TOM500 — Thyroid eye disease Orbital MRI 500

Public release of the TOM500 dataset: coronal T2-weighted DRIVE orbital MRI of 500 patients with clinically confirmed Thyroid Eye Disease (TED), with multi-organ segmentations of nine periocular structures and bundled clinical metadata.

Dataset Summary

Field	Details
Modality	T2-weighted DRIVE MRI (coronal, 3.0T Philips Ingenia, 32-ch head coil)
In-plane resolution	0.3125 mm
Slice thickness	3.5 mm
Volume shape	512 × 512 × 20
Body Part	Orbit (eye + periocular structures)
Subjects	500 patients with Thyroid Eye Disease
Splits	Train 400 / Val 100
Classes	0=background + 9 organ structures (10 classes total)
Annotation	3 junior radiologists per case → STAPLE consensus → senior expert review/correction
Total Size	~2.4 GB
License	CC0 1.0 (Figshare metadata)
Source	Figshare DOI: 10.6084/m9.figshare.27133389
Cohort	Shanghai Ninth People's Hospital, Jun 2016 – Jan 2021

Label scheme

Value	Structure
0	background
1	optic nerve
2	orbital fat
3	lacrimal gland
4	eyeball
5	superior rectus + levator palpebrae superioris complex
6	inferior rectus
7	medial rectus
8	lateral rectus
9	superior oblique

Data Structure

TOM500/
├── train/
│   ├── image/   400 × {patient_id}.nii.gz   # T2-DRIVE orbital MRI
│   └── label/   400 × {patient_id}.nii.gz   # multi-class STAPLE+expert mask
└── val/
    ├── image/   100 × {patient_id}.nii.gz
    └── label/   100 × {patient_id}.nii.gz

The original release also bundles a clinical metadata CSV (sex, age, disease duration, smoking status); see the source Figshare record if you need it.

Citation

@article{zhang2025tom500,
  title   = {TOM500: A Multi-Organ Annotated Orbital MRI Dataset for Thyroid Eye Disease},
  author  = {Zhang, Hongbo and others},
  journal = {Scientific Data},
  volume  = {12},
  pages   = {60},
  year    = {2025},
  doi     = {10.1038/s41597-025-04427-9}
}

@dataset{tom500_figshare_2024,
  title     = {TOM500: A Multi-Organ Annotated Orbital MRI Dataset for Thyroid Eye Disease},
  author    = {Zhang, Hongbo and others},
  year      = {2024},
  publisher = {Figshare},
  doi       = {10.6084/m9.figshare.27133389}
}