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Alignment-Lab-AI
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EN_B00000_S05963_W000008
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4157, "duration": 6.326, "id": "EN_B00000_S05963_W000008", "language": "en", "speaker": "EN_B00000_S05963", "text": " As well as impressing your attendings on round because attendings were always, uh, really.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000008.mp3" }
EN_B00000_S05963_W000008.mp3
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EN_B00000_S05963_W000009
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3737, "duration": 6.401, "id": "EN_B00000_S05963_W000009", "language": "en", "speaker": "EN_B00000_S05963", "text": " Excited when medical students and residents have a good formulaic way about going about patient care.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000009.mp3" }
EN_B00000_S05963_W000009.mp3
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EN_B00000_S05963_W000010
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4165, "duration": 3.65, "id": "EN_B00000_S05963_W000010", "language": "en", "speaker": "EN_B00000_S05963", "text": " So, uh, thank you very much in advance for your consideration.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000010.mp3" }
EN_B00000_S05963_W000010.mp3
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EN_B00000_S05963_W000011
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3362, "duration": 11.1, "id": "EN_B00000_S05963_W000011", "language": "en", "speaker": "EN_B00000_S05963", "text": " So we're going to talk about two blistering skin disorders, Pemphigus vulgaris and Bullis pemphigoid. Uh, we'll briefly talk about traumatic blisters, certainly the most common cause of blisters.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000011.mp3" }
EN_B00000_S05963_W000011.mp3
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EN_B00000_S05963_W000012
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2611, "duration": 14.117, "id": "EN_B00000_S05963_W000012", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, there are some other disorders that involve blisters, but they, uh, are going to be covered in future lectures because they are fairly unique in and of themselves and I just think that they'll, they'll be better, uh, covered under different categories.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000012.mp3" }
EN_B00000_S05963_W000012.mp3
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EN_B00000_S05963_W000013
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0341, "duration": 7.011, "id": "EN_B00000_S05963_W000013", "language": "en", "speaker": "EN_B00000_S05963", "text": " So blistering skin disorders involve blisters, and the medical name for a blister is Ebola, plural bully.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000013.mp3" }
EN_B00000_S05963_W000013.mp3
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EN_B00000_S05963_W000014
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1529, "duration": 14.55, "id": "EN_B00000_S05963_W000014", "language": "en", "speaker": "EN_B00000_S05963", "text": " It's due to a loss of cohesion either within a layer of the epidermis or between layers of the skin, namely between the dermis and epidermis. Uh, and this results in a filling of the potential space with fluid.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000014.mp3" }
EN_B00000_S05963_W000014.mp3
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EN_B00000_S05963_W000015
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3889, "duration": 19.966, "id": "EN_B00000_S05963_W000015", "language": "en", "speaker": "EN_B00000_S05963", "text": " Remember that bullae are greater than one centimeter in diameter, whereas vesicles are the same exact pathologic process. They're just less than one centimeter in diameter. So those are, uh, some naming conventions. Uh, bullae are going to be things that we're going to talk about here. Vesicles are what you would see in like herpes, for instance.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000015.mp3" }
EN_B00000_S05963_W000015.mp3
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EN_B00000_S05963_W000016
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3772, "duration": 15.552, "id": "EN_B00000_S05963_W000016", "language": "en", "speaker": "EN_B00000_S05963", "text": " Bully are commonly subdivided into the location of separation. So we have epidermal and subepidermal blisters. Epidermal blisters are due to separation of the layers within the dermis. These blisters for that reason, because they have a thinner top,", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000016.mp3" }
EN_B00000_S05963_W000016.mp3
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EN_B00000_S05963_W000017
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3189, "duration": 17.215, "id": "EN_B00000_S05963_W000017", "language": "en", "speaker": "EN_B00000_S05963", "text": " They're gonna be flaccid and more fragile. Whereas sub-epidermal blisters are due to separation of the epidermis and the dermis at the basement membrane. And so because they have a thicker roof to the top of them, a thicker dome, you can think of it, these buoys are tense and stronger.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000017.mp3" }
EN_B00000_S05963_W000017.mp3
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EN_B00000_S05963_W000018
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3111, "duration": 10.56, "id": "EN_B00000_S05963_W000018", "language": "en", "speaker": "EN_B00000_S05963", "text": " Blisters can be due to autoimmune conditions, as we're gonna talk about here, or they could be related to physical forces like trauma and friction and heat, burns, uh, and so forth.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000018.mp3" }
EN_B00000_S05963_W000018.mp3
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EN_B00000_S05963_W000019
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2549, "duration": 6.129, "id": "EN_B00000_S05963_W000019", "language": "en", "speaker": "EN_B00000_S05963", "text": " Nicole's key sign is something you should be aware of. I go over it in that intro to dermatology talk and", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000019.mp3" }
EN_B00000_S05963_W000019.mp3
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EN_B00000_S05963_W000020
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2223, "duration": 7.793, "id": "EN_B00000_S05963_W000020", "language": "en", "speaker": "EN_B00000_S05963", "text": " Nikolsky sign is basically you take the blister, you rub along the side of it, and you see if you can grow the blister.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000020.mp3" }
EN_B00000_S05963_W000020.mp3
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EN_B00000_S05963_W000021
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1634, "duration": 8.133, "id": "EN_B00000_S05963_W000021", "language": "en", "speaker": "EN_B00000_S05963", "text": " That's called Nikolsky Positive. And if you can't, it's Nikolsky Negative. And that helps you distinguish epidermal blisters from subepidermal blisters.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000021.mp3" }
EN_B00000_S05963_W000021.mp3
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EN_B00000_S05963_W000022
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1884, "duration": 12.394, "id": "EN_B00000_S05963_W000022", "language": "en", "speaker": "EN_B00000_S05963", "text": " So this is a cartoon of the skin denoting the epithelial cell junctions. The two we're really concerned about for this talk are the desmosomes which link keratinocytes and the", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000022.mp3" }
EN_B00000_S05963_W000022.mp3
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EN_B00000_S05963_W000023
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2697, "duration": 4.006, "id": "EN_B00000_S05963_W000023", "language": "en", "speaker": "EN_B00000_S05963", "text": " Hemidesmosome, which links keratinocytes to the basement membrane.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000023.mp3" }
EN_B00000_S05963_W000023.mp3
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EN_B00000_S05963_W000024
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.345, "duration": 10.628, "id": "EN_B00000_S05963_W000024", "language": "en", "speaker": "EN_B00000_S05963", "text": " Pemphigus vulgaris is the most common variant of Pemphigus. There's a lot of different types of Pemphigus, but Pemphigus vulgaris is the most common type, but it's not very common overall.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000024.mp3" }
EN_B00000_S05963_W000024.mp3
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EN_B00000_S05963_W000025
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1069, "duration": 8.156, "id": "EN_B00000_S05963_W000025", "language": "en", "speaker": "EN_B00000_S05963", "text": " It's due to infiltration of IgG, immunoglobulin G, into the epidermis, which targets desmosomes that link keratinocytes. And so,", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000025.mp3" }
EN_B00000_S05963_W000025.mp3
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EN_B00000_S05963_W000026
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3904, "duration": 13.211, "id": "EN_B00000_S05963_W000026", "language": "en", "speaker": "EN_B00000_S05963", "text": " Because it targets desmosomes, destroys the desmosomes, the keratinocytes are going to separate and you're going to have a loss of cohesion. We call that loss of cohesion acantholysis or acantholysis, however you want to pronounce it.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000026.mp3" }
EN_B00000_S05963_W000026.mp3
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EN_B00000_S05963_W000027
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1336, "duration": 12.139, "id": "EN_B00000_S05963_W000027", "language": "en", "speaker": "EN_B00000_S05963", "text": " The precise protein that's targeted in the desmosomes is desmoglu- desmoglian 1 or desmoglian 3. You'll want to know this if you're taking step 1. If you're taking step 2 or 3, it's really not relevant information.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000027.mp3" }
EN_B00000_S05963_W000027.mp3
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EN_B00000_S05963_W000028
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2257, "duration": 13.752, "id": "EN_B00000_S05963_W000028", "language": "en", "speaker": "EN_B00000_S05963", "text": " As I said, it's rare, about 1 to 10 per 100,000, but it's much more common in individuals of Jewish, Middle Eastern, and Mediterranean descent. As a matter of fact, I read somewhere that the, the prevalence in", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000028.mp3" }
EN_B00000_S05963_W000028.mp3
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EN_B00000_S05963_W000029
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.422, "duration": 11.205, "id": "EN_B00000_S05963_W000029", "language": "en", "speaker": "EN_B00000_S05963", "text": " Jerusalem is actually 100 per 100,000. So, uh, quite a significant difference. The incidence obviously then varies by region. Most cases are diagnosed in middle age.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000029.mp3" }
EN_B00000_S05963_W000029.mp3
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EN_B00000_S05963_W000030
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3868, "duration": 8.048, "id": "EN_B00000_S05963_W000030", "language": "en", "speaker": "EN_B00000_S05963", "text": " And the skin. And typically when you see this, it's going to start in the mouth and then it will start to occur elsewhere on the body.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000030.mp3" }
EN_B00000_S05963_W000030.mp3
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EN_B00000_S05963_W000031
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2008, "duration": 14.245, "id": "EN_B00000_S05963_W000031", "language": "en", "speaker": "EN_B00000_S05963", "text": " It's typically widespread at the later stages and more progressed stages of the disease. The palms and soles are usually spared, and that's an important distinction from the next disease we're going to talk about, some of the other diseases.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000031.mp3" }
EN_B00000_S05963_W000031.mp3
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EN_B00000_S05963_W000032
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2772, "duration": 7.335, "id": "EN_B00000_S05963_W000032", "language": "en", "speaker": "EN_B00000_S05963", "text": " Because the blisters are fragile, a lot of times when you see it, it's just gonna look like erosion. So it's not gonna look like blisters. The blisters will have already popped.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000032.mp3" }
EN_B00000_S05963_W000032.mp3
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EN_B00000_S05963_W000033
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0917, "duration": 5.077, "id": "EN_B00000_S05963_W000033", "language": "en", "speaker": "EN_B00000_S05963", "text": " And, uh, and so it'll be more of an erosion in appearance, but you may see some blisters too.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000033.mp3" }
EN_B00000_S05963_W000033.mp3
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EN_B00000_S05963_W000034
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1824, "duration": 14.364, "id": "EN_B00000_S05963_W000034", "language": "en", "speaker": "EN_B00000_S05963", "text": " Gross appearance, you have painful flaccid blisters of the mucous membrane and skin. Usually they're eroded. The erosions can coincide with the blisters. If you do see the blisters, you'll want to do a Nikolsky test and they'll be Nikolsky positive.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000034.mp3" }
EN_B00000_S05963_W000034.mp3
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EN_B00000_S05963_W000035
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3352, "duration": 6.46, "id": "EN_B00000_S05963_W000035", "language": "en", "speaker": "EN_B00000_S05963", "text": " So this is an example of Pemphigus vulgaris on the mucus membrane of the mouth.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000035.mp3" }
EN_B00000_S05963_W000035.mp3
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EN_B00000_S05963_W000036
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3087, "duration": 13.004, "id": "EN_B00000_S05963_W000036", "language": "en", "speaker": "EN_B00000_S05963", "text": " Notice that this is eroded, so you don't see the blister and it's very easy for these blisters to erode because there's a lot of friction in the mouth and, uh, you know, the teeth can rub up against it and remember they're very weak blisters.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000036.mp3" }
EN_B00000_S05963_W000036.mp3
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EN_B00000_S05963_W000037
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0756, "duration": 3.99, "id": "EN_B00000_S05963_W000037", "language": "en", "speaker": "EN_B00000_S05963", "text": " This is an intact blister on the tongue. This is a really big blister here.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000037.mp3" }
EN_B00000_S05963_W000037.mp3
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EN_B00000_S05963_W000038
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3438, "duration": 12.87, "id": "EN_B00000_S05963_W000038", "language": "en", "speaker": "EN_B00000_S05963", "text": " And you can see here that it can spread, uh, to the trunk. So, uh, again, you don't really see any, uh, current blisters. Uhm, but you'll wanna look for one because that's where you're gonna biopsy. You wanna biopsy on the blister.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000038.mp3" }
EN_B00000_S05963_W000038.mp3
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EN_B00000_S05963_W000039
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.42, "duration": 17.827, "id": "EN_B00000_S05963_W000039", "language": "en", "speaker": "EN_B00000_S05963", "text": " So here you do actually see some blisters. And notice that, uh, that you have different stages of healing. So you've got some eroded blisters. You've got active blisters. Uh, some can be filled with serum. Others, uh, can have more of a bloody, uh, uh, filling to them.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000039.mp3" }
EN_B00000_S05963_W000039.mp3
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EN_B00000_S05963_W000040
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1956, "duration": 5.161, "id": "EN_B00000_S05963_W000040", "language": "en", "speaker": "EN_B00000_S05963", "text": " Or at least, uh, what you see underneath the blister is, uh, red tissue.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000040.mp3" }
EN_B00000_S05963_W000040.mp3
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EN_B00000_S05963_W000041
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2561, "duration": 3.668, "id": "EN_B00000_S05963_W000041", "language": "en", "speaker": "EN_B00000_S05963", "text": " The microscopic findings, you'll see a super basal or cleft.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000041.mp3" }
EN_B00000_S05963_W000041.mp3
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EN_B00000_S05963_W000042
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4289, "duration": 14.211, "id": "EN_B00000_S05963_W000042", "language": "en", "speaker": "EN_B00000_S05963", "text": " I'm gonna show you a picture of that of course. Uh, you may also see dermal inflammatory cell infiltrate with eosinophils. Remember those are those pink, uh, white blood cells.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000042.mp3" }
EN_B00000_S05963_W000042.mp3
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EN_B00000_S05963_W000043
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4841, "duration": 14.588, "id": "EN_B00000_S05963_W000043", "language": "en", "speaker": "EN_B00000_S05963", "text": " Direct immunofluorescence is really important to understand because the USMLE likes to show you this one. Uh, they'll show you a picture of this and they'll ask you in the answer choices, pemphigus vulgaris and bullis pemphigus will be two answer choices and you'll need to know how to distinguish them.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000043.mp3" }
EN_B00000_S05963_W000043.mp3
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EN_B00000_S05963_W000044
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3429, "duration": 12.583, "id": "EN_B00000_S05963_W000044", "language": "en", "speaker": "EN_B00000_S05963", "text": " You'll see IgG and C3 deposits in the pattern of a broad linear net-like band. And of course it's going to be in the epidermal layer because this targets desmosomes of the keratinocytes.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000044.mp3" }
EN_B00000_S05963_W000044.mp3
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EN_B00000_S05963_W000045
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3512, "duration": 5.339, "id": "EN_B00000_S05963_W000045", "language": "en", "speaker": "EN_B00000_S05963", "text": " Okay, so this is that tomb stoning, it's just basically, uh, basal cells.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000045.mp3" }
EN_B00000_S05963_W000045.mp3
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EN_B00000_S05963_W000046
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3637, "duration": 15.804, "id": "EN_B00000_S05963_W000046", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, and, uh, notice that you have here your blister cavity. Uh, notice that the basement membrane is intact. That's this sort of fuchsia-like line underneath these basal cells. The stratum basale. Remember the stratum basale is just one layer thick.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000046.mp3" }
EN_B00000_S05963_W000046.mp3
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EN_B00000_S05963_W000047
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0748, "duration": 3.379, "id": "EN_B00000_S05963_W000047", "language": "en", "speaker": "EN_B00000_S05963", "text": " You don't see much inflammatory, uh, exudate here.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000047.mp3" }
EN_B00000_S05963_W000047.mp3
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EN_B00000_S05963_W000048
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1769, "duration": 6.204, "id": "EN_B00000_S05963_W000048", "language": "en", "speaker": "EN_B00000_S05963", "text": " Okay, again you see here that the, uh, the basal layer is intact, the basement membrane is intact.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000048.mp3" }
EN_B00000_S05963_W000048.mp3
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EN_B00000_S05963_W000049
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3751, "duration": 17.832, "id": "EN_B00000_S05963_W000049", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, you have what are called here, uh, acanthocytes, that's just cells that have, uh, cleaved away from each other, keratinocytes have cleaved away from each other, uh, due to the loss of, uh, of connective integrity. Uhm, and notice that this might be an eosinophil here or a red blood cell, I can't really tell.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000049.mp3" }
EN_B00000_S05963_W000049.mp3
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EN_B00000_S05963_W000050
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3472, "duration": 15.874, "id": "EN_B00000_S05963_W000050", "language": "en", "speaker": "EN_B00000_S05963", "text": " This is that tomb stoning again. All the tomb stoning is, what it means is that you see basal cells detached from the rest of the epidermis. So they look like tombs, because remember they're kind of, uh, the, the cells of the stratum basale are kind of, uh, columnar in shape.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000050.mp3" }
EN_B00000_S05963_W000050.mp3
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EN_B00000_S05963_W000051
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1349, "duration": 5.993, "id": "EN_B00000_S05963_W000051", "language": "en", "speaker": "EN_B00000_S05963", "text": " Again, notice the basement membrane is intact. That's this kind of pinkish fuchsia layer underneath the stratum base alley.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000051.mp3" }
EN_B00000_S05963_W000051.mp3
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EN_B00000_S05963_W000052
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3669, "duration": 11.516, "id": "EN_B00000_S05963_W000052", "language": "en", "speaker": "EN_B00000_S05963", "text": " This is immunofluorescence. So, uh, immunofluorescence, if it stains positive, it's going to be a lighter neon green color, whereas the negative area is going to be a darker green color.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000052.mp3" }
EN_B00000_S05963_W000052.mp3
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EN_B00000_S05963_W000053
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3022, "duration": 18.149, "id": "EN_B00000_S05963_W000053", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, so notice that it's a very thick layer corresponding with, uh, keratinocytes. Uhm, and that was, that is what yields this net-like pattern. And I'm gonna show you, when we go on to Bullis pemphigoid, it's a very different pattern, then I'll show you a picture of the two, uh, together so you'll be able to appreciate the difference.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000053.mp3" }
EN_B00000_S05963_W000053.mp3
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EN_B00000_S05963_W000054
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3013, "duration": 6.044, "id": "EN_B00000_S05963_W000054", "language": "en", "speaker": "EN_B00000_S05963", "text": " Again here, you can appreciate that fish net-like pattern and a very broad, uh, band.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000054.mp3" }
EN_B00000_S05963_W000054.mp3
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EN_B00000_S05963_W000055
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1093, "duration": 19.746, "id": "EN_B00000_S05963_W000055", "language": "en", "speaker": "EN_B00000_S05963", "text": " The diagnosis is by biopsy, which you can look just with H and E stain as we saw, or you can do immunofluorescence, or you can do both, it's usually done with both. Remember you're looking for IgG and C3, that's important that you know that this is IgG mediated, and remember that's a type 2 hypersensitivity reaction, they may ask you that too.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000055.mp3" }
EN_B00000_S05963_W000055.mp3
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EN_B00000_S05963_W000056
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.167, "duration": 12.547, "id": "EN_B00000_S05963_W000056", "language": "en", "speaker": "EN_B00000_S05963", "text": " The differential diagnosis is Bullis-Pemphigoid. Bullis-Pemphigoid, as we're gonna see, is Nikolsky negative. The blisters are often stronger, so you're more likely to see more blisters and fewer erosions, relatively speaking, on presentation.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000056.mp3" }
EN_B00000_S05963_W000056.mp3
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EN_B00000_S05963_W000057
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4093, "duration": 15.179, "id": "EN_B00000_S05963_W000057", "language": "en", "speaker": "EN_B00000_S05963", "text": " With bolus pemphigoid, they tend to be pruritic, whereas with pemphigus vulgaris, they tend to be really painful. Uh, with bolus pemphigoid, you're less likely to see ulcers on the mucous membranes. If you do, you're only gonna see it in the mouth, you're not gonna see it in the esophagus or anything, uh, anywhere like that.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000057.mp3" }
EN_B00000_S05963_W000057.mp3
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EN_B00000_S05963_W000058
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2201, "duration": 6.91, "id": "EN_B00000_S05963_W000058", "language": "en", "speaker": "EN_B00000_S05963", "text": " Microscopic evaluation for bolus pemphigoid is going to show separation from the, uh, between the epidermis and the dermis of that basement membrane.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000058.mp3" }
EN_B00000_S05963_W000058.mp3
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EN_B00000_S05963_W000059
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2925, "duration": 18.663, "id": "EN_B00000_S05963_W000059", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, usually presents on the palms and soles, whereas Pemphigus vulgaris spares the palms and soles. There will also be some connection to either a recent infection, namely herpes simplex or mycoplasma pneumonia, or the commencement of medication, and they'll either, uh, give you probably one of these three, either phenytoin, sulfas, or allopurinol.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000059.mp3" }
EN_B00000_S05963_W000059.mp3
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EN_B00000_S05963_W000060
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2176, "duration": 9.084, "id": "EN_B00000_S05963_W000060", "language": "en", "speaker": "EN_B00000_S05963", "text": " Atheistomatitis is just a canker sore. These are confined to the oral region. They're painful, but they're self-limited, so they're very isolated, uh, lesions.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000060.mp3" }
EN_B00000_S05963_W000060.mp3
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EN_B00000_S05963_W000061
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3053, "duration": 5.246, "id": "EN_B00000_S05963_W000061", "language": "en", "speaker": "EN_B00000_S05963", "text": " The treatment for Pemphigus vulgaris is cardicosteroids, typically oral prednisone.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000061.mp3" }
EN_B00000_S05963_W000061.mp3
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EN_B00000_S05963_W000062
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4538, "duration": 14.684, "id": "EN_B00000_S05963_W000062", "language": "en", "speaker": "EN_B00000_S05963", "text": " If the patient needs to be on it long term, we try to put them then on immunomodulators because you don't want to have somebody on corticosteroids long term because of the side effects, weight gain, osteoporosis, stuff like that.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000062.mp3" }
EN_B00000_S05963_W000062.mp3
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EN_B00000_S05963_W000063
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4207, "duration": 8.705, "id": "EN_B00000_S05963_W000063", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, so immunomodulators would be things like mycophenolate. However, I've read that rituximab can be used as well. Topical lidocaine can be given for pain.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000063.mp3" }
EN_B00000_S05963_W000063.mp3
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EN_B00000_S05963_W000064
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2803, "duration": 8.412, "id": "EN_B00000_S05963_W000064", "language": "en", "speaker": "EN_B00000_S05963", "text": " Okay, bullis pemphigoid is a chronic acquired autoimmune blistering disease. So very similar in that respect to pemphigus vulgaris.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000064.mp3" }
EN_B00000_S05963_W000064.mp3
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EN_B00000_S05963_W000065
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2112, "duration": 14.588, "id": "EN_B00000_S05963_W000065", "language": "en", "speaker": "EN_B00000_S05963", "text": " It's also characterized by IgG autoantibodies. However, these autoantibodies target the hemidesmosomes. Remember, the hemidesmosomes are what attach the stratum basale cells to the basement membrane.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000065.mp3" }
EN_B00000_S05963_W000065.mp3
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EN_B00000_S05963_W000066
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3556, "duration": 17.852, "id": "EN_B00000_S05963_W000066", "language": "en", "speaker": "EN_B00000_S05963", "text": " And so this results in the formation of a sub-epidermal blister. The epidermis will be intact. You won't have acathocytes. But what you will have is a separation at the basement membrane. And the result of this is what's known as pemphigoid, which is a separation of the epidermis from the dermis at the basement membrane.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000066.mp3" }
EN_B00000_S05963_W000066.mp3
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EN_B00000_S05963_W000067
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2011, "duration": 12.348, "id": "EN_B00000_S05963_W000067", "language": "en", "speaker": "EN_B00000_S05963", "text": " And it usually happens when it does happen in older people, 70s and 80s. The clinical presentation is tense fluid-filled pruritic blisters, and I probably should have bold-faced tense. These are tense, strong blisters.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000067.mp3" }
EN_B00000_S05963_W000067.mp3
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EN_B00000_S05963_W000068
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0485, "duration": 7.757, "id": "EN_B00000_S05963_W000068", "language": "en", "speaker": "EN_B00000_S05963", "text": " Usually they're just on the skin, not on the mucous membrane, but in about 10-30% of cases they are, uh, on the mucous membranes as well.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000068.mp3" }
EN_B00000_S05963_W000068.mp3
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EN_B00000_S05963_W000069
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4182, "duration": 13.26, "id": "EN_B00000_S05963_W000069", "language": "en", "speaker": "EN_B00000_S05963", "text": " And that's again probably mediated by the initial inflammatory infiltrate that happens prior to the actual separation of the layers. These are Nikolsky negative. You can't grow these.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000069.mp3" }
EN_B00000_S05963_W000069.mp3
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EN_B00000_S05963_W000070
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1693, "duration": 7.657, "id": "EN_B00000_S05963_W000070", "language": "en", "speaker": "EN_B00000_S05963", "text": " And the blisters may be filled with serous fluid or later blood and that's why when you look at these blisters some of them look yellow and some of them look red.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000070.mp3" }
EN_B00000_S05963_W000070.mp3
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EN_B00000_S05963_W000071
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2986, "duration": 18.031, "id": "EN_B00000_S05963_W000071", "language": "en", "speaker": "EN_B00000_S05963", "text": " The gross appearance are tense fluid filled blisters on the skin. They may vary in color depending on the contents of the blister and erosions will be present in places where the blisters have worn off. They may be generalized or they could be limited to one area like a single limb and that's in contrast to, uh, Pemphigus vulgaris.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000071.mp3" }
EN_B00000_S05963_W000071.mp3
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EN_B00000_S05963_W000072
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3275, "duration": 6.147, "id": "EN_B00000_S05963_W000072", "language": "en", "speaker": "EN_B00000_S05963", "text": " So you notice here, cirrus filled blisters, as well as some areas of erosion where blisters once were.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000072.mp3" }
EN_B00000_S05963_W000072.mp3
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EN_B00000_S05963_W000073
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3734, "duration": 13.361, "id": "EN_B00000_S05963_W000073", "language": "en", "speaker": "EN_B00000_S05963", "text": " Here you see some blisters in the later stages. They tend to start out with serous fluid and then they start to fill up with blood and then they erode. So you can see here some blood blisters as well as some serous filled blisters.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000073.mp3" }
EN_B00000_S05963_W000073.mp3
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EN_B00000_S05963_W000074
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0789, "duration": 8.048, "id": "EN_B00000_S05963_W000074", "language": "en", "speaker": "EN_B00000_S05963", "text": " The big difference is that you'll have separation of the epidermis from the underlying dermis at the base membrane. The dermis may also be edematous", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000074.mp3" }
EN_B00000_S05963_W000074.mp3
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EN_B00000_S05963_W000075
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1912, "duration": 4.839, "id": "EN_B00000_S05963_W000075", "language": "en", "speaker": "EN_B00000_S05963", "text": " And the blister cavity in dermis can also be infiltrated here with ESNFLs.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000075.mp3" }
EN_B00000_S05963_W000075.mp3
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EN_B00000_S05963_W000076
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1591, "duration": 5.212, "id": "EN_B00000_S05963_W000076", "language": "en", "speaker": "EN_B00000_S05963", "text": " With direct immunofluorescence, it will also reveal IgG and C3 deposits.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000076.mp3" }
EN_B00000_S05963_W000076.mp3
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EN_B00000_S05963_W000077
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4417, "duration": 15.083, "id": "EN_B00000_S05963_W000077", "language": "en", "speaker": "EN_B00000_S05963", "text": " However, in this case, you'll have a very narrow linear pattern at the epidermal aspect of the basement membrane. So you won't have fishnetting, you'll just have a little line going across and you'll see, you'll see the entire epidermis is completely intact.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000077.mp3" }
EN_B00000_S05963_W000077.mp3
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EN_B00000_S05963_W000078
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4026, "duration": 15.068, "id": "EN_B00000_S05963_W000078", "language": "en", "speaker": "EN_B00000_S05963", "text": " Here you can see eosinophils. This is, you're just looking at dermis here. Uh, you see some, uh, some edema with some space in between, uh, the, the fibers. Uhm, notice also, uh, where was it? Down here, uh,", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000078.mp3" }
EN_B00000_S05963_W000078.mp3
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EN_B00000_S05963_W000079
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3258, "duration": 8.671, "id": "EN_B00000_S05963_W000079", "language": "en", "speaker": "EN_B00000_S05963", "text": " Around the arterioles, you're gonna see, uh, some periarticular, uh, inflammatory exudate. Uh, but notice you see eosinophils.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000079.mp3" }
EN_B00000_S05963_W000079.mp3
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EN_B00000_S05963_W000080
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2634, "duration": 20.577, "id": "EN_B00000_S05963_W000080", "language": "en", "speaker": "EN_B00000_S05963", "text": " So right here, this is a good example, you see some periartil or infiltrate. Uhm, you see infiltration elsewhere in the dermis but you notice again the separation is at the level of the basement membrane. Notice here are your stratum basale cells and everything above that is completely intact.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000080.mp3" }
EN_B00000_S05963_W000080.mp3
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EN_B00000_S05963_W000081
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1988, "duration": 7.776, "id": "EN_B00000_S05963_W000081", "language": "en", "speaker": "EN_B00000_S05963", "text": " Again here you can see some eosinophils, uh, infiltrating, uh, in, in this case into the, uh, the blister cavity.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000081.mp3" }
EN_B00000_S05963_W000081.mp3
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EN_B00000_S05963_W000082
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2057, "duration": 6.775, "id": "EN_B00000_S05963_W000082", "language": "en", "speaker": "EN_B00000_S05963", "text": " Here's immunofluorescence. So notice how it's different here. You just see a very thin line. The epidermis is intact.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000082.mp3" }
EN_B00000_S05963_W000082.mp3
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EN_B00000_S05963_W000083
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.233, "duration": 13.617, "id": "EN_B00000_S05963_W000083", "language": "en", "speaker": "EN_B00000_S05963", "text": " You don't see any of that fishnetting. So here's Pemphigus vulgaris. You see fishnetting here because the, the antibodies are in and around the keratinocytes. Uh, whereas here, you only see it at the basement membrane.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000083.mp3" }
EN_B00000_S05963_W000083.mp3
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EN_B00000_S05963_W000084
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0677, "duration": 13.148, "id": "EN_B00000_S05963_W000084", "language": "en", "speaker": "EN_B00000_S05963", "text": " The diagnosis for Bull's Pemphigoid is the exact same way we go about diagnosing Pemphigus vulgaris and that's a biopsy of a fresh lesion. It's not going to help you if you do a biopsy of an erosion. You need to do it at a blister.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000084.mp3" }
EN_B00000_S05963_W000084.mp3
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EN_B00000_S05963_W000085
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2552, "duration": 14.268, "id": "EN_B00000_S05963_W000085", "language": "en", "speaker": "EN_B00000_S05963", "text": " And the treatment is pretty much the same as pemphigus vulgaris as well. The mainstay of treatment is corticosteroids, immunomodulators can be used for steroid sparing, and antihistamines can be used for the itching that often occurs with bolus pemphigoides.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000085.mp3" }
EN_B00000_S05963_W000085.mp3
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EN_B00000_S05963_W000086
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2859, "duration": 16.893, "id": "EN_B00000_S05963_W000086", "language": "en", "speaker": "EN_B00000_S05963", "text": " Traumatic blisters, we're not going to spend too much time on. They're pretty fairly easy to diagnose. Uhm, these are just isolated blisters that may occur from a variety of forces, usually from shearing forces. Uh, they can also be due to exposure to chemical like poison ivy and nickel, or they can be due to burns.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000086.mp3" }
EN_B00000_S05963_W000086.mp3
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EN_B00000_S05963_W000087
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4354, "duration": 13.769, "id": "EN_B00000_S05963_W000087", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, differentiating traumatic blisters from blistering disorders is based on clinical history. Uh, pretty easy. I mean, they're in isolation, or a patient may say, I was walking in the woods, or I was trying to open a container. Uh, I was trying to...", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000087.mp3" }
EN_B00000_S05963_W000087.mp3
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EN_B00000_S05963_W000088
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.4584, "duration": 11.1, "id": "EN_B00000_S05963_W000088", "language": "en", "speaker": "EN_B00000_S05963", "text": " I was trying to climb up Machu Picchu, the mountain where Machu Picchu is and I was using a walking stick and I blistered my finger.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000088.mp3" }
EN_B00000_S05963_W000088.mp3
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EN_B00000_S05963_W000089
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3258, "duration": 11.978, "id": "EN_B00000_S05963_W000089", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uh, from, uh, well, more of a hiking stick, I guess. Uh, but I was holding onto it so tightly that I blistered my finger. I have pretty nasty blood blister. So these can happen pretty easily. They can be serous or blood filled.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000089.mp3" }
EN_B00000_S05963_W000089.mp3
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EN_B00000_S05963_W000090
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1513, "duration": 14.204, "id": "EN_B00000_S05963_W000090", "language": "en", "speaker": "EN_B00000_S05963", "text": " And it's a clinical diagnosis. We don't really need to do anything for this. You don't need to use steroids or anything. Just symptomatic management. Keep the area clean to prevent infection. If you, if there is pain, and a lot of times there are. My blister kept me up at night. It was so bad.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000090.mp3" }
EN_B00000_S05963_W000090.mp3
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EN_B00000_S05963_W000091
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2836, "duration": 12.429, "id": "EN_B00000_S05963_W000091", "language": "en", "speaker": "EN_B00000_S05963", "text": " Uhm, just NSAIDs, uh, anti-inflammatories, that's all you need to do. But really keep the area clean to prevent infection because that's one of the complications that can come from blisters, especially once they erode is you can get a secondary infection.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000091.mp3" }
EN_B00000_S05963_W000091.mp3
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EN_B00000_S05963_W000092
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0892, "duration": 14.204, "id": "EN_B00000_S05963_W000092", "language": "en", "speaker": "EN_B00000_S05963", "text": " So just to recap, Pemphigus vulgaris and bolus pemphigoid are both blistering disorders that result from IgG-mediated infiltration targeting cell adhesion molecules. With Pemphigus vulgaris, it targets desmosomes. With bolus pemphigoid, it targets hemidesmosomes.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000092.mp3" }
EN_B00000_S05963_W000092.mp3
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EN_B00000_S05963_W000093
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2499, "duration": 8.476, "id": "EN_B00000_S05963_W000093", "language": "en", "speaker": "EN_B00000_S05963", "text": " Nikolsky sign is a useful clinical differentiator between the two disorders. Pemphigus vulgaris is Nikolsky positive. Volus pemphigoides is Nikolsky negative.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000093.mp3" }
EN_B00000_S05963_W000093.mp3
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EN_B00000_S05963_W000094
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0179, "duration": 7.228, "id": "EN_B00000_S05963_W000094", "language": "en", "speaker": "EN_B00000_S05963", "text": " The diagnosis is made by a biopsy of the lesion as well as immunofluorescence, which is looking for IgG and C3. Please remember that.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000094.mp3" }
EN_B00000_S05963_W000094.mp3
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EN_B00000_S05963_W000095
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3454, "duration": 16.86, "id": "EN_B00000_S05963_W000095", "language": "en", "speaker": "EN_B00000_S05963", "text": " Pemphigus vulgaris will show acantholysis within the epidermis, tomb stoning, and broad fishnetting on immunofluorescence, whereas bulls pemphigoid will show separation at the basement membrane, dermal infiltration, and edema, as well as narrow linear staining on immunofluorescence.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000095.mp3" }
EN_B00000_S05963_W000095.mp3
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EN_B00000_S05963_W000096
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3546, "duration": 11.836, "id": "EN_B00000_S05963_W000096", "language": "en", "speaker": "EN_B00000_S05963", "text": " And the treatment is first with corticosteroids. Immunomodulators can be used for steroid sparing and then symptomatic treatment as needed. And that's all I've got for you. If you have any questions, please write me a note below. Otherwise, I will see you next time.", "wav": "EN_B00000/EN_B00000_S05963/mp3/EN_B00000_S05963_W000096.mp3" }
EN_B00000_S05963_W000096.mp3
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EN_B00000_S05973_W000000
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0995, "duration": 6.808, "id": "EN_B00000_S05973_W000000", "language": "en", "speaker": "EN_B00000_S05973", "text": " How many episodes until 500? 14 days bruh. Well done. Well, we're having our 500th on a Tuesday in two weeks time.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000000.mp3" }
EN_B00000_S05973_W000000.mp3
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EN_B00000_S05973_W000001
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0942, "duration": 16.554, "id": "EN_B00000_S05973_W000001", "language": "en", "speaker": "EN_B00000_S05973", "text": " Oh, the worst was when I was a young gronk and I've been on the receiving end of this too and done the non-gronk move of giving the money back. But when you say, say you're paying for something and you, you hand over coins and notes and you say, I'll just have the 10 back.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000001.mp3" }
EN_B00000_S05973_W000001.mp3
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EN_B00000_S05973_W000002
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1294, "duration": 14.55, "id": "EN_B00000_S05973_W000002", "language": "en", "speaker": "EN_B00000_S05973", "text": " What I mean, what you have to empathize with is the person who thinks it's good to go after that as a case. Like the person that actually thinks I broke my foot, connected to the water thing. I was walking and I hurt myself.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000002.mp3" }
EN_B00000_S05973_W000002.mp3
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EN_B00000_S05973_W000003
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.162, "duration": 5.28, "id": "EN_B00000_S05973_W000003", "language": "en", "speaker": "EN_B00000_S05973", "text": " If they don't rock out with your food, that's pretty fucking annoying. The grounds for anger.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000003.mp3" }
EN_B00000_S05973_W000003.mp3
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EN_B00000_S05973_W000004
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.081, "duration": 9.542, "id": "EN_B00000_S05973_W000004", "language": "en", "speaker": "EN_B00000_S05973", "text": " We had a situation here, it was a late night Friday, ordered pizzas, the guy came and I looked, he had a backpack.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000004.mp3" }
EN_B00000_S05973_W000004.mp3
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EN_B00000_S05973_W000005
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.3795, "duration": 12.892, "id": "EN_B00000_S05973_W000005", "language": "en", "speaker": "EN_B00000_S05973", "text": " Which does not fit a pizza in it unless it's on its side and he takes it out and he looks so frazzled, frazzled, frazzled, frazzled. If only he was frazzled.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000005.mp3" }
EN_B00000_S05973_W000005.mp3
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EN_B00000_S05973_W000006
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.0189, "duration": 4.448, "id": "EN_B00000_S05973_W000006", "language": "en", "speaker": "EN_B00000_S05973", "text": " And I just said, don't worry about it, man. It's all good. Like I was like, this poor bastard.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000006.mp3" }
EN_B00000_S05973_W000006.mp3
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EN_B00000_S05973_W000007
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2852, "duration": 18.252, "id": "EN_B00000_S05973_W000007", "language": "en", "speaker": "EN_B00000_S05973", "text": " The definition of a Gronk, and we just used real life examples, is someone who complains or tries to get a refund on food where they know in their heart of hearts they wouldn't do it if they were at a restaurant or they're just taking the piss. I've never done it at a restaurant in my life, but Uber Eats.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000007.mp3" }
EN_B00000_S05973_W000007.mp3
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EN_B00000_S05973_W000008
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.1483, "duration": 12.665, "id": "EN_B00000_S05973_W000008", "language": "en", "speaker": "EN_B00000_S05973", "text": " It's a massive cronk move. If you're taking advantage of this platform, like you're going, ah, they're big, they don't worry. It's not, not an issue for them. Like that's a massive cronk move. Like if it's,", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000008.mp3" }
EN_B00000_S05973_W000008.mp3
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EN_B00000_S05973_W000009
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.2822, "duration": 11.697, "id": "EN_B00000_S05973_W000009", "language": "en", "speaker": "EN_B00000_S05973", "text": " I mean, you get cold food all the time. You ex- like think about what you're, you're expecting. You're expecting a super hot pizza that's been delivered on a bike. Like that fucking isn't the reality.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000009.mp3" }
EN_B00000_S05973_W000009.mp3
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EN_B00000_S05973_W000010
hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar
{ "dnsmos": 3.13, "duration": 11.341, "id": "EN_B00000_S05973_W000010", "language": "en", "speaker": "EN_B00000_S05973", "text": " You get it hot from the restaurant. It could get cold when you take it home. And so if you then complain about a cold pizza, because the delivery guys brought it to you, the difference is if it's turned into a calzone.", "wav": "EN_B00000/EN_B00000_S05973/mp3/EN_B00000_S05973_W000010.mp3" }
EN_B00000_S05973_W000010.mp3
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