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i thought i'd put this up since im still building it and wanted to share it, miniatures used in this are a tau fire warrior, a hordes winter argus, a warmachine vladimir tzepesci, the dark championand citadel dreadnought base. this is just for desplay and i am a little annoyed since no new tau model's have come out yet and i'v seen so many new ones come out for other armys, so that a little bit of motivation behind this, saw the none citadel models at the local store and went this might go well, so enough of me rambling onto the pics.
As an aside, I like the Tau. But save for six Tau Pathfinder Snipers I've never taken the plunge into WH40K. I just don't relate to the players at all. | 2019-04-23T20:01:34Z | http://gundamaustralia.com/forum/index.php?topic=3245.0 |
This seems obvious, all horchata should be vegan, right? It is a rice-based drink. But a lot of food bloggers (and even some taquerias) use real milk in their recipe. I’m not vegan, but that just seems… wrong. That’s okay, you’re about to make your own! This vegan horchata adds homemade almond milk to the mix, giving some depth and character to this summertime favorite.
There's a pretty simple rule to cooking: the simpler the recipe, the better the ingredients. That is, when you're using just a handful of ingredients, the quality of those ingredients really matters. So I suggest a high quality, organic, long-grain white rice for this recipe. You'll get more of that lovely rice flavor in the resulting drink.
Take the 1/2 cup of white rice and grind it up in the blender (or a spice grinder). Depending on the power of your blender, this can take a few minutes. To get an idea of how finely ground you want it, see the photo below, which has the original rice on the left and the ground on the right.
Now we are going to blanch our raw almonds. This is to aid in peeling them, which, by the way, is the most annoying task ever. Thank God I love horchata because I could write a whole blog post on 8,000 other things I'd rather be doing than peeling almonds. Simply add the 1 cup of raw almonds to a pot of boiling water and let them cook for just a minute. They're done when most of the almonds have risen to the surface. Strain the almonds and then rinse them under cold water.
On to the peeling! There are a few ways you can do this. You can simply pinch each almond, which will quickly squirt the nut from outside its skin. The problem with this method is it takes longer, and the escape velocity on those almonds is deadly. Seriously, it's a good thing I wear glasses! Why am I telling you this? Well, this method is kinda fun. Like, in a schoolboy kinda way. The quicker method is to take 3-5 almonds between your hands (drying your hand each time to create friction), and rub your hands really quickly. This will dislodge most skins, making them easy to peel away. Why did that sound dirty?
After peeling all the almonds (finally!), wrap them in a paper towel and let them dry out. Then add them to a frying pan and lightly toast them over a medium heat. The moment you see a few of them brown, you are good.
Add the 2 cinnamon sticks, the rice powder and the almonds to a large container and cover with 3 cups of hot water, stirring so that all of the rice is in contact with water. Let the mixture sit out at room temperature until cool. Then cover and let stand over night.
Add the remaining water and puree the mixture in small batches, getting it as smooth as you can. Strain out the bits and pieces using a tea strainer, mix in the 1/3 cup of sugar and chill. The horchata, not you.
Serve over ice. I use about 1/3 the sugar that most recipes call for and instead rim the glasses with sugar and ground cinnamon. I personally feel this adds a fun touch to the drink, gives it that same "sweetness" but with less actual sugar. | 2019-04-20T03:20:14Z | https://jerryjamesstone.com/recipe/vegan-horchata-almond-milk/ |
We had meetings with Waqas, Martin and Rozina on 17. and 18. October to explain potential topics for Master Thesis work at NILU and UNIK/UiO.
Sensor quality - how can we use other sensors to calibrate and get an idea on the reliability of sensor data. This topic might get a focus on "sensor calibration" or on "sensor network security", depending on the interest of the one who has to work with it. We discussed the novel concept of collaborative air quality assessment, where sensor data are seen not as the quality of each single sensor, but as the collaborative quality measures of the whole sensor network.
Privacy issues - how can me make sensor information publicly available, without breaching the privacy of the user. An idea here is to obfuscate the data, either in time, location or in quality. josef expects that one can work with policies and describe both data and application demands through semantic technologies.
Context- and content-awareness - which data shall be available is an issue for each sensor and sensor network. If the value of the information requires an urgent action, than several people might be informed. If data are used for a statistical analysis, then storage in a database might be the appropriate answer.
Social involvement in air quality sensing. This area addresses the involvement of users, and the methods to involve the users. One aspect is gamification, and the understanding is that users will get involved if the information acquired is either useful, convenient og just fun.
We agreed on keeping in contact to see which topics are of interest. | 2019-04-19T14:35:14Z | https://its-wiki.no/wiki/Citi-Sense-MOB_-_student_work |
“Then Aaron shall come into the tabernacle of meeting, shall take off the linen garments which he put on when he went into the Holy Place, and shall leave them there. And he shall wash his body with water in a holy place, put on his garments, come out and offer his burnt offering and the burnt offering of the people, and make atonement for himself and for the people. The fat of the sin offering he shall burn on the altar. And he who released the goat as the scapegoat shall wash his clothes and bathe his body in water, and afterward he may come into the camp. The bull for the sin offering and the goat for the sin offering, whose blood was brought in to make atonement in the Holy Place, shall be carried outside the camp. And they shall burn in the fire their skins, their flesh, and their offal. Then he who burns them shall wash his clothes and bathe his body in water, and afterward he may come into the camp (Leviticus 16.23–28).
That also included the work of the one who would take the goat into the wilderness and release it.
Notice that the high priest would leave the linen garments behind when he left the Holy of Holies and entered the Holy Place. He would then wash and put his other garments back on.
This work was so special that he could not wear the clothes that he wore through out the day, nor could he continue to wear them after he had finished this task. He wore those linen garments for only one reason. This would have helped to highlight just how special his work on the Day of Atonement was.
What do you think of the work that Israel’s high priest performed?
What do you think of the work of our High Priest, Jesus Christ?
This entry was posted in Email Devotionals, Leviticus and tagged Leviticus 16.23-28. Bookmark the permalink. | 2019-04-18T12:20:02Z | https://emaildevotionals.com/2019/02/13/the-priests-and-their-work-on-the-day-of-atonement-2/ |
Navata Accident Healthcare Services Private Limited is a Private Company incorporated at Registrar of Companies RoC-Hyderabad on 10/10/2011.
Navata Accident Healthcare Services Private Limited is majorly involved in Insurance and categorised as Company Limited by Shares and Indian Non-Government Company.
Corporate Identification Number (CIN) of Navata Accident Healthcare Services Private Limited is U66000AP2011PTC076893. | 2019-04-23T16:48:55Z | https://www.brainbuxa.com/company/navata-accident-healthcare-services-private-limited |
Indie Retro News: Fallout 1.5 Resurrection - A complete new story for Fallout 2 gets an English release!
Fallout 1.5 Resurrection - A complete new story for Fallout 2 gets an English release!
In 1998, Black Isle Studios with publishing rights by Interplay released the incredible RPG ' Fallout 2 ' for PC and MAC. It featured a large post nuclear game world, an extensive storyline, lots of characters, multiple weapon types, character stats and much more which made it one of the best RPG game's of our generation. And it is that game which has now had a full modification with a completely new story taking place in the Fallout universe. As the fan developers have said, "it's like new old-school Fallout, emphasising multiple approaches to quest solving and various styles of gameplay ". Welcome to Fallout 1.5 Resurrection, over 10 years of production is now in full English!
All you need in order to be able play Fallout 1.5: Resurrection is a full installation of Fallout 2, any version should work (no matter whether from Steam, GOG or CD/DVD). Resurrection already contains patch 1.02 for Fallout 2, as well as the High Resolution Patch for resolution options, and the engine tweak Sfall which introduces neat functional changes to Fallout 2. | 2019-04-26T07:39:48Z | http://www.indieretronews.com/2016/07/fallout-15-resurrection-complete-new.html |
inMotion are pleased to announce their collaboration with one of the largest privately-held real estate investment companies in the US, Ashely Capital.
While maintaining Ashley Capital’s existing corporate and brand colors, inMotion’s design team created a smart, modern and responsive website, and added a custom built property search engine that would enhance user experience and better communicate their stock of properties. This feature enables users to take a walk through Ashely Capital’s extensive portfolio of both fully leased and available properties, providing them with access to photos, plans, brochures, maps and even information on individual units within large industrial estates.
As part of the project we integrated a comprehensive content management system that allows Ashley Capital’s staff to make updates to content and property listings quickly and easily. | 2019-04-25T09:47:22Z | https://www.inmotionrealestate.com/news/inmotion-launches-new-website-for-ashley-capital/ |
According to Forrester Research, “Relevant knowledge at the right time is priceless in the enterprise“. This is particularly true in the highly competitive pharma industry where knowledge is hidden in a deluge of structured and unstructured data of all kinds, buried among publicly available sources such as trade databases, scientific publications, and patents, as well as internal repositories like R&D data, clinical trials, recorded patient interviews, and more! Sinequa and SciBite team up to provide a winning combination of Cognitive Search and powerful Life Sciences Semantics to help leading pharma organizations unlock the wealth of R&D data.
We look forward to seeing you on Thursday, September 20th – 10am ET / 4pm CEST. | 2019-04-19T01:35:25Z | https://www.sinequa.com/live-webcast-unlock-wealth-rd-data/ |
The Augusta Georgia Planning Commission is authorized under Title Eight of the Augusta, Georgia Code. The Planning Commission is an advisory board that holds hearings on certain development issues and formulates recommendations for consideration by the Augusta Commission.
Terms correspond with the term of the Commissioner elected for that district. For a current list of members, view Planning Commission Members.
A typical meeting agenda includes re-zoning petitions, subdivision plats and site plans, review of ongoing planning studies, and general administrative items. | 2019-04-26T14:48:59Z | https://www.augustaga.gov/297/Augusta-Planning-Commission |
Your information refers to the details about you (for example name, address, contact details, credit/debit card details, preferences, specific needs, interests etc) that you supply to us or is supplied to us. Your information is collected when you request information from us, apply for a job with us, contact us with regards to any specific enquiry, register with us, enter a competition or buy anything from us online. The amount of information we collect is controlled by you.
We operate CCTV at Pleasure Beach in certain areas and your image may be captured and processed and this is done to assist us and any Statutory Body in ensuring your reasonable safety and security during your visit. | 2019-04-24T04:44:26Z | https://www.southportpleasureland.com/cookies/ |
Jatiya Oikyafront chief Dr Kamal Hossain on Monday said the countrymen are now united to ensure their voting rights.
Dr Kamal, also the Gono Forum chief, made the remarks while addressing a programme arranged by Sammilito Peshajibi Parishad as the chief guest, reports UNB.
"People waged the Liberation War with a dream of becoming the country's owners and establishing their voting right. We're now untied to cast our votes," he said.
"Even after 47 years of the country's independence, we've to go to election through waging a movement. What can be more shameful than this?" questioned Dr Kamal.
"We're untied to use our voting rights... we've to safeguard the trust of martyrs. No autocrat will be allowed to stay there in power," he added.
The Oikyafront chief urged the voters to go to polling stations early in the morning on December 30 and stay there to check vote rigging and all other irregularities. "You all remain united so that no one can obstruct voters."
Recalling the glorious role of Bangladesh Police in the country's Liberation War, he called upon its members not to indulge in any unfair and unethical acts regarding the election.
Krishak Sramik Janata League president Abdul Kader Siddiqui, Nagorik Oikya convener Mahmudur Rahman Manna, BNP standing committee member Nazrul Islam Khan, Gono Forum's executive president Subrata Chowdhury, general secretary Mostafa Mohsin Montu, Gonoshasthya Kendra founder Dr Zafrullah Chowdhury and leaders of different professional bodies spoke at the programme. | 2019-04-24T18:35:59Z | https://thefinancialexpress.com.bd/national/politics/people-now-united-to-ensure-voting-rights-dr-kamal-1545664493 |
I'm happy you'll be returning in time for the playoffs. I'll try to be less annoying.
Avi! You've done some mad traveling the past year; Frau would be proud. Any chance you'll pass through New York on your return leg?
and you didn't get hernia? | 2019-04-24T22:51:59Z | http://greypen.blogspot.com/2007/03/air-up-there-in-udaipur.html |
Wireless sensor networks consist of small, inexpensive devices which interact with the environment, communicate with each other, and perform distributed computations in order to monitor spatio-temporal phenomena. These devices are ideally suited for a variety of applications including object tracking, environmental monitoring, and homeland security. At present, sensor network technologies do not provide off-the-shelf solutions to users who lack low-level network programming experience. Because of limited resources, ad hoc deployments, and volatile wireless communication links, the development of distributed applications require the combination of both application and system-level logic. Programming frameworks and middleware for traditional distributed computing are not suitable for many of these problems due to the resource constraints and interactions with the physical world.To address these challenges we have developed OASiS, a programming framework which provides abstractions for objectcentric, ambient-aware, service-oriented sensor network applications. OASiS uses a well-defined model of computation based on globally asynchronous locally synchronous dataflow, and is complemented by a user-friendly modeling environment. Applications are realized as graphs of modular services and executed in response to the detection of physical phenomena. We have also implemented a suite of middleware services that support OASiS to provide a layer of abstraction shielding the low-level system complexities. A tracking application is used to illustrate the features of OASiS. Our results demonstrate the feasibility and the benefits of a service-oriented programming framework for composing and deploying applications in resource constrained sensor networks. | 2019-04-21T20:21:40Z | http://www.isis.vanderbilt.edu/node/3464 |
“I think it’s always great to have something in your life other than your work and social life, so when I passed my accountancy qualifications I started looking for voluntary work. I found this opportunity on the do-it.org.uk website, and I applied to become a mentor, providing help and support to women who had just come over to the UK from other countries. I was always fascinated by gender issues, so I was really drawn to the work that Laamiga are doing.
However the organisation has been going through some really exciting changes, and I am now the treasurer of an expanding charity. It’s fantastic to be able to use what I know to help someone who might not have access to the information and support they need.
It’s also a really good way to learn something new. I’m using my skills but also learning how to run an organisation, build business plans…it reflects a skill set that I wouldn’t get in my day job. As far as my career development goes, it’s great to be able to be able to say I’m involved with an organisation that wants to grow, and I am helping it to do that. | 2019-04-22T05:12:30Z | https://volunteercentrecamden.org.uk/nabila-laamiga/?share=google-plus-1 |
New York, NY—Rebuild Penn Station hails New York Governor Andrew Cuomo for demanding a complete and urgent overhaul of the transportation depot in his 2018 State of the State address last week. The Governor made clear that the new Moynihan Station in the Farley Post Office is insufficient to fix the problems with Penn Station, which remains dangerous and ugly.
Appearing to refer the need to move Madison Square Garden, in his address the Governor also said that eminent domain could be used to build a new station.
· The original station’s intuitive design and clear sightlines will allow travelers to orient themselves and understand where exits are located.
· Widening the platforms and tripling the number of escalators to the tracks (as depicted here) will eliminate the current ingress and egress choke points.
· Removing Madison Square Garden’s support columns will eliminate obstacles to circulation and visibility that extend down to platform level.
· New exits will increase porosity to the side streets.
· New pedestrian ramps on Seventh Avenue will allow travelers to quickly leave the station en masse.
· The high ceilings in the concourse and main hall will allow the dispersal of smoke and poison gas.
You can find an FAQ on the proposal here.
For more information, please visit www.rebuildpennstation.org. To set up an interview, please contact vanessa@javelindc.com or 202-997-1289. | 2019-04-18T19:00:26Z | https://www.rebuildpennstation.org/governor-cuomo-calls-for-new-penn-station |
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A387 Gr12CL1 prime quality pressure vessel plate property . Henan BEBON Iron & Steel Co., Ltd was founded in 2000,with a good reputation in national steel market, we have established international business since 2000,after so many years operation,our clients spreads over all the world.
Meanwhile, these ASTM A387 Alloy Steel GR.11 CL.1 Coils have excellent resistance towards heat, stress-corrosion cracking and corrosive medium. Further, this ASTM A387 AS GR.11 CL.1 Sheets is also tested on various parameters of quality and is widely demanded by clients.The offered ASTM A387 AS GR.11 CL.1 Plates are manufactured utilizing best quality raw-material and the advanced technology.
Alloy Steel Plates Manufacturer. Marc Steel is a known supplier and trader of Alloy Steel Plates which are manufactured by making use of supreme-grade of steel and others. We are also engaged in manufacturing and supplying qualitative range of Alloy Steel Sheets.We have as well established ourselves as coveted organization, involved in providing Rural Electrification Service. | 2019-04-19T21:11:16Z | http://yugnirman.org/case/5.html |
Learn more about 11D through our Frequently Asked Questions. Want to know more? Contact us. | 2019-04-18T13:25:31Z | https://www.11dtyresealant.com/faq/ |
Preheat oven to 350°. Put cupcake liners in cupcake tray (this recipe makes 24 cupcakes). In large bowl with electric mixer, mix together on low cake mix, dark cocoa, cherry pie filling, eggs, and rum extract. Mix on medium for 3 minutes. Scoop batter into cupcake papers, evenly distributing batter for 24 cupcakes. Bake for 18-21 minutes, until center of cupcake is set. Cool completely before frosting.
Whip butter until light and creamy. Mix in half the powdered sugar. Mix in vanilla and milk. Add remaining powdered sugar. Whip well. Pipe onto cupcakes. Garnish with dark chocolate shavings, mini chocolate chips, chocolate jimmies, maraschino or bing cherries.
These cupcakes look amazing and Im excited to make them! Can you tell me if you make the cake mix according to direction first? Im worried this is not enough liquid, otherwise.
It does seem that way, but the pie filling and eggs together does make it work. It is a little thicker batter but the cupcakes come out very moist. Hope you like them, thanks for stopping but my site!
I made them before I read your reply and I added some water because it seemed to thick. My 17yr old son LOVES them and cant stop talking about them. He wants to share them with his GF, at school tomorrow. Next time Im gonna trust you and not ad the water….Thanks so much!
I made these for a potluck at my husband’s office, and they turned out great! Thanks for this awesome recipe!
I’m so glad! Thanks for visiting my site! Happy Baking!
I have made these twice, using different types of chocolate cake mix, and both turned out excellent! I really love the frosting recipe included too! Definitely my go-to fancy cupcake recipe! Thank you so much for writing it!
So glad the recipe works well for you! Happy baking!
Can these be made the night before, or will that ruin the frosting? Thank you for your time!
Making them the night before will work great. You can put them in the refrigerator if you would like, but covered at room temp they will be fine too. Thanks for visiting my site. Happy Baking!
I’m making these right now, but I am putting the cherry pie filling in the center instead of in the cake mix. The cake mix is very thick, will these still bake correctly? Thanks.
Sorry my response could not be instantaneous, as you were baking. The cherry pie filling is definitely an important part of the batter for the cupcakes.
I would really like to print the recipe without printing the whole 7 pages of the post. Is it possible and I’m just missing something?
I see what you mean. I use wordpress and the format that comes up when you hit print is messy! Sorry it is like that. What I would do is click to select the full recipe, copy and paste in a word document then print. Wish I could be more helpful. Happy Baking! | 2019-04-26T10:37:04Z | https://cookiescakespiesohmy.wordpress.com/2012/08/15/black-forest-cupcakes/ |
If you are looking for an office to rent at Guttahalli. This is a 16 X 16 sq ft office in Guttahalli. You have to only ay 3 months rent in advance. The rent ranges from Rs4000- 15000. This shop is located on the ground floor. The shop is north and east facing and is semi furnished. | 2019-04-24T04:18:50Z | http://www.kanosa.com/posts/details/office-space-for-rent-in-palace-guattahalli/2234446 |
The uncontrolled division of abnormal cells in the human body produces the disease we know as cancer. The distinguishing characteristic of this disease is the stealthy nature of its arrival and entrenchment in the human body. The patient is oblivious to its presence until it has taken root in the body. Regular screenings and total body checkups may help catch cancer in its early stages.
The process known as ‘Cancer Staging’ seeks to determine how far a cancer has spread when it is first diagnosed. This knowledge is crucial in helping the doctors decide the best course of treatment. It is also beneficial to the patient since they will be in an informed position and are able to judiciously consider the various treatment options available.
Typically these cancer stages are five, with the progression of zero to four denoting the cancer’s advance. Stage zero denotes that the cancer is “in place”, that is, confined to the place it originated from. This is the best time to tackle the cancer and the patient tends to respond well to treatment. Stage 1 (also known as Early Stage Cancer) simply means that the cancer has not grown deeply into nearby tissues and has not spread to other parts of the body. ‘Localised Cancer’ best describes the cancer at this stage.
Stages 2 and 3 indicate that the cancer has established itself into nearby tissues, and quite possibly into the lymph nodes, although aggressive metastasis has not taken place. We may label the cancer at this stage as ’Regional Spread’. Metastasis refers to the development of secondary malignant growths often far removed from the primary site of the Cancer in question.
Stage 4 Cancer, by logical progression, is cancer that has advanced and spread to other parts or organs of the human body. Cancer at this stage is also known as Metastatic Cancer or Advanced Cancer. The TNM (Tumour, Node, and Metastasis) system of Cancer Staging is widely used. Annotated with numbers (N3, for example) this system determines the size and possibility of the spread of the cancer, whether the cancer has spread to the lymph nodes, and also indicates the level of advancement (or otherwise) of the cancer in the body. N3 for instance would mean a lot of lymph nodes contain cancer cells. Blood Cancers by their very nature (non-tumour forming) are outside the scope of the TNM system. These cancers (Leukemia, Lymphoma and Myeloma) have their own grading systems.
All cancers at Stage 4 will display some common across-the-board symptoms and each cancer will also display symptoms peculiar to its family. Some of these universal indications of Stage 4 Cancer include extreme fatigue which is frequently accompanied by osteo-related (bone) pains. The other common sign at this advanced stage of Cancer is extreme weight loss.
It is not unusual for patients at this point to drop as much as a third or even half of their body weight. This will obviously hinge on the whether the patient had a lot of body mass to begin with. Other common signs that a patient with Stage 4 Cancer will invariably display include profuse perspiration, loss of appetite and inability to register thirst, extremely low body temperatures and frequent hallucinations.
As can be expected, Stage 4 Cancer requires a sustained regimen of specialised treatments.
We are always ready to help with any enquiries that you might have regarding the treatment of cancer. Contact us and a Patient Representative will help you make an informed choice among the various Integrative Treatments that we offer. | 2019-04-20T21:12:27Z | https://veritalife.com/stage-4-cancer-what-to-know/ |
INGELHEIM, Germany--(BUSINESS WIRE)-- Boehringer Ingelheim today announced that it has acquired all shares of ViraTherapeutics, a biopharmaceutical company specializing in the development of oncolytic viral therapies. ViraTherapeutics developed the lead candidate VSV-GP (Vesicular Stomatitis Virus (VSV) with modified glycoprotein (GP)), which is being investigated alone and in combination with other therapies. The total transaction value of EUR 210 million is based on an option and share purchase agreement signed between the companies in August 2016. | 2019-04-22T18:56:59Z | https://www.biospace.com/article/releases/boehringer-ingelheim-acquires-all-viratherapeutics-shares-to-develop-next-generation-viral-based-immuno-oncology-therapies/ |
Year 4 student Zara Findlay looks forward to her school’s twilight fete and the many raffle prizes on offer.
St Brendan’s Year 4 student Judd Pelly gives Year 2 student Tom Collins a push to roll into the week of their school fete.
An evening of entertainment, fun and food is in order for the Shepparton community.
St Brendan’s Primary School will host its biennial twilight fete on Friday night.
School principal Paula Stevenson said the event was set to be an enjoyable time for all.
‘‘There will be lots of food, with multicultural food stalls, lots of activities, jumping castles, games and lots to do,’’ she said.
She said students of all year levels would be involved on the night — assisting with various stalls and providing entertainment through song and dance.
Ms Stevenson said the school had received the support of many Shepparton businesses who donated goods for raffle prizes on the night.
She said they also had many student parents who had got on board, assisting with preparation and stalls on the night.
‘‘It’s just a great night for all the community to come along and it looks like the weather’s going to be good, so we’re hoping for a really good turnout,’’ she said.
The fete will be at St Brendan’s Primary School on Friday, from 5pm to 8pm. | 2019-04-19T13:18:48Z | http://education.sheppnews.com.au/@education/2018/11/12/318882/entertainment-familyevents1111-st-brendans-primary-school-prepare-for-twilight-fete |
SHRM Hawaii is a non-profit corporation representing more than 900 human resource professionals throughout the State of Hawaii.
We are also an Affiliate of the Society for Human Resource Management (SHRM), the world’s largest association devoted to human resource management. Representing more than 210,000 individual members, the Society's mission is to serve the needs of HR professionals by providing the most essential and comprehensive resources available. As an influential voice, the Society's mission is also to advance the human resource profession to ensure that HR is recognized as an essential partner in developing and executing organizational strategy. Founded in 1948, SHRM currently has more than 550 affiliated chapters within the United States and members in more than 100 countries. Visit SHRM Online at www.shrm.org. | 2019-04-19T22:19:32Z | https://www.shrmhawaii.org/page/A2 |
Partnering with NatureWorks, LLC., in the release of their new Ingeo PLA formulation offering high heat and impact resistance, 3D-Fuel introduces Advanced PLA+ (APLA+).
APLA+ was created specifically for 3D printing, where most filament materials are formulated first for other industries then adapted for FDM filaments. Its predecessor, APLA (Advanced PLA), was the first ever material formulated for 3D printers.
Specifically, APLA+ was designed with the high impact strength needed in industrial applications to meet the growing demand by companies for a material with the properties of ABS, but the printability of PLA. Where annealed APLA displays impact strength levels at 1.7 times that of standard PLA, the new APLA+ boasts 4.3 times that of PLA. Even before post-processing, APLA+ exhibits significantly higher impact strength than ABS.
Both APLA formulations are annealing PLAs with high heat resistance. A post-print annealing process will crystallize the materials and provide additional heat and impact properties.
All of 3D-Fuel’s PLA materials (Ingeo™ PLA, APLA, and APLA+) are all NatureWorks’ Ingeo™ certified, meaning the filament has passed a defined set of tests to assure the quality of the product.
Annealing directions and printing tips may be found here.
APLA+ is available now at 3DFuel.com. Currently only in Natural, other colors will be released shortly.
NatureWorks LLC is a company dedicated to meeting the world’s needs today without compromising the earth’s ability to meet the needs of tomorrow. Today, NatureWorks is a world leading biopolymers supplier and innovator with its Ingeo portfolio of naturally advanced materials made from renewable, abundant feedstocks with performance and economics that compete with oil-based intermediates, plastics, and fibers, and provide brand owners new cradle-to-cradle options after the use of their products. NatureWorks is jointly owned by Thailand’s largest chemical producer, PTT Global Chemical, and Cargill, which provides food, agriculture, financial and industrial products and services to the world. For general information on NatureWorks and Ingeo, visit www.natureworksllc.com. | 2019-04-24T15:52:10Z | https://ww2.3dfuel.com/3d-fuel-introduces-new-apla-offering-heat-impact-resistance-rivaling-abs/ |
297 WEST GREAT WESTERN RD.
Do you need more storage space on Cape Cod? At All Cape Self Storage in Dennis, MA, we can safely store a wide range of items for you. Our secured storage facilities are great for renters, builders and contractors, home and condo owners, distributors, salespeople...if you have a storage need, we have the secure space.
Our facilities are available for a wide range of storage needs including residential and commercial storage, inventory for your small business or temporary storage while your house is being built or remodeled.
Moving and don't want to travel all the way to Hyannis for things you need? All Cape Self Storage is your source for moving supplies: we stock a complete line of moving and packing supplies including boxes, tape, moving pads and bubble wrap. We are also an authorized U-Haul rental location.
We have everything from boxes to packing materials, which means we have you covered.
Our secured facility allows you easy access to your self storage unit. | 2019-04-20T16:39:15Z | https://www.allcapeselfstorage.com/ |
The official Twitter account of the Girlfriend (Beta) [Girlfriend (Kari)] anime has been revealing new cast members every day for its upcoming Fall/Autumn 2014 adaptation of Cyber Agent’s popular mobile game. A total of 22 stellar cast members have have been revealed so far.
Here is a simplified chart of all the confirmed cast and characters for the GirlFriend (Beta) anime. Click on it for the full resolution.
GirlFriend (Beta) [Girlfriend (Kari)] is a free to play, mobile online battle card game developed by Cyber Agent for their Ameba social network. The game also featured dating sim mechanics, where you can date any of the 90 characters, and it even spawned a spin-off game titled Boyfriend (Beta). GirlFriend (Beta) released in 2012 on Android and IOS devices in Japan and to date has over 5.3 million users, where no news on localisation has been made so far.
GirlFriend (Beta) will be premiering from October 12th on TV Tokyo at 1:35 am during the Fall/Autumn 2014 anime season. Additional information about the series will release in the upcoming weeks. | 2019-04-21T10:03:41Z | http://www.otakutale.com/2014/girlfriend-beta-full-anime-cast-revealed-promotional-video/ |
Party time! Celebrate your 4th Birthday with our 2019 edition Number Tees, filled with festive balloon print. Available in gold and silver foil print on white cotton tee.
Available in 4Y size only. 95% cotton, 5% spandex. | 2019-04-21T16:49:59Z | https://lepetitsociety.com/number-4-tee-in-white-gold-2019-edition |
Check out the retreats below and either book here or send Dan an email dan@snowballchalet.com if you would like to book with a human or would like more information.
The ski season in Japan is such a great time to travel to the Nagano Region of Japan. You will be doing daily yoga and if want to ski or snowboard you will be in heaven. There is also gorgeous snow shoe trails through the white birch forests of the region. For the more adventurous you can also do back country tours with the local mountain guides which get's you into the dramatic wilderness of the mountains.
The Cherry Blossom season in Japan is a stunningly beautiful time to travel to Japan. As well as daily yoga the Cherry Blossom Yoga Retreat includes a day tour to visit the Cherry Blossoms in the Nagano or Niigata region of Japan. | 2019-04-22T00:26:37Z | https://japanzenretreats.com/retreats |
Following acclaimed runs at the Traverse Theatre in Edinburgh and Salford's Lowry, Henry Filloux-Bennett’s adaptation of Nigel Slater’s award-winning autobiography Toast makes its West End debut at The Other Palace in April.
Directed by Jonnie Riordan, Toast charts a path through Slater's formative years, vividly recreating daily life in suburban England in the 1960 through the food, tastes and smells he grew up with. From making the perfect sherry trifle, recalling his mother’s surprisingly good rice pudding, his father’s bold foray into spaghetti, the dreaded Boxing Day stew and waging war over cakes, this is an incredibly moving and evocative coming of age tale of love and loss.
The Other Palace is fully accessible, with wheelchair access available to auditoriums and the bar. Wheelchair seats and step-free access is back row only in the Theatre.
There is a Sennheiser infrared hearing system in operation in the theatre with two types of hearing devices available to customers: headphones that amplify the sound or a necklace loop that can work in conjunction with a hearing aid.
To buy theatre tickets for Toast at The Other Palace Theatre, London, please use the availability search at the top of the page or click the buy tickets button. We aim to offer the cheapest prices and the highest level of customer service.
Begin by selecting the date you wish to attend a performance of Toast and select the desired number of tickets. We'll then search our database for availability and you'll be presented with a list of available seating types (Grand Circle, Stalls, Balcony etc). You'll be shown the price per person for each seating type and you'll be able to select exactly where you want to sit.
In many instances you'll find Toast tickets available at substantial discounts on the normal ticket price, giving you great value for money. So even if you're on a tight budget, there should be a cheap deal available which suits.
A night out to see Toast wouldn't be complete without a meal in a top class restaurant. Make your choice from a selection of restaurants conveniently situated close to The Other Palace Theatre, London and opt to have a meal before or after the show. Our Toast and meal packages offer a variety of cuisines and budgets to suit all.
Combine tickets to Toast with a stay in a top hotel. | 2019-04-21T02:39:25Z | https://www.1st4londontheatre.co.uk/tickets/toast |
We were thrilled when Los Angeles recognized the State of Emergency of Skid Row and prioritized the issue of homelessness. It is absolutely an epidemic right now. The time is past due to allocate resources to the problem.
Unfortunately, the money just hasn’t shown up. I know it makes us feel great that we’re talking about a plan, or proposing a budget, but that doesn’t help the people dying on the street tonight. This emergency was declared six months ago and we’re still talking about what we’re going to do next year or over the next five years.
We’ve gone from 44,000 people experiencing homelessness to 47,000 people, an increase of almost 6%. Of that 3,000 more people, 40% are single women. Now, more than ever, we need to find a place to shelter these vulnerable people, yet more and more shelters are closing their doors. We lost over 2,000 shelter and transitional beds county-wide.
Since last year, the numbers on the streets have increased and over 40% of that growth is single women. We are going backwards.
At Union Rescue Mission, women and children outnumber men for the first time ever and we’re sheltering over 1,000 people each night. Since 2013, there has been a 55% increase in women experiencing homelessness in Los Angeles. We need more options now so women are not stuck on mean streets of Skid Row or anywhere in our city. My heart won’t rest as long as women and children are on the streets. We, Union Rescue Mission, will not rest as long as women and children are on the streets. With your help, while others talk we will continue to step up.
Please consider giving a gift during our Matching Gift Challenge and make an impact on the lives of those experiencing homelessness that have come to Union Rescue Mission. Any gift you give will be matched 100% by our anonymous donors.
This entry was posted in Rev Andy's Blog and tagged Downtown, Downtown LA, downtown Los Angeles, homelessness, LAHSA, Los Angeles, Skid Row, union rescue mission, URM, women and children. Bookmark the permalink.
Someone from our volunteer department should be reaching out to you soon.
The VACANT SALVATION ARMY BUILDING WILL HOUSE AND PROVIDE JOBS FOR THE HOMELESS WOMEN AND CHILDREN. ….SIMPLY TAKE ACTION PRIORITIZE WHAT MATTERS.
I would like to volunteer my time , on Monday or Thursday. Please let me know if theirs anything available.
I have lived in Downtown LA for 10 years and I’ve noticed an uptick in homelessness. I walk everyday to work and to home and I am confronted in a very visceral way by all forms of homeless people-sleeping, panhandling, screaming/making a scene, and a very few who try to engage in an aggressive manner. I’ve read your advice on providing them with resources and a handout as a last resort. What are their resources? Where to sleep? Eat? Get medical attention? My little girl growing up in the city also wants to know if we should give them snacks and our money. We are also Christians. But just me and my little girl I’m too scared to approach many of them. Please advise. | 2019-04-25T06:07:07Z | https://urm.org/2016/05/skid-row-state-of-emergency/ |
Clares Kitchen - Caterer providing outside catering services for business events, parties and special occasions. View menu examples and prices.
Connoisseur Dry Cleaners - Family firm dating back to 1955 with details of their collection and delivery services of all dry cleaning needs.
Darcars - Vehicle servicing, MOT and diagnostic centre highlighting the services offered with online booking and details of cars for sale. | 2019-04-20T00:14:16Z | https://uk.ezilon.com/uk/regional/england/london/boroughs/camden/business_and_economy/index.shtml |
[stamp] Photo-Art Commercial Studios, 420 S. W. Washington St. Portland 4, Oregon, Phone BR 5-11; Important. Record this number 124521-2 to avoid delay in securing duplicates use number above to identify this photograph.
Transcription [stamp] Photo-Art Commercial Studios, 420 S. W. Washington St. Portland 4, Oregon, Phone BR 5-11; Important. Record this number 124521-2 to avoid delay in securing duplicates use number above to identify this photograph. | 2019-04-19T08:54:26Z | http://history.ci.oswego.or.us/cdm/ref/collection/p17202coll1/id/748/ |
Moscow — Russian oil companies are willing to continue cooperation on output with other countries within the OPEC/non-OPEC production agreement, but have yet to discuss an output cut or concrete volumes, officials said following a meeting with energy minister Alexander Novak Thursday.
"We discussed possible cooperation with other countries and agreed that cooperation is necessary," Ravil Maganov, first executive vice president of Lukoil, told reporters after the meeting.
When asked whether Lukoil would be willing to cut output, he said: "We have not discussed that, but I am not ruling it out."
He added that the discussion Thursday did not include concrete output figures.
Russneft President Evgeny Tolochek said that the company would be willing to cut if it is beneficial to the market, but said companies did not discuss a cut during the meeting.
Other Russian energy companies represented at the meeting included Rosneft, Gazprom Neft, Tatneft, Transneft, Novatek and Surgutneftegaz. Novak traditionally discusses Russia's position with companies ahead of meetings of the OPEC/non-OPEC deal JMMC, of which he is a co-chair.
The next JMMC meeting will take place on Sunday, when the group is expected to discuss the current market situation and possible scenarios and actions for 2019. | 2019-04-21T17:08:12Z | https://www.spglobal.com/platts/en/market-insights/latest-news/oil/110818-russian-oil-companies-ready-to-continue-cooperation-within-opec |
Bamboo is very good in bearing water, snowfall and constant sunshine in open areas. This is the reason why most people prefer bamboo over other types of fencing woods. Unlike most of the other fences, bamboo fencing is tricky. No matter how experienced you are in fence installing, you can't deal with this material without professional help. If you want to install bamboo fencing around your house, you need to call a qualified contractor. In Anula there are a number of companies that provide bamboo fencing services. | 2019-04-23T20:32:49Z | https://fencinganula.fencing-kwikfynd.com.au/product/bamboo-fencing |
the rhythm of the heart [the seasons] 心臓の律動的な動き[四季の周期的変動].
【音楽】 調子 (cf. melody 3，→harmony 2).
音楽： reverie rh rhapsody rhythm rhythm and blues rhythm section rit.
First coined 1557, from Latin rhythmus, from Ancient Greek ῥυθμός (rhuthmós, “any measured flow または movement, symmetry, rhythm”), from ῥέω (rhéō, “I flow, run, stream, gush”).
The variation of strong and weak elements (such as duration, accent) of sounds, notably in speech or music, over time; a beat or meter.
A specifically defined pattern of such variation.
The tempo or speed of a beat, song or repetitive event.
We walked with a quick, even rhythm.
The musical instruments which provide rhythm (mainly; not または less melody) in a musical ensemble.
A regular quantitative change in a variable (notably natural) process.
Controlled repetition of a phrase, incident or other element as a stylistic figure in literature and other narrative arts; the effect it creates. | 2019-04-25T12:09:34Z | https://ejje.weblio.jp/content/rhythm |
The italian economy: heaven or hell ?
The italian economy: what next?
Is the economic cycle still alive? | 2019-04-25T16:24:23Z | http://www.mariobaldassarri.net/site/books-by-palgrave-macmilan-editor/?lang=en |
A real unique thing of the world! A 16th century Ottoman Turkish bath fed by natural thermal springs!
Rudas Bath was built by the Ottoman Turks in the 16th century at the place that later got the name: BUDAPEST.
A unique thing of the world! A 16th century Ottoman Turkish bath fed by natural thermal springs! While Turkish baths in Istanbul or other places in Turkey are in short of water, so they have to carry water to the bath and generate steam of it, Budapest has a lot of hot springs; so beside enjoying steam and heat, you may even soak into the pools of various temperature!
Rockhoppers will introduce you to the way how to use the bath, and charge your batteries for a week; and if you have a chance to return, you can prolong the effect.
The hottest pool in the Rudas is radioactive, but don’t worry, it is well below the harmful level, however, it has rejuvenescent effect! Obviously, you will have to come to the bath several times in order to feel ten or twenty years younger. However, even if you do it once, the result will be noticeable.
We shall be there with you, and introduce you the know-how of the bath. Some of us are addicts there, and go there for more than 30 years now.
So don’t hesitate, try this miracle of Budapest with us!
Exceprt from Yol – Sufi. Kudsi Ergüner, nay. | 2019-04-24T09:54:36Z | http://rockhoppers.eu/the_specials/mystery-turkish-bath/ |
It didn't seem that long ago that we hunkered down for the "once-in-500-years" storm that was Hurricane Irene. Although the storm's presence wasn't strongly felt in Manhattan, damage outside of the city was widespread. A month later we endured a "once-in-500-years" Halloween blizzard that gave us a dusting, but dumped feet of snow upstate. After these storms, we're very prepared for Hurricane Sandy. The entire city is shut down and again its eerily quiet. There are only 4 businesses open in our neighborhood: one Korean market and three liquor stores (the liquor stores are packed).
We have plenty of food, water and wine, and the iPads are fully charged. Now we wait. | 2019-04-23T00:21:45Z | https://kriskoeller.com/blog/2012/10/29-waiting-for-hurricane-sandy.htm |
Fiona Cooper is a consultant on trade policy and government relations, drawing on around 30 years of experience in the private and public sectors. She is Associate Director of the New Zealand International Business Forum. She provides the Secretariat for the Australia – New Zealand Leadership Forum, in conjunction with Business New Zealand. She has served as Lead Staffer for APEC Business Advisory Council members in New Zealand and for ABAC’s Regional Economic Integration Working Group. In October 2014, as Principal of Cooper Clarke Consulting Ltd, Fiona was appointed Executive Director of the NZUS Council, having previously served on its Executive Committee and Advisory Board.
Fiona was formerly Head of Corporate Relations at Bank of New Zealand and before that held a range of trade policy leadership roles with Fonterra Cooperative Group, NZ Dairy Board and Dairy Companies Association of New Zealand. Before joining the private sector Fiona served in the NZ Ministry of Foreign Affairs and Trade including a trade policy posting to Washington DC, two secondments to Parliament and a year on exchange in the Australian Department of Foreign Affairs and Trade.
Before joining the private sector Fiona served for nine years in the New Zealand Ministry of Foreign Affairs and Trade including a trade policy posting to Washington DC. While in Washington she represented New Zealand at the FAO Consultative Subcommittee on Surplus Disposals and was elected to chair that body in 1995. During her time in the Ministry Fiona was seconded to Parliament as Private Secretary (Trade) to the Minister of Trade Negotiations, and served as junior foreign policy advisor to the Prime Minister. She spent a year on exchange in the Australian Department of Foreign Affairs and Trade in Canberra in 1989.
She has a BA (Hons) in Political Science from the University of Canterbury and has also studied leadership with INSEAD, the US Center for Creative Leadership and the Institute of Strategic Leadership in New Zealand. | 2019-04-19T08:28:19Z | http://jacobi.co.nz/people/fiona-cooper-clarke/ |
Century 21 Olympian uses search engines and high end technology. While all Houston real estate companies use Houston Association of Realtors (HAR), we also use many other systems including Zillow, Truxillo, and Home Builders. We also have residential and commercial clients who input their information directly into our search engines when they are looking to buy property. Actually, most people look for their new home online before actually buying or contacting any realtor, so our technology actually captures about 72% of our buyers.
Century 21 Olympian has a free moving truck that is available for use by agents, and their buyers and sellers. There is no cost for the use of the truck, you only need to put in gas.
Well before you’re ready to plant that “For Sale” sign in your front yard, there is work to be done to prepare your home for sale. Remember how keen your eye was to every small detail and defect in the houses you saw as a buyer? Now that door to your bedroom that never quite closed properly or that leaky faucet that you never got around to fixing will be seen by a potential buyer with that same keen eye. Start making the obvious repairs today – even if you don’t plan to sell until a year from now. These repairs can cost money and take time.
If you plan on doing some improvements before the sale, the best place to start is where the buyers start: at your curb. Potential buyers base a large part of their decision on a property’s “curb appeal,” so make yours say something positive. That means a tidy front yard, a house with well-painted trim, a tidy driveway and a clear, welcoming entryway. Inside, the biggest return on your investment continues to be improvements to the kitchen, followed closely by improvements to the master bedroom. If you’re making these improvements shortly before selling the house, consider painting and decorating the rooms in neutral colors, the most appealing choice to the greatest number of potential buyers.
For example, marketing your property in more innovative ways, such as on an Internet site like this one, may broaden the pool of potential buyers. If you can, waiting for a good time to sell your home – spring or fall, the most popularly home buying times – also may help it sell faster except in this Seller’s market, anytime is a good time. And pricing the home properly can make a huge difference in whether a house is snapped up within the first several weeks of listing or sits on the market for more than a year.
Selling prices: What are other properties like yours selling for?
You may even want to include a few lines about benefits of moving to this property, such as good schools, convenience to mass transit and other desirable community features. You’ll work with me to discuss what the features and benefits of your property are.
Now that you’ve decided with me on the market price and how you will market your home now there’s little time left to get your house ready for visitors. | 2019-04-26T16:01:38Z | https://century21olympian.com/selling-your-property/ |
Witzend ReplaceInFiles is an add-in that provides Visual C++ with the ability to search and replace in all project source files.
MMultiBandWaveShaper is a strong multiband wave-shaping VST host plug-in. MMultiBandWaveShaper is a strong multiband wave-shaping plug-in that literally lets you draw your own signal graph.
Art-Copy turns your color scanner into a color copier or a fax machine. Art-Copy has an interface that works like a typical copying machine.
This software will help you to manage your lists of email addresses. | 2019-04-24T04:06:20Z | https://www.files32.com/downloads.asp?software=esata+drivers+for+mac |
Home » Events » Dress for Success SWFL Presents Health & Wellness EXPO & Fashion Show!
Dress for Success SWFL Presents Health & Wellness EXPO & Fashion Show!
Are you looking for something to do this Saturday? Dress for Success SWFL presents the Awesome Health & Wellness EXPO & Fashion Show this Saturday, August 24th from 10 a.m. to 1 p.m. at the Edison Mall – Dillard’s Court. Sponsored by Aetna, Edison Mall, Glamour Shots, Image Matters, Mary Kay, and Radiology Regional Center, this will be an event you will not want to miss!
The event is FREE to attend and features exhibitors and seminars on healthy living, wellness, fashion, and beauty. The fashion show will feature the latest trends, courtesy of Macy’s.Samples, coupons, and goody bags are available while supplies last.
Sponsors will also be offering exciting raffle prizes, selling products, and giving health, beauty, and makeup tips!
When you’re there, be sure to check out the Mobile Mammo Coach from Radiology Regional Center. Appointments are recommended, but walk-ins are welcome. Medicare and most insurances are accepted. Don’t have insurance? Radiology Regional Center will be offering discounts on mammograms for those without insurance. To make an appointment, call (239) 936-4068.
Get together with your friends and stop by this exciting event tomorrow in support of Dress for Success SWFL! | 2019-04-19T15:01:08Z | https://www.conricpr.com/in-the-news/news/dress-for-success-swfl-health-wellness-expo-2/ |
Discover and research the 2 nursing schools in Bakersfield, CA. Get started by entering your location and level of education to find schools which fit your needs.
There are 2 Nursing Schools in Bakersfield, CA. | 2019-04-20T02:12:46Z | https://www.noodle.com/nursing/bakersfield-ca_location |
32 - 7740 Abercrombie Drive, Richmond - SOLD | Yi-Jung Alice Wu - Jovi Realty Inc.
The Meadows. 3 bed, 2 bath, 2 storey townhouse in the centre of Richmond. Functional floor plan for the family with updated paint. Countertops in all bathrooms and kitchen. New carpet and main floor bathroom. This unit is across from visitor parking, convenient for your guests. Well maintained complex. Book your viewing now. | 2019-04-21T22:56:23Z | http://www.alicewubcproperty.com/property_details-3-108732.html |
Book your flights from Norfolk to Atlanta and save big on airfares. Infuse fun into your life by planning a vacation in Atlanta which is the capital of US state of Georgia. From enticing outdoor adventures, thriving arts scene to ancient museums, Atlanta is one destination that offers something for everyone. Enjoy Broadway musicals at the famous Fox Theatre and explore rare marine life at Georgia Aquarium which is decorated with more than eight million gallons of water. Adventure enthusiasts should head to Centennial Olympic Park which boasts of spectacular ice skating rinks.
Some of the premier airlines that operate flights from Norfolk to Atlanta are United Airlines, American Airlines and US Airways. Take advantage of exclusive deals on flights to Atlanta and save more to splurge on a vacation. The flight from Norfolk to Atlanta takes about two hours and thirty minutes to cover a distance of about 516 miles excluding the layover time. So get set for a memorable vacation in the land of Atlanta.
How many weekly flights are there are between ORF to ATL? There are 4 weekly flights between ORF and ATL. | 2019-04-23T14:33:24Z | https://www.onetravel.com/flights/from-norfolk-to-atlanta-orf-to-atl |
How much is apibox.xyz worth?
Error: No appropriate Whois server found for apibox.xyz domain!
Note: we are not promoting, linking to, or affiliated with apibox.xyz in any way. We are just collecting apibox.xyz seo statistics and Alexa rank data for historical purposes and We are just displaying apibox.xyz publicly available data & statistics for analysis purposes. | 2019-04-20T06:10:48Z | http://webrankdirectory.org/siteinfo/apibox.xyz |
Ms. Broder’s recent transactions include representing Oaktree Capital Group in its pending $4.7 billion partial sale to Brookfield Asset Management; BDT Capital Partners in its investment in the $7.5 billion acquisition of Panera Bread Company with majority investor Joh. A. Benckiser (JAB); and The Yucaipa Companies as shareholder in the $725 million IPO of Americold Realty Trust and subsequent $1.4 billion underwritten public offerings of its remaining Americold shares.
The Deal notes that Ms. Broder began her career “at the pinnacle of corporate law” as a clerk for the Honorable Leo E. Strine Jr., then chancellor of the Delaware Court of Chancery and currently the chief justice of the Delaware Supreme Court. Ms. Broder’s career has since “lived up to the promise that start suggests,” wrote The Deal.
Elected partner in January 2019, Ms. Broder focuses her practice on mergers and acquisitions, general company representation and securities law compliance. She represents public and private clients across multiple industries in a variety of transactions, including acquisitions and dispositions, investments and other complex corporate transactions. Ms. Broder also regularly advises boards, founders and key stakeholders on corporate governance and other strategic matters. | 2019-04-18T15:14:57Z | https://www.mto.com/news/headlines/2019/the-deal-names-jennifer-broder-m-a-rising-star |
See also, archival textbooks and e-books.
InterPARES 2 Luciana Duranti and Randy Preston eds. International Research on Permanent Authentic Records in Electronic Systems (InterPARES) 2: Interactive, Dynamic and Experiential Records. Rome: ANAI, 2008.
Korean Online Union Catalogs (KERIS) - Union catalog of 300 university libraries in Korea.
This page was last modified on 9 February 2011, at 17:43.
This page has been accessed 57,864 times. | 2019-04-22T02:50:49Z | http://archivopedia.com/wiki/index.php?title=Technical_handbooks_and_guides |
CATALYTIC ACTIVITY: ATP = 3',5'-cyclic AMP + diphosphate.ENZYME REGULATION: The regulatory domain is involved in the regulation of cyclase activity by the carbon source.
Below are the list of possible Adenylate cyclase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the reer's specifications.
Also known as Adenylate cyclase (ATP pyrophosphate-lyase) (Adenylyl cyclase).
Also known as Adenylate cyclase 1 (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1).
Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.
Also known as Adenylate cyclase 2 (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).
Also known as Adenylate cyclase CyaB (ATP pyrophosphate-lyase) (Adenylyl cyclase).
In vitro, CyaB catalyzes the biosynthesis of cyclic AMP (cAMP) from ATP. It seems that under the physiological conditions CyaB has no function in cAMP processes. In vitro, it is also able to hydrolyze substrates such as thiamine triphosphate (ThTP) and inorganic triphosphate (PPPi) at a low rate. It has a slight preference for ThTP over ATP and PPPi in the presence of manganese ions. This PPPase activity is probably not of physiological importance.
Also known as Adenylate cyclase type 1 (ATP pyrophosphate-lyase 1) (Adenylate cyclase type I) (Adenylyl cyclase 1) (AC1) (Ca(2+)/calmodulin-activated adenylyl cyclase).
ADCY1: a calmodulin-sensitive adenylyl cyclase expressed in brain. The mouse protein is involved in pattern formation of the brain. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.
Also known as Adenylate cyclase type 10 (AH-related protein) (Adenylate cyclase homolog) (Germ cell soluble adenylyl cyclase) (hsAC) (sAC) (Testicular soluble adenylyl cyclase).
SAC: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. Genetic variations in ADCY10 are a cause of susceptibility to hypercalciuria absorptive type 2 (HCA2). Absorptive hypercalciuria is a common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 3 isoforms of the human protein are produced by alternative splicing.
Also known as Adenylate cyclase type 2 (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2).
ADCY2: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Also known as Adenylate cyclase type 3 (ATP pyrophosphate-lyase 3) (Adenylate cyclase type III) (AC-III) (Adenylate cyclase, olfactive type) (Adenylyl cyclase 3) (AC3).
ADCY3: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Involved in odorant detection (possibly) via modulation of intracellular cAMP concentration.
Also known as Adenylate cyclase type 4 (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4).
Also known as Adenylate cyclase type 5 (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5).
ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.
Also known as Adenylate cyclase type 6 (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (ACVI) (Adenylyl cyclase 6) (AC6) (Ca(2+)-inhibitable adenylyl cyclase).
ADCY6: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.
Also known as Adenylate cyclase type 7 (ATP pyrophosphate-lyase 7) (Adenylate cyclase type VII) (Adenylyl cyclase 7).
Also known as Adenylate cyclase type 8 (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (AC8) (Ca(2+)/calmodulin-activated adenylyl cyclase).
ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Also known as Adenylate cyclase type 9 (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (ACIX) (Adenylyl cyclase 9) (AC9).
Also known as Adenylate cyclase, aggregation specific (ATP pyrophosphate-lyase) (Adenylyl cyclase).
Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure.
Also known as Adenylate cyclase, germination specific (ATP pyrophosphate-lyase) (Adenylyl cyclase).
Has a large extracellular domain which may be involved in the recognition of an extracellular signal present during germination, leading to activation or inhibition of cAMP synthesis by the cytoplasmic domain.
Also known as Adenylate cyclase, terminal-differentiation specific (ACB) (ATP pyrophosphate-lyase) (Adenylyl cyclase).
Through the production of cAMP, activates cAMP-dependent protein kinases (PKAs), triggering terminal differential and the production of spores. | 2019-04-18T12:25:16Z | https://www.mybiosource.com/proteins-family/adenylate-cyclase |
You can convert PRN files to RTF format making them accessible via almost all text editors used today. RTF is a universal document format bigger in size than DOC or PDF, but it has one big advantage - universal compatibility. You can convert PRN to RTF via command line in Total PDF ConverterX.
You will get all RTF files from the Documents folder converted into RTF and stored in the Converted folder. The entire process is executed in a background mode, you will see no popups or progress bar on your screen. If you need to integrate the program into GUI, use ActiveX. This technology is supported by this server PRN converter and helps to integrate it into other apps or graphic shells.
You can also use Total PDF ConverterX for turning PRN files to PDF, Doc, JPEG, PNG and other formats. There is a lot of file types supported. With the help of this program poorly supported and non-usable PRN files can become text documents or images that are easy to handle and edit. Try the program in a trial version and make sure it features the options you need! | 2019-04-25T17:57:06Z | https://amp.coolutils.com/PRN-to-RTF-CommandLine |
Henderson County graduate DeAsia Outlaw is one of five members of the first full recruiting class for first-year Murray State coach Rechelle Turner.
MURRAY, Ky. – Henderson County graduate DeAsia Outlaw is one of five members of the first full recruiting class for first-year Murray State coach Rechelle Turner.
Outlaw, who has spent the last two years at Wabash Valley College in Mount Carmel, Illinois, averaged 12.3 points and 7 rebounds last season in helping the Lady Warriors to a 31-2 record that included conference, region and district championships.
Outlaw, whose 57 percent field-goal shooting was in the top 20 in the country, was selected to attend the NJCAA Top-40 All-Star Game.
After sitting out her first year at Wabash Valley because of injury, Outlaw is preparing for her second season at the Illinois junior college. The 5-foot-11 guard/forward will have two years of eligibility remaining at Murray State beginning with the 2018-19 season.
“DeAsia is a proven winner at every level she has played," Turner said. “Her energy is infectious and has a 'whatever it takes' attitude. She will go a long way in building our championship culture. We are excited about DeAsia and the game experience she will bring to our team."
A 2015 graduate of Henderson County, Outlaw helped the Lady Colonels win three straight Second Region championships and finished her career with 1,075 points. She was the Second Region Coaches’ Association’s and the KABC’s region player of the year in 2015 and was a first-team all-state selection by both the Associated Press and the Courier-Journal.
Turner, who opens her first season as the Racers’ coach Sunday at Evansville, also landed three players that she coached at Murray High School – Alexis Burpo, Lex Mayes and Macey Turley. The program’s other signee is Sadie Hill of Indianapolis. | 2019-04-20T20:16:50Z | https://www.thegleaner.com/story/sports/2017/11/09/former-henderson-standout-outlaw-signs-murray-state/848489001/ |
If you are in need of an inspirational keynote delivered by a professional speaker at your next annual conference, sales meeting, convention or kick-off program contact one of the knowledgeable agents at the Collaborative Agency Group, a premiere speaker bureau, known for its global reach and roster of incredible story tellers. Our motivational keynote speakers come from varying backgrounds and have a wide range of speaker topics such as, inspirational stories, change management, life balance, employee engagement, leadership and teamwork, employee engagement, team building, real estate, human resources, overcoming adversity, personal development, peak performance, personal growth, communication skills, women’s issues, goal setting, corporate culture, patient safety, women in business middle east, global issues, cyber security, social media, business strategy, current affairs, and artificial intelligence.
An inspiring speaker is not defined by one trait and can come from a diverse set of backgrounds for instance, New York Times bestselling authors, Olympic gold winners, African American leaders, sports speakers, world champions, TV presenters, gold medalists, technology, business leaders, professional football, many different halls of fame, leadership speakers. Our keynote speaker roster is full of motivating and inspiring voices like Les Brown, Jim Abbott, Robyn Benincasa, and Mike Abrashoff in addition to many other top motivational and inspiring people.
When you the meeting planner is looking for an inspiring speaker or a motivational keynote, our website can be used as a event planners best resource and includes speaker categories for all of our motivational speakers. CAG’s lecturer agents are a leading authority on all things related to conference and international speakers. Whether you are looking for a hall of fame speakers, celebrity speaker or world record holder to motivate audiences, we can get back with you quickly on a speaker fee range or top ten motivational speaker list for your next event.
It doesn’t matter if your next event is in Washington DC, elsewhere in North America or the United Kingdom The Collaborative agency group can assist in booking the top speaker for your event. | 2019-04-25T00:50:49Z | https://cagspeakers.com/inspirational-speakers/ |
Voices for development: the Tanzanian National Radio Study campaigns.
This chapter traces the development of radio study groups in Tanzania from their initial unsophisticated beginnings in Moshi and Mbeya in 1967 to the massive organization involved in the latest health education campaign. The idea of radio listening groups was born in Tanzania in 2 different institutions and at opposite ends of the country at about the same time. The Cooperative Education Center in Moshi, founded in 1964, began with simple correspondence study guides as the main education method and then decided to support and enliven these courses by radio programs which presented the essential ideas and information in an oral form. In 1967 a similar experiment was launched in the Mbeya region. The 1970 study campaign on Tanzania's elections was an attempt to utilize various educational techniques to arouse civic interest and spread information about an event of great national political importance. From the perspective of educational methodology, it achieved several interesting results. It succeeded, in a limited fashion, in reaching people in nearly all areas of the country, and it made available to rural adult education workers the tool with which they could carry out an important but unfamiliar job. Yet, in the final analysis, the success of the study campaign depends on its impact on the development of Tanzanians' understanding of and participation in their democratic rights. This is not possible to assess. The pilot study campaigns in 1969 and 1970 had centered on important national events. The year 1971 was to culminate in the celebration of Tanzania's 10th anniversary of Independence. It thus was considered appropriate to link the 1971 radio study campaign to this national celebration. The feeling was that the campaign should attempt to do 2 things: to create a deeper sense of national awareness; and by tracing the development of Tanzania from the distant past up until the present, to highlight the achievements since Independence. The study materials consisted of 3 elements: a series of radio programs, a textbook, and a study guide. The campaign achieved a large measure of success. The fact that groups were established all over the country indicate that interest was aroused on a national scale. The campaign reached its intended audience, the rural section of the population. Another area which was thought to have been satisfactory is that of training. This was the 1st time that a 2-stage training program had been tried. The evaluation provides evidence that people can learn from this method as indicated by the statistically significant in socres from the pretest to the posttest. | 2019-04-21T08:34:46Z | https://www.popline.org/node/497219 |
You are asking about an impossible scenario. As far as I know, there was never any released version of Teradata that ran on a 32-bit Linux platform. Our Teradata for Linux releases have always been for 64-bit platforms. | 2019-04-26T10:29:37Z | https://community.teradata.com/t5/Database/Restoring-System-from-64bit-Linux-to-32-bit-Linux/td-p/8696 |
They say good things come in small packages...and this town is no exception. This "Best Small Southern Town" is filled with a rich art community and proud locals. It is located approximately 75 miles south of Charleston, South Carolina and about 50 miles north Savannah, Georgia.
In this "Best Small Southern Town", the mode of how to go around the city is made to be easily available for everyone. According to Geostat.org, 68.8%, prefer to drive alone, 15.8% do carpools and only 1.3% are using the public transportation. There are also 3.58% who do walk to work and 0.42% who uses their bicycle.
In Beaufort, education is deemed too important to be the sole responsibility of schools.. School discipline is instilled in the students and its success depends upon the collaborative effort of home, school and community.
There's nothing more satisfying than having a delicious and fulfilling meal at a restaurant where you can enjoy your solitude or the company of family and friends. | 2019-04-24T00:11:42Z | https://www.eraevergreen.com/beaufort-south-carolina |
Tales from the outback from exiled Kiwi journalist Colin Espiner.
So D-Day is almost upon us - or R Day, roadie day, the beginning of the grandiosely titled Great Australian Roadie. The girl and I will take to the Australian highway armed with nothing more than 4WD packed with the kitchen sink, cupboard and sideboard and every possible 4WD product available at SuperCheap Auto, from a folding shovel to a crocodile alarm.
It all seemed like such a long time in the future when we first hit on the idea of driving from Sydney to Perth the long way (ie via Cape York, and Darwin rather than straight across the Nullabor) but I must say it's come up rather fast. One minute you're pootling around Sydney in a modest hatchback wearing a suit and tie and the next you're clanking about in a smoky Nissan Pathfinder with wheels as big as small children and a blind spot the size of a small car (sorry about that dent). Dressed in Kathmandu's entire winter sales clearance.
In a nutshell, the plan was to chuck in our jobs (check), swap the hatchback for something a little bigger (check), and point it north out of Sydney's winter gloom for the sunny skies of Queensland and beyond (we'll come to that later).
Resigning on the day Fairfax announced 1900 job cuts and while News Ltd is embarking on similar retrenchment was a nice irony, I thought. Let's laugh in the face of the GFC (Australia's having its crisis a couple of years after everyone else) and quit before they can sack us. At least that way we keep our pride ... although the redundancy money would have been nice .... oh well.
So far all's going according to plan. News Ltd accepted my resignation with regret delight (thank you Colin! One less salary to pay! Oh and thanks for your work). The landlord grudgingly accepted the termination of our lease. And it's true - you really can't get enough of SuperCheap Auto.
After discovering there was simply no way of fitting everything we'd bought into the back of even a large 4WD, I've fitted roof bars and a basket to the top of the Nissan (called Chuck, partly because it rhymes with truck but mostly because the girl gets carsick) so now we look like a giant white shopping trolley. Not sure how it's going to handle the corrugated roads of the Outback, but we'll soon find out.
The first stage of the G.A.R is an easy drive up to Port Stephens, an idyllic hamlet around two hours' north of Sydney. At least, it was idyllic last time we were there. Mind you, that was summer. And it's now cold and raining. And we've only got a tent. But it's bound to get warmer as we head north, right?
Then it's Brisbane via Byron Bay, where a bloke called Jasper is waiting to fit a bull bar for us. I have no idea why we need a bull bar. I'm not planning on encountering any bulls. Or shoving anything. But several Australians have looked at our vehicle and mused, 'strewth mate, ya gonna need a roo bar on that where you're going'. So given such sage advice, who were we to argue?
After that it's Fraser Island, the Whitsundays, Cairns, Cooktown, and on up to the tip of Australia - Cape York - which from what we've been told is pretty much crocodile-infested swamp, bush, raging rivers that we're expected to drive across, mud, and at the tip, a corrugated iron shed with a sign on it congratulating you on reaching the northernmost point of the Australian continent.
If we survive that, we'll point Chuck west and head across the Savannah Way to the Northern Territory and the delights of Uluru, Kakadu, and Tenant Creek. Oh and Darwin. Then it's through the Tanimi Desert and up to Broome via the infamous Gibb River Road, which should shake loose what we haven't already lost off the roof earlier in the trip.
The plan is then to track down the west coast of Oz to hit Perth later in the year. 12,000km, 30 tanks of petrol and god knows how many spare tyres later.
PS I was kidding about the crocodile alarm. Although it would be useful.
Sounds like a great adventure Colin! All the best, I look forward to seeing what you get up to.
Oddly enough, only 3 posts in and you've already exceeded the amount of work you did in the last 18 months!!
It looks as though you had a great trip; it's been interesting following your travels over the last few months (from the anonymity of cyberspace). Well done! | 2019-04-20T18:52:20Z | http://redbulldust.blogspot.com/2012/06/so-d-day-is-almost-upon-us-or-r-day.html |
Samsung Galaxy On8 runs Android 6.0 Marshmallow. The smartphone has a 5.5-inch Full HD Super AMOLED display. This phone is succeded by Samsung Galaxy On Max. It has a 13MP rear camera with an LED flash and a 5MP front-facing camera. The device is powered by an octa-core Exynos 7870 processor and 3GB RAM. The latest ON series mobiles you may look for are Samsung Galaxy On7 Prime and Samsung Galaxy On6. It has 16GB internal storage which can further be expanded via a microSD card up to 256GB. Connectivity options include 4G, Wi-Fi 802.11 b/g/n, Bluetooth 4.2, GPS, and a microUSB 2.0 port. The device is powered by a non-removable Li-Ion 3,300 mAh battery.
Samsung Galaxy On8 Price starts at Rs. 10,490.
South Korean smartphone giants have introduced the latest variant of the Galaxy On Series of smartphones. The latest entrant is the Galaxy On8 which reflects a premium look and feel as the device is encircled by a metallic rim just like the Galaxy J7. Also, the home button on the front comes with a fingerprint scanner. It is available in gold, black and rose gold colours.
The Samsung Galaxy On8 sports a 5.5-inch Full HD Super AMOLED screen which is paired with excellent viewing angles. The screen also reproduces vivid images and there are no readability issues even if you are out in the sun.
For storing apps and media files, one gets 32GB of onboard storage space which can further be expanded using a microSD card up to 256GB.
Under the hood, the smartphone is armed with an octa-core Exynos 7870 chipset that ensures smooth and flawless smartphone experience. Even if you are a multitasker, the Galaxy On8 is equipped with 3GB of RAM to support your cause.
For shutterbugs, the Galaxy On8 comes with a 13-megapixel primary camera which is paired with an LED flash that can capture stunning images and record videos in both bright and dull conditions. For video calls and selfies, there is a 5-megapixel front-facing shooterTo the joy of selfie lovers, there is an 8-megapixel front-facing camera that can also be used for video calling.
Users can enjoy an array of connectivity options which includes 4G, Wi-Fi 802.11 b/g/n, Bluetooth 4.2, GPS and a microUSB 2.0 port. In addition, there is dual SIM support.
The Galaxy On8 is backed up by a Li-Ion 3,300 mAh that promises an entire day of battery life on a single charge for a moderate user.
Which mobile is best Samsung on 8 or Moto G4 plus?
I suggest you go with Samsung On8. It has perfect look and nice user interface.
For basic users on8 is best and for gaming go for G4.
Both are best in their places, but I am using On8.
Display resolution of Moto G4 plus is better.
Does it have good camera quality than J7?
Yes. The On8 can do HDR, whereas the J7 can't, and the front camera is also better under low-light conditions.
Yes, very good camera quality.
The camera quality is good.
How is the resolution of the phone?
It is an ok type. Regarding the display, I can clearly say, it is the best 1080p Full HD panel provided by Samsung. Also, you can use one of the four colour balance modes provided in the display settings of the phone. Now coming to the camera resolution, the rear one has 13MP, in good light it captures reasonably good images, colours are punchier and vibrant. But in artificial light, somewhat noise levels are high as it doesn't have OIS. Front cam with flash takes reasonably good photos. So, overall if you are Samsung fan, go with it. Otherwise, go for Moto G4 Plus and Redmi Note 3 or Lenovo k6 Power.
Resolution of the phone is mind-blowing. It has Full HD super AMOLED screen.
It is Full HD 1080p, very bright and vibrant and has AMOLED display.
It's best in quality, you can record full HD video of 1080p.
This phone has a super amoled display which is the best.
which one is best samsung j7 prime or on 8?
J7 Prime might be Rs.1000-1500 more than On8, On8 is more value for money. However, after using On8 for about 3-months, now, I have started facing some battery issues. The battery drains out in a jiffy from 100-0% in less than 3hrs with moderate usage on Jio 4G, and this never happened earlier. Previously, I was using J7 2015 edition for 13-months which I later gave to my dad. I never faced this problem in J7, and my dad is using it flawlessly now even after 16-months without any problems. So, maybe you should go for J7 Prime.
J7 Prime is better than On8 because J7 Prime has super AMOLED screen, and On8 has TFT screen.
J7 prime seems to have upgraded processor, but on8 wins for its super amoled display.
Both are equally good, I personally recommend On8.
Samsung Galaxy On8 is the best.
Which phone is better Samsung On8 or Lenovo K6 Note?
Currently, I am the owner of On8, both are little less than average. Still, On8 has a hanging problem, and the screen quality is not that great. Performance is fine, and the battery is really good. The sound is fine. Overall 6/10 Also, if you have really made up your mind to choose between these two, then go for On8.
Samsung On8 is best compared to any other mobile at this price.
Samsung on 8, it's display and picture quality is very good.
My opinion is Samsung Galaxy On8.
Best mobile with 3GB RAM.
It's operating fast and well.
Best mobile around 15k. All parameters are beyond excellence. Just go for it. Only point to compromise is quick charging, it's missing. | 2019-04-18T14:18:04Z | https://www.mysmartprice.com/mobile/samsung-galaxy-on8-msp11381 |
For nearly 25 years Peter Tsacle has worked as an animator, character designer, and art director in games and digital media. He was a key contributor to the classic Lucas Arts games Full Throttle and Grim Fandango, and spent the last decade at Telltale Games, leading animation teams on Wallace & Gromit, Back to the Future, Borderlands, and Telltale’s award-winning Walking Dead franchise. He has taught 2D and 3D animation for over 15 years here and abroad, and holds a B.A. in Film from San Francisco State University. | 2019-04-18T13:25:35Z | https://www.academyart.edu/academics/game-development/faculty/peter-tsacle/ |
RVCA Pipeline bikini bottoms. Features contrast piping details on front and back. Allover heathering. Hipster fit and cheeky coverage. 47% polyamide/46% polyester/7% elastane. Hand wash. Imported. | 2019-04-19T01:35:36Z | https://www.tillys.com/product/rvca-pipeline-hipster-bikini-bottoms/316694115.html |
Whereas we in the west speak of, and see, a “man” on the moon, the Chinese tell stories of and see a rabbit on the moon. Poet, playwright, and editor Joseph Coulson’s great first novel The Vanishing Moon (Archipelago Books, 330 pages) is hardly focused on the moon and yet it is, one might say, focused on the vanishing of beautiful things for which the elusive moon is a most, perhaps the most, romantic emblem: a unique book of pressed wildflowers; the innocence of children playing in the woods before they become conscious of a humiliating poverty; and the exceptional beauty of the unconsummated (preserving the sublime) over the requited (wallowing in the mire) sexual relationship. A good novel asks more questions than it answers and displays a sort of secret symmetry; that is more than the case here. Coulson’s compulsively readable multi-generational saga, a fugue of three first-person voices whose points of view and narrative overlap, is doubtless a powerful yet difficult way to craft a novel–as the intimacy of the “I” of each individual, pulling us into the depths of his or her consciousness, might seem to distract from the reader’s having a narrative center of gravity. This is not the case here, perhaps because the voices are partitioned among two sexes and three generations-tent-stricken poverty and the end of childhood innocence outside Cleveland during the Great Depression in the first part of the novel (my favorite), told by a young Stephen Tollman; the Midwest in the middle of the century, seen through the eyes of the intelligent and beautiful Marxist pianist Katherine (a love interest for both Stephen and his surly, fascinating,1950s-mold-macho older brother, Phil) in the second part of the novel, squeezed into shape by WWII; and greater Detroit in the era of the late-60s Tigers in the third part, told through James, broken Phil’s younger son, in the novel’s third, Vietnam-and-Summer-of-Love part. A shorter fourth section, set partly in San Francisco, returns to the voice of Stephen, now a grown man working as a supervisor in a General Motors auto plant, and still in love with what he can never have. Coulson’s fugue allows him to toggle between effects of extreme emotional intimacy, on the one hand, and panoramic narrative sweeps, on the other. The effect of the pulse-taking is that you feel you have had a genuine look into the cultural entrails–or under the hood, as it were–of the USA as it really ran throughout the whole middle of the 20th century. This is no mean achievement. I love John Fante (Charles Bukowski’s favorite writer, and author of Ask the Dust), and Coulson’s Phil Tollman–a stubborn man beaten by still more stubborn life–reminds me of them. Although Phil Tollman (who never narrates but is, nonetheless, the gravitational center of the novel) evinces less unpredictable charm than the Fante and Bukowski protagonists, his mold is quite similar-and because Coulson shows us so much more than merely a close-up of this captivating, never-say-die hard guy mold–he shows us the detailed world around it, the racial, feminist and social change that hardened it into its final form–his novel gives us the contrast, and context, with which to understand this secretly endearing American enigma. As the lusted-after Katherine, a relative sophisticate compared to the deprived, handsome Tollman brothers says while walking through the woods where their beautiful sister once played, “Everything is unbearably over with.” That is the nature of a kind of acute poetic consciousness, what Nabokov called “future memory”: she (although not my favorite character) sees, as they in the pain of the memory of their own suffering (their sister has died in these woods) perhaps do not, that even the presence of the present is fated to become a memory, and that that fate helps to constitute it, already always giving it, one might (getting a little carried away) say the melancholy melody of the moon. Coulson plays this sempiternal melody, with subtle panache and understated mastery, in the key of modern American history. Highly recommended (and much easier to get through than this review!).
This entry was posted in just literary fiction and tagged Bukowskian, interiority in fiction. Bookmark the permalink. | 2019-04-26T10:12:06Z | https://dactylreview.com/2010/08/18/the-vanishing-moon-by-joseph-coulson/ |
Reports the zero-based index of the first occurrence of the specified Unicode character in this string.
This method performs an ordinal (culture-insensitive) search, where a character is considered equivalent to another character only if their Unicode scalar values are the same. To perform a culture-sensitive search, use the CompareInfo.IndexOf method, where a Unicode scalar value representing a precomposed character, such as the ligature 'Æ' (U+00C6), might be considered equivalent to any occurrence of the character's components in the correct sequence, such as "AE" (U+0041, U+0045), depending on the culture.
The following code example demonstrates how you can search a String for a character using the IndexOf method. | 2019-04-20T00:29:40Z | https://docs.microsoft.com/en-us/previous-versions/windows/silverlight/dotnet-windows-silverlight/kwb0bwyd%28v%3Dvs.95%29 |
So here is a little bit of footage I managed to get my hands on – It’s not the best footage, but it shows all the little red dots floating around during the Coral Spawning, which seemed to be in abundance on Saturday night. The weather must have been just right. Video by Julian Dona.
Following on from the Queensland Multi-Media Awards, Greenbuddy has now been featured in City Life Magazine. A big thank you to all the team at City Life for there coverage of Greenbuddy – thank you guys!
City Life Magazine November Issue is in stores now.
Greenbuddy is moving to a new level, launching our brand new logo to help people further identify our Adventure Travel Blog here in Cairns, the Adventure Capital of Australia. We are currently trialing the new logo on some Adventure T-shirts to see how it looks! Stay tuned! We will be taking some photos and posting up the new designs next week.
Greenbuddy Wins Queensland Multimedia Award!
What a fantastic evening last night, with a great turn out for the 2010 Queensland Multimedia Awards, held at the Sebal International Hotel Cairns. I have to say a big thank you to all the judges and the sponsors of the evening, with Greenbuddy taking home best Online Editorial Feature/ News Story/ Blog.
It is the first award for Greenbuddy and I would like to say a huge thank you to all the people who voted. I will continue to use Greenbuddy as a platform to show adventure travelers and people from all over the world that Cairns really is The Adventure Capital of Australia.
What a fantastic day on Sunday! The sun was shining and the water was crystal clear, so I went out diving with my buddie when we came across two giant trevally being cleaned by a bunch of little ‘cleaner’ fish. I managed to get pretty close before they decided to swim away – take a look if you have 5 minutes. | 2019-04-23T16:07:25Z | https://greenbuddy.com.au/2010/11/ |
The exchange offices listed on this page allow you to convert Dash to NEM. Each of them had been thoroughly verified by us before they were included in the monitoring list.
In order to buy NEM for Dash, choose the preferred exchange (probably, the one with the best rate and optimal reserve) from the list on this page. Then navigate to the exchange site using the provided link. Follow the instructions posted on the site of the exchange office.
When buying NEM for Dash, please note that there are no more than 10 exchange offices on this page, that provide reasonable exchange rates. So if you want to see all the exchangers for the direction Dash -> NEM, click the "Show all".
If none of the exchanges on this page satisfy your demand for reserve, enter the amount of Dash, you want to buy, into the form above the exchanges list, and click "Calculate". After that, the system will hide all the exchanges with the NEM supply of lesser than the required amount.
If you want to convert Dash to NEM with an additional discount, register as client of the respective site after you navigate to it using our link. As a result, you can get a client`s discount, in addition to the one that provides Magnetic Money e-currency monitor.
* This graph displays the dynamics of average exchange rate for Dash to XEM conversion during the last 30 days. It is based of the data provided by the Magnetic Money monitor for e-currency exchange rates.
* This graph displays the dynamics of the total available reserve of XEM when converting Dash to XEM, during the last 30 days. It is based on the data from Magnetic Money. | 2019-04-23T00:45:56Z | https://magnetic-money.org/en/dash-to-nem-xem.html |
SVG engineer was established in April 25th, 2005. SVG engineer is a professional prestige construction consulting company.
SVG engineer supplys constructional services such as Investment consultancy, design consultancy, project management consultancy, construction supervision consultancy and Testing - Inspection - Attestation of quality of building construction.
All SVG engineer's constructional services are applied to follow ISO9000 : 2001 that TUV international Vertification Organization (Germany) recognized.
SVG engineer include many Vietnamese construction engineers and Foreign ones who are efficient.
SVG engineer is a member of International Consultancy engineer Association and TUV international Vertification Organization.
SVG engineer is a prestige construction consulting company. SVG engineer can deal many constructional problems such as Civil Construction, Transportation Structure, Irrigation Structure and Infrastructure.
8th Floor, Navy Guest Building, No.5 Ly Tu Trong street, Hong Bang district, Hai Phong city.
No.6/9 of 121 Le Thanh Nghi street, Dong Tam ward, Hai Ba Trung District, Ha Noi capital.
SVG Group office house, No.126 Dinh Bo Linh street, Binh Thanh district, HCM city. | 2019-04-24T18:32:14Z | http://svg-group.com/about-us-a7.html |
SLT Series Science Lab Table w/ Book Compartments (24" W x 48" L x 30" H) is rated 4.3 out of 5 by 3.
National Public Seating’s SLT Series Science Lab Tables are durable enough to handle heavy use in your science classrooms. These sturdy science tables are protected by a chemical- and water-resistant laminate, so they’re perfect for chemistry experiments and other potentially messy lab activities. Each lab table has a standard wood skirt and two roomy book compartments that let students store books, notebooks and other supplies during lessons. The solid ash hardwood frames give you a stable work surface, and adjustable leveling glides prevent wobbling. Available in several sizes.
Ordering science and lab tables for your school is easy. Just give our friendly sales team a call at 1-800-260-2776, or click a link below to choose a size and order online.
Rated 5 out of 5 by Roy G from Buding Chemist Needed a desk I bought this for use in my home. I have a son that has taken an interest in chemistry. We bought him a chemistry set for his birthday and it quickly became apparent that the little desk we had for him would not work out. This desk is great. It not only works out awesome for his chemistry fun but having a desk, a place for the chemistry set, had motivated our 10 year old to have an increased interest in something that will help build him up over the next few years. Its a great, very professional feeling desk and I recommend it to anyone needing a good desk for a little chemist to be.
Rated 4 out of 5 by Jim M from Well built This is one well made piece of furniture. I bought it for a computer workstation and my only complaint is the finish shows smudges readily. They shipped both leg heights which is generous.
Rated 4 out of 5 by rodgerskd from Sturdy and Durable! My 5th grade science class recently got these tables, and we love them! They are sturdy and durable, which is great for 5th graders! The tables also have the book compartments, which are a great size. They are a little narrow for 4 students, but overall, we are very pleased! | 2019-04-24T04:11:42Z | https://www.schooloutfitters.com/catalog/product_family_info/pfam_id/PFAM33093 |
Julia Broder -- July greetings from The Riverside Realty Group in beautiful Westport, CT! We've been working long hours in the Fairfield County real estate market as buyers want to cash in on some of the great luxe properties that are only now coming up for sale . . . amazing estates and new construction on beautiful parcels of land . . . and you can get some great inspiration from my Luxe Properties website! Visit it often for the latest and greatest in high-end real estate.
Talk about fireworks! I would love to show you outstanding high-end residences, Luxies. If you are confident that you can benefit from the prices in the market, then now is a good time to buy. Please contact me today at 1-203-247-7500 for more information on how we can work together. Wouldn't it be great to celebrate this wonderful season with a new home?
This month, I'd like to talk about how you might literally be able to lock your doors and throw away the key; key-less systems are worth looking into and are a big trend for home security. Steve Maxwell, the home improvement expert on casaGURU, Canada's favorite home improvement website, brings us some great tips . . . .
Most afternoons when I stepped off the school bus during my junior high years, Mom was home, but every so often she was away for some reason and that was always a good thing. It meant another chance to secretly sneak a chunk or two of Baker’s semi-sweet chocolate out of the white paper wrapper and into my mouth. It got to be a kind of Pavlovian thing.
Then one day the doorknob didn’t turn. All I had to do was reach for the hidden key and then enjoy a forbidden feast. Much to my surprise, the key wasn’t where it was supposed to be in the garage!
I guess I could have waited patiently in the backyard, but that option never occurred to me. There was chocolate at stake, a fact that I still maintain clouded my judgment beyond culpability. That’s why I tried wiggling in through the tiny hatch next to the back door that was built for milk deliveries. No luck there (too many chocolate raids in the past, I suppose).
Raised as I was on prime-time police adventure shows (arguably the only worthwhile cultural development to come out of the 1970s), breaking down the door seemed like the next best option. And it only took two attempts to bust the lock through the door frame, reducing a neat, 6-inch section of trim to smithereens. All I have to say about the event is that Dad was really pretty good about it all. So was the chocolate.
As the father of a high school youth myself now, I applaud technical developments that render chocolate-induced household damage a thing of the past. Key-free lock systems are popping up in reliable, reasonably priced versions for residential use and that’s a good thing for several reasons. All the people in your household need to remember are four single-digit numbers punched into the keypad and the door opens. Keys work, too.
Weiser is one of the pioneers of key-free technology and you can look into their Powerbolt System.
They started in the lock game 100 years ago with hardware used on Hollywood movie sets.
While I must admit that my natural tendency is to shun electronic gizmo's that have push buttons, looking under the hood on a key-free system proved more impressive than I expected. All electronic components sit on the inside face of the door, underneath a molded cover that includes the battery holder. The design proved reliable and easy to install for anyone who can use a screwdriver.
Key-free systems make more practical sense than ever in a world where members of most households come and go to the rhythm of their own drummer.
I’m sure key-free hardware will be standard equipment on homes within 10 years.
The system I’ve been looking at uses four AA batteries that operate a small electric motor that activates the deadbolt mechanism.
Keys work, too, just in case someone can’t remember their numbers or they fail to heed the low-battery warning signal. In normal use, a set of alkalines lasts about a year.
Although the keypad hardware measures 9 inches long, it’s designed to replace standard deadbolts that fit into the usual 2 1/8-inch diameter door hole.
If you ever find yourself needing to change locks because of a problem with lost or stolen keys, then a key-free system makes the most sense. If the access numbers ever get into the wrong hands in the future, reprogram the hardware for new ones. Just make sure that the chocolate lovers in your house are the first to learn the new numbers.
This article was reprinted with the permission of casaGURU. casaGURU is an everyday, everywhere, anytime homeowner website built on the premise that every home deserves a house expert. | 2019-04-25T05:57:41Z | http://www.irwinweiner.com/luxe-properties/2009/6/26/throw-away-the-key.html |
Versatility and ease steal the show in this essential. Part of our Ultimate Tee collection, now in an even softer combed cotton that effortlessly glides over your curves. Trapeze silhouette. Sleeveless. | 2019-04-18T19:24:08Z | https://www.roamans.com/products/ultimate-trapeze-tank/1036543.html |
People are being encouraged to spend five minutes talking about mental health as part of the second annual Time to Talk day. But talking isn’t the end goal, argues Mark Brown.
via BBC News – Viewpoint: Talking about mental health is just the first step. | 2019-04-26T05:56:28Z | http://healthy-minds.org.uk/bbc-news-viewpoint-talking-about-mental-health-is-just-the-first-step/ |
If you need a lawyer it can get very expensive. Here you can grab his FREE Report about Affiliate Marketing Ideas at or its partners. The house centipedes have at the outset come from the Mediterranean area and have stretched their growth throughout the world. Grooming is also a great bonding time and generally most dogs love the attention. These fraudulent discount coupons can be identified as they do not have two-part UPC code, no certain quantity and weight, and the fake coupon never states that the maximum is $5 on a single bag.
Flight School“I teach a freshman class, Introduction to Aerospace Design, and it's based on the MIT course.customizednewsletterservices. Well, unless you have nothing else to do and can chat with a tech support rep for a few hours while your account gets straightened out. Economists are concerned that if banks quickly dump their foreclosures on to the selling block, the market will experience declining home values to a point where more defaults and more foreclosures will take place.� From then on, I listened throughout the day for the parrots that separated into groups of from two to six and foraged within a 2-mile radius of their roosting site on Irena Street.Justifications of SmokingLet's take a look at a few common justifications and how you can overcome it. Reverse osmosis is so efficient at purifying water; it could actually even be used to desalinate sea water, however the ordinarily home system is not made for this purpose. These will also help you to keep tract of your purchases and budget. Many plumbing companies mail out coupons directly to houses, or offer a special on a particular service. | 2019-04-25T19:42:33Z | https://www.pflagvictoria.org.au/louisvuitton/louis-vuitton-pen-refill.html |
Thank you for stopping by our store. We want to do our very best to provide you with the Cheer Extreme clothing and other items that you are all looking for. We're always open to suggestions for new items and t-shirt design ideas. Please note that we are a small business and are not stocking hundreds of every size of every item. We do have an excellent supplier that will be able to keep up with our orders, so we will be able to get your items out to you very quickly using the US Postal Service. Just keep in mind that when you see an item on the site that you want, place your order as soon as you can before we run out. To keep things simple, the ONLY method of payment we will accept through this online store is PayPal. I have been personally using them for years and have NEVER encountered a problem, whether I was buying or selling. You can find them here: www.paypal.com.
When you set up your account with PayPal, you can have them draw the funds from either your personal bank checking account, or your favorite credit card. Neither CEA-TEES nor Cheer Extreme will EVER have direct access to your accounts through purchases made here. Thanks for shopping with us, and thank you for being a Cheer Extreme fan!
Content copyright . cea-tees. All rights reserved. | 2019-04-22T01:59:22Z | http://cea-tees.com/ |
Caravan Holidays and Holiday Caravans! Lovely park with easy access to sea and countryside. No pets. Families welcomed. Games room, swings, rocking horse and play area for children. Large open green areas on park. Laundry/drying and telephone facilities.
Look and Sea Centre Littlehampton.
By clicking "Submit" you certify that this review is based on your own experience and is your genuine opinion of "Brookside Park" and that you have no personal or business relationship with "Brookside Park" and have not been offered any incentive or payment originating from "Brookside Park" to write this review. | 2019-04-23T08:50:01Z | https://www.caravansitefinder.co.uk/parks/view/1009-brookside-park |
The Folklife Program collaborates with nonprofits, traditional artists and culture workers across the state to document, preserve and present Tennessee’s diverse folklife. Folklife is comprised of arts, expressive practices, and skills that are learned and passed down in cultural communities that share family, ethnic, tribal, regional, occupational, or religious identity.
Folklife grants are available to eligible organizations for project support and operating support. | 2019-04-25T06:08:24Z | http://tnfolklife.org/ |
If you are looking for a charming house, a countryside house or luxury villa with pool in the city of Dubrovnik you can find all of these across Dubrovnik riviera. This part of Croatia is famous for pleasant weather, amazing architecture and top quality cuisine.
If you are searching for a place for your family holiday or friends escape you should book one of numerous Dubrovnik villas in this area. Most of them are set in secluded locations, among Mediterranean greenery. They are ideal for relaxed peaceful holiday away from city crowds. In these villas you have everything you may need during your holidays. Each villa has outdoor area usually with pool equipped with deck chairs all around. Some villas have barbecue area where you can prepare food from local sources.
If you want to be close to the city to explore historical sights, you should rent villas in the city of Dubrovnik. Otherwise, you can rent villas in the surrounding areas like Konavle region or Cavtat as well as northwestern of Dubrovnik in Dubrovacko primorje and nearby Elaphite islands. Staying in these villas you can enjoy peace of countryside and be in the city in a short car ride.
Experience the holiday of your dreams, enjoy the luxury and comfort offered by luxury villas and villas with pools. These luxury villas will offer you a beautiful holiday close to the crystal clear Adriatic sea, or surround you with beauty and peace of clean, unspoiled nature which exudes history and tradition.
This five-bedroom villa is located in the great peaceful location on Babin Kuk peninsula. It can accommodate up to 9 people. Villa features spacious outdoor area where you will find outdoor pool and deck chairs. From the villa you can enjoy sea views and amazing summer sunsets. Villa has big kitchen and dining area where you enjoy prepared meals.
This villa has a great location south of the Old Town, only a short walk from two beautiful city beaches: Saint James beach and Banje beach. Villa is set in typical Mediterranean stone house with outdoor area equipped with sun loungers. The property can accommodate up to 8 people. From the villa you can enjoy amazing views over the Old Harbour and city walls.
This spacious villa is situated only 5 minute walk from the Old Town. It can accommodate up to 14 people. Villa Orti features fully equipped kitchen with dining room, living room with fireplace, 7 double bedrooms (with bathrooms), outdoor pool with showers, sauna with shower and toilet, equipped meeting room, outside grill, laundry room and separate wine cellar. There is also a garage with 4 parking spaces.
This amazing holiday home is located only a short car ride from the city of Dubrovnik. Villa Aridea can accommodate up to 6 people. Spacious outdoor area with pool and deck chairs makes this property ideal for relaxed summer holidays. Free private parking is available on site and free Wi-Fi is provided throughout the property.
This luxurious villa is set in the typical Mediterranean stone house only short walk from historic Old Town. It is surrounded by lush Mediterranean garden. The ground floor features two suites with en-suite bathroom, a large join salon with a toilette and completely equipped kitchen. The upper floor of the house features 3 suites with bathrooms - two of them have a large sunny terraces. The villa holds a mini gym, a sauna and a laundry room in basement.
This 3-bedroom villa is situated on a hill in Mlini, just 10-15 minutes' driving distance from Dubrovnik's Old Town. With a generous 220m2 of interior space over two floors, villa can comfortably accommodate up to 8 guests. A spacious outdoor terrace boasts a swimming pool, 6 sun loungers, a dining table and a summer kitchen with stone barbeque. The villa is sourrounded by a rich assortment of Mediterranean plants such as orange, lemon and olive trees which create a relaxing setting.
This spacious villa is situated in the village of Zaton, 9 km from the city of Dubrovnik. Villa Sana Via has two floors. In total there are 2 double bedrooms, studio apartment, 3 bathrooms and is suitable for up to 8 guests. Stepping out from the first floor you are on the terrace furnished with teak chairs and table for 8 people next to barbecue. Stairs lead to the lower level where you will find a swimming pool with Jacuzzi, outdoor shower, deck chairs and umbrellas. From the terrace and pool area you can enjoy amazing views over the bay and crystal clear Adriatic sea.
Villa Pugliesi is situated in a picturesque Zaton bay just 10 minutes driving from Dubrovnik. This stunning villa is a unique property set in a historical building from 16th century. Villa Pugliesi provides its guests with everything they need for the perfect holiday. The main building of 500 m2 spread over two floors and in the back of the villa extends beautiful Mediterranean garden which houses a swimming pool and even a private chapel of St Jerome.
This exclusive 5-star villa is situated on the hill above Mlini bay, only 15 minutes driving distance from the city of Dubrovnik. This amazing villa extends over three floors and includes four bedrooms and five bathrooms with the total capacity of 12 guests. On the ground floor guests can relax in private indoor/outdoor swimming pool which is equipped with a whirlpool, jacuzzi and pool bar. There is also sauna, fitness equipment and a mini wellness center.
This 5-bedroom villa is situated only a short walk from the Old Town and all Dubrovnik sights. It is located in the peaceful and quiet area only 300 metres from the sea. Villa can accommodate up to 10 people. This air-conditioned villa features 5 bedrooms, a well equipped kitchen with a dining area and a living room. Large outdoor terrace which is surrounded by Mediterranean garden for relaxing during hot summer days.
This spacious villa is situated in the area of Rijeka Dubrovacka, only 6 km from historic Old Town. With its 4 bedrooms it can accommodate up to 8 people. Villa has large outdoor area with pool and deckchairs as well as terrace with dining area. If you want to stay fit there is a gym inside the house as well as playroom. This villa is ideal for peaceful and relaxed family escape to the Mediterranean.
Even though the villa is located a mere 3 kilometres from the historic Old Town of Dubrovnik the natural surroundings of typical Dalmatian flora and fauna offer complete privacy and relaxation. Villa franco presents the height of comfort with a total of five rooms located over 3 levels which are all fully air-conditioned and centrally heated. The villas inviting swimming pool is ideal for keeping cool during Dubrovnik’s warm summer months and lies partly in the shade of soaring palm trees. | 2019-04-24T23:52:07Z | https://www.dubrovnik-travel-experience.com/dubrovnik-villas.html |
You are here: Home / Daily Blog / Drink water!
I was talking to an acquaintance yesterday, and was surprised when he said “I drink plenty of water every day because I drink lots of diet soda.” I told him that diet soda is not the same as drinking plain water, but he insisted that it is the same because it’s made of “mostly water”. I tried to explain that the caffeine was actually acting as a diuretic, but nothing I said could convince him that drinking soda is not the same as drinking fresh water.
Before my transformation started in 2003, I never drank water. My only fluid intake was soda, coffee and alcohol, all of which are diuretics. So how did I survive? Our bodies are great at adapting to adverse conditions, and I guess the little water I did get through foods was sustaining me. Of course my overall health was horrible back then. So can you survive on nothing but soda? Sure, but I don’t know for how long, and you’re definitely creating far from optimal conditions if your goal is health and/or fat loss.
When I stopped drinking soda and switched to water it was very difficult, but over time I came to love water. Now nothing refreshes me and quenches my thirst like water. I drink about 1.25 – 1.5 gallons per day. Other than coffee in the morning and the occasional alcoholic beverage, water is all I ever drink.
Wow, I’m out of time – it’s 2 minutes to 9:00 and after almost 5 years of updating this site by 9:00 AM without fail, I don’t want to be late for the first time today. Have a great day, and drink your water! | 2019-04-23T05:53:02Z | http://www.johnstonefitness.com/2007/08/15/drink-water/ |
Click the button below to add the 1922 Magazine Article All Weather Bus Comfortable year to your wish list.
below not for the item promoted in the AD.
Condition - Very Good - There could be small flaws but none of which would take away from the ad itself.Full Page ads are untrimmed. We will leave the trimming to you. | 2019-04-25T06:08:11Z | http://www.advintageplus.com/1922-magazine-article-all-weather-bus-comfortable-year/ |
1. Find the name of your counselor.
2. Type your Client ID# in the box.
3. Click on the "Pay for Counseling Button"
4. This will take you to a Paypal page.
5. Once there add your counseling payment to the Item Price and click "Update" below Quantity.
Pureheart Ministries is an official 501(c)3 Non-Profit. All donations are tax deductible. | 2019-04-24T07:47:10Z | http://www.pureheartministries.net/paydonate-new |
What is 1 cup milk in grams depends on the kind of milk under consideration. To change 1 cup of milk in grams we should know the density ρ of your milk, which, strictly speaking, is a function of the temperature and pressure conditions. Here, for use in cooking we assume the ρ of milk to be 1.03 g/cm3. Should you know the exact density of your milk, then you can get a more accurate result by using our converter below. How many grams of milk in a cup also depends of the size of your standard measuring cup. If you have been looking for 1 cup milk grams, then you are right here, too. Read on to find out what is one cup milk in grams.
To determine how many grams in a cup of milk we must figure out what cup you are using. A United States legal cup, used in food labeling, has a capacity of 240 ml. The Imperial cup size is 284.131 milliliter, the metric cup size is 250 ml, and the Canadian cup contains 227.3045 ml. Finally, the US customary cup is defined as 236.5882365 ml. If you are unsure about the unit of measurement, check your recipe, cookbook or plastic cup. Once the cup capacity has been found out we can continue with our 1 cup milk to grams conversion.
Using the formula m = cups * ρ * cup size with ρ of milk = 1.03 g/ml we get the following result for the mass m in grams.
Note that these 1 cup milk in grams results are approximations. If you know the density of your milk you should use our calculator below for an accurate result. You can, for instance, find the value by consulting a search engine or checking the label of your milk package. Alternatively, you can try our search function in the sidebar of this page to see if we have already converted 1 cup milk to grams for your particular kind of milk.
To obtain 1 cup of milk in grams using our converter enter 1 as cup size. Next, insert the density of your milk, followed by choosing the matching unit.
After that select your cup size; the calculation is then conducted automatically. This will give you the exact mass for 1 cup in grams milk.
This brings us to end of 1 cup to grams milk. If our article about one cup of milk in grams has been useful, then please bookmark us and share 1 cup milk in grams with other chefs.
We have shown you how to convert 1 cup milk to grams, yet if you have any questions about 1 cup to grams milk just leave a comment and we’ll be in touch.
Thanks for visiting 1 cup milk in grams on gramstocups.net. | 2019-04-20T14:24:04Z | https://gramstocups.net/1-cup-milk-in-grams |
P-TEFb phosphorylates RNA polymerase II and negative elongation factors to stimulate general transcriptional elongation. It is kept in a functional equilibrium through alternately interacting with its positive (the Brd4 protein) and negative (the HEXIM1 protein and 7SK snRNA) regulators. To investigate the physiological significance of this phenomenon, we analyzed the responses of HeLa cells and murine erythroleukemia cells (MELC) to hexamethylene bisacetamide (HMBA), which inhibits growth and induces differentiation of many cell types. For both cell types, an efficient, albeit temporary disruption of the 7SK-HEXIM1-P-TEFb snRNP and enhanced formation of the Brd4-P-TEFb complex occurred soon after the treatment started. When the P-TEFb-dependent HEXIM1 expression markedly increased as the treatment continued, the abundant HEXIM1 pushed the P-TEFb equilibrium back toward the 7SK/HEXIM1-bound state. For HeLa cells, as HMBA produced only a minor, temporary effect on their growth, the equilibrium gradually returned to its pretreatment level. In contrast, long-term treatment of MELC induced terminal division and differentiation. Concurrently, the P-TEFb equilibrium was shifted overwhelmingly toward the 7SK snRNP side. Together, these data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.
The elongation stage of eukaryotic transcription is a highly regulated process crucial for not only generating the full-length mRNA transcripts but also coupling transcription with pre-mRNA processing (24). Central to the elongation control is the positive transcription elongation factor b (P-TEFb), which stimulates the processivity of RNA polymerase II elongation and antagonizes the effects of negative elongation factors (1, 10, 20). The predominant form of P-TEFb in many human cell types consists of cyclin-dependent kinase 9 (CDK9) and its regulatory subunit cyclin T1 (CycT1) (20). It phosphorylates the carboxy-terminal domain of the largest subunit of polymerase II as well as the negative elongation factors DSIF and NELF (1, 10, 20). These phosphorylation events are crucial for the transition from the abortive to the productive phase of transcriptional elongation. For this reason, P-TEFb is considered a general transcription factor essential for the expression of a vast array of protein-coding genes (4, 22).
Recent evidence indicates that nuclear P-TEFb is kept in a functional equilibrium through alternately interacting with its positive or negative regulators (13, 29). For negative regulation, the associations with the HEXIM1 protein and 7SK snRNA sequester P-TEFb into a kinase-inactive 7SK-HEXIM1-P-TEFb snRNP (17-19, 30, 31). Within this complex (termed the 7SK snRNP), HEXIM1 inhibits the CDK9 kinase activity, whereas 7SK stabilizes the HEXIM1-P-TEFb interaction (17, 18, 31, 32). Besides HEXIM1 and 7SK, P-TEFb also binds to the bromodomain protein Brd4 to form a separate complex (13, 29). The association with Brd4 forms the transcriptionally active P-TEFb and recruits P-TEFb to cellular promoters. It is believed that the abilities of Brd4 to bind to acetylated histones and the transcriptional Mediator complex may facilitate the recruitment of P-TEFb to chromatin templates (13, 29).
In HeLa cells under normal growth conditions, about half of nuclear P-TEFb is sequestered into the 7SK snRNP, whereas the other half probably binds to Brd4 (13, 17, 29-31). However, treatment of cells with certain stress-inducing agents, particularly those that can globally interrupt transcription, such as actinomycin D, DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole), and UV irradiation, causes a rapid disruption of the 7SK snRNP and enhanced formation of the Brd4-P-TEFb complex (19, 30, 31). Furthermore, treatment of cardiac myocytes with conditions that cause cardiac hypertrophy has also been shown to induce the disruption of the 7SK snRNP and activation of P-TEFb (21). Because P-TEFb activity is limiting in normal cardiac myocytes, the activation of P-TEFb leads to a global increase in cellular RNA and protein contents and consequently the enlargement of heart cells, which is the cause of hypertrophy (21).
Despite demonstrations that P-TEFb can interact alternately with its positive and negative regulators and that the 7SK snRNP can be converted quantitatively into the Brd4-P-TEFb complex under certain conditions, the physiological significance of the P-TEFb equilibrium remains largely unknown. Moreover, only the conditions that can cause the disruption of the 7SK snRNP and enhanced formation of the Brd4-P-TEFb complex have been described so far (5, 19, 29-31). It is not clear whether there may exist reagents that can shift the P-TEFb balance in the opposite direction to increase the sequestration of P-TEFb into the 7SK snRNP.
Here, we addressed these two issues by analyzing the effects of hexamethylene bisacetamide (HMBA), a hybrid bipolar compound, on both P-TEFb activity and growth of human HeLa cells and murine erythroleukemia cells (MELC). Whereas HMBA retarded HeLa cell growth only weakly and transiently, it is by far the best-characterized suppressor of growth and inducer of terminal differentiation of MELC (15). Our studies have revealed intricate regulations of P-TEFb activity throughout the course of HMBA treatment. For both cell types, an efficient, albeit temporary disruption of the 7SK snRNP and activation of P-TEFb-dependent transcription were observed during the initial phase of the treatment. When the P-TEFb-dependent HEXIM1 expression was markedly elevated as the treatment progressed, the abundance of HEXIM1 caused the P-TEFb equilibrium to shift back toward the 7SK snRNP direction. For HeLa cells, the equilibrium quickly returned to the pretreatment level. In contrast, significantly more P-TEFb was sequestered into the 7SK snRNP in HMBA-treated MELC than in untreated cells. Together, our data indicate that the functional P-TEFb equilibrium is tightly regulated to accommodate the overall transcriptional demand as well as the growth or differentiated states of cells.
Materials.HeLa and 293T cells were purchased from the American Type Culture Collection (Manassas, VA). MELC were a generous gift from the laboratory of Alan C. Sartorelli. HIV LTR-luciferase cells are a HeLa-based cell line stably transfected with a luciferase reporter construct driven by the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) (30). F1C2 cells are a HeLa-based cell line stably expressing Flag-tagged CDK9 (CDK9-f) (30). Rabbit anti-CDK9 and -CycT1 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA). Rabbit immunoglobulin G, FLAG peptide, mouse anti-FLAG antibody, and anti-FLAG antibody conjugated to agarose beads were obtained from Sigma. Rabbit anti-HEXIM1 and anti-Brd4 antibodies were described previously (29, 31). Buffer D contained 20 mM HEPES-KOH, pH 7.9, 15% glycerol, 0.2 mM EDTA, 0.2% NP-40, 1 mM dithiothreitol, 1 mM phenylmethylsulfonyl fluoride, and various concentrations of KCl as indicated below. All other chemicals were from Sigma unless otherwise noted.
HMBA treatment.Fresh stocks of HMBA prepared in tissue culture medium were used for all experiments. HeLa cells or MELC were treated for the indicated time periods with either 5 or 10 mM HMBA as specified in Results. For growth rate assays, HeLa cells and MELC were treated with HMBA for the indicated periods, diluted in fresh media without HMBA at 1 × 105 per well in six-well plates, and allowed to grow for 2 or 4 days. Cell counts were determined using a hemacytometer.
Luciferase assay.HIV LTR-luciferase cells were seeded at 1.5 × 105 cells per well in six-well plates 1 day before the HMBA treatment and treated with HMBA. Luciferase activity was measured 48 h later with an assay kit from Promega.
Affinity purification of CDK9, CDK9-f, and their associated factors.CDK9-f and CDK9 and their associated factors were isolated by anti-Flag or anti-CDK9 immunoprecipitation from nuclear extracts (NEs) of the indicated cell lines. For most experiments, NEs prepared in buffer D containing 0.35 M KCl were used. For Brd4 detection, however, the extracts were dialyzed against buffer D containing 0.15 M KCl. After incubation at 4°C for 2 h, the immunoprecipitates were washed extensively. The Flag peptide-eluted (for anti-Flag immunoprecipitates) or sodium dodecyl sulfate-eluted (for anti-CDK9 immunoprecipitates) materials were analyzed by Western blotting with the indicated antibodies and Northern blotting using the full-length 7SK antisense RNA as a probe. The signals of HEXIM1 and CDK9 in the NEs or immunoprecipitates were quantified using an Innotech AlphaImager 2200.
Transcription assay.In vitro transcription reactions with mixtures containing NE from untreated or HMBA-treated HeLa cells and an HIV-1 template were carried out as described previously (34). G-less RNA fragments derived from in vitro-transcribed HIV-1 transcripts were isolated after RNase T1 digestion and analyzed on 6% polyacrylamide sequencing gels.
RT-PCR and Northern blot analysis.Total RNA from HMBA-treated or untreated cells was isolated using TRIzol (Invitrogen). Twenty micrograms of total RNA was resolved on a 1% formaldehyde gel, transferred to a nylon membrane, and analyzed by Northern blotting. 32P-labeled ([α-32P]dATP or [α-32P]CTP) cDNA probes for HEXIM1 and luciferase were generated using a Stratagene Prime-It random primer labeling kit. The 7SK antisense RNA probe was generated as previously described (30). For reverse transcriptase PCR (RT-PCR), DNA contamination was eliminated using DNA-free DNase treatment and removal reagents (Ambion). First-strand cDNA synthesis was carried out using Moloney murine leukemia virus reverse transcriptase as instructed by the supplier (Promega).
Chromatin immunoprecipitation.HIV LTR-luciferase cells (30) (2 × 106) were seeded into a 15-cm dish 1 day prior to HMBA treatment. Cells were treated with HMBA for 0 or 3 h, harvested, and subjected to a chromatin immunoprecipitation (ChIP) assay as described recently (29). After DNA purification, PCRs containing α-[32P]dCTP (800 Ci/mmol) were carried out for 20 cycles, and the products were analyzed on a 6% polyacrylamide-urea gel. Input and immunoprecipitated chromatin were analyzed first in pilot experiments to ensure that PCRs occurred in the linear range of amplification.
siRNAs.HeLa cells were cotransfected in a 1:10 ratio with pBabe-puro empty vector and pSuper-based constructs expressing small interfering RNAs (siRNAs) specific for the indicated proteins. To deplete CycT1, a CycT1-specific siRNA called siCycT1 was expressed from the pSuper vector containing a short hairpin sequence, 5′-CTCGTGTCCCTCATTCGAAACGCTTCCTGTCACGTTTCGAATGAGGGACACGAG-3′ (with the central hairpin region underlined). For Brd4 depletion, a Brd4-specific siRNA called siBrd4 was derived from a short hairpin sequence, 5′-GAACCTCCCTGATTACTATAAGCTTCCTGTCACTTATAGTAATCAGGGAGGTTC-3′. At 24 h posttransfection, untransfected cells were killed by the addition of 1.5 μg/ml puromycin into the culturing media. NEs were prepared at 48 h posttransfection. For HEXIM1 depletion, siRNA530 and siRNA562 (31), with the numbers referring to the positions of the beginning nucleotides of two separate 20-nucleotide regions within the HEXIM1 open reading frame, were employed. Two independent stable transfectants for each siRNA were selected with and maintained in 1.5 μg/ml puromycin and used in the experiment.
HMBA induces transcription from the HIV-1 promoter.We previously reported that HEXIM1 expression could be induced by HMBA in a variety of cell lines, including HeLa cells (33). Given HEXIM1's important role as an inhibitor of P-TEFb, we asked whether treatment of HeLa cells with HMBA and the consequent induction of HEXIM1 would have a negative effect on transcription. A stable HeLa-based cell line containing an integrated luciferase reporter gene driven by the HIV-1 LTR (30), which is known to be highly sensitive to P-TEFb (4, 9, 30), was used. Surprisingly, rather than causing an inhibition of transcription, HMBA induced expression from the reporter construct by several hundred-fold over an 8-h time period (Fig. 1A). Northern blot and semiquantitative RT-PCR analyses revealed that this increase occurred at the luciferase mRNA level (Fig. 1B). However, no increase was detected for the expression of the cellular gene encoding either the GAPDH (glyceraldehyde-3-phosphate dehydrogenase) protein or the 7SK snRNA. Finally, NE prepared from HMBA-treated HeLa cells caused a significant increase in transcription from the HIV-1 promoter compared to NE from untreated cells (Fig. 1C), indicating that the HMBA-mediated increase in HIV-1 gene expression could be attributed directly to an activation of transcription.
HMBA stimulates transcription from the HIV-1 promoter. (A) HMBA induces expression of the luciferase reporter gene driven by the HIV-1 LTR. A stable HeLa-based cell line containing an integrated HIV-1 LTR-luciferase reporter construct was treated with 10 mM HMBA for the indicated time periods. The level of induction (n-fold) in luciferase activity compared to that in untreated cells is shown. (B) The HMBA-induced increase in luciferase activity occurs at the mRNA level. Semiquantitative RT-PCR and Northern blot analyses were performed to detect luciferase mRNA from among total RNA isolated at various time points of a continuous HMBA treatment. The levels of the GAPDH mRNA and 7SK snRNA were also analyzed as internal controls. (C) NE from HMBA-treated HeLa cells significantly increases HIV-1 transcription in vitro. Reaction mixtures contained the transcription template HIV+TAR-G400 and NE prepared from cells treated with HMBA for 0 or 3 h. RNA fragments transcribed from a G-less cassette inserted into the template at a position ∼1 kb downstream of the HIV-1 promoter are indicated.
HMBA disrupts the 7SK snRNP.To seek an explanation for this dramatic increase in HIV-1 transcription, we examined whether, like certain stress-inducing agents and hypertrophic signals, HMBA could induce the disruption of the 7SK snRNP, thus releasing P-TEFb for transcriptional activation. Indeed, treatment of F1C2 cells, a HeLa-based cell line stably expressing FLAG-tagged CDK9, with HMBA caused a significant reduction in the amounts of HEXIM1 and 7SK associated with the immunoprecipitated CDK9-f (Fig. 2A). In contrast, the CDK9-CycT1 heterodimer formation was completely unaffected. The peak 7SK snRNP disruption occurred approximately 2 h after the treatment commenced (Fig. 2A, lane 8). Interestingly, a prolonged incubation with the drug (with fresh changes every 4 h) actually led to a gradual recovery of the 7SK snRNP (Fig. 2A, compare lanes 9 and 10 with lane 8), a point that will become clear later.
HMBA treatment of HeLa cells disrupts the 7SK snRNP and enhances the binding of P-TEFb to the HIV-1 chromatin template. (A) Treatment of HeLa cells with HMBA induces the dissociation of HEXIM1 and 7SK from P-TEFb. F1C2, a HeLa-based cell line stably expressing CDK9-f, was treated with HMBA for the indicated numbers of hours. CDK9-f, CycT1, HEXIM1, and 7SK present in NEs (lanes 1 to 5) and the anti-FLAG immunoprecipitates (αFLAG IP) (lanes 6 to 10) were detected by Western and Northern blotting. The presence of endogenous CDK9 (endo. CDK9) in NEs was revealed by anti-CDK9 Western blotting. (B) HMBA enhances the binding of P-TEFb to the HIV-1 chromatin template. The HeLa-based cell line with the integrated luciferase reporter gene driven by the HIV-1 LTR was treated with HMBA for 0 or 3 h. ChIP with anti-CDK9 antibody was performed. Three regions corresponding to the promoter region, interior region, and 3′ untranslated region (3′ UTR) of the integrated HIV-1 LTR-luciferase gene, as well as an interior region of the endogenous GAPDH gene, were PCR amplified from the precipitated and purified DNA. Numbers in parentheses indicate nucleotides. Amplified signals from 10% of the input chromatin are also shown.
HMBA-induced disruption of the 7SK snRNP causes more P-TEFb to bind to the HIV-1 chromatin template.We next performed a ChIP assay to determine whether the HMBA-induced release of P-TEFb from the 7SK snRNP would result in the association of more P-TEFb with the chromatin template containing an integrated HIV-1 LTR-luciferase reporter gene, thus causing activation of transcription. Quantification of the data shown in Fig. 2B revealed that treatment of the HeLa-based cell line with HMBA for 3 h indeed increased the binding of P-TEFb to the HIV-1 promoter region by 6.5-fold. In addition, the treatment also caused 2.5- and 1.5-fold more P-TEFb to bind to the interior of the luciferase gene as well as the 3′ untranslated region, respectively. In contrast, HMBA did not result in the association of more P-TEFb with the coding sequence of the GAPDH gene, in agreement with the observation that the expression of this gene was unaffected by HMBA (Fig. 1B, upper panel).
Prolonged treatment of HeLa cells with HMBA leads to reformation of the 7SK snRNP.The above-described partial restoration of the 7SK snRNP detected at 8 h of the HMBA treatment (Fig. 2A) prompted us to investigate the long-term effect of this drug on the formation of this complex. Quantification of the amounts of HEXIM1 associated with the immunoprecipitated CDK9-f at different time points since the commencement of HMBA treatment (with fresh changes of the drug every 4 h) confirmed that the HMBA-induced disruption of the 7SK snRNP was transient (Fig. 3A). By 15 to 18 h into the treatment, the amount of the 7SK snRNP present in the treated HeLa cells was restored almost to the pretreatment level and remained this way until the end of the 72-h incubation period.
Transient disruption of the 7SK snRNP, formation of the Brd4-P-TEFb complex, and activation of HIV-1 transcription in HMBA-treated HeLa cells. (A) Prolonged treatment with HMBA leads to reformation of the 7SK snRNP. HeLa cells were incubated with HMBA for the indicated time periods. Levels of HEXIM1 associated with the immunoprecipitated CDK9 derived from NEs were detected by Western blotting, quantified, and normalized to CDK9 levels, and they are shown as percentages relative to the pretreatment level, which was set to 100%. (B) HMBA transiently induces luciferase mRNA synthesis. Results are from Northern blot analysis of luciferase mRNA transcribed from the HIV-1 LTR in HeLa cells treated with HMBA for the indicated time periods. As a loading control, 7SK snRNA in total RNA samples was also examined. (C) Transient induction of luciferase activity in HMBA-treated cells. The level of induction (n-fold) in luciferase activity, expressed from the integrated HIV-1 LTR-luciferase reporter gene, was measured with a HeLa-based cell line treated with HMBA for the indicated time periods. pHIV, HIV-1 promoter. (D) P-TEFb alternately interacts with HEXIM1 and Brd4 throughout the course of HMBA treatment. NEs were prepared from HeLa cells treated with HMBA for the indicated durations and subjected to immunoprecipitation with anti-CDK9 antibody (αCDK9) (lanes 5 to 7) or, as a negative control (cntl.), anti-CDK4 antibody (lane 4). Brd4, HEXIM1, CycT1, and CDK9 present in the immunoprecipitates (IP) and NEs were examined by Western blotting.
Consistent with this observation, the luciferase mRNA transcribed from the HIV-1 promoter also showed a transient increase, peaking around 6 h after the treatment began, but was hardly detectable 72 h after the treatment began (Fig. 3B). Similarly, the HMBA-mediated induction of luciferase activity peaked around 12 h and then started to decline (Fig. 3C). A combination of factors such as the rates of mRNA processing, export, and degradation coupled with the time required for protein synthesis and maturation may contribute to the apparent 6-h delay in the accumulation of peak luciferase activity relative to the peak mRNA level. Furthermore, the relatively high stability of the luciferase protein may result in the detection of a considerable amount of its enzymatic activity in HMBA-treated cells even after the nuclear 7SK snRNP returns to the pretreatment level.
P-TEFb alternately interacts with its positive and negative regulators throughout the course of HMBA treatment.We have shown previously that the treatment of HeLa cells with certain stress-inducing agents, such as actinomycin D, DRB, and UV irradiation, causes a quantitative conversion of the HEXIM1-7SK-P-TEFb snRNP into the Brd4-P-TEFb complex (29). To determine whether HMBA could also shift the balance between these two P-TEFb subpopulations, the amounts of Brd4 and HEXIM1 bound to the immunoprecipitated CDK9 at 0, 6, and 24 h into a continuous HMBA treatment were analyzed by Western blotting. In contrast to its effect on the HEXIM1-P-TEFb binding, which decreased dramatically at the 6-h time point and returned to the pretreatment level at 24 h as described above (Fig. 3A), HMBA produced the opposite effect on the binding of Brd4 to P-TEFb by significantly enhancing it at 6 h and restoring it to the pretreatment level at 24 h (Fig. 3D). It has been proposed that P-TEFb is normally maintained in a functional equilibrium through alternately interacting with its positive (Brd4) and negative (HEXIM1 and 7SK) regulators (13, 29). The observation that P-TEFb switched back and forth between these two functional states during the course of HMBA treatment suggests that HMBA caused an initial, transient shift of the P-TEFb equilibrium toward the active, Brd4-bound state. However, over a more extended period of time, the treatment did not produce any long-lasting effect on the relative concentrations of the two P-TEFb subpopulations, as the equilibrium soon returned to the pretreatment level.
HMBA induces HEXIM1 expression in a P-TEFb-dependent manner.What might have caused a rapid resequestration of P-TEFb into the 7SK snRNP after the initial response to HMBA, a possible stress-inducing agent to HeLa cells, had subsided? One potential clue came from the observation that sometime between 6 and 12 h after the HMBA treatment started, the HEXIM1 expression began to increase significantly and its nuclear concentration remained four to five times higher than the pretreatment level for at least 72 h (Fig. 4A). It is possible that this major increase in HEXIM1 concentration coupled with a constitutively high level of 7SK snRNA (Fig. 1B and 3B) (27) might have pushed the P-TEFb equilibrium back toward the HEXIM1/7SK-bound state.
P-TEFb-dependent induction of HEXIM1 expression by HMBA. (A) HMBA treatment of HeLa cells increases HEXIM1 expression. HEXIM1 levels in NE of HMBA-treated cells were detected by Western blotting at various time points of the treatment. The HEXIM1 signals were quantified and normalized to those of CDK9 for each time point, and they are shown as percentages relative to the pretreatment level, which was set to 100%. (B) P-TEFb is required for HMBA-induced HEXIM1 mRNA synthesis. HeLa cells transfected with either the empty pSuper vector (−) or vectors expressing the CDK9- and CycT1-specific siRNAs (siCDK9 and siCycT1, respectively) were treated with HMBA for 0, 6, or 24 h. Total RNA was isolated and subjected to Northern blot analysis to detect the major 2.5-kb and minor 4.0-kb HEXIM1 mRNA. The 18S and 28S rRNA present in total RNA were stained with ethidium bromide and used as loading controls. (C) CycT1- and Brd4-dependent production of the HEXIM1 protein. Western blotting was performed to examine the levels of Brd4, CycT1, HEXIM1, and CDK9 in NEs prepared from HeLa cells transfected with either the empty pSuper vector or the indicated siRNA-expressing pSuper constructs at 48 h posttransfection.
Next, we asked how the HMBA-induced HEXIM1 expression was accomplished. We noticed that the onset of this induction occurred soon after the HMBA-mediated disruption of the 7SK snRNP and activation of P-TEFb. To determine whether P-TEFb was required for the HMBA-induced HEXIM1 expression, we performed Northern analysis to measure HEXIM1 mRNA levels in HeLa cells that expressed the siRNAs specific for CDK9 and CycT1. Indeed, compared to an empty vector, the siRNA-mediated depletion of P-TEFb caused a drastic reduction in levels of the HMBA-induced HEXIM1 mRNA at both 6 and 24 h of the treatment (Fig. 4B). Notably, the HEXIM1 mRNA was quite stable in the absence of the siRNAs, as its level remained relatively high at 24 h (Fig. 4B, lane 5), when the freshly liberated P-TEFb had been recaptured by 7SK/HEXIM1 (Fig. 3A).
The P-TEFb-dependent HEXIM1 gene expression was further confirmed by Western analysis (Fig. 4C), which showed that the CycT1-specific siRNA reduced the expressions of not only its intended target, CycT1, but also HEXIM1. Moreover, introduction of a siRNA specific for Brd4, the positive regulator of P-TEFb, also caused the codepletion of both Brd4 and HEXIM1 (Fig. 4C). Because these two proteins act in opposite directions to control the activity of P-TEFb, their coregulation implicated the existence of a cellular mechanism to maintain a balance between the two P-TEFb subpopulations for proper cell growth (see below). In summary, the observed strong dependence on P-TEFb for HMBA-induced HEXIM1 expression may explain why the P-TEFb equilibrium was shifted transiently toward the Brd4-bound active state during the initial phase of HMBA treatment, which in turn produced abundant HEXIM1 to eventually drive the P-TEFb equilibrium back to the pretreatment level.
HMBA exerts only a minor, short-term effect on HeLa cell growth.To understand why HeLa cells would want to resequester P-TEFb into the inactive 7SK snRNP once HEXIM1 gene expression was induced, we examined the effect on HeLa cell growth by either a 6- or a 24-h treatment with HMBA. Compared to results with untreated cells, whose numbers were artificially set to 100%, incubation with HMBA for 6 h had no detectable effect on cell numbers, which were counted at 2 and 4 days after the removal of the drug and are presented as percentages relative to those of untreated cells (Fig. 5A). Similarly, the 24-h HMBA treatment slowed cell growth only temporarily by about 30% measured at 2 days posttreatment, and the cell numbers returned largely to normal after another 2 days (Fig. 5A). Thus, despite the demonstrations that HMBA induced a transient disruption of the 7SK snRNP and induction of HEXIM1 expression, it apparently had only a relatively minor, short-term effect on HeLa cell growth. It is likely that this lack of a major, long-lasting effect by HMBA led to the resequestration of P-TEFb into the 7SK snRNP and restoration of the complex to its original level. Notably, the human embryonic kidney cell line 293T displayed exactly the same responses as HeLa cells to the HMBA treatment in terms of the kinetics and degrees of 7SK snRNP disruption/reformation as well as the growth rates (data not shown).
HeLa cells strive to maintain a constant level of nuclear 7SK snRNP for optimal growth. (A) HMBA suppresses HeLa cell growth only mildly and temporarily. Cells were either untreated or treated with HMBA for 6 or 24 h. After removal of the drug, cells were placed in fresh media at low but equal concentrations and allowed to grow for 2 or 4 days. Cell counts were determined and are shown as percentages relative to those of untreated cells, which were set to 100%. (B) Diversion of free HEXIM1 into the 7SK snRNP in HeLa cells expressing the HEXIM1-specific siRNAs. NEs were prepared from HeLa-based cell lines either containing the empty pSuper vector or expressing the indicated HEXIM1-specific siRNAs and examined for their HEXIM1 and CDK9 levels by Western blotting (lanes 1 to 5). Two independent cell clones (denoted by -1 and -2 after the siRNA designations) for each siRNA were analyzed. The NEs were also subjected to immunoprecipitation with either anti-CDK4 (αCDK4) (lane 6) or anti-CDK9 (lanes 7 to 11) antibody, and the indicated factors present in the immunoprecipitates (IP) were examined by Northern and Western blotting.
HeLa cells strive to maintain a constant amount of 7SK snRNP for optimal growth.The observations discussed above raised an intriguing possibility that the intracellular concentrations of 7SK snRNP may define and even help establish the growth states of cells. According to this hypothesis, when cells are not ready to undergo a major alteration of their growth state, they strive hard to maintain their nuclear 7SK snRNP at levels appropriate for the overall transcriptional demand of that particular state. Besides the P-TEFb homeostasis observed with HMBA-treated HeLa and 293T cells, additional evidence in support of this notion came from studies involving several HeLa-based cell lines that stably expressed the HEXIM1-specific siRNAs. It is known that in normal log-phase HeLa cells, a major portion of nuclear HEXIM1 exists outside of the 7SK snRNP and probably in free forms (3, 18, 31). Interestingly, when the total HEXIM1 levels in NEs were markedly reduced as a result of the expression of the HEXIM1 siRNAs (Fig. 5B, left panel), the amounts of HEXIM1 associated with 7SK/P-TEFb were barely affected (Fig. 5B, right panel). It is important to point out that the growth rates of these siRNA-producing cells were reduced only slightly and that we were able to establish and propagate them as stable cell lines without much difficulty. Thus, there was apparently an effort by these cells to compensate for the loss of HEXIM1 by mobilizing virtually all of the remaining free HEXIM1 into the 7SK snRNP in order to avoid a major perturbation of the P-TEFb equilibrium.
Enhanced sequestration of P-TEFb into the 7SK snRNP during HMBA-induced MELC differentiation.Despite the demonstration that HMBA displayed no long-term effect on HeLa cell growth, the above-described behavioral changes of P-TEFb during the course of HMBA treatment have nevertheless revealed an interesting connection between the functional P-TEFb equilibrium and the overall growth state of cells. To further test the hypothesis that nuclear 7SK snRNP levels are intimately associated with the critical cellular decision between growth and differentiation, we turned our attention to the effect of HMBA on MELC. It has long been recognized that HMBA is a highly effective and the best-characterized inducer of terminal differentiation (including terminal division) of MELC, which serves as a model for examining the control of erythroid differentiation (15, 16). In contrast to HeLa cells, whose growth was affected only mildly by treatment with either 5 (Fig. 6A) or 10 (Fig. 5A) mM HMBA, MELC were severely growth arrested when treated with 5 mM HMBA for 72 h (Fig. 6A) and, moreover, underwent efficient terminal differentiation under these conditions (15, 16; data not shown). At 10 mM HMBA, a significant portion of MELC was led to apoptosis after a prolonged incubation (23; data not shown).
Enhanced sequestration of P-TEFb into the 7SK snRNP and elevated expression of HEXIM1 in HMBA-treated MELC. (A) HMBA treatment of MELC severely inhibits cell growth. HeLa cells and MELC were either untreated or treated with HMBA for 72 h. Upon removal of the drug, cells were placed in fresh media at low but equal concentrations and allowed to grow for 2 days. Cell counts were determined and are shown as percentages relative to those of untreated cells, which were set to 100%. (B) NEs were prepared from MELC treated with HMBA for the indicated time periods and subjected to anti-CDK9 (αCDK9) immunoprecipitation. HEXIM1 associated with the immunoprecipitates (IP) or present in NEs were detected by Western blotting. The HEXIM1 signals were normalized to those of CDK9 for each time point and are shown as percentages relative to the pretreatment levels, which were set to 100%. (C) Diagram depicting the regulation of P-TEFb activity during the course of HMBA treatment. The 7SK snRNP is proposed to contain two copies of P-TEFb and HEXIM1 and one copy of 7SK (14). During the first several hours of HMBA treatment, the 7SK snRNP was converted into the Brd4-P-TEFb complex, which stimulated P-TEFb-dependent HEXIM1 gene expression. The elevated HEXIM1 levels then pushed the P-TEFb equilibrium back toward the 7SK snRNP direction during a prolonged HMBA treatment. For details, see Discussion.
Quantification of the amounts of HEXIM1 associated with the immunoprecipitated CDK9 indicated that the initial response of MELC to either 5 or 10 mM HMBA was a swift disruption of the 7SK snRNP (Fig. 6B), reminiscent of the situations seen with HeLa and 293T cells. However, unlike the last two cell lines, in which 7SK snRNP returned almost to the pretreatment level after a prolonged incubation (Fig. 3A; data not shown), MELC produced up to 2.9-fold more 7SK snRNP than was produced in the untreated cells as the treatment proceeded further (Fig. 6B, left panel). Moreover, the HMBA-mediated induction of HEXIM1 expression in MELC (11- to 14-fold) (Fig. 6B, right panel) was significantly higher than that in HeLa and 293T cells (4- to 5-fold) (Fig. 4A; data not shown), which could be responsible for the enhanced sequestration of P-TEFb into the 7SK snRNP in these HMBA-treated MELC, which were undergoing terminal division/differentiation. Taken together, our analyses of HeLa and 293T cells and MELC yielded consistent data which revealed a strong correlation between nuclear 7SK snRNP concentrations and the growth/differentiated states of cells.
Despite the demonstrations that P-TEFb is maintained in a functional equilibrium through alternately interacting with its positive and negative regulators (13, 29), the physiological significance of this phenomenon has not been demonstrated clearly. In this study, we analyzed the responses of HeLa cells and MELC to HMBA treatment in aspects such as growth properties, associations of P-TEFb with its regulators, and nuclear P-TEFb activities. Our data strongly support the notion that the functional P-TEFb equilibrium is tightly and dynamically regulated to reflect and accommodate the intracellular transcriptional demand as well as the proliferative or differentiated states of cells. Furthermore, among all of the agents that are known to affect the P-TEFb equilibrium (5, 18, 19, 30, 31), HMBA has been identified as the only one that can shift the P-TEFb balance toward the HEXIM1/7SK-bound state to increase the formation of the inactive P-TEFb complex in MELC.
As indicated in the diagram shown in Fig. 6C, the initial responses of both HeLa cells and MELC to HMBA are an efficient, albeit temporary disruption of the 7SK snRNP and liberation of P-TEFb. Since transcription from the HIV-1 LTR is known to be exquisitely sensitive to P-TEFb (4, 9, 30), the HMBA-induced activation of P-TEFb provides a molecular explanation for the previously described stimulatory effect of this drug on expression from the HIV-1 LTR, which has been characterized as independent of the NF-κB binding sites and other enhancer elements within the LTR (26). The HMBA-induced dissociation of HEXIM1/7SK from P-TEFb is also reminiscent of the situations seen with HeLa cells treated with certain stress-inducing agents that globally disrupt transcription and suppress cell growth (5, 18, 19, 30, 31). Since HMBA is able to inhibit the growth of both MELC and HeLa cells, albeit only transiently in the latter case, the induced shift of the P-TEFb equilibrium toward the active, Brd4-bound state could simply be an instinctive cellular response to this growth-arresting and stressful event. One conceivable consequence could be the activation of various stress-responsive genes. In addition, the activation of P-TEFb in MELC could lead to elevated expression of genes that play key roles during the commitment and establishment of the differentiated state (15, 16).
It remains to be determined how many genes can be activated directly by P-TEFb during the initial phase of HMBA treatment, what they are, and what roles they may play in the subsequent differentiation process of MELC. Nevertheless, we now know that there exists at least one gene, namely, the HEXIM1 gene, whose elevated expression is indeed caused by the HMBA-induced P-TEFb activation (Fig. 4). It is conceivable that accumulation of abundant HEXIM1 during a prolonged HMBA treatment is able to push the P-TEFb equilibrium back toward the 7SK/HEXIM1-bound state (Fig. 6C). After that, the intrinsic differences between HeLa cells and MELC in their responses to HMBA determine the final states of their nuclear P-TEFb equilibriums. For HeLa cells, since the treatment with HMBA produces no long-lasting effect on their growth, the P-TEFb equilibrium quickly returns to the pretreatment level. In contrast, MELC undergo terminal division and differentiation once they have passed through the commitment stage, which occurs as early as 10 to 12 h after commencement of the treatment (6). As a result, the P-TEFb equilibrium is shifted overwhelmingly toward the inactive 7SK snRNP side to accommodate an altered transcriptional demand in these cells that can no longer divide. Despite the implication of P-TEFb in this process, it is important to stress that we actually cannot tell at this stage whether the increased formation of the inactive P-TEFb complex in HMBA-treated MELC is a consequence of or a contributor to growth arrest and terminal differentiation of these cells.
Nevertheless, the tight coupling of the P-TEFb equilibrium with the global control of cell growth and differentiation agrees well with the demonstrated growth-regulatory functions of the P-TEFb-associated factors. For instance, as a negative regulator of P-TEFb activity, HEXIM1 has been shown to display an antigrowth function in cardiac myocytes, where the deletion of the mouse HEXIM1 (CLP-1) gene causes the enlargement of heart cells, reminiscent of a pathological condition known as hypertrophy (12). Interestingly enough, hypertrophic agents that induce the disruption of the 7SK snRNP also cause the same disease (21). In both cases, the deletion of the HEXM1 gene or dissociation of HEXIM1 from P-TEFb achieves the same goal of activating P-TEFb, which provides the necessary means to deal with an increased transcriptional demand under these highly proliferative conditions. As with its role in cardiac myocytes, HEXIM1 has been recognized as an inhibitor of breast epithelial cell proliferation, as its expression is down-regulated by estrogens and decreased in breast tumors (28). Finally, a recent report indicates that ectopic expression of HEXIM1 causes growth inhibition and promotes neuronal differentiation (25).
In contrast to HEXIM1, Brd4, the positive regulator and recruitment factor for P-TEFb, has been implicated to play a growth-stimulatory role. While mice lacking both alleles of the Brd4 gene are embryonic lethal, Brd4-heterozygotic mice display pre- and postnatal growth defects associated with a reduced proliferation rate (11). In addition, Brd4 is required for the proper progression of the cell cycle, as heterozygotes display a significantly reduced number of mitotic cells compared to wild-type tissues (11).
The opposing effects on cell growth exerted by Brd4 and HEXIM1, both of which target P-TEFb but produce antagonizing results, further support the idea that controlling the activity of the general transcription factor P-TEFb, which affects expression of a vast array of genes, is critical to the cellular decision between growth and differentiation. Besides its role in MELC, P-TEFb has been implicated to play a role in regulating the differentiation programs of several other cell types, including skeletal muscle cells, monocytes, lymphocytes, and neurons (2, 7, 8). However, only the expressions of CDK9 and CycT1 have been monitored in these studies. Future investigation of the P-TEFb equilibriums and their control by Brd4 and HEXIM1 in these cells will be very informative toward the understanding of the general roles of P-TEFb and transcriptional elongation in the global control of cell growth and differentiation.
We thank Rieko Nishimura for experiments involving the HEXIM1 siRNAs and Vivien Lee for technical assistance. We also thank Dalibor Blazek and Matija Peterlin for providing us with good-quality HMBA.
This work was supported by grants from the National Institutes of Health (AI41757) and the American Cancer Society (RSG-01-171-01-MBC) to Q.Z.
Returned for modification 15 June 2006.
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Vlach, J., and P. M. Pitha. 1993. Hexamethylene bisacetamide activates the human immunodeficiency virus type 1 provirus by an NF-kappa B-independent mechanism. J. Gen. Virol. 74:2401-2408. | 2019-04-25T19:11:13Z | https://mcb.asm.org/content/26/19/7068?ijkey=0c51bd4df5fc47e35e1f6db77139f203bb7b586b&keytype2=tf_ipsecsha |
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Apple has finally embraced Make in India vision - But will it work?
Apple too has joined the Make in India dream now.
Apple recently started to manufacture iPhone 6S in India at its Bangalore facility after a good run with iPhone SE. A recent surge in import duties has forced the technology major to increase the prices of iPhones in the country.
The iPhone sales have seen a 50 percent drop since the last two quarters.
Be it the higher prices or cheaper alternative flagships, Apple has already started on work a different business model in the country. The company is now aiming at a brand-first model, where it will focus on its brand, and not volume. The new model may pay off for Apple India in long term.
Reportedly, Apple has began manufacturing certain models of iPhone at its Bengaluru facility through a contract manufacturer. Apple already manufactures iPhone SE in the country, and also recently added iPhone 6 to its Indian production facility.
But the latest report suggests that the company is making certain number of iPhone models in India now.
The centre has informed the company is manufacturing certain iPhone models in India, but such details of private business decisions are not maintained by the Parliament.
Apple India has already seeked help from the government to support its manufacturing unit in the country. Centre has received requests seeking concessions which also includes duty exemption on manufacturing. Apple India has seeked concessions from the government on repair units, components, and consumables required for manufacturing.
The company is facing tough competition from the Chinese OEMs in the country. Recently three senior sales executives have left the company as well, owing to difficulties in selling iPhones in India.
While the smartphone giant has done exceptional business worldwide, Apple has suffered to do good business in the country. In spite of selling 3.2 million iPhones last year, Apple could not even sell half a million units in the country in the first six months of 2018.
Apple CEO Tim Cook still believes that India will be the next China, where Apple has its second largest market outside US.
Even in the premium segment where once Apple used to lead has fallen to a mere 20 percent in the first quarter of 2018. Currently, Apple India has an overall market share of around 1.5 percent to 2 percent. The iPhone sales in India rose consistently since 2014.
In the previous three years, Apple shipped nearly 8 million iPhones in India.
Now as Apple India has started to manufacture certain iPhone models, it can help Apple to build its brand presence and save on import duties, making iPhones more affordable in India helping the sales to grow.
India has now become the second headquarters for OnePlus as it’s growing at an extraordinary rate in the country. The Chinese brand today announced that it will be launching its latest retail stores in the country at Mumbai, Bangalore and Kolkata on 28 July.
By adding more offline stores and service centres, the company is aiming to improve the overall customer experience in India.
OnePlus is planning to open more than 10 new offline OnePlus Experience stores across the country along with an R&D centre by the end of 2018. It opened its first store at Bangalore last year.
OnePlus is offering an exclusive ‘Back To School’ discount for students with a flat Rs 1,500 Off on its latest flagship OnePlus 6 with 20 percent off on OnePlus accessories. The OnePlus ‘Back To School’ offer is now live, and will remain valid till July 30.
With OnePlus ‘Back To School’ offer you can get a flat Rs 1,500 discount on the latest OnePlus 6 using HDFC Bank debit and credit cards. The OnePlus student discount offer is also valid on its accessories where you can avail discounts up to 20 percent.
Ths OnePlus ‘Back To School’ offer is not available on Amazon. To avail the OnePlus student discount, you need to visit the OnePlus’ online store or any of its exclusive OnePlus offline store for OnePlus ‘Back To School’ offer.
"Apple Has Started Making Certain iPhone Models in India, OnePlus To Launch New Stores", 5 out of 5 based on 5 ratings.
Rail Enquiry On Whatsapp – This Is How You Can Do It In 2 Easy Steps!
Elon Musk Working On Tesla Smartphone? Is It An iPhoneX Clone? | 2019-04-24T12:09:21Z | https://trak.in/tags/business/2018/07/24/apple-has-started-making-certain-iphone-models-in-india-oneplus-to-launch-new-stores/ |
He looks at the bags of cat food. Free range, grass fed, wild game. He finds the most expensive one. It’s an animal he’s only seen on late-night nature shows.
He looks in his wallet.
He puts the food back and gets the third most expensive one. The smallest bag. Just enough for one meal. A last supper.
He pays the cashier in torn and spilling rolls of quarters, his earnings from the last dive. He’s been diving a lot lately, most of it intentionally. Diving, never surfacing. He needs fast money. But it comes slowly, like the choked water down the Dahisar in Mumbai. Or what he remembers of it. Even his memories come slowly now. Like traffic over the GWB at rush hour. His imagery has been transplanted, too.
You’re a buck short, says the cashier, a teenager with horn-rimmed glasses, after counting through the small change a second time.
I’m not a buck short, he says, waving his fingers in the air before her face.
That’s weird, don’t do that, she says, but she rings it through anyway.
He tucks the bag under his arm and heads out into the rain. People lurk under eaves and in doorways like rats, watching the sky with narrowed eyes, waiting for better weather that will never come.
He cuts up Broadway. Even thirty years later it seems alien to him. Billboards the size of ships, faces of giants on marquees. Musicals, concerts, performances.
He stops under a fifty-foot video screen, images transforming across its surface. A man in a tux, half-naked bored looking women hanging from either arm, sparks flying from his hands, becoming doves flying across the uncaring face of the Statue of Liberty.
He knows a rougher kind of magic. His father had been a street magician. He’d go with him, at dawn, to set up in the bazaar. To hold the hat while his father made small things appear and disappear for tourists. His hands traced intricate patterns in the air: a bird’s wings, waves, an explosion.
His father wore simple clothes, except for one indulgence: a brooch that he pinned in his turban. A tear from Shiva that became a ruby when it fell to earth, he’d tell the tourists, even though he was an atheist and knew nothing of religion. It would catch the sunlight and send dazzling shapes across the square: a beetle’s shell, stained glass, starlight.
He remembers the first time he saw his father’s hands slide a watch from someone’s wrist. Gentle. The motion of a lover. The tourist was blinded by light reflected into her eyes. His father’s brooch. She never even noticed.
From then on, all he could see were rings, bracelets, sunglasses. Foreign objects. For his father, the translation was tonight’s meal, new clothing, school books. But to him each sleight of hand, each flash of the brooch, slightly diminished the magic.
When his father was dying he gave him three things: a ticket, a kiss, a small box.
On the plane ride over the ocean, he opened the box. There was a wad of cotton. Wrapped inside it: the brooch. Out of the sunlight, in the shadows of the cabin above the clouds, he saw it for what it was.
He can feel it there, in his pocket, as he catches the 7 under the East River, leaving the neon and noise behind him. He slides the brooch out, running his thumb over the chipped surface. He holds it up, sending prisms of light around the train car. He telegraphs his every move in Morse code pulses.
I’m stepping onto the platform, I’m going up the street, I’m opening the door.
She’s where he left her, curled up next to the leopard-print sofa, almost camouflaged, stripes against spots. She moves her great head blindly, as he shuts the door, sniffing him out.
He sits on the floor beside her and runs his hand under her throat, pulling her chin up toward him. She’d purr if she had the strength. Wet pieces of leather are scattered around her. She’s chewed his boxing gloves to pieces, looking for his smell.
He opens the bag of food and feeds her by hand, one pellet at a time.
She only gets a few down before her head sags, resting in his lap.
He throws the brooch, clattering, on the coffee table: cheap, plastic, tinted pink. Next to it: a yellow slip of paper and a torn envelope. His invitation to the fight. His chance to reappear.
He used to watch his father swim his hands through the air of the bazaar. The brooch, the ruby, a third eye. The magic he could do. The things he would build.
He puts one hand under her jaw and clamps the other over her nose, plugging the nostrils. She hardly struggles, she’s already asleep. He’s making her disappear, just like he’s made himself disappear. He’s cast half a spell. Nobody taught him the second half. | 2019-04-23T00:48:52Z | https://www.harkback.org/round-6.html |
"EASA certifies ATR 72-600 passenger-cargo version" is part of ATW Plus, our online premium membership. Subscribing will provide you access to exclusive news, carefully researched airline financial, fleet and traffic data, plus the option to receive our popular, award-winning print magazine. To learn more, click here. If viewing via ATW Mobile, please login and click "Read web article" to view fully. Questions? ATWPlus@penton.com. | 2019-04-19T06:28:45Z | https://atwonline.com/airframes/easa-certifies-atr-72-600-passenger-cargo-version |
As a result, at the beginning of the Commission developed a „ EU Strategy for Plastics in the Circular Economy“. Global bioplastics production capacity will more than double european from to 20/ ( Packaging Essentials ) - - Capacity is predicted to pass the one million tonne mark already in according to a current study presented by the industry association European Bioplastics in cooperation sheet with the University of Applied Sciences Arts. This month, Mr [. Braskem’ s capacity of production I’ m green™ polyethylene production: 200kton/ year 460 sheet millions liters of Ethanol = approx. european Processors suppliers interviewed at the European Bioplastics conference in Germany early this month made clear they see a bright future for extruded applications made from the various bioplastics commercially available in late- stage development. The CO2 used is a waste product from a neighboring chemical company. Classification of bioplastics based sheet on origin and method of production. Each edition of Film Sheet Extrusion will be kept on- line for at least 12 months building into a valuable information resource. European sheet Bioplastics Association estimated that 58% of 1.
The current bioplastics production capacity could cover a significantly higher share. estimation of European Bioplastics). Production of bioplastics is anticipated to increase to 6 million tons by ( european Figure 15. Click on the links below to view the relevant magazines free of charge. Study of the Environmental Impacts of Packagings Made european of Biodegradable Plastics List of illustrations Figure 1: Packaging sheet consumption by sheet type of plastic in Germany ( ).
capacity to produce capacity an A4- sized PET aerogel sheet. 68 thousand hectares Source: Braskem - I’ m Green ™ european polyethylene. , european bio- based PET and PE) will account for the large growth in bioplastics production capacity in the future. The fabrication technology is also easily scalable for mass european production. Author: In text " According to definitions of the European Bioplastic Association ( Bioplastics Magazine a) these. Closing loops with bioplastics european A key element of the European Commission' s Circular Economy Package published in December is the shift from a linear economic model to a circular economy. 16 million metric tons global bioplastics capacity in was bio- based. 8 Figure 2: Plastic consumption by application in the packaging sector in Germany. European bioplastics production capacity sheet.
Other technologies have also advanced enough sheet to allow for production european on an industrial scale in the mid- term. Global sheet bioplastics capacity will see almost a fivefold increase from to. European Bioplastics expected that bio- based, non- biodegradable plastics ( e. possible the mass production of these petrochemical polymers , bioplastics virtually capacity disappeared ( compare the case of fuels where biobased fuels that were initially used for combustion were. European sheet Bioplastics; european PLA World Congress;.
The company has european invested some 15 million euros in the new plant sheet which has an annual production capacity of 5 capacity 000 metric tons. as more more bioplastics production facilities be- come operational within the next years they could poten- tially cover the complete EU plastic carrier bag consumption within less than a decade.
FACT SHEET European Bioplastics Benefits, feedstock types, sustainable sourcing, land use. production capacity is expected to multiply to 2. European Bioplastics Fact Sheet: Benefits, feedstock types, sustainable sourcing, land use Bioplastics – an important part of the bioeconomy The European bioeconomy aims to activate the potential of biobased products and generate new markets and industries while enhancing the sustainability of production and consumption. Over 50% of bioplastics are currently produced in Asia, whereas 20% of the production capacity is located in Europe. With the European Commission’ s commitment to the circular economy, production in Europe is predicted to grow to up to 25% by. The global bioplastics industry' s production capacity is set to increase to 6.
1 million metric tons from 4. 2 million tonnes by, according to the trade group European Bioplastics.
World wide production capacity of bio based plastics unitl comparison of old and new projections; Shares of bio based plastics by types in Europe based on company announcements; European production capacity of bio based plastics until comparison of old and new projections. Mr Axel Beyer, Plastic Engineer at the strap production of Mosca GmbH In each issue of the Bioplastics Bulletin, we present five facts about a member of European Bioplastics. | 2019-04-18T15:29:32Z | http://dolateyar.tk/european-bioplastics-production-capacity-sheet.html |
In the great city of Pattaya there is so much to do, see and experience and Blue Olives Gentlemens Club is definitely something you are going to want to experience for yourself.
While there are several Gentlemens Clubs scattered across the city Blue Olives which opened in November 2018 really is one of the best having had no expense spared to make sure all customers’ needs are well and truly met.
Blue Olives Gentlemens Club is the perfect place to relax and spend time with friends, set out over two floors the venue is kitted out with plush leather sofas ideal to kick back and relax and forget the hustle and bustle of the world outside.
The lounge is fitted with multiple air-con units insuring that although the lovely ladies that work there might get your temperatures elevated the lounge itself stays nice and cool.
There is a private pool free for customers to use should you wish to take a dip. Finally there are two large well stocked bars inside the lounge which contain a vast collection of domestic and imported drinks both alcoholic and non-alcoholic. Feeling hungry not a problem both western and Thai food is available at very competitive prices.
Blue Olives Gentlemens Club can be found in the Cozy Beach area of Pratumak which is a short distance behind the famous Pattaya City sign located towards the Bali Hai end of walking street. The venue itself is about 10-15 minutes’ drive from the center of Pattaya depending on traffic and is easily reached via taxi. The club is located next to the Cliff Condominium adjacent to Kasetsin Soi 3.
With a large abundance of beautiful girls working to make sure all customers’ needs are met, daily happy hours and awesome drinks promotions Blue Olives will surely be a place you will want to visit again and again.
For more information including up to date drinks promotions and happy hours head over to the Blue Olives Facebook page.
Professional at all times and deliver and truly amazing experience.
Nice venue, i love it. Wil be back again next month. | 2019-04-24T02:24:50Z | https://lovepattayathailand.com/listing/blue-olives-gentlemens-club/ |
The lively, full of twists plot reveals a dark secret little by little. The film combines humor with elements of horror.
Best Director Award at the first International Film Festival in Odessa 2010. | 2019-04-20T12:29:20Z | https://distribution.tvn.pl/offer-feature-films,1426,1/the-lullaby,241060.html |
We've 0 windscreen repair technicians covering the Fakenham area.
How much does a windscreen repair or a windscreen replacement cost in Fakenham?
The cost of repairing or replacing a windscreen in Fakenham can depend on the make and model of the vehicle (new models tend to have more features so will generally cost more to fix). Labour rates will be higher or lower depending on where in the country you are. The technicians featured above cover Fakenham so give them a call or click on the “GET A QUOTE” tab above and complete the process of getting a windscreen repair, replacement, side or rear window replacement quote online.
It’s always best to contact a qualified mobile windscreen technician who covers the Fakenham area. Someone who can come to you, and they can repair or replace your windscreen, side or rear window, whilst you carry on with your day.
We’ll send you a selection of great value quotes from technicians in Fakenham.
You can compare all the quotes to choose the best deal in Fakenham, before booking a local windscreen repair or replacement technician. | 2019-04-25T22:32:50Z | https://www.mywindscreen.co.uk/local-windscreen-repair-and-replacement-fakenham/ |
The Sheraton Grand Bangalore is 44 kilometres from the airport. Private transport to and from the airport is readily available. We recommend either availing the services of our dedicated hotel chauffeurs or booking a pre-paid taxi. Get the latest details of your flight with the Bengaluru International Airport. | 2019-04-26T15:37:35Z | https://www.iprconference.com/gipc/2019/venue.php |
\n\nAt the back of my mind, a remaining design issue had been nagging at me, and I figured out how to fix it this morning.\n\nThat means going back and regenerating all the artwork at various sizes and all the work after that point, too. I was thinking, “There’s an hour or two I’m not going to get back.”\n\nThen I remembered the days of typography unions, physical paste-up, burning plates, and printing back in the 70s and 80s. Back then, it took an hour just to drive to the typographer and back.\n\nSuddenly, an hour or two seems like nothing. | 2019-04-21T16:17:56Z | http://desamo.graphics/graphic-design-changes-over-the-years/ |
Find out information on history and origin of Kumbh Mela.
Kumbh derives its name from the immortal Pot of Nectar, which the Demigods (Devtas) and Demons (Asuras) fought over, described in ancient Vedic scriptures known as the Puranas. It is these Vedic literatures that have stood the test of time, out of which the tradition has evolved into the one that the world now knows as The Kumbh Mela. Legend tells a tale from the bygone days of the universe when the demigods and the demons conjointly produced the nectar of immortality. The demigods, because cursed, were crippled of fear that eventually made them weak. The task being too sturdy for them alone, the demigods made a mutual agreement with the demons to complete it in full and share the nectar of immortality in half. It is said that the demigods and the demons assembled on the shore of the milk ocean that lies in the celestial region of the cosmos. And it began!
For the task of churning the milk ocean, the Mandara Mountain was used as the churning rod, and Vasuki, the king of serpents, became the rope for churning. With the demigods at Vasuki’s tail and the demons at his head, the churning began. At first, the churning of the milk ocean produced a deadly poison which Lord Shiva drank without being affected. As Lord Shiva drank the poison, a few drops fell from his hands which were licked by scorpions, snakes, and similar other deadly creatures. Also, during the churning, the Mandara Mountain began to sink deep into the ocean, seeing which Lord Vishnu incarnated as a great tortoise and supported the mountain on His back. Finally, many hurdles and 1000 years later, Dhanwantari appeared with the Kumbh of immortal nectar in his hands. The demigods, being fearful of the demons' ill intent, forcibly seized the pot with its safety entrusted onto the four Gods - Brahaspati, Surya, Shani, and Chandra.
Demons, after learning that their part of the agreement has not been kept, went after the demigods and for 12 days and 12 nights, the chase continued. Wherever the demigods went with the pot of nectar, fierce fighting ensued. It is believed that during this chase, a few drops from the Kumbh fell at four places - Allahabad, Haridwar, Ujjain, and Nasik. There is also a prevalent legend that it was actually the demons that were being chased by the demigods for 12 days and 12 nights, during which the drops of elixir of immortality fell at these four places. These four places are since believed to have acquired mystical powers. Because 12 days of Gods are equivalent to 12 years for humans; the Kumbh Mela is celebrated once every 12 years in each of the four places - banks of river Godavari in Nasik, river Kshipra in Ujjain, river Ganges in Haridwar, and at the Sangam of Ganges, Yamuna, and Saraswati in Allahabad, where the drops are believed to have fallen. Millions of devout, come together to partake in ritualistic bathing and ceremonies to cleanse themselves of all sins. | 2019-04-25T20:01:24Z | https://www.kumbhamela.net/origin-of-kumbha-mela.html |
›LA Linen TCOrgz51R-LilacO45 Sheer Mirror Organza Round Tablecloth, Lilac - 51 in.
LA Linen TCOrgz51R-LilacO45 Sheer Mirror Organza Round Tablecloth, Lilac - 51 in.
Our 51'' Round Organza tablecloth is Light weight ,see through and has a solid shine finish. This type of tablecloth best work as an added color on top of a any solid tablecloth. The edges are serged and colors stay vibrant after many uses. This tablecloth need to be ironed on a very low setting as it is very delicate. | 2019-04-23T18:31:09Z | https://www.walmart.ca/en/ip/LA-Linen-TCOrgz51R-LilacO45-Sheer-Mirror-Organza-Round-Tablecloth-44-Lilac-51-in/PRD0V6REJUW5YET |
This a complete Rostra cruise upgrade kit for the 2016.5-2019 Chevy Cruze. This kit is applicable to the new body style only. Not the old body style 2016. If you are unsure of which one you have, please call. This kit is applicable to the automatic transmission only. Installation instructions included. This kit does NOT require dealer programming. Please call with any questions on this kit.
When you buy a Chevy Cruze LS instead of a LT you don't get cruise control. Everyone needs cruise control. So thanks to The Cruise Control Store you can add their after market cruise control. I'm not a mechanic but I have work on cars all my life. I am a DIY person. I was shocked how easy this was to install. I had one question about the installation and I called the number on the invoice. Spoke with a technician and he answered my question quickly and easily understandable. It works just like LT equipped cruise control. Been in for over a month. No issues. Very satisfied. | 2019-04-19T08:59:50Z | https://www.thecruisecontrolstore.com/250-9543-2016-5-2019-chevy-chevrolet-cruze-complete-cruise-control-kit-auto-transmission/ |
Crossfit Red Bluff is a premier training facility in the Bayside area of Melbourne servicing the suburbs of Highett, Sandringham, Black Rock, Hampton, Brighton, Beamauris, and Mentone. We are on a mission to improve the lives of our members by helping them achieve their true athletic potential in the safest, most enjoyable way possible.
CrossFit has been called the Sport of Fitness. We sprint, lift heavy things, jump, row, climb, and throw. This training program shows us how to move safely, functionally, and carries our fitness levels over into every aspect of our lives. Whether it’s chasing little kids all day, working physically demanding jobs or just satiating a lust for longevity, CrossFit is a proven fitness regime that will exceed your fitness expectations consistently.
WHY CROSSFIT RED BLUFF ?
At Crossfit Red Bluff we hold fast to the philosophy that position is king. This is something that co-owner Adam learned in his time interning at San Francisco CrossFit with Mobility Guru Kelly Starrett. We push the importance of balance in this life and believe that with intensity has to come recovery. We don’t have a whiteboard to write down your scores or to see if you RX’d a wod or not…all we care about is that you moved safely and did the workout to the absolute best of your ability.
We provide journals for our athletes to record their progress in so they can keep track of personal goals as opposed to comparing their performance to that of other athletes.
In our gym you are family. Whether its your first day or you’ve been with us since day one we will welcome you with smiles and usually a friendly game of Nerf tag. We joke around and love to laugh but will always push you to work as hard as you possibly can. No matter what, if you give it your all and do not give up you will see amazing results. | 2019-04-21T15:18:39Z | http://crossfitredbluff.com.au/ |
Across Canada, doctors’ views on medical assistance in dying are complex and occur on a spectrum. In our film, we feature two respected Canadian doctors, Louis Roy and Wendy Johnston. Drs. Roy and Johnston perspectives on the new law and its implications on their profession are a window to the sentiments shared by healthcare providers across the country.
In Road to Mercy, we meet Dr. Wendy Johnston, Professor of Neurology, and Medical Director at the University of Alberta’s ALS Clinic.
Dr. Johnston's patient John Tuckwell has ALS (Amyotrophic Lateral Sclerosis), a terminal, neurodegenerative disease. The Alberta court granted him the right to a medically assisted death in May, before the federal government's new legislation was passed.
While at Oregon Health Sciences University (1992-2000), Dr. Johnston established the first ALS clinic in Oregon and conducted a study on the attitudes of ALS patients and their caregivers toward assisted suicide; the study was published in The New England Journal of Medicine. In 2000, Dr. Johnston moved to Edmonton where she re-established the ALS Clinic at University of Alberta, now an interdisciplinary clinic and research program.
Given her extensive experience working with ALS patients and her time in Oregon, Dr. Wendy understands patients’ interest in assisted death, especially when diagnosed with a disease like ALS. However, she doesn’t think that it’s wise to offer it as an option during the early stages of the illness.
ALS causes the nerves that control your muscles to die. It leads to a loss of mobility, speech, and eventually the ability to breathe. Around 250 Canadians are diagnosed with ALS annually, and an estimated 3000 are living with the disease. ALS patients generally die within 5 years of diagnosis. They are the second highest users (after cancer) of medical aid in dying.
In her research and experience, Dr. Johnston found that it is "the fear of future suffering ... and of losing autonomy" that prompts many ALS patients to request an assisted death.
Studies in Oregon have shown that many patients who opt for an assisted death do not follow through. Since 2011, there have been 724 prescription recipients, and only 466 assisted deaths reported in Oregon.
In Quebec, a reported 253 patients have requested MAiD between December 2015 and July 2016. However, only 166 have received it. Of the 87 who did not receive it, 16 changed their mind.
Dr. Johnston makes her position clear on providing medical aid in dying, “I just can’t do it". However, she is open to having the conversation with her patients, “I’m not compromised personally by talking about it … I’m just not okay with providing it myself … I can’t cause a death intentionally”. | 2019-04-25T10:25:59Z | http://roadtomercyfilm.com/news/2016/9/7/dr-wendy-johnston-als |
File photo of Montgomery from the 2012 Air Force game.
"We appreciate the work Jerry did in his two seasons here with the defensive ends and continuing to help build the foundation on our defensive line. We wish Jerry, Natalie and their entire family nothing but the best.
"You always hate to lose members of your staff, but you know going in that at a program like Michigan, other schools and NFL teams are going to come after them. However, I am confident that we will name a new coach who fits in very well with our staff soon."
So there you go. Everything you need to know, nothing you don't. Interesting that Brady mentioned NFL teams coming after Michigan coaches. We'll never get an explanation on that one, but curious that he would say that. It could just be that he was saying that as a general comment. Or, if there was actually recent interest by a staffer with an NFL team, or vice versa? We may never know. | 2019-04-24T18:18:04Z | https://www.maizenbluenation.com/2013/02/brady-hoke-statement-on-montgomerys.html |
It appears that especially in the first part of the fourth quarter, Check Point experienced a sharp rebound in its business, wrote analyst Elan Zivotofsky of Goldman Sachs. He estimates that the company showed a strong positive trend early in the fourth quarter, and that this trend was sustained throughout the quarter, although in a more moderated form.
I’m glad I’m not a sell-side analyst. I think it’s an awfully tough gig. There isn’t a more derided profession among the blogs or journals I read. They are generally viewed as clueless, their ratings useless, and their estimates garbage. Most of this I would agree with. However I find them incredibly useful.
Next time you see something stupid written or stated by an analyst keep this in mind: You aren’t paying them anything for their advice.
This is an important point. Why on earth would you expect to get anything useful out of someone where you aren’t giving them something in return?
I on the other hand do give them something. Money. Lots of it. And I do that because they help me do my job better. Let me explain how the whole sell-side industry works.
A sell-side analyst typically covers a set of stocks within some sector. For example they might be an Internet analyst or a oil refining analyst. They then do research on these companies, talk to management, create some financial models, forecast some earnings per share numbers, slap a rating on the stock (buy, sell, hold), gain insights on the status of the company, formulate opinions on the effects of market news on that company, and write all that up in ongoing reports. That report is usually what is commented on in stories.
When you hear that “the street estimates” or “consensus earnings numbers” for a stock are so and so, this is just an average of all the sell-side estimates.
In general the estimates, ratings, and reports are largely useless. What is presented to the public is throwaway stuff. In some ways I don’t understand why they do it at all. Nevertheless let’s continue.
Conferences. Sell-side firms will line up a ton of companies and have them present at a conference. This gives someone like me a very effective way to see companies present and also meet the senior management. I can meet 8 companies in a day this way.
Access to management. Beyond meeting companies at conferences they are also useful for getting you a meeting with management. This isn’t always a problem. Usually I can call them directly and get a meeting. But not always. If not they usually come through for me.
Act as sector educators. If you are new to a field, the analyst will come to your office and sit down for an hour or two and walk you through how an industry works, who the players are, give some perspective on the history of the industry and so on. Invaluable.
Data they don’t write about. A sell-side analyst typically has to keep a decent relationship with management or they will be less forthright with that analyst. Also their investment banking wing might be doing investment banking work with that company. A conflict of interest to be sure but a reality in the market place right now. So what they write in reports is rarely the whole story. A call to an analyst usually leads to some additional information or more color on an event that is happening. Why did a senior executive leave for example. Usually they know. A ‘neutral’ rating might really be a ‘sell’ in their mind. Henry Blodget got busted after the Internet bubble popped for writing one thing in his reports and writing something completely different in his emails to colleagues and clients.
Models. No one really uses a sell-side model as it stands. But it represents a great way to start building one. They’ve kept track of all the historical data and metrics and you can use this to quickly build a model of your own.
Bus tours. These are the best. You head out to some are like Silicon Valley and they tour you around different companies. This is better than meeting management, which you do on the tour, because you also get to see the other employees and the work environment. It gives you a better sense of how the business works and the character of the company.
So how do sell-side analysts get paid. This is an interesting and I’m sure archaic way of doing business. Analysts get paid with soft dollars. As opposed to hard dollars where you write a check, soft dollars are allocated during a ‘voting’ process.
Twice a year we are asked to allocate 100 votes across the brokers we use for research help. They tally up the votes and then allocate trading to those brokers in proportion to the votes collected. If Goldman gets 4% of the votes it gets 4% of the trading we do. Goldman then makes money off those trades and this is how the sell side analysts are paid. There has begun a slow movement to kill soft dollar payments. In other words there is a movement to disaggregate the trading and the research. In the future we may very well send trading to the low cost provider or the best executor and write a check to the analysts. That doesn’t happen now but I think it will in the future.
So just keep that in mind next time you hear one of these guys spouting off. What they are telling you is useless. But then again, sell side analysts, to paraphrase the words of Chris Rock, aren’t there for you. | 2019-04-19T16:15:22Z | http://www.chookyfuzzbang.com/2008/06/sell-side-analysts.html |
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By closely analysing the contributions of such theorists as More, Hobbes, Vico, Montesquieu, Ferguson and Millar to the emergence of sociology in its original form, this book follows the discursive construction of sociology in the context of the society-wide early modern practical discourse about violence and rights. Parallels with the nineteenth- and twentieth-century discourse on poverty and justice, and the contemporary discourse of risk and responsibility, allow the author for a reflection not only on the generation of knowledge through discourse but also on the role that sociology itself plays in this process.
This book examines a number of important contemporary environmental issues. The topics covered include sewage treatment, eutrophication, air pollution, acid rain, global warming and pollution from farming. A particularly valuable section of the book describes a range of tests that can be carried out on various environmental parameters. The procedures require relatively simple equipment and they have been pre-tested in a school laboratory.
The work explores the spread of French science and culture beyond the borders of France, and focuses on the deliberate measures enacted by successive French governments to make such dissemination as effective as possible. This well-established French tradition is explored over time particularly since the closing years of the twentieth century. There is a very full description of the institutions, both former and current, established by France in the many locations worldwide. Soft power is redefined and contrasted with the more familiar hard power across the arts-to-science spectrum. The propagation of ideas and practices abroad is demonstrated in terms of a diplomatic push through varying and differing means and channels. Francophone initiatives are underscored, including the roles of French-speaking countries both as receptors and generators of French culture. The 2011 New Start is highlighted, reorienting action for the arts and for science and university diplomacy, particularly those aspects receiving increasing attention. International cooperation, both linguistic and educational, is seen as key to government involvement through the organization and implementation of French cultural and scientific activities abroad, and these are described in later chapters. Philippe Lane steers us through a myriad of acronyms for which he provides a very useful list.
W. E. Gladstone towers over the politics of the nineteenth century. He is known for his policies of financial rectitude, his campaigns to settle the Irish question, and his championship of the rights of small nations. He remains the only British Prime Minister to have served for four separate terms. In 1998, an international conference at Chester College brought together Gladstone scholars to mark the centenary of his death, and many of the papers presented on that occasion are published in this volume. Covering the whole of the statesman's long political life from the first Reform Act to the last decade of the nineteenth century, they range over topics as diverse as parliamentary reform and free trade, Gladstone's English Nonconformist supporters, and his Irish Unionist opponents. The collection forms a tribute, appreciative but critical, to the Grand Old Man of British politics.
The first edition of this book included essays from Senator George J. Mitchell, Sir David Goodall, Sir George Quigley, Lord Owen, and Niall O'Dowd among others, and demonstrated the evolution of peace in Ireland, culminating in the Good Friday Agreement. It has now been updated with new essays to ensure that this vital resource for students, scholars, politicians, and the interested general reader continues to illuminate the peace process through the words of some of its pivotal figures. The essays all relate to the nature of peacemaking as a process rather than an event signalled by the signing of an agreement. The significant role of ‘third party’ diplomacy is touched on by many contributors, as is the need for pragmatism, compromise, and a recognition that it is those people at the polar extremes of any dispute that have to be drawn in if a lasting agreement is to be achieved.
The MacBride Principles contained nine affirmative action proposals aimed at eliminating religious discrimination in the employment practices of United States corporations with subsidiaries in Northern Ireland. The weapon used by the MacBride campaigners was the federal constitution of the United States. States and cities in the Union could pass their own corporate legislation incorporating the MacBride Principles and use their pension fund investments to table shareholder resolutions seeking the Principles' inclusion in employment policies. Later developments saw their application to US and foreign firms supplying goods and services to states and cities. Using devolved legislation, the MacBride Campaign broke the stranglehold on the discussion of Irish issues maintained by the US, UK and Irish governments in the Congress. It was debated in state legislatures and city councils. Irish-America was motivated to participate in a nonviolent campaign to achieve social justice in Northern Ireland. Supported by the United States government, there was a fierce reaction by the British government to the Principles. Its attempts to suppress them were unsuccessful.
For almost a hundred years, the academic study of migration concentrated on evolving standardised models of migration behaviour based on data from censuses or the registration of births, marriages and deaths. More recently, it has been realised that such models fail to take into account the decision-making behind migration and that better understanding will come from study of the behaviour of individuals as well as aggregate numbers. In this book the imaginative use of alternative sources – for example, apprentice books, guild and craft records, legal and court documents, diaries and biographies – gives fresh insights into the processes of movement to reveal much more complex circulatory behaviour than the standard models derived from census and registration sources alone have suggested. The first chapter confronts the issue of rural mobility in post-famine Ireland and is followed by a study centred on Alpine rural families that built impressive networks across pre-industrial Western Europe. Two chapters focus on the particular characteristics of worker groups: mining families of south Lancashire during the period of rapid increase in coal production in the eighteenth century; and the organised mobility of skilled labour in nineteenth-century central Europe. Next, a rigorous deployment of the techniques of family reconstruction and record linkage embracing a variety of sources (vital event registers, wills, port books, apprentice records) teases out the migration histories of those who settled in eighteenth-century Liverpool.
Modern philosophical thought has a manifold tradition of emphasizing ‘the moment’. ‘The moment’ demands questioning all-too-common notions of time, of past, present and future, uniqueness and repetition and rupture and continuity. This book addresses the key questions posed by ‘the moment’, considering writers such as Nietzsche, Husserl, Benjamin and Badiou, and elucidates the connections between social theory, philosophy, literary theory and history that are opened up by this notion.
National-level spatial planning in democratic countries has been all but ignored by researchers in urban and regional planning since the reconstruction years following World War II. Being synonymous for many with repressive regimes and coercive government practices, national-level planning also fell into some disrepute. A set of specially commissioned papers from leading researchers has produced this comprehensive study of current national-level planning in ten countries of the developed world. Challenging common assumptions, this comparative international study finds that there seems to be a modest trend whereby, on the threshold of the twenty-first century, national-level planning has grown in importance in democratic, advanced-economy countries.
This book is an assessment of the ideological and organizational development of Provisional republicanism since 1985. It explores how the Republican movement has changed from an anti-state insurgency to a potential partner in governing the state it was pledged to destroy, and, in particular, attempts to consider the origins of what has become known as ‘New Sinn Féin’.
This book is a study of the constitutional and political development of the Isle of Man. It analyses three broad aspects of twentieth-century political development: constitutional progress towards self-government, elections and public policy and the changing role of the state in Manx society. One of the most important political changes the study addresses is the gradual ascendancy of the directly elected House of Keys in Manx politics. The book concludes with a look at the final two decades of the century, a period of population growth and unprecedented prosperity for the small offshore island.
Policing in Northern Ireland : Delivering the New Beginning?
The Independent Commission on Policing for Northern Ireland, headed by Lord Patten, concluded in its 1999 report: ‘A new beginning for democratic accountability is key to a new beginning for policing and to involving the community as a whole in the delivery of policing. We recommend that an entirely new Policing Board be created …’ This book is about the delivery of that new beginning for policing, achieved at a time when most commentators considered the Policing Board was itself likely to fragment along traditional community lines. The story of the Policing Board, from its establishment in 2001 through to the reconstitution of the membership in 2009 is in many ways an inspirational one, showing what can be done by politicians and community representatives working together to bring about a fundamentally different way of policing that better meets the needs of the whole community. The book offers valuable lessons and contemporary insights for law enforcement officers, accountability ‘bodies’ and academics world-wide, in key areas, including the need for a police service’s composition to reflect the community that it serves, promoting public confidence in policing and policing with the community; upholding human rights in the context of policing civil unrest and terrorism; how to hold a police service to account while providing the support it requires; and dealing with the legacy of inter-communal violence with over 3,500 deaths.
J. T. Murphy was one of the most important worker-intellectual figures in the history of labour in early twentieth-century Britain. Using material from the Communist Party of Great Britain's archives and the Russian Centre for the Preservation and Study of Recent History in Moscow, this book not only tells the story of Murphy's political trajectory, but also provides a critical re-examination of the historical and social significance of the early British revolutionary movement in which he played such a prominent role.
Max Weber's The Protestant Ethic and the Spirit of Capitalism continues to be one of the most influential texts in the sociology of modern Western societies. Although Weber never produced the further essays with which he intended to extend the study, he did complete four lengthy Replies to reviews of the text by two German historians. Written between 1907 and 1910, the Replies offer a fascinating insight into Weber's intentions in the original study, and the present volume is the first complete translation of all four Replies in English.
The question of religion, its contemporary and future significance and its role in society and state is currently perceived as an urgent one by many and is widely discussed within the public sphere. But it has also long been one of the core topics of the historically oriented social sciences. The immense stock of knowledge furnished by the history of religion and religious studies, theology, sociology and history has to be introduced into the public conscience today. This can promote greater awareness of the contemporary global religious situation and its links with politics and economics and counter rash syntheses such as the ‘clash of civilizations’. This volume is concerned with the connections between religions and the social world and with the extent, limits, and future of secularization. The first part deals with major religious traditions and their explicit or implicit ideas about the individual, social and political order. The second part gives an overview of the religious situation in important geographical areas. Additional contributions analyse the legal organization of the relationship between state and religion in a global perspective and the role of the natural sciences in the process of secularization.
This collection of essays explores the character and quality of the Holocaust's impact and the abiding legacy it has left for social theory. The premise which informs the contributions is that, ten years after its publication, Zygmunt Bauman's claim that social theory has either failed to address the Holocaust or protected itself from its implications remains true.
The debate on varieties of modernity is central to current social theory and research, and this book explores the theme in relation to the culture and society of Turkey. It focuses on the Kemalist project to create a modern Turkish nation-state, analysing its historical background, the role of the concepts of ethnicity and nation, and the configurations of state, society and economy in the new Turkish republic. The author then moves on to examine the relations between Islam and modernity, arguing that both must be understood as open to multiple interpretations rather than seen as monolithic and as diametrically opposed. He considers the rise of Islamism in Turkey and looks in particular at the paradoxical role of women activists within the Islamist movement, ultimately arguing that Islamism must be understood as a modern movement, albeit a paradoxical one, rather than simply as a return to ‘tradition’.
This is a translated edition of five of the nine papers and the responses presented at the first conference of the Deutsche Gesellschaft für Soziologie (DGS) that was held in 1910. These are seminal contributions by some of the founders of classical German sociology and social theory, including Max Weber, Georg Simmel, Ferdinand Tönnies, Ernst Troeltsch and Werner Sombart. A substantial introduction discusses the lives and works of the five thinkers, placing them in the context of Germany in the early twentieth century and discussing their personal and societal connections. The works are a testament to the developing thought of key scholars. The year 1910 was a defining year for German sociology. There were still no sociology schools, departments or even professorships, but a significant number of important thinkers had published crucial sociological works. Through such publications Tönnies, Simmel, Weber, Troeltsch and Sombart had founded considerable reputations, and by 1909 the first three had banded together with other scholars to form the DGS. The works show German sociology at a decisive moment, when these thinkers were at their prime and were engaged in building a new society devoted to investigation of social reality based upon sound scholarly principles and free from biased social dogmatics. The topics continue to have relevance and the exchanges provide a lively dimension, one that is not found simply by reading the books of these five founders of sociological thinking.
This book is a detailed analysis of the attempt by Britain and Spain since 1980 to solve their dispute over the future of Gibraltar. Spain wants the restoration of her territorial integrity, whereas the Gibraltarians have never shown any interest in becoming part of Spain. Britain had ignored UN calls for negotiations, but following the restoration of Spanish democracy and with Spain due to become a fellow member of both NATO and the European Community, Britain felt an obligation to try to resolve the dispute. The book examines the events which have taken place following the signing of the Lisbon Agreement between Britain and Spain to discuss the differences between them on this issue. It traces the effect of the Falklands war in 1982 on the Gibraltar negotiations, and shows that events in the South Atlantic did not prevent an explicit commitment in the Brussels Declaration of 1984 to discuss the thorny issue of the sovereignty of Gibraltar. Since that time, although communications and cooperation between Spain and the Rock have improved, little progress has been made towards resolving the question of sovereignty. | 2019-04-21T22:11:14Z | http://liverpool.universitypressscholarship.com/browse?t1=OSO%3ApoliticalScience |
Totally roarsomel! A simple, stylish and fun tiger enamel pin. The perfect addition to a denim jacket!
The tiger pin has been designed with hard black enamel and finished with gold plating. | 2019-04-18T10:43:20Z | https://www.homebykirsty.com/jewellery/go-get-em-tiger-enamel-pin-badge |
Seventy chamber orchestra students from Tustin Unified School District's Beckman High School performed at the Carnegie Hall on April 10th. Beckman High was one of four Orange County high school music groups scheduled to play on the famed New York stage for the New York International Music Festival at Carnegie Hall.
Red Hill's TrashARTist entry included the artistic reuse of an old patio umbrella transformed into a Monarch butterfly.
Students play in the Tustin Unified basketball festival.
Hundreds of middle school students gathered at Currie Middle School recently for the Tustin Unified Basketball Festival. Teams from each middle school – Columbus Tustin, Currie, Hewes, Orchard Hills, Pioneer and Utt – played basketball all morning, culminating a six-week season. The sixth-, seventh- and eighth-grade teams self-refereed the games. The tournament and after-school sports are sponsored by the Tustin Public Schools Foundation.
Nanette Ehrhard of Currie Middle School organized the tournament, with help from Jillian Rifkin of Orchard Hills.
Red Hill Elementary students took first place for the third year in a row in the MUZEO TrashARTist contest, which challenges students across the county to create art out of trash. Third-, fourth- and fifth-grade students created art for Red Hill’s Learning Garden’s Monarch Waystation, where students plant milkweed to help sustain the Monarch butterfly’s diminishing host plant.
Red Hill’s TrashARTist entry included the artistic reuse of an old patio umbrella transformed into a Monarch butterfly and discarded soap dispensers turned into a caterpillar, among other things. Students worked under the guidance of their teachers, Janelle Crain and Sheryl Harrison, principal Will Neddersen and classroom moms Kerri Wolf and Terri Benedict.
More than 80 entries were submitted by Orange County schools this year. To learn more, visit muzeo.org/trashartist.
The Tustin Unified School District has announced the winners of its Energy Conservation Earth Day Poster Contest in honor of Earth Day.
Each winner will have their poster displayed in the district office board room, receive a $50 gift card and be recognized at the TUSD Board of Education meeting Monday.
Schools throughout the Tustin Unified School District will be celebrating California’s 31st annual “Day of the Teacher” on Wednesday.
“This day has been set aside for students, parents and the community to recognize and appreciate the valuable contributions teachers make to society,” TUSD Superintendent Gregory Franklin said. Many Tustin Unified schools will be holding programs, luncheons and other activities to show their support and appreciation. For more information, call your local school or the TUSD Communications Office at 714- 730-7339. | 2019-04-22T14:16:08Z | https://www.ocregister.com/2013/05/02/school-news-2/ |
The Encore Musical Theatre Company of Dexter has gotten so good at putting on musicals that are tailor made for larger venues that you can’t help but marvel at their success. Now, with their current production of “Mary Poppins”, they have another hit on their hands. So what’s the secret to their success? The answer is that The Encore gives maximum attention to each and every discipline involved in the production of a musical.
Encore’s productions of “My Fair Lady”, “Into the Woods”, and “South Pacific” were extremely popular with audiences and “Mary Poppins” is an excellent choice for December if you don’t want to put on a Christmas show. It’s got a grumpy, disengaged father who finds redemption by story’s end, two disruptive children who do much the same, lots of places where having an imagination is mandatory, and two lead characters who never fail to project good will and positive thinking.
It’s got great songs that come from the solid parentage of Disney Studios and the original Mary Poppins movie. Many of the show’s songs (most written by brothers Richard and Robert Sherman) have become so familiar that children whose parents weren’t even born in 1964 when the movie came out know the lyrics to the best ones by heart. Songs like “Chim Chim Cher-ee”, “A Spoonful of Sugar”, “Let’s Go Fly a Kite”, and “Feed the Birds” have found a permanent place in the American Songbook. And then there’s that song with the one-word 34-letter title, “Supercalifragilisticexpialidocious”. The song, as done in Encore’s production, is, as they say, by itself worth the price of admission. Featuring Mary (Olivia Hernandez), Bert (Sebastian Gerstner), and Mrs. Corry (Kasey Donnelly), as well as many of the Ensemble cast, the number is an imaginative mix of dance, hand jiving, and YMCA hand movements sure to bring smiles and joy.
But what good are great songs without equally great voices to deliver them and here The Encore is flush with talent. Olivia Hernandez as Mary Poppins not only has a wonderful voice and can really turn a song, but her acting talents are just as special. In fact, all the ladies in the production are superb: Ally Kaufmann as Winifred Banks; Amy Dolan-Malaney as Ms. Andrews/Bird Woman; Paige Martin as Neleus; Kasey Donnelly as Mrs. Corry; Wendy Katz Hiller as Mrs. Brill; Kylie Scarpace as Jane’s favorite doll Valentine, Bryana Hall as Miss Lark, Luciana Piazza as Katie Nana, Elizabeth Colson as Annie/Ensemble, and Gayle E. Martin and Jenn Bachman in the Ensemble.
Sebastian Gerstner has a nice go of it as Bert, the happy-go-lucky jack-of-all-trades who’s equally at home drawing chalk pictures on sidewalks or sweeping out the chimneys of London buildings. Gerstner does a nice cockney accent and gives his tap-dancing shoes a workout when he leads the ensemble through a production number done to the tune of “Step in Time”.
Other males in the cast include Daniel A. Helmer as George Banks, Dale Dobson as Admiral Boom and Bank Chairman, Kevin Morgan as Constable/Ensemble, and Nick Casella as John Northbrook/Ensemble. The roles of the two Banks children alternate between three young actors. Jane is played by Dana Steiner, Eva Reed, or Olivia Goosman, Michael by Conner Casey, John Reed, or Emmanuel Morgan.
If any single person deserves the lion’s share of kudos for this ambitious production, it’s director Thalia V. Schramm. From casting to creative to all those unseen little things that you don’t really notice because they’ve all been done right, Ms. Schramm has done a superb job and should be extremely pleased with the results.
The set, designed by Kristin Gribben, looks like it’s freshly emerged from the pages of a pop-up book, with silhouettes of London rooftops filling the background. Movable set pieces create a variety of multi-use steps and platforms, and there are separate areas for the children’s upstairs bedroom and the Banks’ living room. Scene changes and the moving of the set pieces are accomplished quickly and effortlessly, a show in itself done entirely in shadow.
Choreography is by Rachel Constantino and costumes are by Sharon Larkey Urick. Lighting is by Tyler Chinn and sound engineer is Chris Goosman. What would Mary Poppins, or all those other Londoners for that matter, be without their umbrellas, and for keeping track of them and all the other neat props in the show, we’ve Properties Master Anne Donevan to thank. Unfortunately, no flight patterns need to be filed for this Mary Poppins as she does all her maneuvering aided by lighting effects and quick fades.Tyler Driscoll plays keyboards and conducts the other members of the six piece band.
If you’ve only seen musicals at a big box theatre from row “H’ or beyond, and wondered during the show what the faces of the actors actually looked like, go and experience The Encore and their wonderfully entertaining production of “Mary Poppins”. It’s the closest you’ll ever get to feeling like you’re a part of such a large-scale performance.
“Mary Poppins” is a family show… for kids of every age, as the saying goes. The musical is based on the stories of P.L. Travers as well as the Walt Disney film. Encore’s production runs through December 23rd. Tickets are available by calling 1.734.268.6200 or going online at www.theencoretheatre.org/tickets. Be advised that opening weekend was a sellout and tickets may be hard to come by for the remaining run of the show. Encore Musical Theatre is located at 3126 Broad Street in the historic village of Dexter. Take I-94 west and exit at Baker Street. | 2019-04-23T22:19:28Z | https://itsalltheatre.com/2016/12/02/a-supercalifragilisticexpialidocious-mary-poppins-at-encore-musical/ |
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