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Pure Basaloid Squamous Cell Carcinoma of the Uterine Cervix: A Case Report # Introduction Basaloid squamous carcinoma of the uterine cervix is a rare tumor type characterized by an ulcerated, infiltrating growth pattern; nests or cords of small basaloid cells; prominent peripheral palisading of cells in the tumor ce...
Understanding the mental health impact and needs of public healthcare professionals during COVID-19 in Pakistan : a qualitative study # Introduction Worldwide, health service providers are under insurmountable psychological pressures as they are expected to deal with a number of issues that arise due to the COVID-19...
Ezetimibe/Simvastatin 10/20 mg versus Rosuvastatin 10 mg in high-risk hypercholesterolemic patients stratified by prior statin treatment potency Objective: This post-hoc analysis compared the lipid-altering efficacy of Ezetimibe/Simvastatin 10/20 mg (EZ/Simva) versus Rosuvastatin 10 mg (Rosuva) in patients stratified ...
The Homeobox gene, HOXB13, Regulates a Mitotic Protein-Kinase Interaction Network in Metastatic Prostate Cancers Normal Prostate Prostate Tumor Cell line AR-ChIP seq Query DataSets for GSE56288 a. b Supplementary Figure 1. a. Flow chart: Identification of the HOXB13 direct targets in human prostate tumors. Integration...
Cuprate-like Electronic Properties in Superlattices with AgIIF2 Square Sheet Using the generalized gradient approximation augmented with maximally localized Wannier functions analysis, we present the formation of cuprate-like electronic structures in Ag II F 2 -related superlattices resulted from the confinement toget...
The Alpha Variant (B.1.1.7) of SARS-CoV-2 Failed to Become Dominant in Mexico [bib_ref] Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England, Volz [/bib_ref] [bib_ref] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding..., Starr [/bib_ref] [bib_ref] Detection ...
Early prediction of postoperative liver dysfunction and clinical outcome using antithrombin III-activity Background and aimsAntithrombin III (ATIII) has been reported to be associated with liver pathologies and was shown to predict outcome in patients undergoing liver resection for hepatocellular carcinoma. We now aim...
Evaluation of teaching effect of first-aid comprehensive simulation-based education in clinical medical students [bib_ref] A qualitative analysis of statements on motivation of applicants for medical school, Wouters [/bib_ref] [bib_ref] Basic science right, not basic science lite: medical education at a crossroad, Fi...
Septum Pellucidum Chronic Encapsulated Hematoma With Osseous Metaplasia Mimicking Recurrent Astrocytoma and Shunt-Related Foreign Body Granuloma # Introduction Chronic encapsulated intracerebral hematoma (CEIH) is a well-known complication of spontaneous intraparenchymal hemorrhage (ICH) characterized by the slow en...
Determinants of relapse periodicity in Plasmodium vivax malaria Plasmodium vivax is a major cause of febrile illness in endemic areas of Asia, Central and South America, and the horn of Africa. Plasmodium vivax infections are characterized by relapses of malaria arising from persistent liver stages of the parasite (hy...
Distinct gene expression profiles associated with the susceptibility of pathogen-specific CD4+ T cells to HIV-1 infection # Background HIV infection causes the progressive depletion of CD4+ T cells. Contrary to the early loss of CD4 response to opportunistic pathogens like Candida albicans, cytomegalovirus (CMV)-spe...
Correlation Analysis of Serum Pepsinogen, Interleukin, and TNF-α with Hp Infection in Patients with Gastric Cancer: A Randomized Parallel Controlled Clinical Study Background. Gastric cancer pathological biopsy and visual examination have been the gold standard for gastric cancer diagnosis, but their operation is cost...
Loci That Control Nonlinear, Interdependent Responses to Combinations of Drought and Nitrogen Limitation Crop improvement must accelerate to feed an increasing human population in the face of environmental changes. Including anticipated climatic changes with genetic architecture in breeding programs could better optim...
App-based symptoms screening with Xpert MTB/RIF Ultra assay used for active tuberculosis detection in migrants at point of arrivals in Italy: The E-DETECT TB intervention analysis BackgroundFrom 2014 to 2017, the number of migrants who came to Italy via the Mediterranean route has reached an unprecedented level. The m...
Co-existing Gastrointestinal Hemorrhage and Deep Vein Thrombosis in a Patient with Hereditary Hemorrhagic Telangiectasia: Management Dilemma # Introduction The incidence of an autosomal dominant disorder known as hereditary hemorrhagic telangiectasia (HHT) or Osler-Weber-Rendu disease is one in 8000 people. The comp...
Platelet-to-lymphocyte ratio as a predictive index for delirium in critically ill patients Delirium is a neuropsychiatric syndrome commonly encountered in critically ill patients, and systemic inflammation has been strongly implicated to underlie its pathophysiology. This study aimed to investigate the predictive valu...
Co-application of ACC-deaminase producing PGPR and timber-waste biochar improves pigments formation, growth and yield of wheat under drought stress Besides other deleterious effects, drought elevates ethylene level too in plants. Increased ethylene concentration reduces root elongation and development that consequentl...
Capillary leak syndrome induced by neoadjuvant cisplatin and gemcitabine in a patient with bladder cancer Capillary leak syndrome (CLS) is a rare disorder associated with an increased capillar permeability due to an endothelial damage, causing leakage of plasma and proteins into the interstitial compartment. CLS is ch...
Connected, Respected and Contributing to Their World: The Case of Sexual Minority and Non-Minority Young People in Ireland Outcome 5 of the Irish Better Outcomes, Brighter Futures national youth policy framework ("Connected, respected, and contributing to their world") offers a suitable way to study psychosocial deter...
Tobacco use and sinonasal cancer: a case-control study. The risk for sinonasal cancer associated with tobacco use was examined in a case-control study in males diagnosed between 1978 and 1981 in the Netherlands. Of the 116 cases of sinonasal cancer and 259 controls identified, interviews were completed for 92 (79%) of...
High temperature environment reduces olive oil yield and quality Global warming is predicted to have a negative effect on plant growth due to the damaging effect of high temperatures. In order to address the effect of high temperature environments on olive oil yield and quality, we compared its effect on the fruit dev...
Antidiabetic Actions of Endogenous and Exogenous GLP-1 in Type 1 Diabetic Patients With and Without Residual β-Cell Function OBJECTIVE-To investigate the effect of exogenous as well as endogenous glucagon-like peptide 1 (GLP-1) on postprandial glucose excursions and to characterize the secretion of incretin hormones i...
Mobile laminar air flow screen for additional operating room ventilation: reduction of intraoperative bacterial contamination during total knee arthroplasty Background Surgical site infections are important complications in orthopedic surgery. A mobile laminar air flow (LAF) screen could represent a useful addition to...
A multimodal approach to improve asthmatic adolescents’ self-efficacy in Taiwan Background:An efficient asthma self-management for adolescents must be based on adolescents' needs, increase self-efficacy and adherence to treatment. The effects of such program are likely be dose dependent.Aim:To examine the impact of th...
Ecology of blood stream infection and antibiotic resistance in intensive care unit at a tertiary care hospital in North India a b s t r a c tObjective: To analyse the prevalent microorganisms and their antimicrobial resistance among intensive care unit patients in a tertiary care centre in New Delhi.Methods: A retrosp...
Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis # Introduction Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, characterized by inflammation and fibrosis of the intraand extrahepatic bile ducts. ...
Alcohol-Related Brain Damage in Humans Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann's area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control subjects. H & E staining and light microscopy of prefron...
Determinants of an autism spectrum disorder diagnosis in childhood and adolescence: Evidence from the UK Millennium Cohort Study Characteristics of the MCS sample by the timing of diagnosis for autism spectrum disorder Characteristics of the MCS sample by the timing of diagnosis for autism spectrum disorder Supplement...
Leveraging community health worker system to map a mountainous rural district in low resource setting: a low-cost approach to expand use of geographic information systems for public health Background: Geographic Information Systems (GIS) have become an important tool in monitoring and improving health services, partic...
Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash The morbidity and mortality related to respiratory tract diseases is enormous, with hundreds of millions of individuals afflicted and four millio...
The Impact of Purifying and Background Selection on the Inference of Population History: Problems and Prospects SuppFigure 15: Performance of demographic inference by MSMC (red lines) and fastsimcoal2 (blue lines) under different scenarios of neutrality, when the true model is equilibrium: (a) there is variation in re...
Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection ## In brief Roussel et al. characterize the immune profile of COVID-19 + and COVID-19 À patients, both presenting an acute respiratory distress syndrome (ARDS) and COVID-19 + without ARDS. They identify ...
Kinetochores Generate Microtubules with Distal Plus Ends: Their Roles and Limited Lifetime in Mitosis Figure S1, (associated withFigure 1).(A) Schematic drawing of a CEN reactivation assay Using this assay, we can displace a centromere further away from a spindle pole. See detail in main text and inTanaka et al., 2005...
## S2 text. predicting choices using eye-fixations Several recent studies have shown that the more one look at an alternative, the more likely this alternative will be chosen . Here, we examined whether this pattern holds in our data, by predicting the probability of choosing alternative A(x 1 , p 1 ) over alternativ...
Unequal excess mortality during the Spanish Flu pandemic in the Netherlands A century after the Spanish Flu, the COVID-19 pandemic has brought renewed attention to socioeconomic and occupational differences in mortality in the earlier pandemic. The magnitude of these differences and the pathways between occupation and...
RE: “Socioeconomic status and overweight/obesity in an adult Chinese population in Singapore” [bib_ref] Prevalence of obesity in Taiwan, Chu [/bib_ref] [bib_ref] Association between simple anthropometric indices and cardiovascular risk factors, Ho [/bib_ref] [bib_ref] Prevalence of obesity in Korea, Kim [/bib_ref] [b...
Hybrid approach to fabrication of hollow internally weighted mandibular denture: A case report Preservation of ridge dimensions is critical for denture success. For long the concept of an internally weighted denture, which suggested that gravity and the additional weight to the mandibular complete denture aids in pros...
Microbial Experimental Evolution – a proving ground for evolutionary theory and a tool for discovery Microbial experimental evolution uses controlled laboratory populations to study the mechanisms of evolution. The molecular analysis of evolved populations enables empirical tests that can confirm the predictions of ev...
Multifaceted roles of GRAS transcription factors in growth and stress responses in plants The GAI-RGA-and -SCR (GRAS) proteins regulate a myriad of biological functions in plants. The C-terminus of GRAS proteins is highly conserved, whereas the N-terminus is hypervariable. So far, GRAS proteins have been reported in m...
Bone Microarchitecture in Obese Postmenopausal Chinese Women: The Chinese Vertebral Osteoporosis Study (ChiVOS) Background: Obesity is associated with improved bone mass and microarchitecture in Caucasian individuals, but evidence in obese Asian individuals is lacking.Objective: To analyze the areal bone mineral densi...
Physiological correlates of cognitive load in laparoscopic surgery Laparoscopic surgery can be exhausting and frustrating, and the cognitive load experienced by surgeons may have a major impact on patient safety as well as healthcare economics. As cognitive load decreases with increasing proficiency, its robust assess...
A mild form of adenylosuccinate lyase deficiency in absence of typical brain MRI features diagnosed by whole exome sequencing Background: Adenylosuccinate lyase (ADSL) deficiency is a defect of purine metabolism affecting purinosome assembly and reducing metabolite fluxes through purine de novo synthesis and purine nu...
Risk and outcome in metastatic malignant melanoma patients receiving DTIC, cisplatin, BCNU and tamoxifen followed by immunotherapy with interleukin 2 and interferon alpha2a. Combined chemo-/immunotherapy has shown high objective response rates and a significant though small proportion of longterm complete responders i...
Drug Susceptibility Testing of 31 Antimicrobial Agents on Rapidly Growing Mycobacteria Isolates from China Objectives. Several species of rapidly growing mycobacteria (RGM) are now recognized as human pathogens. However, limited data on effective drug treatments against these organisms exists. Here, we describe the sp...
Haploidy in Tobacco Induced by PsASGR-BBML Transgenes via Parthenogenesis Background: Engineering apomixis in sexually reproducing plants has been long desired because of the potential to fix hybrid vigor. Validating the functionality of genes originated from apomictic species that contribute to apomixis upon transfer...
Finding multiple target optimal intervention in disease-related molecular network Drugs against multiple targets may overcome the many limitations of single targets and achieve a more effective and safer control of the disease. Numerous high-throughput experiments have been performed in this emerging field. However, s...
ASSOCIATION BETWEEN SMOKING, CRACK COCAINE ABUSE AND THE DISCONTINUATION OF COMBINATION ANTIRETROVIRAL THERAPY IN RECIFE, PERNAMBUCO, BRAZIL Despite the effectiveness of combination antiretroviral therapy in the treatment of people living with HIV/AIDS (PLWHA), nonadherence to medication has become a major threat to i...
Reliable resolution of ambiguous hepatitis C virus genotype 1 results with the Abbott HCV Genotype Plus RUO assay Accurate subtyping of hepatitis C virus genotype 1 (HCV-1) remains clinically and epidemiologically relevant. the Abbott HCV Genotype Plus RUO (GT Plus) assay, targeting the core region, was evaluated as a...
Lettuce (Lactuca sativa) productivity influenced by microbial inocula under nitrogen-limited conditions in aquaponics The demand for food will outpace productivity of conventional agriculture due to projected growth of the human population, concomitant with shrinkage of arable land, increasing scarcity of freshwater, ...
Primary Care Networks and Starfield’s 4Cs: A Case for Enhanced Chronic Disease Management # Introduction As the world ages at a rapid pace, the number of patients with chronic conditions is set to increase in tandem. Chronic diseases are commonly characterised by their requirement for long term follow-up with health...
Cannabidiol regulates apoptosis and autophagy in inflammation and cancer: A review Cannabidiol (CBD) is a terpenoid naturally found in plants. The purified compound is used in the treatment of mental disorders because of its antidepressive, anxiolytic, and antiepileptic effects. CBD can affect the regulation of severa...
The parasite Trichomonas vaginalis expresses thousands of pseudogenes and long non-coding RNAs independently from functional neighbouring genes Background: The human pathogen Trichomonas vaginalis is a parabasalian flagellate that is estimated to infect 3% of the world's population annually. With a 160 megabase genome...