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11418519
["Span: oncology | Label: Comorbidity"]
[Title]: The effect of amiloride on amphotericin B-induced hypokalaemia. [Abstract]: Amiloride was administered to 19 oncology patients exhibiting marked amphotericin B-induced electrolyte wasting. Mean serum potassium concentrations increased in the 5 days preceding and following administration (3.4 +/- 0.5 versus 3.9...
11419566
["Span: 30 to 60 mg by weight or a 50-mg fixed dose once daily | Label: Dosage"]
[Title]: Efficacy of metrifonate in improving the psychiatric and behavioral disturbances of patients with Alzheimer's disease. [Abstract]: Neuropsychiatric and behavioral symptoms are frequent and problematic components of Alzheimer's disease (AD). In two previously reported studies, metrifonate was shown to benefit b...
11422148
["Span: adults aged 15-85 years | Label: Age", "Span: children aged 6-14 years | Label: Age", "Span: 10 mg | Label: Dosage", "Span: 5 mg | Label: Dosage"]
[Title]: Long-term asthma control with oral montelukast and inhaled beclomethasone for adults and children 6 years and older. [Abstract]: BACKGROUND: Leukotriene receptor antagonists have demonstrated clinical benefits in chronic asthma studies of up to 3 months in duration. The effects of these agents over extended pe...
11422148
["Span: adults aged 15-85 years | Label: Age", "Span: children aged 6-14 years | Label: Age", "Span: 200 microg twice daily | Label: Dosage", "Span: 100 microg or equivalent three times daily | Label: Dosage"]
[Title]: Long-term asthma control with oral montelukast and inhaled beclomethasone for adults and children 6 years and older. [Abstract]: BACKGROUND: Leukotriene receptor antagonists have demonstrated clinical benefits in chronic asthma studies of up to 3 months in duration. The effects of these agents over extended pe...
1142528
["Span: 12.5 mg. chlorotrianisene per day | Label: Dosage"]
[Title]: Hydroxyurea in stage D carcinoma of the prostate: a pilot study. [Abstract]: There was 13 patinets with histologically metastatic prostatic adenocarcinoma treated with a single oral dose of 80 mg. per kg. hydroxyurea every third day (based on ideal or actual weight, whichever is less) and 12.5 mg. chlorotriani...
1142528
["Span: a single oral dose of 80 mg. per kg. hydroxyurea every third day | Label: Dosage"]
[Title]: Hydroxyurea in stage D carcinoma of the prostate: a pilot study. [Abstract]: There was 13 patinets with histologically metastatic prostatic adenocarcinoma treated with a single oral dose of 80 mg. per kg. hydroxyurea every third day (based on ideal or actual weight, whichever is less) and 12.5 mg. chlorotriani...
11427639
["Span: 250 mg | Label: Dosage"]
[Title]: A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. [Abstract]: BACKGROUND: Muscle cramps that improve after carnitine or vitamin E therapies are common in haemodialysis (HD) patients. Because vitamin C participates in...
11427639
["Span: 400 mg | Label: Dosage"]
[Title]: A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. [Abstract]: BACKGROUND: Muscle cramps that improve after carnitine or vitamin E therapies are common in haemodialysis (HD) patients. Because vitamin C participates in...
11429035
["Span: 500 mg tid on a compassionate-use basis | Label: Dosage"]
[Title]: Famciclovir treatment of hepatitis B infection following liver transplantation: a long-term, multi-centre study. [Abstract]: Famciclovir is a novel guanosine nucleoside analogue with activity against herpes viruses and hepatitis B virus (HBV). Several preliminary reports have described efficacy of famciclovir ...
11432448
["Span: 0.03 microM | Label: Dosage"]
[Title]: Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. [Abstract]: Mast cell histamine (HA) and cysteinyl leukotrienes (CysLT) account for most of the early phase bronchospasm in asthma. However, activation of the smooth muscle CysLT1-recepto...
11432448
["Span: 1 microM | Label: Dosage"]
[Title]: Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus. [Abstract]: Mast cell histamine (HA) and cysteinyl leukotrienes (CysLT) account for most of the early phase bronchospasm in asthma. However, activation of the smooth muscle CysLT1-recepto...
11432626
["Span: starting from 60 mg/m2 and with stepwise increments of 5 mg/m2 | Label: Dosage"]
[Title]: Phase I study of a weekly schedule of oxaliplatin, high-dose leucovorin, and infusional fluorouracil in pretreated patients with advanced colorectal cancer. [Abstract]: PURPOSE: To identify the maximum tolerated dose (MTD) and dose limiting toxicities (DLT) of oxaliplatin (L-OHP) given on a weekly schedule inc...
11432626
["Span: 500 mg/m2 | Label: Dosage"]
[Title]: Phase I study of a weekly schedule of oxaliplatin, high-dose leucovorin, and infusional fluorouracil in pretreated patients with advanced colorectal cancer. [Abstract]: PURPOSE: To identify the maximum tolerated dose (MTD) and dose limiting toxicities (DLT) of oxaliplatin (L-OHP) given on a weekly schedule inc...
11432626
["Span: 2600 mg/m2 | Label: Dosage"]
[Title]: Phase I study of a weekly schedule of oxaliplatin, high-dose leucovorin, and infusional fluorouracil in pretreated patients with advanced colorectal cancer. [Abstract]: PURPOSE: To identify the maximum tolerated dose (MTD) and dose limiting toxicities (DLT) of oxaliplatin (L-OHP) given on a weekly schedule inc...
11434939
["Span: 0.03% once a day | Label: Dosage", "Span: 0.03% twice a day | Label: Dosage"]
[Title]: Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. [Abstract]: The efficacy and safety of bimatoprost, a member of a new class of pharmacological agents called prostamides, were compared with the efficacy and safety of timolol...
11434939
["Span: 0.03% once a day | Label: Dosage", "Span: 0.03% twice a day | Label: Dosage"]
[Title]: Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. [Abstract]: The efficacy and safety of bimatoprost, a member of a new class of pharmacological agents called prostamides, were compared with the efficacy and safety of timolol...
11434939
["Span: 0.5% BID | Label: Dosage"]
[Title]: Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. [Abstract]: The efficacy and safety of bimatoprost, a member of a new class of pharmacological agents called prostamides, were compared with the efficacy and safety of timolol...
11434939
["Span: 0.5% BID | Label: Dosage"]
[Title]: Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure. [Abstract]: The efficacy and safety of bimatoprost, a member of a new class of pharmacological agents called prostamides, were compared with the efficacy and safety of timolol...
11435324
["Span: 200 mg/d; 200 mg increment every 2 weeks to 800 mg | Label: Dosage"]
[Title]: Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients. [Abstract]: This report of a phase 2 trial of thalidomide (THAL) (200 mg/d; 200 mg increment every 2 weeks to 800 mg) for 169 patients with adva...
11440936
[]
[Title]: Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. [Abstract]: OBJECTIVE: To quantify the antiemetic efficacy and adverse effects of cannabis used for sickness induced by chemotherapy. DESIGN: Systematic review. DATA SOURCES: Systematic search (Medline, Embase...
11440936
[]
[Title]: Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. [Abstract]: OBJECTIVE: To quantify the antiemetic efficacy and adverse effects of cannabis used for sickness induced by chemotherapy. DESIGN: Systematic review. DATA SOURCES: Systematic search (Medline, Embase...
11442886
["Span: 9.4 +/- 3.6 mg/day | Label: Dosage"]
[Title]: Efficacy and safety of olanzapine, an atypical antipsychotic, in patients with schizophrenia: results of an open-label multicenter study in Japan. [Abstract]: This first clinical study of olanzapine in Japanese patients with schizophrenia was conducted to investigate the efficacy and safety of olanzapine. Eigh...
11443577
[]
[Title]: A multicenter study of lamivudine treatment in 33 patients with hepatitis B after liver transplantation. [Abstract]: Hepatitis B virus (HBV) infection after liver transplantation (LT) may lead to severe and rapidly progressive graft failure. Antiviral treatment may be of benefit in selected patients with recur...
11443583
[]
[Title]: Beneficial effects of converting liver transplant recipients from cyclosporine to tacrolimus on blood pressure, serum lipids, and weight. [Abstract]: Hypertension and hyperlipidemia are more prevalent after liver transplantation with cyclosporine as the primary immunosuppressive agent compared with tacrolimus....
11446944
[]
[Title]: [Anesthetic management for cesarean delivery in a pregnant patient with congenital antithrombin III deficiency and pulmonary thromboembolism]. [Abstract]: Antithrombin III (AT III) deficiency is a rare hereditary disease that predisposes a patient to thromboembolic complications. Anticoagulation is essential f...
11448321
["Span: 0.003%, 0.01%, or 0.03% AGN 192024 were given once daily for 3 weeks then twice daily for 1 week | Label: Dosage"]
[Title]: Comparison of the ocular hypotensive lipid AGN 192024 with timolol: dosing, efficacy, and safety evaluation of a novel compound for glaucoma management. [Abstract]: OBJECTIVE: To compare the safety and efficacy of the ocular hypotensive lipid AGN 192024 (Lumigan) with those of timolol. METHODS: A 30-day, rando...
11448321
["Span: 0.5% timolol was given twice daily for 4 weeks | Label: Dosage"]
[Title]: Comparison of the ocular hypotensive lipid AGN 192024 with timolol: dosing, efficacy, and safety evaluation of a novel compound for glaucoma management. [Abstract]: OBJECTIVE: To compare the safety and efficacy of the ocular hypotensive lipid AGN 192024 (Lumigan) with those of timolol. METHODS: A 30-day, rando...
11452896
["Span: 2 x 25 mg | Label: Dosage"]
[Title]: [Does early high dosage dipyridamole in prevention of secondary stroke induce cardiac events?]. [Abstract]: In a post hoc analysis of the European Stroke Prevention Study 2 (ESPS2), we investigated whether dipyridamole given as antiplatelet drug in patients with TIA or stroke increases the risk of cardiac even...
11452896
["Span: 2 x 200 mg | Label: Dosage"]
[Title]: [Does early high dosage dipyridamole in prevention of secondary stroke induce cardiac events?]. [Abstract]: In a post hoc analysis of the European Stroke Prevention Study 2 (ESPS2), we investigated whether dipyridamole given as antiplatelet drug in patients with TIA or stroke increases the risk of cardiac even...
11454181
["Span: five with genotype 1 and one with genotype 4 | Label: Gene", "Span: average daily doses of 170-300 mg | Label: Dosage"]
[Title]: Ribavirin treatment in dialysis patients with chronic hepatitis C virus infection--a pilot study. [Abstract]: Standard treatment for chronic hepatitis C is with interferon (IFN)-alpha and ribavirin for 6-12 months. In dialysis patients only interferon therapy is currently used due to the lack of knowledge conc...
11456310
["Span: 47,351 men and 88,565 women | Label: Gender"]
[Title]: Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. [Abstract]: Results of case-control studies and of a prospective investigation in men suggest that consumption of coffee could protect against the risk of Parkinson's disease, but the active constituent is not clear. To...
11461176
[]
[Title]: Concurrent administration of sustained-release bezafibrate may counteract the increased thrombotic risk associated with oral estrogen therapy. [Abstract]: Although hormone replacement therapy (HRT) can have many favorable effects on serum lipids and on vascular endothelium that presumably mediate the decreased...
11465651
["Span: African American | Label: Body Type", "Span: 320 mg/day | Label: Dosage", "Span: 160 mg/day | Label: Dosage"]
[Title]: Valsartan alone or with a diuretic or ACE inhibitor as treatment for African American hypertensives: relation to salt intake. [Abstract]: Previous clinical trials have demonstrated the important influence of ethnicity and dietary salt on the antihypertensive efficacy of drugs that block the renin angiotensin s...
11465651
["Span: African American | Label: Body Type", "Span: 12.5 mg/day | Label: Dosage"]
[Title]: Valsartan alone or with a diuretic or ACE inhibitor as treatment for African American hypertensives: relation to salt intake. [Abstract]: Previous clinical trials have demonstrated the important influence of ethnicity and dietary salt on the antihypertensive efficacy of drugs that block the renin angiotensin s...
11470055
["Span: 5 to 10 mg/day | Label: Dosage"]
[Title]: [Olanzapine efficacy in the treatment of cocaine abuse in methadone maintenance patients. Interaction with plasma levels]. [Abstract]: INTRODUCTION: The aim of this study was to evaluate the efficacy of the treatment with antipsychotic olanzapine in cocaine abuse methadone patients. The decrease or interruptio...
11470055
[]
[Title]: [Olanzapine efficacy in the treatment of cocaine abuse in methadone maintenance patients. Interaction with plasma levels]. [Abstract]: INTRODUCTION: The aim of this study was to evaluate the efficacy of the treatment with antipsychotic olanzapine in cocaine abuse methadone patients. The decrease or interruptio...
1147074
[]
[Title]: Deanol in the treatment of tardive dyskinesia. [Abstract]: A patient who developed severe tardive dyskinesia after the termination of long-term phenothiazine therapy was successfully treated with deanol, a possible precursor of acetylcholine. Physiological measurements were obtained to quantify the clinical co...
11472356
["Span: 0.4 mg/kg/d | Label: Dosage"]
[Title]: Cyclosporin A for the treatment of patients with chronic idiopathic thrombocytopenic purpura refractory to corticosteroids or splenectomy. [Abstract]: Patients with chronic immune thrombocytopenic purpura (ITP) who are unresponsive to corticosteroids require splenectomy, but if this fails, treatment is difficu...
11472356
["Span: 5 mg/kg/d | Label: Dosage"]
[Title]: Cyclosporin A for the treatment of patients with chronic idiopathic thrombocytopenic purpura refractory to corticosteroids or splenectomy. [Abstract]: Patients with chronic immune thrombocytopenic purpura (ITP) who are unresponsive to corticosteroids require splenectomy, but if this fails, treatment is difficu...
11472706
["Span: 10 mg | Label: Dosage"]
[Title]: Effect of niacin and atorvastatin on lipoprotein subclasses in patients with atherogenic dyslipidemia. [Abstract]: This study was conducted to determine the efficacy of atorvastatin and niacin on lipoprotein subfractions in patients with atherogenic dyslipidemia. This was a multicenter, randomized, open-label,...
11472706
["Span: 3,000 mg daily for 12 weeks | Label: Dosage"]
[Title]: Effect of niacin and atorvastatin on lipoprotein subclasses in patients with atherogenic dyslipidemia. [Abstract]: This study was conducted to determine the efficacy of atorvastatin and niacin on lipoprotein subfractions in patients with atherogenic dyslipidemia. This was a multicenter, randomized, open-label,...
11473503
["Span: 150-250 mg daily | Label: Dosage", "Span: 65 males, 91 females | Label: Gender", "Span: aged 18-65 | Label: Age"]
[Title]: Moclobemide vs. imipramine in bipolar depression: a multicentre double-blind clinical trial. [Abstract]: OBJECTIVE: To determine the relative efficacy, tolerability and risk of precipitating mania of moclobemide and imipramine in the treatment of bipolar depression. METHOD: A randomized, double-blind, parallel...
11473503
["Span: 450-750 mg daily | Label: Dosage", "Span: 65 males, 91 females | Label: Gender", "Span: aged 18-65 | Label: Age"]
[Title]: Moclobemide vs. imipramine in bipolar depression: a multicentre double-blind clinical trial. [Abstract]: OBJECTIVE: To determine the relative efficacy, tolerability and risk of precipitating mania of moclobemide and imipramine in the treatment of bipolar depression. METHOD: A randomized, double-blind, parallel...
11476129
["Span: mean age, 16.3 years; range, 10-36 years | Label: Age", "Span: mean daily dose, 128.4 mg; range, 100-150 mg | Label: Dosage"]
[Title]: Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. [Abstract]: Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined. It was h...
11476129
["Span: mean age, 16.3 years; range, 10-36 years | Label: Age", "Span: mean daily dose, 1.3 mg; range, 1-1.5 mg | Label: Dosage"]
[Title]: Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. [Abstract]: Clomipramine, haloperidol, and placebo were compared with baseline in the treatment of autism, and overall outcome, specific symptoms, and side effects were examined. It was h...
11476131
["Span: mean age, 41.6 years; mean duration of illness, 21.7 years | Label: Age", "Span: 10 to 40 mg daily | Label: Dosage"]
[Title]: Olanzapine for schizophrenia refractory to typical and atypical antipsychotics: an open-label, prospective trial. [Abstract]: The role of olanzapine in treatment-resistant schizophrenia is still unresolved. This article presents an open-label, prospective, 14-week trial with olanzapine in patients with schizop...
11477829
[]
[Title]: [Clinical study on qiangxinling liquid extract in treating congestive heart failure]. [Abstract]: OBJECTIVE: To find the safe and effective treatment and drugs for congestive heart failure (CHF). METHODS: Ninety CHF patients whose heart function belong to III-IV grade were randomly divided into 3 groups: Group...
11479406
["Span: aged between 1 week and 13.5 months | Label: Age", "Span: ranged from 0.35 to 1.55 (mean, 0.81, median 0.79) mg. kg-1. d-1 | Label: Dosage"]
[Title]: Cisapride plasma levels and corrected QT interval in infants undergoing routine polysomnography. [Abstract]: BACKGROUND: Reported QTc prolongation associated with cardiac arrhythmia in a small number of children undergoing cisapride therapy and lack of pharmacokinetic correlation provided the impetus for this ...
11480792
["Span: 150 or 300 mg daily | Label: Dosage"]
[Title]: Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B. [Abstract]: PURPOSE: A long-term follow-up study was carried out to evaluate the tolerability and efficacy of long-term therapy (1 to 3 years) with high doses (150 or 300 mg daily) of lamivudine...
11481167
["Span: aged 18-65 years | Label: Dosage"]
[Title]: A double-blind comparative study of clozapine and risperidone in the management of severe chronic schizophrenia. [Abstract]: OBJECTIVE: This prospective, double-blind, multicenter, parallel-group study compared the efficacy and safety of therapeutic doses of clozapine and risperidone in patients with severe ch...
11481696
["Span: 10 mg | Label: Dosage", "Span: 20 mg | Label: Dosage", "Span: 40 mg | Label: Dosage"]
[Title]: Idazoxan, an alpha-2 antagonist, and L-DOPA-induced dyskinesias in patients with Parkinson's disease. [Abstract]: Dyskinesia is a frequent and disabling side effect in patients with Parkinson's disease treated with chronic dopa-therapy. Preclinical data in the 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPT...
11489769
[]
[Title]: Randomized comparison of enoxaparin, a low-molecular-weight heparin, with unfractionated heparin adjunctive to recombinant tissue plasminogen activator thrombolysis and aspirin: second trial of Heparin and Aspirin Reperfusion Therapy (HART II). [Abstract]: BACKGROUND: Adjunctive unfractionated heparin (UFH) du...
11489769
[]
[Title]: Randomized comparison of enoxaparin, a low-molecular-weight heparin, with unfractionated heparin adjunctive to recombinant tissue plasminogen activator thrombolysis and aspirin: second trial of Heparin and Aspirin Reperfusion Therapy (HART II). [Abstract]: BACKGROUND: Adjunctive unfractionated heparin (UFH) du...
11491499
["Span: 20 mg daily | Label: Dosage"]
[Title]: Glucocorticoid effects on myocardial performance in patients with systemic sclerosis. [Abstract]: OBJECTIVE: Myocardial inflammation andfibrosis are common autopsyfindings in systemic sclerosis (SSc) and, although symptomatic cardiac involvement occurs less often, current therapies remain empiric and do not pr...
11491499
["Span: 20 mg daily | Label: Dosage"]
[Title]: Glucocorticoid effects on myocardial performance in patients with systemic sclerosis. [Abstract]: OBJECTIVE: Myocardial inflammation andfibrosis are common autopsyfindings in systemic sclerosis (SSc) and, although symptomatic cardiac involvement occurs less often, current therapies remain empiric and do not pr...
11491499
["Span: 20 mg daily | Label: Dosage"]
[Title]: Glucocorticoid effects on myocardial performance in patients with systemic sclerosis. [Abstract]: OBJECTIVE: Myocardial inflammation andfibrosis are common autopsyfindings in systemic sclerosis (SSc) and, although symptomatic cardiac involvement occurs less often, current therapies remain empiric and do not pr...
11501851
["Span: 280-360 mg or more | Label: Dosage"]
[Title]: From codeine to transdermal fentanyl for cancer pain control: a safety and efficacy clinical trial. [Abstract]: BACKGROUND: Fentanyl is a synthetic opioid, suitable for transdermal delivery, offering an interesting solution as a step 3 opioid in cancer pain treatment. The purpose of the study was to carefully ...
11501851
["Span: 25 microg/hour | Label: Dosage"]
[Title]: From codeine to transdermal fentanyl for cancer pain control: a safety and efficacy clinical trial. [Abstract]: BACKGROUND: Fentanyl is a synthetic opioid, suitable for transdermal delivery, offering an interesting solution as a step 3 opioid in cancer pain treatment. The purpose of the study was to carefully ...
11501851
["Span: 5 mg | Label: Dosage"]
[Title]: From codeine to transdermal fentanyl for cancer pain control: a safety and efficacy clinical trial. [Abstract]: BACKGROUND: Fentanyl is a synthetic opioid, suitable for transdermal delivery, offering an interesting solution as a step 3 opioid in cancer pain treatment. The purpose of the study was to carefully ...
11505079
["Span: children | Label: Age", "Span: 0.84 mg/kg per day (range, 0.45-1.33 mg/kg per day) | Label: Dosage"]
[Title]: Prophylactic therapy with enoxaparin during L-asparaginase treatment in children with acute lymphoblastic leukemia. [Abstract]: Forty-one consecutive children with acute lymphoblastic leukemia (ALL) received prophylaxis therapy with the low molecular weight heparin (LMWH) enoxaparin during L-asparaginase treat...
11510750
["Span: 62+/-4 years old | Label: Dosage"]
[Title]: Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. [Abstract]: To investigate the beneficial effects of cilnidipine, a calcium channel blocker that shows high selectivity for N-type receptors, on the progression of chron...
11519776
["Span: 40 mg/d | Label: Dosage"]
[Title]: Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials. [Abstract]: BACKGROUND: The older proton pump inhibitor (PPI) omepr...
11519776
["Span: 20 mg/d | Label: Dosage"]
[Title]: Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials. [Abstract]: BACKGROUND: The older proton pump inhibitor (PPI) omepr...
11519776
["Span: 30 mg/d | Label: Dosage"]
[Title]: Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials. [Abstract]: BACKGROUND: The older proton pump inhibitor (PPI) omepr...
11519776
["Span: 20 mg/d, 0.93 (95% CI, 0.87-1.00); and pantoprazole 40 mg/d, 0.98 (95% CI, 0.90-1.07) | Label: Dosage"]
[Title]: Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials. [Abstract]: BACKGROUND: The older proton pump inhibitor (PPI) omepr...
11521799
["Span: mean age 53 years | Label: Age", "Span: 6000 MBq/m2 | Label: Dosage"]
[Title]: The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. [Abstract]: PURPOSE: The aim of this phase II study was to evaluate the tumour response of neuroendocrine tumours to targeted irradiation with the radiolabelled somatosta...
11521799
["Span: mean age 53 years | Label: Age", "Span: 6000 MBq/m2 | Label: Dosage"]
[Title]: The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. [Abstract]: PURPOSE: The aim of this phase II study was to evaluate the tumour response of neuroendocrine tumours to targeted irradiation with the radiolabelled somatosta...
11521799
[]
[Title]: The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. [Abstract]: PURPOSE: The aim of this phase II study was to evaluate the tumour response of neuroendocrine tumours to targeted irradiation with the radiolabelled somatosta...
11526364
[]
[Title]: Effect of carvedilol on survival and hemodynamics in patients with atrial fibrillation and left ventricular dysfunction: retrospective analysis of the US Carvedilol Heart Failure Trials Program. [Abstract]: BACKGROUND: Atrial fibrillation (AF) is present in a significant number of patients with congestive hear...
11526364
[]
[Title]: Effect of carvedilol on survival and hemodynamics in patients with atrial fibrillation and left ventricular dysfunction: retrospective analysis of the US Carvedilol Heart Failure Trials Program. [Abstract]: BACKGROUND: Atrial fibrillation (AF) is present in a significant number of patients with congestive hear...
11527250
["Span: 450 mg/day | Label: Dosage"]
[Title]: Effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, combined with inhaled beclomethasone in patients with moderate or severe asthma. [Abstract]: BACKGROUND: Although inhaled steroids are used as the first line of therapy in asthmatic patients, symptoms of asthma do not improve completely in s...
11527250
["Span: 1,600 microg/day | Label: Dosage", "Span: 800 microg/day | Label: Dosage"]
[Title]: Effects of pranlukast, a cysteinyl leukotriene receptor 1 antagonist, combined with inhaled beclomethasone in patients with moderate or severe asthma. [Abstract]: BACKGROUND: Although inhaled steroids are used as the first line of therapy in asthmatic patients, symptoms of asthma do not improve completely in s...
11528156
["Span: 1.0-2.0 g/day | Label: Dosage"]
[Title]: Mycophenolate mofetil in the therapy of severe myasthenia gravis. [Abstract]: Mycophenolate mofetil is a novel immunosuppressive drug already established in transplantation medicine. Recently, results of three open clinical trials on mycophenolate mofetil in myasthenia gravis have been reported. Mycophenolate ...
11528249
["Span: 300-400 mg/m(2) | Label: Dosage"]
[Title]: A phase I study of raltitrexed (Tomudex) combined with carmofur in metastatic colorectal cancer. [Abstract]: OBJECTIVES: The aim of the study was to define the maximum tolerated dose (MTD) of the combination of raltitrexed plus carmofur, and to evaluate the tolerability and efficacy of this combination in meta...
11528249
["Span: 1.5-3.0 mg/m(2) | Label: Dosage"]
[Title]: A phase I study of raltitrexed (Tomudex) combined with carmofur in metastatic colorectal cancer. [Abstract]: OBJECTIVES: The aim of the study was to define the maximum tolerated dose (MTD) of the combination of raltitrexed plus carmofur, and to evaluate the tolerability and efficacy of this combination in meta...
11529341
["Span: 6 mg | Label: Dosage"]
[Title]: Hypotension in spinal anesthesia for cesarean section: a comparison of 0.5% hyperbaric bupivacaine and 5% hyperbaric lidocaine. [Abstract]: Hypotension is a common side effect associated with spinal anesthesia. However, there is no previous report comparing the incidence of hypotension between two commonly use...
11531681
["Span: 5 ml 1% solution | Label: Dosage"]
[Title]: Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. [Abstract]: In a randomised, controlled, double-blinded trial to study the effect of ondansetron pretreatment on the pain produced after intravenous injection of ...
11531681
["Span: 4 mg (2 mg.ml-1 solution) | Label: Dosage"]
[Title]: Effect of ondansetron pretreatment on pain after rocuronium and propofol injection: a randomised, double-blind controlled comparison with lidocaine. [Abstract]: In a randomised, controlled, double-blinded trial to study the effect of ondansetron pretreatment on the pain produced after intravenous injection of ...
11532201
[]
[Title]: Digitoxin medication and cancer; case control and internal dose-response studies. [Abstract]: BACKGROUND: Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to th...
11534318
["Span: 0.65% | Label: Dosage"]
[Title]: [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]. [Abstract]: Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vi...
11534318
["Span: 0.65% | Label: Dosage"]
[Title]: [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]. [Abstract]: Pityrosporum ovale appears to play an important role in the pathogenesis of dandruff as a symptom of seborrheic dermatitis. Climbazole is an antimycotic agent with a high in vi...
11545549
["Span: 400 mg/day | Label: Dosage"]
[Title]: Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate. [Abstract]: OBJECTIVES: To assess the correlation between antiretroviral treatment and dyslipidaemia in HIV-infect...
11545549
[]
[Title]: Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate. [Abstract]: OBJECTIVES: To assess the correlation between antiretroviral treatment and dyslipidaemia in HIV-infect...
11545549
[]
[Title]: Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate. [Abstract]: OBJECTIVES: To assess the correlation between antiretroviral treatment and dyslipidaemia in HIV-infect...
11545549
[]
[Title]: Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidaemic therapy with bezafibrate. [Abstract]: OBJECTIVES: To assess the correlation between antiretroviral treatment and dyslipidaemia in HIV-infect...
11549407
[]
[Title]: A double-blind placebo-controlled crossover study of phenytoin in individuals with impulsive aggression. [Abstract]: The present study examines the behavioral and psychophysiological effects of phenytoin (PHT) in individuals who display impulsive-aggressive outbursts. In a double-blind placebo-controlled cross...
11551579
["Span: 10 mg once-daily | Label: Dosage"]
[Title]: Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study. [Abstract]: BACKGROUND: Lamivudine-resistant hepatitis B virus (HBV) is found in about 15-32% of infected patients with or without co-infection with HIV-1 after 1 ...
11551579
["Span: 150 mg twice daily | Label: Dosage"]
[Title]: Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study. [Abstract]: BACKGROUND: Lamivudine-resistant hepatitis B virus (HBV) is found in about 15-32% of infected patients with or without co-infection with HIV-1 after 1 ...
11551579
[]
[Title]: Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study. [Abstract]: BACKGROUND: Lamivudine-resistant hepatitis B virus (HBV) is found in about 15-32% of infected patients with or without co-infection with HIV-1 after 1 ...
11552226
[]
[Title]: Doxorubicin and taxane combination regimens for metastatic breast cancer: focus on cardiac effects. [Abstract]: Investigation of the combination of the taxanes with doxorubicin in the treatment of breast cancer has logically progressed, with the ultimate goal of identifying a safe and effective regimen for use...
11552226
[]
[Title]: Doxorubicin and taxane combination regimens for metastatic breast cancer: focus on cardiac effects. [Abstract]: Investigation of the combination of the taxanes with doxorubicin in the treatment of breast cancer has logically progressed, with the ultimate goal of identifying a safe and effective regimen for use...
11552226
[]
[Title]: Doxorubicin and taxane combination regimens for metastatic breast cancer: focus on cardiac effects. [Abstract]: Investigation of the combination of the taxanes with doxorubicin in the treatment of breast cancer has logically progressed, with the ultimate goal of identifying a safe and effective regimen for use...
11555353
["Span: 2 mg/day | Label: Dosage"]
[Title]: Effect of clonazepam treatment on antipsychotic drug-induced Meige syndrome and changes in plasma levels of GABA, HVA, and MHPG during treatment. [Abstract]: We demonstrated the effect of clonazepam (2 mg/day) on Meige syndrome in two schizophrenic patients under continuous treatment with antipsychotic drugs, ...
11555383
[]
[Title]: Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate. [Abstract]: OBJECTIVE: High-dose inhaled corticosteroids (ICS) have been associated with the same side-effects as oral corticosteroids. Beclomethasone dipropionate (BDP) and budesonide (BUD)...
11555383
[]
[Title]: Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate. [Abstract]: OBJECTIVE: High-dose inhaled corticosteroids (ICS) have been associated with the same side-effects as oral corticosteroids. Beclomethasone dipropionate (BDP) and budesonide (BUD)...
11555383
[]
[Title]: Improved safety with equivalent asthma control in adults with chronic severe asthma on high-dose fluticasone propionate. [Abstract]: OBJECTIVE: High-dose inhaled corticosteroids (ICS) have been associated with the same side-effects as oral corticosteroids. Beclomethasone dipropionate (BDP) and budesonide (BUD)...
11558979
["Span: 13 females and four males | Label: Gender", "Span: age 32-88 years | Label: Age", "Span: 0.4 mg/kg | Label: Dosage", "Span: 4 mg/kg | Label: Dosage"]
[Title]: Interindividual differences in the analgesic response to ketamine in chronic orofacial pain. [Abstract]: The analgesic effect of the N-methyl-D-aspartate (NMDA) receptor blocker ketamine in 17 patients (13 females and four males, age 32-88 years) who had suffered neuropathic orofacial pain for time periods ran...
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This is the official dataset for the paper "Applicability Condition Extraction for Therapeutic Drug-Disease Relations", accepted by ACL 2026 Findings.

Repository: https://github.com/guantingluo98/Drug-ACE

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