in Jefferson City. I love the Episcopal Church, which rescued me from a life of wandering meaningless and gave me a way to explore my faith and belief in God.
On any given topic, I am prone to yammer-on way too long. Sometimes I ponder way more than I should.
A blog-friend said that I demonstrate a "muscled love for our Church." I hope I can live up to that.
And right now I'm pondering Blogger's challenge to define myself in 1200 characters. |
Title:Sim-Game based Training System for Scene and Patient Management Following Blast Injury from Explosives Including Improvised Explosive Device (IED)
Agency / Branch:DOD / OSD
Contract:W81XWH-09-C-0044
Award Amount:$99,999.00
Abstract:
Though members of the military have long been susceptible as victims of injuries from explosions; this has become increasingly prevalent with the employment of improvised explosive devices (IEDs) in Iraq and elsewhere. Combat medical personnel and their civilian counterparts must be trained to recognize and understand the mechanism of injury from explosives and provide proper assessment, care and evacuation to survivors. In most blast circumstances a mass casualty situation will result. This will likely require an effective and accurate patient triage to accomplish the principle of achieving the greatest good for the greatest number. Triage procedures are relatively simple to apply, however they are most difficult for first responders to employ. This project develops and demonstrates a prototype sim-game based training adjunct for Combat Medics with current emergency medical technician (EMT) and advanced skills training. |
Users typically use a client, e.g., a browser, to access software applications over the Internet. The client provides a graphical user interface (GUI) to enable a user to access content from and navigate within the software applications. Current client GUIs only implement graphical elements that provide page-based navigation within and between the software applications. But this page-based navigation is inefficient because it requires the user to click through multiple pages to view desired content. Not only does this page-based navigation require the client to repeatedly open and close pages—which degrades user experience, but also it increases the number of queries and requests sent to a server hosting the software applications. These queries and requests increase the server's load, hog the server's processing bandwidth, and further degrade a responsiveness of the software applications.
In the drawings, like reference numbers generally indicate identical or similar elements. Additionally, generally, the left-most digit(s) of a reference number identifies the drawing in which the reference number first appears. |
Dezmine Wells is a big, fast, strong college basketball player -- a 6-foot-4 guard built like a prototypical linebacker, who plays the game like one, too. He was a top-50 recruit who only scratched the surface of his potential in his first season at Xavier, but averaged nearly 10 points and five rebounds a game (along with a 108.1 offensive rating and 37 percent from beyond the arc) in a largely tumultuous year.
After a prosecutor and grand jury's forceful rebuttal of Xavier's decision to expel Wells, his services would have been warmly welcomed by any of the nation's best teams, including the defending national champion Kentucky Wildcats, which hosted Wells last week.
Instead, Wells, as he announced via what appears to be the iPhone Notes app at 10 a.m. ET Tuesday morning, chose rebuilding Maryland:
"The last couple of weeks have been the toughest in my life for my family and I," Wells' announcement read. "I've learned that it is a major responsibility that comes with being a student-athlete at all times. I'm thankful God has blessed me with a second opportunity to continue my education. I would like to thank UK, UM, UMD and UO for their recruitment and interest in me as a student-athlete. After careful consideration with my family, I've decided to attend the University of Maryland."
Those school acronyms are a little confusing, but that's why we're here: Wells chose Maryland over Kentucky, Memphis and Oregon. The decision came after a little more than a week's worth of predictable and understandable recruiting efforts. As bonus talents go -- as players who drop in your lap and immediately improve your program's short-term outlook -- Wells is a keeper, a rare opportunity to land a proven college player with a ready body in the final week of August.
Xavier's strange decision made Wells the most desirable free agent in recent transfer history. Of course a solid collection of schools went after him. That was hardly a surprise.
What was surprising was Wells' decision. Maryland coach Mark Turgeon toppled two recruiting powerhouses -- Kentucky and Memphis -- and an Oregon program with some of the best facilities in the country (and oodles of playing time to boot). Wells won't pay immediate dividends (he'll almost certainly have to sit out the customary transfer year, barring any sort of precedent-setting hardship transfer waiver ruling by the NCAA).
But he sets the Terps up for a rather massive 2013-14 season. Turgeon is inserting two top-100 players into his lineup in 2012 -- top-10 center Shaquille Cleare and top-20 small forward Jake Layman. He's bringing back a batch of promising young players, including sophomores Nick Faust and Alex Len. And that's before Turgeon, who has massively expanded Maryland's recruiting footprint since taking the job last summer, truly shores up his 2013 class. (Could the Harrison twins be next?)
Taken as a whole, Wells' decision essentially gives Maryland the equivalent of a top-20 recruit -- if not better -- for the 2013-14 season. Combined with the rest of Turgeon's assets, and the players he can go out and get now, it now seems certain that by Year 3 the new Maryland head coach will be able to showcase serious progress toward the program's goal of returning to the national elite.
There was nothing textbook about Wells' arrival, but when a 6-foot-4 ready-made beast of a college baller lands in your lap, you don't question the fates. You just keep moving forward. |
Market Update – First Quarter 2017
What a difference a year makes! If you have a good long memory, you may recall that the S&P 500 began 2016 with its worst start ever. This time around volatility was much more subdued. Instead of hitting new multi-year lows, as we did in February 2016, we have been regularly hitting new all-time highs.
The first quarter of 2017 provided the highest returns for US large-cap stocks since 2013. The S&P 500 index was up 5.5%, while small cap stocks, which had a stellar year in 2016 (where they delivered returns over 22%) posted a relatively modest 2.2% gain.
Even international investments did well through the start of the year. Finally! The broad-based EAFE index of companies in developed foreign economies gained 6.5%, while emerging market stocks of less developed countries led all asset classes by, rising 11.2%.
Real estate investments, as measured by the Wilshire US REIT index, eked out a 0.03% gain during the quarter. Commodities overall lost 2.5%, which is in part due to a 5.8% drop in oil prices. On the other hand, gold prices shot up 8.6% during the period. Go figure.
In the bond markets, interest rates continued their incremental rise from practically zero to not much more than zero. Bond returns were muted during the quarter, hovering around 1%.
Overall it was a positive experience for investors—smooth sailing, as they say. Stocks continued the rally that started after the presidential election, responding positively to the pro-business agenda coming from the new administration. However, the new administration has been learning the hard way just how difficult it is to get things done in Washington, even when your party controls both houses and the presidency.
The recent healthcare bill setback seemed to temper the markets’ animal instincts and caused it to sell off slightly as the quarter drew to a close. If President Trump’s other policy goals receive similar “cold shoulder” treatment in Congress, particularly his tax, budget, and infrastructure policies, we could very well see a further pause or even a partial reversal of the “Trump Rally” in stocks that we’ve seen since he was elected.
Another looming concern for investment markets has been whether the new administration will act on some of the trade threats that were made during the presidential campaign. A trade conflict with one or more of our major trading partners like Mexico or China may not be viewed favorably by investors. However, in recent months, it appears the rhetoric has toned down, with the Trump administration indicating it will seek only modest changes to trade agreements like NAFTA. Also, the tough talk on China might just be that—talk. It’s no secret that both the US and China depend on each other economically, and upsetting that relationship is not in the best interest of either country.
The future of interest rates will remain on investors’ minds throughout 2017 and into next year. The Federal Reserve seems poised to raise the fed funds rate a couple more times before the end of the year, and Fed officials appear to be going out of their way to telegraph their plans to avoid market surprises. As we have said before, the fact the Fed feels comfortable normalizing rates is a GOOD thing for the economy and investment markets. It means they feel confident that the economy can support higher rates. This does not mean that there won’t be hiccups along the way, but it should not disrupt the continued expansion of the US and global economy.
While a lot of the recent “Trump rally” is riding on pro-business policies, it isn’t as though the rally is otherwise built on sand. There are other positive economic developments around the world that support stock prices.
US corporate profits, which had stalled out for the last 18 months or so, have started rising again. They increased at an annual rate of 2.3% in the fourth quarter. This is what really matters for future stock prices. It can be easy to get caught up in the political events of the day, with the headlines coming at us from every direction. What is important to remember is that while political headlines may influence markets day-to-day, in the long run the main driver of stock market returns are always corporate profits. As you can see from the chart below, corporate profits and stock market returns are highly correlated with one another.
The question long-term investors need to ask themselves is, “are corporate profits continuing to expand?” Said another way, are the great companies in America and the world going to continue to grow and make money? If so, there is no reason the stock market shouldn’t follow that trend line. Politics and anxiety may dominate today’s headlines, but for long-term investors this is all that really matters.
Another positive improvement for stocks is that parts of Europe and developing economies are finally starting to show signs of growth. Many of these economies have suffered years with little to no economic growth, dampening the pace of global economic recovery. Another encouraging sign is consumer confidence, as measured by the Conference Board’s Consumer Confidence Index, surged to the highest level since 2000. High levels of confidence tend to be associated with better than average growth.
After the robust market performance over the past four months, it wouldn’t be surprising if we experienced some sort of short term pullback. If that happens, it doesn’t mean we need to start worrying. Periodic adjustments are actually signs of a healthy market.
There are any number of events that could temporarily disrupt the current bull market trend. We can never predict what those events will be, or when they will occur. The assumption that periodic and temporary declines will naturally occur from time to time is already built into your beautifully diversified portfolio. We will continue to keep our finger on the pulse or the markets and global economy, always looking for opportunities to take advantage of investment opportunities when they present themselves.
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Rankings and/or recognition by unaffiliated rating services and/or publications should not be construed by a client or prospective client as a guarantee that he/she will experience a certain level of results if Del Monte is engaged, or continues to be engaged, to provide investment advisory services, nor should it be construed as a current or past endorsement of Del Monte by any of its clients. Rankings published by magazines, and others, generally base their selections exclusively on information prepared and/or submitted by the recognized adviser.
Each client and prospective client agrees, as a condition precedent to his/her/its access to Del Monte’s web site, to release and hold harmless Del Monte, its officers, directors, owners, employees and agents from any and all adverse consequences resulting from any of his/her/its actions and/or omissions which are independent of his/her/its receipt of personalized individual advice from Del Monte. |
Biomass, lipid productivities and fatty acids composition of marine Nannochloropsis gaditana cultured in desalination concentrate.
In this study the feasibility of growing marine Nannochloropsis gaditana in desalination concentrate (DC) was explored and the influence of the DC concentration on the biomass growth, lipid productivities and fatty acids composition was assessed. The reuse of the medium with the optimum DC concentration in successive algal cultivation cycles and the additional of a carbon source to the optimized medium were also evaluated. On varying the DC concentration, the maximum biomass concentration (0.96gL(-1)) and lipid content (12.6%) were obtained for N. gaditana in the medium with the optimum DC concentration (75%). Over the course of the reuse of the optimum DC medium, three cultivation cycles were performed, observing that the biomass productivity is directly correlated to lipid productivity. Palmitic acid was the major fatty acid found in N. gaditana cells. The saturated fatty acids content of the algae enhanced significantly on increasing the DC concentration. |
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We will also waive your leasing fee when your house is rented. This will save you up to $2,000.
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After the three years is up you can continue to rent your home through Westhill or we can sell it for you.
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Complete anOnline Enrolment Form or submit a completed Enrolment Form directly to reception at one of the campuses or via mail to:
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Q:
Movie where a boy is transported into the future by an alien spaceship
I am attempting to find the title of a live action (not animated) movie I once watched on a VHS tape years ago, sometime around 2000-ish, although I believe that the movie had existed long before I watched it. I believe that it was in color (it was not black and white); however, I am not 100% sure this is true. The main plot followed a young boy in America who was transported years into the future by a friendly alien spaceship. I can remember that this boy doesn't remember that he traveled through time, and he attempts to go back home, where he finds that his house has a different family living in it (because he was in the future). The boy eventually finds his family, but they are years older and have been looking for the him since the night he was taken through time.
I can also remember that the U.S. government eventually got involved and kept the boy in confinement to try and discover why he didn't age, but that's about all I can remember. In the end, the boy does end up getting transported back to his own time; however, I do not recall how this happened.
I hope that this is not too vague - if anyone has any ideas as to what this film is called I would be very appreciative to hear them.
A:
This is Disney's 1986 film, The Flight of the Navigator
On the night of July 4, 1978, in Fort Lauderdale, Florida, 12-year-old David Freeman walks through the woods to pick up his 8-year-old younger brother, Jeff, from a friend's house when he accidentally falls into a ravine and is knocked unconscious. When he comes to, he discovers that eight years have passed and it is now 1986. Police are shocked to see David fits exactly the same photo on a missing child poster, not having aged at all. David is reunited with his aged parents and Jeff is now 16. Meanwhile, an alien spaceship crashes through power lines and is promptly captured by NASA. David is taken to the hospital for tests where his brainwaves reveal images of the spaceship. Dr. Louis Faraday, who has been studying it since its arrival, persuades David to come to a NASA research facility for just 48 hours for extra tests, promising him that they can help him learn the truth about what happened to him. There, Dr. Faraday discovers that David's mind is filled with alien technical manuals and star charts covering expanses of the galaxy far exceeding NASA's research. It tells the scientists that he was taken to a planet called Phaelon, 560 light years away, in just over 2.2 hours. They realize that he has experienced severe time dilation as a result of having traveled faster than the speed of light, explaining why eight years have passed on Earth, but not for him. He is unable to comprehend what Dr. Faraday tells him and flees the room, leaving Dr. Faraday muttering that 48 hours will be insufficient to finish his investigation.
The next morning, following a telepathic communication from the spaceship, David secretly boards it and meets its robotic commander, "Trimaxion Drone Ship" (or "Max" for short), which refers to David as the "Navigator". After they escape from the facility, Max tells David that his mission was to travel across the galaxy, collect biological specimens, take them to Phaelon for analysis, and then return them to their homes. Phaelon's scientists discovered humans only use 10% of their brain and, as an experiment, filled the remainder of David's with miscellaneous information. This includes all of the star charts discovered by Phaelon's astronomers, some of which were shown to the NASA scientists during David's interrogation. Max then returned him to Earth, but did not take him back to his own time, having determined that a human would be unlikely to survive a trip back in time. Before leaving Earth, Max accidentally crashed the spaceship, erasing all the computer's star charts and data. Therefore, he needs the information in David's brain to return home....
Trailer
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Six-year report of the periodontal health of fixed and removable partial denture abutment teeth.
There were minimal differences in longitudinal periodontal effects when fixed and removable partial dentures were compared. Both treatment alternatives provide long-term periodontal health and should be considered for the restoration of a partially edentulous arch. Regardless of treatment, conscientious home care and professional prophylaxis are recommended. |
[Drugs that modulate the cellular function of calcium ion].
Cytoplasmic Ca(2+) concentration is kept low level of about 10(-7)M. When Ca(2+) concentration increases by specific stimuli via opening of channel proteins, Ca(2+) binds to Ca(2+)-binding proteins, activating specific proteins, results in responding the stimuli. In this report, we summarize the effect of drugs, of which targets are the proteins above, including Ca(2+)-pump, ion exchanger, ion channels, calmodulin and calmodulin-binding proteins, and other Ca(2+) binding proteins. |
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Saturday, August 21, 2010
Great Finds: Where should I start?
A week ago I went with my wife, my friend Bobby of the Video Game View and his girlfriend and we went to the beach. While we where at the beach we went to a used game store called Player’s Choice. We were able to visit 2 different locations, one in Whiteville and one in Shallotte. I was able to clean up on games that I wanted at these stores. With games at great prices who could argue. These stores were awesome. I was able to get games like Dragon Warrior III for NES, Star Fox for SNES, Metroid II: Return of Samus for Game Boy, Super Mario 64 for N64 and Star Wars: Episode 1: Jedi Power Battles for PS1. I also ventured into a random thrift shop while on vacation and they had a complete copy of Eternal Champion for the Sega Genesis for only $3 in great shape. Those were a few of the games I purchased but it didn’t stop there. On my way back home I stopped by the store Ed McKay in Winston-Salem. I picked up Final Fantasy for the NES with the box for $12. It didn’t have the instruction booklet but the box and game looked like they were untouched. I also picked up Donkey Kong for the Game Boy and I picked up Mega Man X4 for the PS1 for only $2. I also picked up a used player’s handbook for Dungeons and Dragons for half the retail value. It didn’t stop there either, the next day I came across Castlevania: Aria of Sorrow for Game Boy Advance. Over all I found so many games I want to thank my lovely wife for buying me Dragon Warrior 3 which cost $30. It was my birthday gift. Some would say $30 is kind of steep for a Nintendo game but that game alone on eBay goes for between $40 and $50. Over all I pick up 23 games and 1 book (about a game). Here is a picture and a list of all the games I got:
I was so happy to get to go to these game stores while I was on vacation. Holden Beach will probably be a regular vacation spot for me and my wife and our friends not just for the games but the Beach is pretty awesome and sometimes taking a break from games is a good thing. Well the vacation is over now so back to gaming. |
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Preventative Skin Cancer Methods For Your Nose
At San Francisco Center for Facial Plastic, Reconstructive & Laser Surgery, we offer reconstructive surgery after Mohs micrographic surgery. This is a surgical technique used to treat skin cancer in sensitive areas, such as the face and nose. Here is a picture of a common type of cancer on the nose called Basal Cell Carcinoma.
Specialized dermatologic surgeons who limit their practice to treating skin cancer patients perform this surgery. After the cancer removal, Dr. Ransom has extensive experience in the reconstruction of the resulting effects of the Mohs procedure.
It’s important to remember that protecting your nose from the harmful rays of the sun can help prevent skin cancer. Here are a few ways you can combat those rays and prevent skin cancer on your face.
No matter how big or small your nose is, it always protrudes out further from the rest of your face and is more susceptible to receiving the sun’s harsh rays. A sun hat with a brim that is at least 3 inches wide would protect your nose and the rest of your face from sunburn. Choose an under-brim that is darker in color. These brims absorb more of the UV rays that are reflected up to your face by water, snow and sand.
The sun is the brightest between 10 a.m. and 3 p.m. Try avoiding your nose to sun at this time. If you must be outside at this time, always seek out shade.
Always apply at least 30 SPF to you entire face. You can apply opaque zinc oxide to your nose for an additional measure of protection. |
Introduction
============
Copy number variations of the 15q11.2 region of the human genome are implicated in the development of neurological and neuropsychiatric conditions such as autism spectrum disorder (ASD), epilepsy, intellectual disability (ID) and schizophrenia (SCZ).^[@bib1],\ [@bib2],\ [@bib3],\ [@bib4],\ [@bib5],\ [@bib6],\ [@bib7]^ Copy number variation of one gene within 15q11.2, coding for the cytoplasmic FMRP-interacting protein 1 (CYFIP1), has been linked to both ASD and SCZ.^[@bib5],[@bib8],[@bib9]^ Furthermore, genome-wide expression profiling of patients with duplication of 15q11--q13 has specifically demonstrated upregulated *Cyfip1* mRNA in those that suffer from ASD.^[@bib10]^ Changes in CYFIP1 levels may thus lead to the neuropsychiatric and cognitive phenotypes associated with copy number variation at 15q11.2. However, the exact role that CYFIP1 has in normal nervous system function and development, and the consequences of its dysregulation, remain poorly understood.
Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.^[@bib11],\ [@bib12],\ [@bib13],\ [@bib14],\ [@bib15]^ A disruption in any of these processes produces network-wide deficits in neuronal connectivity and may help explain why changes in morphological complexity, dendritic spine number, shape and plasticity are associated with several neuropsychiatric and neurological disorders, including SCZ, ASD, ID and epilepsy.^[@bib16],\ [@bib17],\ [@bib18],\ [@bib19]^ Actin cytoskeletal dynamics have a key role in the establishment and maintenance of both dendritic arborizations and spines, and are also critical for the structural alterations in spine shape important for cellular forms of synaptic plasticity, such as long-term potentiation and long-term depression.^[@bib20],\ [@bib21],\ [@bib22],\ [@bib23]^ Moreover, alterations in the regulation of actin at dendritic spines, by neurodevelopmental disease-associated proteins such as DISC1, DTNBP1, SHANK3, PAK3, Oligophrenin and SRGAP2, have been shown to produce deficits in both synaptic plasticity and the formation and consolidation of long-term memories.^[@bib23],\ [@bib24],\ [@bib25],\ [@bib26],\ [@bib27],\ [@bib28],\ [@bib29]^
One critical modulator of cellular actin dynamics is the ubiquitous heteropentameric WAVE regulatory complex consisting of the proteins WAVE, Abi, Nap1, HSPC300 and CYFIP1 (also known as SRA-1) or CYFIP2.^[@bib30]^ The main role of CYFIP1 in this complex is to maintain the WAVE regulatory complex in an inhibited state until the small GTPase Rac1, once activated, binds CYFIP1. Rac1 binding results in dissociation of CYFIP1 from the WAVE regulatory complex, allowing WAVE to activate the actin nucleator Arp2/3 and subsequently enabling *de novo* F-actin assembly.^[@bib30],[@bib31]^ In this way, CYFIP1 functions as a key, conserved regulator of actin nucleation in cells.^[@bib30]^ Furthermore, CYFIP1 couples actin dynamics to other cellular processes, such as carrier vesicle biogenesis in the trans-Golgi network, and, via interactions with the FRMP (Fragile X mental retardation protein), regulates synaptic mRNA translation in an activity-dependent manner.^[@bib32],[@bib33]^ However, still very little is known about CYFIP1\'s role in establishing or maintaining neuronal connectivity, specifically its involvement in the regulation of dendritic morphology, synaptic structural plasticity and neurotransmitter receptor mobility. Furthermore, how both deletions and duplications affecting *Cyfip1* expression produce similar neuropsychiatric phenotypes has also not yet been addressed.^[@bib34],[@bib35]^
Here we show that both CYFIP1 and CYFIP2 are highly enriched at excitatory synapses in dendritic spines. In dissociated neurons, overexpression of CYFIP1 or CYFIP2 leads to increased dendritic complexity and altered spine morphology whereas conversely, reducing CYFIP1 levels causes decreased dendritic complexity and an increase in immature dendritic spines. CYFIP1 deficiency results in increased F-actin assembly within dendritic spines, occludes N-methyl-D-aspartate (NMDA) receptor-induced spine shrinkage and leads to alterations in the surface dynamics and synaptic mobility of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. *In vivo*, *Cyfip1* deletion in the mouse leads to delayed embryonic development and early embryonic death whereas *Cyfip1* haploinsufficiency causes reduced dendritic complexity and an increase in immature spines in the hippocampus. Our results support a critical role for CYFIP1 in development, dendritic morphogenesis and synaptic connectivity and provide further support for the idea that dysregulated CYFIP1 mediates the molecular aetiology of 15q11.2 Copy number variation-associated neuropsychiatric conditions such as ASD, SCZ and epilepsy.
Materials and Methods
=====================
Cell culture and transfection
-----------------------------
Hippocampal cultures were obtained from E16 mouse embryos (produced via *Cyfip1*^+/+^x*Cyfip1*^+/−^ crosses) or E18 rat embryos as previously described and transfected using Lipofectamine-2000 (Life Technologies, Paisley, UK).^[@bib36]^
Microscopy, quantitative analysis of neuronal and dendritic spine morphology, and fluorescence recovery after photobleaching (FRAP)
-----------------------------------------------------------------------------------------------------------------------------------
Confocal images were acquired on a Zeiss LSM700 upright confocal microscope using a 63X oil objective (NA: 1.4) unless otherwise stated (Carl Zeiss, Welwyn Garden City, UK). Image stacks for dendritic morphological and spine analysis had voxel dimensions of 0.39 μm × 0.39 μm × 0.54 μm and 0.19 μm × 0.19 μm × 0.57 μm, respectively. Neuronal arbours were reconstructed and subjected to Sholl analysis, using either Imaris (Bitplane AG, Zurich, Switzerland) or NeuronStudio and ImageJ (NIH, Bethesda, MD, USA).^[@bib37]^ Spines were manually identified on 100--200 μm long secondary dendrites and analyzed for morphological classification or volume measurements in Imaris software (Bitplane). For spine classification custom parameters were used and spines were classified into stubby, mushroom, long and thin, and filopodia categories using a ratio of spine head and neck diameters to spine length. Classification was entirely automated until the final step where errors in classification were removed.
Single-plane confocal images were acquired for localization experiments *in vitro*. To quantify CYFIP1 and CYFIP2 enrichment at synaptic sites, the fluorescence intensity of CYFIP1 or CYFIP2 was measured as the average intensity within the labelled synaptic puncta and normalized to the average intensity of the total process including synaptic puncta using Metamorph software (Molecular Devices, Sunnyvale, CA, USA).
Dendritic morphology and spines in P55--60 mice were analysed using the FD Rapid Golgi Stain kit (FD NeuroTechnologies, Baltimore, MD, USA) and Neurolucida (MBF Bioscience, Williston, VT, USA). Golgi-impregnated brains were sliced at 150 μm using a vibratome (Leica Microsystems, Heerbrugg, Switzerland). Well-isolated hippocampal CA1 neurons were imaged at 60X using the Neurolucida software system and an upright light microscope with a motorized stage (MBF Bioscience). The entire extent (apical and basal) of the dendritic tree was traced and reconstructed. For spine analysis, two apical oblique and two basal dendrites were quantified per cell. Three males were analysed for each condition with a minimum of three cells traced per animal. When using animals from separate litters, each genotype was equally represented from each litter.
Chemical long-term depression and fluorescence recovery after photobleaching (FRAP) on actin in dendritic spines was performed as described previously.^[@bib38],[@bib39]^ FRAP movies were analysed in ImageJ (NIH) using a custom-built plugin, curves were fitted using *Mathematica* (Wolfram Research, Champaign, IL, USA). For further details see [Supplementary Methods](#sup1){ref-type="supplementary-material"}.
Quantum dot (QD) imaging
------------------------
A total of 12--16DIV hippocampal cells transfected with GluA2^SEP^ were live imaged under perfusion in ACSF at 37 °C and quantum dot (QD) movies were recorded at 8.5 Hz. Labelling of GluA2^SEP^ with QDs was performed at RT using a mouse anti-GFP antibody (10 μg ml^−1^, Neuromab, N38) and an anti-mouse 605-nm QD (0.5 nM, Life Technologies). Analysis of QD receptor dynamics was performed as described (see [Supplementary Methods](#sup1){ref-type="supplementary-material"}).^[@bib40]^
Results
=======
CYFIP1 and CYFIP2 are enriched at excitatory synapses
-----------------------------------------------------
To explore the localization of CYFIP1 and CYFIP2 in neurons CYFIP1^GFP^ or CYFIP2^GFP^ ([Supplementary Figure 1](#sup1){ref-type="supplementary-material"}) were co-expressed in mature hippocampal neurons with DsRed as a marker of neuronal morphology and analysed using confocal microscopy. Compared with the localization of DsRed, which uniformly filled both dendritic processes and spines, CYFIP1^GFP^ and CYFIP2^GFP^ exhibited a nonuniform distribution appearing to be selectively targeted to punctate clusters in spines and along dendrites ([Figures 1a and b](#fig1){ref-type="fig"}). A similar enrichment in spines was observed for endogenous CYFIP1 using a CYFIP1-specific antibody and actin^GFP^ to label neuronal morphology ([Figure 1c](#fig1){ref-type="fig"}; [Supplementary Figure 1](#sup1){ref-type="supplementary-material"}). In addition, CYFIP1 is detected within the post synaptic density fraction by western blotting ([Supplementary Figure 4](#sup1){ref-type="supplementary-material"}). Co-expression experiments with CYFIP1^GFP^ and CYFIP2^mCherry^ revealed that the majority of CYFIP1^GFP^ co-localized with CYFIP2^mCherry^ and overlapping puncta were found both in dendritic processes and spines ([Supplementary Figure 2A](#sup1){ref-type="supplementary-material"}).
Using immunofluorescence and confocal microscopy, both CYFIP1^GFP^ and CYFIP2^GFP^ levels were found to be \~90% enriched at Homer and VGLUT-positive excitatory synaptic sites compared with total dendritic processes (CYFIP1, 91.4±9.8% increase, *P*\<0.001; CYFIP2, 85.9±12.6% increase, *P*\<0.001; [Figures 1d and e](#fig1){ref-type="fig"},[Supplementary Figure 2B](#sup1){ref-type="supplementary-material"}). In addition, endogenous CYFIP1 was also highly enriched at excitatory synapses and co-localized with the excitatory marker PSD-95 ([Figure 1f](#fig1){ref-type="fig"}). Thus endogenous CYFIP1, along with CYFIP1^GFP^ and CYFIP2^GFP^, are found at excitatory synapses and exhibit high levels of expression at sites of F-actin accumulation, like dendritic spines.
Overexpression of CYFIP1 and CYFIP2 enhances dendritic complexity and alters dendritic spine morphology
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Microduplication of the CYFIP1-encoding region at 15q11.2 is associated with increased neuropsychiatric disease burden, and increased expression of CYFIP1 has specifically been linked to ASD.^[@bib1],[@bib3],[@bib10]^ Overexpression of CYFIP1^GFP^ or CYFIP2^GFP^ resulted in a significant increase in dendritic complexity as a function of distance from the soma compared with control neurons expressing GFP, measured using either number of intersections or number of branch points as indicators of morphological complexity ([Figures 2a--c](#fig2){ref-type="fig"}). In addition, total dendritic length and the total number of branch points per cell were also increased in the CYFIP1 and CYFIP2 overexpressors (dendritic length: CYFIP1, 37% increase, 2876±174 μm, *P*\<0.01; CYFIP2, 33% increase, 2787±152 μm, *P*\<0.01; GFP, 2099±163 μm; branch points: CYFIP1, 48% increase, 66.5±7.0, *P*\<0.05; CYFIP2, 101% increase, 90.1±5.6, *P*\<0.001; GFP 44.8±7.7; [Figures 2d and e](#fig2){ref-type="fig"}).
To examine whether changes in dendritic complexity were accompanied by changes in excitatory spine number or shape, we measured spines in CYFIP1^mCherry^+actin^GFP^-expressing neurons at 21DIV. Compared with DsRed+actin^GFP^ transfected neurons, CYFIP1^mCherry^+actin^GFP^-expressing cells displayed no significant difference in spine density (data not shown). However, CYFIP1 overexpressors had significantly fewer stubby spines (30% decrease in stubby spines, DsRed+actin^GFP^: 0.32±0.01 spines μm^−1^, CYFIP1^mCherry^+actin^GFP^: 0.24±0.01 spines μm^−1^, *P*\<0.01) and increased numbers of long, thin spines and filopodia (24% increase in long, thin spines, DsRed+actin^GFP^: 0.14±0.01 spines μm^−1^, CYFIP1^mCherry^+actin^GFP^: 0.17±0.01 spines μm^−1^, *P*\<0.05; 145% increase in filopodia, DsRed+actin^GFP^: 0.006±0.001 spines μm^−1^, CYFIP1^mCherry^+actin^GFP^: 0.016±0.003 spines μm^−1^, *P*\<0.01; [Figures 2f and g](#fig2){ref-type="fig"}). Furthermore, spines were significantly longer in CYFIP1 overexpressors regardless of subtype classification (DsRed+actin^GFP^: 1.13±0.005 μm, CYFIP1^mCherry^+actin^GFP^: 1.29±0.005 μm, *P*\<0.0001, [Figure 2h](#fig2){ref-type="fig"}). CYFIP1 overexpression also significantly decreased spine diameter, whereas spine volume showed an overall increase due to the dominating effect of the increase in spine length ([Supplementary Figures 6C and D](#sup1){ref-type="supplementary-material"}). These results demonstrate that increasing CYFIP1 expression levels above baseline enhances dendritic complexity and alters the ratio of mature versus immature spines in neurons, thereby changing network connectivity.
CYFIP1 is essential for embryonic development and its loss leads to marked developmental delay
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To study the effects of decreased *Cyfip1* levels *in vivo*, we characterized a *Cyfip1* KO mouse^[@bib41]^ and found that deletion was embryonically lethal. However, fertilized KO oocytes from *Cyfip1*^+/−^ × *Cyfip1*^+/−^ crosses did persist up to the blastocyst stage *in vitro* (not shown), and in pregnant dams, they were detectable until embryonic day 8.5 (E8.5) postcoitum ([Supplementary Table 1](#sup1){ref-type="supplementary-material"}). At this stage, *Cyfip1* KO embryos were significantly reduced in size and displayed delayed development compared with their heterozygous (*Cyfip1*^+/−^) or wild-type (WT) counterparts ([Supplementary Figures 3A--C](#sup1){ref-type="supplementary-material"}). Further examination revealed complete developmental failure resulting in reduced body elongation and patterning. *Cyfip1*^*+/*−^ heterozygous animals on the other hand, were viable until adulthood, were fertile and did not show any gross morphological abnormalities in brain structure when compared with WT ([Supplementary Figure 3H](#sup1){ref-type="supplementary-material"}). These data suggest that adequate levels of CYFIP1 are indispensable for proper development through early stages of embryogenesis.
*Cyfip1* haploinsufficiency results in decreased dendritic complexity and increased immature spine number
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Microdeletion at 15q11.2 renders people haploinsufficient for *Cyfip1* and is associated with ASD and SCZ.^[@bib4],[@bib6],[@bib7]^ We therefore investigated the effects of decreased CYFIP1 levels by measuring dendritic and spine morphologies in *Cyfip1*^+/−^ hippocampal neurons ([Supplementary Figures 3F and G](#sup1){ref-type="supplementary-material"}). Sholl analysis of 14DIV, actin^GFP^-labelled neurons revealed that reduced CYFIP1 levels had the opposite effect on dendritic complexity to that of CYFIP1 overexpression, leading to a marked decrease in dendritic complexity between 30 and 110 μm away from the soma ([Figures 3a--c](#fig3){ref-type="fig"}). Furthermore, both total dendritic length and the total number of branch points were reduced in *Cyfip1*^+/−^ neurons compared with control (15% decrease in total dendritic length in *Cyfip1*^+/−^ neurons, WT: 2704±96.8 μm, *Cyfip1*^+/−^: 2298±80.2 μm, *P*\<0.01; 20% decrease in number of branch points in *Cyfip1*^+/−^ neurons, WT: 76.7±4.1, *Cyfip1*^+/−^: 61.4±3.6, *P*\<0.01; [Figures 3d and e](#fig3){ref-type="fig"}). Spine density was unchanged in *Cyfip1*^+/−^ neurons compared with WT controls; however, when spines were further classified into the different morphological subtypes, long and thin spines and filopodia were significantly increased (30% increase in long, thin spines, WT: 0.15±0.01 spines μm^−1^, *Cyfip1*^+/−^: 0.20±0.01 spines μm^−1^, *P*\<0.05; 125% increase in filopodia, WT: 0.007±0.001 spines μm^−1^, *Cyfip1*^+/−^: 0.016±0.003 spines μm^−1^, *P*\<0.05, respectively; [Figures 3f--h](#fig3){ref-type="fig"}). In addition, spines were significantly longer in the *Cyfip1*^+/−^ neurons irrespective of subtype classification (WT: 1.14±0.003 μm, *Cyfip1*^+/−^: 1.27±0.003 μm, *P*\<0.0001, [Figure 3i](#fig3){ref-type="fig"}). However, no change in spine diameter or volume was observed in the *Cyfip1* haploinsufficient neurons ([Supplementary Figures 6A and B](#sup1){ref-type="supplementary-material"}). These experiments demonstrate that *Cyfip1* haploinsufficiency results in decreased dendritic complexity and produces alterations in spine morphology.
CYFIP1 regulates actin assembly at dendritic spines
---------------------------------------------------
CYFIP1 negatively regulates local actin filament assembly, suggesting that actin dynamics may be altered in *Cyfip1*^+/−^ dendritic spines. FRAP of actin^GFP^ in spines of *Cyfip1*^*+/*−^ neurons revealed a significant difference in amount of fluorescence recovery compared with WT controls. Fluorescence intensity within the spine head of WT neurons returned to only 64.1±5.2% of the pre-bleached fluorescence by 40 s compared with 80.0±4.1% in the *Cyfip1*^+/−^ neurons (*P*\<0.05; [Figures 4a and b](#fig4){ref-type="fig"}). Moreover, the fluorescence recovery of *Cyfip1*^+/−^ neurons plateaued at a greater intensity than WT neurons, which was confirmed by a significant increase in the total mobile fraction (i.e. the proportion of final recovered fluorescence compared with the total bleached fluorescence, 16% increase, WT: 68.4±5.46%, *Cyfip1*^+/−^: 84.4±3.97%, *P*\<0.05; [Figure 4c](#fig4){ref-type="fig"}). However, there was no change in the recovery rate constant between *Cyfip1*^*+/*−^ and WT neurons. Similar results were also obtained using Lifeact^GFP^, an F-actin-specific fluorescent probe suitable for FRAP experiments.^[@bib42]^ Photobleaching spines expressing Lifeact^GFP^ produced a significantly greater amount of recovered fluorescence in *Cyfip1*^+/−^ neurons compared with WT again by 40 s (WT: 67.9±4.8%, *Cyfip1*^+/−^: 85.5±7.0%, *P*\<0.05; [Figure 4d](#fig4){ref-type="fig"}) resulting in a significant increase in the total mobile fraction (9.8% increase, WT: 70.1±3.03%, *Cyfip1*^+/−^: 79.9±3.12%, *P*\<0.05; [Figure 4e](#fig4){ref-type="fig"}).^[@bib42],[@bib43]^ Taken together, the increased recovery of actin^GFP^ and Lifeact^GFP^ suggests an increase in F-actin assembly in the *Cyfip1*^+/−^ spines.
*Cyfip1* haploinsufficiency occludes NMDA receptor-dependent structural plasticity
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As *Cyfip1* haploinsufficiency changes actin availability in spines and alters the ratio of mature versus immature spines at steady-state, we hypothesised that stimulus-dependent structural plasticity would also be altered in *Cyfip1*^+/−^ spines. To study the role that CYFIP1 has in spines during structural plasticity, we utilized an established chemical long-term depression protocol.^[@bib38]^ Brief bath application of 20 μM NMDA plus 20 μM glycine induces a 15--20% spine shrinkage within a timeframe of 40 min, which is measured as a decrease in spine volume without a concomitant change in either spine diameter or length ([Figures 4f and g](#fig4){ref-type="fig"}; [Supplementary Figures 6E and F](#sup1){ref-type="supplementary-material"}). Using this stimulus, we were able to induce spine shrinkage in WT neurons in response to NMDA treatment ([Figures 4f and g](#fig4){ref-type="fig"}). Cumulative frequency curves of spine volume show a leftward shift following NMDA application in WT neurons, indicating a reduction of spine volume across the population ([Figure 4h](#fig4){ref-type="fig"}). *Cyfip1*^+/−^ spines showed no change in spine volume following NMDA application and spine volume remained unchanged from its basally low levels (16% decrease in WT spine volume following NMDA treatment, no change in *Cyfip1*^+/−^ spine volume following NMDA treatment, WT saline: 0.30±0.003 μm^3^, WT NMDA: 0.25±0.001 μm^3^, *Cyfip1*^+/−^ saline: 0.26±0.001 μm^3^, *Cyfip1*^+/−^ NMDA: 0.26±0.002 μm^3^, *P*\<0.0001; [Figures 4f--h](#fig4){ref-type="fig"}). These data reveal a role for CYFIP1 in mediating structural reorganization during synaptic plasticity, possibly through dynamic regulation of the local actin cytoskeleton in spines.
Altered surface AMPA receptor mobility due to *Cyfip1* haploinsufficiency
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AMPA receptors mediate fast excitatory synaptic transmission within the CNS.^[@bib44],[@bib45]^ Actin dynamics in spines have a major role in coordinating the delivery and removal of AMPA receptors and the strength of synapses.^[@bib45]^ To address whether CYFIP1-mediated alterations in spine morphology and actin dynamics also impinge on the stability or mobility of AMPA receptors within synapses, we investigated whether surface GluA2-containing receptor dynamics were different from control in *Cyfip1*^+/−^ neurons. Initial observations suggested that total protein levels of the AMPA receptor subunit GluA2 are unchanged in WT and *Cyfip1*^+/−^ neurons ([Supplementary Figures 5A and B](#sup1){ref-type="supplementary-material"}). Therefore, we expressed pH-sensitive superecliptic pHluorin (SEP)-tagged GluA2 in neurons to visualize GluA2-containing synaptic clusters in dendrites. Single GluA2^SEP^-containing receptors were labelled with 605 nm QDs to follow the diffusion of individual receptors within synaptic clusters.^[@bib40]^ QD-labelled GluA2^SEP^ receptors were less mobile when inside synaptic clusters (*D*~in~=0.023 μm^2^ s^−1^, *D*~out~=0.057 μm^2^ s^−1^ where *D* is the median diffusion coefficient, *P*\<0.0001, [Supplementary Figures 5C and D](#sup1){ref-type="supplementary-material"}), indicating confined motion at synapses, as previously shown.^[@bib46]^ In *Cyfip1*^+/−^ neurons, however, GluA2^SEP^-containing receptors exhibited an increased synaptic mobility within clusters when compared with WT neurons, (WT: *D*~in~=0.023 μm^2^ s^−1^, *Cyfip1*^+/−^: *D*~in~=0.034 μm^2^ s^−1^, *P*\<0.01; [Figures 4i and j](#fig4){ref-type="fig"}) as well as a reduced confinement at synapses ([Supplementary Figure 5E](#sup1){ref-type="supplementary-material"}). GluA2^SEP^ receptor mobility outside synapses remained unchanged between WT and *Cyfip1*^+/−^ neurons (WT: *D*~out~=0.057 μm^2^ s^−1^, *Cyfip1*^+/−^: *D*~out~=0.062 μm^2^ s^−1^, [Figure 4k](#fig4){ref-type="fig"}). These observations suggest that the restricted mobility of GluA2 receptors at synapses is significantly diminished in *Cyfip1*^+/−^ spines.
CYFIP1 regulates neuronal development and connectivity *in vivo*
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To confirm that *Cyfip1* haploinsufficiency produces similar effects on dendritic spines in the intact animal, we investigated dendritic complexity and spine morphology in the hippocampi of WT versus *Cyfip1*^+/−^ mice using Golgi staining. *Cyfip1* haploinsufficiency in postnatal day 55--60 (P55--60) animals was confirmed by western blotting (46.8% CYFIP1 protein decrease, WT control 100±15.4%, *Cyfip1*^+/−^ 53.2±7.8%, *P*\<0.05; [Supplementary Figures 3D and E](#sup1){ref-type="supplementary-material"}). Compared with WT male littermate controls, CA1 neurons in *Cyfip1*^+/−^ animals possessed a significantly decreased dendritic complexity within 100 μm from the soma ([Figures 5a and b](#fig5){ref-type="fig"}). Furthermore, spine density was unchanged, but long and thin spines were increased in the apical oblique dendrites in *Cyfip1*^+/−^ animals (40% increase, WT: 0.56±0.066 spines μm^−1^, *Cyfip1*^+/−^: 0.79±0.078 spines μm^−1^, *P*\<0.05; [Figures 5c and d](#fig5){ref-type="fig"}). These results indicate that genetic dysregulation of *Cyfip1* produces penetrant effects on pyramidal neuron dendritic complexity and spine morphology *in vivo*.
Discussion
==========
Altered levels of CYFIP1 are associated with several neurological disorders including SCZ and ASD.^[@bib4],[@bib5],[@bib10]^ However, it remains unclear what role CYFIP1 has in the establishment or maintenance of neuronal connectivity in the mammalian CNS, and how changes in its expression contribute to neurological dysfunction. Here we report that CYFIP1 regulates the maturation of neuronal dendrites and dendritic spines, controls the availability of F-actin within spines and impacts both spine structural plasticity and mobility of AMPA receptors at synapses. Furthermore, modelling SCZ- and ASD-associated *Cyfip1* haploinsufficiency in mice produces deficits in dendritic complexity and spine morphology in hippocampal pyramidal neurons *in vivo*.
The activity of Rho GTPases (including RhoA, Rac1 and Cdc42) is associated with increased dendritic branch dynamics and extension.^[@bib20],[@bib21],[@bib47],[@bib48]^ Activation of Rac1 releases the inhibitory action of CYFIP1 on WAVE, potentiating Arp2/3-mediated actin polymerization suggesting that changes in CYFIP1 levels could alter signalling events downstream of Rac1.^[@bib31]^ Here we demonstrate that CYFIP1 expression levels are important for dendritic arborization and neuronal morphological complexity. Overexpression of CYFIP1 in hippocampal neurons *in vitro* leads to an increase in dendritic length and complexity whereas conversely, neurons from *Cyfip1*^+/−^ animals have smaller, less complex dendrites both *in vitro* and *in vivo*. Interestingly, in addition to the effects on dendritic morphogenesis that we report here, both WAVE1 and CYFIP1 have previously been implicated in axonal outgrowth.^[@bib49],[@bib50]^
A strict spatiotemporal balance between actin polymerization and turnover, mediated by Rho GTPases, is also important for spine formation, maturation and stability.^[@bib20],[@bib21]^ We report that CYFIP1 is highly enriched in dendritic spines where it co-localizes with actin. Thus, CYFIP1 is critically placed, as a key Rac1 effector, to locally regulate WAVE in spines, and variations in its expression levels are likely to impact on Arp2/3-dependent spine actin dynamics downstream of Rac1. In agreement with this, we find that downregulating CYFIP1 expression levels *in vitro* or *in vivo* drives an increase in the ratio of immature-to-mature spines suggesting that CYFIP1 is important for actin-dependent regulation of spine maturation. Furthermore, we show that dendritic spines from *Cyfip1*^+/−^ haploinsufficient neurons display enhanced F-actin availability suggesting that spatiotemporal control over actin polymerization is altered at *Cyfip1*^+/−^ postsynaptic sites. A role for CYFIP1 in the regulation of Rac1-dependent F-actin assembly in *Drosophila* NMJ presynaptic terminals was also recently demonstrated, where it was shown to be important for synaptogenesis and presynaptic quantal content.^[@bib51],[@bib52]^ In addition to previous functions described for CYFIP1 in the regulation of mRNA translation in dendrites and mGluR-long-term depression, our results suggest that CYFIP1 also has a vital role in the local regulation of spine actin dynamics via WAVE and Arp2/3.^[@bib32],[@bib35]^ This is in agreement with a recent study showing that CYFIP1 translocates between the FMRP-containing protein synthesis machinery and the actin-regulatory complex, and that disrupting CYFIP1\'s interaction with members of either complex negatively impacted spine maturation in neurons.^[@bib34]^
The surface mobility of neurotransmitter receptors is dynamically regulated to control synaptic activity and is emerging as another key component underlying plasticity at nerve terminals.^[@bib40],[@bib53],[@bib54]^ The trapping of mobile AMPA receptors within the postsynaptic domain is thought to be critical for maintaining and strengthening synaptic communication, and a pathological impairment in this process could have significant implications for neurotransmission.^[@bib55]^ The enrichment of CYFIP1 at excitatory synapses implies that CYFIP1 can locally regulate actin cytoskeletal dynamics in the postsynaptic domain. This fine-tuning of actin turnover has previously been demonstrated to be an important regulator of synaptic glutamate receptor mobility. Indeed, we find that the disruption of spine maturation due to decreased CYFIP1 levels also correlates with an increase in AMPA receptor mobility within the spine postsynaptic density. Consequently, CYFIP1 expression levels appear to be critical not just for the maturation of dendritic spines but may also be important for regulating the subsynaptic cytoskeletal architecture essential for the stabilization of postsynaptic AMPA receptors.
Dynamic regulation of F-actin assembly is repeatedly implicated in mechanisms underlying spine structural plasticity.^[@bib21],[@bib56],\ [@bib57],\ [@bib58],\ [@bib59],\ [@bib60],\ [@bib61]^ We observe that NMDA receptor-induced spine remodelling no longer occurs in *Cyfip1*^+/−^ neurons, suggesting that when CYFIP1 levels are reduced, F-actin assembly is basally overactive and cannot induce further spine remodelling in response to NMDA. CYFIP1 has been previously shown to couple local actin polymerization to membrane budding at subcellular compartments such as the trans-Golgi network.^[@bib33],[@bib62]^ Therefore, it will be interesting in the future to determine if the coupling of activity-dependent AMPA receptor trafficking (e.g., at the Golgi or in the endocytic network) to alterations in spine volume is also disrupted upon CYFIP1 depletion.^[@bib63]^
Our results suggest that CYFIP1 is part of a growing number of mental illness-associated actin-regulatory molecules, including DISC1, DTNBP1, SHANK3, SRGAP2, Oligophrenin and the Abi1-WAVE2 complex that act in Rac1-dependent pathways to regulate dendritic development and spine dynamics.^[@bib24],\ [@bib25],\ [@bib26],\ [@bib27],\ [@bib28],\ [@bib29]^ As we observe an increase in immature spines upon CYFIP1 overexpression or haploinsufficiency *in vitro*, it is interesting to note that several other proteins known to signal via actin-regulatory pathways have been shown to drive similar effects on spine structure when either up- or downregulated, including VCP/neurofibromin, NESH/Abi-3 and Cofilin.^[@bib47],[@bib48],[@bib57],[@bib64],\ [@bib65],\ [@bib66],\ [@bib67]^ Thus, the precise tuning of CYFIP1 expression levels may be crucial for stabilising synaptic contacts, and skewing its levels above or below a critical threshold may force spines into a structurally unstable state. This may explain why both deletions and duplications of CYFIP1 have been linked to major mental illness.
Recent work has highlighted that rare complete gene knockouts in humans have a significant role in ASD and major mental illness.^[@bib68]^ Although both deletions and duplications of CYFIP1 have been identified, total loss of CYFIP1 in humans seems unlikely as we report here that complete CYFIP1 deletion in mice leads to a failure in early embryonic development with *Cyfip1*-null embryos unable to survive beyond E8.5. Similar developmental abnormalities, resulting in death during early embryogenesis, have been observed in mice lacking other critical actin-regulatory genes such as *Rac1* and the WAVE complex component *Nap1*. Deletion of these genes in the mouse cause death during gastrulation at E7.5 and E9, respectively.^[@bib69],\ [@bib70],\ [@bib71]^ Therefore, throughout early mouse development, CYFIP1 signalling events, probably via its core conserved actin-regulatory functions, are likely critical for gastrulation and normal patterning of embryonic structure in addition to later roles in neuronal development and plasticity.^[@bib72]^ The embryonic lethality observed in the CYFIP1 knockout suggests that CYFIP2 cannot compensate for all CYFIP1 functions. Intriguingly, we also observed CYFIP2 to be enriched in dendritic spines and its overexpression could drive increased dendritogenesis. This suggests that it will be interesting to further explore whether CYFIP2 is a candidate susceptibility gene for major mental illness.
Our results provide important new insights into the role CYFIP1 has in the development of the nervous system and how *Cyfip1* dysregulation can alter CNS function to contribute to the development of neuropsychiatric illness. Changes in the structure and function of excitatory synapses, and alterations in the local versus long-range dendritic connectivity of neurons, have both been associated with the development of neuropsychiatric conditions involving imbalances of excitation and inhibition, such as ASD and SCZ.^[@bib73],[@bib74]^ The roles for CYFIP1 described here may help inform how altered levels of this molecule gives rise to network-level dysfunction that define these pathologies.
We thank Professor M Häusser for kindly providing access to the Neurolucida system and Dr B Clark and Dr A Roth for their help and advice on using the Neurolucida system. We thank Kittler lab members for constructive discussions. This work was supported by the United Kingdom Medical Research Council Senior Non-Clinical Fellowship (MRC; GO802377; JTK). ECD is an MRC-funded student on the MRC Laboratory for Molecular Cell Biology 4-year graduate programme. DFS is in the University College London (UCL) Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (COMPLEX) PhD Programme.
[Supplementary Information](#sup1){ref-type="supplementary-material"} accompanies the paper on the Translational Psychiatry website (http://www.nature.com/tp)
The authors declare no conflict of interest.
Supplementary Material {#sup1}
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[^1]: These two authors contributed equally to this work.
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Q:
Property in service not updated
Having a little trouble with my authentication service. I basically have this on my service:
angular.factory('authentication', [..., function() {
var currentUser = {};
return {
login: function() {
currentUser = { username: 'Foo' };
},
logout: function() {
currentUser = {};
}
user: currentUser;
}
})]
And in my AppCtrl, I have this:
angular.module('App').controller('AppCtrl', [..., function() {
$rootScope.$on('$stateChangeSuccess', function() {
console.log(authentication.user);
});
}]);
In my LogoutCtrl, I have this:
angular.controller('LogoutCtrl', [..., function() {
authentication.logout();
$state.go('login');
}]);
Once the state changes to login, the console still prints username: 'Foo'.
Any ideas?
A:
When you make the first assignment in the object you are referring to the reference of the user. You then replace that reference when you call logout() so your old user, bound earlier, is unchanged. Change it to a getter function instead:
...
getUser: function() {
return user; // always the correct reference
}
Now call that in the console.log and it will work
|
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