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EN_B00000_S07903_W000047 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Are better at defending against game than others, but we're not really sure. I mean, and there could be, you could conceive of many different reasons.",
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EN_B00000_S07903_W000048 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Why in theory that could be the case, but I will say that if you look at the genetics, they've already learned a lot about what the genes are that determine why some people are susceptible and some people are not. And we have a lot to learn about it, but it mostly revolves around the brain.",
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EN_B00000_S07903_W000049 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000050 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " So, the conceptual division we're making here, homeostatic regulation is all about the brain trying to manage your body's energy status.",
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EN_B00000_S07903_W000051 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " So your brain feels hungry because it perceives that you need energy.",
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EN_B00000_S07903_W000052 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Whereas non-homeostatic is everything else. It's stuff that's not related to energy.",
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EN_B00000_S07903_W000053 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Maybe the food is just right in front of you. Maybe it's time to eat because it's noon. Maybe you're drinking a beer because you want the enjoyment of it. Or maybe you're doing it because it's a dopamine-fueled motivational state.",
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EN_B00000_S07903_W000054 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And so I think that's the one that you're most interested in. So I'll focus on that. Yeah. So, I mean, we have this incredible system in our brains.",
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EN_B00000_S07903_W000055 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000056 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And, and of course there's many other parts of the brain that are kind of involved in this process, but that's really the part of the brain that is regulating our motivation and especially our kind of visceral motivational drive that we might associate with the word craving, for example, or addiction.",
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EN_B00000_S07903_W000057 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " So every single addictive drug there is impacts this dopamine circuit in the brain. So that's like almost by definition, if something is addictive, it is impacting this dopamine circuit in the brain.",
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EN_B00000_S07903_W000058 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"duration": 18.684,
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"text": " And so as it turns out, this dopamine circuit in the brain didn't evolve to make us want drugs. It evolved to make us want natural rewards, things that our ancestors experienced like food and sex and probably a bunch of other desirable outcomes as well.",
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EN_B00000_S07903_W000059 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Would have contributed to the survival and reproduction of our ancestors. So it's kind of like this basic goal setting and motivational system to drive you on a very visceral motivational level toward things that would have benefited your distant ancestors.",
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EN_B00000_S07903_W000060 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And it's probably more complicated than this, but this is the basic outline. We have receptors in our digestive tract, particularly the small intestine. Those detect the chemical composition of the food that you eat. So they figure out what's in that food. They have specific receptors for specific types of things that your brain cares about.",
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EN_B00000_S07903_W000061 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Those cells lining your small intestine are directly hooked up to neurons that go up your vagus nerve and straight to your brainstem.",
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EN_B00000_S07903_W000062 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " And once they're there, they disseminate that signal to the rest of your brain and that signal is used for things like feelings of satiety. But another thing that's used for is to secrete dopamine.",
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EN_B00000_S07903_W000063 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Probably salt, although the evidence is not as strong there. Probably glutamate, which is that umami flavor. Again, the evidence is not as strong there. But especially those calorie containing macronutrients, carbohydrate, fat, and protein. Protein is a little special, so I tend to focus on carbohydrate and fat.",
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EN_B00000_S07903_W000064 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And so you eat these things and essentially you get dopamine release in proportion to their concentrations. So when you eat a food that is highly concentrated, particularly when it starts to combine carbohydrate and fat together.",
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EN_B00000_S07903_W000065 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, exactly. You start to get higher levels of dopamine release in the brain. Higher levels of dopamine release cause a heightened motivational state. That's what dopamine does. It causes you to, particularly to learn",
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EN_B00000_S07903_W000066 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And I think I will say that within the research community, it's controversial to refer to food as addictive. I'm not saying that's wrong. I'm just saying there's ongoing controversy about whether they want to use that term or not. I just wanted to acknowledge that briefly.",
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EN_B00000_S07903_W000067 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000068 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Not necessarily the pleasure of that food, it is the motivational state",
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EN_B00000_S07903_W000069 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And ultimately that's the thing that matters the most in that situation. And it's the same with drugs of abuse. Like if you are someone who, you know, let's say you really, really like cigarettes, but you're not motivated to consume them.",
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EN_B00000_S07903_W000070 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000071 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, I agree with that. And the dopamine, yeah, it's the motivational state and it causes learning in the brain that sets your future motivational state and your response to cues that predict the acquisition of that reward, whether it's a food or a drug or whatever it is.",
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EN_B00000_S07903_W000072 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, I think so. I mean, I think that it's an opposing force. So like, you know, there's a certain point at which you may feel so full that it doesn't matter how much you want to eat something, you're sick. But yes, like it can cause people to eat more than they would normally eat.",
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EN_B00000_S07903_W000073 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000074 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000075 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And so like your body didn't need that energy, you were already full. But as soon as it comes in the right form, that the brain really highly values on that non homeostatic level, on that reward level,",
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EN_B00000_S07903_W000076 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Then suddenly you're prepared to consume those, those additional calories. So yeah, I think that's right. The non homeostatic, there's kind of an interplay between the homeostatic and the non homeostatic and the non homeostatic can kind of push you beyond the bounds that the homeostatic systems would normally set.",
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EN_B00000_S07903_W000077 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Huh. This is interesting. I'm actually not familiar with this. I would love to hear more about this volume addiction. I'm not familiar with this.",
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EN_B00000_S07903_W000078 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " So uhm, let me ask a follow up question here. So is this, would you say this is independent of hunger? So it's not like they're still hungry.",
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EN_B00000_S07903_W000079 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, that's interesting. This is not something I'm familiar with, so I'm afraid I'm not going to be able to provide any deep insights. I will speculate a little bit in case it's interesting. The only thing I'll mention here is that",
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EN_B00000_S07903_W000080 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " So these receptors in the gut that communicate information to the brain, they're involved, that signal ultimately is conveying satiety information as well as reward information.",
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EN_B00000_S07903_W000081 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " So I mean the stomach stretch receptors are known to be important in satiety. So I wonder if it could be a similar situation where actually maybe that's part of the reward signal too, just like the nutrient sensing.",
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EN_B00000_S07903_W000082 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, it's a good question. I mean, probably. I don't know, but I would say if I had to guess, I would say yes, that genetic differences are going to explain at least in part why some people respond to certain types of diets over others.",
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EN_B00000_S07903_W000083 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Well, for one, they eliminate a lot of commonly eaten, highly processed foods typically, which are the most common triggers for cravings and addiction-like behaviors.",
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EN_B00000_S07903_W000084 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " Which also that fat carbohydrate combination is also a major trigger of cravings and addiction like eating behavior. And so I think in those ways they do have some commonality.",
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EN_B00000_S07903_W000085 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " So I think that that is one factor. I think there are multiple factors that lead us to overconsume calories and I think some of them are, are actually homeostatic.",
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EN_B00000_S07903_W000086 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " So in my book, you know, in my book I have different chapters that are on different facets of, of why I think this occurs. But one thing that I think is important to understand on the homeostatic side is that obesity is a self-sustaining state.",
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EN_B00000_S07903_W000087 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " So once your set point, once a person develops obesity and their set point is elevated, their brain at that point is kind of forcing them to continue consuming that higher level of calories, even though consciously they probably don't want to.",
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EN_B00000_S07903_W000088 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000089 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " But I think there are also a lot of other things that aren't homeostatic that push us to eat more calories and certainly that reward is, is one of them. And you know, one way of saying it is that the food is, is tasty, but",
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EN_B00000_S07903_W000090 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000091 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, so I want to start off by saying that that program is kind of in a transition point right now and I'm not sure where it's going to be like a year from now as a result of some changes that are going on within that organization.",
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EN_B00000_S07903_W000092 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000093 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000094 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Are first of all to limit the cues. So, you know, whatever your trigger foods are, be very careful about not exposing yourself to those foods. Don't make them, don't have them in your personal environment. Ideally don't have them in your house. Don't see them. Don't smell them to the extent that you're able.",
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EN_B00000_S07903_W000095 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000096 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " Second week it's easier, and then a year from then they might just be totally grossed out by cigarettes.",
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EN_B00000_S07903_W000097 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And so there's this kind of gradual extinction that happens of that motivational state, which can be very rapidly reignited if you reintroduce the reward. So smoke the cigarette or eat the food. So I think avoiding the particularly problematic foods in the long run and just letting that kind of settle out, I think is another helpful strategy.",
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EN_B00000_S07903_W000098 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And then in terms of the food you're eating, eating simple lower calorie density foods that are just not as triggering for those dopaminergic systems.",
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EN_B00000_S07903_W000099 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah. I mean, I think this really depends on what kind of person you are. So I think, you know, I did a highly scientific Twitter poll on this a little while ago. Of course I'm joking. It's not scientific, but I was just curious among my followers, like, are you an abstinence person or are you a moderation person? Like which one works for you? And it was basically 50 50, which kind of surprised me.",
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EN_B00000_S07903_W000100 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " I would think that people who are having more problems along the lines of strong cravings and food addiction and like the dopaminergic type of stuff.",
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EN_B00000_S07903_W000101 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " I would think that those people would fall more into the abstinence would be more effective category and then maybe people who, whose, you know, weight management challenges are not as much in that category might do better with",
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EN_B00000_S07903_W000102 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Are you thinking just like the average person with obesity or are you thinking someone specifically who's suffering from food addiction challenges?",
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EN_B00000_S07903_W000103 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Okay, first of all, I think that these, the issues we're talking about with strong cravings and addiction like eating behavior or food addiction or whatever you want to call that.",
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EN_B00000_S07903_W000104 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " I think to some degree this is something that affects everyone. I think some people have more of a problem with it and some people have less of a problem with it, but I think it's really a spectrum. It's not like there's this sharp cutoff that some people are addicted to food and other people are totally not at all.",
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EN_B00000_S07903_W000105 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " In my opinion, for the average person who has obesity, at least some element of that, of what we were talking about, about limiting cues and, you know, abstinence from particularly problem foods and not using the calorie dense, highly stimulating",
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EN_B00000_S07903_W000106 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"language": "en",
"speaker": "EN_B00000_S07903",
"text": " But then I think there are some other things that are really beneficial for general obesity and also people with obesity who may have food addiction challenges.",
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EN_B00000_S07903_W000107 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " And I think eating foods that have a higher satiety value per calorie. So in other words, they're more filling per unit calorie is something that's helpful. And basically I can get into greater detail if you'd like, but the basic principle is lower calorie density.",
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EN_B00000_S07903_W000108 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " More unrefined, higher protein foods. So you know, the more refined it is, the more processed it is, the more calorie dense, like rich, concentrated in carbs and fat, added sugars, added fats.",
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EN_B00000_S07903_W000109 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " The worse it is, the simpler it is, the more unrefined, the lower in calorie density like more along the lines of whole grains and",
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EN_B00000_S07903_W000110 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Leaner meats and things like that. Vegetables, fruit, whole fresh fruit.",
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EN_B00000_S07903_W000111 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " I think those are going to be the things that are more supportive to people. And clearly, those are the things that create a lot more fullness per unit calorie. In other words,",
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EN_B00000_S07903_W000112 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " You eat a meal of those foods, you can reach the point where you feel satisfied with fewer calories than if you were eating different types of foods. And you don't have to count your calories at all to do that. This is just a natural process that occurs.",
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EN_B00000_S07903_W000113 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " By the way, that's an example of what I'm talking about where I think calories are important, but I don't necessarily think we need to be focusing on calories in particular as the thing we're trying to change.",
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EN_B00000_S07903_W000114 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, so this is the big question and is also really the biggest challenge because if you look, I mean, you know, there are a lot of people who have been trying to do this for a long time. And if you look at diet trials, for example, what you see is that people with obesity will lose a certain amount of weight.",
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EN_B00000_S07903_W000115 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"language": "en",
"speaker": "EN_B00000_S07903",
"text": " They will start to regain and by one year on average, generally they have regained most of the weight they lost. And then if you follow them up for another few years, usually they've regained almost all of it. So there are more successful and less successful approaches.",
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EN_B00000_S07903_W000116 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " And I think certainly you get a lot more value if you have good guidance and strong and consistent support. So one example of that, I'll cite the Virta health study. Have you seen that one? This is a program that uses a ketogenic diet for type two diabetes as well as intensive support.",
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EN_B00000_S07903_W000117 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Okay, yeaah. And they've been able to maintain pretty good weight loss for two years now is the latest follow up that I've seen. And people are regaining, but they're still lower than where they started. So I think that intensive support is really important.",
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EN_B00000_S07903_W000118 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " But you know, I want to be really, really honest here that there is no diet and lifestyle strategy that we currently have that can reliably transform a person with obesity into a person who is lean.",
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EN_B00000_S07903_W000119 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"speaker": "EN_B00000_S07903",
"text": " But when you do scientific studies where you're taking a certain number of people and you're following average trajectories,",
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EN_B00000_S07903_W000120 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Between 4 and 7% of body weight, depending on what year you look at, and they saw a 58% reduction in the risk of developing type 2 diabetes.",
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EN_B00000_S07903_W000121 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And that's like, that's not biomarkers, that's actual people developing diabetes reduced by 58%. So you can actually see massive health gains even from modest weight loss. But to address what you're saying is,",
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EN_B00000_S07903_W000122 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Or is it partly that and partly that these systems kick in and they start fighting back these homeostatic systems and people just can't maintain the discipline anymore?",
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EN_B00000_S07903_W000123 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, I think so. And, but I mean, there's no doubt that the better you can adhere to an effective diet, the better the results you're going to get. Absolutely no doubt about that.",
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EN_B00000_S07903_W000124 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And the better the support you get, the better you're going to be able to adhere to that diet. I think those are two conclusions that are very well supported at this point.",
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EN_B00000_S07903_W000125 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000126 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000127 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000128 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Yeah, I think that the thing that has been really cool over the years has just been seeing how some of this stuff has really gotten fleshed out. So when I first wrote my book,",
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EN_B00000_S07903_W000129 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000130 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " I am not writing about it. I do share some papers on Twitter and I do mention it in my talks now. But yeah, I mean, when I wrote my book, it could have been a hormone. We didn't know how the signal got to the brain, but now we know that it is primarily a neural signal.",
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EN_B00000_S07903_W000131 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000132 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000133 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000134 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000135 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000136 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000137 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000138 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07903_W000139 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " And I just wish I had been aware of and involved in that space from uh, much earlier.",
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EN_B00000_S07903_W000140 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07913_W000000 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " Is Miller going to be close enough to strike on Marquez into Dunlop's chicane? You bet he is. Is it going to be the block pass, just part of that KTM now in the middle of that chicane? They'll all bunch up behind the Australian now, but Miller hits the front for the first time.",
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EN_B00000_S07913_W000001 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " I was going to say too tight. He was too tight, wasn't he? Because around the outside of him, there was clear contact there. How many times has Vinales had contacted early race? I don't know if he might have lost some aero there. Looked like something might have broken off his bike, but Vinales are trying to run that tight inside sweeping run.",
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EN_B00000_S07913_W000002 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07913_W000003 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " In the space of what, 30 seconds, Vignoles and Bagnoles have gone out of victory contention. Out of podium contention now go Marini and Alex Marquez. Both instances pretty scary. It looks like thankfully all four of them up on their feet and okay.",
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EN_B00000_S07913_W000004 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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EN_B00000_S07913_W000005 | hf://datasets/amphion/Emilia-Dataset@bcaad00d13e7c101485990a46e88f5884ffed3fc/EN/EN-B000003.tar | {
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"text": " There's nothing that you can say that was Marini's fault. Nothing Alex Marquez could do about that one. How on earth you've gone down the road there, because neither of them...",
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