PMID int64 2.09k 36.2M | Title stringlengths 21 414 | Abstract stringlengths 175 8.83k | Split stringclasses 1
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33,596,356 | Avacopan for the Treatment of ANCA-Associated Vasculitis. | The C5a receptor inhibitor avacopan is being studied for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. In this randomized, controlled trial, we assigned patients with ANCA-associated vasculitis in a 1:1 ratio to receive oral avacopan at a dose of 30 mg twice daily or oral prednisone... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 876 |
17,681,160 | Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study. | Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use. A nested case-control study was conducted within 454 general practices in the United Kingdom using the QRESEARCH database. Cases with colorectal cancer were diagn... | Train | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | [
1,
0,
1,
1,
1,
1,
0,
1
] | 877 |
30,109,708 | Health benefits of an adverse events reporting system for chronic pain patients using long-term opioids. | Safety data from long-term opioid therapy in the real world has been poorly studied in chronic non-cancer pain (CNCP). The aim was to design a pharmacovigilance data recording system and assess whether participation in this recording system improves pain management, enhancing patient's health status. A pharmacovigilanc... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 878 |
15,673,346 | A 5-year prospective assessment of the risk associated with individual benzodiazepines and doses in new elderly users. | To determine the risk of injury associated with the new use of individual benzodiazepines and dosage regimens in the elderly. Prospective database cohort study with 5 years of follow-up. Quebec, Canada. Two hundred fifty-three thousand two hundred forty-four persons aged 65 and older who were nonusers of benzodiazepine... | Train | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
0,
1,
1,
1,
1,
0
] | 879 |
25,656,412 | Effect of pharmacological treatment for urinary incontinence in the elderly and frail elderly: A systematic review. | The prevalence and severity of urinary incontinence (UI) increase with age and comorbidity. The benefits of pharmacotherapy for UI in the elderly are questionable. The aim of the present study was to systematically review the efficacy of pharmacological treatment for UI in the elderly and frail elderly. We searched Pub... | Train | 3 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | [
1,
0,
1,
0,
1,
1,
1,
1
] | 880 |
30,270,066 | Treatment pattern of familial hypercholesterolemia in Slovakia: Targets, treatment and obstacles in common practice. | Maximal doses of potent statins are the cornerstone of treatment of familial hypercholesterolemia (FH). Despite this, a substantial proportion of FH patients are either under-treated or not treated at all. The aim of this work was to evaluate, in a retrospective study, the treatment of FH patients, the proportion of FH... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 881 |
23,598,842 | Utility of routine left ventricular ejection fraction measurement before anthracycline-based chemotherapy in patients with diffuse large B-cell lymphoma. | Despite the lack of evidence, routine left ventricular ejection fraction (LVEF) measurement in diffuse large B-cell lymphoma (DLBCL) before anthracycline-based chemotherapy (ABC) is recommended by practice guidelines and required in DLBCL trials in the United States. We determined the frequency of the following in 197 ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 882 |
34,921,960 | The ECHELON-2 Trial: 5-year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma. | For patients with peripheral T-cell lymphoma (PTCL), outcomes using frontline treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP-like therapy are typically poor. The ECHELON-2 study demonstrated that brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (A+CHP) exh... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 883 |
26,726,710 | Efficacy of Tolvaptan in Patients with Volume Overload after Cardiac Surgery. | The vasopressin type 2 receptor antagonist tolvaptan (TLV) has recently become available for treating congestion. However, there is no evidence confirming the efficacy of TLV for patients with volume overload after cardiac surgery. Here, we retrospectively studied the efficacy of TLV in patients with volume overload af... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 884 |
11,273,789 | Effect of the cyclooxygenase-2 inhibitor celecoxib on bronchial responsiveness and cough reflex sensitivity in asthmatics. | Cyclooxygenase (COX), an essential enzyme in the pathway of prostaglandin formation from arachidonic acid, exists in two isoforms. Cyclooxygenase-1 (COX-1) is expressed under normal physiologic conditions, whereas COX-2, the inducible isoform, is associated with inflammation. Recent studies have linked COX-2 induction ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 886 |
2,529,295 | Response of panic disorder to fixed doses of alprazolam or imipramine. | This paper reports the results of a double-blind comparison of fixed daily doses of 6 mg of alprazolam, 2 mg of alprazolam, 225 mg of imipramine, and placebo for 8 weeks in 81 patients who met DSM-III criteria for panic disorder with or without agoraphobia. Final scores on eight clinical measures were analyzed from all... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 887 |
24,655,690 | Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial. | P2Y12 receptor antagonist therapy is recommended in addition to ASA for up to 1 year after acute coronary syndrome to reduce ischemic events. In contrast, the benefit of long-term dual antiplatelet therapy beyond 1 year remains unclear. Ticagrelor is a potent, reversibly binding P2Y12 receptor-antagonist that has been ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 888 |
25,791,799 | [Prospective study of the new oral anticoagulants in private practice: cautious optimism]. | The new direct oral anticoagulants (DOA) such as dabigatran, rivaroxaban or apixaban are an evolution in the management of patients requiring curative anticoagulation. However, behind the simplicity of prescribing and monitoring, several questions remain about their daily use. The aim of this prospective study was to m... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
1,
0,
1,
1,
1,
0
] | 889 |
4,068,453 | [Change in the spectrum of lipids and apoproteins A1 and B as affected by hypothiazide and pratsiol in patients with hypertension]. | A comparative study of changes in plasma lipids, apo-A1 and apo-B under the effect of 2-week, 2-month and 6-month treatments with hydrochlorothiazide and pratsiol was conducted in 48 patients with arterial hypertension. Hydrochlorothiazide caused a significant increase in total cholesterol (CH), LDL cholesterol, apo-A1... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | [
1,
0,
1,
0,
0,
1,
1,
1
] | 890 |
7,622,801 | Mirtazapine is more effective than trazodone: a double-blind controlled study in hospitalized patients with major depression. | Two hundred hospitalized patients with DSM-III diagnosis of moderate to severe major depressive episode were randomized to receive mirtazapine or trazodone for 6 weeks in a double-blind trial. The dosages were 24-72 mg/day for mirtazapine and 150-450 mg/day for trazodone. The improvement on all depression rating scales... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 891 |
14,633,188 | Investigation on the efficacy of meloxicam in sows with mastitis-metritis-agalactia syndrome. | The efficacy of meloxicam in the treatment of sows with mastitis-metritis-agalactia syndrome was investigated in comparison with flunixin. Basic therapy comprised administration of an antibiotic and oxytocin. A total of 200 sows and litters were examined in a double-blind clinical study with observations up to 8 days a... | Train | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
0,
1,
1,
1,
1,
1,
1
] | 892 |
15,380,399 | Changes in anxiety sensitivity with pharmacotherapy for panic disorder. | Fear of anxiety symptoms (anxiety sensitivity) has been implicated in the etiology and maintenance of panic disorder, and has been shown to improve with cognitive-behavioral treatment. The impact of pharmacotherapy on anxiety sensitivity is less clear. We administered the Anxiety Sensitivity Index (ASI) during a 12-wee... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 893 |
32,830,338 | An understated danger: Antimicrobial resistance in aquaculture and pet fish in Switzerland, a retrospective study from 2000 to 2017. | Aquaculture is a rapidly growing field of food production. However, morbidity and mortality are higher in aquaculture species than in domestic animals. Bacterial diseases are a leading cause of farmed fish morbidity and are often treated with antimicrobials. Since most Swiss fish farms release effluents directly into s... | Train | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
0,
1,
1,
0,
1,
1,
0
] | 895 |
26,352,086 | Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder. | The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy con... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 896 |
27,626,622 | Sertraline for Preventing Mood Disorders Following Traumatic Brain Injury: A Randomized Clinical Trial. | Prevention is more effective than treatment to decrease the burden of significant medical conditions such as depressive disorders, a major cause of disability worldwide. Traumatic brain injury (TBI) is a candidate for selective strategies to prevent depression given the incidence, prevalence, and functional effect of d... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 897 |
9,411,327 | [AT1 angiotensin receptor inhibition as a new therapeutic possibility]. | The octapeptide hormone, angiotensin II, binds to two major subtypes of cell surface receptors: the AT1 and the AT2 angiotensin receptors. The important physiological and pathophysiological effects of angiotensin II on cardiovascular regulation and salt-water balance are mediated by the AT1 receptor subtype. As a conse... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | [
1,
0,
1,
0,
0,
1,
0,
0
] | 898 |
22,766,750 | Maternal exposure to amoxicillin and the risk of oral clefts. | Prior studies have suggested an increased risk of oral clefts after exposure to amoxicillin in early pregnancy, but findings have been inconsistent. Among participants in the Slone Epidemiology Center Birth Defects Study from 1994 to 2008, we identified 877 infants with cleft lip with/without cleft palate and 471 with ... | Train | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
0,
1,
1,
1,
1,
1
] | 901 |
10,343,145 | Resolution of gastritis induced by Helicobacter pylori 4-5 weeks after successful eradication of infection using a triple therapy regimen of pantoprazole, amoxycillin and clarithromycin for one week. | This open-label study was designed to determine the extent of histological resolution of gastritis induced by Helicobacter pylori infection 4-5 weeks after successful eradication of the infection. Eradication was achieved using a triple therapy regimen consisting of a twice daily dose of pantoprazole 40 mg, clarithromy... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 902 |
26,536,319 | Rosuvastatin Is Effective to Decrease CD8 T-Cell Activation Only in HIV-Infected Patients With High Residual T-Cell Activation Under Antiretroviral Therapy. | The aim of the trial was to evaluate in patients under antiretroviral therapy (ART) the effect of rosuvastatin on cellular and soluble markers of immune activation/inflammation, as well as to identify patients who better benefit from statin administration. IMEA-043-CESAR was a phase II open-label pilot trial that enrol... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 903 |
2,459,525 | Effects of amlodipine on steady-state digoxin concentrations and renal digoxin clearance. | The effect of oral amlodipine on steady-state digoxin concentrations and renal clearance was studied in 21 healthy male subjects. After 2-week digitalization (digoxin, 0.375 mg/day), they were randomized in a single-blind crossover protocol to receive either placebo or amlodipine (5 mg/day) in combination with digoxin ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 904 |
20,186,991 | Gender differences in the treatment of non-ST-segment elevation myocardial infarction. | Women are at greater risk for worse outcomes associated with acute coronary syndrome (ACS) than are men. One explanation may be that they tend to be treated less aggressively than men even when more aggressive treatment is warranted. The purpose of this analysis was to assess this issue. We used the Can Rapid Risk Stra... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 905 |
15,280,683 | Successful withdrawal of steroids in pediatric renal transplant recipients receiving cyclosporine A and mycophenolate mofetil treatment: results after four years. | Despite their numerous systemic side effects, glucocorticoids (steroids) still form a cornerstone in immunosuppressive regimens in pediatric renal transplant recipients. The addition of mycophenolate mofetil (MMF) to a cyclosporine A (CsA)-based immunosuppressive regimen after renal transplantation may allow steroid wi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 906 |
24,721,592 | Positron emission tomography/computed tomography findings during therapy predict outcome in patients with diffuse large B-cell lymphoma treated with chemotherapy alone but not in those who receive consolidation radiation. | To assess the value of mid-therapy positron emission tomography (PET) findings for predicting survival and disease progression in patients with diffuse large B-cell lymphoma, considering type of therapy (chemotherapy with or without radiation therapy). We retrospectively evaluated 294 patients with histologically confi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 907 |
17,462,208 | The effect of preoperative clopidogrel on bleeding after coronary artery bypass surgery. | Clopidogrel treatment is associated with a reduction in thrombotic complications in coronary stent placement, improved outcome after acute coronary syndromes, and decreased mortality in patients with coronary artery disease. The purpose of this study was to analyze the effect of preoperative clopidogrel exposure on ble... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 908 |
11,062,863 | The effect of zolpidem and zopiclone on memory. | The effect of 10 mg of zolpidem (ZLP) on memory function was evaluated in healthy male adults using word recall test, passage recall test, and Sternberg's memory scanning task. This study was carried out as a double-blind cross-over study with 7.5 mg of zopiclone (ZPC) and a placebo. No difference was noted between the... | Train | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | [
1,
1,
0,
1,
0,
1,
0,
1
] | 909 |
16,124,370 | [Usefulness of fenspiride in the treatment of acute otitis media in children]. | Acute otitis media is very general disease and concerns every child practically. The shortening the time of treatment as well as quick decrease of symptoms, and mainly the pain have large meaning in treatment of this disease. Combined treatment of fenspiride and typical treatment of otitis media permits as our investig... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 912 |
23,431,027 | Mucosal healing effect of mesalazine granules in naproxen-induced small bowel enteropathy. | To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE). This was a single center, non-randomized, open-label, uncontrolled pilot study, using the PillCam SB CE system with RAPID 5 software. The Lewis Index Score (LIS) for small bowel injury was inves... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 913 |
21,967,407 | Comparison of immunological parameters in patients with pemphigus vulgaris following rituximab and IVIG therapy. | Information on certain immunological parameters in patients with pemphigus vulgaris (PV) treated with rituximab (RTX) and intravenous immunoglobulin (IVIG) therapy is limited. Comparing immunological parameters in patients who achieved long-term clinical remission (LTR) with those who relapsed. Retrospective analysis o... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 915 |
34,507,829 | Statin therapy and its association with long-term survival after colon cancer surgery. | The current study aimed to address the clinical equipoise regarding the association of ongoing statin therapy at time of surgery with long-term postoperative mortality rates after elective, curative, surgical resections of colon cancer by analyzing data from a large validated national register. All adults with stage I ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 916 |
33,324,041 | Budesonide/Formoterol Anti-Inflammatory Reliever and Maintenance or Fluticasone Propionate/Salmeterol Plus As-Needed, Short-Acting β<sub>2</sub> Agonist: Real-World Effectiveness in pAtients without Optimally Controlled asThma (REACT) Study. | In the prospective, observational, 16-week REACT study conducted between October 21, 2008 and May 12, 2011, we compared the real-world effectiveness of anti-inflammatory reliever and maintenance therapy with budesonide/formoterol (Symbicort<sup>®</sup> Turbuhaler) and maintenance therapy with fixed-dose fluticasone/sal... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 917 |
11,430,633 | Pharmacoutilization of antihypertensive drugs: a model of analysis. | To identify clinical and economic indicators of pharmacoutilization of antihypertensive drugs. 4614 subjects receiving a first prescription for amlodipine, atenolol, fosinopril, indapamide, or losartan were included in the study. All prescriptions filled during the study period from January 1, 1997 to December 31, 1998... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 918 |
10,095,796 | Comparison of effects of quinapril and metoprolol on glycaemic control, serum lipids, blood pressure, albuminuria and quality of life in non-insulin-dependent diabetes mellitus patients with hypertension. Swedish Quinapril Group. | To compare the long-term effects of the angiotensin-converting enzyme (ACE)-inhibitor quinapril and the cardioselective beta-adrenergic blocking agent metoprolol on glycaemic control, with glycosylated haemoglobin (HbA1c) as the principal variable, in non-insulin-dependent diabetes mellitus (NIDDM) patients with hypert... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 919 |
1,106,278 | Cyclophosphamide or azathioprine in lupus glomerulonephritis. A controlled trial: results at 28 months. | Thirty-eight patients with diffuse glomerulonephritis of systemic lupus erythematosus were randomly assigned to add cyclophosphamide, azathioprine, or nothing to low-dose corticosteroid treatment and have been followed for a mean of 21/3 years thereafter. Of the 11 patients with unfavorable outcomes (8 deaths and 2 beg... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 920 |
28,774,310 | Small airway bronchodilator response to different doses of salbutamol in 7-year-old children. | The Global Initiative for Asthma (GINA) guidelines do not specify a bronchodilator range for bronchodilator response (BDR) testing and simply recommend a salbutamol dose of 200 to 400 μg. We determined the oscillometric BDR results of children given low-dose (2 puffs, 200 μg) and standard-dose (4 puffs, 400 μg) salbuta... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
1,
1,
1,
0,
1,
0,
0
] | 922 |
25,331,980 | A healthy lifestyle index is associated with reduced risk of colorectal adenomatous polyps among non-users of non-steroidal anti-inflammatory drugs. | In a Columbia, South Carolina-based case-control study, we developed a healthy lifestyle index from five modifiable lifestyle factors (smoking, alcohol intake, physical activity, diet, and body mass index), and examined the association between this lifestyle index and the risk of colorectal adenomatous polyps (adenoma)... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | [
1,
1,
1,
0,
1,
1,
1,
1
] | 923 |
2,305,760 | Quality-of-life issues for end-stage renal disease patients. | Given the importance of making comparisons regarding quality-of-life issues for end-stage renal disease (ESRD) patients, the research presented here first compares 766 patients who experienced one of the following therapies for at least 1 year: (1) center hemodialysis, (2) continuous ambulatory peritoneal dialysis (CAP... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | [
1,
1,
1,
0,
0,
1,
1,
1
] | 924 |
8,741,286 | [Survey and treatment strategy of antidepressant-resistant depression]. | The present study investigated the phenomenology and treatment of antidepressant-resistant depressions (ARD). To be classified a nonresponder, a patient had to have been treated adequately with two tricyclic (or tetracyclic) antidepressants (i.e., a minimum of the equivalent of 150 mg of imipramine for 4 weeks). The 34... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 925 |
28,445,145 | Influence of serum cholesterol level and statin treatment on prostate cancer aggressiveness. | Both cholesterol levels and the use of statins have been described to influence the development and prognosis of prostate cancer (PC). In this retrospective, cross-sectional analysis of consecutive cases from a tertiary referral center we evaluated an association between hypercholesterolemia (≥5.0mmol/l), the use of st... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 926 |
20,642,546 | Omeprazole preferentially inhibits the metabolism of (+)-(S)-citalopram in healthy volunteers. | Citalopram (CITA) pharmacokinetics are enantioselective in healthy volunteers and the metabolism of (+)-(S)-CITA to (+)-(S)-DCITA is dependent on CYP2C19. Omeprazole is a potent CYP2C19 inhibitor. This study indicates that omeprazole induces a loss of enantioselectivity in the CITA pharmacokinetics because of the selec... | Train | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
0,
1,
1,
1,
1,
0
] | 927 |
35,414,106 | Stop of proton-pump inhibitor treatment in patients with liver cirrhosis (STOPPIT): study protocol for a prospective, multicentre, controlled, randomized, double-blind trial. | Proton-pump inhibitors (PPI) are liberally prescribed in patients with liver cirrhosis. Observational studies link PPI therapy in cirrhotic patients with an increased risk for infectious complications, hepatic encephalopathy and an increased risk for hospitalization and mortality. However, patients with liver cirrhosis... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 929 |
22,298,240 | Clinical and epidemiological characteristics of adult patients hospitalized for erysipelas and cellulitis. | The purpose of this investigation was to analyze the clinical and epidemiological aspects of all cases of erysipelas and infectious cellulitis admitted to a tertiary hospital during a period of five years. All patients admitted with the main diagnosis of erysipelas or cellulitis to the Department of Dermatology of the ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | [
1,
1,
1,
1,
0,
0,
1,
0
] | 930 |
19,927,136 | Assessing medication adherence simultaneously by electronic monitoring and pill count in patients with mild-to-moderate hypertension. | Poor adherence to antihypertensive medication is one of the major problems in the treatment of hypertension. Electronic monitoring is currently considered to be the gold standard for assessing adherence, but it may trigger patients to open the pill bottle without taking medication or to take out more than prescribed. I... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 931 |
28,947,095 | High-dose corticosteroids improve the prognosis of Bell's palsy compared with low-dose corticosteroids: A propensity score analysis. | The aim of this study was to evaluate the effectiveness of high-dose corticosteroid (120mg prednisolone equivalent daily) in Bell's palsy compared with low-dose corticosteroid (60mg PSL equivalent). A single-center retrospective observational study was performed. We included adult Bell's palsy patients who were treated... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 932 |
10,751,862 | Prostate specific antigen response to mitoxantrone and prednisone in patients with refractory prostate cancer: prognostic factors and generalizability of a multicenter trial to clinical practice. | We determine prostate specific antigen (PSA) response and durability, and prognostic factors associated with response and survival in patients with symptomatic hormone refractory prostate cancer treated with mitoxantrone and prednisone at a single institution. We then compare the results with those of a randomized phas... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 933 |
14,675,576 | Effect of coadministration of ezetimibe and simvastatin on high-sensitivity C-reactive protein. | This study assessed the effect of ezetimibe coadministered with simvastatin on high-sensitivity C-reactive protein (hs-CRP) in patients with primary hypercholesterolemia. After dietary stabilization, a 2- to 12-week washout period, and a 4-week, single-blind, placebo lead-in period, patients with baseline low-density l... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | [
1,
1,
1,
1,
1,
1,
0,
1
] | 934 |
2,986,300 | Comparison of the antihypertensive effect of enalapril and propranolol in black South Africans. | Angiotensin-converting enzyme (ACE) inhibitors are useful antihypertensive agents. Enalapril maleate is a new ACE inhibitor with actions similar to those of captopril but with fewer side-effects. A study was conducted on 19 black South Africans with mild or moderate essential hypertension; enalapril was compared with p... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 935 |
35,415,009 | Treatment Patterns in Essential Tremor: A Retrospective Analysis. | Although first line therapies for essential tremor have been identified from small clinical trials, responses are variable. We conducted a survey of tremor management in a large sample of ET cases. The Movement Disorders Clinical Case Registry within a US Veterans Health Administration medical center was used to identi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 936 |
23,464,862 | Use of statins and prostate cancer recurrence among patients treated with radical prostatectomy. | WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Statins have shown broad spectrum anti-cancer properties in laboratory studies. In epidemiological studies, use of statins has been associated with reduced risk of advanced prostate cancer. However, the effects of statins on prostate cancer disease progression ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 937 |
35,418,080 | Four cycles of R-CHOP followed by two applications of rituximab based on negative interim PET/CT: an analysis of a prospective trial. | R-CHOP with or without radiotherapy is the standard treatment for limited-stage diffuse large B-cell lymphoma (DLBCL). To prevent overtreatment, we assessed whether four cycles of CHOP plus six applications of rituximab was adequate with negative interim PET/CT and the role of consolidation radiotherapy specifically fo... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 938 |
22,994,379 | An investigational ovarian stimulation protocol increased significantly the psychological burden in women with premature ovarian failure. | To assess the psychological impact (Hospital Anxiety and Depression Scale) of an investigational ovarian stimulation protocol in women with premature ovarian failure (POF). Prospective longitudinal study. Ten women with POF. Women with idiopathic POF were placed on three consecutive treatment cycles consisting of gonad... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 939 |
6,372,839 | Development of congestive heart failure after treatment with metoprolol in acute myocardial infarction. | In a double blind study of metoprolol in the treatment of suspected acute myocardial infarction 698 patients (study group) received metoprolol and 697 a placebo (control group). Metoprolol was given in an intravenous dose of 15 mg as soon as possible after admission to hospital followed by 50 g by mouth four times a da... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 940 |
3,079,066 | Conversion from cyclosporine to azathioprine improves renal function without increased risk of graft failure. | Thirty of 110 HLA-mismatched renal allograft recipients were converted from CsA to Aza due to CsA nephrotoxicity or side effects, persistent posttransplant ATN, noncompliance, or patient desire to reduce the cost of maintenance immunosuppression. The majority of patients studied were cadaver transplant recipients. Rena... | Train | 3 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | [
1,
1,
0,
0,
0,
1,
1,
0
] | 942 |
30,115,129 | ETV6/RUNX1-positive childhood acute lymphoblastic leukemia in China: excellent prognosis with improved BFM protocol. | In childhood B-precursor acute lymphoblastic leukemia (B-ALL), the ETV6/RUNX1 fusion transcript is considered to have an excellent outcome. However, few studies of children with ETV6/RUNX1-positive ALL from China have been conducted. It is largely unknown whether clinical outcomes for patients with this genotype and im... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 943 |
16,869,445 | Effects of atorvastatin and atorvastatin withdrawal on soluble CD40L and adipocytokines in patients with hypercholesterolaemia. | Beyond lipid lowering, statins have pleiotropic effects with favourable benefits against atherogenesis. Withdrawal of statin therapy has been demonstrated to abrogate vascular protective activity and even increase the incidence of thrombotic vascular events. The purpose of this study is to investigate the serial change... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 944 |
12,826,434 | Use of isotonic nebulised magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomised placebo-controlled trial. | Intravenous magnesium can cause bronchodilation in treatment of severe asthma, however its effect by the nebulised route is uncertain. We aimed to assess the effectiveness of isotonic magnesium sulphate as an adjuvant to nebulised salbutamol in severe attacks of asthma. We enrolled 52 patients with severe exacerbations... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 945 |
31,548,894 | Analysis of serious adverse events in a paediatric fast breathing pneumonia clinical trial in Malawi. | Pneumonia is the leading infectious killer of children. We conducted a double-blind, randomised controlled non-inferiority trial comparing placebo to amoxicillin treatment for fast breathing pneumonia in HIV-negative children aged 2-59 months in Malawi. Occurrence of serious adverse events (SAEs) during the trial were ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 947 |
23,235,801 | Phase III study of ACVBP versus ACVBP plus rituximab for patients with localized low-risk diffuse large B-cell lymphoma (LNH03-1B). | The superiority of a chemotherapy with doxorubicin, cyclophosphamide, vindesine, bleomycin and prednisone (ACVBP) in comparison with cyclophosphamide, doxorubicin, vincristin and prednisone plus radiotherapy for young patients with localized diffuse large B-cell lymphoma (DLBCL) was previously demonstrated. We report t... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 948 |
3,331,264 | The effect of prostacyclin on asthma precipitated by aspirin. | Inhibition of prostacyclin biosynthesis by aspirin might be expected to promote asthmatic attacks in aspirin-intolerant patients. In vitro, prostacyclin inhibits generation of leukotrienes and opposes their bronchoconstrictive action. In a double-blind study we compared the effects of intravenous infusions of prostacyc... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 949 |
22,326,828 | [Intratarsal triamcinolone acetonide injection for treatment of refractory chronic tropical endemic limboconjunctivitis (TELC): experience at Aristide-Le-Dantec university hospital in Dakar]. | To evaluate the efficacy of intratarsal triamcinolone acetonide (TA) injection versus dexamethasone ointment in the treatment of refractory chronic tropical endemic limboconjunctivitis (TELC). This one-year prospective study enrolled 20 patients with refractory TELC. One millilitre containing 40 mg TA was injected intr... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 950 |
2,470,000 | [Risk-adapted therapy of highly malignant non-Hodgkin's lymphomas with COP-BLAM/IMVP-16: a prospective multicenter study]. | In a prospective multicenter therapy trial the remission-inducing potential of the COP-BLAM (5 courses) and the possibly not cross-resistant IMVP-16 (2 courses) regimen for advanced diffuse large cell lymphomas were investigated. Inadequately responding patients were switched early after 2-3 courses to the IMVP-16 prot... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 951 |
11,920,496 | Somatostatin analogs and prednisone in advanced refractory thymic tumors. | Therapeutic options to cure advanced, recurrent, and metastatic thymic tumors are limited. Evidence of a high uptake of indium-labeled octreotide ((111)In-DTPA-D-Phe(1)-octreotide) in thymic tumors and the curative application of somatostatin analogs and prednisone in one patient with thymoma and pure red cell aplasia ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 952 |
25,917,998 | Does levothyroxine administration impact parathyroid localization? | Proper localization is crucial in performing minimally invasive parathyroidectomy for primary hyperparathyroidism. Ultrasonography (US) and Tc-99m sestamibi (MIBI) scintigraphy are common methods used for localization. As the appearance and activity of the thyroid gland may impact parathyroid localization, the purpose ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 953 |
2,719,459 | Multicenter randomized study of single-dose ofloxacin versus amoxicillin-probenecid for treatment of uncomplicated gonococcal infection. | The safety and efficacy of ofloxacin, 400 mg orally, were compared with those of amoxicillin, 3.0 g, plus probenecid, 1.0 g orally, as single-dose therapy in 201 heterosexual patients (101 men and 100 women) with uncomplicated gonococcal infection. Treatment groups were comparable in age, duration of symptoms, number o... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 954 |
24,842,643 | [A case study regarding the use of antibiotic therapies for the treatment of preterm premature rupture of fetal membranes, and emergence of antibiotic resistant bacteria]. | The objective of this retrospective study is to compare two types of antimicrobial management used to treat premature rupture of membranes in pregnancy. This study evaluates both duration and the type of antibiotic therapy used for treatment. The antimicrobials used to treat premature rupture of membranes include a fir... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 955 |
32,450,123 | Association between methylphenidate treatment and risk of seizure: a population-based, self-controlled case-series study. | Individuals with attention-deficit hyperactivity disorder (ADHD) are at increased risk of seizures. Stimulant medications such as methylphenidate are the most commonly prescribed treatment for ADHD, but the association between their therapeutic use and the risk of seizures is unclear. We aimed to investigate the associ... | Train | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
0,
1,
1,
1,
1,
1,
0
] | 959 |
30,278,522 | Effects of postoperative non-steroidal anti-inflammatory drugs on long-term survival and recurrence of patients with non-small cell lung cancer. | Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve postoperative fever, surgery pain, and inflammation. In addition, NSAIDs have anticancer activity and may reduce the risk and mortality of several cancers. However, the association between postoperative NSAIDs and the clinical outcome of non-smal... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 960 |
26,292,959 | Effect of pre-procedural interrupted apixaban on heparin anticoagulation during catheter ablation for atrial fibrillation: a prospective observational study. | Effective intraprocedural anticoagulation is considered essential to minimize the risk of thromboembolism in catheter ablation (CA) of atrial fibrillation (AF). The effect of interrupted apixaban on intraprocedural heparin dosing requirements and levels of achieved anticoagulation with heparin has not been well studied... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 961 |
2,879,629 | Efficacy of beta-blockers in migraine. A critical review. | Five double-blind trials of the prophylactic treatment of migraine with beta-blockers were reviewed critically with regard to problem investigated, design, "blindness" of patient, side effects, statistical validity, and conclusions. The initial use of a "responder-finding" period may limit the validity of results from ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 962 |
14,966,817 | Pulmonary function in bronchopulmonary dysplasia. | The purpose of this study was to examine lung function and bronchodilator responsiveness in infants with a history of prematurity and bronchopulmonary dysplasia (BPD), using the raised volume rapid thoracoabdominal compression technique as well as with whole-body plethysmography. Spirometric measurements were obtained ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | [
1,
1,
1,
1,
1,
0,
1,
1
] | 963 |
32,668,469 | [Antithrombotic Therapy in Patients with Acute Coronary Syndrome and Atrial Fibrillation]. | The number of patients with atrial fibrillation (AF) is increasing due to the aging of the population. In addition, the number of patients with AF and an indication for oral anticoagulation (OAC) for the prevention of strokes increases, who are in need for a dual antiplatelet therapy (DAPT) with acetyl salicylic acid (... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
1,
1,
1,
0,
1,
0,
0
] | 964 |
21,122,542 | Combination of thiopurines and allopurinol: adverse events and clinical benefit in IBD. | Allopurinol has been presented as a safe and effective adjunct to thiopurine therapy in inflammatory bowel disease (IBD). We aimed to determine the rate of infectious complications and clinical successes with a combination of thiopurine/allopurinol in IBD, and to identify which variables predict 6-thioguanine, 6-methyl... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 965 |
16,351,524 | Gabapentin is effective in the treatment of cancer-related neuropathic pain: a prospective, open-label study. | Gabapentin has been evaluated in the treatment of nonmalignant neuropathic pain, however, there is little direct evidence evaluating its efficacy in cancer-related neuropathic pain. This study evaluated the effectiveness of gabapentin to treat cancer-related neuropathic pain. This was an open-label study. Two parallel ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 966 |
3,099,944 | Chemoprophylaxis with oral amoxycillin against bacterial endocarditis: when should second doses be administered after dentistry? | The adequacy of serum bactericidal activity after oral amoxycillin given as prophylaxis against infective endocarditis was studied using a double blind randomised protocol in healthy volunteers having dentistry. One hour before their procedure 38 patients received 3 g amoxycillin syrup and 12 received matching placebo.... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 967 |
32,591,943 | Optimizing the MIC breakpoints of amoxicillin and tetracycline for antibiotic selection in the rescue therapy of H. pylori with bismuth quadruple regimen. | H. pylori with triple-drug resistance (TR) to clarithromycin, metronidazole, and levofloxacin limits the success of rescue therapy. We aimed to identify the optimal breakpoints of antibiotic minimal inhibitory concentration (MIC) to predict the success of rescue therapy for TR H. pylori infection. We consecutively enro... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 968 |
25,770,147 | Statin use and survival after colorectal cancer: the importance of comprehensive confounder adjustment. | Statins have been associated with moderate reductions in mortality among colorectal cancer (CRC) patients, but these studies lacked adjustment for some potentially relevant factors associated with statin use. We aimed to provide more detailed results on this association from a population-based patient cohort study. Use... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 969 |
10,919,683 | Clinical efficacy and safety of fluticasone propionate 250 microg twice daily administered via a HFA 134a pressurized metered dose inhaler to patients with mild to moderate asthma. French study group. | This study compared the efficacy and safety of the fluticasone propionate 125 microg pressurized metered dose inhaler (pMDI) propelled by either hydrofluoroalkane (HFA) 134a or chlorofluorocarbon (CFC) propellants, in adult patients with asthma. HFA 134a is a non-ozone depleting propellant used as a replacement for the... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 971 |
15,766,466 | [Veracity of smokers' reports of abstinence at smoking cessation clinics]. | To assess the reliability of smokers' response as criteria for measuring abstinence and the necessity or not of confirming abstinence with carbon monoxide (CO) measurement. A multicenter, prospective, longitudinal study was carried out on patients over 18 years of age from 5 smoking cessation clinics who underwent trea... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 972 |
15,837,945 | Body build and risk of cardiovascular events in hypertension and left ventricular hypertrophy: the LIFE (Losartan Intervention For Endpoint reduction in hypertension) study. | Obesity may independently increase the risk of adverse events in hypertension with target-organ damage. We investigated whether body build was independently associated with higher cardiovascular risk and whether treatment with losartan relative to atenolol influenced the impact of body build on the primary composite en... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 974 |
8,578,180 | Esophageal motility disorders and their coexistence with pathologic acid reflux in patients with noncardiac chest pain. | The aim of this study was to determine which motility data of patients with noncardiac chest pain (NCCP) differ from those of controls on the basis of long-term manometry and to evaluate the coexistence of motility disorders and pathologic acid reflux. Further, motility disorders were tested as to whether they were sec... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 976 |
26,558,731 | Serum oxidized low-density lipoprotein decreases in response to statin therapy and relates independently to reductions in coronary plaque in patients with HIV. | Circulating oxidized low-density lipoprotein (oxLDL) levels are elevated in HIV-infected patients and have been associated with atherosclerosis. Statins have been shown to reduce plaque on coronary computed tomography angiography (cCTA) in HIV-infected individuals. Thus, we investigated the effect of statins on serum o... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 977 |
26,720,026 | Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial. | For treatment of malignant pleural effusion, nonsteroidal anti-inflammatory drugs (NSAIDs) are avoided because they may reduce pleurodesis efficacy. Smaller chest tubes may be less painful than larger tubes, but efficacy in pleurodesis has not been proven. To assess the effect of chest tube size and analgesia (NSAIDs v... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 979 |
17,157,123 | The effect of losartan and amlodipine on serum adiponectin in Japanese adults with essential hypertension. | Adiponectin, an adipocyte-derived protein, is reduced in patients with hypertension and insulin resistance (IR). Angiotensin II receptor blockers (ARBs) have been reported to improve IR and reduce albuminuria. The purpose of this study was to evaluate the influence of an ARB and a calcium channel blocker on serum adipo... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 980 |
8,566,592 | Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulceration. | The pathogenesis of gastric metaplasia (GM) in the duodenum is unclear. The aim of this investigation was to study the effect on the extent of GM of ulcer healing, Helicobacter pylori eradication, and acid suppression singly and in combination. The relationship between GM and gastroduodenal inflammation and H. pylori i... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | [
1,
1,
1,
1,
1,
0,
0,
0
] | 982 |
19,383,644 | Vitamin D status and effect of low-dose cholecalciferol and high-dose ergocalciferol supplementation in multiple sclerosis. | Vitamin D is important for bone health and immune regulation, and has been shown to be low in multiple sclerosis (MS). We sought to determine the effect of over the counter low dose cholecalciferol (LDC) and high dose ergocalciferol (HDE) on the vitamin D levels in MS patients. We retrospectively evaluated serum 25-hyd... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 983 |
19,192,987 | Efficacy and safety of the single pill combination of amlodipine 10 mg plus valsartan 160 mg in hypertensive patients not controlled by amlodipine 10 mg plus olmesartan 20 mg in free combination. | For patients with moderate hypertension (grade 2, defined as systolic blood pressure [SBP] 160-179 mmHg and/or diastolic blood pressure [DBP] 100-109 mmHg), current guidelines recommend initial combination therapy and rapid dose-adjustment to achieve blood pressure goal. In this study we investigated the efficacy and t... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 987 |
15,995,512 | Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response. | Laryngopharyngeal reflux (LPR) is frequently treated with empiric proton-pump inhibitors (PPI), but the optimal dosing and duration is unknown. We performed an open label prospective cohort study to evaluate whether twice-daily (BID) PPI is more effective than once-daily (QD) PPI for the treatment of LPR. Patients diag... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
1,
0,
1,
1,
1,
0
] | 988 |
22,456,311 | Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction. | Striking evidence indicates endothelial impairment in polycystic ovary syndrome (PCOS) but the mechanisms linking PCOS status to cardiovascular risk remain elusive. Platelet/endothelial cell adhesion molecule (PECAM)-1 is a soluble (s) signaling molecule involved in inflammation and angiogenesis with predictive value f... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 989 |
18,492,070 | Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapy. | We investigated tolerability and efficacy of ezetimibe treatment (10 mg/d) in 25 heart allograft recipients already on stable statin therapy. Total cholesterol (TC), low-density cholesterol (LDL-C), high-density cholesterol (HDL-C), triglycerides (TG), immunosuppressant drug levels, laboratory and clinical parameters w... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 991 |
34,187,236 | Mediational g-formula for time-varying treatment and repeated-measured multiple mediators: Application to atorvastatin's effect on cardiovascular disease via cholesterol lowering and anti-inflammatory actions in elderly type 2 diabetics. | Modern causal mediation theory has formalized several types of indirect and direct effects of treatment on outcomes regarding specific mediator variables. We reviewed and unified distinct approaches to estimate the "interventional" direct and indirect effects for multiple mediators and time-varying variables. This stud... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 992 |
7,600,744 | Is ACE inhibition with lisinopril helpful in diabetic neuropathy? | Thirteen diabetic patients with hypertension (mean diastolic blood pressure 96.2 +/- 1.1 mmHg) were included in a study to assess the effects of lisinopril (20 mg day-1) on measures of nerve function. Patients had nerve conduction velocity (NCV), temperature discrimination threshold (TDT), and vibration perception thre... | Train | 3 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | [
1,
0,
1,
0,
1,
1,
0,
0
] | 993 |
9,468,251 | A placebo-controlled dose-ranging study of lansoprazole in the management of reflux esophagitis. | We compared the efficacy of three different doses of the proton pump inhibitor lansoprazole in the management of reflux esophagitis. Two hundred ninety-two patients with endoscopically confirmed reflux esophagitis were enrolled in a double-blind, multicenter study and were randomized to lansoprazole 15, 30, or 60 mg or... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 994 |
1,425,870 | The effects of omeprazole-induced hypochlorhydria on absorption of theophylline from a sustained-release formulation. | The present study was designed to investigate the effects of raised intragastric pH on the absorption of theophylline from a sustained-release formulation. Six healthy male volunteers participated in the cross-over randomised study and on one of two occasions were pretreated with 240 mg omeprazole, administered in thre... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 995 |
24,498,412 | Peptic ulcer disease risk in chronic kidney disease: ten-year incidence, ulcer location, and ulcerogenic effect of medications. | We aimed at determining peptic ulcer disease (PUD) incidence among chronic kidney disease (CKD) patients during 1998-2008, compared to patients without CKD, and at examining associations between CKD and PUD. Data for 1998-2008 were extracted from the National Health Insurance Research Database in Taiwan. The annual PUD... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 996 |
9,766,764 | Short-term augmentation of fluoxetine with clonazepam in the treatment of depression: a double-blind study. | Because selective serotonin reuptake inhibitors (SSRIs) require 2-4 weeks to reach efficacy, the authors determined whether clonazepam augmentation of fluoxetine is superior to fluoxetine alone at the beginning of treatment for major depression. Eighty adult outpatients with major depression who were rated as "moderate... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 997 |
324,258 | Sodium intake and furosemide administration in hypertensive patients with renal insufficiency. | The effects of various levels of sodium intake and loop diuretic (furosemide) administration upon arterial pressure and renal function were studied in 11 patients with impaired renal function and essential hypertension. The patients were hospitalized in a metabolic ward and continued taking their usual antihypertensive... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 998 |
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