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A new report by influential UK thinktank Chatham House says the potential threat Russia poses to the Baltic states is real, and NATO needs to up its game considerably if it is serious about providing deterrence and defense.
Titled Russia's 'New' Tools For Confronting The West, the 72-page report argues that while it has become fashionable to describe Russia's approach to as all-new, in fact most elements of so-called "Hybrid War" have deep roots within the Russian military and society.
"Russia intends to develop the capability to operate against several neighbors at once...This realization has led to sudden retrospective attention to the major exercises which Russia had been conducting for a number of years – and the implications of their scenarios for the neighbors who appear to be targeted," the report says, questioning whether NATO has the capability to mount a "swift and effective military response" in such circumstances.
"In Russian thinking, conventional military power deficiencies present a temptation and an invitation. Weakness provokes, but readiness deters. Consequently, the relative military vacuum in the Baltic states must urgently be filled by NATO, before Russia is tempted to fill it itself," the report says.
"If NATO is not willing or able to pre-position sufficient forces in the Baltic states to close off easy opportunities for Russia, then in order to fulfil its function and reason for existence it must be prepared to accept much more costly and politically challenging alternatives."
Estonia, Latvia and Lithuania are widely considered the most likely next potential victims of Russian intervention, but are not the only candidates, the report suggests, with Sweden in particular repeatedly threatened. However, constant reports in Western media about the likelihood of the Baltic states being attacked could actually have a deleterious effect on those countries' economies.
The Kremlin is not above personal intimidation either with servicemen in Latvia confronted with "Russian intelligence officers reeling off details of their personal lives" taken from social media posts.
Recent increases in the NATO presence in the Baltic states provide some deterrent effect but their actual military value may not be as large as they seem, argues the report:
"Despite the availability of a small amount of (primarily US) military equipment already delivered to the Baltic states, in order to reach these three countries any forces seeking to protect them would have to run the gauntlet of Russian naval and air forces in the Baltic Sea...One-third of Poland and substantial parts of the territories of other NATO members and partners are under Russian integrated air defence system (IADS) coverage."
The report concludes that the risk of conflict between Russia and the West is unlikely to disappear any time soon, with Russia's neighbors obviously at greatest risk:
"Russia’s security initiatives, even if it views or presents them as defensive measures, are likely to have severe consequences for its neighbors. Russia’s growing confidence in pursuing its objectives will make it even harder for the West to protect itself against Russian assertiveness, without the implementation of measures to resist Russian information warfare, and without the availability of significant military force to act as an immediate and present deterrent in the front-line states."
The full report is available HERE. |
Since today is International #IPAday (click here to read more about it), I thought that I would write a review of a beer that most Craft Beer drinkers know very well: Stone Brewing Company’s India Pale Ale.
Actually, #IPAday is my second reason for writing this review. My first reason is because of a Twitter conversation that I had last night concerning the subject of Comfort Beer. Here’s a brief snippet of what was said …
Brewniversal: Would you rather sit at a bar that has 100 different basic #craftbeer taps or a bar that has 10 special/limited taps?
Ryanhudak: I’d go with the special/limited at this point. The basics you can find anywhere anytime.
Boozedancing: New phrase… #ComfortBeer
Brewniversal: I like that… #beersecurityblanket
Boozedancing: Good, but a bit tough to say when your done with a few elusive #CraftBeer and need a #ComfortBeer.
Ryanhudak: What are your #ComfortBeers? Great Lakes Eddie Fitz is definitely one of mine.
Boozedancing: #ComfortBeers : @oskarblues Dales Pale Ale, @GLBC_Cleveland Eddie Fitz, @smuttynosebeer Finest Kind IPA, @BPbrewing Sculpin, @greenflashbrew West Coast IPA, #SaisonDupont, @VictoryBeer Prima Pils.
So what is Comfort Beer? Comfort Beer is the beer that you select when you don’t want to take chances on a new beer, and instead pick something that you are familiar with, and that you KNOW will be good. Stone IPA definitely falls into the Comfort Beer category.
Here’s what I think of this beer…
Appearance: Cloudy, pale orange color. Fluffy one inch head that dissipates slowly. Lots of fast rising bubbles. Very little lacing.
Cloudy, pale orange color. Fluffy one inch head that dissipates slowly. Lots of fast rising bubbles. Very little lacing. Aroma: Big dose of orange and grapefruit. Honey. Piney hops.
Big dose of orange and grapefruit. Honey. Piney hops. Taste: Medium carbonation. Starts off with some citrus and honey sweetness. The hops take over at mid-palate and lead you to a pleasant and lingering bitter finish. Thanks to a solid malt backbone, the bitterness is never overwhelming.
Medium carbonation. Starts off with some citrus and honey sweetness. The hops take over at mid-palate and lead you to a pleasant and lingering bitter finish. Thanks to a solid malt backbone, the bitterness is never overwhelming. ABV: 6.9%
Since this is such a well known beer, I was a bit hesitant to write this review. What could I possibly say that hasn’t already been said? It has been reviewed 2,440 times on Beer Advocate and has an A for its overall rating. It has been reviewed 2,515 times on Rate Beer and is currently ranked #6 against other IPAs. Although I will occasionally go against the crowd, this is not one of those occasions. Stone’s IPA is a delicious and well balanced beer that does a really good job of hiding it’s relatively high alcohol content. Although you could probably drink this all night, I wouldn’t recommend it. This beer will definitely creep up on you.
What will you be drinking to celebrate International #IPAday? Let us know in the comments below. |
Severe Weather
DA: 2 township Dems charged with voter fraud
Two Democratic western Pennsylvania township officials were charged with voter fraud for allegedly soliciting absentee votes from elderly residents who weren't eligible to cast such ballots.
An investigative grand jury recommended the charges filed Friday by state police.
"I think every citizen should have faith that the electoral system be played on an even playing field with the rules being obeyed and, when violated, the violators be penalized," said Fayette County District Attorney Jack Heneks, who is a Democrat in a county where nearly 70 percent of registered voters also belong to the party.
William Geary, 62, and Thomas Keefer, 58, both Bullskin Township supervisors, will be scheduled for a preliminary hearing after they receive mailed court summonses advising them of the charges.
The grand jury was convened after Democratic nominee David Butler complained after losing to Keefer in the November 2011 general election by nine votes. Keefer, an incumbent, had lost the May 2011 Democratic primary to Butler, but got 741 votes compared with 732 for Butler after waging a write-in campaign that November.
The grand jury found that Keefer and Geary, another incumbent, visited 13 elderly voters' homes to help them complete the ballots despite knowing the voters were physically able to vote in-person on Election Day. Both men also failed to fill out declarations of physical disability with the ballots, which certify that the voters wouldn't be able to vote in-person, the grand jury found.
The grand jury found Keefer obtained six votes that way, while Geary obtained seven more votes for Keefer the same way.
Keefer's defense attorney, Jack Purcell, said his client is innocent. Geary couldn't immediately be reached for comment, and he doesn't have an attorney listed in court papers.
Copyright 2013 by The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Forty years ago, one of the greatest boxing matches in history took place in an unlikely setting: the capital of the Philippines. Muhammad Ali's epic win over great rival Joe Frazier in 1975 became known as the "Thrilla in Manila."
Israeli Prime Minister Benjamin Netanyahu warned Tuesday that a proposed agreement between world powers and Iran was "a bad deal" that would not stop Tehran from getting nuclear weapons -- but would rather pave its way to getting lots of them and lea... |
/**
* Copyright Amazon.com, Inc. or its affiliates. All Rights Reserved.
* SPDX-License-Identifier: Apache-2.0.
*/
#include <aws/wafv2/model/ListLoggingConfigurationsRequest.h>
#include <aws/core/utils/json/JsonSerializer.h>
#include <utility>
using namespace Aws::WAFV2::Model;
using namespace Aws::Utils::Json;
using namespace Aws::Utils;
ListLoggingConfigurationsRequest::ListLoggingConfigurationsRequest() :
m_scope(Scope::NOT_SET),
m_scopeHasBeenSet(false),
m_nextMarkerHasBeenSet(false),
m_limit(0),
m_limitHasBeenSet(false)
{
}
Aws::String ListLoggingConfigurationsRequest::SerializePayload() const
{
JsonValue payload;
if(m_scopeHasBeenSet)
{
payload.WithString("Scope", ScopeMapper::GetNameForScope(m_scope));
}
if(m_nextMarkerHasBeenSet)
{
payload.WithString("NextMarker", m_nextMarker);
}
if(m_limitHasBeenSet)
{
payload.WithInteger("Limit", m_limit);
}
return payload.View().WriteReadable();
}
Aws::Http::HeaderValueCollection ListLoggingConfigurationsRequest::GetRequestSpecificHeaders() const
{
Aws::Http::HeaderValueCollection headers;
headers.insert(Aws::Http::HeaderValuePair("X-Amz-Target", "AWSWAF_20190729.ListLoggingConfigurations"));
return headers;
}
|
Related Stories
We don’t need to ban bullets. We need to find fathers, champion them, and encourage — demand — they step up and be fathers.
Rather than promote populist anti-gun policies, which is the easy thing to do but the least likely to produce a positive result, let’s get back to promoting family. Fathers matter.
When violence occurs, some are quick to blame poverty and lack of employment and opportunity.
But lack of money and employment are symptoms of a disease; lack of fathers.
Guns are also blamed and gun control advocated, but guns are just a tool used by a violent individual.
By the time a young man — disproportionately, it is young men — lets the bullets fly, he has been on the wrong path for some time.
Some of the toughest gun control cities in the U.S. have the most violent crime. The reason is obvious. The gun isn’t the actual problem.
The National Fatherhood Initiative in the United States reports that, according to census figures, “Children in father-absent homes are five times more likely to be poor. In 2002, 7.8% of children in married-couple families were living in poverty, compared to 38.4% of children in female-householder families.”
Meanwhile, there is a correlation between the lack of a father and a life that leads to prison.
According to “Father Absence and Youth Incarceration,” in the Journal of Research on Adolescence, “Even after controlling for income, youths in father-absent households still had significantly higher odds of incarceration than those in mother-father families. Youths who never had a father in the household experienced the highest odds.”
A review of the 2010 Emmy-nominated film, Crips and Bloods: Made in America, which shines a spotlight on the gang problem in South Central Los Angeles, reads, “the one theme that each of the experts, gang members and leaders keep repeating is fatherlessness. Fatherless boys are the ones joining gangs. Fatherless boys are the ones who are shooting each other by the thousands. Fatherless boys who are looking for family.”
In November 2011 Hugh Segal, Conservative senator for Kingston-Frontenac-Leeds wrote, “Less than 10% of Canadians live beneath the poverty line but almost 100% of our prison inmates come from that 10%. There is no political ideology, on the right or left, that would make the case that people living in poverty belong in jail.”
No, but there exists a political ideology that refuses to correlate immoral personal behaviour with poverty and violence in the community. That ideology blames anything else.
If we know people in prison are poor and fatherless, and that poor people are also statistically much more likely to be fatherless, we should do what?
Ban guns and bullets? Advocate for more government income transfers to poor people?
We could do that if, for some reason, we don’t want to aggressively advocate against teen motherhood and the irresponsible fathering (but not raising) of children.
Too many people shy away from that, afraid it sounds moralistic.
The cycle of young men fathering children with young women, who have yet to finish high school, consigns children to a cycle of poverty and violence. How is that not immoral?
Politicians are always looking for a magic bullet solution to crime. His name is “Dad.” |
Ecmel Kutay
Ecmel Kutay (1927 – 17 March 1998) was a general in the Turkish military and served as the 24th Mayor of Istanbul from 1981 to 1982.
References
Category:Turkish Military Academy alumni
Category:Army War College (Turkey) alumni
Category:Turkish Army generals
Category:Mayors of Istanbul
Category:1927 births
Category:1998 deaths |
Kidney involvement and renal manifestations in non-Hodgkin's lymphoma and lymphocytic leukemia: a retrospective study in 700 patients.
Renal involvement as part of systemic lymphoma (LY) is quite frequent, however, primary extranodal renal non-Hodgkin's lymphoma (NHL) is extremely rare, and only about 65 cases have been reported in the world literature. In a retrospective study of renal manifestations in 700 patients with documented LY and chronic lymphocytic leukemia (CLL) seen at our hospital during 1986-95, 83 patients had signs of acute renal failure. Only five of these had proven renal infiltration, but none of them satisfied the criteria for primary renal LY. Glomerulonephritis (GN) has also rarely been reported in association with LY and CLL, and only 37 glomerular lesions in NHL and 42 in CLL have been documented, respectively. GN may precede, coexist, or follow the diagnosis of LY by several years. Of the 42 cases of CLL reported worldwide, 36 had nephrotic syndrome. Renal failure was seen in about one third. The most common glomerular lesion reported is membranoproliferative GN, followed by membranous GN. In our study, we found only five biopsy-proven cases with GN amongst the 700 patients seen. In this report we also briefly describe some rare interesting associated renal syndromes in CLL and NHL. |
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Thursday, April 22, 2010
Happy Earth Day! I do hope you are able to get outside today. So, I wanted to tell you about Sprig Toys. It all began at the Type-A Mom conference last September where these smiley people were displaying some cute eco-friendly toys. I sauntered over to the table, spent some time talking to them, touching the toys and envisioning how excited the kids would be to see these. Then they sent me home with Rex Jungle the dinosaur and two of the guides.
The kid were crazy about these toys and I think you will be as well. So, why talk about Sprig on Earth Day? Well, these toys required no batteries (yes, that means kid-powered toys), earth-friendly materials and paint-free.
I bet you are wondering What are they made of? They are a bio-composite made from recycled plastics (usually polypropylene) and reclaimed wood. The company tries to incorporate wood so they can use less plastic.
Now, you are thinking, Why are there no facial features? After noting that so many toys recalls were due to lead paint issues, they decided to leave the faces plain. At first, I thought the kids would be bothered by this and although, they did notice and ask why the faces were blank, they were happy with my reply 'so you can use your imagination'. This way, little people/guides can be happy or sad or grouchy. My kids are currently being taught by daddy to roll their eyes (why must he?) so I expect to hear that the sprig people are as well.
This company goes eco-friendly beyond the toy itself: The packaging is minimal (no annoying ties and plastic clam shells) and is made from recycled materials. In addition, the product boxes are printed with soy or water based inks as well as their product brochures that are printed on FSC certified paper with high recycled content. And finally, they are even recyclers to the max in their corporate offices and some even bike to work. Speaking of their offices and great people, feel free to reach out to the company via Twitter @kimatsprig
We have a great time playing with the Dolphin Boat Explorer in the tub and next up for us this spring will be to order The trucks!In addition, I wanted to share that another favorite imagination inspiring toy: our Wooden Blocks. Although they are not made of reclaimed wood, we have used them for three years now and I expect we will for three more. I feel good about that because, it is one less plastic toy being tossed into a land-fill at the end of a few months. |
Story highlights Rand Paul made a high-profile trip to Iowa this week
Iowa is a magnet for presidential hopefuls
Paul made headlines for changing his tune on foreign aid
Experts say the controversy isn't a deal breaker, but he still needs social conservatives
Rand Paul wears his political ambition for all to see. Look no further than the tie he sported during a three-day trip to Iowa. It had yellow images of corn, the crop that epitomizes politics in the first-in-the-nation caucus state.
"And by coincidence, I have one in the shape of South Carolina," the Kentucky Republican said Wednesday, drawing laughs.
He was speaking at a Republican breakfast outside Des Moines at Machine Shed, a Midwest restaurant chain where the waiters wear overalls and drinks are served in Mason jars.
As Paul blitzed across the Hawkeye State this week, holding events at Iowa GOP offices and campaigning for local candidates, he hardly played coy to the question of whether he was running for President. After all, his nine-city trip marked his fourth visit to the state since the 2012 election.
JUST WATCHED Rand Paul questioned on Israel Replay More Videos ... MUST WATCH Rand Paul questioned on Israel 02:16
"I don't know why Iowa keeps popping up on my calendar, but it seems to be pretty frequent," he said Monday, clearly with sarcasm.
His itinerary this time included a campaign-style schedule where he continued testing his 2016 message on the road.
From reducing the federal deficit to defending civil liberties and reforming the criminal justice system, Paul mostly stayed on his talking points.
But the trip was not without controversy.
His combative answer to a reporter's question -- combined with video of Paul appearing to avoid an immigration activist — absorbed most of the attention surrounding his visit.
Experts say it's unlikely those story lines will derail any progress Paul has made in the state with voters, but his comments could underscore questions some Republicans have about his foreign policy, especially as he seeks to broaden his appeal.
Off-message
At his first stop on Monday, which actually took place in Omaha, Nebraska, near the Iowa state line, Paul held a news conference after touring a tech startup venue with Nebraska GOP Senate hopeful Ben Sasse.
Asked if he still supported phasing out foreign aid to Israel, Paul fired back at a reporter for "mischaracterizing" his position and staunchly denied that he had ever proposed such legislation.
But it's well-documented that he called for ending all foreign aid, including assistance to Israel, and sought support in Congress for his proposal in 2011.
In Iowa, Paul stressed that he never introduced legislation that solely "targeted" Israel and argued that he strongly favors sending money to the country.
Still, he added, Israel will be better positioned in the long run without foreign assistance.
"Every country ultimately would be better off to be independent," he said on Tuesday.
Paul is also taking heat for quickly exiting a tense moment when an immigration activist confronted Rep. Steve King at a fundraiser while the two lawmakers ate dinner Monday night.
Video of the incident shows Paul, at the behest of his press aide, quickly getting up from the table and getting away from the confrontation. Paul said he was stepping away to do interviews with local media.
Whether or not those interviews were hastened because of the activist is unclear. Still, the video quickly spread and it was enough for critics to frame a narrative that Paul bolted from an uncomfortable exchange.
The dust-ups in his trip made headlines and ate up much of the coverage of his Iowa visit.
David Kochel, Mitt Romney's Iowa strategist in 2008 and 2012, said he doubts caucus voters will judge Paul negatively for leaving after "someone tried to sandbag him."
"I think he's fine on that," he said. "As for Israel, that's a little more difficult. You have social conservatives in Iowa who very much feel the need to be in solidarity with Israel -- not just Christian conservatives, but it's also national security conservatives."
While Paul has voted in favor of sending more aid to Israel this year and has proposed cutting off aid to the Palestinians, his past statements and views on foreign policy are rooted in his libertarian leanings — a perspective still largely outside of mainstream Republican thought.
"He'll probably have work to do on that issue," Kochel continued. "It could be one of those things that might limit his potential."
Still, Kochel thinks Paul is the current frontunner in Iowa among prospective candidates. He points to Paul's frequent travel to the state, his efforts to build a wider GOP, and the network of supporters built by his father's presidential campaigns the past two cycles.
'Son of Ron'
In the 2012 Iowa caucuses, former Rep. Ron Paul of Texas finished with 21% of the vote, just slightly behind Romney and former Sen. Rick Santorum — who tied for first at 25%.
Many of Ron Paul's supporters were previously inactive in politics, citing a lack of candidates who represented their views.
"Your father cured my apathy," one man told Rand Paul at an event in Council Bluffs.
Building off Ron Paul's 2012 momentum, the so-called liberty faction of Iowa's Republican Party eventually took control of party leadership.
Mainstream Republicans, with the support of Iowa Gov. Terry Branstad, wrestled back control earlier this year.
But Paul knows he needs more than just the libertarian wing of the party. As seen in his trip this week, he's going after the state's social conservatives and business Republicans, too.
"Paul is attempting to pivot from being 'Son of Ron,' so to speak," said Dennis Goldford, professor of politics at Drake University in Des Moines. "He's never going to deny that or reject it. But he has the view that Republicans need a broader base or broader range than some other candidates have maintained."
Paul spoke at five GOP offices this week and five other events in a tour that took him around the state in a 730-mile loop. At each stop, Paul's main message sought to counter post-2012 perceptions that the Republican Party should change its message.
"I say 'hell no.' We have to be more boldly for what we're for," he said at the GOP office in Davenport. It's a mantra he has repeated in his travels across the country this year.
But he proposes doing so with some traditional and unorthodox ideas for mainstream Republicans. Part of that includes a push to speak out against domestic surveillance programs and mount a strong defense of the Fourth Amendment.
He has also been aggressive in courting voters and even Democrats to help expand the party. To do that, he's urging for reform to the criminal justice system with reduced sentences for nonviolent drug offenders and the restoration of voting rights to nonviolent felons after they get out of jail.
In Northwest Iowa, home to many of the state's social conservatives, Paul placed an evangelical spin on his message.
"Many of us are Christians, we believe in a second chance in our religion. Anybody here who's not a sinner, raise their hand," he said Monday night at a fundraiser in Okoboji. "We believe in redemption, should the law allow people a second chance."
But that's about as deep as Paul waded into social issues during the trip. He didn't talk about abortion, contraception or same-sex marriage until audience members asked him about the issues at one of his final events.
Asked whether he supported a constitutional amendment banning same-sex marriage, Paul said he "favors the concept" of traditional marriage but argued the federal government should stay out marriage entirely.
"I don't want to register my guns in Washington or my marriage," he said.
The previous past two winners of Iowa caucuses, Santorum and Mike Huckabee, both ran on a vocal platform with regard to social issues. Goldford said if Paul doesn't devote more attention to those topics, someone else will step in to fill in the void.
"To function in Iowa he's going to have to address the concerns of conservative evangelicals because Marco Rubio and Ted Cruz are going to do that," he said.
Paul left Iowa before this weekend's annual summit hosted by the Family Leader, a group that's influential with social conservatives in the state. Guest speakers include Cruz, Huckabee, Santorum, Texas Gov. Rick Perry and Louisiana Gov. Bobby Jindal.
Paul said he couldn't make it due to a scheduling conflict. But he indicated he'd be back.
"You have to meet people four, five, six times in Iowa because they expect a real personal touch, and I think it's actually one of the good things about the process," he told reporters, before needlessly adding: "if I decide to do this." |
7/07/2003 @ 12:00AM
Pay Up!
A promising way to curb spam: Charge the sender.
Hoping to stop the evil epidemic of spam,
Philip Raymond
is putting a price on it. The 46-year-old software executive has a provisional patent on a service called Vanquish, which requires e-mail senders to post a cash bond of 5 cents into a bank account for every piece of e-mail they send. If a recipient judges the mail to be illegitimate, the sender loses the nickel, with four pennies going to the recipient’s Internet service provider and one penny going to Vanquish as a processing fee. If the recipient okays the message, that sender is cleared from then on. But if the human or machine behind the spam won’t post a bond, the message doesn’t go through.
With Internet service providers processing 6.9 billion spam messages a day, the price for senders could add up quickly. “We don’t search for combinations of words and numbers,” Raymond says. “We let recipients decide if they want it.”
In a trial of the service, 400 customers from eight small Internet service providers were offered Vanquish for free. Vanquish blocked spam cold, but users also experienced installation problems and delays in checking e-mail. Vanquish, based outside Boston, says it has fixed the glitches for its June launch, and aims to have a lofty 35 million users by the end of the year. It expects ISPs to pay 20 to 45 cents per customer per month.
Raymond, who has started and sold two previous tech firms, figures that legitimate marketers, accustomed to paying for their messages in other media, will understand and appreciate Vanquish. As it is, private filtering systems and spam blacklists block plenty of marketers’ e-mails. Yahoo and AOL have destroyed messages between Procter & Gamble and customers who agreed to be contacted, as well as acceptance letters to Harvard University applicants.
Raymond has a good idea–other firms such as IronPort have also announced spam-bond products–but doesn’t have much money. Vanquish is burning through $38,000 a month, even with three engineers working for one-third of their usual salary. Recently Raymond had to beg his advisory board for another $75,000. |
Mad Max: Fury Road Review
About a month ago I wasn’t looking forward to this. Having not seen the previous Mel Gibson fronted movies (out of negligence, not out of some anti-Mel Gibbo campaign) there wasn’t the nostalgia and CGI’d cars smashing into each other wasn’t really what I look for in a blockbuster. Then recently I read up on the film a little; same writer as the original (not that I’ve seen them but apparently they’re good), mainly practical effects, brought in someone who interviews real life people sold into slavery AND they pissed off the ludicrous men’s rights blog Return of Kings (http://www.returnofkings.com/63036/why-you-should-not-go-see-mad-max-feminist-road). F*** it, I’m in let’s watch it. Jesus H(aroldfromneighbours) Christ that was incredible. Not often does an action film come out that is this balls to the walls committed to its craft. It kind of goes to show just how muddled and busy Blockbusters are becoming, it’s refreshing to have a film that doesn’t have 8 films attached to it that I need to see first. It starts off with a mini monologue, shows us what the world is like, then sets up the action and just goes form there and does not stop. I must reiterate, this action (pretty much) does not stop. Thank god it doesn’t stop because this is some of the best choreographed action I’ve seen in a long time, mainly based in and around decked out moving vehicles. With over 80% of stuff made up without CGI the action really pops and looks visceral, and explosions actually look like explosions. When Tom Hardy’s head is inches from the ground whilst being dragged beside a hurtling War Rig, it feels like it’s happening because….it is happening. In terms of plot it is used sparingly. There’s a big bad guy with some little bad guys, there’s Max as a drifter begrudgingly helping out Theron (who’s really more the heroine than Max, which is a great choice because she kills it) but apart from that this is a pure chase movie, but one that’s actually great at subtly building characters. Hardy communicates mainly in grunts as a closed off drifter who’s only goal is survival, but starts actually interacting with and trusting people as the film progresses and motivations become clearer. And by jove this film is beautiful in a grotesque way. Vivid colour and iconic villains as far as the eye can see. Apparently the director’s first instruction was that the film had to be colourful because he, like many of us, had grown a bit despondent with the ol’ “it’s the future so it should be grey”. It’s obvious that Miller’s work with the high octane bloodbaths that are Babe 2 and the Happy Feet series. Actually even though the villains are grotesque and the violence is visceral, the film does just enough to keep to a 15 so the squeamish among us don’t have to worry about gore, it’s more the danger and thrill that gets you going.
Nicholas Hoult is also pretty good in it, his character arch is less compelling but it’s an interesting look into how people have dealt with this apocalypse and he does have some really affecting scenes. There are some nice flourishes with the secondary female characters, and some attempt is made to differentiate between them but by and large they are there for the plot. All in all this is action at its purest with a surprising amount of heart and depth. There’s also a man playing electric guitar on a moving truck with a wall of speakers behind him. Also that guitar is a flamethrower. Rarely am I excited about new franchises but this seems to have what it takes; it's silly, it's serious, it's incredible, it’s mad. 9 out of 10. |
Papua New Guinea at the 2016 Summer Paralympics
Papua New Guinea competed at the 2016 Summer Paralympics in Rio de Janeiro, Brazil, from 7 September to 18 September 2016.
Disability classifications
Every participant at the Paralympics has their disability grouped into one of five disability categories; amputation, the condition may be congenital or sustained through injury or illness; cerebral palsy; wheelchair athletes, there is often overlap between this and other categories; visual impairment, including blindness; Les autres, any physical disability that does not fall strictly under one of the other categories, for example dwarfism or multiple sclerosis. Each Paralympic sport then has its own classifications, dependent upon the specific physical demands of competition. Events are given a code, made of numbers and letters, describing the type of event and classification of the athletes competing. Some sports, such as athletics, divide athletes by both the category and severity of their disabilities, other sports, for example swimming, group competitors from different categories together, the only separation being based on the severity of the disability.
Athletics
Men's track
Women's track
Joyleen Jeffrey was the opening ceremonies flag bearer for Papua New Guinea.
Broadcasting
No broadcaster had the rights to the Games in Papua New Guinea. The Games were available via live streaming on the International Paralympic Committee website.
See also
Papua New Guinea at the 2016 Summer Olympics
References
Category:Nations at the 2016 Summer Paralympics
2016
Category:2016 in Papua New Guinean sport |
Mucinous cystadenocarcinoma of the appendix with pseudomyxoma peritonei presenting as total uterine prolapse. A case report.
Mucinous cystadenocarcinoma of the appendix occurred with symptoms limited only to a total uterovaginal prolapse. Preoperative intravenous pyelogram and pelvic ultrasonography demonstrated the presence of a large pelvic mass. Exploratory laparotomy revealed the mass to be appendiceal adenocarcinoma, which was treated with extirpation of all the visible tumor and repair of the anatomic defect. |
Posts Tagged ‘hacking’
It’s pretty creepy that Tesco use the Clubcard scheme to send targeted mail about Tena Lady and vodka (or this that just me?). But even creepier, now it seems your points might not be safe.
Today it was revealed that internet scamps have been hacking into Clubcard accounts to steal points off unsuspecting customers. Tesco and the police are investigating, and appealing for those who have been affected to get in touch.
According to Tesco the number of customers affected is ‘significantly less than 100.’ But those who’ve been hacked have been reporting login issues, and some Clubcard members have been informed that the vouchers were spent miles away from their home. Some poor sap on the Tesco site complained:
‘We logged on this month to find that £160 of vouchers that we were hoping to use at Christmas had been stolen from our Clubcard account. It had been spent in two stores in London, miles away from where we live.’
So if you see anyone in the er… London branch of Tesco wearing a balaclava and pushing a trolley full of someone else’s Christmas presents, give them what’s known in the trade as ‘an unexpected item in the bagging area’.
Oops – if you’re a Twitter user, there’s a chance that online baddies might have hacked in to your account and nicked some of your info.
About 250,000 users of the wildly-popular social media phenomenon have been hacked in a move that has been described as ‘not the work of amateurs’ by the company’s info security lord, Bob Lord.
The plot thickens – Twitter has said that they will email anyone who they suspect has been hacked, but this in itself will give rise to a rash of phishing attempts, as other hackers try to disguise their fiendish works as Twitter emails, leading to further hackery and evil-doings.
In short, don’t click on a link in an email that asks you to change your password. Instead, head straight for the site in question yourself and do it that way. Clicking on links in emails = bad times.
Yesterday we reported on the massive security breach at Epsilon, an online marketing firm, that affected some of the world’s biggest brands. But while the Texas-based company and the majority of the businesses are US-based, we’re hearing about a lot of avid Bitterwallet readers in the UK who have been affected.
Readers Kiara and Jade received warnings from Benefit Cosmetics, while Chris had received an email from TiVo that stated his email address had been exposed – even though Chris has never had any contact with or passed his details onto TiVo.
This morning, more companies have admitted Epsilon has lost their customer data, which is predominantly used for email newsletters and marketing; reader Chris avidly informed us of another email he received today from Best Buy, saying “files containing the email addresses of some Best Buy customers were accessed without authorization.”
Meanwhile readers Simon, Damien and Katy have all heard from Hilton Worldwide – “Epsilon has stressed that the only information accessed was names and e-mail addresses.”
As we mentioned yesterday, it’s hardly the stuff of apocalypses, more a guarantee that your details will be folded into some überdatabase and result in phishing attempts and offers to make her “gush like a blowhole all night long” until the end of time.
WARNING! All unsecured HTTP sites (including Facebook, Twitter, Foursquare and loads of very popular web destinations) have an underbelly softer than a mouse’s ear.
A developer called Eric Butler has decided to expose it for us all to see with his new Firefox extension, Firesheep, which lets you essentially eavesdrop on any open Wi-Fi network and capture users’ cookies.
Butler explains: “As soon as anyone on the network visits an insecure website known to Firesheep, their name and photo will be displayed.”
All you have to do is double click in the window which shows a person’s details and you’ll be able to log into that user’s site with their credentials.
So basically, anytime you use an open Wi-Fi connection, there’s now a good good chance that someone can access some of your most private, personal information and correspondence (start deleting your dirty direct messages now, eh?).
Basically, if a site is not secure, it keeps track of you through a cookie which contains identifying information for that website. Firesheep grabs these cookies and lets you pretend to be them. Astonishing stuff really.
If you’re not particularly worried about someone mucking around with your social networking profiles, then maybe you’ll be more concerned about the fact that this extension can also work with things like Amazon and WordPress. And that’s just through the default setting. If you’re savvy enough, you can write your own plugins and start hacking away at other stuff.
Butler says that he created this unsavoury tool to expose the lack of security on the web.
“Websites have a responsibility to protect the people who depend on their services. They’ve been ignoring this responsibility for too long, and it’s time for everyone to demand a more secure web. My hope is that Firesheep will help the users win,” Butler says.
It seems there’s not much you can do to prevent sessions getting hijacked, so as a user, the lesson here is that you shouldn’t log-in on an open network (unless you use VPN) as it leaves you wide open for someone to start delving into your private data.
According to a new survey by a company that has plenty to gain from the results, businesses are potentially exposing their customers to data theft by failing to erase recorded calls containing personal data and credit card information.
The survey by Veritape, which sells business software for recording phone calls in call centres – no interest at all in the results of their own survey, then – claims just three per cent of UK call centres comply with industry guidelines; the other 97 per cent store unedited customer calls. Less than four in ten businesses were aware of the Payment Card Industry rules which state card details must not be stored once transactions have been completed.
Viritape say it is “relatively straightforward” for a hacker to data mine these call recordings, and that “successful hacking incidents are rising steadily.” Everyone else who has blindly reproduced their findings seems to agree with the assessment, even though it appears journalists have simply cut and paste the details. The Times, for example:
Oh. Right. The thing is, we’re struggling to find any notable examples of fraud committed in this way. Despite the claimed ease, we can’t find a single incident of recorded phone conversations been stolen remotely and the data within used to commit credit card fraud. The Telegraph publishes some figures, but these are generic figures that refer to “phone, internet and mail order fraud” rather than capturing data through the very specific method that the entire story rests on. We’re not saying it hasn’t happened, we’re just unsure why an increasingly popular and “relatively straightforward” method of stealing credit card information hasn’t led to several high profile news stories, besides those that appeared today repeating the claims of a survey conducted by a company with a vested interest in the outcome.
Of course it’s not acceptable for call centres to store personal data on the sly, but it’s somewhat difficult to ascertain whether this scaremongering PR exercise highlights any genuine threat to consumers. In the same way that writing your online banking passwords on a slip of paper in Urdu and hiding it under the floorboards potentially puts your finances at risk from burglars, there is a possibility your recorded phonecalls could be hacked – but the problem appears far less significant than anyone, either the company looking to line their pockets or the newspapers desperate to fill their pages, would have you believe.
UPDATED 17/10: The Times has amended their description of Veritape for the print version of the story:
Thereby proving they didn’t simply shamelessly cut and paste from the original press release. The new version of the story also now attempts to justify Veritape’s claims:
“Veritape says that “data mining” of audio recordings — when criminals hack into the recordings — is relatively straightforward and has occurred in at least one UK bank in the past 12 months.”
So despite the inference by Veritape that this is an increasingly common problem, they have one example of it occurring at one company in the whole country, in a year. That’s one incident, despite thousands of companies using call centres to deal with millions of customer transactions every day – and there’s still no detail of which company it was, when it occurred, how many customers were affected or indeed any other facts concerning the matter.
If your aim is to panic the public (to quote Veritape in the press, “this practice ought to send a shiver up the spine of card providers”) it’s pretty important to have a case study to prove your point, whether you’re the company pushing the research of the media reproducing it as news. |
TODD SEAVEY
author of Libertarianism for Beginners and writer of/speaker about many other things
Thursday, December 17, 2009
The Simpsons at 20
Lacking TV reception, I have no idea when the official anniversary show airs — and, of course, they started out as shorts on The Tracey Ullman Show — but today marks the actual twentieth anniversary of the first real, half-hour (Christmas-themed) episode of The Simpsons, explaining how they got Santa’s Little Helper from the racetrack.
Little did we know then that we’d come to value the Halloween episodes far more than the Christmas ones, but it was all revolutionary and hilarious — even though I almost stopped watching around episode 3 because I hated the “Dancing Homer” baseball episode so much (I still recall my friend Paul Taylor saying the same thing at the time, but we both stuck with it for at least several more seasons, thank goodness).
By contrast, I think my favorites have been “Homer in Space,” the Conan O’Brien-penned “Monorail” episode, and perhaps “Kamp Krusty.” Speaking of Krusty, I think the show marked an important break between the decades of American comedy dominated by a Vaudeville feel and — though Vaudeville’s influence will long resonate — an era more dominated by postmodernism and “college” humor. Alan King and Seth MacFarlane seem to belong to somewhat different worlds.
And nerds should be grateful simply for the sci-fi-like level of strangeness and randomness that The Simpsons has helped make acceptable on mainstream television — chaos of a kind that only the Marx Brothers, Monty Python, and moments of early Woody Allen had previously achieved but which now seemingly permeates not just several sitcoms but virtually every animated kids’ show, albeit in a more frenetic, more snarky, and far less creative form. By contrast with today’s toons, I recall when I could hardly believe my eyes when I stumbled across rare hip animated shows like The Tick, Ren and Stimpy, and the earlier, tragically overlooked New Adventures of Mighty Mouse (featuring such fitting yet absurd characters as Bat Bat, who drove a fleshtone “Manmobile” with gangly human feet instead of wheels).
What more can I say? Perhaps only: “Excellent.” And “D’oh!” And “I don’t believe in nothin’ no more — I’m going ta law school!” And “Batman’s a scientist.” And “I’m the one with stigmata.” And of course “Well, judging by his outlandish attire, he’s some sort of free-thinking anarchist.” And…
P.S. On a perhaps less historic TV note, you should be able to glimpse me silently sitting in the audience on tonight’s 8pm Eastern Stossel episode (on healthcare) on Fox Business Network (alas, without former NY lieutenant governor Betsy McCaughey as my companion, since she had to cancel). And at some point, you’ll see the episode about Rand in which I actually ask a (skeptical) question, then with luck future episodes in which I answer questions, and then I conquer the world.
TV is a selfish and merciless business, which is why I left it, but basically, they give away so many tickets they’re assured of a full house and then some — probably didn’t have any more by the time they heard from you. When in doubt, pick a far-future taping and they’ll probably still have tickets.
_The Simpsons_, by contrast, has no studio audience. Very few animated shows are taped live, due to the strain on the animators’ wrists.
Given two Star Wars parody episodes so far, constant use of 80s songs, and a talking dog character who’s a writer and went to Brown, I think I can safely say I am the intended audience for _Family Guy_ — and I, at least, am entertained. |
Expression of Nav1.9 channels in human dental pulp and trigeminal ganglion.
There is a higher incidence of local anesthetic failure in endodontic patients experiencing pulpal hyperalgesia. Up-regulation of Nav1.9, a voltage-gated sodium channel isoform, might play a key role in local anesthetic failure because Nav1.9 channels increase neuronal excitability and have low sensitivity to blockade by local anesthetics. Immunocytochemistry was used to examine Nav1.9 channel expression in axons of symptomatic (painful) versus asymptomatic human dental pulp and to determine Nav1.9 expression levels in neuronal somata of the human trigeminal ganglion. Nav1.9 channel immunoreactivity on pulpal axons was significantly increased in painful teeth. Nav1.9 channels were expressed in membranes and cytoplasm of human trigeminal ganglion neurons, with the highest expression in small neuronal somata. Nav1.9 expression in the trigeminal ganglion coupled with increased expression in symptomatic pulp might contribute to hypersensitivity of inflamed pulps and local anesthetic failure. Furthermore, the present study suggests that Nav1.9 channels are potential targets for novel anesthetics. |
Smith Nearing Sack Record
Aldon Smith leads the NFL with 19.5 sacks this season, the most ever by a player through 13 team games. He needs 3.5 sacks over the final three games to break the NFL single-season record.
Most sacks in season
Player
Sacks
Season
Michael Strahan
22.5
2001
Jared Allen
22.0
2011
Mark Gastineau
22.0
1984
Chris Doleman
21.0
1989
Reggie White
21.0
1987
-- ESPN Stats & Information
Chasing Brady, record:San Francisco 49ers outside linebacker Aldon Smith needs three sacks to tie the NFL's single-season record since 1982, when sacks became an official NFL stat.
While Smith will be matching up primarily against the New England Patriots' offensive tackles Sunday night, quarterback Tom Brady looks like his toughest adversary. Brady has taken 20 sacks on 517 dropbacks this season. He has held the ball three or fewer seconds on 70 percent of pass attempts. That means Smith and the 49ers' pass-rushers need to work quickly.
The 49ers have collected 24 of their 32 sacks this season after three seconds. That included all five of their sacks against New Orleans' Drew Brees, another tough-to-sack quarterback. San Francisco beat Brees thanks largely to a pair of interception returns for touchdowns. While Brady has thrown only four picks all season, he threw three of them during defeats to NFC West teams (Seattle, Arizona).
49ers scoreboard watching: The 49ers have scored at least 27 points in two of their past three games. That looks good on paper, but the offense hasn't always been functioning at optimum efficiency. Interception returns accounted for 14 of 31 points against New Orleans. Then, after a 16-13 defeat at St. Louis, the 49ers scored only six first-half points against the Miami Dolphins before pulling away to win 27-13.
New England has held its past three opponents beneath 20 points, the Patriots' best three-game stretch since 2009. The 49ers are 1-3 when failing to score 20 points.
Waiting game: Coaches generally instruct their quarterbacks to deliver the football in timely fashion. The sooner the better, sometimes. There are still times when good things come to those who wait.
TD Catches 4+ Seconds After Snap
Seattle Seahawks receiver Sidney Rice ranks tied for the NFL lead with four touchdown receptions on throws delivered at least four seconds after the snap.
Week 15 opponent Buffalo has allowed eight such touchdown passes, most in the NFL. Quarterback Russell Wilson's willingness to hold onto the ball is one key variable. One question this week is whether a foot injury will sideline Rice or limit his effectiveness. Rice has avoided concussions the past two weeks despite taking huge hits. He's unsure when he suffered the foot injury, but it has kept him from practicing.
Third-down prowess: The St. Louis Rams' Week 15 opponent, Minnesota, has surrendered first downs on 44 percent of third-down pass attempts, the highest rate in the league.
Can the Rams take advantage? Quarterback Sam Bradford has been outstanding on third down during fourth quarters and overtime. His 86.9 Total QBR in those situations ranks fifth in the NFL. Unfortunately for the Rams, Bradford ranks 35th out of 36 qualifying quarterbacks in third-down QBR during the first three quarters of games. He's at 7.6, ahead of only Arizona's recently benched John Skelton.
Ben Roethlisberger (92.2), Brady (89.6) and Aaron Rodgers (84.8) lead the NFL in third-down QBR across all quarters. Bradford ranks 29th at 20.1. He has three touchdowns, three interceptions, 16 sacks and a 54.8 completion percentage on third down this season.
Where Fitz stands:Arizona Cardinals quarterback Ryan Lindley has completed six of 30 attempts when targeting top receiver Larry Fitzgerald. That is one reason Fitzgerald ranks only fourth in receiving yardage among NFC West players this season.
Fitzgerald ranks second on his own team behind Andre Roberts even though Roberts has 42 fewer targets (126-84) and one fewer game played. |
Four key new features in Linux 3.6
Just a little more than two months after the release of version 3.5, Linux creator Linus Torvalds on Sunday unleashed the next new version of the Linux kernel. Ready for a quick rundown? Here are a few of the highlights.
1. Hybrid sleep
Offering a combination of sleep mode and hibernation, what's commonly known as “hybrid sleep” involves both copying the contents of RAM to the hard drive, as in hibernation, and then entering sleep mode. The big benefit to using this technique is that the computer can not only resume immediately, but it also won't lose any data if power is lost. |
Our van was broken into!
Yesterday, before playing our show in Milan we arrived back to our van to the horrible realization that we had been robbed. In a matter of minutes, thieves had made off with thousands of dollars worth of electronics and personal goods including passports, laptops, cash, clothing and items of sentimental value. I'm sure you can imagine our devastation having to let others down because of the actions of a few selfish people. Missing out on shows and being unable to cross borders for connecting flights home is the last thing that we would ever want to be facing, but unfortunately it is the position we are now in.
We hope that through your kindness we can recover some of the crippling losses we are facing and regain our footing to make it home.
Thank You
Read more |
package main
import (
"github.com/Mongey/terraform-provider-kafka/kafka"
"github.com/hashicorp/terraform-plugin-sdk/plugin"
)
func main() {
plugin.Serve(&plugin.ServeOpts{ProviderFunc: kafka.Provider})
}
|
The nation has paused this week from its toxic political battles to remember the kindness and gentleness of President George H.W. Bush. He was kind to Bill Clinton, who defeated him in 1992, and to Ross Perot, whose unusual entry into the presidential race that year siphoned conservative voters away from Bush and enabled Clinton to amass a majority of electoral votes with only 43 percent of the popular vote. The Bush I knew was the post-presidential one, who, by all appearances, harbored no bitterness or sense of defeat.
That was the consistent theme running through nearly all the reminiscences we have heard since he died late last week. Those comments about Bush’s character are, of course, being contrasted with the more in-your-face president we have today. To his credit, President Donald Trump has kept a low profile since Bush’s death, in all areas but one. He continues to pound away at his view that the investigation of him and his campaign by Department of Justice special counsel Robert Mueller is a hoax and a witch hunt.
Suicide Pact: The Radi...Andrew P. NapolitanoBest Price: $1.19Buy New $3.50(as of 01:45 EST - Details)To further that view, the president has dispatched his lawyer, Rudolph Giuliani, to make essentially two arguments. First is that Mueller’s work is a solution looking for a problem and that because there has been no crime, we don’t need a special counsel to investigate. This is a common refrain from criminal defense lawyers who represent public figures being investigated outside the normal DOJ channels. Giuliani’s second argument is that Mueller knows he has discovered no crime and will soon close up his shop.
I am not of the view that Mueller is on a fishing expedition or is about to go home. First, he has a few dozen defendants whom he has indicted and needs to try — even though most are Russians indicted for hacking and interfering with the 2016 election campaign and will be tried in absentia.
Second, he keeps acquiring new evidence. Last week, when Trump’s former personal lawyer Michael Cohen pleaded guilty in federal court in Manhattan to lying to Congress about Trump’s negotiations with Russian authorities during the 2016 presidential campaign to build Trump Tower Moscow, Cohen claimed he lied so as to further Trump’s political message, which has been one of zero relationships with Russian officials during the campaign.
Yet the most important words Cohen uttered were not those stated during his 10-minute guilty plea but those stated to Mueller’s FBI agents and prosecutors during the 70 hours that they interrogated him. Whatever he told them and they were able to corroborate, they caused his prison exposure to be reduced from somewhere between 15 and 60 years to six months. Such a reduction requires a substantial quid pro quo. What was it?
The Freedom Answer Boo...Andrew P. NapolitanoBest Price: $3.49Buy New $7.06(as of 01:00 EST - Details)The third reason for rejecting the belief that Mueller will soon shut down is Mueller’s declaration to a federal judge in Washington last week that Paul Manafort, Trump’s campaign manager during the time the Trump campaign had 87 communications with Russians, lied to FBI agents in defiance of his commitment to be truthful to them made during his guilty plea in federal court in September. Mueller will no doubt seek to indict Manafort for each of those lies and then try him — a trial that could not occur until mid-2019.
As if all that were not enough to dispel the Giuliani-fueled myth that Mueller will soon end his work, recall that Mueller has repeatedly expressed a desire to interrogate the president in a one-on-one interview or before one of his grand juries. Neither has occurred. Mueller has a toolbox of techniques to bring either of these about, and he has yet to employ the most potent contents.
Rudy Giuliani is a very talented lawyer. He has assumed two roles for his most famous client — as legal strategist and as cheerleader. As a legal strategist, he brings a wealth of experience in federal criminal procedure, but he has no serious experience defending a person accused by the feds — hence his morphing into the cheerleading role, in which he has candidly acknowledged to friends that his goal is not to dissuade the special counsel from pursuing his client but to influence public opinion so that if an indictment or impeachment of Trump were to come down, it would generally be unacceptable to the public.
It Is Dangerous to Be ...Andrew P. NapolitanoBest Price: $1.01Buy New $5.35(as of 03:45 EST - Details)Yet the more he cheerleads the more he undercuts his reputation in the legal, judicial and law enforcement communities. That’s because when he was the U.S. attorney in Manhattan, he excelled at utilizing the most extreme and aggressive prosecutorial techniques that the courts permitted — the very ones he is now attacking Mueller for using.
In the 1980s, Giuliani dispatched FBI agents to arrest corporate chieftains with television crews in tow. He burst into courtrooms, interrupting trials, to serve lawyers with subpoenas while they were trying other cases. He even wired a 10-year-old girl with a tape recorder and tutored her to entrap her mother in a drug case. He once arrested every person who was in New York’s Washington Square Park on a weekday afternoon during a drug sweep — innocent and guilty alike. He got away with it.
Federal criminal prosecution is not beanbag. The courts have ruled many times that prosecutors, FBI agents and police may lie, cheat, threaten, intimidate, coerce and deceive to extract cooperation and obtain evidence from witnesses. This is the dark side of the criminal justice system. It requires a strong stomach. It can be used against even the president.
Yet those untried absent Russians — the ones scooped up in Mueller’s witch hunt — were punished without trial. They were barred from using U.S. financial institutions by President Trump in retaliation for their alleged interference in the 2016 election. A witch hunt for me, but not for thee. |
Apple CEO Tim Cook today sent out a memo to all employees ahead of the Apple Watch’s retail try-on kickoff this Friday. Cook thanks employees who have worked on the Apple Watch by saying, “congratulations to everyone who has worked so hard for years to help this product reach our customers.” Cook also prepares the company’s retail division by noting that try-ons will begin in over 400 Apple Stores on Friday ahead of the official Friday, April 24th launch…
Likely to the delight of Apple employees, Cook also announced major Apple Watch discounts for all employees: 50% off the aluminum sport and stainless steel models and $550 off of the gold Edition variations. By comparison, the iPad was not immediately offered at discount for employees, while the original iPhone was provided for free to a large percentage of the company. The special pricing for employees lasts for 90 days, starting on Friday, which is when general Apple Watch pre-orders begin. Commenting on the reduced price, Cook told employees that “we want you to share in that experience right alongside [customers].”
Cook also told employees that “more than one thousand apps were submitted in just four days last week when the App Store started accepting them, and the rate of submissions has only been climbing since then.” Apple started accepting Apple Watch app submissions last week. Apple has already previewed several Apple Watch applications on its website and during the March Apple Watch keynote presentation, which will be available to download via the Apple Watch Companion app.
The full memo from Cook to employees can be read below:
Team, The day we’ve all been waiting for is almost here: Apple Watch is ready to ship. Our retail stores are training for a whole new way to engage customers and help them experience Apple’s most personal product yet. On Friday, in over four hundred stores across four continents, we’ll open our doors to people who want to try on Apple Watch for the first time and start deciding which one is right for them. Tens of millions of people have seen our keynotes and demonstration videos about the watch, and there’s much more to come. Some of the most innovative developers in the world are working on new experiences designed specifically for Apple Watch. More than one thousand apps were submitted in just four days last week when the App Store started accepting them, and the rate of submissions has only been climbing since then. I know that many of you have been looking forward to choosing an Apple Watch for yourselves, and we want to make it easy for you. Starting Friday, in countries where the watch is available for pre-order, a special Employee Purchase Plan will offer a 50% discount on any Apple Watch or Apple Watch Sport for your personal use. As we introduce the watch in more countries, the special pricing for employees will be offered in those countries as well. Discounts will begin at pre-order and last for 90 days after availability. AppleWeb has more details, so I invite you to check it out. Our products enrich people’s lives like no others, and we think Apple Watch is going to delight our customers in ways people can’t yet imagine. We want you to share in that experience right alongside them. Congratulations to everyone who has worked so hard for years to help this product reach our customers. And thanks in advance to the thousands of retail employees around the world who will start placing it on people’s wrists starting Friday. Tim
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Check out 9to5Mac on YouTube for more Apple news: |
I always wanted to try my hand at voicing a documentary, and River Terns was the first, followed by Kali. Both have received critical acclaim for the filmaker Amoghavarsha (Mudskipper) . However, I cannot overlook a dear friend, Naveen Raja (Vypersonic Media), who created epic pieces of music for both these films. Naveen is someone who has, along with Vinod Subramaniam, featured music/sound design in many other videos in this website collection. Let me also mention Jyolsna Balakrishnan (River Terns & My 2014 Showreel Compilation) and Ankith JK (Kali) for their exceptional editing skills in bringing these films to light.
Click on the YouTube button on the bar above and open “DOCUMENTARIES” playlist to hear&see the full documentaries |
Bartomeu Satisfied With Barca Squad
Barcelona president Josep Maria Bartomeu insists he is pleased with the club’s squad despite being linked with midfielder Paul Pogba. The Manchester United man continues to be linked with a move away from Old Trafford just months after he helped France win the World Cup in Russia.
Pogba scored during United’s 2-1 win over Leicester in the Premier League opener last week but he admits he cannot express his true feelings about his current situation.
Barca have already signed Arturo Vidal and Arthur and Bartomeu insists the current squad is still good enough to challenge for honours.
He told reporters: “As you all know, the transfer window shuts on August 31 and we’re keeping an eye on the market, but there’s no immediate need to sign anyone.
“We’re satisfied with our business in this window, both with the arrivals and departures, and I want to thank the people who are often forgotten about: our chief executive Oscar Grau, the managing director Pep Segura, our director of football Eric Abidal and his assistant, Ramon Planes.
“We are constructing an excellent squad of players with experience, both homegrown and from elsewhere. This will help us to have success.
“We have brought in young players like [Clement] Lenglet, Arthur and Malcom, who’ll quickly adapt to the way of playing football here. As for Vidal, he is a player with experience, quality and character, who’ll provide balance for the team.” |
NASFAA Advocacy
We are regularly engaged in advocacy, public policy and research to support our mission: promoting programs that remove financial barriers and ensure student access to postsecondary education. Together, the tools of advocacy, policy, and research allow us to respond effectively to pending legislation, provide ideas for new legislative and policy proposals, and to promote policy objectives in a methodologically sound manner.
We encourage NASFAA members to take action in support of the federal student aid programs and provide tools and resources to support federal advocacy:
The NASFAA Legislative Tracker provides student financial aid administrators with a comprehensive look at legislation introduced in the U.S. House of Representatives and in the U.S. Senate during this session of Congress. |
Soy based diets don't cause the cancer, it exacerbates certain types of breast cancer. So if you have that kind of breast cancer, you should avoid soy products because of the amounts of estrogen can make the cancer worse. Like I said though, it does not cause it. So if you don't have the cancer, or no family history of breast cancer, you should be ok eating soy.
I use extra firm all the time - regardless of what the recipe calls for. I just like the consistency more.
I believe in myself, I am a strong woman. I will reach my goals, NOTHING & NOBODY will hold me down. I will live my life with integrity and intention. I will set a good example for my daughters and my son. I will be a woman that makes my grand children proud when they look at pictures of me long after I've left this earth.
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Surface plasmon resonance based spectrophotometric determination of medicinally important thiol compounds using unmodified silver nanoparticles.
The determination of thiol based biological molecules and drugs, such as cysteine (Cys) (I), α-lipoic acid (II), and sodium 2-sulfanylethane sulphonate (Mesna (III)) in human plasma are becoming progressively more important due to the growing body of knowledge about their essential role in numerous biological pathways. Herein we demonstrate a sensitive colorimetric sensor for the determination of medicinally important thiol drugs based on aggregation of the citrate capped silver nanoparticles (Ag NPs). This approach exploited the high affinity of thiols towards the Ag NPs surface which could tempt replacement of the citrate shell by the thiolate shell of target molecules, resulting in aggregation of the NPs through intermolecular electrostatic interaction or hydrogen-bonding. Because of aggregation, the plasmon band at around 400nm decreases gradually, along with the appearance of a new band connoting a red shift. The calibration curves are derived from the intensity ratios of A530/A400, which display a linear relation in the range of 1μM-150μM, 5μM-200μM and 10μM-130μM, respectively. The obtained detection limits (3σ) were found to be 1.5μM, 5.6μM and 10.2μM for compound I-III, respectively. The proposed method has been successfully applied for the detection of thiol compounds in real samples. |
Today we’re urging locals to back a fund-raising drive for a Pendle family who are at the bedside of a little fighter battling meningitis.
Identical twin Thomas Procter-Whitham (3) is currently at Alder Hey Children’s Hospital, Liverpool, where he is being treated for meningococcal septicaemia.
Two, three times we were told he wasn’t going to make it and to expect the worst
Dad Adam
The tot has had to have his left leg amputated above the knee, and his brave parents Zoe Procter and Adam Whitham have been told more than once to expect the worst.
Now, the pair, who are also parents to George (3) and Braxton (5), have shared their heart-wrenching story, while thanking the local community for their overwhelming support.
Zoe, of Sheridan Road, Laneshaw Bridge, described how, in less than a week, her son went from having a slight temperature and cough, to being on the brink of death.
Having tried Calpol and Neurofen, and having rung the doctors, Zoe took matters into her own hands and decided to get Thomas to hospital.
Now, along with Adam, she is urging other parents to always trust their instinct as her journey went from a precaution to nightmare.
About two-thirds of the way to the hospital, Thomas began making a strange sound, and when Zoe looked in the mirror she noticed his eyes “had gone”.
The care worker, who is staying at Ronald McDonald House, said: “I was just screaming - I had to carry on to get to the hospital but I just wanted to stop.
“We got to the Urgent Care Centre at Burnley and they were just amazing. Thomas’ blood sugar levels had plummeted, he was having a hypo, and he had a seizure.”
Thomas was blue-lighted to Royal Blackburn Hospital, during which time he began to fidget. But, despite the positive sign, doctors saw a rash beginning to develop once he was at hospital and his parents were given the devastating news their son was to be treated for meningitis.
Zoe (30) said: “They came and told us his heart had stopped for four minutes and they had to revive him, and were doing everything they could. He was on the top dose of everything to keep him alive.”
Zoe and Adam were told Thomas may not survive the illness and, if he did, he may be severely brain damaged.
The youngster was taken to Alder Hey, where he was put in isolation after the virus spread to his blood.
Fire alarm engineer Adam (32), of Gisburn Road, Barrowford, said: “Two, three times we were told he wasn’t going to make it and to expect the worst.
“When they got him to Alder Hey they stabilised him, got him on all sorts of machines and there were 10 doctors for a good couple of days. Now they have taken him off the sedatives, and he is on painkillers. He has slightly woken up, and is opening his eyes but not focusing. We will make requests and he will do it, like squeezing our hands.”
At the weekend it was discovered Thomas had contracted an infection, and on Monday an MRI scan revealed Thomas had two bleeds on the brain.
Local resident Matthew Eyre will be collecting money for the family from 10am to 1pm outside Colne Market Hall on Saturday. He has been offered £100 by Azhar Iqbal if he dresses in pink. And £100 has already been raised at an event at the Old Bridge Inn, Barrowford. To make a donation visit www.gofundme.com/n1tifw |
Film-makers on film: Thomas Vinterberg
"This is going to sound a bit of an excuse," says Thomas Vinterberg, "in the sense that Stalker was groundbreaking for me, but it's a while ago that I've seen it, so I cannot give you the deep analysis of it. Is that all right?" It's not a promising start – and yet one doubts that this serious-minded young Dane (writer-director of 1998's Festen and the ambitious new romance It's All About Love, now on general release) will disgrace himself. Certainly, there's nothing glib about his choice of film. One of the greatest works by the Russian filmmaker Andrei Tarkovsky, Stalker is not only the equal of the more famous Andrei Rublev (1969), Solaris (1972) and The Mirror (1975), but also shares these films' stark beauty, thematic complexity and blunt refusal to spoonfeed its audience.
It's set near a nameless city, in an unspecified time, yet one that has seen the mysterious creation of "the Zone", a room that can make anyone's deepest wishes come true. Despite the fierce security around it, a writer and a scientist, seduced by the Zone's reputation, enlist the help of a so-called Stalker (one of the few who can approach the Zone without coming to harm) to take them there. As they near it, through a bleak maze of buildings, the tension escalates fiercely. But it's their initial journey towards the Zone, via a primitive railway, that has always most impressed Vinterberg, largely because at no point in this protracted episode do actually you see what the trio themselves are seeing. "When I first saw it in '92, at film school," he says, "I remember that trip on the trolley as something that opened my world of cinematography.
"There were many things in this scene," says Vinterberg. "One of them is obviously the use of sound, giving me the perspective that what you don't see on screen is the whole life of the film - but I'll come back to that. I believe that the audience remember that trip with the trolley as if they had been watching a huge landscape themselves, but they've only seen faces experiencing it.
"It also taught me that film is dependent on development. It can never stop. They're on a trolley, getting deeper and deeper into something. So you can have a long, long shot without anything happening, and it's still development. That mechanical way that people normally develop film - cut to this, cut to that - was washed away. For me, these essentials of filmmaking were represented in that scene without me knowing it.''
Vinterberg did, however, realise this a few years later, when he was putting Festen together. Along with fellow Dane Lars von Trier, he was co-signatory of the Dogme95 manifesto, which aimed to pare filmmaking down to its barest essentials. The tale of a family gathering that unleashes the darkest secrets, Festen was the first (and still the best) film to be made according to Dogme rules, and was an instant classic.
"What I was talking about before," says Vinterberg, "about hiding the essentials, has become my basic rule with filmmaking. If you have a person who's supposed to be afraid in a scene, you ask the actor to try to give the impression that he's on top of things. And then, through a small crack in his behaviour, you reveal what it's really about. So, what the scene is about is what you don't see.''
Festen, I suggest, demonstrates this par excellence. "Oh yes. The story turns around a dead sister that you don't see. She was more visible in the script, but the more we cut her out, the more powerful she became. I think if Tarkovsky had made too many cuts to POV [point-of-view shots] of landscape, it would have been a flat scene. And if I had used all the material I had with the dead sister in Festen, she would just have been an actress playing a part. But now she became godly, you know?"
Stalker pulls off a similar trick in that, unlike almost every other science-fiction film ever made, the sci-fi is in the script. Where, say, George Lucas and Ridley Scott have seduced us with twinkling cities and thundering spacecraft, Stalker boasts no more high-tech sophistication than a Bakelite telephone and a faulty lightbulb. It's perhaps the clearest example in Tarkovsky's work of his suspicion of any surface sheen that might have titillated audiences – and might have earned him a lucrative, Hollywood-style career.
"Tarkovsky totally ignores that," says Vinterberg. "He's not a prostitute, he doesn't give a shit - and I adore him for doing that. 'I'm not going to follow you,' he's saying. 'You have to follow me.' And he invites you to think: what does it mean to go to the Zone? What happened there? What is happiness? How are you looking for it? It's inspirational.
"And then," he adds, "there's this dog, completely unexplained. Why a dog? But it works, doesn't it? It's magical. I'm sure if I'd been to university doing a degree on film, I'd know a lot more about that dog. But I just like it.''
Our time is now up, and we shake hands. "I hope all that was all right," asks the director who feared he would have little of interest to say.
Thomas Vinterberg, writer, director
Born: Copenhagen 1969
Selected films: Festen (1998), It's All About Love (2004)
To order a copy of 'Stalker' on VHS (£16.99) and DVD (£22.99), both prices incl p&p, ring MovieMail on 01432 262910 or go to www.moviem.co.uk |
Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.
During embryonic development, multipotent cardiovascular progenitor cells are specified from early mesoderm. Using mouse ESCs in which gene expression can be temporally regulated, we have found that transient expression of Mesp1 dramatically accelerates and enhances multipotent cardiovascular progenitor specification through an intrinsic and cell autonomous mechanism. Genome-wide transcriptional analysis indicates that Mesp1 rapidly activates and represses a discrete set of genes, and chromatin immunoprecipitation shows that Mesp1 directly binds to regulatory DNA sequences located in the promoter of many key genes in the core cardiac transcriptional machinery, resulting in their rapid upregulation. Mesp1 also directly represses the expression of key genes regulating other early mesoderm and endoderm cell fates. Our results demonstrate that Mesp1 acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell-fate determination. |
Epidermal growth factor receptor inhibitors in non-small-cell lung cancer.
The epidermal growth factor receptor (EGFR) is a cell membrane receptor that plays a key role in cancer development and in the progression of many human malignancies, including non-small-cell lung cancer (NSCLC). EGFR-dependent signaling is involved in cancer cell proliferation, apoptosis, angiogenesis, invasion and metastasis. Targeting the EGFR is a valuable molecular approach in cancer therapy. This receptor is overexpressed in up to 80% of NSCLC cases. Thus, several molecules inhibiting this critical biologic pathway have been synthesized and tested as a single agent or in combination with other anticancer modalities in a wide of clinical trials, including reversible and irreversible small tyrosine kinase inhibitors, such as gefitinib and erlotinib, dual vascular endothelial growth factor receptor EGFR tyrosine kinase inhibitors, such as vandetanib (ZD-6474), and monoclonal antibodies, such as cetuximab, which have shown promising activity in patients with NSCLC. This review focuses on the preclinical and clinical results available with EGFR inhibitors in the treatment of NSCLC patients. |
In a manner similar to personal computers and laptops, business enterprises increasingly rely on mobile and handheld devices. Indeed, the capabilities and uses of mobile devices have moved beyond voice communications and personal information management applications to a variety of communications- and business-related functions including email, browsing, instant messaging, enterprise applications, and video applications. For example, the functionality of many mobile devices have been extended to include cellular and wireless local area network (WLAN) communications interfaces, as well as virtual private network (VPN) and other client applications. Furthermore, mobile devices used in enterprises may also include enterprise applications used by employees in the field or otherwise.
Deployment, management and configuration of mobile and handheld devices in enterprise environments, however, present certain challenges. For example, the vast and constantly changing variety of mobile device types, functions and capabilities presents challenges to configuration, provisioning and troubleshooting. Moreover, enterprise mobile expenses are one of the fastest growing enterprise expenditures, and as such, enterprises are paying more attention to their bills from network service providers. |
It’s almost winter here in Brownington, Vermont, and you’re probably already planning your next ski or snowshoeing trip. And although this may seem like the perfect time of year to poke fun at out-of-state people for their inability to drive in snowy or icy conditions, usually, it’s best to focus on our own driving to ensure we’re fully equipped to take on the weather, no matter how bad it gets. Here at B & B Towing and Recovery, safety is a top priority for us, especially around the holiday season. In this blog, we’re going to take a look at a few tips for safe driving this winter.
Replace Your Tires
Depending on the type of tires you have, they should last between 25,000 and 50,000 miles. However, when you get them replaced will depend heavily on how well they’re maintained and the road conditions you drive on. Although you can take your car into an auto mechanic shop to have them inspected, it’s pretty easy to tell on your own whether they need replacing or not. Look at the tread wear bars, the little rubber bridges in the grooves between the ridges. If the tread pattern is level with these bars, you should look into getting tires replaced. Right before winter is the perfect time to get those tires replaced.
Beware of Black Ice
Black ice is something that can take even the most experienced drivers by surprise. Although it may be obvious when there’s snow, slush, or ice patches on the road, black ice is never as noticeable and can often look just like water. Black ice requires a very specific set of conditions to be met in order to form which makes it even more surprising when you encounter a patch. Oftentimes, black ice forms when the weather changes rapidly. For example, if ice melts due to sunlight, the ice could refreeze when the sun goes behind the clouds and the temperature drops below freezing again. It’s unlikely black ice will form in urban areas that see a lot of traffic, but it is possible.
Always Err On The Side Of Caution
For the most part, driving in the winter is the same as driving in the summer, you just need to be extra cautious if it’s cold or there’s snow or ice on the roads. If there’s snow, ice, or slush on the road, drive well under the speed limit, and if there’s a lot of traffic, drive even slower. When you’re on the highway, be sure to stay farther behind the car in front of you and never slam on your brakes. Take corners slower than you normally would and never make any sudden lane changes.
Now is the best time of year to add your local towing company, B & B Towing and Recovery, to speed dial. Doing so will ensure that you always know who to call if your car ever breaks down or you get in an accident this winter. Stay tuned to our blogs here for more helpful driving tips. |
City Would Entertain Request for More Atlantic Yards Subsidies, Lieber Says
Deputy Mayor Robert Lieber, speaking yesterday at a Crain’s breakfast forum, was asked whether he would be open to giving more city subsidies to Forest City Ratner’s more than $4 billion Atlantic Yards development in Brooklyn. His noncommittal response:
“We have not received any kinds of requests, formally, from Forest City Ratner to date. But we’re open minded and we’ll listen, and if it makes sense, we’ll do it.” |
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Improving water security for remote villages
Created on December 3, 2013
A lack of water is the primary constraint to agricultural growth and food security for a large number of Iraq’s rural communities. So a readily-available and predictable water supply will bring a real boost to crop yields – to improve livelihoods and nutrition across many areas
HSAD is carrying out an assessment on the feasibility of building reservoirs and dams to harvest water and bring stability, increased prosperity and protection from climate change to targeted communities.
Potential locations for two small reservoirs in the Erbil area of Northern Iraq have been selected by the Ministry of Agriculture, with annual rainfall of 300-500 mm. Each reservoir has a capacity of 500,000-1,000,000m³. To fill the reservoir, a series of earth dams would be built to capture and store runoff water during the winter months (December-March) - this water will then be used for supplemental irrigation for wheat cultivation downstream during the dry spring months (March-May).
This work builds on more than a decade of expertise of ICARDA’s Integrated Water and Land Management research program, whose team has perfected approaches to assess the potential for water harvesting – even in areas where is very little water. Site selection included a range of engineering, natural resource and socio-economic criteria, covering: adequate runoff, suitable topography and geology, a nearby community practicing agriculture and needing supplemental irrigation, the willingness of the community to cooperate, and a number of specific technical issues.
The reservoir, dam, and a conveyance system would be used to supply water to farmers’ fields. The setup will be a model for multiplication in other areas, and will be used for research on managing water in reservoirs, supplemental irrigation, and socioeconomic aspects. To assess the project’s effectiveness, as well as the potential for large-scale use across Iraq, ICARDA has started a collaborative research program on water and land with the Ministry of Agriculture and the Ministry of Agriculture and Water Resources in Iraq’s Kurdistan region.
Enticing farmers back
Having experienced significant out-migration throughout the past two decades, the water harvesting scheme aims to entice the area’s farmers back by increasing the amount of available water – in an area that often suffers from chronic shortages - and making agriculture viable once more.
Prof. Faisal A. Daham, Head of Dams and Water Resource Engineering at the University of Salahaddin, who acted as an advisor on the scheme and was instrumental in selecting the site, describes his hopes for the intervention: "Farmers began leaving this area 20 years ago but this project will be a reason for them to return. When farmers see there are new techniques and technologies they will take advantage, and when these interventions are cost-effective they will use them more.”
The practice of supplemental irrigation – delivering water in a planned way to crops at critical periods of in the plant’s growth cycle – has been demonstrated though ICARDA’s research with many dryland countries to bring dramatically increased wheat yields. This is also an effective and practical way to combat drought and unpredictable climate patterns.
Scaling-up
If developed, the water harvesting project would provide long-lasting benefits to the communities involved. From a strategic national perspective, this project can be seen as a proof of concept – a pilot project – for how potential water harvesting sites can be identified to provide more water and food security to hundreds of communities across the country.
There is also considerable potential to extend this scheme to other parts of Iraq’s Kurdistan region – spreading the benefits of this intervention and raising farmer incomes across much wider areas. Says Prof. Daham: “We have several sites similar to the ones we have chosen which can be exploited during the dry season. Farmers are now growing wheat and barley, but with a more significant supply of water they can also grow high-value crops such as fruit and water."
Topics
This website is made possible by the support of the American people through the United States Agency for International Development (USAID).The opinions expressed herein do not necessarily reflect the views of USAID or HSAD implementing partners. |
Myocardial and skeletal muscle aging and changes in oxidative stress in relationship to rigorous exercise training.
Cardiac and skeletal muscle are very different functional tissues, and we would expect a variation in the ROS generation, in ageing and rigorous exercise-related in both tissues. We determined TBARS, total SOD, Cu, ZnSOD and MnSOD activities, and the patterns of SOD isoenzymes in skeletal muscle and heart of male Wistar rats, young and old, in rest and after rigorous exercise. There were no differences in the levels of lipoperoxidation in aged rest animals in both tissues, but the level was increased after exhaustion. The level of SOD activities was bigger in the heart than in skeletal muscle. Total SOD and Cu, ZnSOD activities were higher in old rest animals in the skeletal muscle than in young rest rats. This change did not occur in the heart. After rigorous exercise, the level of SOD activities was increased in young rats in both tissues. However, in old exhausted rats, the activities were only elevated in the heart. Different Cu, ZnSOD isoenzyme patterns showed in relation to tissues. In the skeletal muscle in old animals, the Cu, ZnSOD isoenzyme pattern was modified. The rigorous exercise did not change this pattern. The pattern of MnSOD isoenzyme was not varied in either tissue, age nor and exercise. |
This application proposes continuation of a highly successful interdisciplinary training program in infectious diseases research that is based on the tenet that both MD and PhD postdoctoral research trainees benefit enormously from exposure to faculty and trainees from both backgrounds. The program, whose research emphasis is on the interface between human host and bacterial/viral pathogens, provides an intense mentored research experience for MD and PhD postdoctoral trainees in infectious diseases. This occurs in conjunction with an individualized curriculum of didactic courses, seminars and journal clubs designed to encourage substantive interactions between MDs and PhDs. A short- term 3-month research experience for medical students is also offered. Most faculty are drawn from 1 basic science and 2 clinical departments, as well as 2 interdisciplinary PhD programs. Collaboration among program faculty is high. Research facilities are superb. The scientific program centers around three major areas: 1) Host Defense, emphasizing innate immunity; 2) Bacterial Pathogenesis; and 3) Viral Pathogenesis. Faculty are divided into: 1) full members; and 2) associate members; on the basis of their extramural research support and their experience both as an independent investigator and research mentor. Primary research mentors come from faculty meeting the criteria for full membership. An important aspect of the 3-year research experience for MD postdoctoral trainees with minimal prior research experience is an intensive exposure to a broad spectrum of graduate level basic science courses. All postdoctoral trainees establish a Research Advisory Committee. All trainees attend a research conference, as well as a seminar/ journal club designed to encourage cross-fertilization of ideas and scientific approaches between clinical medicine and basic science. They will interact with outstanding visiting scientists, attend scientific meetings, learn scientific writing and grant preparation skills, and complete a course in research and biomedical ethics. A recruitment program for minority trainees is in place and is being further expanded. In summary, this proposal requests continuation of an ongoing training program with an excellent training record which will provide a coordinated and integrated training experience for postdoctoral MD and PhD trainees in infectious diseases research related to the microbial pathogenesis of bacterial and viral infections of humans RELEVANCE: Human suffering due to infectious diseases is widespread, both due to the constant endemic diseases and emerging infectious diseases that can reach epidemic proportions. This program is designed to train biomedical and physician biomedical scientists in the most recent advances in basic and epidemiological sciences, in order to prepare them for productive career in all aspects of Infectious Diseases research. |
Stefan Popovski-Turanjanin
Stefan Popovski-Turanjanin (; born 7 March 1993) is a Serbian professional basketball player who last played for CAB Madeira in the LPB.
References
External links
Beobasket.net Profile
FIBA.com Profile
Category:1993 births
Category:Living people
Category:ABA League players
Category:Basketball players at the 2010 Summer Youth Olympics
Category:BC Oostende players
Category:CAB Madeira players
Category:KK Jagodina players
Category:KK MZT Skopje players
Category:KK Rabotnički players
Category:Serbian expatriate basketball people in Belgium
Category:Serbian expatriate basketball people in Portugal
Category:Serbian men's basketball players
Category:Serbian men's 3x3 basketball players
Category:Serbs of North Macedonia
Category:Small forwards |
… in which the authorities investigate what happened to the Jennings’ murdered colleagues, while Elizabeth and Philip stress about the dangers to their children.
‘Cardinal’ is a nice transitional episode that continues the fallout from last week’s major events, and starts setting more things in motion. At this point, no one seems to know anything about who may have killed Emmett, Leanne, and their daughter. The Rezidentura is sending frantic cables to Moscow and having high-level, closed door meetings about the event. The FBI has no idea the poor family murdered in Old Town were super-secret Directorate S agents. Emmett’s asset, Fred, didn’t purposely or accidentally expose them and is devastated by their deaths. The Center has no information for Philip and Elizabeth.
All of which has left the Jennings in a high-alert tizzy. They are absolutely terrified that they’ve inadvertently put their children at risk, leaving Philip blaming himself and pushing Elizabeth into full-on Mama Bear mode, scanning for potential threats in every seemingly innocuous passerby or utility truck. It was very interesting to see their loyalty to The Cause already starting to fray a bit, when their kids' lives may be in danger. Philip choosing to skip a night with Martha --- even knowing she had a new recording from Gaad’s office --- after hearing the strain in Elizabeth’s voice wasn’t too surprising, of course. Nor was his self-flagellation over dragging Henry into “this,” or his acknowledgement that he did have a choice in the matter. Philip has always been shown to have far greater loyalty to his family than The Cause. It was, however, a bit surprising to see Elizabeth stop recording the signal from Moscow to hover over her children. And though she didn’t ignore the new agent’s distress call later in the hour, she first rounded up her kids, ditched any potential tails, and then took the kids to a place she perceived to be safer than the house. Protecting her family first, then getting down to the business of “beautiful revolution.”
Elizabeth tells Philip that she never really considered the danger to their children before, from enemies without or within --- I’m guessing the notion of the Center “taking care of” Paige and Henry, in the event she and Philip are killed, isn’t helping to ease her worried mind --- but now it’s completely consuming her. How long until she’s forced to really choose between duty and the welfare of her children? (Particularly with Paige making inquiries into Elizabeth’s absence. If she discovers the truth, and becomes a perceived threat to Directorate S, what will the Center do then?)
The upshot of all this “focus on the (murdered) family” is that “time-sensitive information critical to the science and technology mission” of the Motherland has gotten a bit lost in the shuffle. The drawings that Fred passed to Philip last week relate to a machine, which has a connection to some kind of propeller-driven technology, that the Soviets are very keen to read the settings on. “The plant where they’re grinding the propellers is moving. It’s the one chance to get in there and read the settings on the machine.” Oleg, the new guy posted to the Rezidentura, is pretty eager to get this intel from Arkady’s agents, but seemingly no one feels it is prudent to inform him that said agents are now dead. “My best guess is there’s something going on in there that’s more important than your very important report.” Worse, even after Fred informed Philip that they are running out of time to get access to “the machine,” it doesn’t appear that Philip has yet bothered to pass along the intelligence because he was in such a rush to get home to Elizabeth. Looks like those brilliant embedded cover identities are starting to become a bit of a liability for the Soviet cause.
Other Thoughts
So who or what is CARDINAL? At the very beginning of the episode, when Arkady was trying to track down information on what might have happened to his agents, he sent a cable to Moscow stating “Request all operational reports from CARDINAL immediate,” which I believe was the only reference to Cardinal in the episode. Is that a code name for something linked to the Center?
Nina: “You seem prone to forgetting who works for whom, Oleg Igorevich.”
Oleg: “I’m a feminist, Nina. I only work for Mother Russia.”
Henry: “You’d rather play Life than watch Raiders of the Lost Ark? Are you insane?”
Seriously. Get that girl some psychiatric help, stat!
Elizabeth: “Things can go wrong. They usually do. That’s part of the job. But we get through it. You’ll get through this.”
The walk-in, Bruce Dameran of the World Bank, is a new plot bit that will presumably turn into something more down the line. I’m mildly confused about whether Arkady instructed Nina to divulge information about the walk-in to Stan or not. Is he setting up code names for the asset and the operation with knowledge that the FBI may be on to them? Nina’s report said that her “subject” was very interested in the Resident’s activities and whereabouts, and was fairly explicit about their engagement, but it didn’t seem to specifically note that she told him about the walk-in. Merely that, “as instructed,” she told the subject that she would try to push harder for further details on the Resident’s activities, and that she believes his feelings for her are deepening. (Unless we are supposed to assume that the flashback to her telling him was also being transcribed in the report. True Detective has made me overly sensitive to potential incongruities in what we hear versus what we see.)
So was telling Stan about the walk-in “as instructed” also? Or did Nina overstep? I found her expression hard to read as she was typing and going into Arkady’s office with the report. Was she hiding something, or just disgusted by her whole situation? It has to suck being forced to foster a loving, intimate relationship with someone you loathe --- someone who murdered your friend and bald-faced lied about it! --- then having to write detailed reports about your liaisons, and then having to discuss said reports and activities with your boss. Nina is in such an awful situation. I’m back to wondering who I feel worse for: Nina or Martha?
Speaking of Martha, when she wasn’t feeling well at the beginning of the episode, I was concerned that she’d turn out to be pregnant. I was very relieved she seems to just have the flu. A baby would really complicate that already seriously messed up situation. Plus, Martha wanting a gun for protection is likely going to create enough problems in the future. “Clark. I don’t want to be a victim.” Poor, hopelessly deluded Martha.
Elizabeth: “How’re we gonna live like this?”
Philip: “We’ll get used to it. Just like we got used to everything else.”
1 comment:
All I could think about when Martha started talking about a gun was Chekov. I can see that gun playing a vital role later in the season.
I'd love an episode told from Paige's point of view. She is obviously so suspicious of her parents' activities, it would be really interesting to see what she suspects and what she already knows.
As I watched this episode and read your review, I kept thinking of the inherent tension between the Jennings' job and their children. If push came to shove, would there really be a choice to be made? I hope not. |
spin bike at home? recommendations? (Read 3515 times)
farm girl
posted: 12/11/2010 at 11:05 AM
Hi, I'm considering investing in a spin bike to use at home for cross training. Anyone have suggestionson on a brand, features, or maybe brands to avoid, etc? I haven't looked into any of this yet, just thought I'd see what the RA folks had to say first Thanks for any insight.
I know nothing about specific spin bikes, but it looks like a decent gym-quality Schwinn unit would run $1-2k+. For that money why not get a decent entry-level road bike and indoor trainer? That would give you the option to ride outdoors, too. Riding the "nowhere bike" is pretty miserable, especially if there is the option to be outdoors. Only thing more miserable is running on a treadmill. With a bike that can go outdoors you can always do high-cadence "spin" rides with real hills and fresh air and ever-changing scenery and use the trainer when there's snow and ice on the roads or during high winds. You'd also have the option to do some multi-sport races, like duathlons and tris. Spin bikes have always seemed so unnecessarily limiting.
'16 Goals:
• Do some dus...and some CX...and some tandem gravel...and some podiums...
If you already have a bike, a Cyclops trainer is the best bet. It's a small unit that attached to the rear wheel of you bike so you can turn your bike into a stationary bike. A fly wheel makes contact with your rear wheel and provides resistance. The resistance is caused by either hydrolic fluid (fluid trainers (more expensive but quieter and better road feel) or magnets (cheaper but loader).
Don't be obsessed with your desires Danny. The Zen philosopher Basha once wrote, 'A flute with no holes, is not a flute. A donut with no hole, is a Danish.'
We picked up a Lemond Revmaster bike from our gym when they were replacing theirs with the latest variants. We only paid a nominal amount for it (maybe $100) and it is rock solid and performs like new.
It seems that they don't suffer the same wear and tear as treadmills so that may be an option.
The process is the goal.
Men heap together the mistakes of their lives, and create a monster they call Destiny.
It seems that they don't suffer the same wear and tear as treadmills so that may be an option.
While my real suggestion is to investigate the road bike/trainer combo, if you absolutely know that you won't ever ride outside, a spin bike has a similar advantage over a real bike to that described regarding treadmills. Not nearly as many parts on a spin bike means less to futz with and fix.
The however to the however is that is/when it does break or get squeaky, you can't get magic help from any ol' bike shop. (though some bike shops know these things... and, really, there's not much to them to know, so the mechanically inclined can perhaps figure out the issue.)
I know nothing about specific spin bikes, but it looks like a decent gym-quality Schwinn unit would run $1-2k+. For that money why not get a decent entry-level road bike and indoor trainer? That would give you the option to ride outdoors, too. Riding the "nowhere bike" is pretty miserable, especially if there is the option to be outdoors. Only thing more miserable is running on a treadmill. With a bike that can go outdoors you can always do high-cadence "spin" rides with real hills and fresh air and ever-changing scenery and use the trainer when there's snow and ice on the roads or during high winds. You'd also have the option to do some multi-sport races, like duathlons and tris. Spin bikes have always seemed so unnecessarily limiting.
+1
Only thing I would add is getting some workout DVD's/tapes when it's snowing outside to add a little spice to the workout. I have a Robby Ventura "Race Day" DVD that does a great job to getting my heart pumping and my blood flowing.
Only thing I would add is getting some workout DVD's/tapes when it's snowing outside to add a little spice to the workout. I have a Robby Ventura "Race Day" DVD that does a great job to getting my heart pumping and my blood flowing.
We have a few Spinervals DVDs with Coach Troy. I am skeered to use them. All the hardcore riders I know shudder when they talk about Coach Troy. I've run out of excuses not to try a Spinerval workout, though. I can't say that I am training for any running races as of this past Sunday and want to save my legs. D'oh! I've heard good things about the Robby Ventura DVDs. I may have to give one of those a try, soon. I do like watching movies or intense dramas while riding. During chase scenes in movies I will do some out-of-the-saddle intervals until my legs and lungs can't take anymore.
'16 Goals:
• Do some dus...and some CX...and some tandem gravel...and some podiums...
I've always done well with my Performance Bike brand fluid trainer and road bike. I've used a Kinetic and personally found it no better, just more spendy. I'd steer clear of magnetic resistance trainers. If you already have a bike a trainer more bang for your buck and easier storage. I've done spinning classes and enjoyed the stiffness of a good spin bike over the trainer so if you want to make that investment it's up to you but loads of serious cyclists do well with trainers.
Less intrigued by the $500 price point, though. And the hassle of removing the bike from the unit and replacing the wheel every time I want to ride outdoors. And it's supposed to be really loud. I do like that it takes up a bit less room and would be less of a danger to roaming cats, though. If they came down in price I might consider one.
'16 Goals:
• Do some dus...and some CX...and some tandem gravel...and some podiums...
Less intrigued by the $500 price point, though. And the hassle of removing the bike from the unit and replacing the wheel every time I want to ride outdoors. And it's supposed to be really loud. I do like that it takes up a bit less room and would be less of a danger to roaming cats, though. If they came down in price I might consider one.
Yeah, 500 is a bit much for a trainer. I'm sure not getting one. For me, the value was with the Performance trainer. The wheel removal and noise doesn't bug me, especially if it would give me a better "road" feel. I hadn't considered it but the cat safety thing would be a plus. Fortunately my trainer scares the crap out of my cat.
I hadn't considered it but the cat safety thing would be a plus. Fortunately my trainer scares the crap out of my cat.
Ours are surprisingly not all that phased by our trainers. Mostly because they are stupid. We have had to do some sudden rear wheel braking in the past. Now they are more afraid of getting yelled at than sliced-n-diced, so that keeps them out of the room more than anything.
'16 Goals:
• Do some dus...and some CX...and some tandem gravel...and some podiums...
We have a few Spinervals DVDs with Coach Troy. I am skeered to use them. All the hardcore riders I know shudder when they talk about Coach Troy. I've run out of excuses not to try a Spinerval workout, though. I can't say that I am training for any running races as of this past Sunday and want to save my legs. D'oh! I've heard good things about the Robby Ventura DVDs. I may have to give one of those a try, soon. I do like watching movies or intense dramas while riding. During chase scenes in movies I will do some out-of-the-saddle intervals until my legs and lungs can't take anymore.
Well.......... I have Coach Troy, too. If your hardcore friends shudder at them, than it's because they are pretty bland. B-O-R-I-N-G. Also, don't forget that that your don't HAVE to go as hard. It's pretty individual. Robby's are more intense ... but again, you get to choose how hard you make it, or use the big ring or the little ring. |
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There is a well-recognized national need for more K-12 students to pursue undergraduate education and careers in STEM, especially students from underrepresented backgrounds. The overall goal of the High-school Research Initiative (HRI) is to broaden and diversify the national STEM workforce by integrating scientific research experiences into the high school science curriculum in a way that supports students' matriculation into college and their persistence in science. HRI is a partnership between under-served high schools in central Texas and two nationally recognized STEM education programs at The University of Texas at Austin (UT): the Freshman Research Initiative (FRI) and UTeach. FRI is an ambitious program that involves 800+ freshmen and sophomores in conducting scientific research through research streams. In each stream, 40 undergraduates are mentored by a PhD-level Research Educator, a faculty Principal Investigator, a graduate teaching assistant, and undergraduate peer mentors in conducting independent research projects related to the scientific theme of the stream, such as designing DNA aptamers as biological sensors, developing software apps for clinical diagnostics, and examining changes in neural circuitry during learning and memory. Prior to joining a stream, undergraduates complete a research methods course, originally developed by UTeach to engage science and math majors in the inquiry process as part of their preparation to become secondary math and science teachers. HRI will combine FRI's model for involving students in research at scale and UTeach's inquiry curriculum and instructional approach. Specifically, HRI will involve the development, implementation, and evaluation of a yearlong, dual-enrollment, inquiry/research course, titled Research Methods (RM). The Research Methods course aligns with the emphasis on science practices in the Next Generation Science Standards, and will help schools meet the new Texas high school graduation requirements. When HRI reaches full scale, 250 students and 10 teachers will work with 10 FRI research streams each year to conduct original, publishable research. Students will develop skills in the design, conduct, interpretation, communication, and ethics of science research, and teachers and scientists will develop skills in mentoring students in research. Evaluation will provide rigorous evidence of the impact of participating in HRI on important outcomes for all participants that are linked to student persistence in science, most notably students' enrollment in college and pursuit of science majors. |
New Delhi: Congress leader and Member of Parliament from Thiruvananthapuram Shashi Tharoor on Sunday in his over 43-minute long speech at JNU campus compared the JNUSU president and sedition accused Kanhaiya Kumar to revolutionary Bhagat Singh.
Now, after the speech has gone viral on social media, Twitterati lashed out at Shashi Tharoor for the comparison.
Here are some of the tweets that have gone even more viral than Shashi Tharoor's speech:-
At the cost of repeating myself I must say @shashiTharoor IQ is lower than his shoe size ! https://t.co/wtdSc5SlJp — Paresh Rawal (@SirPareshRawal) March 21, 2016
Dear @ShashiTharoor , Bhagat Singh died to free India, while Kanhaiya is feeding his political ambitions on the freedom India gives him. FYI — The Bad Doctor (@DOCTORATLARGE) March 21, 2016
Shashi Tharoor has equated Kanhaiya Kumar to Shaheed Bhagat Singh
Time to equate Shashi Tharoor's IQ to Rahul Gandhi's — The Bad Doctor (@DOCTORATLARGE) March 21, 2016
Not surprised @ShashiTharoor compared Kanhaiya to Bhagat Singh. He probably thinks @OfficeOfRG is Einstein! — Shefali Vaidya (@ShefVaidya) March 21, 2016
Dear @ShashiTharoor, Bhagat Singh died trying to free the country. Kanhaiya Kumar is just fuelling his political ambitions. #NoComparisons — Yudhajit Dutta (@YudhajitDutta) March 21, 2016
Shashi Tharoor compares kanahiya to bhagat singh,Tharur must know he & kanahiya r not worthy even to be compared with bhagat singh slippers — Piyush Anand (@piyush2987) March 21, 2016
Shashi Tharoor whn ur comparing Bhagat Singh with Kanhaiya.
U have all the rights to Compare Ishrat Jahan with Sonia Gandhi. — Pradeep Kumar (@pradeepkm2272) March 21, 2016
What is happening to the intellectuals of India. Award returnees n Shashi tharoor like people have lost their mental balance. Shocking!!!! — MAHESH PATEL (@333_mahesh) March 21, 2016
By comparing Kanhaiya to Bhagat Singh, Shashi Tharoor trying to say that Bhagat Singh is a traitor, Will @HMOIndia look or just chaos ? — Pari Chawla (@MumbaiDiKudi) March 21, 2016
Somewhere in the afterlife Sukhdev, Rajguru are laughing their asses off trolling Bhagat Singh after Shashi Tharoor's comparison — The UnReal Times (@TheUnRealTimes) March 21, 2016
Shashi Tharoor compares kanhaiyya Kumar to Bhagat Singh.
Okay the Rahul Gandhi effect is finally showing on Tharoor too. — Amit.A (@Amit_smiling) March 21, 2016
it appears Shashi Tharoor is spending too much time with Rahul gandhi. His idiocity is infectious... — Akash Kumar (@desiRadar) March 21, 2016
Sometimes intelligent makes a fool out of himself and this is what Shashi Tharoor did in JNU by comparing Kanhaiya with Shaheed Bhagat Singh — SHISHIR (@KAPOORSHISHIR) March 21, 2016 |
Ag2S atomic switch-based 'tug of war' for decision making.
For a computing process such as making a decision, a software controlled chip of several transistors is necessary. Inspired by how a single cell amoeba decides its movements, the theoretical 'tug of war' computing model was proposed but not yet implemented in an analogue device suitable for integrated circuits. Based on this model, we now developed a new electronic element for decision making processes, which will have no need for prior programming. The devices are based on the growth and shrinkage of Ag filaments in α-Ag2+δS gap-type atomic switches. Here we present the adapted device design and the new materials. We demonstrate the basic 'tug of war' operation by IV-measurements and Scanning Electron Microscopy (SEM) observation. These devices could be the base for a CMOS-free new computer architecture. |
Even if there are active Management entitlements in the account, the system registration fails with "Error Class Code: 91 ".
Resolution
If there are no active or free Management Entitlements, then additional Management entitlements will need to be purchased to continue using activation keys.
If this issue is seen without using Activation Keys to register a system, it might be possible that there is an activation key in RHN account which is set as a "Universal Default". In this case, RHN would try to apply the default key to any system registering to RHN Classic, leading to the error. Removing the Universal Default setting of the activation key would allow the registration of systems without using a key and without purchasing more Management entitlements. To do this, follow these steps:
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Idiopathic subglottic stenosis revisited.
Idiopathic subglottic stenosis (ISS) is a rare inflammatory process of unknown cause, usually limited to the subglottic region and the first 2 tracheal rings. We performed a retrospective analysis of our experience with a series of patients with this condition. The study involved retrospective review of the records of patients with ISS. A series of criteria that included patient clinical history, laboratory tests, flexible nasolaryngoscopic examination, and biopsies were used to establish a diagnosis. Symptoms, treatment, and outcome were examined. A total of 16 patients were identified; 14 were female (87.5%), and 2 were male. The mean follow-up time was 75.5 months. Fourteen patients required surgical treatment for respiratory compromise. Nine of these cases have been controlled effectively with endoscopic laser techniques. Endoscopic management failed in 5 patients, and 2 patients underwent laryngotracheal resection and reconstruction. Mitomycin-C was used in 6 patients as an adjuvant to endoscopic laser surgery. Patients in whom endoscopic treatment failed were noted to have thicker (>1 cm) and more complex stenoses. The diagnosis of ISS is a diagnosis of exclusion. A complete workup of the patient must be performed to rule out other causes of stenosis. Endoscopic laser surgery is a valid initial approach for thinner, noncomplicated lesions. Patients with thicker, complex lesions in whom endoscopic treatment fails are best managed with laryngotracheal resection and reconstruction. However, adjuvant use of mitomycin-C may prove beneficial in the treatment of these patients. Estrogen may play a role in the pathogenesis of ISS by altering the wound healing response. |
Q:
MVC Ajax post to controller on click event
I'm trying to use ajax to post to a controller when a checkbox is clicked. It should update an existing object.
My two problems are:
I cannot successfully call the controller action method
Only the first item in a list has the click event
Hopefully someone can help out
On click event with ajax
$('#checkboxID').on('click', function () {
$.ajax({
url: '@Url.Action("Attending", "GuestBookings")',
type: 'POST',
data: JSON.stringify({
"cID": $(this).val('cID'), "eID": $(this).val('eID'), "check": $(this).is(':checked') ? 1 : 0
}),
success: function(result) {
alert("Succeeded post");
},
error: function(result) {
alert("Failed to post");
}
});
});
Controller HttpPost
[HttpPost]
[ValidateAntiForgeryToken]
public async Task<IActionResult> Attending(string cID, string eID, string check)
{
if (ModelState.IsValid)
{
var guest = await _context.Guests
.Where(g => g.CustomerId.ToString() == cID && g.EventId.ToString() == eID).FirstOrDefaultAsync();
if (check == "0")
{
guest.Attended = false;
}
else
{
guest.Attended = true;
}
try
{
_context.Update(guest);
await _context.SaveChangesAsync();
}
catch (DbUpdateConcurrencyException)
{
}
}
return Json(true);
}
Checkbox
<tbody>
@foreach (var item in Model.GuestsBooked)
{
<tr>
<td>
@Html.DisplayFor(modelItem => item.Surname)
</td>
<td>
@Html.DisplayFor(modelItem => item.FirstName)
</td>
<td>
@Html.DisplayFor(modelItem => item.Email)
</td>
<td>
@Html.CheckBoxFor(modelItem => item.Attended, new { @id = "checkboxID", @cID = item.Id, @eID = Model.Id })
</td>
<td>
@Html.ActionLink("Details", "Details", "Customers", new { id = item.Id }) |
@Html.ActionLink("Unbook", "Delete", "GuestBookings", new { id = item.Id, eventId = Model.Id }) |
</td>
</tr>
}
</tbody>
A:
I see a few issues with your code.
First of all, In your view code, you are rendering the table rows inside a loop. Inside the table rows, you are using the CheckBoxFor helper method to render and bind the checkbox from the Attended property value. But you are using the overload where you are passing an anonymous object as the html attributes and there you are passing the Id attribute value as checkboxID. This means it will render checkboxID as the Id for all the checkboxes. Id values should be unique. If you have same Id value for more than one element, that is invalid HTML. This will also cause your jQuery click event to only work for the first item from the collection (the checkbox rendered in the first table row).
Let's fix this first. You can use another attribute for wiring up your jQuery click event handler. For example, here I am adding an attribute called ajaxupdate instead of the Id
@Html.CheckBoxFor(modelItem => item.Attended,
new { ajaxupdate="true",
@cID = item.Id, @eID = Model.Id })
With this change, it will render the HTML markup for the checkbox element like this(some attributes are omitted for readability). The important part here is the presence of ajaxupdate attribute.
<input ajaxupdate="true" checked="checked"
cid="1" eid="2" name="item.Active" type="checkbox" >
Now to wire up the click event handler, we can use this data attribute selector.
$('[ajaxupdate="true"]').on('click', function () {
// to do : code for ajax call
});
Once we make this fix, we will find that the click event is atleast executing the event handler code. But you will notice that the ajax calls are getting a 400 bad request response from the server. This is happening because you have your action method decorated with the ValidateAntiForgeryToken attribute. When an action method is decorated with this, the framework will check the submitted request data and if it does not find a valid anti forgery token, it will be considered a bad request and a 400 response will be sent back.
To fix this problem, you can explicitly read the value of __RequestVerificationToken hidden input (Generated by the @Html.AntiForgeryToken() method call in your view) and send that in your ajax request headers.
var t = $("input[name='__RequestVerificationToken']").val();
$.ajax({ url: '@Url.Action("Attending", "Home")',
type: 'POST',
headers:
{
"RequestVerificationToken": t
},
//existing code for ajax
})
Another option is to remove the ValidateAntiForgeryToken. But taking a hit on security.'
Now with the above step we must have fixed our 400 response problem. Now you probably will get a 500 Internal server error because you are getting some null reference error because your action method parameters are not properly bound with the values you expected and your LINQ query might be returning you a null object and you are trying to update Attended property value of that object without first checking whether it is a NULL object or not.
Let's first fix the client side code. Inside the click event handler of the checkbox, the this expression represents the checkbox element which was clicked. In your razor code, you are setting the cID and eID values as attributes to the element. So you should be reading those with attr method. Also you do not need to send the JSON string version. Simply pass the JavaScript object as the data property.
So the final cleaned up version of client side code would be
$(function () {
$('[ajaxupdate="true"]').on('click', function () {
var t = $("input[name='__RequestVerificationToken']").val();
var $this = $(this);
$.ajax({
url: '@Url.Action("Attending", "GuestBookings")',
type: 'POST',
headers:
{
"RequestVerificationToken": t
},
data: {
"cID": $this.attr('cID'),
"eID": $this.attr('eID'),
"check": $this.is(':checked') ? 1 : 0
},
success: function(result) {
alert("Succeeded post");
console.log(result);
},
error: function(xhr,status,errorThrown) {
alert("Failed to post");
console.log(errorThrown);
}
});
});
});
Another suggestion I have is to use the correct types on your server side code. You are using string type for your parameters and then doing a ToString() call on your numerical properties to do comparison (with the predicate in your Where clause). Instead of doing that, use the appropriate numeric type as your parameter.
public async Task<IActionResult> Attending(int cID, int eID, int check)
{
var guest = await _context.Guests
.Where(g => g.CustomerId == cID
&& g.EventId == eID)
.FirstOrDefaultAsync();
if(guest!=null)
{
guest.IsActive = check == 0;
try
{
_context.Update(guest);
await _context.SaveChangesAsync();
}
catch (Exception ex)
{
// Make sure to log the exception and not leak the ToString version to client.
return Json(new { status = false, message = ex.ToString() });
}
return Json(new { status = true, message = "Updated" });
}
return Json(new { status = false, message = "Customer not found!" });
}
In the above code, I am returning a JSON object with a status and message property back to the client. For the exception use case, I am sending the ToString() version of the exception in the message property. You should do that only if you want to see that in the client side (mostly during your development). When you ship it to production, you do not want to leak this information to the client. Instead log it.
Inside the success handler of the ajax call, you may check the status or message property as needed.
success: function(result) {
alert(result.message);
},
|
RUGBY TOWN: Familiar face back in Saturday’s dugout
Danny Clifton returned to the starting line-up against Leek Pictures by Martin Pulley
Published:08:29Friday 06 November 2015
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Valley take on Chasetown
Ex-Rugby Town manager Dave Stringer makes a speedy return to the club when he brings his new Chasetown side to Butlin Road this Saturday for an early 1pm kick-off.
Jake Healy in the air against Leek
Stringer’s five year stint at the Valley ended in May, but he was soon back in the proverbial hotseat when he replaced the outgoing Marcus Law at the Scholars a month later.
Rugby remain in 21st place in the Evostik NPL South Division despite their 1-0 home win against Leek at the weekend, but the victory has seen them close the gap on the group immediately above – with four teams (including Chasetown themselves) now within three points of Dale Belford’s outfit.
Stringer has made a mixed start at his new club, mirroring Town’s good run in the F.A.Cup this season with a Third Qualifying Round Replay exit of their own - but only slightly bettering Rugby’s poor league form, although Chasetown’s recent draw against bottom club Tividale did mean it was now four games unbeaten in the league for them.
David Kolodynski’s solitary strike against Leek saw Town extend their run without a defeat to three games though, with the club’s all-time senior record goalscorer on target for a fourth time in those three outings.
After a slow personal start to the campaign, the striker has now upped his total to twelve in twenty starts, and will be looking to add to this at the weekend against his old boss.
Following on from Saturday’s game which has an earlier start time due to the fireworks at nearby Winfield Rec later in the day, Rugby will then face Evostik NPL Premier Ilkeston for a second time this season when they visit Butlin Road for a First Round League Cup tie on Tuesday evening.
Valley put in an impressive performance to see off Gordon Strachan’s son Gavin’s side in the First Qualifying Round of the F.A.Cup back in September, and despite Strachan junior’s departure a month ago to join up with another famous footballing son Darren Ferguson at Doncaster Rovers, the Derbyshire club are still pushing for promotion on the edge of their play-off zone in 6th place.
With the postponement of the trip to Shaw Lane Aquaforce on Saturday 14th November due to the Barnsley side’s continued involvement in the F.A.Trophy, Rugby will now face another home game on that date with the rearrangement of the visit of Newcastle Town to Butlin Road.
# Midfielder Jon Adams looks set to leave the club after a short spell at the Valley. Adams signed from Hednesford ahead of the F.A.Cup tie at Brackley and has started five times in total. He could ironically still be back at Butlin Road this Saturday though, with Chasetown one of two teams to have lodged a seven day approach for the experienced non-league campaigner. |
Haryana stalker held after minor sets herself ablaze
The Yamunanagar police on Wednesday arrested a 24-year-old man on the charges of stalking a minor, who had set herself ablaze in Karnal on Monday.
Investigating officer (IO) Negraj Singh said the 16-year-old minor had alleged that Tayed Khan had been harassing and passing lewd remarks on her for the past sometime.
Khan, a resident of Bhood Kalan in Yamunanagar, was arrested from a nearby village in the district.
Singh said: “We neither received a complaint from the girl nor from her parents against the harassment. It seems that the girl had tried to commit suicide after being unable to face the repeated alleged humiliation.
The matter was brought to our knowledge only after she had set herself on fire on Monday evening and we arrested the accused within 24 hours.”
The victim, a Class-11 student and a resident of Bhood Kalan village in Yamunanagar district of Haryana, sustained 90% burns and was rushed to the Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, in a critical condition. |
Melbourne Then and Now (Compact)
Melbourne Then and Now (Compact)
The classic series from Pavilion Books, Melbourne Then and Now showcases vintage pictures of the city and compares them with the views as they look today. Melbourne has often been considered the most English of Australia's various capital cities, yet it was the only one to be founded by a native-born Australian. In 1835 John Batman sailed from Port Philip and up the Yarra River to establish his new village. By the 1850s the discovery of gold had led to a rapid expansion and the city now had the financial muscle to build grand institutional structures. Melbourne Then and Now gives a fascinating insight into the development of the city from its Victorian roots through to the twenty-first century city of towering skyscrapers, preserving many of the grand buildings from its days as Australia's most populous and prosperous city. Sites include: Flinders Street Station, Swanston Street, Princes Bridge Hotel, Melbourne Town Hall, Queens Bridge, Customs House, Grand Hotel, Flinders Lane, Elizabeth Street, Her Majesty's Theatre, The Cyclorama, Treasury Building, Rialto and Olderfleet, Federal Coffee Palace, Bourke Street, Gog and Magog, General Post Office, State Library of Victoria, Houses of Parliament, Duke of Wellington Hotel, Windsor Hotel, Captain Cook's Cottage, Royal Mint, Royal Exhibition Building, City Baths, University of Melbourne, Flemington, Victoria Docks, the MCG, Government House, Station Pier, Albert Park and Luna Park. |
Coffee Addict? We Reveal the Best Coffee Grinder
Looking for the best coffee grinder? You’ve definitely come to the right place. Below we’ve listed five coffee grinders that are all a cut above the competition. If you’re an espresso aficionado there’s no better way to brew delicious coffee than by grinding your own beans. But before we take you to our selections – which range in price from $289 to just $22 by the way – let’ ...Read the full article |
Editor’s note: What do you expect when you don’t bring justice against criminals like McCabe? Or Comey? Or Obama? Or Holder? Or Hillary? Just sayin’.
Lest we forget Andrew McCabe was a key figure in the Democrat plot to usurp a US election.
McCabe was famously fired by the FBI on March 16, 2018, after a Justice Department inspector general report found he had repeatedly misstated his involvement in a leak to The Wall Street Journal regarding an FBI investigation into the Clinton Foundation. The watchdog office referred the matter to the U.S. Attorney’s Office in Washington, which has been investigating.
Joe Concha told Fox News that “McCabe was fired by the FBI for lying at least four times, including three times under oath” and lacks the trustworthiness needed to be taken seriously as a cable news pundit.
“His credibility is non-existent,” Concha said. “He told AndersonCooper earlier this year he believed it was possible President Donald Trump is a Russian asset, an outrageous claim for someone of his former stature to make on national television just to promote a book. take our poll - story continues below Will You Be Voting In Person November 3rd?(2) Will You Be Voting In Person November 3rd?
Should the Government be Mandating Masks? * Yes No My State Is Not Allowing In Person Voting
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Comments This field is for validation purposes and should be left unchanged. Completing this poll grants you access to DC Dirty Laundry updates free of charge. You may opt out at anytime. You also agree to this site's Privacy Policy and Terms of Use. “If applying the Michael Flynn jail sentence [standard]regarding lying to the FBI, McCabe shouldn’t be going to CNN, he should be going to jail,” Concha added. “This is truly a disservice to CNN viewers, which will only further plunge the network’s credibility into a black hole.” Conservative strategist Chris Barron mocked CNN for “ranting” about former Trump administration staffers landing media jobs and then hiring McCabe “who was fired for lying” himself.
“Honestly, you can’t make this stuff up,” Barron told Fox News. “At this point, CNN would be willing to hire Baghdad Bob if he promised to criticize Trump. It’s sad to see the once-respected outlet reduced to this.”
CNN HIRES DISGRACED FORMER FBI HEAD ANDREW MCCABE
WND News Services, August 23, 2019:
(CNBC) FORMER FBI DEPUTY DIRECTOR ANDREW MCCABE, WHO BECAME ONE OF PRESIDENT DONALD TRUMP’S TOP ENEMIES WITHIN HIS OWN ADMINISTRATION, IS JOINING CNN AS A CONTRIBUTOR, A NETWORK SPOKESPERSON SAID. HIS FIRST DAY IS FRIDAY.
McCabe spent two decades in the FBI before he was fired in March 2018 by then-Attorney General Jeff Sessions just more than 24 hours before his planned retirement.
The CNN gig comes as McCabe is fighting that termination in court. Earlier this month, McCabe filed a lawsuit in U.S. District Court alleging that his removal was part of a scheme by the president to remove government employees “because they were not politically loyal to him.”
Courtesy of The Washington Standard
Article posted with permission from Pamela Geller
More CNN Lowlights: |
The driving state determination processing method is well known in that the traveling information of a vehicle, especially a change in vehicle speed and a tendency in a time period of change, is used to analyze the traveling state of the vehicle and determine the driving state of the driver (see, e.g., Patent Literature 1).
FIG. 13 illustrates the driving state determination processing device described in Patent Literature 1. The driving state determination processing device (in-vehicle device) 901 includes a vehicle speed sensor 911, a road type determination unit 912, an in-vehicle storage device 913, a traveling state determination unit 914, a determination condition setting unit 915 and a portable storage medium 916. The driving state determination processing device 901 determines the driving state of the traveling vehicle 902 and informs the driver of the traveling vehicle 902 about the determination result 917 through a sound or an image. The traveling state determination unit 914 includes a moving average calculation unit 941 and a low level of consciousness determination unit 942.
The vehicle speed sensor 911 detects the speed of the traveling vehicle 902. The road type determination unit 912 determines the type of road where the traveling vehicle 902 is running on the basis of the speed detected by the vehicle speed sensor 911, and if the type of road is targeted, the speed and acquisition time is stored in the in-vehicle storage device 913.
The traveling state determination unit 914 calculates the average speed and the acceleration within a predetermined section from the vehicle speed stored in the in-vehicle storage device 913, holds the average speed and acceleration with the acquisition time, and extracts a time point where the acceleration is reversed from the sign at the last time point. With respect to the section containing the extracted time point where the sign of the acceleration changes plus-minus-plus, the traveling state determination unit 914 determines whether the time length of the section is within a predetermined time period and whether the difference between the maximum speed and the minimum speed within the extracted section is within a predetermined range. If the result of the determination is positive, the traveling state determination unit 914 determines that the section is a single waveform section representing a low level of consciousness and outputs the determination result 917. Patent Literature 1: Unexamined Japanese Patent Application KOKAI Publication No. 2004-234418 |
John Oliver turned his attention southward on Last Week Tonight to discuss Puerto Rico. The U.S. territory is in a massive financial crisis, facing nearly $70 billion in debt, with a poverty rate of nearly 45%. “Puerto Rico is like the last Tower Records: everything’s overpriced, everyone’s being laid off, and there is still a really weird number of Ricky Martin CDs,” said Oliver.
In a somber speech, the governor of Puerto Rico stated that the debt situation was not just an election ploy, saying: “This is not politics, this is math.” That means the situation must really be serious, because, as Oliver noted, “‘This is math’ is one of the most dread-inducing sentences in the English language.”
Read More: Lin-Manuel Miranda is on TIME’s List of the World’s Most Influential People
To make matters worse, Puerto Rico has no access to bankruptcy protection due to a mysterious piece of Congressional legislation, there was a collapse of industry on the island, there are so-called vulture hedge funds circling, and there’s a Constitutional provision that requires repayment of debt before covering fundamental needs like schools and hospitals.
Puerto Rico’s debt is seemingly insurmountable, and as Oliver noted, 3.5 million Americans need relief from law suits and debt. “We have to start treating [Puerto Rico] like an island of American citizens whose fate is interwoven with ours,” said Oliver.
Of course, Puerto Rico is not without supporters trying to bring attention to its plight. Hamilton‘s Lin-Manuel Miranda, the son of Puerto Rican immigrants, even offered Congress tickets to his hit musical if they would help his home territory. As Oliver pointed out, Congress should have taken him up on it, because “it’s easier for a meerkat to get into Harvard Law School than it is to get into that show.”
To further make his point, Oliver invited Miranda to sing a rhyming plea to help the “commonwealth without a lot of wealth.”
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Contact us at letters@time.com. |
//
// Copyright 2016 Gregory Trubetskoy. All Rights Reserved.
//
// Licensed under the Apache License, Version 2.0 (the "License");
// you may not use this file except in compliance with the License.
// You may obtain a copy of the License at
//
// http://www.apache.org/licenses/LICENSE-2.0
//
// Unless required by applicable law or agreed to in writing, software
// distributed under the License is distributed on an "AS IS" BASIS,
// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
// See the License for the specific language governing permissions and
// limitations under the License.
package serde
import (
"fmt"
"time"
"github.com/tgres/tgres/rrd"
)
type DbRoundRobinArchiver interface {
rrd.RoundRobinArchiver
Id() int64
Width() int64
SlotRow(slot int64) int64
//DPsAsPGString(start, end int64) string
//Pos() int64
Seg() int64
Idx() int64
BundleId() int64
}
type DbRoundRobinArchive struct {
rrd.RoundRobinArchiver
id int64 // Id
width int64 // In the undelying storage, how many points are stored in a single (database) row.
bundleId int64 // rra bundle id
pos int64 // absolute bundle position (seg and idx can be inferred from pos)
seg int64 // segment
idx int64 // array index
}
func (rra *DbRoundRobinArchive) Id() int64 { return rra.id }
func (rra *DbRoundRobinArchive) Width() int64 { return rra.width }
func (rra *DbRoundRobinArchive) BundleId() int64 { return rra.bundleId }
func (rra *DbRoundRobinArchive) Seg() int64 { return rra.seg }
func (rra *DbRoundRobinArchive) Idx() int64 { return rra.idx }
//func (rra *DbRoundRobinArchive) Pos() int64 { return rra.pos }
func segIdxFromPosWidth(pos, width int64) (seg, idx int64) {
// Careful: pos is 1-based. but to get a proper 1-based offset
// into a segment (idx), we need to start out with a 0-based
// value, then add 1!
return (pos - 1) / width, (pos-1)%width + 1
}
func newDbRoundRobinArchive(id, width, bundleId, pos int64, spec rrd.RRASpec) (*DbRoundRobinArchive, error) {
if spec.Span == 0 {
return nil, fmt.Errorf("Invalid span: Span cannot be 0.")
}
// Steps are aligned on milliseconds, so a step of less than a
// millisecond would result in a division by zero (see rra.update())
if spec.Step < time.Millisecond {
return nil, fmt.Errorf("Invalid step: Step: %v cannot be less than 1 millisecond.", spec.Step)
}
if (spec.Span % spec.Step) != 0 {
return nil, fmt.Errorf("Invalid Step and/or Size: Size (%v) must be a multiple of Step (%v).", spec.Span, spec.Step)
}
seg, idx := segIdxFromPosWidth(pos, width)
rra := &DbRoundRobinArchive{
RoundRobinArchiver: rrd.NewRoundRobinArchive(spec),
id: id,
width: width,
bundleId: bundleId,
pos: pos,
seg: seg,
idx: idx,
}
return rra, nil
}
// SlotRow returns the row number given a slot number. This is mostly
// useful in serde implementations.
func (rra *DbRoundRobinArchive) SlotRow(slot int64) int64 {
if slot%rra.width == 0 {
return slot / rra.width
} else {
return (slot / rra.width) + 1
}
}
// // DPsAsPGString returns data points as a PostgreSQL-compatible array string
// func (rra *DbRoundRobinArchive) DPsAsPGString(start, end int64) string {
// var b bytes.Buffer
// b.WriteString("{")
// dps := rra.DPs()
// for i := start; i <= end; i++ {
// b.WriteString(strconv.FormatFloat(dps[int64(i)], 'f', -1, 64))
// if i != end {
// b.WriteString(",")
// }
// }
// b.WriteString("}")
// return b.String()
// }
func (rra *DbRoundRobinArchive) Copy() rrd.RoundRobinArchiver {
return &DbRoundRobinArchive{
RoundRobinArchiver: rra.RoundRobinArchiver.Copy(),
id: rra.id,
width: rra.width,
bundleId: rra.bundleId,
pos: rra.pos,
}
}
type rraBundleRecord struct {
id int64
stepMs int64
size int64
width int64
}
// Representation of a row in the rra table - there is not enough
// information here to create a proper DbRoundRobinArchive in it.
type rraRecord struct {
id int64
dsId int64
bundleId int64
pos int64
seg int64
idx int64
cf string
xff float32
}
type rraStateRecord struct {
bundleId int64
seg int64
latest *time.Time
durationMs *int64
value *float64
}
|
An Apollo Astronaut Posing With a Snoopy Doll
I am assuming, I'm sure incorrectly, that you will appreciate this photograph of Apollo 10 astronaut Thomas Stafford posing with a Snoopy doll.* Yes, that is Snoopy from Peanuts. I found this picture stashed away on NASAimages.org while looking for something else, and I love it. Look at the way he's holding the doll and gazing meaningfully at its snout.
The explanation for its existence, insofar as there is one, is that during Apollo 10's orbit of the moon, the Lunar Module was called "Snoopy." The character, then, became a kind of mascot for the mission, which was a practice run for Apollo 11's actual moon landing.
And here is Stafford looking considerably more hardcore after the completion of the Gemini 9 mission.
* I highly recommend searching the NASA archive with fairly general terms. Whatever you came looking for, you will find something else of interest. Like, say, a photo of an astronaut posing with a doll from a cartoon strip. |
The Liberal government will not reform the federal electoral system, despite promising to do so when elected.
And depending on where your party politics lie, that decision has been called a betrayal, a cynical display of self-serving politics, and a lesson for voters to not believe anything Prime Minister Justin Trudeau says again.
But to Kelly Blidook, an associate professor in political science at Memorial University, the problem really isn't that the government abandoned its promise, it's that it made one in the first place.
We've created a system in politics where we want promises and we also sort of want to be able to call people liars. And I think we should accept that while promises are an important part of our democracy, we're a little too fixated on establishing promises and then measuring whether they're kept or not. I think that's a simplistic way of looking at how government works and how trust works. - Kelly Blidook
Blidook says everyone — from politicians to voters to the media have a role to play — in changing what he calls a 'culture of promises'.
"The world is a changing place, there is a lot of information that parties don't necessarily have as they're making those promises, and I think as they accumulate that information we should be open to the idea that they are going to have to potentially change the pledges they have made."
While loathe to let the prime minister off the hook, Blidook says trust in politicians and government could be built if the focus was less on what promises were made and kept, and more on dialogue, debate and policy outcomes. |
Q:
Geometry problem (Iran Olympiad)
Let $\triangle ABC$ be any triangle. Suppose the angle bisector of $\angle BAC$ intersects $BC$ at $D$. Let $\Gamma$ be a circle tangent to $BC$ at $D$ and so that $A$ belongs to the circumference of $\Gamma$. If $M$ is the (second) intersection point of $AC$ and $\Gamma$, and if $BM$ intersects $\Gamma$ at $P$, then prove that $AP$ must be a median of $\triangle ABD$.
I need some help with this problem. It was taken from an Iran Math Olympiad (from 1999 I believe).
I've mainly tried proving that $BD \over JD$$=2$ (here $J$ is $AP \cap BC$), by various methods. First, using power of points and the angle bisector theorem, no success. Then I've tried some angle chasing to find some similar triangles, just to find the same relations I had found using power of points...
Finally I went full trigonometry over it, but then again I was never quite good at trigonometry anyway, so I couldn't get very far.
I would love some hints, because I'm pretty much stuck. Thanks in advance.
A:
P is not a nice point, so let's try and avoid it.
Hint: show that $JB^2=JP \times JA = JD^2$.
Hint: Show that 2 triangles are similar to prove the first.
Hint: define N in a similar manner to M
|
A novel approach to improving emergency department consultant response times.
Emergency department (ED) overcrowding is a threat to patient safety and public health. Availability of specialty consultation to the ED may contribute to overcrowding. We implemented a novel intervention using education, goal setting and real-time performance feedback to improve time to admission for patients referred to general internal medicine (GIM). Using a time-series design, we examined the effects of a quality improvement intervention on ED wait-times in an academic medical centre. The multifaceted approach included a didactic session for GIM housestaff on medicine triage principles and methods; setting a goal to have disposition decisions and, where appropriate, admission order within 4 h of consultation request; and providing personal data feedback on their performance on this metric to GIM housestaff during their rotation on the inpatient teaching service over a 1-year period. We compared time from consultation request to disposition decision and overall ED length of stay (LOS) for all patients referred to GIM during the intervention period (February 2011-February 2012) with data from the control period (January 2010-January 2011). Mean time from GIM consultation request to admission order entry decreased by 92 min (SD, 5, p<0.05) from 321min in the control period to 229 min in the intervention period. Overall ED LOS for GIM patients decreased by 59 min (SD, 14, p<0.05) for admitted patients from 1022 min in the control period to 963 min in the intervention period, and by 40 min (SD, 13, p<0.05) for all patients referred to GIM. GIM staffing and patient characteristics remained stable across the two periods. ED throughput for admitted medical patients improved with a quality improvement initiative involving education, goal setting and performance feedback. |
Introduction This tutorial will walk you through the basics of beginning to construct your very own Trespasser level. This tutorial will cover rudimentary elements of level construction, and touch briefly on each program.This is a rough draft; if you come across any error, please PM me on the TresCom boards. Please note that screen shots may differ depending on file selection.
Required Programs Here is the list of the minimal programs required to build your own level. Items denoted with an asterisk (*) are available for download free of charge from the Trespasser Community (TresCom) website: http://www.trescom.com.
• Legal versions of Trespasser
• The Trespasser Editor (TresEd) *
• GeomAdd *
• Mini Level *
To download the other required files, browse over to the TresCom website, and under “Downloads†you will find “Utilities.†From there, download TresEd and GeomAdd. The Mini Level can be found under “levels.â€
Installation Installation of TresEd, GeomAdd, and the mini level are a breeze. Go to C drive, and create a new folder called “TresEd.†Within TresEd, create another folder called “models.†This folder is where we will place the extracted models from Trespasser for use in our new level.
Extract both TresEd and GeomAdd to the “TresEd†folder. Extract mini level to the “C:\tres cd\data†folder.
Loading the levels TresEd uses the SWP uncompressed texture files when editing a level. These can only be created by the Trespasser program. So, fire up Trespasser. Once you reach the main menu screen, press [CRTL]+[SHIFT]+[Q]+[W] to bring up the level select screen. We’ll choose the Beach level to extract all of our models from. Select “be.scn,†and click okay.
Once the beach level has loaded, you can exit out back to the main screen. Repeat the procedure to once again access the level select screen, only this time select “minilev.scn.â€
You can now exit out of Trespasser all together.
TresEd Interface Cruise over to the TresEd folder, and click on TresEd.EXE to start it up. Let’s take a moment to familiarize ourselves with the interface. You will be greeted by a similar screen:
Let’s look at the toolbar:
[u]What’s a Tscript?[/u] A Trespasser Script (or Tscript, coined by Andres James) is a collection of values that are assigned to a particular object. These values can be physical (dinosaur size, weight), mental (set dinosaur anger, fear, curiosity), or can be used as triggers (Boolean, variable, actions). Tscripts are what control the dinosaurs and what occurs in the physical world.
Level editing Select the Open button. The directory will already be set. Select “be-130.swp,†and click okay. A new dialog box will open with render options. Click okay. Once the level loads, you can move about. Using the mouse, you can look around your surroundings. Your viewpoint is positioned at Anne’s, but if you move about, you will notice that Anne stays motionary. Pressing Escape [ESC] allows you to move the mouse to look about. The movement controls are set up exactly like Trespasser’s default controls.
Code:
[u]Moving Around in TresEd[/u]
Moving around in the Trespasser Editor is fairly easy. The controls are the same as the defaults in Trespasser. When you can see the mouse cursor, you are in a static mode; you can only move along the X and Y axis. But by pressing [ESC] it will open up the world to you, and you can look around like in Trespasser. By pressing [CTRL] + [1-6] you can control the speed of your view. One is the slowest, while six is like a West African Swallow.
To select an object, simply click on it with the left mouse button. After selecting it, you can drag it around by holding in the right mouse button. You can either double-click or click on the ninth icon (= looks like an open notebook) to open and edit the selected object’s Tscripts. Selecting the tenth button (= “XYZâ€) allows you to edit the objects physical characteristics: position, rotation, and scale in the Trespasser-world, as well as renaming the object. Let’s try a simple exercise. To begin, select a tree. Click on it with the left mouse button. Click on the “File†menu on the top toolbar, and select “Export selection as TPM.â€
Code:
[u]What’s a TPM?[/u] The Trespasser Model is a file format developed by Andres James and Martjin Bujis (AKA Remdul). The structure of the file handles the objects better, and is the preferred export method. Dinosaurs can only be extracted using this format.
A new dialog box will open up. Make sure that the first two check boxes are checked, and click OK. From there, you can choose the destination to save your model. Open up the “objects†folder, and click save.
Close out of TresEd. Open up GeomAdd. Click the “Import File†option.
Select which level you wish to import your file into; in this case, click on “minilev.scn.â€
Locate your file in the “objects†directory, and click import. GeomAdd is now importing the file, and running a diagnostic on the level to make sure that everything is squared away. Click on the save button when the dialog box opens up.
Exit out of GeomAdd, and fire TresEd up again.
Your newly imported object should be at the coordinates 0,0,0. To quickly go there, hit [CRTL]+[G], which will open up a new window. Enter “0†in for all the coordinates.
Your object will be in the general area. Select it.
As you probably can see, it’s most likely protruding from out from the ground, not truly on the top. This is easy to fix. To automatically adjust the object so that it is flush with the top of terrain, simply select the object, and push: [CRTL] + [D].
To move the object, simply drag it around with the mouse while depressing the right mouse button. To move the object on only one axis, simply hold in [1], [2], or [3]. Depending on how the object is oriented, it will single out with only one axis, and you can drag it along that axis by pressing the right mouse button and dragging.
For further precision, select the object and click on the tenth icon on the toolbar, the one that looks like a “xyz.†From here, the object’s location and orientation can be set.
From this dialog box, you can also adjust the scale. This will resize the object.
You should have enough information to begin to tinker around with the mini level. So go out, and start to mess around with it! It can hurt to play around.
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Northpark Town Center
Please select all of the locations in Central Perimeter you would like more information on.
Enter a Message
.
1200 Abernathy Road, Building 600
The business center in Northpark is in the desirable Perimeter area of Atlanta, occupying the 17th floor of the newest building in the complex. Offices have ceiling-to-floor glass windows with panoramic views of the surrounding area from here and the boardroom. On-site conference facilities can accommodate up to 150 people. The lobby and reception area feature marble floors and mahogany-framed, frosted glass walls. The Perimeter is a highly sought-after area in metro Atlanta, with a high number of Fortune 500 companies and medical facilities. It’s the region’s largest employer district and is home to 125 companies employing over 100 people. As well as healthcare, the major employers cover IT, automotive, and distribution. Atlanta International Airport is a 35 minute train ride away with free access from the Sandy Springs Marta Station via a pedestrian tunnel that connects to the 600 Northpark Building. |
<?php
namespace Drupal\Tests\aggregator\Unit\Plugin;
use Drupal\aggregator\Form\SettingsForm;
use Drupal\Core\Form\FormState;
use Drupal\Tests\UnitTestCase;
/**
* Tests settings configuration of individual aggregator plugins.
*
* @group aggregator
*/
class AggregatorPluginSettingsBaseTest extends UnitTestCase {
/**
* The aggregator settings form object under test.
*
* @var \Drupal\aggregator\Form\SettingsForm
*/
protected $settingsForm;
/**
* The stubbed config factory object.
*
* @var \PHPUnit_Framework_MockObject_MockBuilder
*/
protected $configFactory;
/**
* The stubbed aggregator plugin managers array.
*
* @var array
*/
protected $managers;
/**
* {@inheritdoc}
*/
protected function setUp() {
$this->configFactory = $this->getConfigFactoryStub(
[
'aggregator.settings' => [
'processors' => ['aggregator_test'],
],
'aggregator_test.settings' => [],
]
);
foreach (['fetcher', 'parser', 'processor'] as $type) {
$this->managers[$type] = $this->getMockBuilder('Drupal\aggregator\Plugin\AggregatorPluginManager')
->disableOriginalConstructor()
->getMock();
$this->managers[$type]->expects($this->once())
->method('getDefinitions')
->will($this->returnValue(['aggregator_test' => ['title' => '', 'description' => '']]));
}
$this->settingsForm = new SettingsForm(
$this->configFactory,
$this->managers['fetcher'],
$this->managers['parser'],
$this->managers['processor'],
$this->getStringTranslationStub()
);
}
/**
* Test for AggregatorPluginSettingsBase.
*
* Ensure that the settings form calls build, validate and submit methods on
* plugins that extend AggregatorPluginSettingsBase.
*/
public function testSettingsForm() {
// Emulate a form state of a submitted form.
$form_state = (new FormState())->setValues([
'dummy_length' => '',
'aggregator_allowed_html_tags' => '',
]);
$test_processor = $this->getMock(
'Drupal\aggregator_test\Plugin\aggregator\processor\TestProcessor',
['buildConfigurationForm', 'validateConfigurationForm', 'submitConfigurationForm'],
[[], 'aggregator_test', ['description' => ''], $this->configFactory]
);
$test_processor->expects($this->at(0))
->method('buildConfigurationForm')
->with($this->anything(), $form_state)
->will($this->returnArgument(0));
$test_processor->expects($this->at(1))
->method('validateConfigurationForm')
->with($this->anything(), $form_state);
$test_processor->expects($this->at(2))
->method('submitConfigurationForm')
->with($this->anything(), $form_state);
$this->managers['processor']->expects($this->once())
->method('createInstance')
->with($this->equalTo('aggregator_test'))
->will($this->returnValue($test_processor));
$form = $this->settingsForm->buildForm([], $form_state);
$this->settingsForm->validateForm($form, $form_state);
$this->settingsForm->submitForm($form, $form_state);
}
}
// @todo Delete after https://www.drupal.org/node/2278383 is in.
namespace Drupal\Core\Form;
if (!function_exists('drupal_set_message')) {
function drupal_set_message() {}
}
|
Murder charges have been filed against a 21-year-old man suspected of killing a Bellaire police officer and a man who came to his aid Christmas Eve.
Harlem Harold Lewis has been charged with capital murder and murder in the shooting deaths of Bellaire Police Corporal J.D. Norman, 53, and Terry Taylor, 66, respectively. Lewis suffered at least one gunshot wound during the altercation and remains at Memorial Hermann Hospital in critical condition.
According to a Houston Police Department press release, Norman "was working uniform patrol and was involved in a vehicle pursuit, attempting to stop a vehicle driven by suspect Lewis. The pursuit ended in the parking lot of the Maaco Auto business [at 5625 Bellaire Blvd.] when the suspect crashed his car into a trash dumpster. Cpl. Norman exited his marked patrol car and attempted to take the suspect into custody.
"The suspect pulled a gun and a struggle ensued. Mr. Taylor, a retired U.S. Army Lieutenant Colonel and owner of the Maaco paint and body shop, came outside his business and attempted to assist Cpl. Norman. At that time, suspect Lewis shot Cpl. Norman, he then exited his vehicle and shot Mr. Taylor. A responding Bellaire patrol car, with Bellaire Lieutenant W. Bledsoe and Detective D. Clawson inside, arrived on the scene. Suspect Lewis opened fire on the responding officers and the two officers returned fire.
"The suspect then fled on foot and was located and arrested at a nearby business complex. Paramedics transported Cpl. Norman to Ben Taub General Hospital where he was pronounced dead. Suspect Lewis was taken to the hospital in critical condition. Mr. Taylor was pronounced dead at the scene." |
Turkey advances west in Syria following airstrikes on Sunday morning
Turkey carried out airstrikes on Syria Sunday morning, with a reported 25 killed in and surrounding the city of Jarablus. Various reports from media sources in Turkey and Syria have reported larger casualties, majority of which were Kurdish forces.
The strikes mark the fifth day of “Operation Euphrates Shield” which began Wednesday morning when Turkish tanks invaded Syria in a large-scale ground operation, alongside Syrian rebel forces. Turkey claims its motives are to combat the Islamic State while calling on Kurdish forces to withdraw from the region.
Turkey confirmed that they sent fighter jets that bombed a “Kurdish YPG militia site”, the Turkish military claiming it was targeting “terrorists” reporting that “five buildings used by the terrorists were also destroyed.” Turkey also reported that it had gained control of five additional villages outside of Jarablus.
Turkey continues to advance its offense on Syrian soil, moving west, targeting the Syrian Democratic Forces, the vast majority of which are YPG (The Kurdish People’s Protection Unit), with Syrian rebels carrying out ground operations Sunday morning on the village of al-Amarna, south of Jarablus, which was later hit by Turkish airstrikes.
Ahead of the weekend, Turkey’s Defense Minister Fikri Isik warned Kurdish forces that “Turkey will be following, moment by moment… If this withdrawal doesn’t happen, Turkey has every right to intervene.” |
Irakly (“Ike”) Kaveladze
Irakly (“Ike”) Kaveladze is a Vice President at the Agalarov-owned Crocus Group.
He was previously scrutinized by Congress for alleged money-laundering activities, though he denied wrongdoing and no charges were ever brought. He was revealed to be one of the participants in the June 9, 2016, Trump Tower meeting. Kaveladze reportedly attended this meeting as a representative of the Agalarovs, and has claimed he was unaware of the purpose behind the meeting. Kaveladze was born in Georgia and studied in Moscow before immigrating to the U.S. in 1991, and he currently holds American citizenship. In 2000, the New York Times reported on the findings of a Congressional inquiry explaining the ease with which foreigners could hide their identities and use shell companies to launder money through American banks. This inquiry examined accounts established by Kaveladze, who had created more than 2,000 corporations in Delaware for various Russian individuals and subsequently opened bank accounts for these corporations. Citibank, one of the banks used to open these accounts, claimed that no illegal activity was found to be linked to the accounts associated with Kaveladze. More than $1.4 billion was moved to these accounts, the sources of which were unknown. Former Senator Carl Levin, who requested the initial inquiry, referred to Kaveladze as a “poster child” for using shell companies to launder money; however, Kaveladze was not charged with any crimes as a result of the inquiry, which he described as a “witch hunt.” (Photo credit: Mark Wilson / Getty Images) |
---
abstract: 'A doubly infinite set of series expansion for $1/\pi$ are reported. They follow trivially from a formal expansion for the quotient of the values taken by the gamma function for two (complex) arguments differing by an integer plus one half, obtained by an alternative computation of the Wronskian of the modified Bessel functions. The same formal expansion allows to discover also a new binomial identity.'
author:
- |
\
J. Sesma[^1]\
\
[*Departamento de Física Teórica, Facultad de Ciencias,*]{}\
[*50009, Zaragoza, Spain*]{}
title: 'A new family of series expansions for $1/\pi$ and a binomial identity'
---
[**Keywords:**]{} Pi formulas; gamma function; modified Bessel functions; Heaviside’s exponential series; binomial identities.
[**MSC\[2010\]:**]{} 05A10; 11B65; 33B15; 40A25;
Introduction
============
Series expansions for $1/\pi$ are familiar from the pioneering work of Ramanujan [@bern]. Proofs of those expansions and procedures to obtain additional ones have been given by Borwein and Borwein [@bor1; @bor2; @bor3], Chudnovsky and Chudnovsky [@chud], and Guillera [@gui1; @gui2], among others. Here we present a doubly infinite set of series expansions for $1/\pi$ that we believe are unknown. They result as particular cases of a formal expansion which we have encountered as we were dealing with an alternative procedure of computation of the Wronskian of the modified Bessel functions $I_\nu$ and $K_\nu$. On the other hand, another particular case of the same formal expansion allows to obtain an apparently new binomial identity.
Functions of a variable $z$ are considered along the paper. Since it is a merely auxiliary variable, there is no loss of generality in assuming $z$ to be positive.
To obtain the mentioned formal expansion, we use the known value of the Wronskian [@abra Eq. 9.6.15] [@nist Eq. 10.28.2] $$\mathcal{W}\{K_\nu(z),I_\nu(z)\}=1/z\,, \label{i2}$$ the asymptotic expansion [@abra Eq. 9.7.2] [@nist Eq. 10.40.2] $$K_\nu(z)\sim\frac{\pi^{1/2}}{2^{1/2}}\,e^{-z}\sum_{n=0}^\infty a_n(\nu)\,z^{-n-1/2}\,, \label{i3}$$ and the ascending series expansion [@abra Eq. 9.6.47] [@nist Eq. 10.39.5] $$I_\nu(z)=\frac{1}{2^\nu\,\Gamma(\nu+1)}\,e^{-z}\sum_{j=0}^\infty b_j(\nu)\,z^{j+\nu}\,, \label{i4}$$ with coefficients $$a_n(\nu)=\frac{(\nu+1/2)_n\,\langle\nu-1/2\rangle_n}{n!\,2^n} \qquad \textrm{and} \qquad b_j(\nu)=\frac{2^j\,(\nu+1/2)_j}{j!\,(2\nu+1)_j} \label{i5}$$ in terms of the rising and falling factorials $$\begin{aligned}
(x)_0\equiv 1\,, & \qquad & (x)_n\equiv x(x+1)(x+2)\cdots(x+n-1)\,, \label{i6} \\
\langle x\rangle_0\equiv 1\,, & \qquad & \langle x\rangle_n\equiv x(x-1)(x-2)\cdots(x-n+1)\,. \label{i7}\end{aligned}$$
We show in Sect. 2 a formal expansion for the quotient $\Gamma(\nu+1)/\Gamma(\nu+k+1/2)$ ($k$ integer) which stems from a peculiar computation of the Wronskian of the modified Bessel functions $I_\nu$ and $K_\nu$. A doubly infinite family of series for $1/\pi$ result from that expansion by taking $\nu=m$, a non-negative integer, as shown in Sect. 3. The same expansion, with $\nu=m+1/2$, allows us to obtain, in Sect. 4, a binomial identity.
A formal expansion for the quotient of two gamma functions
==========================================================
As a previous step, we recall a not very common representation of the exponential function, namely $$\exp(t)\sim \sum_{k=-\infty}^\infty\frac{t^{k+\delta}}{\Gamma(k+1+\delta)}\,, \qquad \delta\in \mathbb{C}\,, \quad |\arg(t)|<\pi\,, \label{ii1}$$ known as Heaviside’s exponential series. It was introduced by Heaviside in the second volume of his [*Electromagnetic Theory*]{} (London, 1899), as quoted by Hardy [@hard Sects. 2.11 and 2.12]. It has been discussed by Naundorf [@naun], who has applied it to find global solutions of linear differential equations of second order with two regular or irregular singular points. According to Definition 2.1 in [@naun], the symbol $\sim$ in Equation (\[ii1\]) refers to the facts that $$\begin{aligned}
\textrm{(i)} & & \sum_{k=0}^\infty \,\frac{t^{k+\delta}}{\Gamma(k+1+\delta)}\quad \textrm{is an entire function}, \nonumber \\
\textrm{(ii)} & & \sum_{k=-\infty}^{-1} \frac{t^{k+\delta}}{\Gamma(k\! +\! 1\! +\! \delta)}\; \textrm{is an asymptotic series for}\; \exp(t)-\sum_{k=0}^\infty \frac{t^{k+\delta}}{\Gamma(n\! +\! 1\! +\! \delta)} \nonumber \\
& &\hspace{0pt} \textrm{as} \quad t\to\infty \quad \textrm{in the sector} \quad |\arg(t)|<\pi\,. \nonumber\end{aligned}$$ Notice that the asymptotic (in the just explained sense) expansion in the right-hand side of (\[ii1\]) satisfies the differential equation $dy(t)/dt=y(t)$ and becomes the familiar convergent series expansion of the exponential function when $\delta$ takes any integer value.
For arbitrary $\nu\in \mathbb{C}\setminus\{-1/2, -1,-3/2, -2, \ldots\}$ and integer $k\geq 0$, the quotient $\Gamma(\nu+1)/\Gamma(\nu+k+1/2)$ admits the formal expansion $$\frac{\Gamma(\nu+1)}{\Gamma(\nu\! +\! k\! +\! 1/2)}\sim\frac{\pi^{1/2}}{2^{2\nu}}\, \sum_{n=0}^\infty\frac{(\nu\! +\! 1/2)_n\,\langle\nu\! -\! 1/2\rangle_n\,(\nu\! +\! 1/2)_{k+n}\,(k\! +\! \nu\! +\! 2n\! +\! 1/2)}{n!\,(k+n)!\,(2\nu+1)_{k+n}}\,, \label{ii2}$$
[**Proof:**]{} Let us write (\[i2\]) in the form $$z\,\mathcal{W}\{e^zK_\nu(z), e^zI_\nu(z)\}=\exp(2z)\,. \label{ii3}$$ Substitution of $K_\nu(z)$ and $I_\nu(z)$ by their respective expansions in (\[i3\]) and (\[i4\]) gives for the left-hand side of (\[ii3\]) the formal expansion $$\frac{\pi^{1/2}}{2^{\nu+1/2}\,\Gamma(\nu+1)}\, \sum_{k=-\infty}^\infty c_k(\nu)\,z^{k+\nu-1/2}\,, \label{ii4}$$ where $$c_k(\nu)\sim\sum_{n=0}^\infty a_n(\nu)\,b_{n+k}(\nu)\,(k+2n+\nu+1/2)\,, \label{ii5}$$ with $a_n(\nu)$ and $b_{n+k}(\nu)$ as given in (\[i5\]). In turn, the right-hand side of (\[ii3\]), can be represented by the Heaviside’s exponential series $$\sum_{k=-\infty}^\infty \frac{2^{k+\nu-1/2}}{\Gamma(k+\nu+1/2)}\,z^{k+\nu-1/2}\,. \label{ii6}$$ Comparison of the expansions (\[ii4\]) and (\[ii6\]) of the two sides of (\[ii3\]) allows one to write the relation $$\frac{\pi^{1/2}}{2^{\nu+1/2}\,\Gamma(\nu+1)}\;c_k(\nu)= \frac{2^{k+\nu-1/2}}{\Gamma(k+\nu+1/2)}\,. \label{ii7}$$ Simplification of this equation, after substitution of $c_k(\nu)$ by its expression as given by (\[ii5\]) and (\[i5\]), completes the proof. $\blacksquare$
[**Remark:**]{} Both infinite sequences $\{c_k(\nu)\}$ and $\{(2^{k+\nu-1/2})/\Gamma(k+\nu+1/2)\}$ obey the recurrence relation $$(k+\nu-1/2)\,y_k-2\,y_{k-1}=0\,. \label{ii8}$$ Since this is a first order difference equation, whose solution is unique up to a multiplicative constant, those sequences must be proportional. Our proposition unveils the proportionality constant, as given in (\[ii7\]). Nevertheless, the convergence of the expansion in the right-hand side of (\[ii5\]) has not been proved and (\[ii2\]) should be seen as purely formal. Numerical exploration allows to conjecture that it is an asymptotic expansion of the left-hand side, as a function of $k$, for $k\to\infty$. It seems to become useful, from the computational point of view, for $k\gtrsim 10$.
Expansions for $1/\pi$
======================
In the particular case of being $\nu=m$, a non-negative integer, it is not difficult to see that the resulting series in the right-hand side of (\[ii2\]), $$\sum_{n=0}^\infty
\frac{(m\! +\! 1/2)_n\,\langle m\! -\! 1/2\rangle_n\,(m\! +\! 1/2)_{k+n}\,(k\! +\! m\! +\! 2n\! +\! 1/2)}{n!\,(k+n)!\,(2m+1)_{k+n}}\,, \label{iii1}$$ turns out to be convergent provided $k\geq 2$. In fact, for $n>m$, the successive terms alternate in sign, decrease monotonously in absolute value, and go to 0 as $n\to\infty$ (Leibniz’s test). Therefore, one is allowed to write, for $k\geq 2$, $$\frac{\Gamma(m+1)}{\Gamma(m\! +\! k\! +\! 1/2)} = \frac{\pi^{1/2}}{2^{2m}}\, \sum_{n=0}^\infty
\frac{(m\! +\! 1/2)_n\,\langle m\! -\! 1/2\rangle_n\,(m\! +\! 1/2)_{k+n}\,(k\! +\! m\! +\! 2n\! +\! 1/2)}{n!\,(k+n)!\,(2m+1)_{k+n}}\,. \label{iii2}$$ Replacement of the gamma function by their values and multiplication of both sides of this equation by $(1/2)_{m+k}\pi^{-1/2}/m!$ leads to the family of expansions for $1/\pi$ $$\frac{1}{\pi}=\frac{(1/2)_{m+k}}{2^{2m}}\,\frac{(2m)!}{m!}\, \sum_{n=0}^\infty
\frac{(m\! +\! 1/2)_n\,\langle m\! -\! 1/2\rangle_n\,(m\! +\! 1/2)_{k+n}\,(k\! +\! m\! +\! 2n\! +\! 1/2)}{n!\,(k+n)!\,(2m+k+n)!}\,, \label{iii3}$$ with $m=0, 1, 2, \ldots$ and $k=2, 3, 4, \ldots$. In the particular case of $m=0$, the resulting sub-family is $$\frac{1}{\pi}=(1/2)_{k}\,\sum_{n=0}^\infty (-1)^n\,\left[
\frac{(1/2)_n}{n!}\right]^3\,\frac{(n\! +\! 1/2)_k\,(k\! +\! 2n\! +\! 1/2)}{\left[(n+1)_k\right]^2}\,, \quad k=2,3,4,\ldots\,, \label{iii4}$$ expansions which resemble those reported in [@weis Eqs. (119) to (122)]. Given the structure of (\[iii4\]), namely $$\frac{1}{\pi}=\sum_{n=0}^\infty (-1)^n\left[\frac{(1/2)_n}{n!}\right]^3\! f_k(n), \,\; \textrm{with} \,\; f_k(n)\equiv (1/2)_{k}\, \frac{(n\! +\! 1/2)_k\,(k\! +\! 2n\! +\! 1/2)}{\left[(n+1)_k\right]^2}\,, \label{iii5}$$ additional series expansions for $1/\pi$ of the form $$\frac{1}{\pi}=\sum_{n=0}^\infty (-1)^n\,\left[\frac{(1/2)_n}{n!}\right]^3\,g(n) \label{iii6}$$ can be written if one takes for $g(n)$ a “normalized" linear combination of several $f_k(n)$ arbitrarily chosen, $$g(n) = \frac{\sum_k\, \alpha_k\,f_k(n)}{\sum_k\, \alpha_k}\,, \label{iii7}$$ with arbitrary (even complex) coefficients $\alpha_k$.
A binomial identity
===================
All the formal expansions in Sect. 2 become convergent series or finite sums in the particular case of being $\nu=m\! +\! 1/2$, with $m\in \{0, \mathbb{N}\}$. Since $a_n(m\! +\! 1/2)=0$ for $n>m$, the sum in the right-hand side of (\[ii5\]) becomes finite. Consequently, the same is true for that in the right-hand side of (\[ii2\]), which adopts the form $$\frac{\Gamma(m+3/2)}{\Gamma(m+k+1)}=\frac{\pi^{1/2}}{2^{2m+1}}\, \sum_{n=0}^m
\frac{(m+1)_n\,\langle m\rangle_n\,(m+1)_{k+n}\,(k+m+2n+1)}{n!\,(k+n)!\,(2m+2)_{k+n}}\,. \label{iv1}$$ Writing the gamma functions and the rising and falling factorials in this equation in terms of ordinary factorials, and grouping these in binomial coefficients, one obtains the binomial identity $$\sum_{n=0}^m {m \choose n}{m+n+k \choose m}{2m+n+k \choose n+m}^{-1}\frac{m+2n+k+1}{2m+n+k+1}=1 \label{iv2}$$ for arbitrary non-negative integers $m$ and $k$. Obviously, it can be written also in the form $$\sum_{n=0}^m {m \choose n}{n+k \choose m}{m+n+k \choose n+m}^{-1}\frac{2n+k+1}{n+m+k+1}=1\,, \quad k\geq m \in \{0,\mathbb{N}\}\,. \label{iv3}$$ This identity seems to be new. We have searched for it in several specialized publications [@boya; @goul; @prud; @rior] but we have not been able to find it.
Acknowledgments {#acknowledgments .unnumbered}
===============
This work was supported by Gobierno de Aragón (Project 226223/1) and Ministerio de Ciencia e Innovación (Project MTM215-64166).
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J.M. Borwein and P.B. Borwein, More Ramanujan-type series for $1/\pi$, in [*Ramanujan Revisited: Proceedings of the Centenary Conference*]{} (Eds. G.E. Andrews, B.C. Berndt and R.A. Rank). Academic Press, New York, 1988, pp. 359–374.
J.M. Borwein and P.B. Borwein, Class number three Ramanujan-type series for $1/\pi$, J. Comput. Appl. Math. [**46**]{} (1993) 281–290.
K.N. Boyadzhiev, [*Notes on the Binomial Transform*]{}. World Scientific, Singapore, 2018.
D.V. Chudnovsky and G.V. Chudnovsky, Approximations and complex multiplication acording to Ramanujan, in [*Ramanujan Revisited: Proceedings of the Centenary Conference*]{} (Eds. G.E. Andrews, B.C. Berndt and R.A. Rank). Academic Press, New York, 1988, pp. 375–472.
H.W. Gould, [*Tables of Combinatorial Identities*]{}. Edited by Jocelyn Quaintance, 2010. Available at https://www.math.wvu.edu/$\thicksim$gould/.
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J. Guillera, Generators of some Ramanujan formulas, Ramanujan J. [**11**]{} (2006) 41–48.
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[^1]: Email: javier@unizar.es
|
**Funding Information**
This work is based upon work supported by the Office of the Saskatchewan Multiple Sclerosis Clinical Research Chair, University of Saskatchewan, the Saskatchewan Health Research Foundation (Award 4244) and the Saskatoon City Hospital Foundation, Saskatoon, Saskatchewan, Canada.
Introduction {#acn351103-sec-0005}
============
Multiple sclerosis (MS) is a demyelinating autoimmune disorder of the central nervous system (CNS) in which neurodegeneration plays a significant role in its pathogenesis. One of the key pathological features of MS is the development of demyelinated lesions or plaques in the CNS. Plaques, depending on their stage, can contain numerous immune cells, including T cells and macrophages. In addition to inflammation, lesions also show evidence of axonal injury.[^1^](#acn351103-bib-0001){ref-type="ref"} Multiple mechanisms underlying neurodegeneration in MS have been proposed, including axonal transport deficits, mitochondrial dysfunction, and autoantibodies to nonmyelin antigens. Recently, we have provided evidence from a single MS case that a novel mechanism may underlie neuronal damage in MS.[^2^](#acn351103-bib-0002){ref-type="ref"} We have shown neuronal mislocalization of the RNA‐binding protein (RBP) heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) from its homeostatic nuclear location to the cytoplasm, where it forms aggregates. Additionally, we have found that these hnRNP A1 cytoplasmic accumulations colocalize with a marker of stress granules.
RBPs are essential in maintaining RNA homeostasis within a cell and play roles in mRNA stability, function, and transport. In addition to MS, dysfunctional RBPs, including hnRNP A1 and TAR‐DNA‐binding protein‐43 (TDP‐43), have been implicated in neurological disorders such as amyotrophic lateral sclerosis (ALS), Alzheimer\'s disease, and frontotemporal dementia (FTLD).[^3^](#acn351103-bib-0003){ref-type="ref"}, [^4^](#acn351103-bib-0004){ref-type="ref"}, [^5^](#acn351103-bib-0005){ref-type="ref"}, [^6^](#acn351103-bib-0006){ref-type="ref"}, [^7^](#acn351103-bib-0007){ref-type="ref"}, [^8^](#acn351103-bib-0008){ref-type="ref"}, [^9^](#acn351103-bib-0009){ref-type="ref"} Common features of dysfunctional RBPs in these diseases include mislocalization of the RBP from its homeostatic nuclear location to the cytoplasm and the formation of protein aggregates in the cytoplasm of cells. We and others have shown that dysfunctional RBPs, including hnRNP A1 and TDP‐43, are prominent pathological features in relevant animal models of MS.[^10^](#acn351103-bib-0010){ref-type="ref"}, [^11^](#acn351103-bib-0011){ref-type="ref"} We demonstrated that TDP‐43 and hnRNP A1 mislocalization are prevalent in spinal cord neurons of animals with experimental autoimmune encephalomyelitis. Additional analyses revealed that hnRNP A1 mislocalization correlated with disease severity, CD3^+^ immune cell infiltrates, SMI‐32 staining, a marker of neurodegeneration, and neuronal cell death.[^10^](#acn351103-bib-0010){ref-type="ref"}
Given these data suggesting that dysfunctional RBP biology may contribute to neurodegeneration in a model of MS and our previous observations in human tissue, we sought to determine whether hnRNP A1 and TDP‐43 mislocalization are features of neurons in MS cortex. We have found an increased incidence of differential distribution of the RBPs hnRNP A1 and TDP‐43 in normal appearing cortical neurons from 12 MS cases as compared to controls. Specifically, we found that MS cases displayed a significantly higher proportion of neurons with nuclear depletion and cytoplasmic accumulation of hnRNP A1 and TDP‐43. Assessment of these phenotypic changes in hnRNP A1 and TDP‐43 distribution within neurons from MS cortices, as compared to controls, suggests that dysfunctional RBPs may be involved in MS pathogenesis in a manner similar to other neurological diseases.
Materials and Methods {#acn351103-sec-0006}
=====================
Cases and autopsy material {#acn351103-sec-0007}
--------------------------
Study approval was granted by the University of Saskatchewan Biomedical Research Ethics Board (Bio\#11‐217 and Bio\#17‐207). Formalin‐fixed paraffin‐embedded autopsy material from 12 MS cases and six control cases with no known neurological deficits was used (Table [1](#acn351103-tbl-0001){ref-type="table"}). Clinical details were available for many, but not all, cases.
######
Patient demographic and clinical characteristics of non‐MS controls and neuropathologically confirmed MS cases.
Sample ID Age Sex Clinical subtype Symptom onset (year) Postmortem interval (h) Diagnosis (year)
----------- ----- ----- ------------------ ---------------------- ------------------------- ------------------
NL1 26 M Control N/A N/A N/A
NL2 41 M Control N/A 16 N/A
NL3 N/A N/A Control N/A N/A N/A
NL4 76 M Control N/A N/A N/A
NL5 74 F Control N/A N/A N/A
NL12 N/A N/A Control N/A N/A N/A
MS8 48 M MS N/A N/A N/A
MS9 54 M MS N/A N/A N/A
MS10 58 M SPMS 31 N/A 1
MS11 56 F PPMS 14 N/A 7
MS12 44 M RRMS 1 N/A 1
MS13 57 F MS N/A 3 25
MS14 44 M PPMS N/A 17 15
MS15 44 F MS N/A 9 N/A
MS16 65 F MS N/A 2 N/A
MS17 55 M SPMS N/A 3 N/A
MS22 N/A F SPMS N/A N/A N/A
MS23 49 F SPMS 27 7.5 21
Clinical data, including age, sex, clinical subtype, symptom onset and diagnosis, were included for each sample, if available. The postmortem interval was also noted, if available. NL, control; MS, multiple sclerosis; M, male; F, female; SPMS, secondary progressive MS; PPMS, primary progressive MS; RRMS, relapsing remitting MS; N/A, not available/applicable.
John Wiley & Sons, Ltd
Immunohistochemistry {#acn351103-sec-0008}
--------------------
Tissue was sectioned at 5 µm and mounted onto slides before undergoing deparaffinization and rehydration through a xylene and ethanol gradient. Endogenous peroxidases were blocked using 0.2% hydrogen peroxide in methanol. Heat‐mediated antigen retrieval was performed by placing slides in 10 mmol/L Tris/Ethylenediamine tetraacetic acid (EDTA) buffer for 45 min in a steamer. Sections were blocked in 10% fetal bovine serum (FBS) in phosphate buffered saline (PBS) for 15 min before being incubated with primary antibodies diluted in the same solution overnight at 4°C. The following primary antibodies were used: rabbit anti‐TDP‐43 (Novus Biologicals, Centennial, CO) and mouse anti‐hnRNP A1 (Millipore, Burlington, MA). The next day, sections were washed and incubated with the appropriate biotinylated secondary antibody for 1 h at room temperature and then incubated in avidin peroxidase for 1 h at room temperature. Slides were developed using 3,3′‐diaminobenzidine and counterstained with hematoxylin.
Immunofluorescence {#acn351103-sec-0009}
------------------
Tissue was sectioned, deparaffinized, and subjected to antigen retrieval as above. Following antigen retrieval, slides were washed in PBS before being placed into PBS + 0.3% Triton X‐100 for 20 min at room temperature for permeabilization. Slides were washed and treated with TrueBlack (Biotium, Fremont, CA) for 2 min as per the manufacturer\'s protocol. Sections were blocked for 1 h at room temperature in 10% FBS in PBS before being incubated with primary antibody diluted in 5% FBS in PBS overnight at 4°C. The same primary antibodies were used as above. Following overnight incubations, slides were washed and incubated with donkey anti‐mouse AlexaFluor 488 and donkey anti‐rabbit AlexaFluor 594 (both from Jackson Immunoresearch, West Grove, PA) secondary antibodies diluted in 5% FBS in PBS for 1 h at room temperature. Sections were washed and further incubated with rabbit anti‐NeuN conjugated AlexaFluor 647 (Abcam, Cambridge, UK) for 1 h at room temperature before being counterstained with 4′,6‐diamidino‐2‐phenylindole (DAPI) and mounted with ProLong Gold mounting medium.
Quantitative analysis {#acn351103-sec-0010}
---------------------
A block from each control and MS case was randomly selected for quantitative analyses. Images of normal appearing cortex were taken at 40× magnification using an Olympus BX53 microscope equipped with an Olympus DP72 camera (Olympus Canada Inc., Ontario, Canada). Approximately 20 images for normal appearing cortex were acquired per case. Images were imported into ImageJ and individual neurons were assessed for the phenotype of the RBP of interest. Examiners were not blinded when assessing the images. Seven phenotypes were defined in order to assess RBP distribution in each neuron (Table [2](#acn351103-tbl-0002){ref-type="table"}, Fig. [1](#acn351103-fig-0001){ref-type="fig"}), ranging from a physiological, normal appearing phenotype (Phenotype 1: robust nuclear RBP staining, no cytoplasmic staining) to a more severe mislocalization phenotype associated with pathological RBP distribution (Phenotype 7: nuclear depletion of RBP, cytoplasmic accumulation of RBP). Groups of at least 150 neurons were counted across the acquired images for each individual case and percentages were determined by dividing the number of positive neurons for a phenotype by the total number of neurons counted. This yielded a phenotype distribution plot for each individual case representing the variation in the RBP phenotypes present.
######
RNA‐binding protein phenotype scoring system for quantification.
Phenotype no. Description
--------------- -------------------------------------------------------------------
1 Robust, nuclear RBP staining, no cytoplasmic staining
2 Robust, nuclear RBP staining, faint cytoplasmic staining
3 Robust, nuclear RBP staining, robust cytoplasmic staining
4 Faint or sparse nuclear RBP staining, no cytoplasmic staining
5 Faint or sparse nuclear RBP staining, faint cytoplasmic staining
6 Faint or sparse nuclear RBP staining, robust cytoplasmic staining
7 Nuclear depletion of RBP, cytoplasmic staining
RBP, RNA‐binding protein.
John Wiley & Sons, Ltd
{#acn351103-fig-0001}
Statistical analysis {#acn351103-sec-0011}
--------------------
Statistical analyses were performed using GraphPad Prism 5 software. For comparisons between individual phenotypes in control and MS normal appearing cortex, one‐tailed unpaired tests were used to determine differences. *P* \< 0.05 was considered statistically significant.
Results {#acn351103-sec-0012}
=======
Normal appearing cortex from MS patients exhibited differential distribution of TDP‐43 phenotypes as compared to controls {#acn351103-sec-0013}
-------------------------------------------------------------------------------------------------------------------------
Previous reports of TDP‐43 mislocalization in neurons from other neurologic diseases, demonstrated severe phenotypes where TDP‐43 shifts from being mainly nuclear to almost exclusively cytoplasmic under disease conditions.[^12^](#acn351103-bib-0012){ref-type="ref"}, [^13^](#acn351103-bib-0013){ref-type="ref"} Interestingly, in vitro experiments have described a gradient of TDP‐43 mislocalization in which TDP‐43 transitions from being exclusively nuclear to being nuclear with faint cytoplasmic staining to faintly nuclear and robustly cytoplasmic.[^8^](#acn351103-bib-0008){ref-type="ref"}, [^14^](#acn351103-bib-0014){ref-type="ref"}, [^15^](#acn351103-bib-0015){ref-type="ref"} In order to account for the varying degrees of mislocalization, we described seven neuronal RBP phenotypes to stage TDP‐43 localization in this study (Table [2](#acn351103-tbl-0002){ref-type="table"}, Fig. [1](#acn351103-fig-0001){ref-type="fig"}). Neurons from control cases (*n* = 6) predominantly exhibited phenotypes 1 and 2, accounting for approximately 80--90% of quantified neurons, characterized by robust TDP‐43 staining of the nucleus (Fig. [2B](#acn351103-fig-0002){ref-type="fig"}). Varying numbers of neurons, depending on the control case, exhibited phenotype 4, with TDP‐43 faintly staining the nucleus. In controls, no neurons were found to be phenotypes 6 or 7, where TDP‐43 exhibits a pattern of nuclear depletion and cytoplasmic mislocalization. Conversely, in normal appearing cortex of MS patients, the percentage of neurons exhibiting phenotypes 1 and 2 decreased to varying degrees across all cases but no cases exhibited more than 60% of these nuclear TDP‐43 phenotypes (Fig. [2B](#acn351103-fig-0002){ref-type="fig"}). The appearance of phenotypes 6 and 7 in normal appearing cortex neurons, in which TDP‐43 was minimal in the nucleus and accumulates within the cytoplasm, was robust in the majority of the examined MS cases. This suggests a marked shift in neuronal TDP‐43 phenotype from mostly nuclear TDP‐43 localization in controls to an increased cytoplasmic accumulation in MS cases (Fig. [2A](#acn351103-fig-0002){ref-type="fig"}). Individual TDP‐43 phenotypes were compared between control and MS cases. A significant reduction in the number of neurons exhibiting phenotypes 1, 2, and 3 was found in MS cases as compared to controls (Fig. [2C](#acn351103-fig-0002){ref-type="fig"}, *P* \< 0.0001, *P* \< 0.01, *P* \< 0.05, respectively). There was a significant increase in the number of neurons positive for phenotypes 5, 6, and 7 in MS cases as compared to controls (Fig. [2C](#acn351103-fig-0002){ref-type="fig"}, *P* \< 0.001 for all).
{ref-type="table"} and Figure [1](#acn351103-fig-0001){ref-type="fig"}. Scale bar 20μm. (B) Quantification and distribution of the seven different RBP phenotypes when examining TDP‐43 staining in neurons from cortex for each control case (*n* = 6) and MS case (*n* = 12). For analyses, images were taken from normal appearing cortex. (C) Graphical illustration of the differences between control and MS cases for each individual TDP‐43 phenotype. Data are graphed as the percentage of neurons positive for that phenotype where the denominator is the number of neurons counted in that case (150--340 neurons per case). Each circle (controls, *n* = 6) or square (MS, *n* = 12) represents a value from an individual case. Unpaired t‐test for statistical analysis. \**P* \< 0.05, \*\**P* \< 0.01, \*\*\**P* \< 0.001, \*\*\*\**P* \< 0.0001. Error bars represent standard error of mean. TDP‐43, TAR‐DNA‐binding protein‐43; RBP, RNA‐binding protein; NL, control, MS, multiple sclerosis; n.s., not significant.](ACN3-7-1214-g002){#acn351103-fig-0002}
Differential distribution of hnRNP A1 phenotypes in normal appearing cortex from MS patients {#acn351103-sec-0014}
--------------------------------------------------------------------------------------------
We previously published a single case of MS exhibiting hnRNP A1 nuclear depletion of cortical neurons.[^2^](#acn351103-bib-0002){ref-type="ref"} As with TDP‐43 distribution, hnRNP A1 may vary in its cellular distribution based on cell type and condition.[^16^](#acn351103-bib-0016){ref-type="ref"} In order to account for the gradient of hnRNP A1 distribution patterns, we used the same seven neuronal RBP phenotypes as described above to phenotypically assess hnRNP A1 localization in our study (Table [2](#acn351103-tbl-0002){ref-type="table"}, Fig. [1](#acn351103-fig-0001){ref-type="fig"}). Neurons from control cases predominantly showed phenotypes 1 and 2 of nuclear hnRNP A1 localization, accounting for approximately 50--80% of the neurons that were quantified (Fig. [3](#acn351103-fig-0003){ref-type="fig"}). However, two of the control cases displayed an increased prevalence of phenotype 3 with robust hnRNP A1 staining of both the nucleus and cytoplasm. Three control cases contained neurons which displayed less than 5% of phenotypes 4 or 5. Furthermore, no control cases were found to contain neurons exhibiting phenotypes 6 or 7 (Fig. [3](#acn351103-fig-0003){ref-type="fig"}). In the normal appearing cortex of MS patients, the presence of neurons positive for phenotypes 1 and 2 decreased (Fig. [3B](#acn351103-fig-0003){ref-type="fig"}) suggesting a reduction in nuclear hnRNP A1 localization. Furthermore, all of the MS cases examined contained hnRNP A1 phenotypes 6 and 7 in normal appearing cortex neurons, suggesting a marked shift from nuclear to cytoplasmic hnRNP A1 distribution as compared to control cases (Fig. [3C](#acn351103-fig-0003){ref-type="fig"}). Several cases robustly replicated our seminal findings of neuronal hnRNP A1 nuclear depletion (Fig. [3B](#acn351103-fig-0003){ref-type="fig"}). We further performed individual comparisons of each hnRNP A1 phenotype to determine differences between control and MS cases. MS cases displayed a significant reduction in phenotype 1 as compared to control cases (Fig. [3C](#acn351103-fig-0003){ref-type="fig"}, *P* \< 0.05). Phenotypes 2, 3, and 4 were found to not be statistically different between control and MS cases. However, MS cases contained significantly more normal appearing cortex neurons exhibiting phenotypes 5, 6, and 7 as compared to controls (Fig. [3C](#acn351103-fig-0003){ref-type="fig"}, *P* \< 0.01 for all). These data closely parallel the phenotypic distribution changes we also observed during the TDP‐43 phenotype analyses.
{ref-type="table"} and Figure [1](#acn351103-fig-0001){ref-type="fig"}. Scale bar 20μm. (B) Quantification and distribution of the seven different RBP phenotypes when examining hnRNP A1 staining neurons from cortex from each control case (*n* = 6) and MS case (*n* = 12). For analyses, images were taken from normal appearing cortex. (C) Graphical illustration of the differences between control and MS cases for each individual hnRNP A1 phenotype. Data are graphed as the percentage of neurons positive for that phenotype where the denominator is the number of neurons counted in that case (165--280 neurons per case). Each circle (controls, *n* = 6) or square (MS, *n* = 12) represents a value from an individual case. Unpaired t‐test for statistical analysis. \**P* \< 0.05, \*\**P* \< 0.01. Error bars represent standard error of mean. *NL* control, *MS* multiple sclerosis, n.s. not significant. MS, multiple sclerosis; hnRNP A1, heterogeneous nuclear ribonucleoprotein A1.](ACN3-7-1214-g003){#acn351103-fig-0003}
Mislocalization of hnRNP A1 and TDP‐43 within the same neurons in MS normal appearing cortex {#acn351103-sec-0015}
--------------------------------------------------------------------------------------------
Considering that we observed similarities in the phenotypic distribution changes between TDP‐43 and hnRNP A1 in MS cases, we performed immunofluorescence for both RBPs in a control and MS case to determine if there was colocalization of TDP‐43 and hnRNP A1 in neurons. Neurons from control normal appearing cortex demonstrated predominantly nuclear colocalization of TDP‐43 and hnRNP A1, illustrative of phenotype 1 (Fig. [4](#acn351103-fig-0004){ref-type="fig"}). In contrast with controls, MS normal appearing cortex showed decreased nuclear staining of hnRNP A1 and TDP‐43 and increased, robust cytoplasmic mislocalization within the same neuron (Fig. [4](#acn351103-fig-0004){ref-type="fig"}), some of which colocalized. Both hnRNP A1 and TDP‐43 demonstrated phenotype 6 RBP distribution within this neuron suggestive of a relationship between the two RBPs.
{#acn351103-fig-0004}
Discussion {#acn351103-sec-0016}
==========
We previously published data from a single MS case compared to a non‐MS control demonstrating nuclear depletion of hnRNP A1, an RBP important in mRNA splicing and transport.[^2^](#acn351103-bib-0002){ref-type="ref"} We have expanded these findings from a single case to multiple MS cases and included an additional RBP, TDP‐43. The heterogeneity of TDP‐43 phenotypes in FTLD is well studied.[^4^](#acn351103-bib-0004){ref-type="ref"}, [^5^](#acn351103-bib-0005){ref-type="ref"}, [^17^](#acn351103-bib-0017){ref-type="ref"} Abnormal TDP‐43 structures are typically classified into neuronal cytoplasmic inclusions, neuronal preinclusions, neuronal intranuclear inclusions, and dystrophic neurites and the distribution of and presence of these TDP‐43 features has been used to subtype FTLD and AD cases.[^18^](#acn351103-bib-0018){ref-type="ref"}, [^19^](#acn351103-bib-0019){ref-type="ref"}, [^20^](#acn351103-bib-0020){ref-type="ref"} Consistent brain regions are affected by FTLD and AD and can be more readily assessed for TDP‐43 pathology. MS is a heterogeneous disease that affects different parts of the CNS in different cases and to varying severities. In order to account for the amount of heterogeneity observed in MS and the varying degrees of RBP mislocalization reported in the literature,[^8^](#acn351103-bib-0008){ref-type="ref"}, [^14^](#acn351103-bib-0014){ref-type="ref"} we used a method of quantifying and phenotypically classifying RBP localization in tissue. These phenotypes ranged from homeostatic RBP nuclear localization to mild mislocalization and to severe RBP nuclear depletion with cytoplasmic accumulation, which are features of pathologic neurons in other neurologic diseases.
Using this phenotypic classification system, we analyzed 12 MS cases and six control cases compromising of more than 2700 cortical neurons for hnRNP A1 and TDP‐43 localization. We found that both of these RBPs exhibited differential phenotypic distribution in neurons in the normal appearing cortex of MS patients as compared to controls. Specifically, MS patients showed a reduction in the number of neurons with nuclear hnRNP A1 and TDP‐43 and a significant increase in the number of neurons with decreased nuclear localization and cytoplasmic mislocalization. Cortical neuron phenotypes 6 and 7 have the greatest degree of cytoplasmic staining (representative of nucleocytoplasmic mislocalization), which has been strongly associated with neurodegeneration and neuronal injury in other neurological diseases and their models.[^10^](#acn351103-bib-0010){ref-type="ref"}, [^14^](#acn351103-bib-0014){ref-type="ref"}, [^21^](#acn351103-bib-0021){ref-type="ref"}, [^22^](#acn351103-bib-0022){ref-type="ref"}, [^23^](#acn351103-bib-0023){ref-type="ref"}, [^24^](#acn351103-bib-0024){ref-type="ref"} Remarkably, we could not find any of phenotypes 6 or 7 in cortical neurons of normal control brain, while there were at least some of these neuronal phenotypes in every MS case studied.
Nuclear localization of RBPs is believed to be physiologic while varying degrees of mislocalization have been shown to be detrimental to cellular processes and cell health and associated with neurologic disease pathology. In ALS, there is a correlation with the degree of mislocalization and disease severity in that increased amounts of cytoplasmic RBPs are associated with more severe forms of disease.[^25^](#acn351103-bib-0025){ref-type="ref"}, [^26^](#acn351103-bib-0026){ref-type="ref"} Several hypotheses have been proposed to explain the pathological and damaging effects of RBP mislocalization. The first hypothesis is a gain of toxicity in the cytoplasm postulating that increased cytoplasmic concentrations of an RBP alters its liquid‐liquid phase separation dynamics leading to the formation of insoluble protein aggregates.[^27^](#acn351103-bib-0027){ref-type="ref"}, [^28^](#acn351103-bib-0028){ref-type="ref"} Decreased RNA availability in the cytoplasm can cause RBPs to become more aggregate prone[^27^](#acn351103-bib-0027){ref-type="ref"} while increasing concentrations of proteins that have the potential to aggregate increases the probability of liquid to solid aggregate transitions.[^28^](#acn351103-bib-0028){ref-type="ref"} Furthermore, in ALS mouse models, TDP‐43 has been shown to mislocalize to the cytoplasm and abnormally bind and splice cytosolic RNA targets.[^26^](#acn351103-bib-0026){ref-type="ref"}, [^29^](#acn351103-bib-0029){ref-type="ref"} The presence of insoluble aggregates in a cell might create problems with the protein clearance machinery negatively impacting cellular health. Interestingly, our results demonstrate colocalization of hnRNP A1 and TDP‐43 to the cytoplasm of neurons in MS patients but not controls, suggesting that the formation of RBP aggregates although further experiments are needed to confirm this.
Other researchers suggest that dysfunctional RBPs lead to neurodegeneration through loss of function of the RBP in the nucleus. Nuclear perturbations of a target RBP suggest it is no longer performing its necessary functions within the nucleus. For example, nuclear depletion of TDP‐43 leads to lack of proper RNA processing, including disrupted splicing regulation, transcription, control, and micro‐RNA processing[^30^](#acn351103-bib-0030){ref-type="ref"} and has been shown to be sufficient to induce neuronal cell death.[^23^](#acn351103-bib-0023){ref-type="ref"} Findings from others often demonstrate nuclear depletion or loss of nuclear RBPs in conjunction with cytoplasmic accumulation of the RBP in neurons suggesting that it is most likely a combination of RBP gain of toxicity in the cytoplasm and loss of function in the nucleus that contributes to neuronal dysfunction and death.[^26^](#acn351103-bib-0026){ref-type="ref"} Our data suggest that a similar mechanism may be involved in MS pathogenesis whereby hnRNP A1 and TDP‐43 nuclear depletion and cytoplasmic accumulation lead to neuronal injury through gain of toxicity in the cytoplasm and loss of nuclear function. Further experiments are needed to elucidate the precise mechanism by which hnRNP A1 and TDP‐43 dysfunction influence neuronal health in MS.
A number of factors, including oxidative stress, proinflammatory cytokines, and inflammation, have been shown to influence RBPs in neurons.[^2^](#acn351103-bib-0002){ref-type="ref"}, [^31^](#acn351103-bib-0031){ref-type="ref"}, [^32^](#acn351103-bib-0032){ref-type="ref"}, [^33^](#acn351103-bib-0033){ref-type="ref"} Furthermore, mutations within RBPs, including hnRNP A1 and TDP‐43, have been shown to be causative of ALS and FTLD. We have previously shown that proinflammatory cytokines, antibodies to hnRNP A1, and MS‐associated mutations within hnRNP A1 lead to its mislocalization from nucleus to cytoplasm in in vitro models.[^2^](#acn351103-bib-0002){ref-type="ref"}, [^34^](#acn351103-bib-0034){ref-type="ref"}, [^35^](#acn351103-bib-0035){ref-type="ref"} We and others have also demonstrated that hnRNP A1 and TDP‐43 neuronal mislocalization is a prominent feature in mouse models of MS.[^11^](#acn351103-bib-0011){ref-type="ref"}, [^36^](#acn351103-bib-0036){ref-type="ref"} Particularly, we found that the degree of hnRNP A1 mislocalization positively correlated with experimental autoimmune encephalomyelitis disease severity and negatively correlated with neuronal cell count.[^36^](#acn351103-bib-0036){ref-type="ref"} This suggests that the severity of RBP mislocalization may be related to neurodegeneration and disease progression. Although it is unclear what is influencing RBP distribution in MS and related rodent models, it is clear that dysfunctional RBP biology is a prominent feature and could be influencing disease progression and pathology in a manner similar to other neurologic diseases.
This study was limited to RBP distribution in cortical neurons. However, research from others indicates that RBP localization may also be important in oligodendrocytes.[^11^](#acn351103-bib-0011){ref-type="ref"}, [^37^](#acn351103-bib-0037){ref-type="ref"} For example, selective depletion of TDP‐43 in oligodendrocytes in mice leads to increased mortality, decreased myelination, and neurological deficit development.[^37^](#acn351103-bib-0037){ref-type="ref"} These experiments are further supported by data demonstrating RBP mislocalization, specifically TDP‐43, in oligodendrocytes in the Theiler\'s murine encephalomyelitis virus model of MS.[^11^](#acn351103-bib-0011){ref-type="ref"} The role of RBP dysfunction in other glial cells, such as microglia and astrocytes, which are particularly relevant to MS pathology, is relatively unclear although research suggests that inflammation can induce RBP mislocalization in these cell types as well.[^31^](#acn351103-bib-0031){ref-type="ref"} Furthermore, recent proteomic analyses determined that TDP‐43 was differentially regulated in T cells from MS patients as compared to healthy controls further suggesting a role for dysregulated TDP‐43 and other RBPs in MS pathology.[^38^](#acn351103-bib-0038){ref-type="ref"}
Overall, we believe that this robust analysis of TDP‐43 and hnRNP A1 localization in cortical neurons in MS patients demonstrates a role for dysfunctional RBP biology in disease and suggests a novel mechanism underlying neurodegeneration in MS.
Author Contributions {#acn351103-sec-0018}
====================
HES contributed experimental data and analyses and wrote and edited the manuscript. CH contributed the experimental data. BFP contributed human pathology expertise. MCL contributed to the experimental design and interpretation, reviewed, edited, and approved the final version of the manuscript, including figures. All authors read and approved the final manuscript.
Conflicts of interest {#acn351103-sec-0019}
=====================
The authors declare no conflicts of interest.
The authors would like to thank Anita Givens, University of Saskatchewan for her guidance and expert technical assistance, and the Department of Pathology and Laboratory Medicine, Saskatoon Health Region, Saskatoon, Canada for retrieval of some of the tissue blocks used in this study. Some human tissue used in this study was obtained from the NICHD Brain and Tissue Bank for Developmental Disorders under contracts N01‐HD‐4‐3368 and N01‐HD‐4‐3383.
|
Q:
Pagebreak within the List of Figures
How can I have a page break manually inserted into the list of figures (\listoffigures)? I need a page break after a certain line/image-caption.
Consider MWE:
\documentclass[14pt, a4paper]{extreport}
\usepackage[left=3.5cm, right=2.5cm, top=3cm, bottom=3cm]{geometry}
\usepackage[toc,page]{appendix}
\usepackage{caption}
\usepackage{graphicx}
\begin{document}
\renewcommand{\contentsname}{Table of Contents}
\tableofcontents{}
\addcontentsline{toc}{chapter}{Table of Contents}
\newpage
%%------------List of Figures----------------------
\listoffigures{}
\addcontentsline{toc}{chapter}{List of Figures}
\chapter{someCH}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{bb}
\end{figure}
\part*{Test}
\markboth{}{}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{name}
\end{figure}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{bbb}
\end{figure}
\addtocontents{lof}{\protect\pagebreak}
\appendix
\chapter{chapt}\label{a.b}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{name}
\end{figure}
\end{document}
A:
you need to add the extra line with the page break after the pages on to which the other floats had floated (or add it within the float) placing it in the first appendix is simplest here
\documentclass[14pt, a4paper]{extreport}
\usepackage[left=3.5cm, right=2.5cm, top=3cm, bottom=3cm]{geometry}
\usepackage[toc,page]{appendix}
\usepackage{caption}
\usepackage{graphicx}
\begin{document}
\renewcommand{\contentsname}{Table of Contents}
\tableofcontents{}
\addcontentsline{toc}{chapter}{Table of Contents}
\newpage
%%------------List of Figures----------------------
\listoffigures{}
\addcontentsline{toc}{chapter}{List of Figures}
\chapter{someCH}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{bb}
\end{figure}
\part*{Test}
\markboth{}{}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{name}
\end{figure}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{bbb}
\end{figure}
\appendix
\chapter{chapt}\label{a.b}
\addtocontents{lof}{\protect\pagebreak}
\begin{figure}[htbp]
\centering
\includegraphics[height=8cm]{example-image-b}
\caption{name}
\end{figure}
\end{document}
|
North Pond Hermit accepted into alternative sentencing program
Christopher Knight (left) stands with his attorney, Walter McKee, during a dispositional conference at Kennebec County Superior Court in Augusta recently.
AUGUSTA, Maine — Christopher Knight, also known as the North Pond Hermit, will enter a special court program aimed at helping people with mental health and substance abuse problems who commit crimes stay out of jail.
The Co-Occurring Disorders Court formally accepted Knight earlier this week, Kennebec and Somerset County District Attorney Maeghan Maloney announced Friday.
Under terms of the court, Knight would plead guilty to the charges against him but remain free in the community under “intense” supervision. “It typically takes one to three years to graduate from the court,” Maloney said in a prepared statement. “If a member is not successful, the consequence is an automatic state prison sentence.”
Knight, 47, was indicted by a Kennebec County grand jury in August on six burglary charges and five theft charges. Knight claimed to have lived alone in the woods near North Pond in Kennebec County for 27 years, surviving in part by stealing from camps. Earlier in August, he was indicted by a Somerset County grand jury on one count each of burglary and theft. The Somerset County case was transferred to Kennebec County.
Knight has been incarcerated at Kennebec County Jail in Augusta since his arrest April 4 in Rome. His bail remains at $25,000, with the condition that only family members could post bail.
The Co-Occurring Disorders Court is an alternative sentencing court, according to Maloney. Both Maloney and Knight’s attorney, Walter McKee, recommended Knight for the court, Maloney said.
“When he’s released, we wanted a group that would be responsible for helping him reacclimate to society,” Maloney said in a telephone interview Friday. “This assists him in becoming a member of society, but it also requires many things of him.”
The court will require that Knight go to counseling every week. He must not use or possess illegal drugs or alcohol. He must work, volunteer or go to school full time. There are a number of other conditions that could be added, she said.
McKee said Friday that he feels this is the best option for Knight.
“It provides an opportunity for him to both accept responsibility for what he did and reintegrate him into a society that he’s not been involved in for nearly three decades,” said McKee, adding that Knight agrees with being accepted into the Co-Occurring Disorders Court.
Some details still need to be worked out, said McKee.
“It’s all about the endgame — where does he go? What does he do?” McKee said.
Because the court is for co-occurring disorders, the person being admitted must have two illnesses. In Knight’s case, he has alcohol and mental health problems, said McKee. He would not specify what mental health problem Knight was facing.
He added that he expects Knight to plead guilty Wednesday when he appears in Kennebec County Superior Court in Augusta. He then will be officially be in the Co-Occurring Disorders Court.
The special court was formed in Kennebec and Somerset counties in 2005 out of the growing recognition that people with mental illness and substance abuse disorders fare poorly in jail, according to the mainepretrial.org website.
Those referred to the court are screened by Maine Pretrial Services forensic case managers. Judges, prosecutors, lawyers and other stakeholders decide whether to accept a referral. |
NEW DELHI,
JAN. 3.
A week after tsunami the earthquake-triggered tidal waves struck the coastal States in the south, the Centre has continued to pump in more relief material today in the worst-hit Andaman and Nicobar Islands.
The Centre maintained that at least two inhabited islands in the Andaman and Nicobar region would require ``more or less reconstruction'' to a large extent.
At a joint briefing, the Chief of the Integrated Defence Services (IDS), Vice-Admiral Raman Puri, said the Pilmillow Island in South Nicobar had more or less submerged and survivors located at the island had been shifted to safer places at Campbell Bay.
Vice-Admiral Puri said that 65 per cent of Chowra, another island, had submerged. Thirtynine deaths were reported from this area while thirtysix persons were missing. The 100-foot lighthouse at ``Indira Point'', the southernmost tip of the country, continued to be under water and it was confirmed that the entire staff of the lighthouse had been washed away.
``Operation Seawave'', the relief work launched by the Navy, had set up a relief camp in Great Nicobar where people from the island and other neighbouring small islands were being moved into. ``Efforts are now on to put more ships in service for the relief operations as they can carry greater loads and supplies,'' he said.
Navin Chawla, Information and Broadcasting Secretary, who is also a member of the Group of Secretaries looking into the relief measures, said that, on an average, about 350 tonnes of relief material was being sent to tsunami-affected areas. So far, about 1,000 tonnes of relief material had been despatched and 388 tonnes more was being airlifted or shipped.
Central team for Tamil Nadu, Kerala
The Central team, headed by A.K. Rastogi, Secretary in the Disaster Management Division of the Home Ministry, is leaving tomorrow for Tamil Nadu and Kerala to assess the situation.
The official death toll in the tsunami tragedy has climbed to 9,479, with Tamil Nadu accounting for 7,814 deaths, Kerala 166, Andhra Pradesh 106, Pondicherry 575 and the Andaman and Nicobar Islands 818. As many as 5,681 persons are still untraced or missing. Mr. Chawla said that rescue operations for the missing or feared killed persons had not been called off, citing an example of three Doordarshan employees being found alive on Sunday after a week when their SOS reached Car Nicobar.
The Government would set up desalination plants in the Andaman and Nicobar Islands. The Home Ministry had already consulted the Confederation of Indian Industry and the view was that advanced technology would help set up at least four mini-plants in the islands.
The Government expressed gratitude for the tremendous response from the public, NGOs and other agencies and encouraged people to extend a helping hand to the tsunami victims. |
Q:
Batch variable name in another variable
Assume I have a folder that contains other folders that I don't necessarily know about:
|Folder
| |-- SubFolder1
| |-- SubFolder2
| |-- SubFolder3
I essentially want to map another location for the sub folders. So I create another batch file containing these sub folder names that can have another location set to them, e.g:
TYPE NUL > folders.cmd
FOR /D %%i IN (*) DO (@ECHO SET %%i=>>folders.cmd)
which produces:
SET SubFolder1=
SET SubFolder2=
SET SubFolder3=
Then if I was to open that file and set some values like so:
SET SubFolder1=C:\test1
SET SubFolder2=C:\test2
SET SubFolder3=C:\test3
How would I now access the variables/values in my batch file (especially when I may not know what they are).
I thought maybe I could do something like:
CALL folders.cmd
FOR /D %%i IN (*) DO (
@ECHO %%%i%%%
)
But this appears to be the incorrect way to do it.
A:
The concept you use in this question is called array. You may use the methods described at this post in order to access array elements. For example:
SETLOCAL ENABLEDELAYEDEXPANSION
CALL folders.cmd
FOR /D %%i IN (*) DO (
ECHO !%%i!
)
... or:
CALL folders.cmd
FOR /D %%i IN (*) DO (
CALL ECHO %%%%i%%
)
EDIT: Output of CALL example added
C:\> dir /B
folders.cmd
SubFolder1
SubFolder2
SubFolder3
test.bat
C:\> type folders.cmd
SET SubFolder1=C:\test1
SET SubFolder2=C:\test2
SET SubFolder3=C:\test3
C:\> type test.bat
@echo off
setlocal
CALL folders.cmd
FOR /D %%i IN (*) DO (
CALL ECHO %%%%i%%
)
C:\> test.bat
C:\test1
C:\test2
C:\test3
|
/**
* SyntaxHighlighter
* http://alexgorbatchev.com/SyntaxHighlighter
*
* SyntaxHighlighter is donationware. If you are using it, please donate.
* http://alexgorbatchev.com/SyntaxHighlighter/donate.html
*
* @version
* 3.0.83 (July 02 2010)
*
* @copyright
* Copyright (C) 2004-2010 Alex Gorbatchev.
*
* @license
* Dual licensed under the MIT and GPL licenses.
*/
;(function()
{
// CommonJS
SyntaxHighlighter = SyntaxHighlighter || (typeof require !== 'undefined'? require('shCore').SyntaxHighlighter : null);
function Brush()
{
// Created by Peter Atoria @ http://iAtoria.com
var inits = 'class interface function package';
var keywords = '-Infinity ...rest Array as AS3 Boolean break case catch const continue Date decodeURI ' +
'decodeURIComponent default delete do dynamic each else encodeURI encodeURIComponent escape ' +
'extends false final finally flash_proxy for get if implements import in include Infinity ' +
'instanceof int internal is isFinite isNaN isXMLName label namespace NaN native new null ' +
'Null Number Object object_proxy override parseFloat parseInt private protected public ' +
'return set static String super switch this throw true try typeof uint undefined unescape ' +
'use void while with'
;
this.regexList = [
{ regex: SyntaxHighlighter.regexLib.singleLineCComments, css: 'comments' }, // one line comments
{ regex: SyntaxHighlighter.regexLib.multiLineCComments, css: 'comments' }, // multiline comments
{ regex: SyntaxHighlighter.regexLib.doubleQuotedString, css: 'string' }, // double quoted strings
{ regex: SyntaxHighlighter.regexLib.singleQuotedString, css: 'string' }, // single quoted strings
{ regex: /\b([\d]+(\.[\d]+)?|0x[a-f0-9]+)\b/gi, css: 'value' }, // numbers
{ regex: new RegExp(this.getKeywords(inits), 'gm'), css: 'color3' }, // initializations
{ regex: new RegExp(this.getKeywords(keywords), 'gm'), css: 'keyword' }, // keywords
{ regex: new RegExp('var', 'gm'), css: 'variable' }, // variable
{ regex: new RegExp('trace', 'gm'), css: 'color1' } // trace
];
this.forHtmlScript(SyntaxHighlighter.regexLib.scriptScriptTags);
};
Brush.prototype = new SyntaxHighlighter.Highlighter();
Brush.aliases = ['actionscript3', 'as3'];
SyntaxHighlighter.brushes.AS3 = Brush;
// CommonJS
typeof(exports) != 'undefined' ? exports.Brush = Brush : null;
})();
|
It is proved that every infinite-dimensional
non-archimedean Banach space of countable type admits a linear
continuous operator without a non-trivial closed invariant
subspace. This solves a problem stated by A.~C.~M. van Rooij and
W.~H. Schikhof in 1992. |
ALBANY - A state appeals court reversed the conviction of an Albany gang member accused of setting up the killing of a rival, ruling the trial judge should have never allowed jurors to view a video of a police interrogation in which the shackled suspect stayed silent.
In reversing Olaijaide Chapman's conviction in the plot to hire two hit men to kill Marquis Mitchell, the justices on the Appellate Division of state Supreme Court ruled unanimously that allowing jurors to see the video of Chapman sitting in silence while he was peppered with questions by detectives violated a well-established tenet of New York case law.
"There are many reasons why an individual may choose not to speak to the police; however, there is a substantial risk that jurors might construe such silence as an admission and draw an unwarranted inference of guilt," the justices wrote.
"Defendant is shown slouching, with an ankle shackle securing him to the chair, and he is dressed in a hooded sweatshirt with oversized sweatpants worn in a manner so as to expose his underwear," the ruling continues. "His attitude appears to be dismissive and, at one point, he laughs in response to police questioning. Throughout the video, defendant makes no inculpatory statements."
Use of the video was rejected during pre-trial hearings on the grounds it was prejudicial. But the justices wrote Judge Peter Lynch erred when he allowed prosecutors to show the jury a redacted version of the video. It ended up being the last thing shown to the jury before Assistant District Attorney Shannon Corbitt wrapped up her case at Chapman's May 2016 trial.
Chapman's post-trial lawyer, Lucas Mihuta, pursued two points in his appeal: That there was no evidence to back up testimony Chapman's accomplices made during the trial and that the video should not have been shown. The judges rejected the first argument but sided with Mihuta on the second, triggering the reversal.
Earlier: Tweets help convict Albany man in assassin-for-hire plot
Mitchell, who was 24 at the time of the trial, survived shooting but he lost an eye and suffered from constant seizures.
Prosecutors contended Chapman boasted on Twitter about his plans to assassinate a rival, attracting the attention of police.
Chapman, known as "Luka," was accused of hiring two hit men to kill Mitchell. The victim was shot on April 17, 2014, at Garden and Raymo streets in Albany.
One day before the shooting, Chapman tweeted, "Sendin my hittas."
He later tweeted, "Try me and end up smoked," and "See us know we mean business." After Mitchell was shot but before police knew about it, Chapman tweeted, "Hospital."
He also tweeted, "I started all this (expletive)!"
The jury deliberated an estimated 2½ hours over two days before it found Chapman guilty of offering the hit men $2,000 to ambush Mitchell under the guise of selling him tickets to a music show. The hitmen, Desonte Welch and Shaqquis Salmond, later cut deals with Albany County prosecutors and testified against Chapman.
Chapman, 29, was convicted of attempted murder, conspiracy and assault. He was ordered to serve 25 years to life in prison. He was serving his sentence at Clinton Correctional Facility in Dannemora. |
21 Comments
It'll make it easier, Sillies!
This way you won't have to walk back to your car to place a ticket inside, so those less physically able should find this *easier* than the current system. :-)
@Raewyn
Posted on 28-03-2017 16:52 | By Papamoaner
Not true. This is merely a software change. No hardware change has been suggested. Why on earth would they? The idea is to reduce infrastructure cost, not increase it. I travel a lot and am not aware of the "other towns" you refer to that have new machines that don't accept coins. Sorry, but I don't believe you.
Duh!
Posted on 28-03-2017 10:49 | By Raewyn
I think you will will find no coins anymore if it is like other cities!
@ DUH !
Posted on 27-03-2017 16:58 | By Papamoaner
You're all off topic. What has smart phones got to do with the price of fish? This argument is about whether you stick a docket on your car, or let the machine record it for you. Simple! The cost is the same, the philosophy of paying to park is the same. The difference is that this makes it easier for you.You can still push your coins through the wee hole.I think the initiative is perhaps beyond the intellect of the average motorist, just like the new roundabout rules that they simply don't understand, so try to do it by rote - and mostly get it wrong.
confused
Posted on 27-03-2017 15:46 | By gingerpussy
where does it say you need a smartphone?
Kill CBD
Posted on 27-03-2017 11:13 | By Raewyn
I find it crazy that Council would do such a thing like this to drive more people away from the CBD I dont have a smart phone and have no intention on getting one!I will be shopping for free in the suburbs!cbd
By overit asks,
Posted on 26-03-2017 23:19 | By Murray.Guy
Firstly, it is a corrupt process and mindset that singles out the City Centre for the 'double dipping' pay for curb side parking. There are NO costs to provide the CBD street level parking that do not exist in front of your home, your business, your playground and there is NO reason with ANY moral, integrity basis that justifies undermining the CBD economy in the way. That aside, the City Council staff cannot help themselves in regards 'copy & paste', keeping up with elsewhere regardless of the cost and or validity. TCC staff would have told the elected members, who like brainless sheep would have gone along with them, that it is critical to adopt the latest revenue options for the success of 'paid CBD parking'. Truth is, folk do still have that loose change in the car, the purse, and like Rotorua CBD, the old was adequate!
Whew !
Posted on 26-03-2017 20:49 | By Papamoaner
Some people will moan and whinge at anything that moves or changes. It's just another small technological advance. Give it a chance before whining, then if you're still not happy after a month or two, whinge your tiny brains out.
Sounds like a dumb idea
Posted on 26-03-2017 18:28 | By Angel74
to me, why change something that was working, as for a smart phone not everyone has one and its not just the elderly that will find the new system in the too hard basket..........we are trying to get people into town not keep them away.
Dear parking meters ......
Posted on 26-03-2017 17:37 | By begesch
.... I've lived in Tauranga for 10 and half years, and there has been three different parking meters, the fourth one coming up now. Why do we need such modern technologies, keep it simple, keep it easy for everyone, and use all that money for something more important. Constantly changing parking meters, prices, hours to pay etc will not bring more people into the town centre, it will keep more of them away.
Hello
Posted on 26-03-2017 16:43 | By overit
does Council give Trustpower employees a parking discount?
I disagree CC8
Posted on 26-03-2017 14:15 | By The Tomahawk Kid
CC8 says: these changes are only made to appease the property owners and developers. I dont believe that is so. Property owners charge rents to cover their investment. Council increase rates, Investors increase rents. This increase in costs to update the system has to be covered by someone - that will be the property owners. They want this less than you do! Council are parasites on the productive. Council simply see an opportunity to make money for doing nothing creative, and are exploiting it. They are driving people away from the CBD. YET they are in charge of trying to fix the CBD - You will NEVER get a resolution. Its like asking the wolf why the sheep are missing. They will not cease till the CBD is dead - then look for things/people to blame it on. Council are the cause of the problem -not the answer
@BnbyHro
Posted on 26-03-2017 13:54 | By The Sage
Many older people do not have Smart phones so the App thing is not going to work for them. They just won't go into the CBF so there will be even less shoppers. Also many of them struggle with the technical world and eyesight isn't so good so having to key in number plates will wipe out a few more punters.
Every step TCC takes is driving people away.
Posted on 26-03-2017 12:37 | By CC8
I for one will never stop in the so called CBD again. It is dying, these changes are only made to appease the property owners and developers. Trying to convince them that the old town Tauranga is in fact the center of commerce here...IT'S NOT...it is old downtown Tauranga , dead in the daytime and full of drunks at night. TCC spent god knows how much time and money convincing Trustpower to move to Durham Street, and telling the public and retailers that it is a good move...more bull, 500 people locked up in an ivory tower who get 30 mins lunch break , no advantage to retailers there! Oh they justify council parking buildings...council gives Trustpower employees a parking discount. Does that grey concrete block give vibrancy to the city? I hardly think so. I too will shop in the suburban malls hassle free and
well
Posted on 26-03-2017 12:33 | By Capt_Kaveman
there were better people to vote for so the same stigma is what you get
It's only money!
Posted on 26-03-2017 11:38 | By rosbo
Your time bought will be just that. One minute over and the next charge will come in.. if the first 10 mins is over, then a fine for not buying a ticket. It's a good way of making more money.
Smurf
Posted on 26-03-2017 11:28 | By BnbyHro
People from every demographic have been using this system all over the country for years perfectly well. Did you even read the article? You still pay at the machines, you just need to enter your license plate number. If that's too much use the parking app - even easier...
Last Nail in the Coffin!
Posted on 26-03-2017 10:57 | By Mackka
Well it's goodbye CBD for me! .. Hello Bethlehem :) If you have no paper receipt to prove how long you have been in a particular parking space - they can charge you what they like and you have no 'come back'! I can't see how this will save money - are they going to post me a bill for $0.50c or $1.00 for the odd occasion when I do need to go to the CBD? ... Council has spent million in recent years on a number of meter upgrades.... Will they now rip them out and get this new fangled system costing more millions? What is the matter with these people??Can someone please explain how this works? I don't have a 'Smart' phone and won't get one! If they keep the free after 3pm parking, town will be buzzing from 3-5p
Overit
Posted on 26-03-2017 10:27 | By overit
Why spend more money on parking machines. Whats wrong with the present system?
How about this
Posted on 26-03-2017 09:52 | By The Sage
Make the handicap parks free as they are in Hamilton. People have to walk some way to access these machines and, when you are able bodied that is fine, when you aren't it poses a problem. While you are at it TCC paint the handicap parks bright blues, in the CBD, as they are in many other places. Makes them more identifiable for the people who should not park in them.
Another reason not to shop in the city
Posted on 26-03-2017 09:24 | By smurf
What next. I can imagine our more elderly citizens will have much difficulty with this. Easier for the councils revenue collection but not user friendly. I would much rather put money in the ticket machine. I'm off to Bayfair or Papamoa. It will cost me more to drive there but who cares!! |
1. Introduction {#sec1-pharmacy-05-00043}
===============
The role of the pharmacist in some European Union (EU) members (e.g., Poland) is still under development, and remains limited to dispensing medicines despite the continuing efforts of pharmacists and academic bodies \[[@B1-pharmacy-05-00043]\]. Thus, we still observe the differences in the role of pharmacists and the place of community pharmacies between particular European countries. However, the recent proposed and introduced changes in the Polish pharmaceutical law should be considered as the next step in a long path to promoting innovative pharmacy practice into routine settings in an area where the implementation of pharmaceutical care is still in the primary phase. In this context, the amendments currently being discussed in Poland might be supportive for countries where the pharmacy profession is still under development. Among others, the discussion involved the concept of "pharmacy for pharmacist", as well as an extensive effort to introduce new services to community pharmacies, which are understood as the real beginning of pharmaceutical care in Poland. Finally, we will be touching on different aspects mainly associated with the drug policy, e.g., free drugs above 75 years old or the idea of over-the-counter (OTC) drugs available only in the community pharmacy which also have a vital impact on the pharmacy practice. The aim of this paper is to present the Polish attempt to introduce the new regulations designed to change the drug policy. In this sense, our brief review contributes to the global discussion about the future of the pharmacy practice in Europe.
2. Community Pharmacy in Poland---The Legal Framework {#sec2-pharmacy-05-00043}
=====================================================
The number of community pharmacies per 1,000 citizens in Poland remains relatively high, so logistical obstacles do not limit the access to pharmaceutical services \[[@B2-pharmacy-05-00043]\]. Moreover, we observe the constant consolidation of community pharmacies including more than 50 facilities \[[@B3-pharmacy-05-00043]\]. On the other hand, the role of the pharmacist is tied only to dispensing medications and/or providing little advice about dosage or how to properly store the drugs, although the pharmaceutical studies are conducted within the university setting \[[@B4-pharmacy-05-00043],[@B5-pharmacy-05-00043]\]. Apart from pharmacists in the community pharmacy, we can identify pharmaceutical technicians who fulfilled 2-year training as well as supportive staff, with respective responsibilities defined by the separated legal acts \[[@B6-pharmacy-05-00043]\]. Interestingly, in the past, almost everyone could be the owner of a community pharmacy. Nowadays, Polish legislation provides that only pharmacists may own and operate a pharmacy. The pharmaceutical law prohibits only the situation where physicians which are actively involved in their professional duties are the owner of the community pharmacy. Moreover, no more than 1% of community pharmacies can belong to one legal entity. Currently, every community pharmacy must be led by a manager with pharmaceutical education and a minimum of five years of experience in the community pharmacy or three years and specialization obtained during postgraduate education. The Pharmaceutical National Chamber is a professional self-governing body dedicated to caring for the profession and representing the community of pharmacists during the external negotiations \[[@B7-pharmacy-05-00043]\].
3. Pharmaceutical Care in Poland---Still Not Implemented {#sec3-pharmacy-05-00043}
========================================================
Pharmaceutical services lead to an improvement in treatment effect, as one can see in the context of taking care of patients diagnosed with cardiovascular diseases. Numerous studies have shown that pharmaceutical care leads a reduction in blood pressure, an improvement in lipid profile, and better glycemic control, as well as---in a broader perspective---increasing the degree of patients' adherence to recommended treatment \[[@B8-pharmacy-05-00043],[@B9-pharmacy-05-00043]\]. The definition of pharmaceutical care had already been introduced to the Polish legal system in 2008, and was described as a documented process in which the pharmacist should work with the patient, the doctor and, if necessary, with other medical professionals in the optimization of pharmacotherapy \[[@B10-pharmacy-05-00043]\]. Moreover, there are still many legal and organizational problems which prevent the implementation of effective pharmaceutical care to the Polish pharmaceutical practice, including; (i) disrupted flow of medical information between the doctor and the pharmacist; (ii) lack of separate places in community pharmacies which enable free and private conversation with the patient; and finally (iii) the difficulties associated with the access to confidential information, which undoubtedly includes those concerning patients' state of health \[[@B11-pharmacy-05-00043],[@B12-pharmacy-05-00043],[@B13-pharmacy-05-00043]\]. In the official document provided by the Pharmaceutical Care Section of the Polish Pharmaceutical Society which includes the strategy for Polish pharmacy, it is stated that effective implementation of pharmaceutical services will optimize pharmacotherapy, achieve more satisfactory outcomes, and improve the health-related quality of patients' lives. The key part of this implementation continues to be the effective harmonization of new services with a different part of the health care system, which should lead to the situation where the circulation between data obtained from pharmaceutical services is easily transferred from community pharmacies to the general practitioner (GP) and vice versa. According to this statement, groups regarded as beneficiaries of pharmaceutical care are geriatric and chronically ill patients who were affected by polypharmacotherapy \[[@B14-pharmacy-05-00043]\]. In the Polish health care system, the efficacy of clinical pharmaceutical care has so far been investigated in the context of hypertension. Skowron et al. showed a reduction of blood pressure in the study group covered by the pharmacist intervention based on the knowledge of hypertension, as well as the detection of drug-related problems with recommendations \[[@B15-pharmacy-05-00043]\]. The implementation and popularization of pharmaceutical care and pharmacists' greater activity in the context of the health care system in Poland may contribute to the rationalization of available resources. For instance, the introduction of repeat dispensing as one of the new services to community pharmacies can limit the number of patient consultations aimed at receiving new prescriptions from GPs \[[@B16-pharmacy-05-00043]\]. In this context, it is worth noting that the health care system in Poland faces some system problems such as long waiting lists to see a specialist or have surgery and a persistent shortage of doctors and nursing staff \[[@B17-pharmacy-05-00043]\]. Following this, nurses and midwives have recently received permission to prescribe some medicines that previously only doctors were authorized to prescribe, while the pharmacists still do not have similar right \[[@B18-pharmacy-05-00043]\].
4. Reimbursed Services---The Future of Pharmacy Practice in Poland {#sec4-pharmacy-05-00043}
==================================================================
The works on the concept of pharmaceutical care reimbursed from public funds gained momentum in August 2015 when the government established the Pharmaceutical Care Team at the Ministry of Health. Its task is to develop regulatory frameworks and specific legal solutions aimed at the introduction of advanced pharmaceutical services to everyday pharmaceutical practice. So far, the published information indicates that the actions of the above-mentioned team focus on two types of pharmaceutical services: giving advice to patients on the correct use of inhalers and medication review services. These services---at least in their initial stage of introduction---focus on elderly patients with chronic diseases and those affected by polypharmacy. The right to provide reimbursable services will be given to all pharmacies, which have signed a contract with the National Health Fund---an institution supervising the process of reimbursing health benefits from public funds. According to one of the concepts, a patient will have the right to choose one particular community pharmacy and will confirm this decision with a written declaration \[[@B19-pharmacy-05-00043]\]. According to the unanimous opinion of all the parties, pharmaceutical care service should be reimbursable from public funds, and the patient's participation in the costs should be marginal. The party which is most involved in the changes leading to an increase of the pharmacist's role and greater importance of the place of community pharmacies in the Polish health care system remains The National Pharmaceutical Chamber, the body legally representing the demands of pharmacists in the negotiations, for example, with the government. At the beginning of September 2016, the Pharmaceutical Care Team was closed by ministerial decision. To best of our knowledge, so far, no official statement including the results of the working of the above-mentioned group has been publicly announced \[[@B20-pharmacy-05-00043]\].
5. New Deal in Community Pharmacies---"Pharmacy for the Pharmacist" {#sec5-pharmacy-05-00043}
===================================================================
At the beginning of April 2017, the President of Poland signed a new act which officially introduced the concept of "pharmacy for the pharmacist" \[[@B21-pharmacy-05-00043]\]. This new act also brought forth other immediate changes to the pharmacy practice. In detail, the postulated act clarified that only a pharmacist or a partnership consisting solely of fully-qualified pharmacists can manage and control up to a maximum of four community pharmacies. According to the Polish Pharmaceutical Chamber, this number should allow for a direct and proper supervision of the community pharmacy setting, and consequently, improve patient safety. The new regulations also provided geographic limits for any newly-created community pharmacies. A new pharmacy could be opened when the number of people calculated per single pharmacy equals or exceeds 3000 individuals in a particular district and the distance from the planned location of the new pharmacy to the nearest accessible community pharmacy is at least 500 m \[[@B22-pharmacy-05-00043],[@B23-pharmacy-05-00043]\]. "Pharmacy for the pharmacist" means that the main owner of community pharmacy should be a person with higher education and who has a license to practice a profession of a pharmacist in the Republic of Poland. In the opinion of the Polish Pharmaceutical Chamber (Supreme Pharmaceutical Council), this concept will lead to greater control over community pharmacies and strengthen the professional independence of the pharmacists \[[@B24-pharmacy-05-00043]\]. The proposed changes are criticized by some organizations, which indicate that the legislation presented above may be unconstitutional, against European Union law, and cause an increase in the price of medicinal products \[[@B25-pharmacy-05-00043],[@B26-pharmacy-05-00043]\]. Apart from the demands to introduce pharmaceutical care, currently there is also discussion on the concept of a separate act---The Act on the Profession of Pharmacist---which shall be a summary and collection of so-far scattered regulations.
6. OTC Drugs---Only in Community Pharmacies {#sec6-pharmacy-05-00043}
===========================================
It is worth mentioning the demands of the restriction of the non-pharmacy distribution of drugs; at present, some of the medicinal products available OTC are also available in convenience stores or petrol stations and are dispensed by people without even basic pharmaceutical education \[[@B27-pharmacy-05-00043]\]. These proposals are subject to intense criticism from organizations that bring together representatives of chain pharmacies. The proposed changes are contrary to the provisions of economic freedom, and may be in conflict with the Constitution of the Republic of Poland---a central piece of legislation in Poland with which other adjustments must be compliant \[[@B28-pharmacy-05-00043]\].
However, it should be noted that in the EU we do not identify a unified drug policy in the context of the availability of OTC medicinal products in the non-pharmacy distribution, which is consistent with the freedom of lawmaking by the members of the European community. Consequently, we may find the countries where the OTC drugs might be placed only in community pharmacy settings, such as Germany or Austria. For instance, in Germany, only dietary supplements and some herbal or homeopathic products can be purchased outside pharmacies. We may meet the same regulations in Spain, France, or Greece. On the contrary, a different and more liberal approach can be found in Italy or Denmark. Nevertheless, the tendency in the EU is focused on reducing the non-pharmacy distribution of drugs, and most OTC medicinal products can be purchased mainly in community pharmacies \[[@B29-pharmacy-05-00043],[@B30-pharmacy-05-00043]\].
7. Free Drugs for Patients above 75 Years Old {#sec7-pharmacy-05-00043}
=============================================
The government has also made an effort to alleviate the financial burden associated with the purchase of medicines by the elderly. Currently in Poland there is a complex system for the reimbursement of medicinal products from public funds, and the level of patient co-payments for drugs remains one of the highest in Europe. On 1 August 2016, a project was published containing the list of medicinal products which will be free for patients above 75 years of age. This document provides a list of 1129 medicinal products containing a total of 68 active substances related to the treatment of old-age-diseases, including cardiovascular diseases, neurological disorders (e.g., Alzheimer's disease), or mood disorders (e.g., depression). It is estimated that these changes are expected to contribute up to ca. 82 million dollars savings for geriatric patients \[[@B31-pharmacy-05-00043],[@B32-pharmacy-05-00043]\]. The primary objective of this project is to improve adherence. The patient's high co-payment from their funds remains one of the causes of lower adherence \[[@B33-pharmacy-05-00043]\]. However, it should be stressed that it does not solve the multifaceted problem of patient adherence. This is proved by the fact that the phenomenon of non-adherence also exists in countries such as the UK, where the majority of medicinal products are available free of charge for large groups of patients \[[@B34-pharmacy-05-00043]\]. Therefore, the introduction of the list of free drugs for elderly patients should be considered a first step towards improving adherence and starting a debate on this issue.
8. Falsified Medicines Directive---New Responsibilities for Community Pharmacists {#sec8-pharmacy-05-00043}
=================================================================================
The implementation of EU regulations of the Falsified Medicines Directive (FMD) remains challenging and has been scarcely discussed so far \[[@B35-pharmacy-05-00043]\]. Undoubtedly, the introduction of the FMD will lead to improvements in patient safety, but will also be associated with increasing staff demand as well as new responsibilities for community pharmacists \[[@B36-pharmacy-05-00043]\]. Authentication will be the new and obligatory duty for pharmacists, which can be problematic in the Polish context due to the permanent lack of staff. Moreover, new software should be adequately introduced to avoid the possibility of errors in dispensing and to minimize disturbances in the workflow. It is worth mentioning that due to the legal proposals of FMD, the pharmacists will be able to detect falsified drugs easily and consequently remove them from the market \[[@B37-pharmacy-05-00043]\]. In addition, the collection of safety alerts (e.g., adverse drug events) will also be more feasible \[[@B38-pharmacy-05-00043]\].
All of these factors can lead to the conclusion that FMD will be beneficial in improving health care by the optimization of treatment. Indeed, the costs of its implementation should also be warranted and will not be limited to purchasing new software, but will be associated with the adjustment of community pharmacies to new requirements (e.g., logistics-related problems). The issue of the implementation of FMD in Polish pharmacies has already been succinctly discussed by other authors. Indeed, as a border country of the EU, Poland remains an important channel of illegal drug distribution and trade from "East to West". Thus, the effectiveness of FMD implementation will be an integral part of the success of amendments proposed by the European Community, and in that sense, Polish pharmacists hold significant responsibilities for patient safety in the whole of Europe \[[@B35-pharmacy-05-00043]\].
9. Other Challenges and a Glimpse of the Future {#sec9-pharmacy-05-00043}
===============================================
Obviously, our review does not cover all the topics which have recently become issues of discussion among Polish pharmacists. In addition, the introduction of the list of free medicines for elderly people also contributes to the return to the public debate about the problem of the lack of availability of certain medicinal products in community pharmacies (e.g., anticoagulants). This widely-discussed topic was one of the reasons for the introduction of regulations tightening the export of medicines outside the territory of Poland and even sanctioning this practice for some drugs---especially those which may not be accessible for Polish patients \[[@B39-pharmacy-05-00043]\]. Moreover, another matter postulated by the pharmacists is to uphold the existing law which prohibits any form of advertising of pharmacies, including in the shape of loyalty cards entitling the patient to the promotional purchase of drugs \[[@B40-pharmacy-05-00043]\]. The changes can also be seen in the undergraduate education of pharmacists; some faculties have introduced subjects more focused on clinical skills and aiming at deepening the pharmacists' medical knowledge. Such classes often take place in university clinics, which allows students to have direct contact with the patient \[[@B41-pharmacy-05-00043]\]. We summarized all amendments mentioned above in [Table 1](#pharmacy-05-00043-t001){ref-type="table"} and [Figure 1](#pharmacy-05-00043-f001){ref-type="fig"}. To sum up, the availability of community pharmacies---almost unlimited from the patient's perspective---and the skills and knowledge of Polish pharmacists remain an untapped resource of the Polish health care system. Given the aging society and the observed worldwide trend of broadening the professional competence of pharmacists towards services optimizing pharmacotherapy and promoting pro-health education, the introduction of pharmaceutical care and legal changes in the distribution of the medicinal products in Poland should be considered highly necessary and useful. Without a doubt, Polish pharmacists are impatiently awaiting changes described in this comment and are ready for far-reaching changes in the pharmacy practice---Yes, we can!
Damian Swieczkowski prepared and revised the manuscript. Milosz Jaguszewski and Piotr Merks supervised the project. All authors had substantial contribution and completed manuscript in a significant matter.
It must be emphasized that this publication was created purely for practice and academic interest and must not be construed in any way as an investment or business recommendation.
{#pharmacy-05-00043-f001}
pharmacy-05-00043-t001_Table 1
######
Changes in the pharmacy practice in Poland---highlights.
Highlights
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
The introduction of pharmaceutical care to the Polish health care system will contribute to the consolidation of the pharmacist's role and the place of pharmacies in Poland.Pharmaceutical care in Poland is to become a service reimbursable from public funds, particularly among patients with chronic diseases as well as the geriatric population.Implementation of the list of free-of-charge medicines for the elderly may lead to an improved adherence. However, this change should be the first step on the long path to solving the problem of non-adherence among Polish patients.The party most active in promoting the increasing role of the pharmacist in Poland remains The National Pharmaceutical Chamber. Some of the self-government's demands are subject to intense criticism, especially in the context of the compatibility of the proposed amendments to the Constitution and the principle of economic freedom.An important challenge---to date discussed in the public debate to a small extent---is the implementation of provisions of the Falsified Medicines Directive (FMD) and the harmonization of national legislation with EU regulations into the Polish legal system.
|
Before sunrise one day in December, thieves sneaked into Anshu Pathak’s exotic meat farm in Riverside County and pulled off a singular heist.
Someone cut away a section of fence. The evidence, Pathak said, suggests that they backed a trailer into the gap and lured up to 30 llamas and 160 ostriches inside. Also, emus, lambs, goats, alpacas and geese.
Then, they were gone. Animal control officers and sheriff’s deputies wrangled about 50 additional llamas and emus that had spilled into the street. Another emu was found the next day wandering near Highway 74.
Days later, against the backdrop of the snow-capped San Bernardino Mountains, Pathak inspected the hastily patched gash in the barrier surrounding his Perris property. He was upset, sure. Yet he couldn’t help but appreciate the Noah-like coordination it took to make off with such a large menagerie of animals.
“It must be organized, you know,” Pathak said. “They planned it nicely.”
The burglary was weeks in the making, coming after controversy over the 14-acre farm, which animal rights activists allege is keeping livestock in inhumane conditions. Pathak has denied this, and he has the backing of animal control officers who said they visited every day for weeks; each inspection revealed no sign of neglect.
But from the activists’ standpoint, these weren’t thieves who took Pathak’s prized animals. They were liberators.
Elizabeth Ovando of Redlands picks up a baby goat at the animal farm for Exotic Meat Market in Perris. Animal control officers say they’ve seen no signs of neglect at the farm after weeks of daily visits. (Gina Ferazzi / Los Angeles Times)
Animal rights organizations call these operations “open rescues.” They go undercover and shoot video of a location where they believe animals are being neglected or abused before entering the property, en masse.
Such operations have a rich history in California.
In 1985, a group called the Animal Liberation Front broke into scientific laboratories at UC Riverside and took more than 450 animals, including a rare monkey, in what was described at the time as the biggest “rescue” raid of its kind in history.
More recently, six activists with a Berkeley organization called Direct Action Everywhere were charged with felony theft, burglary and conspiracy offenses on allegations of seizing chickens during rescues at farms in Sonoma County in 2018. They have all pleaded not guilty and have preliminary hearings scheduled later this year.
Groups such as Direct Action Everywhere openly publicize their rescues, often livestreaming them on Facebook, and make no effort to conceal participants’ identities.
No one has come forward to claim responsibility for the Dec. 30 break-in at Pathak’s farm. But 10 days before it took place, a Sherman Oaks nonprofit called the Animal Hope and Wellness Foundation issued a call for volunteers via Facebook.
“We will be doing a mass rescue this weekend, and will need help from those local to Los Angeles,” the post read. “There is a place in Riverside, where over a hundred animals are being kept. These animals are suffering, and appear to be housed on an abandoned lot. Animal Hope and Wellness has been investigating the scene, and due to the horrifying conditions have chosen to take action.”
Video from the property shows emus and geese wandering around a collection of overturned buckets and wheelbarrows, skirting an armless mannequin and a discarded toilet. At one point, volunteers step gingerly over the decomposing carcass of at least one large animal that’s partially buried in the dirt.
“There are well over a hundred animals. Geese, emus, donkeys, goats, alpacas, ostriches, dogs with no access to running water, dying and starving,” the post read. “In addition to needing trailers and volunteers, we will need a place to take some of the animals.”
The organization did not respond to requests for comment.
Pathak is reluctant to attribute blame to an animal rights organization; he thinks it’s more likely that the spotlight it turned on his operation attracted other, more criminally-minded opportunists.
“An animal activist is an animal activist,” he said firmly. “A thief is a thief.”
Pathak can’t fathom why anyone would believe his animals need rescuing.
“Have you ever seen any farm like this?” he asked while leading a reporter on a tour of the property. “Have you seen this open farm with this many birds happy, food, running around?”
One by one, he introduced them like relatives at a family reunion. There was a water buffalo named Gorgeous: “She’ll come to you, she’s very loving.” An appaloosa llama, its snowy fur spotted with brown: “That’s the most beautiful, that girl.” A particularly impressive ostrich that stands 9 feet tall. A “French beautiful chicken.”
Llamas, alpacas, ostriches and other animals roam near a non-permitted mobile home and debris on leased land near Anshu Pathak’s exotic meat farm. (Gina Ferazzi / Los Angeles Times)
Pathak says that any farm of a comparable size is bound to have livestock deaths, adding that male llamas and ostriches tend to fight with each other during breeding season and that his animals live with minimal human interference.
“They might kill me in front of you, you never know,” he said. “This is real wild life.”
But he strongly denies the allegations of neglect. Though he lives in Las Vegas, he says he visits the farm about twice a month and makes his workers send him time-stamped photos of the hose that connects to its well to make sure the water source is free of plankton and moths. The animals are fed 16,000 to 20,000 pounds of alfalfa and grain each week, he says.
“Understand one thing: I raise animals for meat,” he said. “So if I don’t feed my animals, how am I going to get the meat out of them?”
What Pathak has taken to calling “the drama” began in early December, he says, when an animal activist who lives in San Jacinto approached one of two caretakers who live on the farm full time and offered to gather donations for the animals.
But in soliciting the fundraising via Facebook, the woman made the situation seem desperate, “as if we are poor and we don’t have money to feed these guys,” Pathak said. He believes she also used the encounter as an opportunity to covertly photograph and videotape his land.
Other activists then picked up on the claims.
In mid-December, Kris Kelly, who runs a Beverly Hills animal rescue nonprofit called the Kris Kelly Foundation, posted on Facebook photographs taken from the street that showed emus and llamas standing near large puddles of water after a recent rain. She shared the farm’s address and questioned why Riverside authorities weren’t “doing anything to help these animals that are being STARVED and dropping dead left and right.”
The Riverside County Department of Animal Services was inundated with complaints, spokesman John Welsh said.
Anshu Pathak checks his phone as a curious ostrich peers. No one has claimed responsibility for the burglary on Pathak’s farm. But 10 days before the incident, the Animal Hope and Wellness Foundation put out a call for volunteers for a “mass rescue” in Riverside. (Gina Ferazzi / Los Angeles Times)
“I bring up that post because it led to this onslaught of apparently some activism on social media,” Welsh said. “And it appears some people might have taken matters into their own hands.”
In a phone interview, Kelly said that she had never been to the farm but that someone sent her the photos in a private Facebook message complaining of the conditions there.
“It was just somebody, I don’t know who they were,” she said. “They just wanted me to post so they could get attention toward it.”
About a week later, the Animal Hope and Wellness Foundation posted the video with a call for volunteers. The well-known animal rescue nonprofit counts celebrities as supporters and reported nearly $2.1 million in gross receipts on its 2017 federal tax return, the most recent year for which a filing was available.
The post received 1,200 reactions and was shared 785 times.
“Seven hundred and eighty-five shares,” Pathak said, shaking his head. “So how many people think I am a bad guy?”
Pathak was born in India and raised vegetarian as part of his Hindu Brahmin upbringing.
Then he made the unlikely transition to a carnivore, moved to the U.S. and founded Exotic Meat Market in 1989 — selling everything from alligator to zebra, he says proudly. He has run the farm in Perris for the last seven years.
But his animals haven’t always occupied the entire lot. The trash-strewn portion of the property where the video was shot doesn’t actually belong to him; it’s adjacent to one parcel he owns and a second that he leases, he said.
The previous tenants departed in a hurry, leaving behind remnants of an agricultural operation including a discarded drip irrigation system and a collection of ramshackle outbuildings, and the land became overgrown by weeds. Pathak says the landlord declined repeated requests to clean up the property or sell it to him.
So last January, he removed a fence separating his farm from the lot and let his animals graze in the area.
“If those weeds are here and if there’s a fire, I don’t want my animals to get burned like Australia,” he said.
Riverside County Code Enforcement is working with Pathak and the landlord to clear up land-use violations related to four open cases, one each for excessive animals, excess outside storage, a non-permitted mobile home and an occupied recreational vehicle, county spokeswoman Brooke Federico said. Pathak also said that he’s started spending some of his own money to clean up the space and that his landlord has promised to bring in some trash containers in the next couple of weeks.
In the meantime, it is the cluttered front portion of the property that abuts busy Orange Avenue, so the animals grazing among the debris are the first thing that passersby see.
And there are a lot of passersby — even more than usual since the claims against Pathak went viral on social media.
On Jan. 8, a small throng of spectators had pulled their cars over to the shoulder of Orange Avenue to take pictures of the giant birds that clustered near the fence. Before long, a Riverside County Sheriff’s deputy stopped to tell them to move along.
Inside the farm, an ostrich was chasing Officer Lupe Villa, of the Riverside County Department of Animal Services, through an open area for the birds to run that the caretakers call “the danger zone.” One of the caretakers was trying to wave off the large bird with an even larger stick.
Villa had been called to the property to investigate yet another complaint, a daily occurrence since the controversy took root last month. He’ll continue to come as long as people keep calling.
“We are a complaint-driven organization that responds to allegations of abuse,” Welsh said. “But I can’t stress enough that we have not seen any level of neglect or abuse on this property.”
As for the missing animals?
“Everybody has their own story,” Pathak said. “The real story is something else.” |
Mitt Romney, Jets owner to host fundraiser
Mitt Romney will join New York Jets owner Woody Johnson and Republican National Committee Chairman Reince Priebus in co-hosting a major party fundraiser in New York later this year that is expected to feature several potential presidential candidates.
People began receiving invitations to the Oct. 6 event this week. POLITICO obtained a copy of an invite to the gathering, which appears to be similar to one Johnson held last year.
Text Size
The special guests for the high-dollar event include New Jersey Gov. Chris Christie, Sen. Rand Paul of Kentucky, Ohio Gov. John Kasich, and Sen. Marco Rubio of Florida, all of whom are potential 2016 contenders. Sen. Kelly Ayotte of New Hampshire also is expected to attend.
The event will be held at Johnson’s home in New York City. Johnson was a major Romney supporter when the former Massachusetts governor ran for the White House in 2012. |
# Copyright 2018-2020 Streamlit Inc.
#
# Licensed under the Apache License, Version 2.0 (the "License");
# you may not use this file except in compliance with the License.
# You may obtain a copy of the License at
#
# http://www.apache.org/licenses/LICENSE-2.0
#
# Unless required by applicable law or agreed to in writing, software
# distributed under the License is distributed on an "AS IS" BASIS,
# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
# See the License for the specific language governing permissions and
# limitations under the License.
import streamlit as st
with st.echo():
a = 123
b = 456
|
Effect of amnioinfusion on the outcome of prenatally diagnosed gastroschisis.
Following recent data showing that an inflammatory response exists in the amniotic fluid of gastroschisis-affected fetuses, we hypothesized that amniotic fluid exchange or amnioinfusion would improve the prognosis of prenatally diagnosed gastroschisis. We compared the outcome of prenatally amnioinfused fetuses with gastroschisis to non-amnioinfused fetuses with gastroschisis. 10 patients undergoing this procedure were matched with 10 patients of our previous study. Comparisons were done on data including surgical procedure, follow-up in the NICU and the gastro-pediatric unit. Our results show that gastroschisis-affected fetuses undergoing amnioinfusion had a lower duration of curarization after surgery (2.2 +/- 1.9 vs. 6.8 +/- 6.9 days, p = 0.019), a shorter delay before full oral feeding (49.7 +/- 21.5 vs. 72.3 +/- 56.6 days, NS), and a shorter overall length of hospitalization (59.5 +/- 19.7 vs. 88.5 +/- 73.6 days, NS). We confirmed our previous data showing that amniotic fluid displays a chronic inflammation profile. Our data suggest that amnioinfusion could improve the outcome of gastroschisis affected fetuses. The hypothesis by which this improvement could be due to a reduction of an inflammatory response remains to be proved. |
WAG354G Disconnects with incoming Phone Call
Hope someone can help, I have a WAG354G router with the 1.01.05 firmware. The problem i keep experiencing that when an incoming phone call comes in the router drops connection and does not reconnect. Once this happens, if i perform a hard reboot it works fine until the next phone call.
Can any one help, does the problem reside with the router or my ISP???
That's more of a line problem that your DSL provider/phone company will need to look into. I worked for a DSL provider and connection drops were a common issue. Most of the time it was attributed to a line condition, more than a modem/hardware issue. Double-check to make sure you have your inline phone filters in place. Or if you have a POTS installed, you can skip that step. Just for kicks, try connecting the router to another phone jack (assuming no POTS is installed) and try it there. See if you get a disconnect on another phone jack. But like KoP siad, If all else fails a line test by your ISP will show any shorts or opens on the line. |
// Copyright 2017 Google LLC
//
// Licensed under the Apache License, Version 2.0 (the "License");
// you may not use this file except in compliance with the License.
// You may obtain a copy of the License at
//
// http://www.apache.org/licenses/LICENSE-2.0
//
// Unless required by applicable law or agreed to in writing, software
// distributed under the License is distributed on an "AS IS" BASIS,
// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
// See the License for the specific language governing permissions and
// limitations under the License.
// THIS FILE IS AUTOMATICALLY GENERATED. DO NOT EDIT DIRECTLY.
// Package fake has the automatically generated clients.
package fake
|
AK272 PANZER CREW BLACK UNIFORMS PAINTING GUIDE
4.11 - 1251 ratings - Source
The AK Learning Series continues to grow. In the second edition of the AK Learning Series we take a close look at Panzer Crew Figure Painting. This book is filled with articles, full color photographs and extensive step by step guides to make painting your figures a less intimidating task. We show you how to achieve realistically painted figures ranging from the classic black panzer uniforms to the more complicated camouflage patterned clothing. The reader is given multiple examples of how to paint heads/faces. This book offers extended text explaining the different techniques and styles of painting your German figures from WWII. Also included is a historical introduction, a military ranks chart, and a photo gallery for you to use as references.The reason for having all these mixtures prepared is the continuous coming and
going in the application of light and shadow. It is very important to add Tamiya
matte base in the process, so that the paint does not become glossy. 31 33
Usuallyanbsp;...
Title
:
AK272 PANZER CREW BLACK UNIFORMS PAINTING GUIDE
Author
:
Publisher
:
AK-INTERACTIVE, S.L. -
ISBN-13
:
You must register with us as either a Registered User before you can Download this Book. You'll be greeted by a simple sign-up page.
Once you have finished the sign-up process, you will be redirected to your download Book page. |
Hypermethioninaemia and 3-hydroxyisobutyric aciduria in an apparently healthy baby.
An apparently healthy baby with persistent hypermethioninaemia excretes increased amounts of 3-hydroxyisobutyrate, 3-hydroxypropionate, beta-aminoisobutyrate and beta-alanine. A defect in the oxidation of methylmalonic and malonic semialdehydes is proposed but the cause of the hypermethioninaemia is obscure. |
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# FIRST AUTHOR <EMAIL@ADDRESS>, 2011.
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"%s: Tamanho incorreto para o argumento de entrada #%d: as quantidades de "
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#, c-format
msgid "%s: Wrong type for input argument #%d: string expected.\n"
msgstr ""
"%s: Tipo incorreto para o argumento de entrada #%d: esperava-se um texto.\n"
#, c-format
msgid "%s: This function is forbidden in a concurrent execution context.\n"
msgstr "%s: Esta função é proibida em um contexto de execução concorrente.\n"
#, c-format
msgid "%s: Wrong number of input argument(s).\n"
msgstr "%s: Quantidade incorreta de argumentos de entrada.\n"
#, c-format
msgid "%s: %s module is not installed.\n"
msgstr "%s: O módulo %s não está instalado.\n"
|
IMCD cells in vivo and in culture secrete H+, mediated by an H+-ATPase, and absorb H2O mediated by aquaporin-2 (AQP2). In cultured rat IMCD cells and in intact IMCD segments, transport is regulated by SNARE mediated exocytic insertion and endocytic retrieval of vesicles carrying either the H+-ATPase or AQP2. Although exocytosis of H+-ATPase and AQP2 are independently regulated, they utilize a similar SNARE system for membrane targeting-fusion. In this proposal we will characterize the targeting process for these proteins and identify the disparate effects of SNARE regulators on H+-ATPase versus AQP2 membrane cycling. We will test the hypothesis that the B1 subunit of the plasma membrane H+-ATPase contains molecular information for targeting of the assembled H+-ATPase to the apical membrane. B1 is the isoform of the B subunit that is present in the H+-ATPase of cells specialized for proton secretion. The other isoform, B2, is present in the vesicular membrane H+-ATPase of all cells. We predict that the targeting information for the plasma membrane H+-ATPase is encoded in either the N or the C-terminal amino acids, the two regions of ATP6V1B1 that are most dissimilar from B2. Our studies will also determine the role of Munc 18-2 and snapin as SNARE regulators for H+- ATPase and AQP2. Munc 18-2, through PKC signaling, controls the apical targeting and insertion of H+-ATPase in IMCD cells by regulating its interaction with syntaxin. We hypothesize that Munc 18-2 controls plasma membrane AQP2 very differently by regulating both AQP2 exocytosis and endocytosis. We propose the following cycle: Munc prevents formation of a fusion complex by association with vesicular AQP2-VAMP. Upon PKA phosphorylation of AQP2, Munc dissociates from AQP2 and VAMP and vesicle fusion occurs delivering AQP2, VAMP and Munc to the plasma membrane. Upon dephosphorylation of plasma membrane AQP2, Munc reassociates with AQP2, concentrates AQP2 and VAMP in clathrin-coated pits where this complex of Munc-AQP2-VAMP is endocytosed into the cell interior. Lastly, the role of snapin, a recently identified SNAP and adenylate cyclase binding protein, will be evaluated. We propose that snapin regulates exocytosis of both H+-ATPase and AQP2 in IMCD cells. Upon snapin binding to SNAP-23, an increased number of SNAP-syntaxin complexes are formed which are the t-SNARE receptor for the vesicular VAMP, delivering H+-ATPase to the apical membrane. Snapin may also regulate AQP2 exocytosis by amplifying the vasopressin second message (cAMP) since it has been shown that upon PKA phosphorylation, snapin binds and activates adenylate cyclase. We believe these studies will provide novel paradigms for the regulation of these apical membrane transporters and provide newer modalities for the treatment of fluid and acid-base disorders. PUBLIC HEALTH RELEVANCE These studies will provide important new information concerning the mechanisms by which the kidney regulates water and acid-base balance and how these mechanisms are disrupted by genetic and acquired disease states. An enhanced understanding of these abnormalities could lead to the development of improved therapeutic interventions. |
Praying can be a very demanding task. While bringing our requests before God, there are times when an answer does not readily come. What happens after a period of time when there is no response from God? Here are some possible thoughts that can come to one's mind:
1. I'm not worthy to have my request fulfilled.2. God has other plans for me.3. I don't appear to be serious about praying before God.4. Maybe God has lost interest in what I have been requesting.
The list could continue as to why after a period of time, we would simply want to stop praying. However, Jesus did not want us to lose heart.
He presented a parable about a woman who comes before a judge who neither feared God nor had respect for people. She pleads for justice and because of her persistence is granted her request. Here is the story:
Luke 18:1-10 "Then Jesus told them a parable about their need to pray always and not to lose heart. He said, ‘In a certain city there was a judge who neither feared God nor had respect for people. In that city there was a widow who kept coming to him and saying, “Grant me justice against my opponent.” For a while he refused; but later he said to himself, “Though I have no fear of God and no respect for anyone, yet because this widow keeps bothering me, I will grant her justice, so that she may not wear me out by continually coming.” ’ And the Lord said, ‘Listen to what the unjust judge says. And will not God grant justice to his chosen ones who cry to him day and night? Will he delay long in helping them? I tell you, he will quickly grant justice to them. And yet, when the Son of Man comes, will he find faith on earth?’" NRSV
The story is to give us encouragement - even in cases where we are experiencing an injustice! We can pray to God for help! |
A Republican state lawmaker from western Pennsylvania has announced legislation to open additional state forest land to gas exploration in order to help fix bridges in the commonwealth.
Last week, the state Department of Transportation said Secretary Barry Schoch authorized either adding or increasing weight restrictions on about 1,000 structurally deficient bridges “because of legislative inaction” on transportation funding this summer.
State Rep. Rick Saccone, R-Allegheny and Washington counties, said taxpayers aren’t an endless source of money and the state needs to find alternative funding sources.
Specifically, his proposal would call for the state Department of Conservation and Natural Resources to take bids for natural-gas-exploration leases on 300,000 acres of available state forest land over the next three years, according to a news release.
It would raise $1.05 billion in the first three years in addition to royalty fees on all the marketable gas produced by successful wells, the release stated.
“We certainly cannot allow these bridges in need of repair to go neglected,” Saccone said in a statement. “But let’s not needlessly saddle taxpayers when we have an enormous natural resource in Marcellus shale available to us that is waiting to be tapped.”
The bridge postings could begin as early as Thursday, PennDOT said as part of its announcement. The commonwealth leads the nation for structurally deficient bridges with nearly 4,500, according to the agency. |
Brazilian nobility
The Brazilian nobility refers to the titled aristocrats and fidalgo families recognized by the Kingdom of Brazil and later, by the Empire of Brazil dating back to the early 19th century, when it was a colony of the Kingdom of Portugal. It existed until 1889, when a military coup d'état overthrew the monarchy and established the First Brazilian Republic.
History
The Brazilian nobility originated from the Portuguese nobility, during the time of colonial Brazil; the noble titles were a sign of political power among the elite. Some of the nobles were members of Portuguese noble lineages and even of the high nobility, especially the families that arrived during the first centuries of the colonization of Bahia, Sergipe, Pernambuco, Rio de Janeiro and São Paulo. The elevation of Brazil to the status of Kingdom, under the United Kingdom of Portugal, Brazil and the Algarves in 1815, led to the creation of the first Brazilian noble titles. With the Independence of Brazil from Portugal in 1822, the Empire of Brazil established its own system of nobility.
According to the Brazilian Constitution of 1824, only the Emperor had the right to confer titles and ranks on non-nobles. Unlike the former Portuguese and Luso-Brazilian titles—and most systems of aristocracy—a Brazilian noble title was only for the holder's lifetime and could not be inherited, similar to a British life peer. All nobles, regardless of title and rank, were entitled to the style of Excellency.
During the reign of Dom Pedro II and the advent of the commercialization of coffee, it was the great coffee-growers who began to collect such titles, being acquaintances of the coffee barons. According to Affonso de Taunay, around 300 holders had their income linked to coffee: farmers, bankers and traders. The title of baron thus became a symbol of the legitimization of local power, making those who held it intermediaries between the people and the government.
During this period the Brazilian Imperial Family sought to efface republican sentiments with a wide distribution of titles, mainly among important political leaders in the provinces, some aristocrats and also members of provincial oligarchies; 114 were awarded in 1888, and 123 in 1889.
Republic
With the proclamation of the republic in 1889, the aristocracy was abolished and all Brazilian titles of nobility were banned. It was also prohibited, under penalty of accusation of high treason and the suspension of political rights, to accept noble titles and foreign decorations without the permission of the State. However, nobles of greater distinction, out of respect and tradition, were allowed to use their titles during the republican regime; a well-known example is the Baron of Rio Branco. The Imperial Family was not allowed to return until 1921, when the Law of Exile was repealed by President Epitácio Pessoa.
Acquisition
To be qualified for ennoblement, one could not be of illegitimate birth, be previously charged for lese-majeste, or have a history of engagement in a mechanical trade or be of "impure" blood (e.g., Jewish ancestry, the law of sangre pura). Most had to pay a large sum for the conferral of noble status (the Portuguese monarchs sold titles for payment to raise funds giving Portugal many nobles, 600+ families, for a small population), even if titles passed to their descendants.
A recipient had to pay the following fees depending on the title given, in contos de réis, according to the table of April 2, 1860:
In addition to these amounts, there were the following costs:
Roles for the petition: 366$000
Coat of arms registration: 170$000
A list of possible grantees was drawn up by the Council of Ministers, with recommendations from their colleagues, provincial presidents, other nobles, politicians, senior officials, and other influential people. The lists were sent to the approval of the Emperor, being presented, twice a year: December 2, the anniversary of the Emperor; March 14 or 25, respectively, the anniversary of the Empress and the anniversary of the oath of the Constitution of the Brazilian Empire of 1824—the first Brazilian constitutional charter.
Some Brazilian nobles were given the distinction "with grandeeship," which allowed them to use in their coat of arms the crown of the next higher title—for example, a baron could wear the viscount's coronet on his coat of arms. Also, a Grandee of the Empire enjoyed other privileges and precedence that holders of the next superior title enjoyed. The grandeeship was conferred on 135 barons, who used the viscomital coronet in their coats of arms, and 146 viscounts, who used the comital coronet.
Registration of nobility
All records of the nobility were made in the books of the Office of Nobility and Knighthood until 1848, when they disappeared under unexplained circumstances. At the time, they were the responsibility of Possidonio da Fonseca Costa, the then-King of Arms, which greatly hindered the registration of noble titles granted during the First Reign of the Empire. Luis Aleixo Boulanger, his successor, sought to recover part of this documentation, producing a single book with part of the first generation of the Brazilian nobility.
Throughout the entirety of the Empire's existence, 1,211 titles of nobility were created: 3 dukes, 47 marquises, 51 counts, 235 viscounts and 875 barons. The total number of recipients, however, was lower—around 980—as many received more than one title. These numbers are not entirely accurate, as there are doubts about the validity and even the existence of some titles. Much of this doubt stems from the loss of some of the records of the Office of Nobility and Knighthood during the First Reign.
Symbols
Royal titles
Noble titles
Famous nobles
Dukes
Auguste de Beauharnais, Duke of Santa Cruz, Prince Consort of Portugal
Luís Alves de Lima e Silva, Duke of Caxias, military general
Isabel Maria de Alcântara, Duchess of Goiás, illegitimate daughter of Emperor Pedro I
Marquesses
Domitila de Castro do Canto e Melo, Marchioness of Santos
Thomas Cochrane, 10th Earl of Dundonald, 1st Marquess of Maranhão
Honório Hermeto Carneiro Leão, Marquis of Paraná
Manuel Luís Osório, Marquis of Erval
Counts
Manuel Marques de Sousa, Count of Porto Alegre
Viscounts
Irineu Evangelista de Sousa, Viscount of Mauá
José Paranhos, Viscount of Rio Branco
Joaquim José Inácio, Viscount of Inhaúma
Barons
José Maria da Silva Paranhos Júnior, Baron of Rio Branco
Henrique Hermeto Carneiro Leão, Baron of Paraná
Gregório Francisco de Miranda, Baron of Abadia (1795 - 1850)
Maria Izabel Cardoso Gusmão, baronese of Abadia
References
Literature
Schwarcz, Lilia Moritz. As barbas do Imperador: D. Pedro II, um monarca nos trópicos. 2. Ed. São Paulo: Companhia das Letras, 1998.
Category:Social class in Brazil
Category:Titles of nobility in the Americas
Category:Nobility of the Americas |
Q:
Why won't upcast to concrete type of another common interface
Why can't you upcast to a different concrete type of another common interface. I've created this example in linqpad. Now I can understand if you had different properties between the two classes that an up cast would fail because it couldn't complete the object. But in this Scenario I don't see why the upcast would fail.
void Main()
{
ICommon test = new ConcreteA();
((ConcreteA)test).a.Dump();
// this errors with: Unable to cast object of type 'ConcreteA' to type 'ConcreteB'.
((ConcreteB)test).a.Dump();
}
public interface ICommon
{
string a {get; }
}
public class ConcreteA : ICommon
{
public string a {
get{ return "Concrete A"; }
}
}
public class ConcreteB : ICommon
{
public string a {
get{ return "Concrete B"; }
}
}
Shouldn't the compiler be able to treat this as if you were casting from an double to an int, if a double was too big for an int it would throw an exception but if the cast was possible the compiler would do it. Why doesn't the compiler try to load the ConcreteA as a ConcreteB and if there were extra properties in the ConcreteB that it couldn't figure out then it would throw.
A:
Since ConcreteA knows nothing about ConcreteB (in your case, because they may have different implementation for property a), I suggest you implement explicit operator for ConcreteB like this:
public class ConcreteA
{
/* rest of your code ... */
public static explicit operator ConcreteB(ConcreteA instance)
{
// implement converting from ConcreteA to ConcreteB
}
}
For more info about explicit operator: https://msdn.microsoft.com/en-us/library/xhbhezf4.aspx
|
Muscle activity changes in spasmodic torticollis after botulinum toxin treatment.
We assessed electromyographic (EMG) activity in neck muscles before and after botulinum toxin injections in 28 patients with spasmodic torticollis (ST) to investigate possible changes in muscle activation after treatment. A six-channel EMG with surface electrodes was used to record activity of sternocleiodomastoid, trapezius and splenius capitis bilaterally. Objective benefit (>25% reduction in Tsui's score) occurred in 22 patients (78%). Of the 168 muscles studied before botulinum toxin injections, 90 presented EMG activity. Sixty-eight of these muscles were injected and a decrease in EMG activity occurred in 44 (65%) of them. A decrease in EMG activity was also detected in 15 (68%) of those which were not injected. On the other hand, 70 of the 78 muscles without pre-botulinum toxin EMG activity were not injected. However, after treatment, EMG activity increased in 37 (52%) of these muscles. These changes involved 18 patients and occurred without concomitant change in the main direction of head deviation despite the improvement observed in most cases. These results suggest that in ST head turning results from an abnormal central motor program which results in non-specific neck muscle activation. |
Laidley North, Queensland
Laidley North is a rural locality in the Lockyer Valley Region, Queensland, Australia. In the , Laidley North had a population of 408 people.
History
The locality was named on 3 June 1994. Its name is derived from the town name of Laidley, which itself derives from the naming of Laidleys Plain by explorer Allan Cunningham after James Laidley New South Wales Deputy Commissary General.
Laidley North Mixed State School opened on 1 April 1889. In 1897 the name was changed to Laidley North State School. A secondary department was added in 1964 to 1984 (as a separate Laidley State High School opened in 1985). The school closed on 12 December 1998.
References
Category:Lockyer Valley Region
Category:Localities in Queensland |
Cover art, photos and screenshots
Description:Fez (stylized as FEZ) is a 2012 puzzle platform game developed by indie developer Polytron Corporation and produced by Polytron, Trapdoor, and Microsoft Studios. It is a 2D game set in a 3D world, as the two-dimensional player-character receives a fez that reveals a third dimension and consequently tears the fabric of his universe. Fez's puzzles are built around the core mechanic of rotating between four 2D views of a 3D space, as four sides around a cube, where the environment realigns between views to create new paths.
The game was an "underdog darling of the indie game scene" during its high-profile and protracteFez (stylized as FEZ) is a 2012 puzzle platform game developed by indie developer Polytron Corporation and produced by Polytron, Trapdoor, and Microsoft Studios. It is a 2D game set in a 3D world, as the two-dimensional player-character receives a fez that reveals a third dimension and consequently tears the fabric of his universe. Fez's puzzles are built around the core mechanic of rotating between four 2D views of a 3D space, as four sides around a cube, where the environment realigns between views to create new paths.
The game was an "underdog darling of the indie game scene" during its high-profile and protracted five-year development cycle. Fez designer and Polytron founder Phil Fish received celebrity for his outspoken public persona and prominence in the 2012 documentary Indie Game: The Movie, which followed the game's final stages of development and Polytron's related legal issues. The game was released as a yearlong Xbox Live Arcade exclusive on April 13, 2012 to critical acclaim, and was later ported to other platforms.... (more)(less) |
Bloodstain pattern analysis in a case of fatal varicose vein rupture.
Rupture of a varicose vein is a rare cause of sudden death. It occurs when the failure of venous valves causes an increase in venous pressure great enough to provoke rupture of the blood vessel. When it does happen, the victim is often found surrounded by a pool of blood, and the examination of the scene can mislead the forensic team to think of violent death. Until now, the bloodstain patterns in these fatal cases have not been described. An examination of the bloodstain pattern in a case of fatal varicose vein rupture in an 84-year-old man is here reported. |
MEMPHIS, Tenn. — Watch "Fifty Shades of Grey" with your children. That just might offer the level of discomfort that Memphis Grizzlies center Marc Gasol felt following Tuesday night’s win against Dallas.
Coming off a two-point performance in a win against Miami on Sunday, the goal for Gasol was to get going early. He scored 14 points in the first quarter and finished with 30, the fourth time this season with 30 or more. In the waning seconds, he scored his final two on a pair of throw-away free throws while the chants rained down at FedExForum: "MVP, MVP, MVP."
Asked about it, the 7-foot-1 Spaniard — who makes a living performing in front of thousands and facing multiple microphones and cameras everywhere he turns — was visibly uncomfortable.
"It was … it was fine," Gasol said.
That’s not Gasol failing to appreciating the chant. That’s Gasol not wanting to steal a single second of glory for what has thus far been a buzzing start for the 17-4 Grizzlies. Asked again did it make him feel good: "Um, no," Gasol stuttered, visibly ready for the next question, any question.
Surely it made him feel good, but that’s an assumption one can’t make about Gasol’s unselfish, business-like approach. If it did tingle him a bit, he’d never admit it.
"I mean, overwhelming, probably," Gasol said. "I don’t know what to say."
Whew, it was over. A humble gratefulness. The interview continued with questions about the game — not his personal game because Grizzlies writers typically know he’s not going to talk about it — and questions about how he and Jon Leuer held Dirk Nowitzki to 11 points. The first word about defending Nowitzki was, "we."
Just imagine if Gasol keeps his current pace. Right now, he is averaging a career-best 19.5 points per game, nearly five more points than his highest previous average, 14.6 in three different seasons. Commonly referred to as maybe the best big-man passer in the NBA, he is averaging 3.8 assists per game, behind only Joakim Noah’s 4.5 among centers. He is averaging eight rebounds per game, 1.5 blocks and a steal and shooting 50 percent from the field and a career-best 85 percent from the free throw line.
If you didn’t know that, Gasol won’t tell you. Grizzlies coach Dave Joerger was asked if Gasol ever discusses his personal stats away from the media.
"No," he said. "I hardly ever look at it myself."
He doesn’t have to. Joerger knows what he’s getting. When Gasol scored only eight points in November against the Lakers, he also logged nine assists. When he scored two this week against the Heat, seven assists. Gasol’s PER is 11th in the league at 23.48. When he was 1 of 6 shooting against Miami, SportVU said the Grizzlies scored 30 points off of the 22 screens he set.
Gasol has become a quiet superstar. Even if casual fans don’t, the Grizzlies know his value. They also know that without him, they posted a 10-13 record last season. They were 40-19 when he played. So Gasol, who missed those 23 games with an MCL sprain, sent tremors through Memphis when he left the game in Houston a week ago. Turns out it was a bone bruise on his right knee.
Gasol was the NBA’s Defensive Player of the Year two seasons ago and talked in his ceremony about a greater desire to win playoff games, at the time down two games to none to the Clippers in a first-round series. That season, he averaged 1.7 blocks per game and Memphis was the league’s stingiest defense, allowing 89.3 points per game.
Fast forward and Memphis still allows the fewest points in the league (94 per game). But this team also scores 101 points per game, 15th in the NBA. Two years ago, Memphis’s 93.4 scoring average ranked 26th in the league.
Getting to the rim is tough with Gasol and power forward Zach Randolph down there. And the Grizzlies have added wing scorers, sure, but it’s no coincidence Gasol’s more aggressive approach is one (big) reason for the team’s offensive surge, too.
"He’s opened up stuff for a lot of other guys just by being so aggressive offensively," Joerger said. "He plays both ends of the floor and he cares about winning."
He is an opposing nightmare on each end, the team’s top floor-spacer and defender, pick and roll and rim. He’s a game-changer.
And a free agent in 2015. |
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WILMINGTON — It was just 12 hours after the Bruins dropped a 5-4 overtime decision to the Flyers in Game 4 of their Eastern Conference semifinal series in Philadelphia, and there they were at practice at Ristuccia Arena yesterday morning.
Well, there he was.
Dennis Seidenberg was the only Bruin on the ice, going through a workout with strength and conditioning coach John Whitesides.
It was the first skate for Seidenberg since the 28-year-old defenseman sustained a torn tendon in his left forearm April 3 in a game against Toronto. Seidenberg, who needed surgery to repair the damage, has missed 14 games and he’s aching to get back.
“It’s been tough the whole time I’ve been watching, four weeks,’’ he said. “I hate it. I’d definitely like to play.’’
Seidenberg said his wrist feels good and he is healing on schedule — though no schedule is fast enough for him.
The Bruins lead the best-of-seven series, three games to one, and though they lost the chance to sweep in Philadelphia, the battered crew gets two days of rest before Game 5 tomorrow night at TD Garden, a chance to wrap it up in front of the home crowd.
McQuaid day to day
Adam McQuaid, the replacement defenseman who had to be replaced himself after suffering a “lower-body injury’’ in Game 3, missed all of Game 4. At Ristuccia yesterday to receive medical treatment, he said his status is day to day.
“I went into the boards kind of awkwardly,’’ said McQuaid, whose playoff beard is now longer than his ice time.
After his encounter with the endboards at Wachovia Center, McQuaid ended up with only 1 minute 49 seconds of ice time in Game 3.
“I was saying to some of the guys, ‘It was kind of a nightmarish game,’ ’’ he said. “Obviously, I’m disappointed with how it went.
“Usually when you get the bumps and bruises kind of things when you’re playing, it comes around. This time it just didn’t.’’
Toughest critic
Defenseman Mark Stuart played Friday for the first time since Jan. 30, when he suffered a finger injury, and while his physical game seemed in fine form, after the loss he castigated himself for several mental errors. Shawn Thornton was having none of it. “He’s a big man, he’s a competitive man,’’ said Thornton. “I think he’s a little too hard on himself sometimes. He’s a very, very competitive person. He’ll be ready to go for the next one, I’m sure.’’ |
Defining the steps one must complete to achieve one's goals is the first step in many higher endeavors. When the endeavor is achieving a certain level of security on an IBM i server or any other kind of IT system, the goals are put down on paper in the form of a detailed security policy. For organizations that are looking to bolster their IBM i security practices but don't know where to start, PowerTech provides a free, downloadable IBM i security policy template to get them going.
It is hard to believe, but many IBM i shops today don't have security policies, which, unfortunately, is just one of many security failings at IBM i shops. These organizations are flying blind by the seat of their administrator's pants, hoping they don't have a security problem (presuming they could detect it in the first place). Without a security policy to go by, it's very difficult for an organization to practice any kind of rigor in pursuit of higher security. In other words, a security policy is the foundation block of all security practices, and without it, no security structures can be built on top of it.
That's not to say every company needs a Fort Knox-like security policy. Each organization's security policy is a unique reflection of the risks they are willing to take. A small company with just a dozen users accessing an IBM i server with no ODBC, FTP, or HTTP links outside the firewall will require a much simpler security policy than a national retailer handling billions of dollars of electronic transactions, which must adhere to the strict PCI DSS requirements.
But any organization that values its data--and its relationship with customers who are represented by that data--should have, at the very least, a semblance of a security policy. For IBM i shops that don't, PowerTech's "OS/400 Security Policy" provides a good place to start.
The 13-page security policy is broken down into various sections, such as physical security, data access security, user profile security, etc. Many of the entries are no-brainers, such the computer must be located in a secure room. It seems simple to say, but without a lock on the office or computer room door, no security can be achieved.
PowerTech's policy provides examples for how IBM i should be configured for security. Some of the recommendations are quite detailed, and some administrators may choose to have stricter or more lenient settings, depending on their particular needs. The document does not provide a complete security policy, but is a starting point for developing a custom security policy.
PowerTech will be updating the policy in the near future, and welcomes suggestions and submissions from the IBM i community, according to an August blog posting by PowerTech's director of security technologies Robin Tatam.
"This popular document will continue to be a free resource to the IBM i security community, and we invite anyone to download, edit, and return the changes to us for possible (and credited) inclusion in a future edition," Tatam writes.
You can obtain PowerTech's OS/400 Security Policy as a free PDF download from its website at www.powertech.com. |
Role of endothelium-derived relaxing factor in the in vivo renal vascular action of adenosine in dogs.
Intrarenal infusion of adenosine induces transient renal vasoconstriction followed by sustained renal vasodilation. The purpose of this study was to elucidate the role of endothelium-derived relaxing factor (EDRF) in renal hemodynamic actions of adenosine in anesthetized dogs. Intrarenal arterial infusion (i.r.a.) of EDRF synthesis inhibitors, L-NG-monomethyl-arginine (160 micrograms/kg/min) and L-NG-nitro-arginine (80 micrograms/kg/min), attenuated acetylcholine-induced increases in renal blood flow and renal vascular resistance was increased. Renal vasoconstriction elicited by adenosine (100 nmol/min i.r.a.) was potentiated and the duration was prolonged by pretreatment with either EDRF synthesis inhibitor. Adenosine infusion significantly decreased glomerular filtration rate (GFR) by more than 30% in the presence of EDRF inhibitors, whereas GFR remained unchanged by adenosine in the absence of EDRF synthesis inhibitors. L-arginine (2 mg/kg/min i.r.a.) significantly reversed the potentiation of adenosine-induced renal vasoconstriction and adenosine-induced reduction in GFR elicited by pretreatment with EDRF synthesis inhibitors. On the other hand, the adenosine A2 selective agonist, CGS 21680C (0.37 nmol/kg/min i.r.a), elicited monophasic renal vasodilation and this effect on renal blood flow was unaffected by EDRF inhibitor. These results suggest that arginine-derived EDRF is involved in the renal vascular action of adenosine. In the present experimental setting, we obtained no evidence for the interaction between arginine-derived EDRF and CGS 21680C-activated A2 adenosine receptor in renal vascular beds. |
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{Lighter} Fresh Raspberry Squares
Want to know what summer tastes like? Bite into one of these squares. The berry cousin of lemon bars, they’re bursting with fresh, juicy and slightly tart raspberries, so they’re fruity and sweet, but not overly so. The use of a little cornstarch in the crust makes it super crisp (also allowing to reduce the amount of butter used in the recipe), and pecans contribute to balance out the bright flavor of the fruit. The filling is almost all raspberry, and again, a little cornstarch is used to thicken the mixture and allow it to set instead of additional egg yolks and butter, letting the fruit shine and making the dessert almost sinless. I like to serve the squares topped with additional fresh raspberries, but they’re absolutely fantastic on their own too.
Preheat oven to 350°F [175°C]. Line an 8-inch [20-cm] square baking pan with parchment paper, letting it overhang on two sides.
For the crust: Combine flour, ground pecan nuts, powdered (confectioners’) sugar, cornstarch and ¼ teaspoon salt in a medium bowl. Add oil and butter or dairy free spread. Using a fork or your fingertips, blend into the flour mixture until evenly combined. The mixture should be a little crumbly. Firmly press the dough into the prepared pan. Bake until just barely beginning to brown around the edges, 15 to 20 minutes.
For the filling: While the crust is baking, combine raspberries and water in a medium saucepan. Cook over high heat, stirring frequently, until the fruit is very soft and mostly broken down, 4 to 6 minutes. Pour through a fine-mesh sieve into a medium bowl, pressing on the solids to extract all the liquid. Discard the seeds. Pour the strained juice into a measuring cup. You need 1 cup strained juice; remove any extra or add a little water if you are short. Stir in lemon juice.
Whisk granulated sugar, cornstarch and a pinch of salt in a medium bowl until well combined. Whisk in eggs. Stir in the juice mixture, pouring it slowly into the egg mixture while beating constantly. Pour the filling over the crust.
Bake until just set, 15 to 20 minutes. (The center should still be a little jiggly—it will firm up as it cools.) Let cool to room temperature in the pan on a wire rack, about 1 ½ hours. Gently slide a sharp knife along the edges of the pan that are not covered with parchment paper, and lift out of the pan all in one piece using the edges of the parchment paper. Cut into 9 squares.
Dust with powdered (confectioners’) sugar and garnish with fresh raspberries, if desired, just before serving. Keep remaining squares in an airtight container (in a single layer) in the fridge and eat within 3 days.
3 Responses to {Lighter} Fresh Raspberry Squares
I made 2 trays of these for a charity “cake bake” at work.They went within minutes. I made a few little changes and swapped the Raspberries for English Strawberries as they were right in peak season. I also added a little double cream into the mix. So there you go… English summer on a plate…The Wimbledon Strawberries and Cream cake…Awesome and thanks very much. Alan |
Something is really wrong somewhere. All of yesterday we read in the newspapers and watched on TV government of India expressing its steely resolve to prevent the auction of Mahatma Gandhis’s memorabilia. Even Prime Minister Manmohan Singh’s office was supposed to be keeping a close watch on the happenings in New York and Los Angeles- where the auction took place. Today’s morning newspapers joyfully were announcing how these efforts had paid off and the auction would not take place.
News coming in from Los Angeles told a different story though. Gandhi’s iconic belongings that came under the gavel were picked up from the proceeds of liquor money put up by United Breweries Chairman Vijay Mallya. He snapped them up for a whopping $ 1.8 million. Gandhi, who all his fight championed prohibition and taught his followers about the evils of liquor consumption, would be turning in his grave with the way his prized legacy was saved by the beer baron. One wonders when poor Gandhi’s loin cloth will be bid!
Congress led government should be ashamed that they allowed a teetotaler, prohibitionist Mahatma’s considerable legacy to be sullied by someone who preaches values that are diametrically opposite. American film maker and collector, James Otis, who owned these antiques, would go laughing to the bank and so would his PR agency that kicked up such a fabulous global campaign about how Gandhi’s belongings had to be rescued by the Indian government.
Television images show that there were other bidders too in Los Angeles. Sant Singh Chatwal, an hotelier with a dubious past, was also present there. He had promised to go up to $ 1 million to pick up Gandhi’s steel framed glasses and zenith watch. Chatwal and Mallya, we learns, represented “plan B” for the Indian government if efforts to stop the auction did not work.It is not clear under what circumstances Mallya put up the money to clinch the bid, but he has given an impression of being cash strapped. Not, too, long ago he had sought relief from the government for his recession hit airline. His company had claimed that they did not have the money to repay landing fees to Airport Authority of India. The cheques that were given to the government company were undated and unsigned. One believes that that Mallya’s company has made amends since then.
The beer baron’s “service to the nation” is unlikely to go unrewarded. It will be interesting to see how the hedonist "King of Good Times", Mallya spins his Gandhian acquisition. |
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