| { | |
| "train_drugs": [ | |
| "2-Methoxyestradiol", | |
| "A-366", | |
| "ABT-737", | |
| "AG-490", | |
| "AMG-900", | |
| "AR-42", | |
| "AT9283", | |
| "AZ", | |
| "AZD1480", | |
| "Abexinostat", | |
| "Alisertib", | |
| "Altretamine", | |
| "Alvespimycin", | |
| "Aminoglutethimide", | |
| "Anacardic", | |
| "Andarine", | |
| "Aurora", | |
| "Avagacestat", | |
| "BMS-265246", | |
| "BMS-536924", | |
| "BMS-911543", | |
| "BRD4770", | |
| "Barasertib", | |
| "Baricitinib", | |
| "Bisindolylmaleimide", | |
| "Bosutinib", | |
| "Busulfan", | |
| "CEP-33779", | |
| "CUDC-907", | |
| "CYC116", | |
| "Capecitabine", | |
| "Carmofur", | |
| "Cediranib", | |
| "Celecoxib", | |
| "Cerdulatinib", | |
| "Clevudine", | |
| "Costunolide", | |
| "Crizotinib", | |
| "Curcumin", | |
| "Cyclocytidine", | |
| "Dacinostat", | |
| "Danusertib", | |
| "Dasatinib", | |
| "Decitabine", | |
| "Disulfiram", | |
| "Divalproex", | |
| "Droxinostat", | |
| "EED226", | |
| "ENMD-2076", | |
| "Ellagic", | |
| "Entacapone", | |
| "Entinostat", | |
| "Enzastaurin", | |
| "Epothilone", | |
| "FLLL32", | |
| "Fasudil", | |
| "Fedratinib", | |
| "Filgotinib", | |
| "Flavopiridol", | |
| "Fluorouracil", | |
| "Fulvestrant", | |
| "G007-LK", | |
| "GSK", | |
| "GSK1070916", | |
| "Gandotinib", | |
| "Givinostat", | |
| "Glesatinib?(MGCD265)", | |
| "Hesperadin", | |
| "IOX2", | |
| "ITSA-1", | |
| "Iniparib", | |
| "Ivosidenib", | |
| "JQ1", | |
| "KW-2449", | |
| "Ki16425", | |
| "Ki8751", | |
| "Lapatinib", | |
| "Lenalidomide", | |
| "Linifanib", | |
| "Lomustine", | |
| "Luminespib", | |
| "M344", | |
| "MC1568", | |
| "MK-0752", | |
| "MK-5108", | |
| "Maraviroc", | |
| "Meprednisone", | |
| "Mercaptopurine", | |
| "Mesna", | |
| "Mocetinostat", | |
| "Motesanib", | |
| "Navitoclax", | |
| "Nilotinib", | |
| "Obatoclax", | |
| "Ofloxacin", | |
| "PCI-34051", | |
| "PD173074", | |
| "PD98059", | |
| "PF-3845", | |
| "PF-573228", | |
| "PFI-1", | |
| "PJ34", | |
| "Panobinostat", | |
| "Patupilone", | |
| "Pelitinib", | |
| "Pirarubicin", | |
| "Pracinostat", | |
| "Prednisone", | |
| "Quercetin", | |
| "Quisinostat", | |
| "RG108", | |
| "Ramelteon", | |
| "Regorafenib", | |
| "Resminostat", | |
| "Resveratrol", | |
| "Rigosertib", | |
| "Roscovitine", | |
| "Rucaparib", | |
| "Ruxolitinib", | |
| "S-Ruxolitinib", | |
| "S3I-201", | |
| "SGI-1776", | |
| "SL-327", | |
| "SNS-314", | |
| "SRT1720", | |
| "SRT2104", | |
| "SRT3025", | |
| "Selisistat", | |
| "Sirtinol", | |
| "Sorafenib", | |
| "Streptozotocin", | |
| "TAK-901", | |
| "TG101209", | |
| "TGX-221", | |
| "Tacedinaline", | |
| "Tanespimycin", | |
| "Tazemetostat", | |
| "Temsirolimus", | |
| "Thalidomide", | |
| "Thiotepa", | |
| "Tie2", | |
| "Tofacitinib", | |
| "Tozasertib", | |
| "Trametinib", | |
| "Tranylcypromine", | |
| "Triamcinolone", | |
| "Trichostatin", | |
| "Tubastatin", | |
| "Tucidinostat", | |
| "UNC0379", | |
| "UNC0631", | |
| "UNC1999", | |
| "Valproic", | |
| "Vandetanib", | |
| "Veliparib", | |
| "WHI-P154", | |
| "WP1066", | |
| "XAV-939", | |
| "YM155", | |
| "ZM", | |
| "Zileuton" | |
| ], | |
| "ood_drugs": [ | |
| "AC480", | |
| "AG-14361", | |
| "AICAR", | |
| "Alendronate", | |
| "Amisulpride", | |
| "Azacitidine", | |
| "BMS-754807", | |
| "Belinostat", | |
| "CUDC-101", | |
| "Cimetidine", | |
| "Daphnetin", | |
| "GSK-LSD1", | |
| "INO-1001", | |
| "JNJ-26854165", | |
| "JNJ-7706621", | |
| "MLN8054", | |
| "Momelotinib", | |
| "NVP-BSK805", | |
| "Nintedanib", | |
| "PHA-680632", | |
| "Raltitrexed", | |
| "Roxadustat", | |
| "SB431542", | |
| "TMP195", | |
| "Toremifene" | |
| ], | |
| "seed": 1, | |
| "n_train": 161, | |
| "n_ood": 25, | |
| "stratum_counts": { | |
| "PKC signaling": { | |
| "eligible": 3, | |
| "ood": 1 | |
| }, | |
| "Epigenetic regulation": { | |
| "eligible": 46, | |
| "ood": 5 | |
| }, | |
| "Cell cycle regulation": { | |
| "eligible": 21, | |
| "ood": 3 | |
| }, | |
| "Other": { | |
| "eligible": 6, | |
| "ood": 1 | |
| }, | |
| "Tyrosine kinase signaling": { | |
| "eligible": 29, | |
| "ood": 3 | |
| }, | |
| "JAK/STAT signaling": { | |
| "eligible": 22, | |
| "ood": 2 | |
| }, | |
| "Focal adhesion signaling": { | |
| "eligible": 2, | |
| "ood": 0 | |
| }, | |
| "Protein folding & Protein degradation": { | |
| "eligible": 7, | |
| "ood": 0 | |
| }, | |
| "HIF signaling": { | |
| "eligible": 3, | |
| "ood": 1 | |
| }, | |
| "DNA damage & DNA repair": { | |
| "eligible": 19, | |
| "ood": 3 | |
| }, | |
| "Apoptotic regulation": { | |
| "eligible": 5, | |
| "ood": 1 | |
| }, | |
| "Nuclear receptor signaling": { | |
| "eligible": 6, | |
| "ood": 1 | |
| }, | |
| "Antioxidant": { | |
| "eligible": 4, | |
| "ood": 1 | |
| }, | |
| "TGF/BMP signaling": { | |
| "eligible": 3, | |
| "ood": 1 | |
| }, | |
| "Neuronal signaling": { | |
| "eligible": 4, | |
| "ood": 1 | |
| }, | |
| "Metabolic regulation": { | |
| "eligible": 6, | |
| "ood": 1 | |
| } | |
| }, | |
| "swap_note": "v2b: swapped Belinostat (TRAIN->OOD) with SRT1720 (OOD->TRAIN). Both Epigenetic regulation stratum; iter169 plan named SRT2104 but that drug is in TRAIN under v2. Motivation: restore belinostat OOD to match the wet-lab narrative (MCF7 qPCR + microscopy)." | |
| } |