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88e2e7b91ac5795ec49ed5b89737d72bd227892da774da6a9844ca2a8baf38f3.png
complex
<table><tr><td>Characteristic</td><td></td><td>N = 110</td></tr><tr><td rowspan="2"> Sex </td><td>Male</td><td>60 (54.5%)</td></tr><tr><td>Female</td><td>50 (45.5%)</td></tr><tr><td>Age</td><td>Mean</td><td>60.97 &#177; 2.34</td></tr><tr><td>BMI</td><td>Mean</td><td>27.06 &#177; 0.98</td></tr><tr><td rowspan="4">Ethnicity (skin color)</td><td>Yellow</td><td>6 (6.8%%)</td></tr><tr><td>White</td><td>55 (62.5%)</td></tr><tr><td>Brown</td><td>21 (23.9%)</td></tr><tr><td>Black</td><td>6 (6.8%)</td></tr><tr><td>AKA</td><td> YesNo </td><td> 67 (60.9%)43 (39.1%) </td></tr><tr><td>Smoker</td><td> YesNoEx-smoker </td><td> 61 (55.5%)32 (29.1%)17 (15.5%) </td></tr><tr><td>Diabetes</td><td> YesNo </td><td> 15 (13.6%)95 (86.4%) </td></tr><tr><td>SAH</td><td> YesNo </td><td> 72 (65.5%)38 (34.5%) </td></tr><tr><td>Dyslipidemia</td><td> YesNo </td><td> 46 (58.2%)64 (41.8%) </td></tr><tr><td>Metabolic syndrome</td><td> YesNo </td><td> 25 (22.7%)85 (77.3%) </td></tr><tr><td>Aortic aneurysm</td><td> YesNo </td><td> 42 (38.2%)68 (61.8%) </td></tr><tr><td>Dissection of the aorta</td><td> YesNo </td><td> 14 (12.7%)96 (87.3%) </td></tr><tr><td> Mural thrombus </td><td> YesNo </td><td> 27 (24.5%)83 (75.5%) </td></tr></table>
<table><tr><td>Characteristic</td><td></td><td>N = 110</td></tr><tr><td rowspan="2">Sex</td><td>Male</td><td>60 (54.5%)</td></tr><tr><td>Female</td><td>50 (45.5%)</td></tr><tr><td>Age</td><td>Mean</td><td>60.97 ± 2.34</td></tr><tr><td>BMI</td><td>Mean</td><td>27.06 ± 0.98</td></tr><tr><td>Ethnicity (skin color)</td><td>Yellow</td><td>6 (6.8%%)</td></tr></table>
<table><tr><td>Characteristic</td><td></td><td>N = 110</td></tr><tr><td rowspan="3">Ethnicity (skin color)</td><td>White</td><td>55 (62.5%)</td></tr><tr><td>Brown</td><td>21 (23.9%)</td></tr><tr><td>Black</td><td>6 (6.8%)</td></tr><tr><td>AKA</td><td>YesNo</td><td>67 (60.9%)43 (39.1%)</td></tr><tr><td>Smoker</td><td>YesNoEx-smoker</td><td>61 (55.5%)32 (29.1%)17 (15.5%)</td></tr><tr><td>Diabetes</td><td>YesNo</td><td>15 (13.6%)95 (86.4%)</td></tr><tr><td>SAH</td><td>YesNo</td><td>72 (65.5%)38 (34.5%)</td></tr><tr><td>Dyslipidemia</td><td>YesNo</td><td>46 (58.2%)64 (41.8%)</td></tr><tr><td>Metabolic syndrome</td><td>YesNo</td><td>25 (22.7%)85 (77.3%)</td></tr><tr><td>Aortic aneurysm</td><td>YesNo</td><td>42 (38.2%)68 (61.8%)</td></tr><tr><td>Dissection of the aorta</td><td>YesNo</td><td>14 (12.7%)96 (87.3%)</td></tr><tr><td>Mural thrombus</td><td>YesNo</td><td>27 (24.5%)83 (75.5%)</td></tr></table>
1e1a11aef14334046259aca30b06daff30122621b735cdc5e3fa157a56c82d7f.png
complex
<table><tr><td></td><td colspan="2">Number of</td><td colspan="2">Lower 95% of risk</td></tr><tr><td>Outcome</td><td>Events</td><td>Patients</td><td>rule of 3</td><td>Exact CI</td></tr><tr><td>Epidural haematoma</td><td></td><td></td><td></td><td></td></tr><tr><td>Cardiac</td><td>0</td><td>4971</td><td>1 in 1,700</td><td>1 in 1,350</td></tr><tr><td>Thoracic</td><td>0</td><td>4108</td><td>1 in 1,400</td><td>1 in 1,100</td></tr><tr><td>Vacular</td><td>0</td><td>5026</td><td>1 in 1,700</td><td>1 in 1,350</td></tr><tr><td>Combined</td><td>0</td><td>14105</td><td>1 in 4,700</td><td>1 in 3,800</td></tr><tr><td>Permanent neurological injury</td><td></td><td></td><td></td><td></td></tr><tr><td>Combined</td><td>0</td><td>13827</td><td>1 in 4,600</td><td>1 in 3,750</td></tr></table>
<table><tr><td></td><td colspan="2">Number of</td><td colspan="2">Lower 95% of risk</td></tr><tr><td>Outcome</td><td>Events</td><td>Patients</td><td>rule of 3</td><td>Exact CI</td></tr><tr><td>Epidural haematoma</td><td></td><td></td><td></td><td></td></tr><tr><td>Cardiac</td><td>0</td><td>4971</td><td>1 in 1,700</td><td>1 in 1,350</td></tr><tr><td>Thoracic</td><td>0</td><td>4108</td><td>1 in 1,400</td><td>1 in 1,100</td></tr><tr><td>Vacular</td><td>0</td><td>5026</td><td>1 in 1,700</td><td>1 in 1,350</td></tr><tr><td>Combined</td><td>0</td><td>14105</td><td>1 in 4,700</td><td>1 in 3,800</td></tr><tr><td>Permanent neurological injury</td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td>Combined</td><td>0</td><td>13827</td><td>1 in 4,600</td><td>1 in 3,750</td></tr></table>
d1f9925e6e3b4031c56770baff2bec4514d5dc4f6c3314a601ff7b5e5d64fb48.png
simple
<table><tr><td>Species</td><td>Group</td><td>N<sub>Skull</sub></td><td>N<sub>Mandible</sub></td></tr><tr><td><i>C. australis</i> (aus)</td><td><i>mendocinus</i></td><td>31</td><td>27</td></tr><tr><td><i>C. azarae</i> (aza)</td><td><i>mendocinus</i></td><td>29</td><td>26</td></tr><tr><td><i>C. flamarioni</i> (fla)</td><td><i>mendocinus</i></td><td>32</td><td>22</td></tr><tr><td><i>C. porteousi</i> (por)</td><td><i>mendocinus</i></td><td>30</td><td>28</td></tr><tr><td><i>C. mendocinus</i> (men)</td><td><i>mendocinus</i></td><td>24</td><td>14</td></tr><tr><td><i>C. ibicuiensis</i> (ibi)</td><td><i>torquatus</i></td><td>16</td><td>10</td></tr><tr><td><i>C. lami</i> (lam)</td><td><i>torquatus</i></td><td>89</td><td>66</td></tr><tr><td><i>C. minutus</i> (min)</td><td><i>torquatus</i></td><td>197</td><td>122</td></tr><tr><td><i>C. pearsoni</i> (pea)</td><td><i>torquatus</i></td><td>77</td><td>60</td></tr><tr><td><i>C. perrensi</i> (per)</td><td><i>torquatus</i></td><td>9</td><td>9</td></tr><tr><td><i>C. roigi</i> (roi)</td><td><i>torquatus</i></td><td>7</td><td>7</td></tr><tr><td><i>C. torquatus</i> (tor)</td><td><i>torquatus</i></td><td>222</td><td>124</td></tr><tr><td>Total</td><td></td><td>763</td><td>515</td></tr></table>
<table><tr><td>Species</td><td>Group</td><td>NSkull</td><td>NMandible</td></tr><tr><td>C. australis (aus)</td><td>mendocinus</td><td>31</td><td>27</td></tr><tr><td>C. azarae (aza)</td><td>mendocinus</td><td>29</td><td>26</td></tr><tr><td>C. flamarioni (fla)</td><td>mendocinus</td><td>32</td><td>22</td></tr><tr><td>C. porteousi (por)</td><td>mendocinus</td><td>30</td><td>28</td></tr><tr><td>C. mendocinus (men)</td><td>mendocinus</td><td>24</td><td>14</td></tr></table>
<table><tr><td>Species</td><td>Group</td><td>NSkull</td><td>NMandible</td></tr><tr><td>C. ibicuiensis (ibi)</td><td>torquatus</td><td>16</td><td>10</td></tr><tr><td>C. lami (lam)</td><td>torquatus</td><td>89</td><td>66</td></tr><tr><td>C. minutus (min)</td><td>torquatus</td><td>197</td><td>122</td></tr><tr><td>C. pearsoni (pea)</td><td>torquatus</td><td>77</td><td>60</td></tr><tr><td>C. perrensi (per)</td><td>torquatus</td><td>9</td><td>9</td></tr><tr><td>C. roigi (roi)</td><td>torquatus</td><td>7</td><td>7</td></tr><tr><td>C. torquatus (tor)</td><td>torquatus</td><td>222</td><td>124</td></tr><tr><td>Total</td><td></td><td>763</td><td>515</td></tr></table>
79ef7d1078cabfe0e6206a4b58c2700dd48086f132fe29c246cbe6e477d8f1aa.png
complex
<table><tr><td></td><td></td><td colspan="6">Percentile</td></tr><tr><td>Sample</td><td>No. &gt; LOD/total (%)a</td><td>10th</td><td>25th</td><td>50th</td><td>75th</td><td>90th</td><td>95th</td></tr><tr><td>Maternal blood (pg/g)a</td><td>13/92 (14)</td><td>&lt; LOD</td><td>&lt; LOD</td><td>&lt; LOD</td><td>&lt; LOD</td><td>1.5</td><td>2.5</td></tr><tr><td>Umbilical cord blood (pg/g)a</td><td>8/65 (12)</td><td>&lt; LOD</td><td>&lt; LOD</td><td>&lt; LOD</td><td>&lt; LOD</td><td>2.3</td><td>2.5</td></tr><tr><td>Postpartum meconium (ng/g)b</td><td>23/83 (28)</td><td>&lt; LOD</td><td>&lt; LOD</td><td>&lt; LOD</td><td>0.44</td><td>0.62</td><td>0.77</td></tr></table>
<table><tr><td></td><td></td><td colspan="6">Percentile</td></tr><tr><td>Sample</td><td>No. > LOD/total (%)a</td><td>10th</td><td>25th</td><td>50th</td><td>75th</td><td>90th</td><td>95th</td></tr></table>
<table><tr><td>Maternal blood (pg/g)a</td><td>13/92 (14)</td><td>< LOD</td><td>< LOD</td><td>< LOD</td><td>< LOD</td><td>1.5</td><td>2.5</td></tr><tr><td>Umbilical cord blood (pg/g)a</td><td>8/65 (12)</td><td>< LOD</td><td>< LOD</td><td>< LOD</td><td>< LOD</td><td>2.3</td><td>2.5</td></tr><tr><td>Postpartum meconium (ng/g)b</td><td>23/83 (28)</td><td>< LOD</td><td>< LOD</td><td>< LOD</td><td>0.44</td><td>0.62</td><td>0.77</td></tr></table>
4780c8032c188c3eea1798f4d63c399155352e8ba270d3fb23fa8483504aedf9.png
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<table><tr><td>Sub-county</td><td>Year</td><td>Monthly target<sup>a</sup></td><td>Yearly target<sup>b</sup></td><td>No. of dose 1<sup>c</sup></td><td>% coverage for dose 1</td><td>No. of dose 2<sup>d</sup></td><td>% coverage for dose 2</td><td>Dropout (%)</td></tr><tr><td rowspan="4">Kiambu</td><td>2014</td><td>285</td><td>1425</td><td>1530</td><td>107.4</td><td>1174</td><td>82.4</td><td>23.3</td></tr><tr><td>2015</td><td>285</td><td>3420</td><td>4351</td><td>127.2</td><td>3977</td><td>116.3</td><td>8.6</td></tr><tr><td>2016</td><td>295</td><td>1180</td><td>1613</td><td>136.7</td><td>1467</td><td>124.3</td><td>9.1</td></tr><tr><td>Total</td><td></td><td>6025</td><td>7494</td><td>124.4</td><td>6618</td><td>109.8</td><td>11.7</td></tr><tr><td rowspan="4">Mbita</td><td>2014</td><td>402</td><td>2010</td><td>1096</td><td>54.5</td><td>667</td><td>33.2</td><td>39.1</td></tr><tr><td>2015</td><td>414</td><td>4968</td><td>3821</td><td>76.9</td><td>3348</td><td>67.4</td><td>12.4</td></tr><tr><td>2016</td><td>426</td><td>1704</td><td>1327</td><td>77.9</td><td>1156</td><td>67.8</td><td>12.9</td></tr><tr><td>Total</td><td></td><td>8682</td><td>6244</td><td>71.9</td><td>5171</td><td>59.6</td><td>17.1</td></tr></table>
<table><tr><td>Sub-county</td><td>Year</td><td>Monthly targeta</td><td>Yearly targetb</td></tr><tr><td rowspan="4">Kiambu</td><td>2014</td><td>285</td><td>1425</td></tr><tr><td>2015</td><td>285</td><td>3420</td></tr><tr><td>2016</td><td>295</td><td>1180</td></tr><tr><td>Total</td><td></td><td>6025</td></tr><tr><td rowspan="4">Mbita</td><td>2014</td><td>402</td><td>2010</td></tr><tr><td>2015</td><td>414</td><td>4968</td></tr><tr><td>2016</td><td>426</td><td>1704</td></tr><tr><td>Total</td><td></td><td>8682</td></tr></table>
<table><tr><td>No. of dose 1c</td><td>% coverage for dose 1</td><td>No. of dose 2d</td><td>% coverage for dose 2</td><td>Dropout (%)</td></tr><tr><td>1530</td><td>107.4</td><td>1174</td><td>82.4</td><td>23.3</td></tr><tr><td>4351</td><td>127.2</td><td>3977</td><td>116.3</td><td>8.6</td></tr><tr><td>1613</td><td>136.7</td><td>1467</td><td>124.3</td><td>9.1</td></tr><tr><td>7494</td><td>124.4</td><td>6618</td><td>109.8</td><td>11.7</td></tr><tr><td>1096</td><td>54.5</td><td>667</td><td>33.2</td><td>39.1</td></tr><tr><td>3821</td><td>76.9</td><td>3348</td><td>67.4</td><td>12.4</td></tr><tr><td>1327</td><td>77.9</td><td>1156</td><td>67.8</td><td>12.9</td></tr><tr><td>6244</td><td>71.9</td><td>5171</td><td>59.6</td><td>17.1</td></tr></table>
5ed6ff0c5115205fbd08f7b90b40000d5a1052dec405e6eea4a5ad0db54cd410.png
simple
<table><tr><td><i>Case</i></td><td><i>MP Pulse Therapy</i></td><td><i>Prednisone</i></td><td><i>Others</i></td><td><i>Proteinuria (month)</i></td><td><i>Outcome</i></td></tr><tr><td>1</td><td></td><td>+</td><td>MMF</td><td>7</td><td>RBC, 14/HP after 15 months</td></tr><tr><td>2</td><td></td><td></td><td>Tripterygium</td><td>2</td><td>Normal urine test after 13 months</td></tr><tr><td>3</td><td></td><td>+</td><td>MMF</td><td>4</td><td>RBC, 14/HP after 20 months</td></tr><tr><td>4</td><td>+</td><td>+</td><td>CTX</td><td>5</td><td>Normal urine test after 17 months</td></tr><tr><td>5</td><td></td><td>+</td><td>Tripterygium</td><td>1</td><td>Normal urine test after 7 months</td></tr><tr><td>6</td><td>+</td><td>+</td><td>CTX</td><td>5</td><td>RBC, 10/HP after 15 months</td></tr><tr><td>7</td><td></td><td>+</td><td></td><td>4</td><td>RBC, 8/HP after 19 months</td></tr><tr><td>8</td><td></td><td>+</td><td>Tripterygium</td><td>2</td><td>RBC, 6/HP after 17 months</td></tr><tr><td>9</td><td></td><td></td><td>Tripterygium</td><td>4</td><td>Normal urine test after 13 months</td></tr><tr><td>10</td><td>+</td><td>+</td><td>CTX</td><td>4</td><td>Normal urine test after 15 months</td></tr><tr><td>11</td><td></td><td>+</td><td>MMF</td><td>4</td><td>RBC, 15/HP after 13 months</td></tr></table>
<table><tr><td>Case</td><td>MP Pulse Therapy</td><td>Prednisone</td><td>Others</td><td>Proteinuria (month)</td><td>Outcome</td></tr><tr><td>1</td><td></td><td>+</td><td>MMF</td><td>7</td><td>RBC, 14/HP after 15 months</td></tr><tr><td>2</td><td></td><td></td><td>Tripterygium</td><td>2</td><td>Normal urine test after 13 months</td></tr><tr><td>3</td><td></td><td>+</td><td>MMF</td><td>4</td><td>RBC, 14/HP after 20 months</td></tr><tr><td>4</td><td>+</td><td>+</td><td>CTX</td><td>5</td><td>Normal urine test after 17 months</td></tr><tr><td>5</td><td></td><td>+</td><td>Tripterygium</td><td>1</td><td>Normal urine test after 7 months</td></tr><tr><td>6</td><td>+</td><td>+</td><td>CTX</td><td>5</td><td>RBC, 10/HP after 15 months</td></tr></table>
<table><tr><td>7</td><td></td><td>+</td><td></td><td>4</td><td>RBC, 8/HP after 19 months</td></tr><tr><td>8</td><td></td><td>+</td><td>Tripterygium</td><td>2</td><td>RBC, 6/HP after 17 months</td></tr><tr><td>9</td><td></td><td></td><td>Tripterygium</td><td>4</td><td>Normal urine test after 13 months</td></tr><tr><td>10</td><td>+</td><td>+</td><td>CTX</td><td>4</td><td>Normal urine test after 15 months</td></tr><tr><td>11</td><td></td><td>+</td><td>MMF</td><td>4</td><td>RBC, 15/HP after 13 months</td></tr></table>
870f5e89249ba0705c534723f97f28cf0d83c27cccea6a6bbd6081d64352041c.png
complex
<table><tr><td rowspan="2"> </td><td colspan="4">Hyperhomocysteinemia<sup>a</sup></td><td colspan="4">Hypercysteinemia<sup>a</sup></td></tr><tr><td>Q1</td><td>Q2</td><td>Q3</td><td>Q4</td><td>Q1</td><td>Q2</td><td>Q3</td><td>Q4</td></tr><tr><td><i>n</i></td><td>253</td><td>254</td><td>254</td><td>254</td><td>253</td><td>254</td><td>254</td><td>254</td></tr><tr><td>Total protein intake</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Crude OR (95% CI)<sup>b</sup></td><td>1</td><td>1.20(0.84-1.71)</td><td>1.30(0.91-1.85)</td><td>1.94(1.36-2.77)<sup>**</sup></td><td>1</td><td>1.20(0.70-2.06)</td><td>1.60(0.96-2.68)</td><td>1.78(1.07-2.96)<sup>*</sup></td></tr><tr><td>Adjusted OR (95% CI)<sup>c</sup></td><td>1</td><td>1.30(0.89-1.91)</td><td>1.37(0.94-1.99)</td><td>2.13(1.45-3.12)<sup>**</sup></td><td>1</td><td>1.16(0.66-2.04)</td><td>1.67(0.97-2.86)</td><td>1.73(1.03-2.92)<sup>*</sup></td></tr><tr><td>Adjusted OR (95% CI)<sup>d</sup></td><td>1</td><td>1.48(0.98-2.25)</td><td>1.57(1.02-2.41)<sup>*</sup></td><td>2.63(1.70-4.07)<sup>**</sup></td><td>1</td><td>1.14(0.64-2.03)</td><td>1.56(0.89-2.75)</td><td>1.69(1.02-2.87)<sup>*</sup></td></tr><tr><td>Animal protein intake</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Crude OR (95% CI)<sup>b</sup></td><td>1</td><td>1.46(1.01-2.10)<sup>*</sup></td><td>1.79(1.25-2.58)<sup>*</sup></td><td>3.32(2.30-4.79)<sup>**</sup></td><td>1</td><td>1.27(0.76-2.13)</td><td>1.34(0.80-2.24)</td><td>1.50(0.91-2.49)</td></tr><tr><td>Adjusted OR (95% CI)<sup>c</sup></td><td>1</td><td>1.51(1.03-2.22)<sup>*</sup></td><td>1.87(1.27-2.75)<sup>*</sup></td><td>3.73(2.52-5.54)<sup>**</sup></td><td>1</td><td>1.28(0.74-2.21)</td><td>1.45(0.84-2.51)</td><td>1.59(0.93-2.70)</td></tr><tr><td>Adjusted OR (95% CI)<sup>d</sup></td><td>1</td><td>1.56(1.03-2.38)<sup>*</sup></td><td>2.01(1.31-3.08)<sup>*</sup></td><td>4.14(2.67-6.43)<sup>**</sup></td><td>1</td><td>1.34(0.77-2.36)</td><td>1.51(0.85-2.68)</td><td>1.60(0.91-2.80)</td></tr><tr><td>Plant protein intake</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Crude OR (95% CI)<sup>b</sup></td><td>1</td><td>0.77(0.54-1.10)</td><td>0.51(0.35-0.72)<sup>**</sup></td><td>0.46(0.32-0.66) <sup>**</sup></td><td>1</td><td>1.01(0.62-1.62)</td><td>0.91(0.55-1.48)</td><td>0.88(0.53-1.44)</td></tr><tr><td>Adjusted OR (95% CI)<sup>c</sup></td><td>1</td><td>0.77(0.53-1.10)</td><td>0.54(0.37-0.79)<sup>*</sup></td><td>0.47(0.32-0.68)<sup>**</sup></td><td>1</td><td>1.11(0.66-1.86)</td><td>1.02(0.61-1.70)</td><td>0.90(0.53-1.51)</td></tr><tr><td>Adjusted OR (95% CI)<sup>d</sup></td><td>1</td><td>0.76(0.51-1.13)</td><td>0.63(0.41-0.96)<sup>*</sup></td><td>0.59(0.38-0.91)<sup>*</sup></td><td>1</td><td>1.28(0.73-2.26)</td><td>1.12(0.64-1.93)</td><td>0.96(0.56-1.64)</td></tr></table>
<table><tr><td rowspan="2"></td><td colspan="4">Hyperhomocysteinemiaa</td><td colspan="4">Hypercysteinemiaa</td></tr><tr><td>Q1</td><td>Q2</td><td>Q3</td><td>Q4</td><td>Q1</td><td>Q2</td><td>Q3</td><td>Q4</td></tr></table>
<table><tr><td>n</td><td>253</td><td>254</td><td>254</td><td>254</td><td>253</td><td>254</td><td>254</td><td>254</td></tr><tr><td>Total protein intake</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Crude OR (95% CI)b</td><td>1</td><td>1.20(0.84-1.71)</td><td>1.30(0.91-1.85)</td><td>1.94(1.36-2.77)**</td><td>1</td><td>1.20(0.70-2.06)</td><td>1.60(0.96-2.68)</td><td>1.78(1.07-2.96)*</td></tr><tr><td>Adjusted OR (95% CI)c</td><td>1</td><td>1.30(0.89-1.91)</td><td>1.37(0.94-1.99)</td><td>2.13(1.45-3.12)**</td><td>1</td><td>1.16(0.66-2.04)</td><td>1.67(0.97-2.86)</td><td>1.73(1.03-2.92)*</td></tr><tr><td>Adjusted OR (95% CI)d</td><td>1</td><td>1.48(0.98-2.25)</td><td>1.57(1.02-2.41)*</td><td>2.63(1.70-4.07)**</td><td>1</td><td>1.14(0.64-2.03)</td><td>1.56(0.89-2.75)</td><td>1.69(1.02-2.87)*</td></tr><tr><td>Animal protein intake</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Crude OR (95% CI)b</td><td>1</td><td>1.46(1.01-2.10)*</td><td>1.79(1.25-2.58)*</td><td>3.32(2.30-4.79)**</td><td>1</td><td>1.27(0.76-2.13)</td><td>1.34(0.80-2.24)</td><td>1.50(0.91-2.49)</td></tr><tr><td>Adjusted OR (95% CI)c</td><td>1</td><td>1.51(1.03-2.22)*</td><td>1.87(1.27-2.75)*</td><td>3.73(2.52-5.54)**</td><td>1</td><td>1.28(0.74-2.21)</td><td>1.45(0.84-2.51)</td><td>1.59(0.93-2.70)</td></tr><tr><td>Adjusted OR (95% CI)d</td><td>1</td><td>1.56(1.03-2.38)*</td><td>2.01(1.31-3.08)*</td><td>4.14(2.67-6.43)**</td><td>1</td><td>1.34(0.77-2.36)</td><td>1.51(0.85-2.68)</td><td>1.60(0.91-2.80)</td></tr><tr><td>Plant protein intake</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Crude OR (95% CI)b</td><td>1</td><td>0.77(0.54-1.10)</td><td>0.51(0.35-0.72)**</td><td>0.46(0.32-0.66) **</td><td>1</td><td>1.01(0.62-1.62)</td><td>0.91(0.55-1.48)</td><td>0.88(0.53-1.44)</td></tr><tr><td>Adjusted OR (95% CI)c</td><td>1</td><td>0.77(0.53-1.10)</td><td>0.54(0.37-0.79)*</td><td>0.47(0.32-0.68)**</td><td>1</td><td>1.11(0.66-1.86)</td><td>1.02(0.61-1.70)</td><td>0.90(0.53-1.51)</td></tr><tr><td>Adjusted OR (95% CI)d</td><td>1</td><td>0.76(0.51-1.13)</td><td>0.63(0.41-0.96)*</td><td>0.59(0.38-0.91)*</td><td>1</td><td>1.28(0.73-2.26)</td><td>1.12(0.64-1.93)</td><td>0.96(0.56-1.64)</td></tr></table>
7695904add8ea3430ec56beb3c10043a5068dfb97b223e6a544e93ac0f2293e4.png
simple
<table><tr><td>Variable</td><td>No.</td><td>IR<sup>a </sup>(95% CI)</td><td>Unadjusted IRR (95% CI)</td><td>Adjusted IRR<sup>b </sup>(95% CI)<sup>b</sup></td><td>P<sup>c</sup></td></tr><tr><td>Total</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Controls</td><td>798</td><td>40.8 (38.1-43.7)</td><td>1(reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>ESRD</td><td>62</td><td>102 (79.5-131)</td><td>2.50 (1.93-3.24)</td><td>2.41 (1.83-3.16)</td><td>&lt;0.001</td></tr><tr><td>Sex Controls</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Men</td><td>404</td><td>33.9 (30.8-37.4)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>Women</td><td>394</td><td>51.5 (46.7-56.9)</td><td>1.52 (1.32-1.75)</td><td>1.54 (1.34-1.77)</td><td>&lt;0.001</td></tr><tr><td>ESRD</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Men</td><td>27</td><td>71.3 (48.9-104)</td><td>1</td><td>1</td><td>-</td></tr><tr><td>Women</td><td>35</td><td>153 (110&#8211;213)</td><td>2.14 (1.30-3.54)</td><td>2.11 (1.27-3.48)</td><td>0.004</td></tr><tr><td>Age (years) Controls</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>14-49</td><td>83</td><td>18.8 (15.2-23.3)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>50-64</td><td>242</td><td>40.2 (35.5-45.7)</td><td>2.14 (1.67-2.75)</td><td>2.11 (1.64-2.71)</td><td>&lt;0.001</td></tr><tr><td>&#8805; 65</td><td>473</td><td>51.8 (47.3-56.7)</td><td>2.75 (2.18-3.48)</td><td>2.51 (1.98-3.18)</td><td>&lt;0.001</td></tr><tr><td>ESRD</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>14-49</td><td>15</td><td>73.0 (44.0-121)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>50-64</td><td>34</td><td>165 (118&#8211;231)</td><td>2.26 (1.23-4.15)</td><td>2.39 (1.30-4.39)</td><td>0.005</td></tr><tr><td>&#8805; 65</td><td>13</td><td>66.0 (38.3-114)</td><td>0.90 (0.43-1.90)</td><td>1.03 (0.48-2.19)</td><td>0.9</td></tr><tr><td>Comorbidity level <sup>d</sup> Controls</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Low</td><td>591</td><td>36.8 (34.0-39.9)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>Medium</td><td>152</td><td>52.1 (44.4-61.1)</td><td>1.41 (1.18-1.69)</td><td>1.23 (1.02-1.47)</td><td>0.03</td></tr><tr><td>High</td><td>55</td><td>91.7 (70.4-119)</td><td>2.49 (1.89-3.28)</td><td>2.12 (1.60-2.81)</td><td>&lt;0.001</td></tr><tr><td>ESRD</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Low</td><td>40</td><td>130 (95.1-177)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>Medium</td><td>15</td><td>98.4 (59.3-163)</td><td>0.76 (0.42-1.37)</td><td>0.77 (0.42-1.41)</td><td>0.4</td></tr><tr><td>High</td><td>7</td><td>47.5 (22.6-99.6)</td><td>0.37 (0.16-0.82)</td><td>0.39 (0.17-0.87)</td><td>0.02</td></tr></table>
<table><tr><td>Variable</td><td>No.</td><td>IRa (95% CI)</td><td>Unadjusted IRR (95% CI)</td><td>Adjusted IRRb (95% CI)b</td><td>Pc</td></tr><tr><td>Total</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Controls</td><td>798</td><td>40.8 (38.1-43.7)</td><td>1(reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>ESRD</td><td>62</td><td>102 (79.5-131)</td><td>2.50 (1.93-3.24)</td><td>2.41 (1.83-3.16)</td><td><0.001</td></tr><tr><td>Sex Controls</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Men</td><td>404</td><td>33.9 (30.8-37.4)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>Women</td><td>394</td><td>51.5 (46.7-56.9)</td><td>1.52 (1.32-1.75)</td><td>1.54 (1.34-1.77)</td><td><0.001</td></tr><tr><td>ESRD</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Men</td><td>27</td><td>71.3 (48.9-104)</td><td>1</td><td>1</td><td>-</td></tr><tr><td>Women</td><td>35</td><td>153 (110–213)</td><td>2.14 (1.30-3.54)</td><td>2.11 (1.27-3.48)</td><td>0.004</td></tr><tr><td>Age (years) Controls</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>14-49</td><td>83</td><td>18.8 (15.2-23.3)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>50-64</td><td>242</td><td>40.2 (35.5-45.7)</td><td>2.14 (1.67-2.75)</td><td>2.11 (1.64-2.71)</td><td><0.001</td></tr><tr><td>≥ 65</td><td>473</td><td>51.8 (47.3-56.7)</td><td>2.75 (2.18-3.48)</td><td>2.51 (1.98-3.18)</td><td><0.001</td></tr><tr><td>ESRD</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>14-49</td><td>15</td><td>73.0 (44.0-121)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>50-64</td><td>34</td><td>165 (118–231)</td><td>2.26 (1.23-4.15)</td><td>2.39 (1.30-4.39)</td><td>0.005</td></tr><tr><td>≥ 65</td><td>13</td><td>66.0 (38.3-114)</td><td>0.90 (0.43-1.90)</td><td>1.03 (0.48-2.19)</td><td>0.9</td></tr><tr><td>Comorbidity level d Controls</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Low</td><td>591</td><td>36.8 (34.0-39.9)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>Medium</td><td>152</td><td>52.1 (44.4-61.1)</td><td>1.41 (1.18-1.69)</td><td>1.23 (1.02-1.47)</td><td>0.03</td></tr></table>
<table><tr><td>Variable</td><td>No.</td><td>IRa (95% CI)</td><td>Unadjusted IRR (95% CI)</td><td>Adjusted IRRb (95% CI)b</td><td>Pc</td></tr><tr><td>High</td><td>55</td><td>91.7 (70.4-119)</td><td>2.49 (1.89-3.28)</td><td>2.12 (1.60-2.81)</td><td><0.001</td></tr><tr><td>ESRD</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Low</td><td>40</td><td>130 (95.1-177)</td><td>1 (reference)</td><td>1 (reference)</td><td>-</td></tr><tr><td>Medium</td><td>15</td><td>98.4 (59.3-163)</td><td>0.76 (0.42-1.37)</td><td>0.77 (0.42-1.41)</td><td>0.4</td></tr><tr><td>High</td><td>7</td><td>47.5 (22.6-99.6)</td><td>0.37 (0.16-0.82)</td><td>0.39 (0.17-0.87)</td><td>0.02</td></tr></table>
3bcc14848e733fa1b0decee065d9db34ca1076793b785c269196e8ca7c950d33.png
simple
<table><tr><td>Approaches</td><td># of selected nodes</td><td># of Sampled records</td><td>Recall (%)</td><td>Precision (%)</td></tr><tr><td>hLDA</td><td>20</td><td>200</td><td>48.2</td><td>76.5</td></tr><tr><td>Ours without domain knowledge</td><td>20</td><td>200</td><td>61.7</td><td>82.56</td></tr><tr><td>Ours with domain knowledge</td><td>20</td><td>200</td><td>65.86</td><td>82.33</td></tr></table>
<table><tr><td>Approaches</td><td># of selected nodes</td><td># of Sampled records</td><td>Recall (%)</td><td>Precision (%)</td></tr><tr><td>hLDA</td><td>20</td><td>200</td><td>48.2</td><td>76.5</td></tr><tr><td>Ours without domain knowledge</td><td>20</td><td>200</td><td>61.7</td><td>82.56</td></tr></table>
<table><tr><td>Ours with domain knowledge</td><td>20</td><td>200</td><td>65.86</td><td>82.33</td></tr></table>
4d4a36077150ed0e9bf8b46edb06f2f7c9b978f14e7ef7239203a0c88e31b5df.png
complex
<table><tr><td>Male/female</td><td>21/4</td></tr><tr><td>Injured side</td><td></td></tr><tr><td>Right/left</td><td>18/7</td></tr><tr><td>Dominance</td><td></td></tr><tr><td>Right/left</td><td>21/4</td></tr><tr><td colspan="2">Mechanism of primary injury</td></tr><tr><td>Bicycling</td><td>9</td></tr><tr><td>Simple fall</td><td>7</td></tr><tr><td>Sport</td><td>7</td></tr><tr><td>Traffic accident</td><td>2</td></tr><tr><td colspan="2">Rockwood type in primary radiographs</td></tr><tr><td>II</td><td>3</td></tr><tr><td>III</td><td>6</td></tr><tr><td>IV</td><td>1</td></tr><tr><td>V</td><td>15</td></tr><tr><td>Mean age at time of injury, y (range)</td><td>44 (22&#8211;59)</td></tr><tr><td>Mean age at time of examination, y (range)</td><td>48 (24&#8211;63)</td></tr></table>
<table><tr><td>Male/female</td><td>21/4</td></tr><tr><td>Injured side</td><td></td></tr><tr><td>Right/left</td><td>18/7</td></tr><tr><td>Dominance</td><td></td></tr><tr><td>Right/left</td><td>21/4</td></tr><tr><td colspan="2">Mechanism of primary injury</td></tr></table>
<table><tr><td>Bicycling</td><td>9</td></tr><tr><td>Simple fall</td><td>7</td></tr><tr><td>Sport</td><td>7</td></tr><tr><td>Traffic accident</td><td>2</td></tr><tr><td colspan="2">Rockwood type in primary radiographs</td></tr><tr><td>II</td><td>3</td></tr><tr><td>III</td><td>6</td></tr><tr><td>IV</td><td>1</td></tr><tr><td>V</td><td>15</td></tr><tr><td>Mean age at time of injury, y (range)</td><td>44 (22–59)</td></tr><tr><td>Mean age at time of examination, y (range)</td><td>48 (24–63)</td></tr></table>
47a4ff060bdf04c685fe12d7ab674e40153b298bab303303fe75392352bdb339.png
simple
<table><tr><td>Variables</td><td>Sample Number (Persons)</td><td>Weighted Number (Million Persons)</td><td>Proportion (%)</td></tr><tr><td>Total</td><td>1,909,199</td><td>985</td><td>100</td></tr><tr><td>Age group (years)</td><td></td><td></td><td></td></tr><tr><td>18&#8211;39</td><td>822,041</td><td>423</td><td>42.95</td></tr><tr><td>40&#8211;64</td><td>836,406</td><td>432</td><td>43.84</td></tr><tr><td>65+</td><td>250,752</td><td>130</td><td>13.21</td></tr><tr><td>Gender</td><td></td><td></td><td></td></tr><tr><td>Male</td><td>949,955</td><td>490</td><td>49.74</td></tr><tr><td>Female</td><td>959,244</td><td>495</td><td>50.26</td></tr><tr><td>Illiterate</td><td></td><td></td><td></td></tr><tr><td>Yes</td><td>302,635</td><td>160</td><td>16.25</td></tr><tr><td>No</td><td>1,606,564</td><td>825</td><td>83.75</td></tr><tr><td>Residence</td><td></td><td></td><td></td></tr><tr><td>Rural</td><td>1,229,862</td><td>665</td><td>67.57</td></tr><tr><td>Urban</td><td>679,337</td><td>319</td><td>32.43</td></tr><tr><td>Region</td><td></td><td></td><td></td></tr><tr><td>East</td><td>769,169</td><td>401</td><td>40.73</td></tr><tr><td>Central</td><td>558,169</td><td>317</td><td>32.2</td></tr><tr><td>West</td><td>581,861</td><td>267</td><td>27.07</td></tr><tr><td>Marital status</td><td></td><td></td><td></td></tr><tr><td>Unmarried</td><td>227,393</td><td>115</td><td>11.66</td></tr><tr><td>Married</td><td>1,523,107</td><td>788</td><td>80.03</td></tr><tr><td>Divorced or widowed</td><td>158,699</td><td>82</td><td>8.31</td></tr><tr><td>Employment</td><td></td><td></td><td></td></tr><tr><td>Yes</td><td>1,367,709</td><td>719</td><td>72.99</td></tr><tr><td>No</td><td>541,490</td><td>266</td><td>27.01</td></tr><tr><td>Annual family income per capita by residential area *</td><td></td><td></td><td></td></tr><tr><td>&gt;national average</td><td>462,517</td><td>233</td><td>23.69</td></tr><tr><td>&#8804;national average</td><td>1,446,682</td><td>751</td><td>76.31</td></tr></table>
<table><tr><td>Variables</td><td>Sample Number (Persons)</td><td>Weighted Number (Million Persons)</td><td>Proportion (%)</td></tr><tr><td>Total</td><td>1,909,199</td><td>985</td><td>100</td></tr><tr><td>Age group (years)</td><td></td><td></td><td></td></tr><tr><td>18–39</td><td>822,041</td><td>423</td><td>42.95</td></tr><tr><td>40–64</td><td>836,406</td><td>432</td><td>43.84</td></tr><tr><td>65+</td><td>250,752</td><td>130</td><td>13.21</td></tr><tr><td>Gender</td><td></td><td></td><td></td></tr><tr><td>Male</td><td>949,955</td><td>490</td><td>49.74</td></tr><tr><td>Female</td><td>959,244</td><td>495</td><td>50.26</td></tr><tr><td>Illiterate</td><td></td><td></td><td></td></tr><tr><td>Yes</td><td>302,635</td><td>160</td><td>16.25</td></tr><tr><td>No</td><td>1,606,564</td><td>825</td><td>83.75</td></tr><tr><td>Residence</td><td></td><td></td><td></td></tr><tr><td>Rural</td><td>1,229,862</td><td>665</td><td>67.57</td></tr><tr><td>Urban</td><td>679,337</td><td>319</td><td>32.43</td></tr></table>
<table><tr><td>Variables</td><td>Sample Number (Persons)</td><td>Weighted Number (Million Persons)</td><td>Proportion (%)</td></tr><tr><td>Region</td><td></td><td></td><td></td></tr><tr><td>East</td><td>769,169</td><td>401</td><td>40.73</td></tr><tr><td>Central</td><td>558,169</td><td>317</td><td>32.2</td></tr><tr><td>West</td><td>581,861</td><td>267</td><td>27.07</td></tr><tr><td>Marital status</td><td></td><td></td><td></td></tr><tr><td>Unmarried</td><td>227,393</td><td>115</td><td>11.66</td></tr><tr><td>Married</td><td>1,523,107</td><td>788</td><td>80.03</td></tr><tr><td>Divorced or widowed</td><td>158,699</td><td>82</td><td>8.31</td></tr><tr><td>Employment</td><td></td><td></td><td></td></tr><tr><td>Yes</td><td>1,367,709</td><td>719</td><td>72.99</td></tr><tr><td>No</td><td>541,490</td><td>266</td><td>27.01</td></tr><tr><td>Annual family income per capita by residential area *</td><td></td><td></td><td></td></tr><tr><td>>national average</td><td>462,517</td><td>233</td><td>23.69</td></tr><tr><td>≤national average</td><td>1,446,682</td><td>751</td><td>76.31</td></tr></table>
e9a9f0ba75aea6dff970daced9c8dfb2113378efcf4479cce9c4147012b2edc5.png
complex
<table><tr><td rowspan="3">Predictive variables</td><td colspan="3">Dependent variable LDL score*</td></tr><tr><td rowspan="2"><i>p</i></td><td rowspan="2">OR</td><td>95.0% CI for OR</td></tr><tr><td>lower&#8211;upper</td></tr><tr><td>WC (1)</td><td>0.029</td><td>1.80</td><td>1.06&#8211;3.05</td></tr><tr><td>Age (2)</td><td>0.935</td><td>0.93</td><td>0.97&#8211;1.03</td></tr><tr><td>WC (1)</td><td>0.091</td><td>1.60</td><td>0.92&#8211;2.76</td></tr><tr><td>Age (2)</td><td>0.853</td><td>0.99</td><td>0.96&#8211;1.03</td></tr><tr><td>Apo B (2)</td><td>0.001</td><td>9.90</td><td>2.64&#8211;37.10</td></tr><tr><td>WC (1)</td><td>0.525</td><td>1.21</td><td>0.67&#8211;2.18</td></tr><tr><td>Age (2)</td><td>0.352</td><td>0.98</td><td>0.94&#8211;1.01</td></tr><tr><td>Apo B (2)</td><td>0.124</td><td>3.20</td><td>0.72&#8211;14.12</td></tr><tr><td>Triglycerides (2)</td><td>&lt;0.001</td><td>1.01</td><td>1.00&#8211;1.02</td></tr></table>
<table><tr><td rowspan="3">Predictive variables</td></tr><tr></tr><tr></tr><tr><td>WC (1)</td></tr><tr><td>Age (2)</td></tr><tr><td>WC (1)</td></tr><tr><td>Age (2)</td></tr><tr><td>Apo B (2)</td></tr><tr><td>WC (1)</td></tr><tr><td>Age (2)</td></tr><tr><td>Apo B (2)</td></tr><tr><td>Triglycerides (2)</td></tr></table>
<table><tr><td colspan="3">Dependent variable LDL score*</td></tr><tr><td rowspan="2">p</td><td rowspan="2">OR</td><td>95.0% CI for OR</td></tr><tr><td>lower–upper</td></tr><tr><td>0.029</td><td>1.80</td><td>1.06–3.05</td></tr><tr><td>0.935</td><td>0.93</td><td>0.97–1.03</td></tr><tr><td>0.091</td><td>1.60</td><td>0.92–2.76</td></tr><tr><td>0.853</td><td>0.99</td><td>0.96–1.03</td></tr><tr><td>0.001</td><td>9.90</td><td>2.64–37.10</td></tr><tr><td>0.525</td><td>1.21</td><td>0.67–2.18</td></tr><tr><td>0.352</td><td>0.98</td><td>0.94–1.01</td></tr><tr><td>0.124</td><td>3.20</td><td>0.72–14.12</td></tr><tr><td><0.001</td><td>1.01</td><td>1.00–1.02</td></tr></table>
2f538e1f8e235b8b48db35ce0669d1c0fd61eb78751d848ade9588dbf8d649da.png
simple
<table><tr><td>Level of consciousness</td><td>Example of positive collective values</td></tr><tr><td>7. Service: Self-less service to the world</td><td>Social responsibility, future generations, long-term perspective, ethics, compassion, humility</td></tr><tr><td>6. Making a difference: to the local community or health district</td><td>Collaboration, community involvement, strategic partnerships.Staff fulfilment, coaching/mentoring, leadership development</td></tr><tr><td>5. Internal cohesion: Building internal organisational community</td><td>Shared values, vision, commitment, integrity, trust, passion, creativity, openness, transparency</td></tr><tr><td>4. Transformation: Continuous renewal and learning</td><td>Accountability, adaptability, empowerment, teamwork, goals orientation, personal growth</td></tr><tr><td>3. Self-esteem: High performance and quality of care</td><td>Systems, processes, quality, best practices, pride in performance.<i>Bureaucracy, arrogance, image, hoarding information</i></td></tr><tr><td>2. Relationships: With colleagues and patients</td><td>Loyalty, open communication, patient experience, friendship.<i>Blame, internal competition, rivalry, manipulation</i></td></tr><tr><td>1. Survival: Resources and safety</td><td>Sufficient budget, equipment, employee health, safety.<i>Control, chaos, caution, job security</i></td></tr></table>
<table><tr><td>Level of consciousness</td><td>Example of positive collective values</td></tr><tr><td>7. Service: Self-less service to the world</td><td>Social responsibility, future generations, long-term perspective, ethics, compassion, humility</td></tr></table>
<table><tr><td>6. Making a difference: to the local community or health district</td><td>Collaboration, community involvement, strategic partnerships.Staff fulfilment, coaching/mentoring, leadership development</td></tr><tr><td>5. Internal cohesion: Building internal organisational community</td><td>Shared values, vision, commitment, integrity, trust, passion, creativity, openness, transparency</td></tr><tr><td>4. Transformation: Continuous renewal and learning</td><td>Accountability, adaptability, empowerment, teamwork, goals orientation, personal growth</td></tr><tr><td>3. Self-esteem: High performance and quality of care</td><td>Systems, processes, quality, best practices, pride in performance.Bureaucracy, arrogance, image, hoarding information</td></tr><tr><td>2. Relationships: With colleagues and patients</td><td>Loyalty, open communication, patient experience, friendship.Blame, internal competition, rivalry, manipulation</td></tr><tr><td>1. Survival: Resources and safety</td><td>Sufficient budget, equipment, employee health, safety.Control, chaos, caution, job security</td></tr></table>
45b480826268871ddc70915cbe1a991121756a1283c1c24f56ac6558ddfcd128.png
simple
<table><tr><td></td><td>Number</td><td>Response rate</td></tr><tr><td>Invitational e-mails sent</td><td>1345</td><td>17% (227/1345)</td></tr><tr><td>Valid emails addresses</td><td>1131</td><td>20% (227/1131)</td></tr><tr><td>Emails opened</td><td>693</td><td>33% (227/693)</td></tr><tr><td>Links to survey opened</td><td>293</td><td>77% (227/293)</td></tr><tr><td>Participants that completed survey</td><td>227</td><td></td></tr></table>
<table><tr><td></td><td>Number</td><td>Response rate</td></tr><tr><td>Invitational e-mails sent</td><td>1345</td><td>17% (227/1345)</td></tr><tr><td>Va</td><td>11</td><td>20% (227</td></tr></table>
<table><tr><td>lid emails addresses</td><td>31</td><td>/1131)</td></tr><tr><td>Emails opened</td><td>693</td><td>33% (227/693)</td></tr><tr><td>Links to survey opened</td><td>293</td><td>77% (227/293)</td></tr><tr><td>Participants that completed survey</td><td>227</td><td></td></tr></table>
7389b3ee7e122e2bf76e9c3c4091e0034f468a87f45e2a31fad68f52f725929a.png
simple
<table><tr><td><i>&#961;</i></td><td><i>Method</i></td><td><i>Auc</i></td><td><i>Sensitivity</i></td><td><i>nIMS</i></td><td><i>nTMS</i></td></tr><tr><td>0.3</td><td><i>AucEN</i></td><td>0.81</td><td>0.45</td><td>3</td><td>12</td></tr><tr><td></td><td><i>AucL</i></td><td>0.81</td><td>0.45</td><td>3</td><td>6</td></tr><tr><td></td><td><i>LogEN</i></td><td>0.85</td><td>0.50</td><td>3</td><td>3</td></tr><tr><td></td><td><i>LogL</i></td><td>0.85</td><td>0.50</td><td>2</td><td>2</td></tr><tr><td></td><td><i>MSauc</i></td><td>0.82</td><td>0.45</td><td>2</td><td>6</td></tr><tr><td>0.9</td><td><i>AucEN</i></td><td>0.81</td><td>0.45</td><td>3</td><td>4</td></tr><tr><td></td><td><i>AucL</i></td><td>0.81</td><td>0.45</td><td>2</td><td>2</td></tr><tr><td></td><td><i>LogEN</i></td><td>0.80</td><td>0.40</td><td>2</td><td>2</td></tr><tr><td></td><td><i>LogL</i></td><td>0.80</td><td>0.40</td><td>1</td><td>1</td></tr><tr><td></td><td><i>MSauc</i></td><td>0.79</td><td>0.40</td><td>1</td><td>3</td></tr></table>
<table><tr><td>ρ</td><td>Method</td><td>Auc</td><td>Sensitivity</td><td>nIMS</td><td>nTMS</td></tr><tr><td>0.3</td><td>AucEN</td><td>0.81</td><td>0.45</td><td>3</td><td>12</td></tr><tr><td></td><td>AucL</td><td>0.81</td><td>0.45</td><td>3</td><td>6</td></tr><tr><td></td><td>LogEN</td><td>0.85</td><td>0.50</td><td>3</td><td>3</td></tr></table>
<table><tr><td>ρ</td><td>Method</td><td>Auc</td><td>Sensitivity</td><td>nIMS</td><td>nTMS</td></tr><tr><td></td><td>LogL</td><td>0.85</td><td>0.50</td><td>2</td><td>2</td></tr><tr><td></td><td>MSauc</td><td>0.82</td><td>0.45</td><td>2</td><td>6</td></tr><tr><td>0.9</td><td>AucEN</td><td>0.81</td><td>0.45</td><td>3</td><td>4</td></tr><tr><td></td><td>AucL</td><td>0.81</td><td>0.45</td><td>2</td><td>2</td></tr><tr><td></td><td>LogEN</td><td>0.80</td><td>0.40</td><td>2</td><td>2</td></tr><tr><td></td><td>LogL</td><td>0.80</td><td>0.40</td><td>1</td><td>1</td></tr><tr><td></td><td>MSauc</td><td>0.79</td><td>0.40</td><td>1</td><td>3</td></tr></table>
1712cf5a4193c255f010bf4f31bd1ec0fc71983f69fed6e0207daeef04963b65.png
simple
<table><tr><td></td><td>III.2</td><td>III.3</td><td>III.6</td><td>III.7</td><td>III.8 (Proband)</td><td>III.9</td></tr><tr><td>Lab ID</td><td>PI-2568</td><td>PI-2569</td><td>PI-2570</td><td>PI-1202</td><td>PI-1124</td><td>PI-2571</td></tr><tr><td>Gender</td><td>F</td><td>F</td><td>F</td><td>M</td><td>M</td><td>F</td></tr><tr><td><i>ATXN10</i> repeat (SMRT/Cas9 capture)*</td><td>1315</td><td>1363</td><td>1076</td><td>1363</td><td>1304</td><td>1080</td></tr><tr><td>Age at onset (years)</td><td>35</td><td>48</td><td>unaffected</td><td>48</td><td>38</td><td>37</td></tr><tr><td>Onset of seizures (years)</td><td>60</td><td>57</td><td>&#8211;</td><td>53</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Current age (years)</td><td>71</td><td>68</td><td>61</td><td>65</td><td>57</td><td>53</td></tr><tr><td>Duration of disease (years)</td><td>36</td><td>20</td><td>&#8211;</td><td>17</td><td>19</td><td>16</td></tr><tr><td>Seizures</td><td>+</td><td>+</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Gait ataxia</td><td>+</td><td>+</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>+</td></tr><tr><td>Intention tremor</td><td>+</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td></tr><tr><td>Dysarthria</td><td>+</td><td>+</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>+</td></tr><tr><td>Dysmetria</td><td>+</td><td>+</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>+</td></tr><tr><td>Dysdiadochokinesia</td><td>+</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>+</td></tr><tr><td>Nystagmus</td><td>+</td><td>+</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>+</td></tr><tr><td>Ocular dyskinesia</td><td>+</td><td>+</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Hypotonia</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Hyperreflexia</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Babinski&#8217;s sign</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Leg spasticity</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td></tr><tr><td>Aggressiveness</td><td>+</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>+</td></tr><tr><td>Depression</td><td>+</td><td>+</td><td>&#8211;</td><td>+</td><td>+</td><td>+</td></tr><tr><td>MoCA</td><td>9/30</td><td>2/30</td><td>29/30</td><td>U</td><td>U</td><td>25/30</td></tr><tr><td>SARA</td><td>23.5/40</td><td>24.5/40</td><td>0/40</td><td>U</td><td>6/40</td><td>16/40</td></tr><tr><td>B-SIT (% tile)</td><td>NP</td><td>NP</td><td>27%</td><td>U</td><td>29%</td><td>20%</td></tr><tr><td>B-SIT (category)</td><td>NP</td><td>NP</td><td>Normal</td><td>U</td><td>Normal</td><td>Normal</td></tr></table>
<table><tr><td></td><td>III.2</td><td>III.3</td><td>III.6</td><td>III.7</td><td>III.8 (Proband)</td><td>III.9</td></tr><tr><td>Lab ID</td><td>PI-2568</td><td>PI-2569</td><td>PI-2570</td><td>PI-1202</td><td>PI-1124</td><td>PI-2571</td></tr><tr><td>Gender</td><td>F</td><td>F</td><td>F</td><td>M</td><td>M</td><td>F</td></tr></table>
<table><tr><td>ATXN10 repeat (SMRT/Cas9 capture)*</td><td>1315</td><td>1363</td><td>1076</td><td>1363</td><td>1304</td><td>1080</td></tr><tr><td>Age at onset (years)</td><td>35</td><td>48</td><td>unaffected</td><td>48</td><td>38</td><td>37</td></tr><tr><td>Onset of seizures (years)</td><td>60</td><td>57</td><td>–</td><td>53</td><td>–</td><td>–</td></tr><tr><td>Current age (years)</td><td>71</td><td>68</td><td>61</td><td>65</td><td>57</td><td>53</td></tr><tr><td>Duration of disease (years)</td><td>36</td><td>20</td><td>–</td><td>17</td><td>19</td><td>16</td></tr><tr><td>Seizures</td><td>+</td><td>+</td><td>–</td><td>+</td><td>–</td><td>–</td></tr><tr><td>Gait ataxia</td><td>+</td><td>+</td><td>–</td><td>+</td><td>–</td><td>+</td></tr><tr><td>Intention tremor</td><td>+</td><td>+</td><td>–</td><td>–</td><td>+</td><td>–</td></tr><tr><td>Dysarthria</td><td>+</td><td>+</td><td>–</td><td>+</td><td>–</td><td>+</td></tr><tr><td>Dysmetria</td><td>+</td><td>+</td><td>–</td><td>+</td><td>–</td><td>+</td></tr><tr><td>Dysdiadochokinesia</td><td>+</td><td>+</td><td>–</td><td>–</td><td>+</td><td>+</td></tr><tr><td>Nystagmus</td><td>+</td><td>+</td><td>–</td><td>+</td><td>–</td><td>+</td></tr><tr><td>Ocular dyskinesia</td><td>+</td><td>+</td><td>–</td><td>+</td><td>–</td><td>–</td></tr><tr><td>Hypotonia</td><td>–</td><td>–</td><td>–</td><td>–</td><td>–</td><td>–</td></tr><tr><td>Hyperreflexia</td><td>–</td><td>–</td><td>–</td><td>+</td><td>–</td><td>–</td></tr><tr><td>Babinski’s sign</td><td>–</td><td>–</td><td>–</td><td>–</td><td>–</td><td>–</td></tr><tr><td>Leg spasticity</td><td>–</td><td>–</td><td>–</td><td>–</td><td>–</td><td>–</td></tr><tr><td>Aggressiveness</td><td>+</td><td>+</td><td>–</td><td>–</td><td>–</td><td>+</td></tr><tr><td>Depression</td><td>+</td><td>+</td><td>–</td><td>+</td><td>+</td><td>+</td></tr><tr><td>MoCA</td><td>9/30</td><td>2/30</td><td>29/30</td><td>U</td><td>U</td><td>25/30</td></tr><tr><td>SARA</td><td>23.5/40</td><td>24.5/40</td><td>0/40</td><td>U</td><td>6/40</td><td>16/40</td></tr><tr><td>B-SIT (% tile)</td><td>NP</td><td>NP</td><td>27%</td><td>U</td><td>29%</td><td>20%</td></tr><tr><td>B-SIT (category)</td><td>NP</td><td>NP</td><td>Normal</td><td>U</td><td>Normal</td><td>Normal</td></tr></table>
3a8a948bca355f35499fd93e6355efd67c2938320b923515b752cad24f2cd91d.png
complex
<table><tr><td></td><td>Controls</td><td>Carcinomas</td><td>Adenomas, all</td><td>High-risk adenomas</td><td>Low-risk adenomas</td></tr><tr><td></td><td>No (%)</td><td>No (%)</td><td>No (%)</td><td>No (%)</td><td>No (%)</td></tr><tr><td>No. of subjects</td><td>399</td><td>157</td><td>983</td><td>227</td><td>756</td></tr><tr><td colspan="6">Gender<sup>a</sup></td></tr><tr><td>Male</td><td>157 (39.3)</td><td>87 (55.4)</td><td>603 (61.3)</td><td>150 (66.1)</td><td>453 (59.9)</td></tr><tr><td>Female</td><td>242 (60.7)</td><td>70 (44.6)</td><td>380 (38.7)</td><td>77 (33.9)</td><td>303 (40.1)</td></tr><tr><td colspan="6">Age<sup>b</sup></td></tr><tr><td>Mean (SD)</td><td>54.2 (3.3)</td><td>67.9 (11.2)</td><td>57.3 (3.7)</td><td>57.3 (3.5)</td><td>57.3 (3.8)</td></tr><tr><td colspan="6">Smoking status * </td></tr><tr><td>Never smoked</td><td>155 (46.7)</td><td>33(31.1)</td><td>253 (30.6)</td><td>51 (27.0)</td><td>202 (31.7)</td></tr><tr><td>Ever smoked</td><td>177 (53.3)</td><td>73 (68.9)</td><td>574 (69.4)</td><td>138 (73.0)</td><td>436 (68.3)</td></tr><tr><td>Mean no. of cigarette years (SD)</td><td>249(229)</td><td>383(339)</td><td>360(263)</td><td>389(244)</td><td>351(269)</td></tr><tr><td colspan="6">Alcohol consumption * </td></tr><tr><td>&lt; 1 unit/month</td><td>72 (21.7)</td><td>36 (34.0)</td><td>180 (21.8)</td><td>43 (22.8)</td><td>137 (21.5)</td></tr><tr><td>&#8805; 1 unit/month</td><td>260 (78.3)</td><td>70 (66.0)</td><td>647 (78.2)</td><td>146 (77.2)</td><td>501 (78.5)</td></tr><tr><td>Mean units of alcohol per month (SD)</td><td>11.1 (12.2)</td><td>15.5 (22.3)</td><td>16.4 (22.9)</td><td>18.4 (29.8)</td><td>15.8 (20.4)</td></tr></table>
<table><tr><td></td><td>Controls</td><td>Carcinomas</td></tr><tr><td></td><td>No (%)</td><td>No (%)</td></tr><tr><td>No. of subjects</td><td>399</td><td>157</td></tr><tr><td colspan="3">Gendera</td></tr><tr><td>Male</td><td>157 (39.3)</td><td>87 (55.4)</td></tr><tr><td>Female</td><td>242 (60.7)</td><td>70 (44.6)</td></tr><tr><td colspan="3">Ageb</td></tr><tr><td>Mean (SD)</td><td>54.2 (3.3)</td><td>67.9 (11.2)</td></tr><tr><td colspan="3">Smoking status *</td></tr><tr><td>Never smoked</td><td>155 (46.7)</td><td>33(31.1)</td></tr><tr><td>Ever smoked</td><td>177 (53.3)</td><td>73 (68.9)</td></tr><tr><td>Mean no. of cigarette years (SD)</td><td>249(229)</td><td>383(339)</td></tr><tr><td colspan="3">Alcohol consumption *</td></tr><tr><td>< 1 unit/month</td><td>72 (21.7)</td><td>36 (34.0)</td></tr><tr><td>≥ 1 unit/month</td><td>260 (78.3)</td><td>70 (66.0)</td></tr><tr><td>Mean units of alcohol per month (SD)</td><td>11.1 (12.2)</td><td>15.5 (22.3)</td></tr></table>
<table><tr><td>Adenomas, all</td><td>High-risk adenomas</td><td>Low-risk adenomas</td></tr><tr><td>No (%)</td><td>No (%)</td><td>No (%)</td></tr><tr><td>983</td><td>227</td><td>756</td></tr><tr><td colspan="3">Gendera</td></tr><tr><td>603 (61.3)</td><td>150 (66.1)</td><td>453 (59.9)</td></tr><tr><td>380 (38.7)</td><td>77 (33.9)</td><td>303 (40.1)</td></tr><tr><td colspan="3">Ageb</td></tr><tr><td>57.3 (3.7)</td><td>57.3 (3.5)</td><td>57.3 (3.8)</td></tr><tr><td colspan="3">Smoking status *</td></tr><tr><td>253 (30.6)</td><td>51 (27.0)</td><td>202 (31.7)</td></tr><tr><td>574 (69.4)</td><td>138 (73.0)</td><td>436 (68.3)</td></tr><tr><td>360(263)</td><td>389(244)</td><td>351(269)</td></tr><tr><td colspan="3">Alcohol consumption *</td></tr><tr><td>180 (21.8)</td><td>43 (22.8)</td><td>137 (21.5)</td></tr><tr><td>647 (78.2)</td><td>146 (77.2)</td><td>501 (78.5)</td></tr><tr><td>16.4 (22.9)</td><td>18.4 (29.8)</td><td>15.8 (20.4)</td></tr></table>
ad3ac3d1cd9756aaa0011081831efa944472b80769c49f65e9cc1e37779f536f.png
simple
<table><tr><td>Species and tissue or cell type</td><td>Relevant properties of tissue or cells</td><td>Name of library in NCBI and contributor(s)</td><td>Total number of ESTs per library (March 2006)</td><td>Number of ESTs matching genes in <i>Arabidopsis </i>(e &lt; 10<sup>-7</sup>)</td><td>Number of contigs identified using CAP3</td><td>Number of singletons identified using CAP3</td><td>Unigenes (contigs plus singletons)</td></tr><tr><td><i>Zea mays</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Sperm</td><td>Male</td><td><i>Zea mays </i>sperm cell cDNA library (S. McCormick) Engel et al.[64]</td><td>5174</td><td>2457</td><td>384</td><td>781</td><td>1165</td></tr><tr><td>Egg</td><td>Female</td><td><i>Zea mays </i>egg cell cDNA library (H. Yang and S. McCormick) Yang et al. [65]</td><td>4085</td><td>1957</td><td>264</td><td>863</td><td>1127</td></tr><tr><td><i>Triticum aestivum</i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Anther-meiotic</td><td>Male</td><td>Wheat meiotic anther cDNA library (O. Anderson)</td><td>9139</td><td>6118</td><td>860</td><td>3058</td><td>3918</td></tr><tr><td>Ovary</td><td>Female</td><td>Ov (Genoplante)</td><td>5311</td><td>3699</td><td>813</td><td>1295</td><td>2108</td></tr><tr><td><i>Brassica napus </i></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Microspores (from 3 to 4 mm buds)</td><td>Male</td><td>65JKBNM0 (M. Malik and J. Krochko)</td><td>6539</td><td>5325</td><td>781</td><td>1620</td><td>2401</td></tr><tr><td>Buds and young flowers</td><td>Heterogeneous (male, female and somatic)</td><td>ADIS-MPIZ 021 (B. Weisshaar)</td><td>8747</td><td>6164</td><td>995</td><td>2665</td><td>3660</td></tr></table>
<table><tr><td>Species and tissue or cell type</td></tr><tr><td>Zea mays</td></tr><tr><td>Sperm</td></tr><tr><td>Egg</td></tr><tr><td>Triticum aestivum</td></tr><tr><td>Anther-meiotic</td></tr><tr><td>Ovary</td></tr><tr><td>Brassica napus</td></tr><tr><td>Microspores (from 3 to 4 mm buds)</td></tr><tr><td>Buds and young flowers</td></tr></table>
<table><tr><td>Relevant properties of tissue or cells</td><td>Name of library in NCBI and contributor(s)</td><td>Total number of ESTs per library (March 2006)</td><td>Number of ESTs matching genes in Arabidopsis (e < 10-7)</td><td>Number of contigs identified using CAP3</td><td>Number of singletons identified using CAP3</td><td>Unigenes (contigs plus singletons)</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>Zea mays sperm cell cDNA library (S. McCormick) Engel et al.[64]</td><td>5174</td><td>2457</td><td>384</td><td>781</td><td>1165</td></tr><tr><td>Female</td><td>Zea mays egg cell cDNA library (H. Yang and S. McCormick) Yang et al. [65]</td><td>4085</td><td>1957</td><td>264</td><td>863</td><td>1127</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>Wheat meiotic anther cDNA library (O. Anderson)</td><td>9139</td><td>6118</td><td>860</td><td>3058</td><td>3918</td></tr><tr><td>Female</td><td>Ov (Genoplante)</td><td>5311</td><td>3699</td><td>813</td><td>1295</td><td>2108</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>65JKBNM0 (M. Malik and J. Krochko)</td><td>6539</td><td>5325</td><td>781</td><td>1620</td><td>2401</td></tr><tr><td>Heterogeneous (male, female and somatic)</td><td>ADIS-MPIZ 021 (B. Weisshaar)</td><td>8747</td><td>6164</td><td>995</td><td>2665</td><td>3660</td></tr></table>
354a30a37e2cb6ad6773414c0bfdc564cde359d752e66a51608e19fc4116706c.png
simple
<table><tr><td>Region no.</td><td>ORF<sup>a</sup></td><td>Region size (nt)</td><td>Size of sequenced region (nt)</td><td>Left coordinate<sup>a</sup></td><td>Right coordinate<sup>a</sup></td><td>Newly found changes in the regions suggested by CGS</td><td>Newly found changes not suggested by mapping phase of CGS</td><td>Confirmation of SNPs identified by CGS in this region<sup>b</sup></td></tr><tr><td>1</td><td>TP0012</td><td>37</td><td>390</td><td>12322</td><td>12711</td><td>3 nt deletion</td><td>-</td><td>-</td></tr><tr><td>2</td><td>TP0076</td><td>29</td><td>529</td><td>83788</td><td>84316</td><td>-</td><td>1 solitary SNP</td><td>-</td></tr><tr><td>3</td><td>TP0117</td><td>86</td><td>699</td><td>134808</td><td>135506</td><td>7 clustered SNPs</td><td>-</td><td>-</td></tr><tr><td>4</td><td>TP0117</td><td>86</td><td></td><td></td><td></td><td>3 clustered SNPs</td><td>-</td><td>-</td></tr><tr><td>5</td><td>TP0126</td><td>29</td><td>393</td><td>147948</td><td>148340</td><td>1 solitary SNP</td><td>-</td><td>-</td></tr><tr><td>6</td><td>upstream</td><td>29</td><td>460</td><td>149103</td><td>149562</td><td>2 clustered SNPs</td><td>-</td><td>-</td></tr><tr><td></td><td>of TP0128</td><td></td><td></td><td></td><td></td><td>1 nt + 5 nt insertions</td><td></td><td></td></tr><tr><td>7</td><td>TP0131</td><td>421</td><td>723</td><td>150925</td><td>151647</td><td>3 clustered SNPs, 1 solitary SNP</td><td>2 clustered SNPs</td><td>-</td></tr><tr><td>8</td><td>upstream of TP0136</td><td>29</td><td>404</td><td>156348</td><td>156751</td><td>64 nt deletion</td><td>-</td><td>-</td></tr><tr><td>9</td><td>TP0136</td><td>1087</td><td>1609</td><td>156752</td><td>158360</td><td>19 clustered SNPs</td><td>8 clustered SNPs</td><td>21 SNPs</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>1 nt + 1 nt + 1 nt + 6 nt deletions</td><td>2 solitary SNPs</td><td></td></tr><tr><td>10</td><td>TP0272</td><td>29</td><td>480</td><td>288647</td><td>289126</td><td>-</td><td>-</td><td>-</td></tr><tr><td>11</td><td>TP0304</td><td>37</td><td>466</td><td>318761</td><td>319226</td><td>3 nt deletion</td><td>-</td><td>-</td></tr><tr><td>12</td><td>TP0326</td><td>79</td><td>452</td><td>345605</td><td>346056</td><td>8 clustered SNPs</td><td>-</td><td>1 SNP</td></tr><tr><td>13</td><td>TP0352</td><td>29</td><td>465</td><td>376926</td><td>377390</td><td>-</td><td>-</td><td>-</td></tr><tr><td>14</td><td>TP0394</td><td>29</td><td>505</td><td>420353</td><td>420857</td><td>-</td><td>-</td><td>1 SNP</td></tr><tr><td>15</td><td>TP0431</td><td>29</td><td>465</td><td>458973</td><td>459437</td><td>-</td><td>-</td><td>1 SNP</td></tr><tr><td>16</td><td>TP0457</td><td>29</td><td>465</td><td>487935</td><td>488399</td><td>-</td><td>-</td><td>-</td></tr><tr><td>17</td><td>TP0484</td><td>29</td><td>468</td><td>514441</td><td>514908</td><td>-</td><td>-</td><td>-</td></tr><tr><td>18</td><td>TP0486</td><td>29</td><td>494</td><td>517297</td><td>517790</td><td>-</td><td>1 nt insertion, 1 nt deletion</td><td>-</td></tr><tr><td>19</td><td>TP0493</td><td>29</td><td>478</td><td>529146</td><td>529623</td><td>-</td><td>-</td><td>-</td></tr><tr><td>20</td><td>TP0515</td><td>44</td><td>506</td><td>555754</td><td>556259</td><td>3 clustered SNPs</td><td>-</td><td>4 SNPs</td></tr><tr><td>21</td><td>TP0544</td><td>29</td><td>611</td><td>585940</td><td>586550</td><td>6 nt insertion</td><td>-</td><td>-</td></tr><tr><td>22</td><td>TP0548</td><td>835</td><td>1189</td><td>591557</td><td>592745</td><td>22 clustered SNPs</td><td>2 clustered SNPs</td><td>5 SNPs</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>3 nt + 4 nt + 5 nt insertions</td><td>1 solitary SNP</td><td></td></tr><tr><td>23</td><td>TP0577</td><td>37</td><td>405</td><td>628247</td><td>628651</td><td>1 solitary SNP</td><td>-</td><td>-</td></tr><tr><td>24</td><td>TP0598</td><td>29</td><td>550</td><td>648851</td><td>649400</td><td>-</td><td>4 1 nt insertions</td><td>-</td></tr><tr><td>25</td><td>TP0620&#8211;TP0621</td><td>51</td><td>3469</td><td>670958</td><td>674426</td><td>-</td><td>4 clustered SNPs</td><td>-</td></tr><tr><td>26</td><td>TP0668</td><td>37</td><td>462</td><td>730080</td><td>730541</td><td>6 nt deletion</td><td>-</td><td>-</td></tr><tr><td>27</td><td>TP0699</td><td>51</td><td>469</td><td>766143</td><td>766611</td><td>1 solitary SNP</td><td>-</td><td>-</td></tr><tr><td>28</td><td>TP0785</td><td>29</td><td>438</td><td>851631</td><td>852068</td><td>-</td><td>-</td><td>-</td></tr><tr><td>29</td><td>TP0814</td><td>29</td><td>476</td><td>882990</td><td>883465</td><td>-</td><td>-</td><td>-</td></tr><tr><td>30</td><td>TP0865</td><td>29</td><td>480</td><td>943847</td><td>944326</td><td>3 nt insertion</td><td>-</td><td>1 SNP</td></tr><tr><td>31</td><td>TP0866</td><td>29</td><td>543</td><td>944677</td><td>945219</td><td>-</td><td>1 nt insertion</td><td>-</td></tr><tr><td>32</td><td>TP0868</td><td>29</td><td>454</td><td>947257</td><td>947710</td><td>7 nt deletion</td><td>-</td><td>-</td></tr><tr><td>33</td><td>TP0896&#8211;TP0898</td><td>667</td><td>3038</td><td>974053</td><td>977090</td><td>4 SNPs<sup>c </sup>and 7 variable regions<sup>d</sup></td><td></td><td>1 SNP</td></tr><tr><td>34</td><td>TP0898</td><td>27</td><td>416</td><td>978349</td><td>978764</td><td>-</td><td>-</td><td>-</td></tr><tr><td>35</td><td>TP0933</td><td>29</td><td>164</td><td>1014034</td><td>1014197</td><td>-</td><td>-</td><td>-</td></tr><tr><td>36</td><td>TP0973</td><td>44</td><td>396</td><td>1057660</td><td>1058055</td><td>1 solitary SNP</td><td>-</td><td>1 SNP (igr)</td></tr><tr><td>37</td><td>TP1030&#8211;TP1031</td><td>1507</td><td>402</td><td>1123660</td><td>1124061</td><td>18 clustered SNPs</td><td>1 nt insertion,</td><td>16 SNPs</td></tr><tr><td></td><td></td><td></td><td>1775</td><td>1124256</td><td>1126030</td><td></td><td>1 solitary SNP</td><td></td></tr><tr><td>38</td><td>TP1036</td><td>29</td><td>550</td><td>1132558</td><td>1133107</td><td>-</td><td>-</td><td>-</td></tr></table>
<table><tr><td>Region no.</td><td>ORFa</td><td>Region size (nt)</td><td>Size of sequenced region (nt)</td><td>Left coordinatea</td><td>Right coordinatea</td><td>Newly found changes in the regions suggested by CGS</td><td>Newly found changes not suggested by mapping phase of CGS</td><td>Confirmation of SNPs identified by CGS in this regionb</td></tr><tr><td>1</td><td>TP0012</td><td>37</td><td>390</td><td>12322</td><td>12711</td><td>3 nt deletion</td><td>-</td><td>-</td></tr><tr><td>2</td><td>TP0076</td><td>29</td><td>529</td><td>83788</td><td>84316</td><td>-</td><td>1 solitary SNP</td><td>-</td></tr><tr><td>3</td><td>TP0117</td><td>86</td><td>699</td><td>134808</td><td>135506</td><td>7 clustered SNPs</td><td>-</td><td>-</td></tr><tr><td>4</td><td>TP0117</td><td>86</td><td></td><td></td><td></td><td>3 clustered SNPs</td><td>-</td><td>-</td></tr><tr><td>5</td><td>TP0126</td><td>29</td><td>393</td><td>147948</td><td>148340</td><td>1 solitary SNP</td><td>-</td><td>-</td></tr><tr><td>6</td><td>upstream</td><td>29</td><td>460</td><td>149103</td><td>149562</td><td>2 clustered SNPs</td><td>-</td><td>-</td></tr><tr><td></td><td>of TP0128</td><td></td><td></td><td></td><td></td><td>1 nt + 5 nt insertions</td><td></td><td></td></tr><tr><td>7</td><td>TP0131</td><td>421</td><td>723</td><td>150925</td><td>151647</td><td>3 clustered SNPs, 1 solitary SNP</td><td>2 clustered SNPs</td><td>-</td></tr><tr><td>8</td><td>upstream of TP0136</td><td>29</td><td>404</td><td>156348</td><td>156751</td><td>64 nt deletion</td><td>-</td><td>-</td></tr><tr><td>9</td><td>TP0136</td><td>1087</td><td>1609</td><td>156752</td><td>158360</td><td>19 clustered SNPs</td><td>8 clustered SNPs</td><td>21 SNPs</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>1 nt + 1 nt + 1 nt + 6 nt deletions</td><td>2 solitary SNPs</td><td></td></tr><tr><td>10</td><td>TP0272</td><td>29</td><td>480</td><td>288647</td><td>289126</td><td>-</td><td>-</td><td>-</td></tr><tr><td>11</td><td>TP0304</td><td>37</td><td>466</td><td>318761</td><td>319226</td><td>3 nt deletion</td><td>-</td><td>-</td></tr><tr><td>12</td><td>TP0326</td><td>79</td><td>452</td><td>345605</td><td>346056</td><td>8 clustered SNPs</td><td>-</td><td>1 SNP</td></tr><tr><td>13</td><td>TP0352</td><td>29</td><td>465</td><td>376926</td><td>377390</td><td>-</td><td>-</td><td>-</td></tr><tr><td>14</td><td>TP0394</td><td>29</td><td>505</td><td>420353</td><td>420857</td><td>-</td><td>-</td><td>1 SNP</td></tr><tr><td>15</td><td>TP0431</td><td>29</td><td>465</td><td>458973</td><td>459437</td><td>-</td><td>-</td><td>1 SNP</td></tr><tr><td>16</td><td>TP0457</td><td>29</td><td>465</td><td>487935</td><td>488399</td><td>-</td><td>-</td><td>-</td></tr><tr><td>17</td><td>TP0484</td><td>29</td><td>468</td><td>514441</td><td>514908</td><td>-</td><td>-</td><td>-</td></tr><tr><td>18</td><td>TP0486</td><td>29</td><td>494</td><td>517297</td><td>517790</td><td>-</td><td>1 nt insertion, 1 nt deletion</td><td>-</td></tr><tr><td>19</td><td>TP0493</td><td>29</td><td>478</td><td>529146</td><td>529623</td><td>-</td><td>-</td><td>-</td></tr><tr><td>20</td><td>TP0515</td><td>44</td><td>506</td><td>555754</td><td>556259</td><td>3 clustered SNPs</td><td>-</td><td>4 SNPs</td></tr><tr><td>21</td><td>TP0544</td><td>29</td><td>611</td><td>585940</td><td>586550</td><td>6 nt insertion</td><td>-</td><td>-</td></tr></table>
<table><tr><td>Region no.</td><td>ORFa</td><td>Region size (nt)</td><td>Size of sequenced region (nt)</td><td>Left coordinatea</td><td>Right coordinatea</td><td>Newly found changes in the regions suggested by CGS</td><td>Newly found changes not suggested by mapping phase of CGS</td><td>Confirmation of SNPs identified by CGS in this regionb</td></tr><tr><td>22</td><td>TP0548</td><td>835</td><td>1189</td><td>591557</td><td>592745</td><td>22 clustered SNPs</td><td>2 clustered SNPs</td><td>5 SNPs</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>3 nt + 4 nt + 5 nt insertions</td><td>1 solitary SNP</td><td></td></tr><tr><td>23</td><td>TP0577</td><td>37</td><td>405</td><td>628247</td><td>628651</td><td>1 solitary SNP</td><td>-</td><td>-</td></tr><tr><td>24</td><td>TP0598</td><td>29</td><td>550</td><td>648851</td><td>649400</td><td>-</td><td>4 1 nt insertions</td><td>-</td></tr><tr><td>25</td><td>TP0620–TP0621</td><td>51</td><td>3469</td><td>670958</td><td>674426</td><td>-</td><td>4 clustered SNPs</td><td>-</td></tr><tr><td>26</td><td>TP0668</td><td>37</td><td>462</td><td>730080</td><td>730541</td><td>6 nt deletion</td><td>-</td><td>-</td></tr><tr><td>27</td><td>TP0699</td><td>51</td><td>469</td><td>766143</td><td>766611</td><td>1 solitary SNP</td><td>-</td><td>-</td></tr><tr><td>28</td><td>TP0785</td><td>29</td><td>438</td><td>851631</td><td>852068</td><td>-</td><td>-</td><td>-</td></tr><tr><td>29</td><td>TP0814</td><td>29</td><td>476</td><td>882990</td><td>883465</td><td>-</td><td>-</td><td>-</td></tr><tr><td>30</td><td>TP0865</td><td>29</td><td>480</td><td>943847</td><td>944326</td><td>3 nt insertion</td><td>-</td><td>1 SNP</td></tr><tr><td>31</td><td>TP0866</td><td>29</td><td>543</td><td>944677</td><td>945219</td><td>-</td><td>1 nt insertion</td><td>-</td></tr><tr><td>32</td><td>TP0868</td><td>29</td><td>454</td><td>947257</td><td>947710</td><td>7 nt deletion</td><td>-</td><td>-</td></tr><tr><td>33</td><td>TP0896–TP0898</td><td>667</td><td>3038</td><td>974053</td><td>977090</td><td>4 SNPsc and 7 variable regionsd</td><td></td><td>1 SNP</td></tr><tr><td>34</td><td>TP0898</td><td>27</td><td>416</td><td>978349</td><td>978764</td><td>-</td><td>-</td><td>-</td></tr><tr><td>35</td><td>TP0933</td><td>29</td><td>164</td><td>1014034</td><td>1014197</td><td>-</td><td>-</td><td>-</td></tr><tr><td>36</td><td>TP0973</td><td>44</td><td>396</td><td>1057660</td><td>1058055</td><td>1 solitary SNP</td><td>-</td><td>1 SNP (igr)</td></tr><tr><td>37</td><td>TP1030–TP1031</td><td>1507</td><td>402</td><td>1123660</td><td>1124061</td><td>18 clustered SNPs</td><td>1 nt insertion,</td><td>16 SNPs</td></tr><tr><td></td><td></td><td></td><td>1775</td><td>1124256</td><td>1126030</td><td></td><td>1 solitary SNP</td><td></td></tr><tr><td>38</td><td>TP1036</td><td>29</td><td>550</td><td>1132558</td><td>1133107</td><td>-</td><td>-</td><td>-</td></tr></table>
7df43abd4c294664bf08cbdeba1d5b2aa740b0eef89e057a7f3bfb1a58a09464.png
simple
<table><tr><td>Independent variable</td><td>Odds ratio</td><td>Std. Err.</td><td>z</td><td>p</td><td>95% conf. interval</td></tr><tr><td>Basal circumference</td><td>1.21</td><td>0.08</td><td>2.79</td><td>0.005</td><td>[1.06; 1.39]</td></tr><tr><td>PwarmQ</td><td>3.90</td><td>0.70</td><td>7.63</td><td>&lt;0.001</td><td>[2.75; 5.53]</td></tr><tr><td>Ave. of the 5 windiest days</td><td>2.59</td><td>0.50</td><td>4.92</td><td>&lt;0.001</td><td>[1.77; 3.79]</td></tr><tr><td>Pwarmq*Ave. of the 5 windiest days</td><td>3.85</td><td>0.90</td><td>5.73</td><td>&lt;0.001</td><td>[2.43; 6.10]</td></tr><tr><td>Leptosols</td><td>4.86</td><td>1.54</td><td>4.99</td><td>&lt;0.001</td><td>[2.61; 9.04]</td></tr><tr><td>Regosols</td><td>0.67</td><td>0.13</td><td>&#8722;2.06</td><td>0.039</td><td>[0.46; 0.98]</td></tr><tr><td>Constant</td><td>0.21</td><td>0.05</td><td>&#8722;6.39</td><td>&lt;0.001</td><td>[0.13; 0.34]</td></tr></table>
<table><tr><td>Independent variable</td><td>Odds ratio</td><td>Std. Err.</td><td>z</td><td>p</td></tr><tr><td>Basal circumference</td><td>1.21</td><td>0.08</td><td>2.79</td><td>0.005</td></tr><tr><td>PwarmQ</td><td>3.90</td><td>0.70</td><td>7.63</td><td><0.001</td></tr><tr><td>Ave. of the 5 windiest days</td><td>2.59</td><td>0.50</td><td>4.92</td><td><0.001</td></tr><tr><td>Pwarmq*Ave. of the 5 windiest days</td><td>3.85</td><td>0.90</td><td>5.73</td><td><0.001</td></tr><tr><td>Leptosols</td><td>4.86</td><td>1.54</td><td>4.99</td><td><0.001</td></tr><tr><td>Regosols</td><td>0.67</td><td>0.13</td><td>−2.06</td><td>0.039</td></tr><tr><td>Constant</td><td>0.21</td><td>0.05</td><td>−6.39</td><td><0.001</td></tr></table>
<table><tr><td>95% conf. interval</td></tr><tr><td>[1.06; 1.39]</td></tr><tr><td>[2.75; 5.53]</td></tr><tr><td>[1.77; 3.79]</td></tr><tr><td>[2.43; 6.10]</td></tr><tr><td>[2.61; 9.04]</td></tr><tr><td>[0.46; 0.98]</td></tr><tr><td>[0.13; 0.34]</td></tr></table>
6b9e2c95433f1c79849f76eb40220726ce4a103fdae719217b7552aa2d63ac9a.png
simple
<table><tr><td> </td><td>Body weight (g)</td><td>GHb (%)</td><td>Urine volume (ml/24 hours)</td></tr><tr><td>Normal</td><td>618 &#177; 71</td><td>5.7 &#177; 0.6</td><td>9 &#177; 8</td></tr><tr><td>Diabetes</td><td>369 &#177; 65</td><td>11.1 &#177; 2.1*</td><td>106 &#177; 20*</td></tr><tr><td>Diab + Nutr</td><td>354 &#177; 63</td><td>9.8 &#177; 2.4*</td><td>92 &#177; 42*</td></tr></table>
<table><tr><td></td><td>Body weight (g)</td><td>GHb (%)</td><td>Urine volume (ml/24 hours)</td></tr><tr><td>Normal</td><td>618 ± 71</td><td>5.7 ± 0.6</td><td>9 ± 8</td></tr><tr><td>Diabetes</td><td>369 ± 65</td><td>11.1 ± 2.1*</td><td>106 ± 20*</td></tr></table>
<table><tr><td></td><td>Body weight (g)</td><td>GHb (%)</td><td>Urine volume (ml/24 hours)</td></tr><tr><td>Diab + Nutr</td><td>354 ± 63</td><td>9.8 ± 2.4*</td><td>92 ± 42*</td></tr></table>
7bd788aff8ca2bf14a17f10463dc68d6ac1f81cb04e7a6af4723abb796d191a2.png
complex
<table><tr><td></td><td>Average gold-standard</td><td>Average real-time</td><td>Wilcoxon p-value</td></tr><tr><td colspan="4">For all subjects (63/63)</td></tr><tr><td>Endocardial border</td><td>3.9</td><td>3.9</td><td>0.23</td></tr><tr><td>Papillary muscle</td><td>4.0</td><td>3.9</td><td>0.03*</td></tr><tr><td>Blood pool</td><td>4.0</td><td>3.6</td><td>&lt;0.001*</td></tr><tr><td>Mitral valve</td><td>3.9</td><td>3.4</td><td>&lt;0.001*</td></tr><tr><td>Myocardium</td><td>3.9</td><td>3.9</td><td>0.45</td></tr><tr><td>Cardiac motion</td><td>3.9</td><td>3.9</td><td>1.00</td></tr><tr><td colspan="4">Radial GRAPPA with 26 calibration frames (23/63)</td></tr><tr><td>Endocardial border</td><td>3.9</td><td>3.9</td><td>0.73</td></tr><tr><td>Papillary muscle</td><td>4.0</td><td>4.0</td><td>0.71</td></tr><tr><td>Blood pool</td><td>4.0</td><td>3.7</td><td>&lt;0.01*</td></tr><tr><td>Mitral valve</td><td>3.8</td><td>3.2</td><td>&lt;0.001*</td></tr><tr><td>Myocardium</td><td>3.9</td><td>4.0</td><td>0.17</td></tr><tr><td>Cardiac motion</td><td>3.9</td><td>4.0</td><td>0.14</td></tr><tr><td colspan="4">Radial GRAPPA with 6 calibration frames (40/63)</td></tr><tr><td>Endocardial border</td><td>4.0</td><td>3.9</td><td>0.05</td></tr><tr><td>Papillary muscle</td><td>4.0</td><td>3.9</td><td>0.02*</td></tr><tr><td>Blood pool</td><td>4.0</td><td>3.6</td><td>&lt;0.001*</td></tr><tr><td>Mitral valve</td><td>3.9</td><td>3.5</td><td>&lt;0.001*</td></tr><tr><td>Myocardium</td><td>4.0</td><td>3.9</td><td>0.07</td></tr><tr><td>Cardiac motion</td><td>4.0</td><td>3.9</td><td>0.23</td></tr></table>
<table><tr><td></td><td>Average gold-standard</td><td>Average real-time</td><td>Wilcoxon p-value</td></tr><tr><td colspan="4">For all subjects (63/63)</td></tr><tr><td>Endocardial border</td><td>3.9</td><td>3.9</td><td>0.23</td></tr><tr><td>Papillary muscle</td><td>4.0</td><td>3.9</td><td>0.03*</td></tr><tr><td>Blood pool</td><td>4.0</td><td>3.6</td><td><0.001*</td></tr><tr><td>Mitral valve</td><td>3.9</td><td>3.4</td><td><0.001*</td></tr><tr><td>Myocardium</td><td>3.9</td><td>3.9</td><td>0.45</td></tr><tr><td>Cardiac motion</td><td>3.9</td><td>3.9</td><td>1.00</td></tr><tr><td colspan="4">Radial GRAPPA with 26 calibration frames (23/63)</td></tr><tr><td>Endocardial border</td><td>3.9</td><td>3.9</td><td>0.73</td></tr><tr><td>Papillary muscle</td><td>4.0</td><td>4.0</td><td>0.71</td></tr><tr><td>Blood pool</td><td>4.0</td><td>3.7</td><td><0.01*</td></tr><tr><td>Mitral valve</td><td>3.8</td><td>3.2</td><td><0.001*</td></tr><tr><td>Myocardium</td><td>3.9</td><td>4.0</td><td>0.17</td></tr></table>
<table><tr><td>Cardiac motion</td><td>3.9</td><td>4.0</td><td>0.14</td></tr><tr><td colspan="4">Radial GRAPPA with 6 calibration frames (40/63)</td></tr><tr><td>Endocardial border</td><td>4.0</td><td>3.9</td><td>0.05</td></tr><tr><td>Papillary muscle</td><td>4.0</td><td>3.9</td><td>0.02*</td></tr><tr><td>Blood pool</td><td>4.0</td><td>3.6</td><td><0.001*</td></tr><tr><td>Mitral valve</td><td>3.9</td><td>3.5</td><td><0.001*</td></tr><tr><td>Myocardium</td><td>4.0</td><td>3.9</td><td>0.07</td></tr><tr><td>Cardiac motion</td><td>4.0</td><td>3.9</td><td>0.23</td></tr></table>
dde202fab2183a1cbf85cef2cd5be5db0e8c798fcab70cf7b289ecc28dffbae6.png
complex
<table><tr><td> </td><td colspan="4">Stepwise multiple regression</td><td colspan="3">Predictor variables</td></tr><tr><td rowspan="2"> </td><td>Model</td><td> </td><td> </td><td> </td><td><i>Variable</i></td><td><i>Beta</i></td><td><i>P</i></td></tr><tr><td><i>F</i></td><td><i>df</i></td><td><i>P</i></td><td>R<sup>2</sup></td><td> </td><td> </td><td> </td></tr><tr><td rowspan="3">B cells all</td><td rowspan="3">21.650</td><td rowspan="3">3</td><td rowspan="3">0.000</td><td rowspan="3">0.391</td><td>CXCL13</td><td>0.745</td><td>0.000</td></tr><tr><td>CXCL12</td><td>&#8722;0.490</td><td>0.001</td></tr><tr><td>BAFF</td><td>0.320</td><td>0.012</td></tr><tr><td>B cells</td><td>18.098</td><td>2</td><td>0.000</td><td>0.262</td><td>CXCL13</td><td>0.616</td><td>0.000</td></tr><tr><td> </td><td> </td><td> </td><td> </td><td> </td><td>CXCL12</td><td>&#8722;0.271</td><td>0.010</td></tr><tr><td>Plasmablasts</td><td>20.265</td><td>2</td><td>0.000</td><td>0.287</td><td>CXCL13</td><td>0.413</td><td>0.000</td></tr><tr><td> </td><td> </td><td> </td><td> </td><td> </td><td>BAFF</td><td>0.234</td><td>0.009</td></tr><tr><td>T cells</td><td>6.001</td><td>2</td><td>0.003</td><td>0.110</td><td>BAFF</td><td>&#8722;0.498</td><td>0.001</td></tr><tr><td> </td><td> </td><td> </td><td> </td><td> </td><td>APRIL</td><td>0.296</td><td>0.05</td></tr><tr><td>Monocytes</td><td> </td><td> </td><td> </td><td> </td><td>No variables included</td><td> </td><td> </td></tr></table>
<table><tr><td></td><td colspan="4">Stepwise multiple regression</td><td colspan="3">Predictor variables</td></tr><tr><td rowspan="2"></td><td>Model</td><td></td><td></td><td></td><td>Variable</td><td>Beta</td><td>P</td></tr><tr><td>F</td><td>df</td><td>P</td><td>R2</td><td></td><td></td><td></td></tr><tr><td rowspan="3">B cells all</td><td rowspan="3">21.650</td><td rowspan="3">3</td><td rowspan="3">0.000</td><td rowspan="3">0.391</td><td>CXCL13</td><td>0.745</td><td>0.000</td></tr><tr><td>CXCL12</td><td>−0.490</td><td>0.001</td></tr><tr><td>BAFF</td><td>0.320</td><td>0.012</td></tr><tr><td>B cells</td><td>18.098</td><td>2</td><td>0.000</td><td>0.262</td><td>CXCL13</td><td>0.616</td><td>0.000</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td>CXCL12</td><td>−0.271</td><td>0.010</td></tr><tr><td>Plasmablasts</td><td>20.265</td><td>2</td><td>0.000</td><td>0.287</td><td>CXCL13</td><td>0.413</td><td>0.000</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td>BAFF</td><td>0.234</td><td>0.009</td></tr><tr><td>T</td><td>6.001</td><td></td><td>0.</td><td>0.</td><td></td><td>−0.</td><td>0</td></tr></table>
<table><tr><td> cells</td><td></td><td>2</td><td>003</td><td>110</td><td>BAFF</td><td>498</td><td>.001</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td>APRIL</td><td>0.296</td><td>0.05</td></tr><tr><td>Monocytes</td><td></td><td></td><td></td><td></td><td>No variables included</td><td></td><td></td></tr></table>
82b4acd2b9739072142a742e6ab7e6eef27ae95d669234f6b5411ff714d4368c.png
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<table><tr><td>Country</td><td>Years</td></tr><tr><td>Bangladesh</td><td>1999</td></tr><tr><td>Benin</td><td>2006, 2001, 1996</td></tr><tr><td>Bolivia</td><td>2003, 1998</td></tr><tr><td>Cameroon</td><td>2004, 1998, 1991</td></tr><tr><td>Colombia</td><td>2010, 2005, 2000, 1995</td></tr><tr><td>Dominican republic</td><td>2007, 1999, 1996</td></tr><tr><td>Egypt</td><td>2008, 2005, 2000, 1996</td></tr><tr><td>Ghana</td><td>2008, 2003, 1993</td></tr><tr><td>India</td><td>2005, 1992</td></tr><tr><td>Indonesia</td><td>2007</td></tr><tr><td>Kenya</td><td>2008, 2003, 1998, 1993</td></tr><tr><td>Madagascar</td><td>2008, 2003, 1997, 1992</td></tr><tr><td>Mali</td><td>2001, 1995</td></tr><tr><td>Nepal</td><td>2006, 1996</td></tr><tr><td>Philippines</td><td>2008, 1998, 1993</td></tr><tr><td>Senegal</td><td>2005</td></tr><tr><td>Tanzania</td><td>2004, 1999, 1996</td></tr><tr><td>Turkey</td><td>1998, 1993</td></tr><tr><td>Uganda</td><td>2006, 2000, 1995</td></tr><tr><td>Zambia</td><td>2007, 2001, 1996, 1992</td></tr></table>
<table><tr><td>Country</td><td>Years</td></tr><tr><td>Bangladesh</td><td>1999</td></tr><tr><td>Benin</td><td>2006, 2001, 1996</td></tr><tr><td>Bolivia</td><td>2003, 1998</td></tr><tr><td>Cameroon</td><td>2004, 1998, 1991</td></tr><tr><td>Colombia</td><td>2010, 2005, 2000, 1995</td></tr><tr><td>Dominican republic</td><td>2007, 1999, 1996</td></tr><tr><td>Egypt</td><td>2008, 2005, 2000, 1996</td></tr><tr><td>Ghana</td><td>2008, 2003, 1993</td></tr><tr><td>India</td><td>2005, 1992</td></tr><tr><td>Indonesia</td><td>2007</td></tr><tr><td>Kenya</td><td>2008, 2003, 1998, 1993</td></tr><tr><td>Madagascar</td><td>2008, 2003, 1997, 1992</td></tr><tr><td>Mali</td><td>2001, 1995</td></tr><tr><td>Nepal</td><td>2006, 1996</td></tr><tr><td>Philippines</td><td>2008, 1998, 1993</td></tr><tr><td>Senegal</td><td>2005</td></tr></table>
<table><tr><td>Tanzania</td><td>2004, 1999, 1996</td></tr><tr><td>Turkey</td><td>1998, 1993</td></tr><tr><td>Uganda</td><td>2006, 2000, 1995</td></tr><tr><td>Zambia</td><td>2007, 2001, 1996, 1992</td></tr></table>
9d48145969244573a4a842ceddf2b7b90a190f8026a53b9582cd77df95e561d3.png
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<table><tr><td>Cancer type</td><td>#Patient</td><td>#Gene</td><td>MMF</td><td>AMN</td><td>AMF</td><td>NG</td></tr><tr><td>HNSCC [6]</td><td>74</td><td>4920</td><td>46</td><td>94.5</td><td>1.42</td><td>2</td></tr><tr><td>GBM1 [6]</td><td>84</td><td>178</td><td>43</td><td>9.6</td><td>4.5</td><td>8</td></tr><tr><td>GBM2 [2]</td><td>90</td><td>1126</td><td>48</td><td>21.8</td><td>1.74</td><td>5</td></tr><tr><td>LC [1]</td><td>163</td><td>356</td><td>64</td><td>6.0</td><td>2.75</td><td>4</td></tr><tr><td>OC [2]</td><td>313</td><td>5385</td><td>251</td><td>49.0</td><td>2.85</td><td>101</td></tr></table>
<table><tr><td>Cancer type</td><td>#Patient</td><td>#Gene</td><td>MMF</td><td>AMN</td><td>AMF</td><td>NG</td></tr><tr><td>HNSCC [6]</td><td>74</td><td>4920</td><td>46</td><td>94.5</td><td>1.42</td><td>2</td></tr><tr><td>GBM1 [6]</td><td>84</td><td>178</td><td>43</td><td>9.6</td><td>4.5</td><td>8</td></tr></table>
<table><tr><td>GBM2 [2]</td><td>90</td><td>1126</td><td>48</td><td>21.8</td><td>1.74</td><td>5</td></tr><tr><td>LC [1]</td><td>163</td><td>356</td><td>64</td><td>6.0</td><td>2.75</td><td>4</td></tr><tr><td>OC [2]</td><td>313</td><td>5385</td><td>251</td><td>49.0</td><td>2.85</td><td>101</td></tr></table>
8096c0c04ba94ea95eb4692b25a6385b62dace967c0cb6c3b3413d00930cc607.png
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<table><tr><td>Endpoint</td><td>Exposure conditions</td><td>Results of exposure</td><td>Comments</td><td>Reference</td></tr><tr><td>Weight gain, survival, in SD rats, urinalysis, hematology, blood biochemistry after exposure</td><td>849 MHz CDMA and 1.95 GHz WCDMA, 45 min/day, 5 days/week for 1 year, at 2 W/kg per signal, animals freely moving, am or pm alternately</td><td>No significant effects except significant increase in mean corpuscular hemoglobin level and alkaline phosphatase in males, and significant decrease in total bilirubin and lactate dehydrogenase in females</td><td></td><td>(48)</td></tr><tr><td>Weight gain, survival, lymphoma incidence in AKR/J mice, blood biochemistry after 26 weeks of exposure, metastatic infiltration by IHC</td><td>849 MHz CDMA and 1.95 GHz WCDMA, 45 min/day, 5 days/week for 42 weeks, at 2 W/kg per signal, animals freely moving, am or pm alternately</td><td>No significant effects. Significant decrease in metastatic infiltration in brain of males, increase in females, not due to exposure</td><td></td><td>(49)</td></tr></table>
<table><tr><td>Endpoint</td><td>Exposure conditions</td><td>Results of exposure</td><td>Comments</td><td>Reference</td></tr></table>
<table><tr><td>Weight gain, survival, in SD rats, urinalysis, hematology, blood biochemistry after exposure</td><td>849 MHz CDMA and 1.95 GHz WCDMA, 45 min/day, 5 days/week for 1 year, at 2 W/kg per signal, animals freely moving, am or pm alternately</td><td>No significant effects except significant increase in mean corpuscular hemoglobin level and alkaline phosphatase in males, and significant decrease in total bilirubin and lactate dehydrogenase in females</td><td>(48)</td></tr><tr><td>Weight gain, survival, lymphoma incidence in AKR/J mice, blood biochemistry after 26 weeks of exposure, metastatic infiltration by IHC</td><td>849 MHz CDMA and 1.95 GHz WCDMA, 45 min/day, 5 days/week for 42 weeks, at 2 W/kg per signal, animals freely moving, am or pm alternately</td><td>No significant effects. Significant decrease in metastatic infiltration in brain of males, increase in females, not due to exposure</td><td>(49)</td></tr></table>
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<table><tr><td></td><td>RF</td><td></td><td>GBM</td><td></td><td>KNN</td><td></td><td>SVM</td><td></td></tr><tr><td></td><td>mean</td><td>sd</td><td>mean</td><td>sd</td><td>mean</td><td>sd</td><td>mean</td><td>sd</td></tr><tr><td>ACC</td><td>97,98</td><td>0,12</td><td>97,85</td><td>0,20</td><td>97,43</td><td>0,61</td><td>97,98</td><td>0,12</td></tr><tr><td>Spe</td><td>95,67</td><td>0,84</td><td>95,39</td><td>1,02</td><td>94,63</td><td>2,04</td><td>95,94</td><td>0,65</td></tr><tr><td>Sen</td><td>98,71</td><td>0,11</td><td>98,77</td><td>0,13</td><td>98,33</td><td>0,23</td><td>98,63</td><td>0,25</td></tr><tr><td>Kappa</td><td>94,46</td><td>0,34</td><td>94,09</td><td>0,66</td><td>92,92</td><td>1,72</td><td>94,45</td><td>0,50</td></tr><tr><td>AUC</td><td>97,01</td><td>0,48</td><td>96,65</td><td>0,23</td><td>96,47</td><td>1,10</td><td>97,29</td><td>0,30</td></tr></table>
<table><tr><td></td><td>RF</td><td></td><td>GBM</td><td></td><td>KNN</td><td></td><td>SVM</td><td></td></tr><tr><td></td><td>mean</td><td>sd</td><td>mean</td><td>sd</td><td>mean</td><td>sd</td><td>mean</td><td>sd</td></tr><tr><td>ACC</td><td>97,98</td><td>0,12</td><td>97,85</td><td>0,20</td><td>97,43</td><td>0,61</td><td>97,98</td><td>0,12</td></tr><tr><td>Spe</td><td>95,67</td><td>0,84</td><td>95,39</td><td>1,02</td><td>94,63</td><td>2,04</td><td>95,94</td><td>0,65</td></tr><tr><td>Sen</td><td>98,71</td><td>0,11</td><td>98,77</td><td>0,13</td><td>98,33</td><td>0,23</td><td>98,63</td><td>0,25</td></tr></table>
<table><tr><td></td><td>RF</td><td></td><td>GBM</td><td></td><td>KNN</td><td></td><td>SVM</td><td></td></tr><tr><td></td><td>mean</td><td>sd</td><td>mean</td><td>sd</td><td>mean</td><td>sd</td><td>mean</td><td>sd</td></tr><tr><td>Kappa</td><td>94,46</td><td>0,34</td><td>94,09</td><td>0,66</td><td>92,92</td><td>1,72</td><td>94,45</td><td>0,50</td></tr><tr><td>AUC</td><td>97,01</td><td>0,48</td><td>96,65</td><td>0,23</td><td>96,47</td><td>1,10</td><td>97,29</td><td>0,30</td></tr></table>
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<table><tr><td> </td><td>TJ-54 (<i>n</i> = 48)</td><td>Placebo (<i>n</i> = 50)</td><td>Test statics</td></tr><tr><td>Age (years)</td><td>46.4 &#177; 9.7</td><td>5.4 &#177; 9.6</td><td>ns</td></tr><tr><td>Gender (males/females)</td><td>28/20</td><td>32/18</td><td>ns</td></tr><tr><td>Duration of disease (years)</td><td>23.7 &#177; 10.4</td><td>22.5 &#177; 9.6</td><td>ns</td></tr><tr><td>Duration of treatment (years)</td><td>3.2 &#177; 10.5</td><td>21.0 &#177; 10.3</td><td>ns</td></tr><tr><td>CPZ equivalents (mg)</td><td>1905.8 &#177; 1541.5</td><td>1941.8 &#177; 1948.1</td><td>ns</td></tr><tr><td>Type</td><td> </td><td> </td><td> </td></tr><tr><td>Paranoid</td><td>39</td><td>35</td><td> </td></tr><tr><td> Catatonic</td><td>6</td><td>5</td><td> </td></tr><tr><td> Undifferentiated</td><td>3</td><td>10</td><td>ns</td></tr><tr><td>PANSS (total)</td><td>113.0 &#177; 23.0</td><td>111.1 &#177; 21.1</td><td>ns</td></tr><tr><td>PANSS (positive)</td><td>28.6 &#177; 5.4</td><td>28.7 &#177; 6.0</td><td>ns</td></tr><tr><td>PANSS (negative)</td><td>27.9 &#177; 7.1</td><td>27.8 &#177; 7.3</td><td>ns</td></tr><tr><td>PANSS (general)</td><td>56.6 &#177; 13.3</td><td>54.6 &#177; 11.9</td><td>ns</td></tr><tr><td>CGI-S</td><td>5.4 &#177; 0.8</td><td>5.5 &#177; 0.8</td><td>ns</td></tr><tr><td>GAF</td><td>27.4 &#177; 7.5</td><td>27.2 &#177; 6.4</td><td>ns</td></tr><tr><td>DIEPSS</td><td>4.3 &#177; 4.0</td><td>4.8 &#177; 4.5</td><td>ns</td></tr></table>
<table><tr><td></td><td>TJ-54 (n = 48)</td><td>Placebo (n = 50)</td><td>Test statics</td></tr><tr><td>Age (years)</td><td>46.4 ± 9.7</td><td>5.4 ± 9.6</td><td>ns</td></tr><tr><td>Gender (males/females)</td><td>28/20</td><td>32/18</td><td>ns</td></tr><tr><td>Duration of disease (years)</td><td>23.7 ± 10.4</td><td>22.5 ± 9.6</td><td>ns</td></tr><tr><td>Duration of treatment (years)</td><td>3.2 ± 10.5</td><td>21.0 ± 10.3</td><td>ns</td></tr><tr><td>CPZ equivalents (mg)</td><td>1905.8 ± 1541.5</td><td>1941.8 ± 1948.1</td><td>ns</td></tr><tr><td>Type</td><td></td><td></td><td></td></tr><tr><td>Paranoid</td><td>39</td><td>35</td><td></td></tr><tr><td>Catatonic</td><td>6</td><td>5</td><td></td></tr><tr><td>Undifferentiated</td><td>3</td><td>10</td><td>ns</td></tr><tr><td>PANSS (total)</td><td>113.0 ± 23.0</td><td>111.1 ± 21.1</td><td>ns</td></tr><tr><td>PANSS (positive)</td><td>28.6 ± 5.4</td><td>28.7 ± 6.0</td><td>ns</td></tr><tr><td>PANSS (negative)</td><td>27.9 ± 7.1</td><td>27.8 ± 7.3</td><td>ns</td></tr><tr><td>PANSS (general)</td><td>56.6 ± 13.3</td><td>54.6 ± 11.9</td><td>ns</td></tr><tr><td>CGI-S</td><td>5.4 ± 0.8</td><td>5.5 ± 0.8</td><td>ns</td></tr><tr><td>GAF</td><td>27.4 ± 7.5</td><td>27.2 ± 6.4</td><td>ns</td></tr></table>
<table><tr><td>DIEPSS</td><td>4.3 ± 4.0</td><td>4.8 ± 4.5</td><td>ns</td></tr></table>
ec7188100eedd06d41d158de738f45786fb9858c6bfcb1c22cd11a1e40b5f5e9.png
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<table><tr><td>No.</td><td>Strain</td><td>Species</td><td colspan="2">Culture conditions</td><td>Active acidity</td><td>Bacteriocin production</td></tr><tr><td>S1</td><td>CCDM 731</td><td><i>Lactococcus lactis</i> subsp. <i>Lactis</i></td><td>37&#176;C 18 h</td><td>M17 broth</td><td>4.65</td><td>Nisin</td></tr><tr><td>S2</td><td>CCDM 857</td><td><i>Enterococcus faecalis</i></td><td></td><td>M17 broth</td><td>4.51</td><td>Enterocin</td></tr><tr><td>S3</td><td>CCDM 108</td><td><i>Lactobacillus helveticus</i></td><td></td><td>MRS broth</td><td>4.14</td><td>Enterocin</td></tr><tr><td>S4</td><td>RL 26-P</td><td><i>Lactobacillus plantarum</i></td><td></td><td>MRS broth</td><td>3.67</td><td>Plantaricin</td></tr><tr><td>S5</td><td>CCM 7165</td><td><i>Enterococcus faecium</i></td><td></td><td>M17 broth</td><td>4.68</td><td>Enterocin</td></tr><tr><td>S6</td><td>RL 23-P</td><td><i>Lactobacillus</i> sp.</td><td></td><td>MRS broth</td><td>4.11</td><td>Plantaricin</td></tr><tr><td>S7</td><td>CCDM 768</td><td><i>Lactobacillus helveticus</i></td><td></td><td>MRS broth</td><td>4.07</td><td>Enterocin</td></tr><tr><td>S8</td><td>CCDM 182</td><td><i>Lactobacillus plantarum</i></td><td></td><td>MRS broth</td><td>3.81</td><td>Plantaricin</td></tr><tr><td>S9</td><td>RL 22-P</td><td><i>Lactobacillus gasseri</i></td><td></td><td>MRS broth</td><td>4.51</td><td>Plantaricin</td></tr></table>
<table><tr><td>No.</td><td>Strain</td><td>Species</td><td colspan="2">Culture conditions</td><td>Active acidity</td><td>Bacteriocin production</td></tr><tr><td>S1</td><td>CCDM 731</td><td>Lactococcus lactis subsp. Lactis</td><td>37°C 18 h</td><td>M17 broth</td><td>4.65</td><td>Nisin</td></tr><tr><td>S2</td><td>CCDM 857</td><td>Enterococcus faecalis</td><td></td><td>M17 broth</td><td>4.51</td><td>Enterocin</td></tr><tr><td>S3</td><td>CCDM 108</td><td>Lactobacillus helveticus</td><td></td><td>MRS broth</td><td>4.14</td><td>Enterocin</td></tr><tr><td>S4</td><td>RL 26-P</td><td>Lactobacillus plantarum</td><td></td><td>MRS broth</td><td>3.67</td><td>Plantaricin</td></tr><tr><td>S5</td><td>CCM 7165</td><td>Enterococcus faecium</td><td></td><td>M17 broth</td><td>4.68</td><td>Enterocin</td></tr><tr><td>S6</td><td>RL 23-P</td><td>Lactobacillus sp.</td><td></td><td>MRS broth</td><td>4.11</td><td>Plantaricin</td></tr><tr><td>S7</td><td></td><td>Lactoba</td><td></td><td>MRS broth</td><td>4.</td><td>Ent</td></tr></table>
<table><tr><td>No.</td><td>Strain</td><td>Species</td><td>Culture conditions</td><td>Active acidity</td><td>Bacteriocin production</td></tr><tr><td></td><td>CCDM 768</td><td>cillus helveticus</td><td></td><td>07</td><td>erocin</td></tr><tr><td>S8</td><td>CCDM 182</td><td>Lactobacillus plantarum</td><td>MRS broth</td><td>3.81</td><td>Plantaricin</td></tr><tr><td>S9</td><td>RL 22-P</td><td>Lactobacillus gasseri</td><td>MRS broth</td><td>4.51</td><td>Plantaricin</td></tr></table>
a922c919f237199607d1c283dac3b49eaf4224adafa285d9cf282d3861905c50.png
simple
<table><tr><td>Cross</td><td>Generation</td><td>No. of total plants</td><td>No. of dwarf plants (&lt; 60 cm)</td><td>No. of high plants (&#8805;60 cm)</td><td>&#967;<sup>2 </sup>(1:1)</td></tr><tr><td>(Huaai11/Monker)/Huaai 11</td><td>BC1</td><td>135</td><td>62</td><td>73</td><td>0.90</td></tr><tr><td>(Huaai11/Monker)/Aiganqi</td><td>TC1</td><td>119</td><td>0</td><td>119</td><td>0</td></tr><tr><td>(Huaai 11/Monker)/Himalaya</td><td>TC1</td><td>157</td><td>0</td><td>157</td><td>0</td></tr><tr><td>(Huaai 11/Monker)/Indian dwarf</td><td>TC1</td><td>117</td><td>0</td><td>117</td><td>0</td></tr><tr><td>(Huaai 11/Monker)/Maris Mink</td><td>TC1</td><td>143</td><td>0</td><td>143</td><td>0</td></tr></table>
<table><tr><td>Cross</td><td>Generation</td><td>No. of total plants</td><td>No. of dwarf plants (< 60 cm)</td><td>No. of high plants (≥60 cm)</td><td>χ2 (1:1)</td></tr><tr><td>(Huaai11/Monker)/Huaai 11</td><td>BC1</td><td>135</td><td>62</td><td>73</td><td>0.90</td></tr><tr><td>(Huaai11/Monker)/Aiganqi</td><td>TC1</td><td>119</td><td>0</td><td>119</td><td>0</td></tr></table>
<table><tr><td>(Huaai 11/Monker)/Himalaya</td><td>TC1</td><td>157</td><td>0</td><td>157</td><td>0</td></tr><tr><td>(Huaai 11/Monker)/Indian dwarf</td><td>TC1</td><td>117</td><td>0</td><td>117</td><td>0</td></tr><tr><td>(Huaai 11/Monker)/Maris Mink</td><td>TC1</td><td>143</td><td>0</td><td>143</td><td>0</td></tr></table>
bbb8b1caceb4855aadf32980ca3bbdb042fa99084f16a5491d22488a50a5ac54.png
simple
<table><tr><td>Rat Number</td><td>Treatment</td><td>Hemisphere</td><td>Frequency (kHz)</td><td>Voltage (V)</td></tr><tr><td>1</td><td>IRE</td><td>Left</td><td>-</td><td>100</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>250</td><td>100</td></tr><tr><td>2</td><td>IRE</td><td>Left</td><td>-</td><td>200</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>250</td><td>200</td></tr><tr><td>3</td><td>H-FIRE</td><td>Left</td><td>250</td><td>300</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>250</td><td>400</td></tr><tr><td>4</td><td>IRE</td><td>Left</td><td>-</td><td>50</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>500</td><td>400</td></tr></table>
<table><tr><td>Rat Number</td><td>Treatment</td><td>Hemisphere</td><td>Frequency (kHz)</td><td>Voltage (V)</td></tr><tr><td>1</td><td>IRE</td><td>Left</td><td>-</td><td>100</td></tr></table>
<table><tr><td>Rat Number</td><td>Treatment</td><td>Hemisphere</td><td>Frequency (kHz)</td><td>Voltage (V)</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>250</td><td>100</td></tr><tr><td>2</td><td>IRE</td><td>Left</td><td>-</td><td>200</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>250</td><td>200</td></tr><tr><td>3</td><td>H-FIRE</td><td>Left</td><td>250</td><td>300</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>250</td><td>400</td></tr><tr><td>4</td><td>IRE</td><td>Left</td><td>-</td><td>50</td></tr><tr><td></td><td>H-FIRE</td><td>Right</td><td>500</td><td>400</td></tr></table>
4fb0080b6d4c1e703d09c59e810fe2d9b4be5d0f64cbe183cb70cd6ee2fe3027.png
simple
<table><tr><td></td><td>Standard of care (SOC)</td><td>Community-based intervention (CBI)</td></tr><tr><td>Adult patients asked to bring child contacts to TB clinic for screening</td><td>X</td><td>X</td></tr><tr><td>Child contacts screened with symptom questionnaire</td><td>X</td><td>X</td></tr><tr><td>IPT offered to eligible child contacts</td><td>X</td><td>X</td></tr><tr><td>Monthly IPT visits</td><td>X</td><td>X</td></tr><tr><td>HIV testing encouraged for eligible child contacts</td><td>X</td><td>X</td></tr><tr><td>Active community contact tracing</td><td></td><td>X</td></tr><tr><td>Community-based health education using study brochure</td><td></td><td>X</td></tr><tr><td>Child screening and IPT provision according to clinical algorithm</td><td></td><td>X</td></tr><tr><td>Nurse training and ongoing mentorship</td><td></td><td>X</td></tr><tr><td>Health education for caregivers using treatment literacy curriculum</td><td></td><td>X</td></tr><tr><td>Active tracking of IPT provision</td><td></td><td>X</td></tr><tr><td>Consistent community support via VHW</td><td></td><td>X</td></tr><tr><td>Social support and navigation by VHW</td><td></td><td>X</td></tr><tr><td>SMS medication and appointment reminder messages</td><td></td><td>X</td></tr><tr><td>Review of IPT monitoring data at quarterly multidisciplinary team meetings</td><td></td><td>X</td></tr></table>
<table><tr><td></td><td>Standard of care (SOC)</td><td>Community-based intervention (CBI)</td></tr><tr><td>Adult patients asked to bring child contacts to TB clinic for screening</td><td>X</td><td>X</td></tr><tr><td>Child contacts screened with symptom questionnaire</td><td>X</td><td>X</td></tr><tr><td>IPT offered to eligible child contacts</td><td>X</td><td>X</td></tr><tr><td>Monthly IPT visits</td><td>X</td><td>X</td></tr><tr><td>HIV testing encouraged for eligible child contacts</td><td>X</td><td>X</td></tr><tr><td>Active community contact tracing</td><td></td><td>X</td></tr><tr><td>Community-based health education using study brochure</td><td></td><td>X</td></tr><tr><td>Child screening and IPT provision according to clinical algorithm</td><td></td><td>X</td></tr><tr><td>Nurse training and ongoing mentorship</td><td></td><td>X</td></tr></table>
<table><tr><td>Health education for caregivers using treatment literacy curriculum</td><td>X</td></tr><tr><td>Active tracking of IPT provision</td><td>X</td></tr><tr><td>Consistent community support via VHW</td><td>X</td></tr><tr><td>Social support and navigation by VHW</td><td>X</td></tr><tr><td>SMS medication and appointment reminder messages</td><td>X</td></tr><tr><td>Review of IPT monitoring data at quarterly multidisciplinary team meetings</td><td>X</td></tr></table>
48c6461913701fd6a84145cf78a5486eeac4990384998aa840c31a3b149f540f.png
simple
<table><tr><td>Socio-Demographic Characteristics</td><td>Total <i>n</i> = 60</td></tr><tr><td>Age Range (Min, max)</td><td>70&#8211;97</td></tr><tr><td>Mean (SD)</td><td>77 (6.27)</td></tr><tr><td>Sex, <i>n</i> (%)</td><td></td></tr><tr><td>Female</td><td>40 (66.7)</td></tr><tr><td>Male</td><td>20 (33.3)</td></tr><tr><td>Educational Level, <i>n</i> (%)</td><td></td></tr><tr><td>High school or less</td><td>48 (80)</td></tr><tr><td>Some college education</td><td>12 (20)</td></tr><tr><td>Monthly Income, <i>n</i> (%)</td><td></td></tr><tr><td>Low(&lt;$1000)</td><td>50 (83)</td></tr><tr><td>Medium ($1000&#8211;$2000)</td><td>8 (13)</td></tr><tr><td>High (&gt;$2000)</td><td>2 (3)</td></tr><tr><td>Health Conditions, <i>n</i> (%)</td><td></td></tr><tr><td>Hypertension</td><td>35 (58)</td></tr><tr><td>Musculoskeletal</td><td>33 (55)</td></tr><tr><td>Diabetes</td><td>32 (53)</td></tr><tr><td>Visual</td><td>15 (25)</td></tr><tr><td>Respiratory</td><td>13 (23)</td></tr><tr><td>Cardiac</td><td>12 (20)</td></tr><tr><td>Overweight</td><td>12 (20)</td></tr></table>
<table><tr><td>Socio-Demographic Characteristics</td><td>Total n = 60</td></tr><tr><td>Age Range (Min, max)</td><td>70–97</td></tr><tr><td>Mean (SD)</td><td>77 (6.27)</td></tr><tr><td>Sex, n (%)</td><td></td></tr><tr><td>Female</td><td>40 (66.7)</td></tr><tr><td>Male</td><td>20 (33.3)</td></tr><tr><td>Educational Level, n (%)</td><td></td></tr><tr><td>High school or less</td><td>48 (80)</td></tr><tr><td>Some college education</td><td>12 (20)</td></tr><tr><td>Monthly Income, n (%)</td><td></td></tr><tr><td>Low(<$1000)</td><td>50 (83)</td></tr><tr><td>Medium ($1000–$2000)</td><td>8 (13)</td></tr><tr><td>High (>$2000)</td><td>2 (3)</td></tr><tr><td>Health Conditions, n (%)</td><td></td></tr><tr><td>Hypertension</td><td>35 (58)</td></tr><tr><td>Musculoskeletal</td><td>33 (55)</td></tr><tr><td>Diabetes</td><td>32 (53)</td></tr><tr><td>Visual</td><td>15 (25)</td></tr><tr><td>Respiratory</td><td>13 (23)</td></tr></table>
<table><tr><td>Socio-Demographic Characteristics</td><td>Total n = 60</td></tr><tr><td>Cardiac</td><td>12 (20)</td></tr><tr><td>Overweight</td><td>12 (20)</td></tr></table>
a2634c1a5cb624fe7524edf01b78b59e91c758ad810d52fa928c28f1108a2542.png
complex
<table><tr><td rowspan="3"></td><td>3-month mRS 0&#8211;2 in all patients (<i>n</i> = 646)</td><td>3-month mRS 0&#8211;2 in rtPA patients (<i>n</i> = 376)</td></tr><tr><td><i>R</i><sup>2</sup> (coefficient, <i>p</i>)</td><td><i>R</i><sup>2</sup> (coefficient, <i>p</i>)</td></tr><tr><td>Time to CT (h)</td><td>0.058 (0.081, <i>p</i> = 0.009)</td><td>0.099 (0.131, <i>p</i> = 0.002)</td></tr><tr><td>Time to treatment</td><td></td><td>0.096 (0.137, <i>p</i> = 0.01)</td></tr><tr><td>Acute NIHSS</td><td>0.203 (0.119, <i>p</i> &lt; 0.001)</td><td>0.116 (0.161, <i>p</i> &lt; 0.001)</td></tr><tr><td>Diabetes</td><td>0.001 (0.011, <i>p</i> = 0.904)</td><td>0.009 (0.027, <i>p</i> &lt; 0.001)</td></tr><tr><td>Age</td><td>0.027 (0.079, <i>p</i> = 0.013)</td><td>0.019 (0.154, <i>p</i> &lt; 0.001)</td></tr><tr><td>Hypertension</td><td>0.002 (0.021, <i>p</i> = 0.238)</td><td>0.018 (0.018, <i>p</i> = 0.181)</td></tr><tr><td>Smoker</td><td>0.001 (0.019, <i>p</i> = 0.446)</td><td>0.001 (0.007, <i>p</i> = 0.417)</td></tr><tr><td>AF</td><td>0.001 (0.091, <i>p</i> = 0.451)</td><td>0.001 (0.108, <i>p</i> = 0.538)</td></tr><tr><td>Lipids</td><td>0.001 (0.014, <i>p</i> = 0.741)</td><td>0.001 (0.027, <i>p</i> = 0.461)</td></tr></table>
<table><tr><td rowspan="3"></td></tr><tr></tr><tr></tr><tr><td>Time to CT (h)</td></tr><tr><td>Time to treatment</td></tr><tr><td>Acute NIHSS</td></tr><tr><td>Diabetes</td></tr><tr><td>Age</td></tr><tr><td>Hypertension</td></tr><tr><td>Smoker</td></tr><tr><td>AF</td></tr><tr><td>Lipids</td></tr></table>
<table><tr><td>3-month mRS 0–2 in all patients (n = 646)</td><td>3-month mRS 0–2 in rtPA patients (n = 376)</td></tr><tr><td>R2 (coefficient, p)</td><td>R2 (coefficient, p)</td></tr><tr><td colspan="2"></td></tr><tr><td>0.058 (0.081, p = 0.009)</td><td>0.099 (0.131, p = 0.002)</td></tr><tr><td></td><td>0.096 (0.137, p = 0.01)</td></tr><tr><td>0.203 (0.119, p < 0.001)</td><td>0.116 (0.161, p < 0.001)</td></tr><tr><td>0.001 (0.011, p = 0.904)</td><td>0.009 (0.027, p < 0.001)</td></tr><tr><td>0.027 (0.079, p = 0.013)</td><td>0.019 (0.154, p < 0.001)</td></tr><tr><td>0.002 (0.021, p = 0.238)</td><td>0.018 (0.018, p = 0.181)</td></tr><tr><td>0.001 (0.019, p = 0.446)</td><td>0.001 (0.007, p = 0.417)</td></tr><tr><td>0.001 (0.091, p = 0.451)</td><td>0.001 (0.108, p = 0.538)</td></tr><tr><td>0.001 (0.014, p = 0.741)</td><td>0.001 (0.027, p = 0.461)</td></tr></table>
0d37153175a0567f7a8f4d8e74b73fca4b06ae62dfe5034e1293cebcd0ac4a80.png
complex
<table><tr><td colspan="2">Gene Contributes to Core Enrichment</td><td colspan="3">Gene Does Not Contribute to Core Enrichment</td></tr><tr><td>BMP4</td><td>SP1</td><td>ACTB</td><td>GJA1</td><td>PDPK1</td></tr><tr><td>BMP6</td><td>TBXAS1</td><td>AKAP1</td><td>GNAS</td><td>PECAM1</td></tr><tr><td>CCL2</td><td>TGFB1</td><td>ANXA2</td><td>GNB2</td><td>PFDN5</td></tr><tr><td><i>CD34</i></td><td><i>THBD</i></td><td><i>ANXA5</i></td><td><i>GNG5</i></td><td><i>PTGS2</i></td></tr><tr><td><i>CENPF</i></td><td><i>THBS1</i></td><td><i>APOE</i></td><td><i>GRN</i></td><td><i>RGS5</i></td></tr><tr><td><i>CTGF</i></td><td><i>TRA1</i></td><td><i>APS</i></td><td><i>HADHSC</i></td><td><i>RPL30</i></td></tr><tr><td><i>CXCL12</i></td><td><i>TUBG1</i></td><td><i>ARF4L</i></td><td><i>HMOX1</i></td><td><i>RPL34</i></td></tr><tr><td><i>CYP1B1</i></td><td><i>VCAM1</i></td><td><i>ASS</i></td><td><i>ICAM1</i></td><td><i>RPS11</i></td></tr><tr><td><i>CYR61</i></td><td><i>VIPR1</i></td><td><i>CAV1</i></td><td><i>IFITM3</i></td><td><i>RPS7</i></td></tr><tr><td><i>DPYSL3</i></td><td><i>XPO1</i></td><td><i>CCL15</i></td><td><i>IL13RA1</i></td><td><i>SAT</i></td></tr><tr><td><i>EDN1</i></td><td></td><td><i>CCL25</i></td><td><i>IL15</i></td><td><i>SCGF</i></td></tr><tr><td><i>EEF1A2</i></td><td></td><td><i>CD164</i></td><td><i>IL16</i></td><td><i>SELE</i></td></tr><tr><td><i>ELN</i></td><td></td><td><i>CD1D</i></td><td><i>IL1R1</i></td><td><i>SERPINE1</i></td></tr><tr><td><i>F3</i></td><td></td><td><i>CD58</i></td><td><i>IL1RL1</i></td><td><i>SERPINE2</i></td></tr><tr><td><i>FGF2</i></td><td></td><td><i>CD68</i></td><td><i>ITGB3</i></td><td><i>SLC35F2</i></td></tr><tr><td><i>FN1</i></td><td></td><td><i>CDKN1A</i></td><td><i>JARID1A</i></td><td><i>SMARCD1</i></td></tr><tr><td><i>GAPD</i></td><td></td><td><i>CEACAM1</i></td><td><i>JUN</i></td><td><i>SOD2</i></td></tr><tr><td><i>GBP1</i></td><td></td><td><i>CYP1A1</i></td><td><i>KLF2</i></td><td><i>SPARC</i></td></tr><tr><td><i>GJA5</i></td><td></td><td><i>DKK2</i></td><td><i>LAMB1</i></td><td><i>SPTA1</i></td></tr><tr><td><i>GSTP1</i></td><td></td><td><i>E2F5</i></td><td><i>LIMS1</i></td><td><i>SPTAN1</i></td></tr><tr><td><i>IL8</i></td><td></td><td><i>EDN3</i></td><td><i>LRP2</i></td><td><i>STAM</i></td></tr><tr><td><i>ILK</i></td><td></td><td><i>EFEMP1</i></td><td><i>METAP2</i></td><td><i>TEK</i></td></tr><tr><td><i>JAG2</i></td><td></td><td><i>EGR1</i></td><td><i>MGP</i></td><td><i>TFPI</i></td></tr><tr><td><i>JUNB</i></td><td></td><td><i>EIF4EBP2</i></td><td><i>MMP1</i></td><td><i>TGFB1I4</i></td></tr><tr><td><i>KIF20A</i></td><td></td><td><i>EIF4G3</i></td><td><i>MMP14</i></td><td><i>THBS4</i></td></tr><tr><td><i>KLF4</i></td><td></td><td><i>ESM1</i></td><td><i>MMRN1</i></td><td><i>TNFRSF1A</i></td></tr><tr><td><i>LIG3</i></td><td></td><td><i>F2</i></td><td><i>MYD88</i></td><td><i>TNFRSF5</i></td></tr><tr><td><i>MAPRE1</i></td><td></td><td><i>F2R</i></td><td><i>NFKB1</i></td><td><i>TNFSF8</i></td></tr><tr><td><i>MATN2</i></td><td></td><td><i>FGF6</i></td><td><i>NOTCH4</i></td><td><i>TUBA3</i></td></tr><tr><td><i>MYC</i></td><td></td><td><i>FGFR3</i></td><td><i>NQO1</i></td><td><i>TXNRD1</i></td></tr><tr><td><i>NOS3</i></td><td></td><td><i>FLT1</i></td><td><i>NUMA1</i></td><td><i>UNG</i></td></tr><tr><td><i>PFDN2</i></td><td></td><td><i>FOS</i></td><td><i>OGT</i></td><td><i>VCL</i></td></tr><tr><td><i>PLAT</i></td><td></td><td><i>FOSL1</i></td><td><i>OLR1</i></td><td><i>VEGFC</i></td></tr><tr><td><i>RGS3</i></td><td></td><td><i>FTH1</i></td><td><i>PBP</i></td><td><i>VWF</i></td></tr><tr><td><i>RHOA</i></td><td></td><td><i>FTL</i></td><td><i>PCQAP</i></td><td><i>WNT2B</i></td></tr><tr><td><i>RHOB</i></td><td></td><td><i>GARS</i></td><td><i>PDGFRA</i></td><td></td></tr><tr><td><i>S100A10</i></td><td></td><td><i>GAS</i></td><td><i>PDGFRB</i></td><td></td></tr></table>
<table><tr><td colspan="2">Gene Contributes to Core Enrichment</td><td colspan="3">Gene Does Not Contribute to Core Enrichment</td></tr><tr><td>BMP4</td><td>SP1</td><td>ACTB</td><td>GJA1</td><td>PDPK1</td></tr><tr><td>BMP6</td><td>TBXAS1</td><td>AKAP1</td><td>GNAS</td><td>PECAM1</td></tr><tr><td>CCL2</td><td>TGFB1</td><td>ANXA2</td><td>GNB2</td><td>PFDN5</td></tr><tr><td>CD34</td><td>THBD</td><td>ANXA5</td><td>GNG5</td><td>PTGS2</td></tr><tr><td>CENPF</td><td>THBS1</td><td>APOE</td><td>GRN</td><td>RGS5</td></tr><tr><td>CTGF</td><td>TRA1</td><td>APS</td><td>HADHSC</td><td>RPL30</td></tr><tr><td>CXCL12</td><td>TUBG1</td><td>ARF4L</td><td>HMOX1</td><td>RPL34</td></tr><tr><td>CYP1B1</td><td>VCAM1</td><td>ASS</td><td>ICAM1</td><td>RPS11</td></tr></table>
<table><tr><td>CYR61</td><td>VIPR1</td><td>CAV1</td><td>IFITM3</td><td>RPS7</td></tr><tr><td>DPYSL3</td><td>XPO1</td><td>CCL15</td><td>IL13RA1</td><td>SAT</td></tr><tr><td>EDN1</td><td></td><td>CCL25</td><td>IL15</td><td>SCGF</td></tr><tr><td>EEF1A2</td><td></td><td>CD164</td><td>IL16</td><td>SELE</td></tr><tr><td>ELN</td><td></td><td>CD1D</td><td>IL1R1</td><td>SERPINE1</td></tr><tr><td>F3</td><td></td><td>CD58</td><td>IL1RL1</td><td>SERPINE2</td></tr><tr><td>FGF2</td><td></td><td>CD68</td><td>ITGB3</td><td>SLC35F2</td></tr><tr><td>FN1</td><td></td><td>CDKN1A</td><td>JARID1A</td><td>SMARCD1</td></tr><tr><td>GAPD</td><td></td><td>CEACAM1</td><td>JUN</td><td>SOD2</td></tr><tr><td>GBP1</td><td></td><td>CYP1A1</td><td>KLF2</td><td>SPARC</td></tr><tr><td>GJA5</td><td></td><td>DKK2</td><td>LAMB1</td><td>SPTA1</td></tr><tr><td>GSTP1</td><td></td><td>E2F5</td><td>LIMS1</td><td>SPTAN1</td></tr><tr><td>IL8</td><td></td><td>EDN3</td><td>LRP2</td><td>STAM</td></tr><tr><td>ILK</td><td></td><td>EFEMP1</td><td>METAP2</td><td>TEK</td></tr><tr><td>JAG2</td><td></td><td>EGR1</td><td>MGP</td><td>TFPI</td></tr><tr><td>JUNB</td><td></td><td>EIF4EBP2</td><td>MMP1</td><td>TGFB1I4</td></tr><tr><td>KIF20A</td><td></td><td>EIF4G3</td><td>MMP14</td><td>THBS4</td></tr><tr><td>KLF4</td><td></td><td>ESM1</td><td>MMRN1</td><td>TNFRSF1A</td></tr><tr><td>LIG3</td><td></td><td>F2</td><td>MYD88</td><td>TNFRSF5</td></tr><tr><td>MAPRE1</td><td></td><td>F2R</td><td>NFKB1</td><td>TNFSF8</td></tr><tr><td>MATN2</td><td></td><td>FGF6</td><td>NOTCH4</td><td>TUBA3</td></tr><tr><td>MYC</td><td></td><td>FGFR3</td><td>NQO1</td><td>TXNRD1</td></tr><tr><td>NOS3</td><td></td><td>FLT1</td><td>NUMA1</td><td>UNG</td></tr><tr><td>PFDN2</td><td></td><td>FOS</td><td>OGT</td><td>VCL</td></tr><tr><td>PLAT</td><td></td><td>FOSL1</td><td>OLR1</td><td>VEGFC</td></tr><tr><td>RGS3</td><td></td><td>FTH1</td><td>PBP</td><td>VWF</td></tr><tr><td>RHOA</td><td></td><td>FTL</td><td>PCQAP</td><td>WNT2B</td></tr><tr><td>RHOB</td><td></td><td>GARS</td><td>PDGFRA</td><td></td></tr><tr><td>S100A10</td><td></td><td>GAS</td><td>PDGFRB</td><td></td></tr></table>
6ae8b8be24d52229a0519a944b0e12e78980aeb6433734554ccbd086cea9fe42.png
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<table><tr><td colspan="5">VSSinitial</td><td colspan="4">VSSmax</td></tr><tr><td></td><td>Chi-square</td><td>OR</td><td>95% CI</td><td><i>P</i></td><td>Chi-square</td><td>OR</td><td>95% CI</td><td><i>P</i></td></tr><tr><td>VSS 0/1</td><td>94.31</td><td>4.10</td><td>3.03 to 5.54</td><td>&lt;0.0001</td><td>65.7</td><td>3.45</td><td>2.54 to 4.77</td><td>&lt;0.0001</td></tr><tr><td>VSS 1/2</td><td>11.32</td><td>2.11</td><td>1.38 to 3.23</td><td>0.0008</td><td>0.89</td><td>1.22</td><td>0.84 to 1.76</td><td>0.35</td></tr><tr><td>VSS 2/3</td><td>13.04</td><td>3.21</td><td>1.73 to 5.97</td><td>0.0003</td><td>23.23</td><td>3.63</td><td>2.14 to 6.17</td><td>&lt;0.0001</td></tr><tr><td>VSS 3/4</td><td>0.01</td><td>1.029</td><td>0.48 to 2.22</td><td>0.94</td><td>8.90</td><td>2.95</td><td>1.50 to 5.81</td><td>0.0029</td></tr></table>
<table><tr><td colspan="5">VSSinitial</td><td colspan="4">VSSmax</td></tr><tr><td></td><td>Chi-square</td><td>OR</td><td>95% CI</td><td>P</td><td>Chi-square</td><td>OR</td><td>95% CI</td><td>P</td></tr><tr><td>VSS 0/1</td><td>94.31</td><td>4.10</td><td>3.03 to 5.54</td><td><0.0001</td><td>65.7</td><td>3.45</td><td>2.54 to 4.77</td><td><0.0001</td></tr><tr><td>VSS 1/2</td><td>11.32</td><td>2.11</td><td>1.38 to 3.23</td><td>0.0008</td><td>0.89</td><td>1.22</td><td>0.84 to 1.76</td><td>0.35</td></tr><tr><td>VSS 2/3</td><td>13.04</td><td>3.21</td><td>1.73 to 5.97</td><td>0.0003</td><td>23.23</td><td>3.63</td><td>2.14 to 6.17</td><td><0.0001</td></tr><tr><td>VSS 3/</td><td>0.01</td><td>1.0</td><td>0.4</td><td></td><td>8.90</td><td>2.</td><td>1.50</td><td>0.0029</td></tr></table>
<table><tr><td colspan="4">VSSinitial</td><td colspan="2">VSSmax</td></tr><tr><td></td><td>OR</td><td>95% CI</td><td>P</td><td>OR</td><td>95% CI</td></tr><tr><td>4</td><td>29</td><td>8 to 2.22</td><td>0.94</td><td>95</td><td> to 5.81</td></tr></table>
e2d7587b1866a2f88aa90d0cd09f421c6b4af4fd9d32a2fb3ddbaa114f954bb8.png
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<table><tr><td>Study</td><td>Adequate sequence generated?</td><td>Allocation concealment?</td><td>Blinding of participants and personnel?</td><td>Blinding of viral load assessment?</td><td>Incomplete outcome data addressed? (Missing at follow up = treatment failure)</td><td>Free of other bias?</td></tr><tr><td rowspan="2">Jaffar et al. [37]</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Yes.</td><td>No.</td><td>Yes.</td></tr><tr><td>Cards were sealed in advance and labelled with stratum numbers and placed into a box</td><td>Sealed cards were drawn from a concealed box.</td><td>The study was cluster randomized trial; researchers and participants knew which clusters were receiving the interventions.</td><td>Probably done, because Blood taken for viral load testing was for research purposes; the testing was done in batches rather than in real-time.</td><td>&#8220;Those who withdrew or were lost to follow-up before 12 months were excluded from the primary endpoint analysis...&#8221;</td><td>The two groups were well balanced according to baseline characteristics apart from CD4-cell count, which was lower in the home-based than in the facility-based group [39]. There were no losses of clusters. The analysis adjusted for the effect clustering</td></tr><tr><td rowspan="2">Nachega et al. [35]</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Unclear.</td><td>Yes.</td><td>No.</td></tr><tr><td>Probably done, because there was sequential allocation concealment</td><td>&#8220;[T]reatment assignments were placed in opaque envelopes, which were sequentially opened by the study coordinator at enrolment.&#8221;</td><td>The study was an open-label, randomized controlled trial; both the researchers and the participants knew which intervention was being administered.</td><td>Measurement of viral loads performed was every 6 months as part of routine monitoring</td><td>Missing viral load values were considered detectable.</td><td>Trial terminated early for futility by an independent Data and Safety Monitoring Board</td></tr><tr><td rowspan="2">Chang et al. [38]</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Unclear.</td><td>No.</td><td>No.</td></tr><tr><td>An allocation sequence was generated</td><td>Random allocation was by drawing of lots.</td><td>The study was cluster randomized trial; researchers and participants knew which clusters were receiving the interventions.</td><td>"Viral loads ... were performed every 24 weeks on all patients as part of routine patient monitoring procedures."</td><td>Those who died or were lost to follow-up were excluded from the analysis of shorter-term virologic outcomes</td><td>Contamination in the control arm was reported in subsequent evaluation study [40].</td></tr><tr><td rowspan="2">Taiwo et al. [36]</td><td>Yes.</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Yes.</td><td>Yes.</td></tr><tr><td>&#8220;Using a computer-generated allocation sequence, randomization was performed ...&#8221;</td><td>Probably done, because there was computer-generated allocation sequence.</td><td>&#8220;The study pharmacist, who was blinded to treatment arm, provided one-on-one reinforcement of the education provided by the adherence counsellor plus information specific to each participant&#8217;s regimen.&#8221;</td><td>Probably not done because patients who had detectable viral loads at week 24 underwent intensive adherence retraining with the adherence counsellor.</td><td>&#8220;[P]articipants who were missing virologic indicators and were reported to have died were counted as failures.&#8221;</td><td>There were no significant differences between treatment groups at baseline.</td></tr><tr><td rowspan="2">Matovu et al. [17]</td><td>Yes.</td><td>Unclear.</td><td>No.</td><td>Unclear.</td><td>No.</td><td>No.</td></tr><tr><td>Probably done, because patients were randomly allocated.</td><td>Insufficient information to permit judgement of &#8220;Yes&#8221; or &#8220;No&#8221;.</td><td>The study was an open randomized non-inferiority intervention trial.</td><td>Insufficient information to permit judgement of &#8220;Yes&#8221; or &#8220;No&#8221;.</td><td>Patients lost to follow-up were excluded from the analysis.</td><td>Baseline viral load was adjusted for. This means there were significant differences in viral loads between intervention groups at baseline.</td></tr></table>
<table><tr><td>Study</td><td>Adequate sequence generated?</td><td>Allocation concealment?</td><td>Blinding of participants and personnel?</td><td>Blinding of viral load assessment?</td><td>Incomplete outcome data addressed? (Missing at follow up = treatment failure)</td><td>Free of other bias?</td></tr><tr><td rowspan="2">Jaffar et al. [37]</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Yes.</td><td>No.</td><td>Yes.</td></tr><tr><td>Cards were sealed in advance and labelled with stratum numbers and placed into a box</td><td>Sealed cards were drawn from a concealed box.</td><td>The study was cluster randomized trial; researchers and participants knew which clusters were receiving the interventions.</td><td>Probably done, because Blood taken for viral load testing was for research purposes; the testing was done in batches rather than in real-time.</td><td>“Those who withdrew or were lost to follow-up before 12 months were excluded from the primary endpoint analysis...”</td><td>The two groups were well balanced according to baseline characteristics apart from CD4-cell count, which was lower in the home-based than in the facility-based group [39]. There were no losses of clusters. The analysis adjusted for the effect clustering</td></tr><tr><td rowspan="2">Nachega et al. [35]</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Unclear.</td><td>Yes.</td><td>No.</td></tr><tr><td>Probably done, because there was sequential allocation concealment</td><td>“[T]reatment assignments were placed in opaque envelopes, which were sequentially opened by the study coordinator at enrolment.”</td><td>The study was an open-label, randomized controlled trial; both the researchers and the participants knew which intervention was being administered.</td><td>Measurement of viral loads performed was every 6 months as part of routine monitoring</td><td>Missing viral load values were considered detectable.</td><td>Trial terminated early for futility by an independent Data and Safety Monitoring Board</td></tr><tr><td rowspan="2">Chang et al. [38]</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Unclear.</td><td>No.</td><td>No.</td></tr><tr><td>An allocation sequence was generated</td><td>Random allocation was by drawing of lots.</td><td>The study was cluster randomized trial; researchers and participants knew which clusters were receiving the interventions.</td><td>"Viral loads ... were performed every 24 weeks on all patients as part of routine patient monitoring procedures."</td><td>Those who died or were lost to follow-up were excluded from the analysis of shorter-term virologic outcomes</td><td>Contamination in the control arm was reported in subsequent evaluation study [40].</td></tr><tr><td rowspan="2">Taiwo et al. [36]</td><td>Yes.</td><td>Yes.</td><td>Yes.</td><td>No.</td><td>Yes.</td><td>Yes.</td></tr><tr><td>“Using a computer-generated allocation sequence, randomization was performed ...”</td><td>Probably done, because there was computer-generated allocation sequence.</td><td>“The study pharmacist, who was blinded to treatment arm, provided one-on-one reinforcement of the education provided by the adherence counsellor plus information specific to each participant’s regimen.”</td><td>Probably not done because patients who had detectable viral loads at week 24 underwent intensive adherence retraining with the adherence counsellor.</td><td>“[P]articipants who were missing virologic indicators and were reported to have died were counted as failures.”</td><td>There were no significant differences between treatment groups at baseline.</td></tr><tr><td>Matovu et al. [17]</td><td>Yes.</td><td>Unclear.</td><td>No.</td><td>Unclear.</td><td>No.</td><td>No.</td></tr></table>
<table><tr><td>Matovu et al. [17]</td><td>Probably done, because patients were randomly allocated.</td><td>Insufficient information to permit judgement of “Yes” or “No”.</td><td>The study was an open randomized non-inferiority intervention trial.</td><td>Insufficient information to permit judgement of “Yes” or “No”.</td><td>Patients lost to follow-up were excluded from the analysis.</td><td>Baseline viral load was adjusted for. This means there were significant differences in viral loads between intervention groups at baseline.</td></tr></table>
42577870cd834fa383a45345c1cf4ece9bef21f6ae072383d50809c465759556.png
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<table><tr><td>Variable</td><td>Male (n=12)</td><td>Female (n=8)</td></tr><tr><td colspan="3">Age (years)</td></tr><tr><td> Mean</td><td>63.50</td><td>73.38</td></tr><tr><td> Range</td><td>21&#8211;80</td><td>63&#8211;87</td></tr><tr><td> Minimum (%)</td><td>21 (12.5)</td><td>63 (25.0)</td></tr><tr><td> Maximum (%)</td><td>80 (12.5)</td><td>87 (37.5)</td></tr><tr><td colspan="3">Grade of differentiation (n)</td></tr><tr><td> IIB (%)</td><td>1 (8.3)</td><td>0 (0)</td></tr><tr><td> IIC (%)</td><td>1 (8.3)</td><td>0 (0)</td></tr><tr><td> IIIB (%)</td><td>1 (8.3)</td><td>2 (25.0)</td></tr><tr><td> IIIA (%)</td><td>1 (8.3)</td><td>1 (12.5)</td></tr><tr><td>Colon (%)</td><td>9 (75.0)</td><td>4 (50.0)</td></tr><tr><td>Sigmoid (%)</td><td>3 (25.0)</td><td>4 (50.0)</td></tr></table>
<table><tr><td>Variable</td><td>Male (n=12)</td><td>Female (n=8)</td></tr><tr><td colspan="3">Age (years)</td></tr><tr><td>Mean</td><td>63.50</td><td>73.38</td></tr><tr><td>Range</td><td>21–80</td><td>63–87</td></tr><tr><td>Minimum (%)</td><td>21 (12.5)</td><td>63 (25.0)</td></tr><tr><td>Maximum (%)</td><td>80 (12.5)</td><td>87 (37.5)</td></tr><tr><td colspan="3">Grade of differentiation (n)</td></tr><tr><td>IIB (%)</td><td>1 (8.3)</td><td>0 (0)</td></tr><tr><td>IIC (%)</td><td>1 (8.3)</td><td>0 (0)</td></tr><tr><td>IIIB (%)</td><td>1 (8.3)</td><td>2 (25.0)</td></tr><tr><td>IIIA (%)</td><td>1 (8.3)</td><td>1 (12.5)</td></tr><tr><td>Colon (%)</td><td>9 (75.0)</td><td>4 (50.0)</td></tr></table>
<table><tr><td>Sigmoid (%)</td><td>3 (25.0)</td><td>4 (50.0)</td></tr></table>
938f7993bbde7c8310e572e9f6002502be2c06cd6b96b08391ef2286d5ad4c66.png
complex
<table><tr><td></td><td></td><td colspan="2">pI</td></tr><tr><td>Spot</td><td>Relative zymolytic level</td><td>Without phosphatase</td><td>After phosphatase treatment</td></tr><tr><td>1</td><td>18</td><td>5.005</td><td>5.129</td></tr><tr><td>2</td><td>13</td><td>5.048</td><td>5.175</td></tr><tr><td>3</td><td>52</td><td>5.110</td><td>5.228</td></tr><tr><td>4</td><td>13</td><td>5.169</td><td>5.276</td></tr><tr><td>5</td><td>5</td><td>5.226</td><td>5.330</td></tr></table>
<table><tr><td></td><td></td><td colspan="2">pI</td></tr><tr><td>Spot</td><td>Relative zymolytic level</td><td>Without phosphatase</td><td>After phosphatase treatment</td></tr><tr><td>1</td><td>18</td><td>5.005</td><td>5.129</td></tr><tr><td>2</td><td>13</td><td>5.048</td><td>5.175</td></tr><tr><td></td><td>5</td><td>5</td><td>5.22</td></tr></table>
<table><tr><td>3</td><td>2</td><td>.110</td><td>8</td></tr><tr><td>4</td><td>13</td><td>5.169</td><td>5.276</td></tr><tr><td>5</td><td>5</td><td>5.226</td><td>5.330</td></tr></table>
ca2e6da9176daa13a4e38760d5278cedc38743b4295e10cba31fe60c639ad223.png
complex
<table><tr><td>Cases</td><td>Sex/Age</td><td>Site</td><td>Depth</td><td>Largest diameter (cm)</td><td>Immunohistochemistry</td><td>Karyotype</td></tr><tr><td rowspan="4">1</td><td rowspan="4">M/59</td><td rowspan="4">Paratesticular</td><td rowspan="4">Subcutaneous</td><td rowspan="4">5.5</td><td>CD34 Positive</td><td rowspan="4">45,XY,add(5)(p13~15),-7,der(13)t(1;13)(q12~21;q14~21),-14,der(16)t(7;16)(q11;q22),del(18)(q21),+mar[9]/46,XY[2]</td></tr><tr><td>S100 Negative</td></tr><tr><td>ER Negative</td></tr><tr><td>PGR Negative</td></tr><tr><td rowspan="4">2</td><td rowspan="4">M/79</td><td rowspan="4">Scrotum</td><td rowspan="4">Subcutaneous</td><td rowspan="4">7</td><td>CD34 Positive</td><td rowspan="4">46,XY,t(10;15)(p13;q22),del(13)(q12q22)[15]</td></tr><tr><td>S100 Negative</td></tr><tr><td>ER Focal positive (20%)</td></tr><tr><td>PGR Focal positive (10%)</td></tr></table>
<table><tr><td>Cases</td><td>Sex/Age</td><td>Site</td><td>Depth</td><td>Largest diameter (cm)</td><td>Immunohistochemistry</td><td>Karyotype</td></tr><tr><td rowspan="4">1</td><td rowspan="4">M/59</td><td rowspan="4">Paratesticular</td><td rowspan="4">Subcutaneous</td><td rowspan="4">5.5</td><td>CD34 Positive</td><td rowspan="4">45,XY,add(5)(p13~15),-7,der(13)t(1;13)(q12~21;q14~21),-14,der(16)t(7;16)(q11;q22),del(18)(q21),+mar[9]/46,XY[2]</td></tr><tr><td>S100 Negative</td></tr><tr><td>ER Negative</td></tr><tr><td>PGR Negative</td></tr><tr><td rowspan="2">2</td><td rowspan="2">M/79</td><td rowspan="2">Scrotum</td><td rowspan="2">Subcutaneous</td><td rowspan="2">7</td><td>CD34 Positive</td><td rowspan="2">46,XY,t(10;15)(p13;q22),del(13)(q12q22)[15]</td></tr><tr><td>S100 Negative</td></tr></table>
<table><tr><td rowspan="2">2</td><td rowspan="2">M/79</td><td rowspan="2">Scrotum</td><td rowspan="2">Subcutaneous</td><td rowspan="2">7</td><td>ER Focal positive (20%)</td><td rowspan="2">46,XY,t(10;15)(p13;q22),del(13)(q12q22)[15]</td></tr><tr><td>PGR Focal positive (10%)</td></tr></table>
70a12ca4191e0df845ed49c7775ca158e3247700b31194dd4cb80e304603cc60.png
simple
<table><tr><td>HA concentration, %</td><td>HA/DVS weight ratio</td><td><i>&#958;</i> (nm)</td></tr><tr><td>5</td><td>10 : 1</td><td>223 &#177; 5</td></tr><tr><td>5</td><td>5 : 1</td><td>94 &#177; 6</td></tr></table>
<table><tr><td>HA concentration, %</td><td>HA/DVS weight ratio</td></tr><tr><td>5</td><td>10 : 1</td></tr><tr><td>5</td><td>5 : 1</td></tr></table>
<table><tr><td>ξ (nm)</td></tr><tr><td>223 ± 5</td></tr><tr><td>94 ± 6</td></tr></table>
b20cc97fcaed88c7af28bd457751bf4918ee982143000509e8b639267d48d1e1.png
complex
<table><tr><td></td><td colspan="2">Small ponds</td><td colspan="2">Large ponds</td></tr><tr><td>Taxonomic groups</td><td>Periphyton</td><td>Phytoplankton</td><td>Periphyton</td><td>Phytoplankton</td></tr><tr><td>Chlorophytes</td><td>p &gt; 0.05</td><td>p = 0.045</td><td>p = 0.013</td><td>p = 0.004</td></tr><tr><td>Euglenophytes</td><td>p &gt; 0.05</td><td>p &gt; 0.05</td><td>p = 0.021</td><td>p &gt; 0.05</td></tr><tr><td>Diatoms</td><td>p = 0.013</td><td>p &gt; 0.05</td><td>p &gt; 0.05</td><td>p &gt; 0.05</td></tr><tr><td>Dinophytes</td><td>p = 0.001</td><td>p = 0.038</td><td>p &gt; 0.05</td><td>p &gt; 0.05</td></tr><tr><td>Cyanoprocaryotes</td><td>p &gt; 0.05</td><td>p &gt; 0.05</td><td>p = 0.023</td><td>p = 0.020</td></tr></table>
<table><tr><td></td></tr><tr><td>Taxonomic groups</td></tr><tr><td>Chlorophytes</td></tr><tr><td>Euglenophytes</td></tr><tr><td>Diatoms</td></tr><tr><td>Dinophytes</td></tr><tr><td>Cyanoprocaryotes</td></tr></table>
<table><tr><td colspan="2">Small ponds</td><td colspan="2">Large ponds</td></tr><tr><td>Periphyton</td><td>Phytoplankton</td><td>Periphyton</td><td>Phytoplankton</td></tr><tr><td>p > 0.05</td><td>p = 0.045</td><td>p = 0.013</td><td>p = 0.004</td></tr><tr><td>p > 0.05</td><td>p > 0.05</td><td>p = 0.021</td><td>p > 0.05</td></tr><tr><td>p = 0.013</td><td>p > 0.05</td><td>p > 0.05</td><td>p > 0.05</td></tr><tr><td>p = 0.001</td><td>p = 0.038</td><td>p > 0.05</td><td>p > 0.05</td></tr><tr><td>p > 0.05</td><td>p > 0.05</td><td>p = 0.023</td><td>p = 0.020</td></tr></table>
c8f6bb3a3f22266814e86d209a821e75bab4128e0c62ed27af9dac680e11ad42.png
simple
<table><tr><td></td><td>Control</td><td>Concussion</td></tr><tr><td><i>n</i></td><td>7</td><td>10</td></tr><tr><td>Age (year)</td><td>20.0 &#177; 1.4</td><td>19.4 &#177; 1.1</td></tr><tr><td>Height (m)</td><td>1.80 &#177; 0.11</td><td>1.79 &#177; 0.11</td></tr><tr><td>Weight (m)</td><td>81.2 &#177; 13.8</td><td>78.4 &#177; 12.2</td></tr><tr><td>BMI (kg/m<sup>2</sup>)</td><td>24.8 &#177; 1.7</td><td>24.7 &#177; 4.0</td></tr><tr><td>Gender (M/F)</td><td>6/1</td><td>8/2</td></tr></table>
<table><tr><td></td><td>Control</td><td>Concussion</td></tr><tr><td>n</td><td>7</td><td>10</td></tr><tr><td>Age (year)</td><td>20.0 ± 1.4</td><td>19.4 ± 1.1</td></tr><tr><td>Height (m)</td><td>1.80 ± 0.11</td><td>1.79 ± 0.11</td></tr><tr><td>Weight (m)</td><td>81.2 ± 13.8</td><td>78.4 ± 12.2</td></tr><tr><td>BMI (kg/m2)</td><td>24.8 ± 1.7</td><td>24.7 ± 4.0</td></tr></table>
<table><tr><td>Gender (M/F)</td><td>6/1</td><td>8/2</td></tr></table>
14b04101429c69b596625808ecb08f98bee6f8cc1bde92cacbcb0d8facad7867.png
simple
<table><tr><td></td><td>Pairs</td><td>Trios</td></tr><tr><td>HGDP reference</td><td>0.0009</td><td>0.0026</td></tr><tr><td>Reich2012 reference</td><td>0.0013</td><td>0.0034</td></tr></table>
<table><tr><td></td><td>Pairs</td><td>Trios</td></tr><tr><td>HGDP reference</td><td>0.0009</td><td>0.0026</td></tr></table>
<table><tr><td></td><td>Pairs</td><td>Trios</td></tr><tr><td>Reich2012 reference</td><td>0.0013</td><td>0.0034</td></tr></table>
9af85fd3551fd3351c12fbe73f59699638065fb6a265e24ce6dc23b1aff3a8d6.png
simple
<table><tr><td>Measurement</td><td>Single measure ICC (2,1)</td><td>95% CI</td><td>SEM cm (mm)</td></tr><tr><td>Right shoulder (1<sup>st </sup>measurement)</td><td>.92</td><td>.86 to .96</td><td>0.40 (4 mm)</td></tr><tr><td>Left shoulder (1<sup>st </sup>measurement)</td><td>.93</td><td>.88 to .96</td><td>0.37 (4 mm)</td></tr><tr><td>Dominant shoulder (1<sup>st </sup>measurement)</td><td>.93</td><td>.86 to .96</td><td>0.38 (4 mm)</td></tr><tr><td>Non dominant shoulder (1<sup>st </sup>measurement)</td><td>.92</td><td>.87 to .96</td><td>0.39 (4 mm)</td></tr><tr><td></td><td>Average measure ICC (2,3)</td><td>95% CI</td><td>SEM cm (mm)</td></tr><tr><td>Right shoulder (mean of 3)</td><td>.96</td><td>.93 to .98</td><td>0.29 (3 mm)</td></tr><tr><td>Left shoulder (mean of 3)</td><td>.92</td><td>.94 to .98</td><td>0.28 (3 mm)</td></tr><tr><td>Dominant shoulder (mean of 3)</td><td>.96</td><td>.94 to .98</td><td>0.29 (3 mm)</td></tr><tr><td>Non dominant shoulder (mean of 3)</td><td>.96</td><td>.93 to .98</td><td>0.28 (3 mm)</td></tr></table>
<table><tr><td>Measurement</td><td>Single measure ICC (2,1)</td><td>95% CI</td><td>SEM cm (mm)</td></tr><tr><td>Right shoulder (1st measurement)</td><td>.92</td><td>.86 to .96</td><td>0.40 (4 mm)</td></tr><tr><td>Left shoulder (1st measurement)</td><td>.93</td><td>.88 to .96</td><td>0.37 (4 mm)</td></tr><tr><td>Dominant shoulder (1st measurement)</td><td>.93</td><td>.86 to .96</td><td>0.38 (4 mm)</td></tr></table>
<table><tr><td>Non dominant shoulder (1st measurement)</td><td>.92</td><td>.87 to .96</td><td>0.39 (4 mm)</td></tr><tr><td></td><td>Average measure ICC (2,3)</td><td>95% CI</td><td>SEM cm (mm)</td></tr><tr><td>Right shoulder (mean of 3)</td><td>.96</td><td>.93 to .98</td><td>0.29 (3 mm)</td></tr><tr><td>Left shoulder (mean of 3)</td><td>.92</td><td>.94 to .98</td><td>0.28 (3 mm)</td></tr><tr><td>Dominant shoulder (mean of 3)</td><td>.96</td><td>.94 to .98</td><td>0.29 (3 mm)</td></tr><tr><td>Non dominant shoulder (mean of 3)</td><td>.96</td><td>.93 to .98</td><td>0.28 (3 mm)</td></tr></table>
0a2fa06538fb0549c52abebb0e4c561cf6b0141d69fb3745f166079eb4906dde.png
complex
<table><tr><td rowspan="2">variables</td><td rowspan="2">Category</td><td colspan="2">Latrine utilization</td><td rowspan="2">COR (95% CI)</td><td rowspan="2">AOR (95% CI)</td></tr><tr><td>Yes (%)</td><td>No (%)</td></tr><tr><td rowspan="3">Age</td><td>&lt; 35</td><td>45 (51.7)</td><td>41 (48.3)</td><td>2.820 (1.435, 5.539)</td><td><i>3.112 (1.539, 6.294)</i>**</td></tr><tr><td>36&#8211;50</td><td>80 (50.6)</td><td>78 (49.4)</td><td>2.699 (1.462, 4.984)</td><td><i>2.776 (1.464, 5.266)</i>**</td></tr><tr><td>&gt; 50</td><td>19 (27.5)</td><td>50 (72.5)</td><td>1.00</td><td>1.00</td></tr><tr><td rowspan="2">Education</td><td>Illiterate</td><td>77 (41.0)</td><td>110 (59.0)</td><td>1.00</td><td><i>1.00</i></td></tr><tr><td>Primary and above</td><td>67 (46.8)</td><td>59 (53.2)</td><td>1.637 (1.039, 2.58)</td><td>2.03 (1.427, 4.638)</td></tr><tr><td rowspan="2">Occupation</td><td>Other</td><td>20 (69.0)</td><td>8 (31.0)</td><td>1.00</td><td>1.00</td></tr><tr><td>Farmer</td><td>124 (43.5)</td><td>161 (56.5)</td><td>0.347 (0.153, 0.788)</td><td><i>0.351 (0.150, 0.826)</i>*</td></tr><tr><td rowspan="4">Type of latrine</td><td>Open pit</td><td>8 (23.5)</td><td>25 (76.5)</td><td>1.00</td><td></td></tr><tr><td>Pit without slab</td><td>99 (45.2)</td><td>120 (54.8)</td><td>2.681 (1.162, 6.185)</td><td></td></tr><tr><td>Pit with slab</td><td>35 (60.3)</td><td>23 (39.7)</td><td>4.946 (1.910, 12.803)</td><td></td></tr><tr><td>Ventilated latrine</td><td>2 (66.7)</td><td>1 (33.3)</td><td>6.500 (0.519, 81.424)</td><td></td></tr><tr><td rowspan="2">Maintenance requirement</td><td>Need maintenance</td><td>118 (43.2)</td><td>154 (56.8)</td><td>1.00</td><td></td></tr><tr><td>Maintained</td><td>26 (63.4)</td><td>15 (36.6)</td><td>2.277 (1.155, 4.490)</td><td></td></tr><tr><td rowspan="3">Privacy</td><td>No privacy</td><td>89 (42.0)</td><td>122 (58.0)</td><td>1.00</td><td><i>1.00</i></td></tr><tr><td>Poor privacy</td><td>25 (39.7)</td><td>38 (60.3)</td><td>0.909 (0.512, 1.614)</td><td>0.822 (0.448, 1.508)</td></tr><tr><td>Adequate privacy</td><td>30 (76.9)</td><td>9 (23.1)</td><td>4.607 (2.084, 10.184)</td><td><i>2.942 (1.251, 6.919)</i>*</td></tr><tr><td rowspan="2">Latrine cleanness</td><td>No</td><td>101 (39.6)</td><td>153 (60.4)</td><td>1.00</td><td><i>1.00</i></td></tr><tr><td>Yes</td><td>43 (72.9)</td><td>16 (27.1)</td><td>4.098 (2.190, 7.667)</td><td><i>4.098 (2.190, 7.667)</i>***</td></tr></table>
<table><tr><td rowspan="2">variables</td><td rowspan="2">Category</td><td colspan="2">Latrine utilization</td><td rowspan="2">COR (95% CI)</td></tr><tr><td>Yes (%)</td><td>No (%)</td></tr><tr><td rowspan="3">Age</td><td>< 35</td><td>45 (51.7)</td><td>41 (48.3)</td><td>2.820 (1.435, 5.539)</td></tr><tr><td>36–50</td><td>80 (50.6)</td><td>78 (49.4)</td><td>2.699 (1.462, 4.984)</td></tr><tr><td>> 50</td><td>19 (27.5)</td><td>50 (72.5)</td><td>1.00</td></tr><tr><td rowspan="2">Education</td><td>Illiterate</td><td>77 (41.0)</td><td>110 (59.0)</td><td>1.00</td></tr><tr><td>Primary and above</td><td>67 (46.8)</td><td>59 (53.2)</td><td>1.637 (1.039, 2.58)</td></tr><tr><td rowspan="2">Occupation</td><td>Other</td><td>20 (69.0)</td><td>8 (31.0)</td><td>1.00</td></tr><tr><td>Farmer</td><td>124 (43.5)</td><td>161 (56.5)</td><td>0.347 (0.153, 0.788)</td></tr><tr><td rowspan="4">Type of latrine</td><td>Open pit</td><td>8 (23.5)</td><td>25 (76.5)</td><td>1.00</td></tr><tr><td>Pit without slab</td><td>99 (45.2)</td><td>120 (54.8)</td><td>2.681 (1.162, 6.185)</td></tr><tr><td>Pit with slab</td><td>35 (60.3)</td><td>23 (39.7)</td><td>4.946 (1.910, 12.803)</td></tr><tr><td>Ventilated latrine</td><td>2 (66.7)</td><td>1 (33.3)</td><td>6.500 (0.519, 81.424)</td></tr><tr><td rowspan="2">Maintenance requirement</td><td>Need maintenance</td><td>118 (43.2)</td><td>154 (56.8)</td><td>1.00</td></tr><tr><td>Maintained</td><td>26 (63.4)</td><td>15 (36.6)</td><td>2.277 (1.155, 4.490)</td></tr><tr><td rowspan="3">Privacy</td><td>No privacy</td><td>89 (42.0)</td><td>122 (58.0)</td><td>1.00</td></tr><tr><td>Poor privacy</td><td>25 (39.7)</td><td>38 (60.3)</td><td>0.909 (0.512, 1.614)</td></tr><tr><td>Adequate privacy</td><td>30 (76.9)</td><td>9 (23.1)</td><td>4.607 (2.084, 10.184)</td></tr><tr><td rowspan="2">Latrine cleanness</td><td>No</td><td>101 (39.6)</td><td>153 (60.4)</td><td>1.00</td></tr><tr><td>Yes</td><td>43 (72.9)</td><td>16 (27.1)</td><td>4.098 (2.190, 7.667)</td></tr></table>
<table><tr><td rowspan="2">AOR (95% CI)</td></tr><tr></tr><tr><td>3.112 (1.539, 6.294)**</td></tr><tr><td>2.776 (1.464, 5.266)**</td></tr><tr><td>1.00</td></tr><tr><td>1.00</td></tr><tr><td>2.03 (1.427, 4.638)</td></tr><tr><td>1.00</td></tr><tr><td>0.351 (0.150, 0.826)*</td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td></td></tr><tr><td>1.00</td></tr><tr><td>0.822 (0.448, 1.508)</td></tr><tr><td>2.942 (1.251, 6.919)*</td></tr><tr><td>1.00</td></tr><tr><td>4.098 (2.190, 7.667)***</td></tr></table>
6ec097666ce8c93015fd40839044bd25a0c228ae64263dfee8024780d4c1aee7.png
complex
<table><tr><td rowspan="2">Clinical signs and symptoms (%)</td><td colspan="2">Percentage positivity (%)</td></tr><tr><td>DF (<i>n</i> = 145)</td><td>DHF (<i>n</i> = 74)</td></tr><tr><td>Headache</td><td>89.5</td><td>95.4</td></tr><tr><td>Retroorbital pain</td><td>58.3</td><td>69.3</td></tr><tr><td>Nausea/vomiting</td><td>72.7</td><td>75.5</td></tr><tr><td>Rash</td><td>6.6</td><td>13.1</td></tr><tr><td>Abdominal pain<sup>&#8727;</sup></td><td>29.3</td><td>48.0</td></tr><tr><td>Sore throat</td><td>18.2</td><td>28.5</td></tr><tr><td>Lethargy</td><td>82.5</td><td>89.4</td></tr><tr><td>Myalgia</td><td>84.6</td><td>91.8</td></tr><tr><td>Arthralgia</td><td>85</td><td>88.1</td></tr><tr><td>Red eyes</td><td>25.8</td><td>20.9</td></tr><tr><td>Ecchymosis/bruising</td><td>2.3</td><td>1.6</td></tr><tr><td>Bleeding</td><td>8.7</td><td>15.9</td></tr></table>
<table><tr><td rowspan="2">Clinical signs and symptoms (%)</td><td colspan="2">Percentage positivity (%)</td></tr><tr><td>DF (n = 145)</td><td>DHF (n = 74)</td></tr><tr><td>Headache</td><td>89.5</td><td>95.4</td></tr><tr><td>Retroorbital pain</td><td>58.3</td><td>69.3</td></tr><tr><td>Nausea/vomiting</td><td>72.7</td><td>75.5</td></tr></table>
<table><tr><td rowspan="2">Clinical signs and symptoms (%)</td><td colspan="2">Percentage positivity (%)</td></tr><tr><td>DF (n = 145)</td><td>DHF (n = 74)</td></tr><tr><td>Rash</td><td>6.6</td><td>13.1</td></tr><tr><td>Abdominal pain∗</td><td>29.3</td><td>48.0</td></tr><tr><td>Sore throat</td><td>18.2</td><td>28.5</td></tr><tr><td>Lethargy</td><td>82.5</td><td>89.4</td></tr><tr><td>Myalgia</td><td>84.6</td><td>91.8</td></tr><tr><td>Arthralgia</td><td>85</td><td>88.1</td></tr><tr><td>Red eyes</td><td>25.8</td><td>20.9</td></tr><tr><td>Ecchymosis/bruising</td><td>2.3</td><td>1.6</td></tr><tr><td>Bleeding</td><td>8.7</td><td>15.9</td></tr></table>
18a738debe11708b2c655df8041ec69e11312990812c909bbbd0e773f4c488b9.png
simple
<table><tr><td></td><td><i>&#949;</i>-recommended</td><td><i>&#949;</i>-optimized</td><td>C-recommended</td><td>C-optimized</td><td><i>&#947;</i>-optimized</td></tr><tr><td>Model for H2-Db</td><td>0.0475</td><td>0.0150</td><td>10.34</td><td>18.39</td><td>0.0316</td></tr><tr><td>Model for H2-Kb</td><td>0.0513</td><td>0.5134</td><td>10.88</td><td>34.41</td><td>0.0316</td></tr><tr><td>Model for H2-Kk</td><td>0.0152</td><td>0.0152</td><td>10.00</td><td>10.00</td><td>0.3162</td></tr></table>
<table><tr><td></td><td>ε-recommended</td><td>ε-optimized</td><td>C-recommended</td><td>C-optimized</td><td>γ-optimized</td></tr><tr><td>Model for H2-Db</td><td>0.0475</td><td>0.0150</td><td>10.34</td><td>18.39</td><td>0.0316</td></tr></table>
<table><tr><td></td><td>ε-recommended</td><td>ε-optimized</td><td>C-recommended</td><td>C-optimized</td><td>γ-optimized</td></tr><tr><td>Model for H2-Kb</td><td>0.0513</td><td>0.5134</td><td>10.88</td><td>34.41</td><td>0.0316</td></tr><tr><td>Model for H2-Kk</td><td>0.0152</td><td>0.0152</td><td>10.00</td><td>10.00</td><td>0.3162</td></tr></table>
0d72886e61f6b523b63c5ec0cbb5e965e6419998934bd1626b020a450a4ad094.png
simple
<table><tr><td>Cell line</td><td>STL/cell</td><td>Significance</td></tr><tr><td>AG11395 EV1</td><td>11.4</td><td></td></tr><tr><td>AG11395 EV2</td><td>9.2</td><td></td></tr><tr><td>AG11395 EV3</td><td>10.6</td><td></td></tr><tr><td>AG11395 WRN1</td><td>7.1</td><td><i>P</i> &lt; 0.0005</td></tr><tr><td>AG11395 WRN2</td><td>6.9</td><td><i>P</i> &lt; 0.01</td></tr><tr><td>AG11395 WRN3</td><td>4.4</td><td><i>P</i> &lt; 0.0001</td></tr><tr><td>AG11395 hTERT</td><td>2.8</td><td><i>P</i> &lt; 0.00001</td></tr></table>
<table><tr><td>Cell line</td><td>STL/cell</td><td>Significance</td></tr></table>
<table><tr><td>AG11395 EV1</td><td>11.4</td><td></td></tr><tr><td>AG11395 EV2</td><td>9.2</td><td></td></tr><tr><td>AG11395 EV3</td><td>10.6</td><td></td></tr><tr><td>AG11395 WRN1</td><td>7.1</td><td>P < 0.0005</td></tr><tr><td>AG11395 WRN2</td><td>6.9</td><td>P < 0.01</td></tr><tr><td>AG11395 WRN3</td><td>4.4</td><td>P < 0.0001</td></tr><tr><td>AG11395 hTERT</td><td>2.8</td><td>P < 0.00001</td></tr></table>
ce421c13e261d6ab9ecbdd180dcd5d873cbe97d28d81f05fcbb52e4589449b0e.png
complex
<table><tr><td></td><td></td><td></td><td colspan="2">Diagnostic group</td><td colspan="4">Comparison</td></tr><tr><td></td><td></td><td></td><td>22q11.2DS</td><td>Controls</td><td><i>t</i> test</td><td>Pearson&#8217;s chi-square</td><td>ANOVA</td><td><i>p</i> value</td></tr><tr><td><i>N</i></td><td></td><td></td><td>95</td><td>100</td><td></td><td></td><td></td><td></td></tr><tr><td>Gender (male (%))</td><td></td><td></td><td>45 (47.36 %)</td><td>48 (48 %)</td><td></td><td>0.008</td><td></td><td>0.930</td></tr><tr><td>Age at first time point (mean (SD))</td><td></td><td></td><td>12.80 (4.23)</td><td>13.17 (4.43)</td><td>0.596</td><td></td><td></td><td>0.552</td></tr><tr><td>Full-scale IQ at first time point (mean (SD))</td><td></td><td></td><td>70.71 (12.27)</td><td>110.37 (13.62)</td><td></td><td></td><td>454.57</td><td>&lt;0.001</td></tr><tr><td>VABS outcome measure at last time point (mean (SD))</td><td></td><td>ABC score</td><td>66.73 (12.53)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Communication score</td><td>71.17 (17.00)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Daily living skills score</td><td>71.06 (15.22)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Socialization score</td><td>73.83 (14.51)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Psychiatric diagnosis (<i>N</i> (%))</td><td></td><td>Simple phobia</td><td>42 (44.21 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Attention deficit disorder</td><td>36 (37.89 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Generalized anxiety</td><td>16 (16.84 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Major depressive episode</td><td>13 (13.68 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Psychosis</td><td>8 (8.42 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Obsessive-compulsive disorder</td><td>7 (7.37 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Psychotropic medication</td><td>Total</td><td></td><td>39 (41.05 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Categories</td><td>Methylphenidate</td><td>26 (66.66 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Antidepressants</td><td>12 (30.77 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Antipsychotics</td><td>7 (17.95 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Antiepileptic</td><td>7 (17.95 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Anxiolytic</td><td>3 (7.69 %)</td><td></td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td></td><td></td><td></td><td colspan="2">Diagnostic group</td><td colspan="4">Comparison</td></tr><tr><td></td><td></td><td></td><td>22q11.2DS</td><td>Controls</td><td>t test</td><td>Pearson’s chi-square</td><td>ANOVA</td><td>p value</td></tr><tr><td>N</td><td></td><td></td><td>95</td><td>100</td><td></td><td></td><td></td><td></td></tr><tr><td>Gender (male (%))</td><td></td><td></td><td>45 (47.36 %)</td><td>48 (48 %)</td><td></td><td>0.008</td><td></td><td>0.930</td></tr><tr><td>Age at first time point (mean (SD))</td><td></td><td></td><td>12.80 (4.23)</td><td>13.17 (4.43)</td><td>0.596</td><td></td><td></td><td>0.552</td></tr><tr><td>Full-scale IQ at first time point (mean (SD))</td><td></td><td></td><td>70.71 (12.27)</td><td>110.37 (13.62)</td><td></td><td></td><td>454.57</td><td><0.001</td></tr><tr><td>VABS outcome measure at last time point (mean (SD))</td><td></td><td>ABC score</td><td>66.73 (12.53)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Communication score</td><td>71.17 (17.00)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Daily living skills score</td><td>71.06 (15.22)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Socialization score</td><td>73.83 (14.51)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Psychiatric diagnosis (N (%))</td><td></td><td>Simple phobia</td><td>42 (44.21 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Attention deficit disorder</td><td>36 (37.89 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Generalized anxiety</td><td>16 (16.84 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Major depressive episode</td><td>13 (13.68 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Psychosis</td><td>8 (8.42 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>Obsessive-compulsive disorder</td><td>7 (7.37 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Psychotropic medication</td><td>Total</td><td></td><td>39 (41.05 %)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Categories</td><td>Methylphenidate</td><td>26 (66.66 %)</td><td></td><td></td><td></td><td></td><td></td></tr></table>
<table><tr><td>Antidepressants</td><td>12 (30.77 %)</td></tr><tr><td>Antipsychotics</td><td>7 (17.95 %)</td></tr><tr><td>Antiepileptic</td><td>7 (17.95 %)</td></tr><tr><td>Anxiolytic</td><td>3 (7.69 %)</td></tr></table>
d2546fe9eff813fd5fe49b9c8d242c744e741ad587484c01729a952e110b017e.png
complex
<table><tr><td rowspan="2">Virus</td><td>gorillas</td><td>orangutans</td><td>chimpanzees</td></tr><tr><td>n = 77</td><td>n = 179</td><td>n = 305</td></tr><tr><td>RSV</td><td>79.3 <sup>#</sup> (61)</td><td>72.1 (129)</td><td>96.4 (294)</td></tr><tr><td>hMPV</td><td>46.8 (36)</td><td>10.1 (18)</td><td>42.6 (130)</td></tr><tr><td>inf A H3N2</td><td>3.9 (3)</td><td>5.6 (10)</td><td>11.2 (34)</td></tr><tr><td>inf A H1N1</td><td>3.9 (3)</td><td>19.0 (34)</td><td>71.5 (218)</td></tr><tr><td>infl B</td><td>58.4 (45)</td><td>75.4 (135)</td><td>26.2 (80)</td></tr></table>
<table><tr><td rowspan="2">Virus</td><td>gorillas</td><td>orangutans</td><td>chimpanzees</td></tr><tr><td>n = 77</td><td>n = 179</td><td>n = 305</td></tr><tr><td>RSV</td><td>79.3 # (61)</td><td>72.1 (129)</td><td>96.4 (294)</td></tr></table>
<table><tr><td rowspan="2">Virus</td><td>gorillas</td><td>orangutans</td><td>chimpanzees</td></tr><tr><td>n = 77</td><td>n = 179</td><td>n = 305</td></tr><tr><td>hMPV</td><td>46.8 (36)</td><td>10.1 (18)</td><td>42.6 (130)</td></tr><tr><td>inf A H3N2</td><td>3.9 (3)</td><td>5.6 (10)</td><td>11.2 (34)</td></tr><tr><td>inf A H1N1</td><td>3.9 (3)</td><td>19.0 (34)</td><td>71.5 (218)</td></tr><tr><td>infl B</td><td>58.4 (45)</td><td>75.4 (135)</td><td>26.2 (80)</td></tr></table>
aa7528cc6fe46da604eab4284c1fad500c09dec15ef57d07275f962ad6d37fe2.png
complex
<table><tr><td>Variable</td><td>RMP</td><td>CI 95%</td><td><i>P</i></td></tr><tr><td colspan="4">Gender</td></tr><tr><td> Male</td><td>1</td><td></td><td></td></tr><tr><td> Female</td><td>23.6</td><td>6.9&#8211;81.1</td><td>&lt;0.05</td></tr><tr><td colspan="4">Occupacion</td></tr><tr><td> Other</td><td>1</td><td></td><td></td></tr><tr><td> Housewife</td><td>22.8</td><td>4.9&#8211;106.1</td><td>&lt;0.05</td></tr><tr><td colspan="4">Contact with Stagnant Water</td></tr><tr><td> No</td><td>1</td><td></td><td></td></tr><tr><td> Yes</td><td>5.2</td><td>1.7&#8211;15.9</td><td>&lt;0.05</td></tr><tr><td colspan="4">Contact with Urine or Excrement</td></tr><tr><td> No</td><td>1</td><td></td><td></td></tr><tr><td> Yes</td><td>5.1</td><td>1.9&#8211;13.1</td><td>&lt;0.05</td></tr></table>
<table><tr><td>Variable</td><td>RMP</td><td>CI 95%</td><td>P</td></tr><tr><td colspan="4">Gender</td></tr><tr><td>Male</td><td>1</td><td></td><td></td></tr><tr><td>Female</td><td>23.6</td><td>6.9–81.1</td><td><0.05</td></tr><tr><td colspan="4">Occupacion</td></tr><tr><td>Other</td><td>1</td><td></td><td></td></tr><tr><td>Housewife</td><td>22.8</td><td>4.9–106.1</td><td><0.05</td></tr><tr><td colspan="4">Contact with Stagnant Water</td></tr><tr><td>No</td><td>1</td><td></td><td></td></tr><tr><td>Yes</td><td>5.2</td><td>1.7–15.9</td><td><0.05</td></tr></table>
<table><tr><td colspan="4">Contact with Urine or Excrement</td></tr><tr><td>No</td><td>1</td><td></td><td></td></tr><tr><td>Yes</td><td>5.1</td><td>1.9–13.1</td><td><0.05</td></tr></table>
a84887f1cdba09eb02ff526908fcb10f54e2cda2b1c4b9db833249d7067ed4ba.png
complex
<table><tr><td>Variables</td><td></td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted</td></tr><tr><td></td><td>N</td><td>OR (95% CI)</td><td>P value</td><td>OR (95% CI)</td><td>P value</td></tr><tr><td>Age group (months)</td><td></td><td>1.0 (0.9;1.050)</td><td>0.6</td><td></td><td></td></tr><tr><td>06-11</td><td>144</td><td>1</td><td></td><td>1</td><td>0.4</td></tr><tr><td>12-23</td><td>273</td><td>0.6 (0.3;1.2)</td><td>0.1</td><td>0.7 (0.3;1.2)</td><td>0.2</td></tr><tr><td>24-35</td><td>284</td><td>0.7 (0.3;1.6)</td><td>0.3</td><td>0.7 (0.3;1.7)</td><td>0.5</td></tr><tr><td>36-47</td><td>301</td><td>0.9 (0.4;1.9)</td><td>0.7</td><td>1.0 (0.5;2.2)</td><td>0.9</td></tr><tr><td>48-59</td><td>246</td><td>0.6 (0.2;1.3)</td><td>0.1</td><td>0.6 (0.2;1.4)</td><td>0.2</td></tr><tr><td>Health regions</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Western Region</td><td>56</td><td>1</td><td></td><td>1</td><td>0.1</td></tr><tr><td>North Bank West Region</td><td>104</td><td>0.8 (0.2;4.1)</td><td>0.8</td><td>0.5 (0.1;2.4)</td><td>0.4</td></tr><tr><td>Central River Region</td><td>714</td><td>1.5 (0.6;4.0)</td><td>0.4</td><td>0.6 (0.3;1.4)</td><td>0.3</td></tr><tr><td>Upper River Region</td><td>359</td><td>0.6 (0.2;1.9)</td><td>0.3</td><td>0.4 (0.1;1.0)</td><td>0.06</td></tr><tr><td>Sex</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>681</td><td>1</td><td></td><td>1</td><td>0.6</td></tr><tr><td>Female</td><td>567</td><td>0.9 (0.6;1.4)</td><td>0.8</td><td>0.9 (0.6;1.3)</td><td></td></tr><tr><td>Wealth quintiles</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Poorest</td><td>500</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Second</td><td>224</td><td>0.4 (0.2;0.8)</td><td>0.009</td><td>0.4 (0.2;0.7)</td><td>0.002</td></tr><tr><td>Third</td><td>260</td><td>0.5 (0.2;0.9)</td><td>0.03</td><td>0.5 (0.3;0.9)</td><td>0.03</td></tr><tr><td>Fourth</td><td>146</td><td>0.2 (0.1;0.5)</td><td>0.001</td><td>0.3 (0.1;0.6)</td><td>0.002</td></tr><tr><td>Richest</td><td>103</td><td>0.1 (0.04;0.3)</td><td>&lt;0.001</td><td>0.1 (0.04;0.3)</td><td>&lt;0.001</td></tr><tr><td>Wall type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>451</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>797</td><td>2.3 (1.3;4.1)</td><td>0.005</td><td>1.8 (1.1;3.1)</td><td>0.01</td></tr><tr><td>Floor type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>644</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>604</td><td>2.5 (1.5;3.9)</td><td>&lt;0.001</td><td>2.0 (1.4;3.0)</td><td>0.001</td></tr><tr><td>Roof type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>799</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>449</td><td>2.4 (1.6;3.7)</td><td>&lt;0.001</td><td>2.2 (1.4;3.3)</td><td>&lt;0.001</td></tr><tr><td>Window type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>730</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>513</td><td>2.0 (1.3;3.0)</td><td>0.001</td><td>1.8 (1.1;3.0)</td><td>0.01</td></tr></table>
<table><tr><td>Variables</td><td></td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted</td></tr><tr><td></td><td>N</td><td>OR (95% CI)</td><td>P value</td><td>OR (95% CI)</td><td>P value</td></tr><tr><td>Age group (months)</td><td></td><td>1.0 (0.9;1.050)</td><td>0.6</td><td></td><td></td></tr><tr><td>06-11</td><td>144</td><td>1</td><td></td><td>1</td><td>0.4</td></tr><tr><td>12-23</td><td>273</td><td>0.6 (0.3;1.2)</td><td>0.1</td><td>0.7 (0.3;1.2)</td><td>0.2</td></tr></table>
<table><tr><td>24-35</td><td>284</td><td>0.7 (0.3;1.6)</td><td>0.3</td><td>0.7 (0.3;1.7)</td><td>0.5</td></tr><tr><td>36-47</td><td>301</td><td>0.9 (0.4;1.9)</td><td>0.7</td><td>1.0 (0.5;2.2)</td><td>0.9</td></tr><tr><td>48-59</td><td>246</td><td>0.6 (0.2;1.3)</td><td>0.1</td><td>0.6 (0.2;1.4)</td><td>0.2</td></tr><tr><td>Health regions</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Western Region</td><td>56</td><td>1</td><td></td><td>1</td><td>0.1</td></tr><tr><td>North Bank West Region</td><td>104</td><td>0.8 (0.2;4.1)</td><td>0.8</td><td>0.5 (0.1;2.4)</td><td>0.4</td></tr><tr><td>Central River Region</td><td>714</td><td>1.5 (0.6;4.0)</td><td>0.4</td><td>0.6 (0.3;1.4)</td><td>0.3</td></tr><tr><td>Upper River Region</td><td>359</td><td>0.6 (0.2;1.9)</td><td>0.3</td><td>0.4 (0.1;1.0)</td><td>0.06</td></tr><tr><td>Sex</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>681</td><td>1</td><td></td><td>1</td><td>0.6</td></tr><tr><td>Female</td><td>567</td><td>0.9 (0.6;1.4)</td><td>0.8</td><td>0.9 (0.6;1.3)</td><td></td></tr><tr><td>Wealth quintiles</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Poorest</td><td>500</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Second</td><td>224</td><td>0.4 (0.2;0.8)</td><td>0.009</td><td>0.4 (0.2;0.7)</td><td>0.002</td></tr><tr><td>Third</td><td>260</td><td>0.5 (0.2;0.9)</td><td>0.03</td><td>0.5 (0.3;0.9)</td><td>0.03</td></tr><tr><td>Fourth</td><td>146</td><td>0.2 (0.1;0.5)</td><td>0.001</td><td>0.3 (0.1;0.6)</td><td>0.002</td></tr><tr><td>Richest</td><td>103</td><td>0.1 (0.04;0.3)</td><td><0.001</td><td>0.1 (0.04;0.3)</td><td><0.001</td></tr><tr><td>Wall type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>451</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>797</td><td>2.3 (1.3;4.1)</td><td>0.005</td><td>1.8 (1.1;3.1)</td><td>0.01</td></tr><tr><td>Floor type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>644</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>604</td><td>2.5 (1.5;3.9)</td><td><0.001</td><td>2.0 (1.4;3.0)</td><td>0.001</td></tr><tr><td>Roof type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>799</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>449</td><td>2.4 (1.6;3.7)</td><td><0.001</td><td>2.2 (1.4;3.3)</td><td><0.001</td></tr><tr><td>Window type</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Good</td><td>730</td><td>1</td><td></td><td>1</td><td></td></tr><tr><td>Poor</td><td>513</td><td>2.0 (1.3;3.0)</td><td>0.001</td><td>1.8 (1.1;3.0)</td><td>0.01</td></tr></table>
38327e437c4d94e405d5a9630d569a41f887393ccccbd7832d48c5e562f6227c.png
simple
<table><tr><td></td><td>1ARU</td><td>1BGP</td><td>1H58</td></tr><tr><td>1CXP</td><td>9%</td><td>7%</td><td>6%</td></tr><tr><td>1ARU</td><td>-</td><td>14%</td><td>7%</td></tr><tr><td>1BGP</td><td>-</td><td>-</td><td>40%</td></tr></table>
<table><tr><td></td><td>1ARU</td><td>1BGP</td><td>1H58</td></tr></table>
<table><tr><td>1CXP</td><td>9%</td><td>7%</td><td>6%</td></tr><tr><td>1ARU</td><td>-</td><td>14%</td><td>7%</td></tr><tr><td>1BGP</td><td>-</td><td>-</td><td>40%</td></tr></table>
f197b3e3408c18ce57da7585205986ce4c9c10052609730f4b08150ac17e7f8e.png
complex
<table><tr><td>Theme</td><td>Sub-theme</td></tr><tr><td>1. Views on smoking</td><td>1.1 Hostility towards smoking</td></tr><tr><td rowspan="4">3. Reasons to quit smoking</td><td>3.1 To improve health</td></tr><tr><td>3.2 Social stigma</td></tr><tr><td>3.3 Saving money</td></tr><tr><td>3.4 Personal</td></tr><tr><td>4. Emotions connected with smoking initiation</td><td>4.1 Regret starting</td></tr><tr><td rowspan="3">6. Beliefs that influence quit attempts</td><td>6.1 Control of nicotine dependence</td></tr><tr><td>6.2 Motivation and willpower</td></tr><tr><td>6.3 Confidence</td></tr><tr><td>7. Difficulties quitting/cutting down</td><td>7.4 Lack of motivation</td></tr><tr><td>8. Goals</td><td>8.1 Smoking cessation</td></tr><tr><td rowspan="2">9. Methods used to quit smoking</td><td>9.1 Abrupt</td></tr><tr><td>9.2 Cut down first</td></tr><tr><td rowspan="3">10. Methods of cutting down</td><td>10.1 Not smoking as many cigarettes</td></tr><tr><td>10.2 Not smoking in the morning</td></tr><tr><td>10.3 Smoking only part of the cigarette</td></tr><tr><td rowspan="3">11. Non-medical aids to quit smoking</td><td>11.1 Distraction</td></tr><tr><td>11.2 Motivation</td></tr><tr><td>11.3 Exercising</td></tr><tr><td rowspan="3">12. Reasons for using NRT</td><td>12.1 To aid quit attempt</td></tr><tr><td>12.4 To help with cravings</td></tr><tr><td>12.5 Rid of habit</td></tr><tr><td rowspan="2">15. Factors to encourage use of NRT</td><td>15.1 Free samples</td></tr><tr><td>15.2 Aid quit attempt</td></tr><tr><td>16. Use of NRT</td><td>16.2 Incorrect use/underuse</td></tr><tr><td rowspan="2">17. Length of NRT use</td><td>17.1 Short-term</td></tr><tr><td>17.2 Long-term</td></tr><tr><td>18. Knowledge about NRT</td><td>18.1 Current regulations</td></tr><tr><td rowspan="5">19. Concerns about NRT</td><td>19.1 Addiction</td></tr><tr><td>19.2 Harmful when used long-term</td></tr><tr><td>19.3 Effective</td></tr><tr><td>19.4 Health consequences</td></tr><tr><td>19.5 Delays quitting process</td></tr><tr><td>22. Helpfulness of NRT</td><td>22.1 Recommend</td></tr><tr><td>23. Recommendation of cessation aids</td><td>23.2 Other forms of therapy</td></tr><tr><td rowspan="2">24. Stop smoking services</td><td>24.1 Advantages</td></tr><tr><td>24.2 Disadvantages</td></tr></table>
<table><tr><td>Theme</td><td>Sub-theme</td></tr><tr><td>1. Views on smoking</td><td>1.1 Hostility towards smoking</td></tr><tr><td rowspan="4">3. Reasons to quit smoking</td><td>3.1 To improve health</td></tr><tr><td>3.2 Social stigma</td></tr><tr><td>3.3 Saving money</td></tr><tr><td>3.4 Personal</td></tr><tr><td>4. Emotions connected with smoking initiation</td><td>4.1 Regret starting</td></tr><tr><td>6. B</td><td></td></tr></table>
<table><tr><td>Theme</td><td>Sub-theme</td></tr><tr><td rowspan="3">eliefs that influence quit attempts</td><td>6.1 Control of nicotine dependence</td></tr><tr><td>6.2 Motivation and willpower</td></tr><tr><td>6.3 Confidence</td></tr><tr><td>7. Difficulties quitting/cutting down</td><td>7.4 Lack of motivation</td></tr><tr><td>8. Goals</td><td>8.1 Smoking cessation</td></tr><tr><td rowspan="2">9. Methods used to quit smoking</td><td>9.1 Abrupt</td></tr><tr><td>9.2 Cut down first</td></tr><tr><td rowspan="3">10. Methods of cutting down</td><td>10.1 Not smoking as many cigarettes</td></tr><tr><td>10.2 Not smoking in the morning</td></tr><tr><td>10.3 Smoking only part of the cigarette</td></tr><tr><td rowspan="3">11. Non-medical aids to quit smoking</td><td>11.1 Distraction</td></tr><tr><td>11.2 Motivation</td></tr><tr><td>11.3 Exercising</td></tr><tr><td rowspan="3">12. Reasons for using NRT</td><td>12.1 To aid quit attempt</td></tr><tr><td>12.4 To help with cravings</td></tr><tr><td>12.5 Rid of habit</td></tr><tr><td rowspan="2">15. Factors to encourage use of NRT</td><td>15.1 Free samples</td></tr><tr><td>15.2 Aid quit attempt</td></tr><tr><td>16. Use of NRT</td><td>16.2 Incorrect use/underuse</td></tr><tr><td rowspan="2">17. Length of NRT use</td><td>17.1 Short-term</td></tr><tr><td>17.2 Long-term</td></tr><tr><td>18. Knowledge about NRT</td><td>18.1 Current regulations</td></tr><tr><td rowspan="5">19. Concerns about NRT</td><td>19.1 Addiction</td></tr><tr><td>19.2 Harmful when used long-term</td></tr><tr><td>19.3 Effective</td></tr><tr><td>19.4 Health consequences</td></tr><tr><td>19.5 Delays quitting process</td></tr><tr><td>22. Helpfulness of NRT</td><td>22.1 Recommend</td></tr><tr><td>23. Recommendation of cessation aids</td><td>23.2 Other forms of therapy</td></tr><tr><td rowspan="2">24. Stop smoking services</td><td>24.1 Advantages</td></tr><tr><td>24.2 Disadvantages</td></tr></table>
13dd984f942b854c9d1c89814d99d8bdd3ec2736f9dad46afb363982873af2cf.png
simple
<table><tr><td>2q23.1 deletion syndrome</td><td>SMS431*</td></tr><tr><td>Developmental delay</td><td>+</td></tr><tr><td>Motor delay</td><td>+</td></tr><tr><td>Language impairment</td><td>+</td></tr><tr><td>Behavioral problems</td><td>+</td></tr><tr><td>Autistic-like symptoms</td><td>+</td></tr><tr><td>Sleep disturbances</td><td>+</td></tr><tr><td>Repetitive behaviors (stereotypies)</td><td>+</td></tr><tr><td>Self-injurious behaviors</td><td>+</td></tr><tr><td>Short attention span</td><td>+</td></tr><tr><td>Aggression</td><td>+</td></tr><tr><td>Seizures</td><td>+</td></tr><tr><td>Infantile hypotonia</td><td>+</td></tr><tr><td>Infantile feeding difficulties</td><td>+</td></tr><tr><td>Eye abnormalities</td><td>+</td></tr><tr><td>Heavy arched eyebrows</td><td>-</td></tr><tr><td>Prominent nose</td><td>-</td></tr><tr><td>Thin upper lip</td><td>+</td></tr><tr><td>Widely spaced teeth</td><td>-</td></tr></table>
<table><tr><td>2q23.1 deletion syndrome</td><td>SMS431*</td></tr><tr><td>Developmental delay</td><td>+</td></tr><tr><td>Motor delay</td><td>+</td></tr><tr><td>Lan</td><td></td></tr></table>
<table><tr><td>guage impairment</td><td>+</td></tr><tr><td>Behavioral problems</td><td>+</td></tr><tr><td>Autistic-like symptoms</td><td>+</td></tr><tr><td>Sleep disturbances</td><td>+</td></tr><tr><td>Repetitive behaviors (stereotypies)</td><td>+</td></tr><tr><td>Self-injurious behaviors</td><td>+</td></tr><tr><td>Short attention span</td><td>+</td></tr><tr><td>Aggression</td><td>+</td></tr><tr><td>Seizures</td><td>+</td></tr><tr><td>Infantile hypotonia</td><td>+</td></tr><tr><td>Infantile feeding difficulties</td><td>+</td></tr><tr><td>Eye abnormalities</td><td>+</td></tr><tr><td>Heavy arched eyebrows</td><td>-</td></tr><tr><td>Prominent nose</td><td>-</td></tr><tr><td>Thin upper lip</td><td>+</td></tr><tr><td>Widely spaced teeth</td><td>-</td></tr></table>
7e2a5803c008dca7d36343d37a4562b50ac2e7d4bdd40715b20478af5997401d.png
complex
<table><tr><td></td><td></td><td></td><td>Differences</td><td>SD</td><td>Significance</td></tr><tr><td rowspan="10">Maxillomandibular relationship</td><td>Saggital</td><td>ANB(dg)</td><td>&#8722;0.113</td><td>0.146</td><td>0.065 NS</td></tr><tr><td></td><td>Wits(mm)</td><td>0.112</td><td>0.216</td><td>0.185 NS</td></tr><tr><td></td><td>overjet(mm)</td><td>&#8722;0.107</td><td>0.189</td><td>0.152 NS</td></tr><tr><td>Vertical</td><td>FMA(dg)</td><td>0.062</td><td>0.417</td><td>0.684 NS</td></tr><tr><td></td><td>Y-axis(dg)</td><td>0.100</td><td>0.141</td><td>0.085 NS</td></tr><tr><td></td><td>ANS-Me(mm)</td><td>0.200</td><td>0.634</td><td>0.402 NS</td></tr><tr><td></td><td>S-Go(mm)</td><td>0.200</td><td>0.160</td><td>0.010*</td></tr><tr><td></td><td>S-Go/N-Me</td><td>&#8722;0.001</td><td>0.002</td><td>0.906 NS</td></tr><tr><td></td><td>ANS-Me/N-Me</td><td>0.000</td><td>0.002</td><td>0.906 NS</td></tr><tr><td></td><td>overbite(mm)</td><td>&#8722;0.037</td><td>0.199</td><td>0.611 NS</td></tr><tr><td rowspan="6">Maxillary skeletal changes</td><td>Saggital</td><td>SNA(dg)</td><td>0.400</td><td>0.523</td><td>0.067 NS</td></tr><tr><td></td><td>ptm-A(mm)</td><td>0.312</td><td>0.083</td><td>0.036*</td></tr><tr><td></td><td>ptm-S(mm)</td><td>0.225</td><td>0.128</td><td>0.002**</td></tr><tr><td>Vertical</td><td>N-ANS(mm)</td><td>0.337</td><td>0.856</td><td>0.302 NS</td></tr><tr><td></td><td>PP-FH(dg)</td><td>0.087</td><td>0.339</td><td>0.490 NS</td></tr><tr><td></td><td>OP-SN(dg)</td><td>0.100</td><td>0.277</td><td>0.342 NS</td></tr><tr><td rowspan="7">Changes in maxillary dentition</td><td>Saggital</td><td>UI-NA(dg)</td><td>0.137</td><td>0.388</td><td>0.350 NS</td></tr><tr><td></td><td>UI-NA(mm)</td><td>0.037</td><td>0.272</td><td>0.708 NS</td></tr><tr><td></td><td>UI-AP(mm)</td><td>&#8722;0.142</td><td>0.440</td><td>0.700 NS</td></tr><tr><td></td><td>U6-PTM(mm)</td><td>0.312</td><td>0.318</td><td>0.027*</td></tr><tr><td></td><td>UI-SN(dg)</td><td>0.200</td><td>0.325</td><td>0.125 NS</td></tr><tr><td>Vertical</td><td>UI-PP(mm)</td><td>0.025</td><td>0.401</td><td>0.143 NS</td></tr><tr><td></td><td>U6-PP(mm)</td><td>0.137</td><td>0.184</td><td>0.073 NS</td></tr><tr><td rowspan="6">Changes in mandibular dentition</td><td>Saggital</td><td>LI-NB(dg)</td><td>&#8722;0.087</td><td>0.294</td><td>0.429 NS</td></tr><tr><td></td><td>LI-NB(mm)</td><td>&#8722;0.213</td><td>0.314</td><td>0.096 NS</td></tr><tr><td></td><td>LI-AP(mm)</td><td>&#8722;0.163</td><td>0.272</td><td>0.135 NS</td></tr><tr><td></td><td>FMIA(dg)</td><td>&#8722;0.25</td><td>0.239</td><td>0.021*</td></tr><tr><td>Vertical</td><td>LI-MP(mm)</td><td>0.187</td><td>0.325</td><td>0.064 NS</td></tr><tr><td></td><td>L6-MP(mm)</td><td>0.175</td><td>0.211</td><td>0.310 NS</td></tr><tr><td rowspan="6">Mandibular skeletal changes</td><td>Saggital</td><td>SNB(dg)</td><td>0.363</td><td>0.082</td><td>0.003**</td></tr><tr><td></td><td>Go-Pg(mm)</td><td>0.462</td><td>0.106</td><td>0.001**</td></tr><tr><td></td><td>Pcd-S(mm)</td><td>0.212</td><td>0.124</td><td>0.002**</td></tr><tr><td>Vertical</td><td>Go-Co(mm)</td><td>0.400</td><td>0.220</td><td>0.001***</td></tr><tr><td></td><td>MP-SN(dg)</td><td>0.237</td><td>0.106</td><td>0.000***</td></tr><tr><td></td><td>Y-axis(dg)</td><td>0.150</td><td>0.277</td><td>0.170 NS</td></tr><tr><td rowspan="6">Soft tissue changes</td><td></td><td>UL-EP(mm)</td><td>&#8722;0.225</td><td>0.116</td><td>0.001***</td></tr><tr><td></td><td>LL-EP(mm)</td><td>0.250</td><td>0.141</td><td>0.002**</td></tr><tr><td></td><td>Z-angel(dg)</td><td>&#8722;0.225</td><td>0.128</td><td>0.002**</td></tr><tr><td></td><td>UL-A&#8242;-FH(dg)</td><td>0.025</td><td>0.362</td><td>0.850 NS</td></tr><tr><td></td><td>N&#8242;-Pg&#8242;-FH(dg)</td><td>0.375</td><td>0.183</td><td>0.001***</td></tr><tr><td></td><td>N&#8242;-SN-Pg&#8242;(dg)</td><td>0.375</td><td>0.070</td><td>0.000***</td></tr></table>
<table><tr><td></td><td></td><td></td><td>Differences</td><td>SD</td><td>Significance</td></tr><tr><td rowspan="10">Maxillomandibular relationship</td><td>Saggital</td><td>ANB(dg)</td><td>−0.113</td><td>0.146</td><td>0.065 NS</td></tr><tr><td></td><td>Wits(mm)</td><td>0.112</td><td>0.216</td><td>0.185 NS</td></tr><tr><td></td><td>overjet(mm)</td><td>−0.107</td><td>0.189</td><td>0.152 NS</td></tr><tr><td>Vertical</td><td>FMA(dg)</td><td>0.062</td><td>0.417</td><td>0.684 NS</td></tr><tr><td></td><td>Y-axis(dg)</td><td>0.100</td><td>0.141</td><td>0.085 NS</td></tr><tr><td></td><td>ANS-Me(mm)</td><td>0.200</td><td>0.634</td><td>0.402 NS</td></tr><tr><td></td><td>S-Go(mm)</td><td>0.200</td><td>0.160</td><td>0.010*</td></tr><tr><td></td><td>S-Go/N-Me</td><td>−0.001</td><td>0.002</td><td>0.906 NS</td></tr><tr><td></td><td>ANS-Me/N-Me</td><td>0.000</td><td>0.002</td><td>0.906 NS</td></tr><tr><td></td><td>overbite(mm)</td><td>−0.037</td><td>0.199</td><td>0.611 NS</td></tr><tr><td rowspan="6">Maxillary skeletal changes</td><td>Saggital</td><td>SNA(dg)</td><td>0.400</td><td>0.523</td><td>0.067 NS</td></tr><tr><td></td><td>ptm-A(mm)</td><td>0.312</td><td>0.083</td><td>0.036*</td></tr><tr><td></td><td>ptm-S(mm)</td><td>0.225</td><td>0.128</td><td>0.002**</td></tr><tr><td>Vertical</td><td>N-ANS(mm)</td><td>0.337</td><td>0.856</td><td>0.302 NS</td></tr><tr><td></td><td>PP-FH(dg)</td><td>0.087</td><td>0.339</td><td>0.490 NS</td></tr><tr><td></td><td>OP-SN(dg)</td><td>0.100</td><td>0.277</td><td>0.342 NS</td></tr><tr><td rowspan="7">Changes in maxillary dentition</td><td>Saggital</td><td>UI-NA(dg)</td><td>0.137</td><td>0.388</td><td>0.350 NS</td></tr><tr><td></td><td>UI-NA(mm)</td><td>0.037</td><td>0.272</td><td>0.708 NS</td></tr><tr><td></td><td>UI-AP(mm)</td><td>−0.142</td><td>0.440</td><td>0.700 NS</td></tr><tr><td></td><td>U6-PTM(mm)</td><td>0.312</td><td>0.318</td><td>0.027*</td></tr><tr><td></td><td>UI-SN(dg)</td><td>0.200</td><td>0.325</td><td>0.125 NS</td></tr><tr><td>Vertical</td><td>UI-PP(mm)</td><td>0.025</td><td>0.401</td><td>0.143 NS</td></tr><tr><td></td><td>U6-PP(mm)</td><td>0.137</td><td>0.184</td><td>0.073 NS</td></tr><tr><td rowspan="6">Changes in mandibular dentition</td><td>Saggital</td><td>LI-NB(dg)</td><td>−0.087</td><td>0.294</td><td>0.429 NS</td></tr><tr><td></td><td>LI-NB(mm)</td><td>−0.213</td><td>0.314</td><td>0.096 NS</td></tr><tr><td></td><td>LI-AP(mm)</td><td>−0.163</td><td>0.272</td><td>0.135 NS</td></tr><tr><td></td><td>FMIA(dg)</td><td>−0.25</td><td>0.239</td><td>0.021*</td></tr><tr><td>Vertical</td><td>LI-MP(mm)</td><td>0.187</td><td>0.325</td><td>0.064 NS</td></tr><tr><td></td><td>L6-MP(mm)</td><td>0.175</td><td>0.211</td><td>0.310 NS</td></tr><tr><td rowspan="6">Mandibular skeletal changes</td><td>Saggital</td><td>SNB(dg)</td><td>0.363</td><td>0.082</td><td>0.003**</td></tr><tr><td></td><td>Go-Pg(mm)</td><td>0.462</td><td>0.106</td><td>0.001**</td></tr><tr><td></td><td>Pcd-S(mm)</td><td>0.212</td><td>0.124</td><td>0.002**</td></tr><tr><td>Vertical</td><td>Go-Co(mm)</td><td>0.400</td><td>0.220</td><td>0.001***</td></tr><tr><td></td><td>MP-SN(dg)</td><td>0.237</td><td>0.106</td><td>0.000***</td></tr><tr><td></td><td>Y-axis(dg)</td><td>0.150</td><td>0.277</td><td>0.170 NS</td></tr><tr><td rowspan="4">Soft tissue changes</td><td></td><td>UL-EP(mm)</td><td>−0.225</td><td>0.116</td><td>0.001***</td></tr><tr><td></td><td>LL-EP(mm)</td><td>0.250</td><td>0.141</td><td>0.002**</td></tr><tr><td></td><td>Z-angel(dg)</td><td>−0.225</td><td>0.128</td><td>0.002**</td></tr><tr><td></td><td>UL-A′-FH(dg)</td><td>0.025</td><td>0.362</td><td>0.850 NS</td></tr></table>
<table><tr><td rowspan="2">Soft tissue changes</td><td>N′-Pg′-FH(dg)</td><td>0.375</td><td>0.183</td><td>0.001***</td></tr><tr><td>N′-SN-Pg′(dg)</td><td>0.375</td><td>0.070</td><td>0.000***</td></tr></table>
1438eaa9035aef4eb735a898331e41260b8d2eba10078221cc0bb687ffea95bf.png
simple
<table><tr><td>Parameter</td><td>Measured and calculated values</td></tr><tr><td>Ash weight (g)</td><td>376.33</td></tr><tr><td>Char weight (g)</td><td>752.67</td></tr><tr><td>Tar weight (g)</td><td>73.58</td></tr><tr><td>Syngas flow rate (Nm<sup>3</sup>/hr)</td><td>16.02</td></tr><tr><td>Fuel consumption rate (kg/hr)</td><td>6.37</td></tr><tr><td>Gas yield (Nm<sup>3</sup>/kg)</td><td>2.51</td></tr><tr><td>Cold gas efficiency (%)</td><td>60.37</td></tr><tr><td>Mass conversion efficiency (%)</td><td>89.98</td></tr><tr><td>Carbon conversion efficiency (%)</td><td>91.18</td></tr></table>
<table><tr><td>Parameter</td><td>Measured and calculated values</td></tr><tr><td>Ash weight (g)</td><td>376.33</td></tr><tr><td>Char weight (g)</td><td>752.67</td></tr><tr><td>Tar weight (g)</td><td>73.58</td></tr><tr><td>Syngas flow rate (Nm3/hr)</td><td>16.02</td></tr><tr><td>Fuel consumption rate (kg/hr)</td><td>6.37</td></tr><tr><td>Gas yield (Nm3/kg)</td><td>2.51</td></tr><tr><td>Cold gas efficiency (%)</td><td>60.37</td></tr></table>
<table><tr><td>Mass conversion efficiency (%)</td><td>89.98</td></tr><tr><td>Carbon conversion efficiency (%)</td><td>91.18</td></tr></table>
7ab408131ae1a51efb57d74037995610b79ab1d735c093ceb2b8311f6a6d4d09.png
complex
<table><tr><td>Age (years)</td><td>Day of cycle before GnRHa therapy</td><td>Stage of endometriosis</td></tr><tr><td colspan="3">(a) Tissue for DIGE assay (n = 4)</td></tr><tr><td>33</td><td>15</td><td>IV</td></tr><tr><td>27</td><td>16</td><td>IV</td></tr><tr><td>27</td><td>18</td><td>IV</td></tr><tr><td>37</td><td>27</td><td>III</td></tr><tr><td colspan="3">(b) Tissue for WB assay (n = 10)</td></tr><tr><td>33</td><td>10</td><td>IV</td></tr><tr><td>25</td><td>14</td><td>IV</td></tr><tr><td>32</td><td>17</td><td>IV</td></tr><tr><td>29</td><td>13</td><td>III</td></tr><tr><td>27</td><td>15</td><td>IV</td></tr><tr><td>26</td><td>13</td><td>III</td></tr><tr><td>29</td><td>15</td><td>IV</td></tr><tr><td>23</td><td>11</td><td>IV</td></tr><tr><td>39</td><td>9</td><td>IV</td></tr><tr><td>36</td><td>12</td><td>III</td></tr></table>
<table><tr><td>Age (years)</td><td>Day of cycle before GnRHa therapy</td></tr><tr><td colspan="2">(a) Tissue for DIGE assay (n = 4)</td></tr><tr><td>33</td><td>15</td></tr><tr><td>27</td><td>16</td></tr><tr><td>27</td><td>18</td></tr><tr><td>37</td><td>27</td></tr><tr><td colspan="2">(b) Tissue for WB assay (n = 10)</td></tr><tr><td>33</td><td>10</td></tr><tr><td>25</td><td>14</td></tr><tr><td>32</td><td>17</td></tr><tr><td>29</td><td>13</td></tr><tr><td>27</td><td>15</td></tr><tr><td>26</td><td>13</td></tr><tr><td>29</td><td>15</td></tr><tr><td>23</td><td>11</td></tr><tr><td>39</td><td>9</td></tr><tr><td>36</td><td>12</td></tr></table>
<table><tr><td>Stage of endometriosis</td></tr><tr><td>(a) Tissue for DIGE assay (n = 4)</td></tr><tr><td>IV</td></tr><tr><td>IV</td></tr><tr><td>IV</td></tr><tr><td>III</td></tr><tr><td>(b) Tissue for WB assay (n = 10)</td></tr><tr><td>IV</td></tr><tr><td>IV</td></tr><tr><td>IV</td></tr><tr><td>III</td></tr><tr><td>IV</td></tr><tr><td>III</td></tr><tr><td>IV</td></tr><tr><td>IV</td></tr><tr><td>IV</td></tr><tr><td>III</td></tr></table>
f1663fbac11c4619672cef56821b8c29229d2a30c4c647c3a6d1d015949b49a4.png
complex
<table><tr><td>System</td><td> </td><td><i>&#945;</i>-Helix</td><td>Short segment</td><td><i>&#946;</i>-Turn</td></tr><tr><td rowspan="2">BSA</td><td>Frequency (cm<sup>&#8722;1</sup>)</td><td>1655</td><td>1642</td><td>1682</td></tr><tr><td>Content (%)</td><td>55.71</td><td>34.51</td><td>9.78</td></tr><tr><td rowspan="2">BSA-DIO</td><td>Frequency (cm<sup>&#8722;1</sup>)</td><td>1654</td><td>1639</td><td>1682</td></tr><tr><td>Content (%)</td><td>47.58</td><td>27.70</td><td>24.72</td></tr><tr><td rowspan="2">BSA-DIO-Co<sup>2+</sup></td><td>Frequency (cm<sup>&#8722;1</sup>)</td><td>1657</td><td>1639</td><td>1689</td></tr><tr><td>Content (%)</td><td>45.55</td><td>38.52</td><td>15.93</td></tr><tr><td rowspan="2">BSA-DIO-Zn<sup>2+</sup></td><td>Frequency (cm<sup>&#8722;1</sup>)</td><td>1657</td><td>1639</td><td>1685</td></tr><tr><td>Content (%)</td><td>51.48</td><td>38.30</td><td>10.22</td></tr></table>
<table><tr><td>System</td><td></td><td>α-Helix</td><td>Short segment</td><td>β-Turn</td></tr><tr><td rowspan="2">BSA</td><td>Frequency (cm−1)</td><td>1655</td><td>1642</td><td>1682</td></tr><tr><td>Content (%)</td><td>55.71</td><td>34.51</td><td>9.78</td></tr><tr><td rowspan="2">BSA-DIO</td><td>Frequency (cm−1)</td><td>1654</td><td>1639</td><td>1682</td></tr><tr><td>Content (%)</td><td>47.58</td><td>27.70</td><td>24.72</td></tr></table>
<table><tr><td rowspan="2">BSA-DIO-Co2+</td><td>Frequency (cm−1)</td><td>1657</td><td>1639</td><td>1689</td></tr><tr><td>Content (%)</td><td>45.55</td><td>38.52</td><td>15.93</td></tr><tr><td rowspan="2">BSA-DIO-Zn2+</td><td>Frequency (cm−1)</td><td>1657</td><td>1639</td><td>1685</td></tr><tr><td>Content (%)</td><td>51.48</td><td>38.30</td><td>10.22</td></tr></table>
4d81ab88a2750161c45ff93a49b663f606049730c2815f79a736eb4a84213245.png
complex
<table><tr><td rowspan="2">Age and gender</td><td rowspan="2">Population-at-risk</td><td colspan="4">Annual incidence (per 100,000 person-years) 2002&#8211;2014</td></tr><tr><td>Odontoid fractures</td><td>Hangman's fractures</td><td>Atypical fractures</td><td>Total</td></tr><tr><td>Men &lt;70</td><td>201,402</td><td>1.0</td><td>0.4</td><td>0.5</td><td>1.9</td></tr><tr><td>Women &lt;70</td><td>201,444</td><td>0.5</td><td>0.2</td><td>0.03</td><td>0.8</td></tr><tr><td>Men &#8805;70</td><td>28,713</td><td>15.8</td><td>0.8</td><td>1.3</td><td>17.9</td></tr><tr><td>Women &#8805;70</td><td>41,382</td><td>16.0</td><td>1.1</td><td>0.7</td><td>17.8</td></tr><tr><td>Total</td><td>472,941</td><td>3.0</td><td>0.4</td><td>0.4</td><td>3.8</td></tr></table>
<table><tr><td>Age and gender</td><td>Population-at-risk</td><td colspan="4">Annual incidence (per 100,000 person-years) 2002–2014</td></tr></table>
<table><tr><td>Age and gender</td><td>Population-at-risk</td><td>Odontoid fractures</td><td>Hangman's fractures</td><td>Atypical fractures</td><td>Total</td></tr><tr><td>Men <70</td><td>201,402</td><td>1.0</td><td>0.4</td><td>0.5</td><td>1.9</td></tr><tr><td>Women <70</td><td>201,444</td><td>0.5</td><td>0.2</td><td>0.03</td><td>0.8</td></tr><tr><td>Men ≥70</td><td>28,713</td><td>15.8</td><td>0.8</td><td>1.3</td><td>17.9</td></tr><tr><td>Women ≥70</td><td>41,382</td><td>16.0</td><td>1.1</td><td>0.7</td><td>17.8</td></tr><tr><td>Total</td><td>472,941</td><td>3.0</td><td>0.4</td><td>0.4</td><td>3.8</td></tr></table>
499b0e092f68aae9a603871cf9c14b121879f239c73c64021bc887566fed0930.png
complex
<table><tr><td>Parameter</td><td>Supplement group</td><td>Placebo group</td><td><i>P</i>-value supplement <i>vs</i> placebo (ANCOVA)</td></tr><tr><td colspan="4">CD4+: %</td></tr><tr><td> 0 days</td><td>17.69 &#177; 15.37</td><td>13.94 &#177; 11.62</td><td>&#8211;</td></tr><tr><td> 60 days</td><td>19.45 &#177; 15.14</td><td>14.69 &#177; 12.40</td><td>0.752</td></tr><tr><td> 180 days</td><td>23.57 &#177; 12.45</td><td>19.89 &#177; 11.12</td><td>0.861</td></tr><tr><td> 365 days</td><td>26.33 &#177; 9.95</td><td>24.07 &#177; 9.53</td><td>0.643</td></tr><tr><td colspan="4">CD8+: %</td></tr><tr><td> 0 days</td><td>12.60 &#177; 13.48</td><td>7.65 &#177; 8.63</td><td>&#8211;</td></tr><tr><td> 60 days</td><td>11.65 &#177; 10.40</td><td>8.16 &#177; 9.04</td><td>0.981</td></tr><tr><td> 180 days</td><td>13.72 &#177; 12.39</td><td>7.76 &#177; 5.38</td><td>0.578</td></tr><tr><td> 365 days</td><td>12.44 &#177; 6.76</td><td>10.76 &#177; 6.33</td><td>0.546</td></tr><tr><td colspan="4">CD4+/CD8+ ratio</td></tr><tr><td> 0 days</td><td>2.01 &#177; 1.39</td><td>2.80 &#177; 1.90</td><td>&#8211;</td></tr><tr><td> 60 days</td><td>2.41 &#177; 2.12</td><td>2.31 &#177; 1.33</td><td>0.394</td></tr><tr><td> 180 days</td><td>3.10 &#177; 3.15</td><td>2.92 &#177; 1.50</td><td>0.238</td></tr><tr><td> 365 days</td><td>3.21 &#177; 3.43</td><td>2.75 &#177; 1.11</td><td>0.721</td></tr><tr><td colspan="4">IL-6: pg/ml</td></tr><tr><td> 0 days</td><td>382.91 &#177; 940.53</td><td>269.95 &#177; 1054.1</td><td>&#8211;</td></tr><tr><td> 60 days</td><td>138.65 &#177; 371.02</td><td>393.12 &#177; 1424.6</td><td>0.165</td></tr><tr><td> 180 days</td><td>192.38 &#177; 456.17</td><td>118.67 &#177; 184.77</td><td>0.728</td></tr><tr><td> 365 days</td><td>314.92 &#177; 1024.5</td><td>34.63 &#177; 55.48</td><td>0.612</td></tr><tr><td colspan="4">IL-10: pg/ml</td></tr><tr><td> 0 days</td><td>22.69 &#177; 76.01</td><td>17.92 &#177; 63.47</td><td>&#8211;</td></tr><tr><td> 60 days</td><td>7.52 &#177; 12.67</td><td>38.51 &#177; 147.25</td><td>0.208</td></tr><tr><td> 180 days</td><td>4.33 &#177; 4.34</td><td>69.35 &#177; 231.80</td><td>0.172</td></tr><tr><td> 365 days</td><td>6.53 &#177; 10.01</td><td>2.68 &#177; 0.74</td><td>0.282</td></tr><tr><td colspan="4">TNF-&#945;: pg/ml</td></tr><tr><td> 0 days</td><td>123.14 &#177; 292.94</td><td>81.58 &#177; 308.77</td><td>&#8211;</td></tr><tr><td> 60 days</td><td>40.47 &#177; 95.60</td><td>112.17 &#177; 397.27</td><td>0.150</td></tr><tr><td> 180 days</td><td>59.21 &#177; 144.19</td><td>44.82 &#177; 72.46</td><td>0.811</td></tr><tr><td> 365 days</td><td>73.11 &#177; 233.46</td><td>13.23 &#177; 19.81</td><td>0.597</td></tr><tr><td colspan="4">IFN-&#947;: pg/ml</td></tr><tr><td> 0 days</td><td>15.97 &#177; 35.87</td><td>3.49 &#177; 8.12</td><td>&#8211;</td></tr><tr><td> 60 days</td><td>7.04 &#177; 13.64</td><td>1.39 &#177; 2.33</td><td>0.264</td></tr><tr><td> 180 days</td><td>0.81 &#177; 0.84</td><td>0.84 &#177; 0.42</td><td>0.980</td></tr><tr><td> 365 days</td><td>4.58 &#177; 13.43</td><td>1.30 &#177; 0.97</td><td>0.544</td></tr></table>
<table><tr><td>Parameter</td><td>Supplement group</td><td>Placebo group</td><td>P-value supplement vs placebo (ANCOVA)</td></tr><tr><td colspan="4">CD4+: %</td></tr><tr><td>0 days</td><td>17.69 ± 15.37</td><td>13.94 ± 11.62</td><td>–</td></tr><tr><td>60 days</td><td>19.45 ± 15.14</td><td>14.69 ± 12.40</td><td>0.752</td></tr><tr><td>180 days</td><td>23.57 ± 12.45</td><td>19.89 ± 11.12</td><td>0.861</td></tr><tr><td>365 days</td><td>26.33 ± 9.95</td><td>24.07 ± 9.53</td><td>0.643</td></tr><tr><td colspan="4">CD8+: %</td></tr></table>
<table><tr><td>0 days</td><td>12.60 ± 13.48</td><td>7.65 ± 8.63</td><td>–</td></tr><tr><td>60 days</td><td>11.65 ± 10.40</td><td>8.16 ± 9.04</td><td>0.981</td></tr><tr><td>180 days</td><td>13.72 ± 12.39</td><td>7.76 ± 5.38</td><td>0.578</td></tr><tr><td>365 days</td><td>12.44 ± 6.76</td><td>10.76 ± 6.33</td><td>0.546</td></tr><tr><td colspan="4">CD4+/CD8+ ratio</td></tr><tr><td>0 days</td><td>2.01 ± 1.39</td><td>2.80 ± 1.90</td><td>–</td></tr><tr><td>60 days</td><td>2.41 ± 2.12</td><td>2.31 ± 1.33</td><td>0.394</td></tr><tr><td>180 days</td><td>3.10 ± 3.15</td><td>2.92 ± 1.50</td><td>0.238</td></tr><tr><td>365 days</td><td>3.21 ± 3.43</td><td>2.75 ± 1.11</td><td>0.721</td></tr><tr><td colspan="4">IL-6: pg/ml</td></tr><tr><td>0 days</td><td>382.91 ± 940.53</td><td>269.95 ± 1054.1</td><td>–</td></tr><tr><td>60 days</td><td>138.65 ± 371.02</td><td>393.12 ± 1424.6</td><td>0.165</td></tr><tr><td>180 days</td><td>192.38 ± 456.17</td><td>118.67 ± 184.77</td><td>0.728</td></tr><tr><td>365 days</td><td>314.92 ± 1024.5</td><td>34.63 ± 55.48</td><td>0.612</td></tr><tr><td colspan="4">IL-10: pg/ml</td></tr><tr><td>0 days</td><td>22.69 ± 76.01</td><td>17.92 ± 63.47</td><td>–</td></tr><tr><td>60 days</td><td>7.52 ± 12.67</td><td>38.51 ± 147.25</td><td>0.208</td></tr><tr><td>180 days</td><td>4.33 ± 4.34</td><td>69.35 ± 231.80</td><td>0.172</td></tr><tr><td>365 days</td><td>6.53 ± 10.01</td><td>2.68 ± 0.74</td><td>0.282</td></tr><tr><td colspan="4">TNF-α: pg/ml</td></tr><tr><td>0 days</td><td>123.14 ± 292.94</td><td>81.58 ± 308.77</td><td>–</td></tr><tr><td>60 days</td><td>40.47 ± 95.60</td><td>112.17 ± 397.27</td><td>0.150</td></tr><tr><td>180 days</td><td>59.21 ± 144.19</td><td>44.82 ± 72.46</td><td>0.811</td></tr><tr><td>365 days</td><td>73.11 ± 233.46</td><td>13.23 ± 19.81</td><td>0.597</td></tr><tr><td colspan="4">IFN-γ: pg/ml</td></tr><tr><td>0 days</td><td>15.97 ± 35.87</td><td>3.49 ± 8.12</td><td>–</td></tr><tr><td>60 days</td><td>7.04 ± 13.64</td><td>1.39 ± 2.33</td><td>0.264</td></tr><tr><td>180 days</td><td>0.81 ± 0.84</td><td>0.84 ± 0.42</td><td>0.980</td></tr><tr><td>365 days</td><td>4.58 ± 13.43</td><td>1.30 ± 0.97</td><td>0.544</td></tr></table>
e0455f050b74b9c964bf1855a16a2feaa2986a2113e665e228242248aabba082.png
simple
<table><tr><td> </td><td>Multivariate odds ratio<sup>3</sup></td><td>95% Confidence interval for OR</td><td>P-value</td></tr><tr><td>Postmenopausal (1 = yes, 0 = no)</td><td>0.120</td><td>0.069 &#8211; 0.207</td><td>&lt;0.001</td></tr><tr><td>% Body fat &gt; cut-off(1 = yes, 0 = no)</td><td>0.414</td><td>0.297 &#8211; 0.578</td><td>&lt;0.001</td></tr><tr><td>hs-CRP<sup>2</sup> (1 = 3-10 mg/L, 0 = &lt;3 mg/L)</td><td>0.571</td><td>0.369 &#8211; 0.884</td><td>0.012</td></tr><tr><td>RBC LC-PUFA,% <i>of total fatty acids</i></td><td>0.896</td><td>0.793 &#8211; 1.012</td><td>0.068</td></tr><tr><td>Oral contraceptive use (1 = yes, 0 = no)</td><td>0.426</td><td>0.262 &#8211; 0.693</td><td>0.078</td></tr><tr><td>Food insecure (1 = yes, 0 = no)</td><td>1.37</td><td>0.98 &#8211; 1.92</td><td>0.001</td></tr><tr><td>Food insecure* RBC LC-PUFA</td><td>0.842</td><td>0.721 &#8211; 0.984</td><td>0.030</td></tr></table>
<table><tr><td></td><td>Multivariate odds ratio3</td><td>95% Confidence interval for OR</td><td>P-value</td></tr><tr><td>Postmenopausal (1 = yes, 0 = no)</td><td>0.120</td><td>0.069 – 0.207</td><td><0.001</td></tr><tr><td>% Body fat > cut-off(1 = yes, 0 = no)</td><td>0.414</td><td>0.297 – 0.578</td><td><0.001</td></tr><tr><td>hs-CRP2 (1 = 3-10 mg/L, 0 = <3 mg/L)</td><td>0.571</td><td>0.369 – 0.884</td><td>0.012</td></tr><tr><td>RBC LC-PUFA,% of total fatty acids</td><td>0.896</td><td>0.793 – 1.012</td><td>0.068</td></tr><tr><td>Oral contraceptive use (1 = yes, 0 = no)</td><td>0.426</td><td>0.262 – 0.693</td><td>0.078</td></tr><tr><td>Food insecure (1 = yes, 0 = no)</td><td>1.37</td><td>0.98 – 1.92</td><td>0.001</td></tr></table>
<table><tr><td>Food insecure* RBC LC-PUFA</td><td>0.842</td><td>0.721 – 0.984</td><td>0.030</td></tr></table>
07e1a6642ce9dfebc53872894069f7a8f35929153423e4db546c03816080f58f.png
simple
<table><tr><td></td><td>40-49</td><td>50-69</td><td>Total (40-69)</td></tr><tr><td>Women invited</td><td>56,888</td><td>63,552</td><td>120,440</td></tr><tr><td>Observed one-year participation rate</td><td>32.6%</td><td>30.6%</td><td>31.6%</td></tr><tr><td>Estimated one-year participation rate</td><td>37.1%</td><td>35.1%</td><td>36.1%</td></tr><tr><td>Observed two-year participation rate</td><td>55.1%</td><td>50.3%</td><td>52.5%</td></tr><tr><td>Estimated two-year participation rate</td><td>59.6%</td><td>54.8%</td><td>57.0%</td></tr></table>
<table><tr><td></td><td>40-49</td><td>50-69</td><td>Total (40-69)</td></tr><tr><td>Women invited</td><td>56,888</td><td>63,552</td><td>120,440</td></tr></table>
<table><tr><td>Observed one-year participation rate</td><td>32.6%</td><td>30.6%</td><td>31.6%</td></tr><tr><td>Estimated one-year participation rate</td><td>37.1%</td><td>35.1%</td><td>36.1%</td></tr><tr><td>Observed two-year participation rate</td><td>55.1%</td><td>50.3%</td><td>52.5%</td></tr><tr><td>Estimated two-year participation rate</td><td>59.6%</td><td>54.8%</td><td>57.0%</td></tr></table>
c2303210a4a023daa72685977f21da3de555c8d985cf385fb1654fa7ae5dc715.png
simple
<table><tr><td>Inhibitors</td><td>Target</td><td>Anti&#8208;CSC activity</td></tr><tr><td>Tenovin&#8208;6</td><td>SIRT1/2</td><td>CML, AML</td></tr><tr><td>BDF4&#8208;1, &#8208;2a, &#8208;2b, &#8208;2d</td><td>SIRT1/2</td><td>Colon, glioblastoma</td></tr><tr><td>AGK2</td><td>SIRT2</td><td>Glioblastoma</td></tr><tr><td>Salermide</td><td>SIRT1/2</td><td>Colorectal</td></tr><tr><td>Inhibitors</td><td>Target</td><td>Anticancer activity</td></tr><tr><td>Nicotinamide</td><td>SIRT1/2/3/5/6</td><td>Leukemia, oral, prostate</td></tr><tr><td>Sirtinol</td><td>SIRT2</td><td>Breast, lung, prostate, oral</td></tr><tr><td>Salermide</td><td>SIRT1/2</td><td>Lung, breast, colon</td></tr><tr><td>JGB&#8208;1741</td><td>SIRT1</td><td>Breast</td></tr><tr><td>Cambinol</td><td>SIRT1/2/5</td><td>Burkitt lymphoma</td></tr><tr><td>EX527</td><td>SIRT1</td><td>Leukemia</td></tr><tr><td>AC&#8208;93253</td><td>SIRT1/2/3</td><td>Prostate, pancreas, lung</td></tr><tr><td>Inauhzin</td><td>SIRT1</td><td>Lung, colon</td></tr><tr><td>Tenovin&#8208;1</td><td>Unknown</td><td>Burkitt lymphoma, melanoma</td></tr></table>
<table><tr><td>Inhibitors</td><td>Target</td><td>Anti‐CSC activity</td></tr><tr><td>Tenovin‐6</td><td>SIRT1/2</td><td>CML, AML</td></tr><tr><td>BDF4‐1, ‐2a, ‐2b, ‐2d</td><td>SIRT1/2</td><td>Colon, glioblastoma</td></tr><tr><td>AGK2</td><td>SIRT2</td><td>Glioblastoma</td></tr><tr><td>Salermide</td><td>SIRT1/2</td><td>Colorectal</td></tr><tr><td>Inhibitors</td><td>Target</td><td>Anticancer activity</td></tr><tr><td>Nicotinamide</td><td>SIRT1/2/3/5/6</td><td>Leukemia, oral, prostate</td></tr></table>
<table><tr><td>Sirtinol</td><td>SIRT2</td><td>Breast, lung, prostate, oral</td></tr><tr><td>Salermide</td><td>SIRT1/2</td><td>Lung, breast, colon</td></tr><tr><td>JGB‐1741</td><td>SIRT1</td><td>Breast</td></tr><tr><td>Cambinol</td><td>SIRT1/2/5</td><td>Burkitt lymphoma</td></tr><tr><td>EX527</td><td>SIRT1</td><td>Leukemia</td></tr><tr><td>AC‐93253</td><td>SIRT1/2/3</td><td>Prostate, pancreas, lung</td></tr><tr><td>Inauhzin</td><td>SIRT1</td><td>Lung, colon</td></tr><tr><td>Tenovin‐1</td><td>Unknown</td><td>Burkitt lymphoma, melanoma</td></tr></table>
bf573e9a5dd221992d051dd23cd9acc35101caf1e3c9ecd1d602f30b7eebe225.png
complex
<table><tr><td></td><td colspan="2">H5N1</td><td colspan="3">H1N1</td><td colspan="2">H7N9</td></tr><tr><td>Residues</td><td>Avian</td><td>Human</td><td>Avian</td><td colspan="2">Human</td><td>Avian</td><td>Human</td></tr><tr><td></td><td></td><td></td><td></td><td>Then-2009/03</td><td>2009/04-Now</td><td></td><td></td></tr><tr><td>470K</td><td>2712</td><td>227</td><td>493</td><td>113</td><td>8127</td><td>98</td><td>494</td></tr><tr><td>470R</td><td>0</td><td>0</td><td>1</td><td>1421</td><td>87</td><td>0</td><td>0</td></tr></table>
<table><tr><td></td><td colspan="2">H5N1</td><td colspan="3">H1N1</td><td colspan="2">H7N9</td></tr><tr><td>Residues</td><td>Avian</td><td>Human</td><td>Avian</td><td colspan="2">Human</td><td>Avian</td><td>Human</td></tr><tr><td></td><td></td><td></td><td></td><td>Then-2009/03</td><td>2009/04-Now</td><td></td><td></td></tr><tr><td>470K</td><td>2712</td><td>227</td><td>493</td><td>113</td><td>8127</td><td>98</td><td>494</td></tr></table>
<table><tr><td></td><td colspan="2">H5N1</td><td colspan="3">H1N1</td><td colspan="2">H7N9</td></tr><tr><td>Residues</td><td>Avian</td><td>Human</td><td>Avian</td><td colspan="2">Human</td><td>Avian</td><td>Human</td></tr><tr><td>470R</td><td>0</td><td>0</td><td>1</td><td>1421</td><td>87</td><td>0</td><td>0</td></tr></table>
2a39354c49749a5ad60a74e4493b85788b12b73f68288060553244294435677a.png
complex
<table><tr><td>Characteristics</td><td colspan="2">Partial colectomy (N=9352)</td><td colspan="2">Hemicolectomy (N=18758)</td><td>P</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> Male</td><td>3663</td><td>39.2%</td><td>6749</td><td>36.0%</td><td></td></tr><tr><td> Female</td><td>5689</td><td>60.8%</td><td>12009</td><td>64.0%</td><td></td></tr><tr><td>Race</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> Black</td><td>544</td><td>5.8%</td><td>1229</td><td>6.6%</td><td></td></tr><tr><td> White</td><td>7971</td><td>85.3%</td><td>16458</td><td>87.7%</td><td></td></tr><tr><td> Others</td><td>837</td><td>8.9%</td><td>1071</td><td>5.7%</td><td></td></tr><tr><td>AJCC Stage</td><td></td><td></td><td></td><td></td><td>0.002</td></tr><tr><td> Stage I</td><td>2338</td><td>25.0%</td><td>4327</td><td>23.1%</td><td></td></tr><tr><td> Stage II</td><td>4021</td><td>43.0%</td><td>8275</td><td>44.1%</td><td></td></tr><tr><td> Stage III</td><td>2993</td><td>32.0%</td><td>6156</td><td>32.8%</td><td></td></tr><tr><td>AJCC T stage</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> T1/T2</td><td>2641</td><td>28.2%</td><td>4905</td><td>26.1%</td><td></td></tr><tr><td> T3/T4</td><td>6711</td><td>71.8%</td><td>13853</td><td>73.9%</td><td></td></tr><tr><td>AJCC N stage</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> N0</td><td>6359</td><td>68.0%</td><td>12602</td><td>67.2%</td><td></td></tr><tr><td> N1</td><td>2042</td><td>21.8%</td><td>3902</td><td>20.8%</td><td></td></tr><tr><td> N2</td><td>951</td><td>10.2%</td><td>2254</td><td>12.0%</td><td></td></tr><tr><td>Grade</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> Grade I/II</td><td>7514</td><td>80.3%</td><td>13595</td><td>72.4%</td><td></td></tr><tr><td> Grade III/IV</td><td>1623</td><td>17.4%</td><td>4739</td><td>25.3%</td><td></td></tr><tr><td> Unknown</td><td>215</td><td>2.3%</td><td>424</td><td>2.3%</td><td></td></tr><tr><td>Tumor location</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> Right sided colon cancer</td><td>4035</td><td>43.1%</td><td>16619</td><td>88.6%</td><td></td></tr><tr><td> Left sided colon cancer</td><td>5317</td><td>56.9%</td><td>2139</td><td>11.4%</td><td></td></tr><tr><td>Histology</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> Adenocarcinoma</td><td>8386</td><td>89.7%</td><td>15995</td><td>85.3%</td><td></td></tr><tr><td> Mucous Tumor</td><td>900</td><td>9.6%</td><td>2571</td><td>13.7%</td><td></td></tr><tr><td> Others</td><td>66</td><td>0.7%</td><td>192</td><td>1.0%</td><td></td></tr><tr><td>Tumor size (cm)</td><td></td><td></td><td></td><td></td><td>&lt;0.001</td></tr><tr><td> 0-5</td><td>5511</td><td>58.9%</td><td>9850</td><td>52.5%</td><td></td></tr><tr><td> &#8805;5</td><td>3841</td><td>41.1%</td><td>8908</td><td>47.5%</td><td></td></tr></table>
<table><tr><td>Characteristics</td><td colspan="2">Partial colectomy (N=9352)</td><td colspan="2">Hemicolectomy (N=18758)</td><td>P</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>Male</td><td>3663</td><td>39.2%</td><td>6749</td><td>36.0%</td><td></td></tr><tr><td>Female</td><td>5689</td><td>60.8%</td><td>12009</td><td>64.0%</td><td></td></tr><tr><td>Race</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>Black</td><td>544</td><td>5.8%</td><td>1229</td><td>6.6%</td><td></td></tr><tr><td>White</td><td>7971</td><td>85.3%</td><td>16458</td><td>87.7%</td><td></td></tr><tr><td>Others</td><td>837</td><td>8.9%</td><td>1071</td><td>5.7%</td><td></td></tr><tr><td>AJCC Stage</td><td></td><td></td><td></td><td></td><td>0.002</td></tr><tr><td>Stage I</td><td>2338</td><td>25.0%</td><td>4327</td><td>23.1%</td><td></td></tr></table>
<table><tr><td>Stage II</td><td>4021</td><td>43.0%</td><td>8275</td><td>44.1%</td><td></td></tr><tr><td>Stage III</td><td>2993</td><td>32.0%</td><td>6156</td><td>32.8%</td><td></td></tr><tr><td>AJCC T stage</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>T1/T2</td><td>2641</td><td>28.2%</td><td>4905</td><td>26.1%</td><td></td></tr><tr><td>T3/T4</td><td>6711</td><td>71.8%</td><td>13853</td><td>73.9%</td><td></td></tr><tr><td>AJCC N stage</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>N0</td><td>6359</td><td>68.0%</td><td>12602</td><td>67.2%</td><td></td></tr><tr><td>N1</td><td>2042</td><td>21.8%</td><td>3902</td><td>20.8%</td><td></td></tr><tr><td>N2</td><td>951</td><td>10.2%</td><td>2254</td><td>12.0%</td><td></td></tr><tr><td>Grade</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>Grade I/II</td><td>7514</td><td>80.3%</td><td>13595</td><td>72.4%</td><td></td></tr><tr><td>Grade III/IV</td><td>1623</td><td>17.4%</td><td>4739</td><td>25.3%</td><td></td></tr><tr><td>Unknown</td><td>215</td><td>2.3%</td><td>424</td><td>2.3%</td><td></td></tr><tr><td>Tumor location</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>Right sided colon cancer</td><td>4035</td><td>43.1%</td><td>16619</td><td>88.6%</td><td></td></tr><tr><td>Left sided colon cancer</td><td>5317</td><td>56.9%</td><td>2139</td><td>11.4%</td><td></td></tr><tr><td>Histology</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>Adenocarcinoma</td><td>8386</td><td>89.7%</td><td>15995</td><td>85.3%</td><td></td></tr><tr><td>Mucous Tumor</td><td>900</td><td>9.6%</td><td>2571</td><td>13.7%</td><td></td></tr><tr><td>Others</td><td>66</td><td>0.7%</td><td>192</td><td>1.0%</td><td></td></tr><tr><td>Tumor size (cm)</td><td></td><td></td><td></td><td></td><td><0.001</td></tr><tr><td>0-5</td><td>5511</td><td>58.9%</td><td>9850</td><td>52.5%</td><td></td></tr><tr><td>≥5</td><td>3841</td><td>41.1%</td><td>8908</td><td>47.5%</td><td></td></tr></table>
1dc293bbe76a8e8a201201d36295a81a41def771492e1f41e83981eb432b10e8.png
complex
<table><tr><td></td><td colspan="3">Female: egg or central cell</td><td colspan="3">Male: pollen or sperm</td><td colspan="3">F<sub>1</sub>progeny</td><td colspan="2">F<sub>1</sub>progeny</td></tr><tr><td></td><td colspan="3">CHX</td><td colspan="3">CHX</td><td colspan="3">CHX</td><td>Expect</td><td>Obs</td></tr><tr><td></td><td>17</td><td>18</td><td>19</td><td>17</td><td>18</td><td>19</td><td>17</td><td>18</td><td>19</td><td>(%)</td><td>(%)</td></tr><tr><td>a</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;/&#8211;</td><td>+/+</td><td>&#8211;/&#8211;</td><td>50</td><td>62 (95)</td></tr><tr><td></td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;/&#8211;</td><td>+/&#8211;</td><td>&#8211;/&#8211;</td><td>50</td><td>3 (5)</td></tr><tr><td>b</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;/&#8211;</td><td>+/+</td><td>&#8211;/&#8211;</td><td>50</td><td>98 (70)</td></tr><tr><td></td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;/&#8211;</td><td>+/&#8211;</td><td>&#8211;/&#8211;</td><td>50</td><td>41 (30)</td></tr><tr><td>c</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;/&#8211;</td><td>&#8211;/&#8211;</td><td>+/+</td><td>50</td><td>92 (97)</td></tr><tr><td></td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;/&#8211;</td><td>&#8211;/&#8211;</td><td>+/&#8211;</td><td>50</td><td>3 (3)</td></tr><tr><td>d</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;/&#8211;</td><td>&#8211;/&#8211;</td><td>+/+</td><td>50</td><td>69 (75)</td></tr><tr><td></td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>&#8211;</td><td>+</td><td>&#8211;/&#8211;</td><td>&#8211;/&#8211;</td><td>+/&#8211;</td><td>50</td><td>23 (25)</td></tr></table>
<table><tr><td></td><td colspan="3">Female: egg or central cell</td><td colspan="3">Male: pollen or sperm</td><td colspan="2">F1progeny</td></tr><tr><td></td><td colspan="3">CHX</td><td colspan="3">CHX</td><td colspan="2">CHX</td></tr><tr><td></td><td>17</td><td>18</td><td>19</td><td>17</td><td>18</td><td>19</td><td>17</td><td>18</td></tr><tr><td>a</td><td>–</td><td>+</td><td>–</td><td>–</td><td>+</td><td>–</td><td>–/–</td><td>+/+</td></tr><tr><td></td><td>–</td><td>+</td><td>–</td><td>–</td><td>–</td><td>–</td><td>–/–</td><td>+/–</td></tr><tr><td>b</td><td>–</td><td>+</td><td>–</td><td>–</td><td>+</td><td>–</td><td>–/–</td><td>+/+</td></tr><tr><td></td><td>–</td><td>–</td><td>–</td><td>–</td><td>+</td><td>–</td><td>–/–</td><td>+/–</td></tr><tr><td>c</td><td>–</td><td>–</td><td>+</td><td>–</td><td>–</td><td>+</td><td>–/–</td><td>–/–</td></tr><tr><td></td><td>–</td><td>–</td><td>+</td><td>–</td><td>–</td><td>–</td><td>–/–</td><td>–/–</td></tr><tr><td>d</td><td>–</td><td>–</td><td>+</td><td>–</td><td>–</td><td>+</td><td>–/–</td><td>–/–</td></tr><tr><td></td><td>–</td><td>–</td><td>–</td><td>–</td><td>–</td><td>+</td><td>–/–</td><td>–/–</td></tr></table>
<table><tr><td>F1progeny</td><td colspan="2">F1progeny</td></tr><tr><td>CHX</td><td>Expect</td><td>Obs</td></tr><tr><td>19</td><td>(%)</td><td>(%)</td></tr><tr><td>–/–</td><td>50</td><td>62 (95)</td></tr><tr><td>–/–</td><td>50</td><td>3 (5)</td></tr><tr><td>–/–</td><td>50</td><td>98 (70)</td></tr><tr><td>–/–</td><td>50</td><td>41 (30)</td></tr><tr><td>+/+</td><td>50</td><td>92 (97)</td></tr><tr><td>+/–</td><td>50</td><td>3 (3)</td></tr><tr><td>+/+</td><td>50</td><td>69 (75)</td></tr><tr><td>+/–</td><td>50</td><td>23 (25)</td></tr></table>
19587a0fee215732cc4b37d6c34b2f3b5ece55ca47ebf4d08a695b0956cf77fc.png
complex
<table><tr><td>Factor</td><td>MPT &#8805;9 s <i>n</i> (%)</td><td>MPT &lt;9 s <i>n</i> (%)</td><td>Significance</td></tr><tr><td colspan="4">Method of RLN reconstruction</td></tr><tr><td> Direct anastomosis</td><td>33 (94.3)</td><td>2 (5.7)</td><td rowspan="3">N.S.</td></tr><tr><td> Ansa cervicalis-RLN anastomosis</td><td>152 (86.9)</td><td>23 (13.1)</td></tr><tr><td> Free nerve grafting</td><td>12 (80.0)</td><td>3 (20.0)</td></tr><tr><td colspan="4">VCP preoperatively</td></tr><tr><td> Yes</td><td>92 (88.5)</td><td>12 (11.5)</td><td rowspan="2">N.S.</td></tr><tr><td> No</td><td>108 (87.5)</td><td>16 (12.9)</td></tr><tr><td colspan="4">Site of distal anastomosis</td></tr><tr><td> Outside</td><td>146 (87.4)</td><td>21 (12.6)</td><td rowspan="2">N.S.</td></tr><tr><td> Inside</td><td>54 (88.5)</td><td>7 (11.5)</td></tr></table>
<table><tr><td>Factor</td><td>MPT ≥9 s n (%)</td><td>MPT <9 s n (%)</td><td>Significance</td></tr><tr><td colspan="4">Method of RLN reconstruction</td></tr><tr><td>Direct anastomosis</td><td>33 (94.3)</td><td>2 (5.7)</td><td rowspan="3">N.S.</td></tr><tr><td>Ansa cervicalis-RLN anastomosis</td><td>152 (86.9)</td><td>23 (13.1)</td></tr><tr><td>Free nerve grafting</td><td>12 (80.0)</td><td>3 (20.0)</td></tr><tr><td colspan="4">VCP preoperatively</td></tr><tr><td>Yes</td><td>92 (88.5)</td><td>12 (11.5)</td><td rowspan="2">N.S.</td></tr><tr><td>No</td><td>108 (87.5)</td><td>16 (12.9)</td></tr><tr><td colspan="4">Site of distal anastomosis</td></tr><tr><td>Outside</td><td>146 (87.4)</td><td>21 (12.6)</td><td>N.S.</td></tr></table>
<table><tr><td>Inside</td><td>54 (88.5)</td><td>7 (11.5)</td><td>N.S.</td></tr></table>
28e31e37d938f563ed8b4688a1225cc61e88c6e31f6a8094a1cdd7feda256dee.png
simple
<table><tr><td>Groups</td><td>MAP (mmHg)</td><td>Herat rate (bpm)</td><td>LVSP (mmHg)</td><td>LVEDP (mmHg)</td><td>LV dP/dt/P (1/sec)</td></tr><tr><td>N = 6</td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Control</td><td>107&#177;6</td><td>255&#177;5</td><td>125&#177;7</td><td>6.3&#177;1.1</td><td>64&#177;2.3</td></tr><tr><td>Sham</td><td>106&#177;6</td><td>249&#177;10</td><td>117&#177;4</td><td>5.6&#177;0.9</td><td>60&#177;1.4</td></tr><tr><td>Isoproterenol (Iso)</td><td>66&#177;6<sup>b</sup></td><td>323&#177;15<sup>a</sup></td><td>72&#177;9<sup>c</sup></td><td>21&#177;1.2<sup>c</sup></td><td>38&#177;9.1<sup>b</sup></td></tr><tr><td><i>O. basilicum </i>(10 mg/kg) + Iso</td><td>78&#177;6</td><td>285&#177;19</td><td>95&#177;4</td><td>5.8&#177;1.1***</td><td>69&#177;4.5**</td></tr><tr><td><i>O. basilicum </i>(20 mg/kg) + Iso</td><td>90&#177;11</td><td>294&#177;21</td><td>109&#177;10**</td><td>9.0&#177;3.4***</td><td>73&#177;4.6***</td></tr><tr><td><i>O. basilicum </i>(40 mg/kg) + Iso</td><td>113&#177;4***</td><td>312&#177;16</td><td>127&#177;3***</td><td>6.6&#177;1.5***</td><td>95&#177;2.8***</td></tr></table>
<table><tr><td>Groups</td><td>MAP (mmHg)</td><td>Herat rate (bpm)</td><td>LVSP (mmHg)</td><td>LVEDP (mmHg)</td></tr><tr><td>N = 6</td><td></td><td></td><td></td><td></td></tr><tr><td>Control</td><td>107±6</td><td>255±5</td><td>125±7</td><td>6.3±1.1</td></tr><tr><td>Sham</td><td>106±6</td><td>249±10</td><td>117±4</td><td>5.6±0.9</td></tr><tr><td>Isoproterenol (Iso)</td><td>66±6b</td><td>323±15a</td><td>72±9c</td><td>21±1.2c</td></tr><tr><td>O. basilicum (10 mg/kg) + Iso</td><td>78±6</td><td>285±19</td><td>95±4</td><td>5.8±1.1***</td></tr><tr><td>O. basilicum (20 mg/kg) + Iso</td><td>90±11</td><td>294±21</td><td>109±10**</td><td>9.0±3.4***</td></tr><tr><td>O. basilicum (40 mg/kg) + Iso</td><td>113±4***</td><td>312±16</td><td>127±3***</td><td>6.6±1.5***</td></tr></table>
<table><tr><td>LV dP/dt/P (1/sec)</td></tr><tr><td></td></tr><tr><td>64±2.3</td></tr><tr><td>60±1.4</td></tr><tr><td>38±9.1b</td></tr><tr><td>69±4.5**</td></tr><tr><td>73±4.6***</td></tr><tr><td>95±2.8***</td></tr></table>
19b120f6774aa96ea3f820b3b8aeb691b1557d116f9c934ac4da225c67ef8558.png
complex
<table><tr><td> </td><td> </td><td colspan="3">Movements from</td><td colspan="3">Movements to</td></tr><tr><td> </td><td>N<sup>a</sup></td><td>Total</td><td>With haulier</td><td>%<sup>b</sup></td><td>Total</td><td>With haulier</td><td>%</td></tr><tr><td>Premises type</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Small-pig producer</td><td>1755</td><td>3888</td><td>108</td><td>3%</td><td>1927</td><td>211</td><td>11%</td></tr><tr><td>Non-assured commercial producers</td><td>285</td><td>6277</td><td>3550</td><td>57%</td><td>1232</td><td>798</td><td>65%</td></tr><tr><td>QHA producers</td><td>290</td><td>12237</td><td>9973</td><td>81%</td><td>4019</td><td>3601</td><td>90%</td></tr><tr><td>Slaughterhouse</td><td>29</td><td>2</td><td>0</td><td>0%</td><td>14105</td><td>8448</td><td>60%</td></tr><tr><td>Market</td><td>13</td><td>682</td><td>259</td><td>38%</td><td>1858</td><td>892</td><td>48%</td></tr><tr><td>Showground</td><td>8</td><td>20</td><td>0</td><td>0%</td><td>22</td><td>0</td><td>0%</td></tr><tr><td>Ferry collection centres</td><td>2</td><td>63</td><td>62</td><td>98%</td><td>6</td><td>2</td><td>33%</td></tr><tr><td>Scottish Regions</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Highlands and Islands</td><td>677</td><td>2690</td><td>821</td><td>31%</td><td>2058</td><td>274</td><td>13%</td></tr><tr><td>Mid Scotland and Fife</td><td>185</td><td>1464</td><td>562</td><td>38%</td><td>1311</td><td>166</td><td>13%</td></tr><tr><td>Scotland Central Belt</td><td>229</td><td>1994</td><td>901</td><td>45%</td><td>5134</td><td>3904</td><td>76%</td></tr><tr><td>South Scotland</td><td>428</td><td>3538</td><td>1810</td><td>51%</td><td>2337</td><td>841</td><td>36%</td></tr><tr><td>East Scotland</td><td>514</td><td>12872</td><td>9618</td><td>75%</td><td>8471</td><td>5639</td><td>67%</td></tr><tr><td>English Regions</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td>Yorkshire and The Humber</td><td>70</td><td>30</td><td>21</td><td>70%</td><td>371</td><td>351</td><td>95%</td></tr><tr><td>North East England</td><td>105</td><td>175</td><td>32</td><td>18%</td><td>1501</td><td>1362</td><td>91%</td></tr><tr><td>North West England</td><td>83</td><td>256</td><td>84</td><td>33%</td><td>660</td><td>470</td><td>71%</td></tr><tr><td>West Midlands</td><td>13</td><td>5</td><td>0</td><td>0%</td><td>31</td><td>22</td><td>71%</td></tr><tr><td>East Midlands</td><td>21</td><td>46</td><td>27</td><td>59%</td><td>685</td><td>458</td><td>67%</td></tr><tr><td>East of England</td><td>29</td><td>12</td><td>3</td><td>25%</td><td>585</td><td>460</td><td>79%</td></tr><tr><td>South East England</td><td>5</td><td>0</td><td>0</td><td>0%</td><td>7</td><td>1</td><td>0%</td></tr><tr><td>South West England</td><td>10</td><td>6</td><td>4</td><td>67%</td><td>7</td><td>2</td><td>29%</td></tr><tr><td>Northern Ireland</td><td>-</td><td>63</td><td>62</td><td>98%</td><td>6</td><td>2</td><td>33%</td></tr><tr><td>Wales</td><td>8</td><td>8</td><td>3</td><td>38%</td><td>4</td><td>0</td><td>0%</td></tr><tr><td>Other countries</td><td>-</td><td>10</td><td>4</td><td>40%</td><td>1</td><td>0</td><td>0%</td></tr></table>
<table><tr><td></td><td></td><td colspan="3">Movements from</td><td colspan="3">Movements to</td></tr><tr><td></td><td>Na</td><td>Total</td><td>With haulier</td><td>%b</td><td>Total</td><td>With haulier</td><td>%</td></tr></table>
<table><tr><td>Premises type</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Small-pig producer</td><td>1755</td><td>3888</td><td>108</td><td>3%</td><td>1927</td><td>211</td><td>11%</td></tr><tr><td>Non-assured commercial producers</td><td>285</td><td>6277</td><td>3550</td><td>57%</td><td>1232</td><td>798</td><td>65%</td></tr><tr><td>QHA producers</td><td>290</td><td>12237</td><td>9973</td><td>81%</td><td>4019</td><td>3601</td><td>90%</td></tr><tr><td>Slaughterhouse</td><td>29</td><td>2</td><td>0</td><td>0%</td><td>14105</td><td>8448</td><td>60%</td></tr><tr><td>Market</td><td>13</td><td>682</td><td>259</td><td>38%</td><td>1858</td><td>892</td><td>48%</td></tr><tr><td>Showground</td><td>8</td><td>20</td><td>0</td><td>0%</td><td>22</td><td>0</td><td>0%</td></tr><tr><td>Ferry collection centres</td><td>2</td><td>63</td><td>62</td><td>98%</td><td>6</td><td>2</td><td>33%</td></tr><tr><td>Scottish Regions</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Highlands and Islands</td><td>677</td><td>2690</td><td>821</td><td>31%</td><td>2058</td><td>274</td><td>13%</td></tr><tr><td>Mid Scotland and Fife</td><td>185</td><td>1464</td><td>562</td><td>38%</td><td>1311</td><td>166</td><td>13%</td></tr><tr><td>Scotland Central Belt</td><td>229</td><td>1994</td><td>901</td><td>45%</td><td>5134</td><td>3904</td><td>76%</td></tr><tr><td>South Scotland</td><td>428</td><td>3538</td><td>1810</td><td>51%</td><td>2337</td><td>841</td><td>36%</td></tr><tr><td>East Scotland</td><td>514</td><td>12872</td><td>9618</td><td>75%</td><td>8471</td><td>5639</td><td>67%</td></tr><tr><td>English Regions</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Yorkshire and The Humber</td><td>70</td><td>30</td><td>21</td><td>70%</td><td>371</td><td>351</td><td>95%</td></tr><tr><td>North East England</td><td>105</td><td>175</td><td>32</td><td>18%</td><td>1501</td><td>1362</td><td>91%</td></tr><tr><td>North West England</td><td>83</td><td>256</td><td>84</td><td>33%</td><td>660</td><td>470</td><td>71%</td></tr><tr><td>West Midlands</td><td>13</td><td>5</td><td>0</td><td>0%</td><td>31</td><td>22</td><td>71%</td></tr><tr><td>East Midlands</td><td>21</td><td>46</td><td>27</td><td>59%</td><td>685</td><td>458</td><td>67%</td></tr><tr><td>East of England</td><td>29</td><td>12</td><td>3</td><td>25%</td><td>585</td><td>460</td><td>79%</td></tr><tr><td>South East England</td><td>5</td><td>0</td><td>0</td><td>0%</td><td>7</td><td>1</td><td>0%</td></tr><tr><td>South West England</td><td>10</td><td>6</td><td>4</td><td>67%</td><td>7</td><td>2</td><td>29%</td></tr><tr><td>Northern Ireland</td><td>-</td><td>63</td><td>62</td><td>98%</td><td>6</td><td>2</td><td>33%</td></tr><tr><td>Wales</td><td>8</td><td>8</td><td>3</td><td>38%</td><td>4</td><td>0</td><td>0%</td></tr><tr><td>Other countries</td><td>-</td><td>10</td><td>4</td><td>40%</td><td>1</td><td>0</td><td>0%</td></tr></table>
30a4e4b69cdd831dbf3a94a565ad1bbdcabb4db4183dffc5a14210eaa99e5f20.png
simple
<table><tr><td>Strains</td><td>No. of plants inoculated</td><td>Infection rate (%)</td><td>Wilt index<sup>a</sup></td></tr><tr><td><i>Fusarium solani</i> CFD-1</td><td>160</td><td>96.3</td><td>3.6</td></tr><tr><td><i>Fusarium oxysporum</i> CFD-1</td><td>144</td><td>97.9</td><td>3.7</td></tr></table>
<table><tr><td>Strains</td><td>No. of plants inoculated</td><td>Infection rate (%)</td><td>Wilt indexa</td></tr><tr><td>Fusarium solani CFD-1</td><td>160</td><td>96.3</td><td>3.6</td></tr></table>
<table><tr><td>Fusarium oxysporum CFD-1</td><td>144</td><td>97.9</td><td>3.7</td></tr></table>
eea29d126add175bc0d334c4d54070d252bfea787d632d5a43f28ff76f4ec89e.png
simple
<table><tr><td>Covariate</td><td>Multivariate analysis hazard ratio</td><td>p value</td></tr><tr><td>Sex, male versus female</td><td>0.87 (0.23&#8211;3.29)</td><td>0.837</td></tr><tr><td>Age at revision</td><td>1.02 (0.96&#8211;1.08)</td><td>0.497</td></tr><tr><td>Body mass index</td><td>1.05 (0.93&#8211;1.18)</td><td>0.461</td></tr><tr><td>Revision indication</td><td></td><td></td></tr><tr><td> Pseudotumor versus</td><td>1.00</td><td>Baseline</td></tr><tr><td> Fracture</td><td>0.21 (0.31-1.40)</td><td>0.106</td></tr><tr><td> Other</td><td>0.31 (0.49&#8211;1.90)</td><td>0.203</td></tr><tr><td>Type of revision</td><td></td><td></td></tr><tr><td> Femoral only with metal-on-metal bearing versus all component revision with nonmetal-on-metal bearing</td><td>5.65 (1.08&#8211;29.4)</td><td>0.040</td></tr></table>
<table><tr><td>Covariate</td><td>Multivariate analysis hazard ratio</td><td>p value</td></tr><tr><td>Sex, male versus female</td><td>0.87 (0.23–3.29)</td><td>0.837</td></tr><tr><td>Age at revision</td><td>1.02 (0.96–1.08)</td><td>0.497</td></tr></table>
<table><tr><td>Covariate</td><td>Multivariate analysis hazard ratio</td><td>p value</td></tr><tr><td>Body mass index</td><td>1.05 (0.93–1.18)</td><td>0.461</td></tr><tr><td>Revision indication</td><td></td><td></td></tr><tr><td>Pseudotumor versus</td><td>1.00</td><td>Baseline</td></tr><tr><td>Fracture</td><td>0.21 (0.31-1.40)</td><td>0.106</td></tr><tr><td>Other</td><td>0.31 (0.49–1.90)</td><td>0.203</td></tr><tr><td>Type of revision</td><td></td><td></td></tr><tr><td>Femoral only with metal-on-metal bearing versus all component revision with nonmetal-on-metal bearing</td><td>5.65 (1.08–29.4)</td><td>0.040</td></tr></table>
be6786e6117ba6297d43990ca277c28c15dddcd6b525b5c251f41c0979896193.png
complex
<table><tr><td rowspan="2">Variable</td><td>Sulpiride</td><td>Placebo</td><td><i>p</i>-value</td></tr><tr><td>Mean (SD)</td><td>Mean (SD)</td><td></td></tr><tr><td colspan="4">Participant characteristics</td></tr><tr><td> Age (years)</td><td>24.58 (4.19)</td><td>23.92 (4.70)</td><td>0.717</td></tr><tr><td> Body mass index (kg/m<sup>2</sup>)</td><td>24.56 (1.45)</td><td>24.32 (3.57)</td><td>0.832</td></tr><tr><td> Education (years)</td><td>15.92 (1.45)</td><td>14.92 (2.78)</td><td>0.289</td></tr><tr><td> Raven&#8217;s matrices (percentile)</td><td>88.00 (16.69)</td><td>86.08 (15.68)</td><td>0.774</td></tr></table>
<table><tr><td rowspan="2">Variable</td><td>Sulpiride</td><td>Placebo</td></tr><tr><td>Mean (SD)</td><td>Mean (SD)</td></tr><tr><td colspan="3">Participant characteristics</td></tr><tr><td>Age (years)</td><td>24.58 (4.19)</td><td>23.92 (4.70)</td></tr><tr><td>Body mass index (kg/m2)</td><td>24.56 (1.45)</td><td>24.32 (3.57)</td></tr><tr><td>Education (years)</td><td>15.92 (1.45)</td><td>14.92 (2.78)</td></tr><tr><td>Raven’s matrices (percentile)</td><td>88.00 (16.69)</td><td>86.08 (15.68)</td></tr></table>
<table><tr><td>p-value</td></tr><tr><td></td></tr><tr><td>Participant characteristics</td></tr><tr><td>0.717</td></tr><tr><td>0.832</td></tr><tr><td>0.289</td></tr><tr><td>0.774</td></tr></table>
d863cb8ab1f12e43decd1cbd819abbd3be0459dd97f82018ad1e295fefd440de.png
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<table><tr><td></td><td>Total (<i>N</i> = 2,716)</td><td>CDSMP non-completion (<i>N</i> = 557)</td><td colspan="2">CDSMP completion (<i>N</i> = 2,159)</td></tr><tr><td></td><td><i>N</i> (%)</td><td><i>N</i> (%)</td><td><i>N</i> (%)</td><td><i>P-</i>value*</td></tr><tr><td>Female</td><td>1,985 (73.1)</td><td>397 (71.3)</td><td>1, 588 (73.6)</td><td>0.280</td></tr><tr><td>Living alone</td><td>68 (2.5)</td><td>19 (3.4)</td><td>49 (2.3)</td><td>0.124</td></tr><tr><td>Rural&#8211;urban commuting area codes</td><td></td><td></td><td></td><td>0.009</td></tr><tr><td> Metro</td><td>2,479 (91.3)</td><td>524 (94.1)</td><td>1, 955 (90.6)</td><td></td></tr><tr><td> Non-metro</td><td>237 (8.7)</td><td>33 (5.9)</td><td>204 (9.5)</td><td></td></tr><tr><td>Workshop delivery site</td><td></td><td></td><td></td><td>0.010</td></tr><tr><td> Other</td><td>341 (12.6)</td><td>77 (13.8)</td><td>264 (12.2)</td><td></td></tr><tr><td> Area agency on aging/senior centers</td><td>741 (27.3)</td><td>123 (22.1)</td><td>618 (28.6)</td><td></td></tr><tr><td> Health care organization</td><td>379 (14.0)</td><td>77 (13.8)</td><td>302 (14.0)</td><td></td></tr><tr><td> Residential facilities</td><td>431 (15.9)</td><td>111 (19.9)</td><td>320 (14.8)</td><td></td></tr><tr><td> Community/multi-purpose</td><td>720 (26.5)</td><td>148 (26.6)</td><td>572 (26.5)</td><td></td></tr><tr><td> Faith-based organization</td><td>104 (3.8)</td><td>21 (3.8)</td><td>83 (3.8)</td><td></td></tr><tr><td></td><td>Mean (&#177;SD)</td><td>Mean (&#177;SD)</td><td>Mean (&#177;SD)</td><td><i>P</i>-value<sup>a</sup></td></tr><tr><td>Age in years (from 50 to 101)</td><td>71.3 (&#177;9.2)</td><td>71.2 (&#177;9.5)</td><td>71.4 (&#177; 9.2)</td><td>0.670</td></tr><tr><td>Neighborhood median income in $10,000 unit (from 2.2 to 11.6)</td><td>6.2 (&#177;1.4)</td><td>6.2 (&#177;1.5)</td><td>6.2 (&#177; 1.3)</td><td>0.466</td></tr><tr><td>Number of chronic conditions (from 0 to 10)</td><td>2.0 (&#177;1.5)</td><td>1.9 (&#177;1.4)</td><td>2.1 (&#177; 1.5)</td><td>0.009</td></tr><tr><td>% Of Asian-Americans in the workshop</td><td>57.5 (&#177;36.8)</td><td>53.2 (&#177;36.7)</td><td>58.6 (&#177; 36.7)</td><td>0.002</td></tr><tr><td>Workshop completion rate (%)</td><td>74.9 (&#177;18.7)</td><td>66.4 (&#177;18.7)</td><td>77.1 (&#177; 18.0)</td><td>&lt;0.001</td></tr></table>
<table><tr><td></td><td>Total (N = 2,716)</td><td>CDSMP non-completion (N = 557)</td><td colspan="2">CDSMP completion (N = 2,159)</td></tr><tr><td></td><td>N (%)</td><td>N (%)</td><td>N (%)</td><td>P-value*</td></tr><tr><td>Female</td><td>1,985 (73.1)</td><td>397 (71.3)</td><td>1, 588 (73.6)</td><td>0.280</td></tr><tr><td>Living alone</td><td>68 (2.5)</td><td>19 (3.4)</td><td>49 (2.3)</td><td>0.124</td></tr><tr><td>Rural–urban commut</td><td></td><td></td><td></td><td>0.009</td></tr></table>
<table><tr><td>ing area codes</td><td></td><td></td><td></td><td></td></tr><tr><td>Metro</td><td>2,479 (91.3)</td><td>524 (94.1)</td><td>1, 955 (90.6)</td><td></td></tr><tr><td>Non-metro</td><td>237 (8.7)</td><td>33 (5.9)</td><td>204 (9.5)</td><td></td></tr><tr><td>Workshop delivery site</td><td></td><td></td><td></td><td>0.010</td></tr><tr><td>Other</td><td>341 (12.6)</td><td>77 (13.8)</td><td>264 (12.2)</td><td></td></tr><tr><td>Area agency on aging/senior centers</td><td>741 (27.3)</td><td>123 (22.1)</td><td>618 (28.6)</td><td></td></tr><tr><td>Health care organization</td><td>379 (14.0)</td><td>77 (13.8)</td><td>302 (14.0)</td><td></td></tr><tr><td>Residential facilities</td><td>431 (15.9)</td><td>111 (19.9)</td><td>320 (14.8)</td><td></td></tr><tr><td>Community/multi-purpose</td><td>720 (26.5)</td><td>148 (26.6)</td><td>572 (26.5)</td><td></td></tr><tr><td>Faith-based organization</td><td>104 (3.8)</td><td>21 (3.8)</td><td>83 (3.8)</td><td></td></tr><tr><td></td><td>Mean (±SD)</td><td>Mean (±SD)</td><td>Mean (±SD)</td><td>P-valuea</td></tr><tr><td>Age in years (from 50 to 101)</td><td>71.3 (±9.2)</td><td>71.2 (±9.5)</td><td>71.4 (± 9.2)</td><td>0.670</td></tr><tr><td>Neighborhood median income in $10,000 unit (from 2.2 to 11.6)</td><td>6.2 (±1.4)</td><td>6.2 (±1.5)</td><td>6.2 (± 1.3)</td><td>0.466</td></tr><tr><td>Number of chronic conditions (from 0 to 10)</td><td>2.0 (±1.5)</td><td>1.9 (±1.4)</td><td>2.1 (± 1.5)</td><td>0.009</td></tr><tr><td>% Of Asian-Americans in the workshop</td><td>57.5 (±36.8)</td><td>53.2 (±36.7)</td><td>58.6 (± 36.7)</td><td>0.002</td></tr><tr><td>Workshop completion rate (%)</td><td>74.9 (±18.7)</td><td>66.4 (±18.7)</td><td>77.1 (± 18.0)</td><td><0.001</td></tr></table>
6273d536533b03537f49ed71978d6e41874f2f6b17688993ecfd5a0a7a9c1130.png
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<table><tr><td></td><td>Renal failure (<i>n</i> = 30)</td><td>Matched controls (<i>n</i> = 30)</td><td><i>p</i>-Value</td></tr><tr><td>Liver SUVmax</td><td>2.90 (1.60&#8211;3.90)</td><td>2.60 (1.80&#8211;3.90)</td><td>0.62</td></tr><tr><td>Psoas muscle SUVmax</td><td>1.30 (1.10&#8211;2.50)</td><td>1.35 (0.90&#8211;2.80)</td><td>0.57</td></tr></table>
<table><tr><td></td><td>Renal failure (n = 30)</td><td>Matched controls (n = 30)</td><td>p-Value</td></tr></table>
<table><tr><td>Liver SUVmax</td><td>2.90 (1.60–3.90)</td><td>2.60 (1.80–3.90)</td><td>0.62</td></tr><tr><td>Psoas muscle SUVmax</td><td>1.30 (1.10–2.50)</td><td>1.35 (0.90–2.80)</td><td>0.57</td></tr></table>
1aba8fc9ad9ad7c53803d4ec53cb736377824f66ff11600d33d8bb0e15e7cca4.png
complex
<table><tr><td></td><td colspan="2">Control Group Individuals (n = 32)</td><td colspan="2">Intervention Group Individuals (n = 37)</td><td colspan="2">Unadjustedsignificance</td><td colspan="2">Adjusted for highest qualification at baseline</td></tr><tr><td>Individual Domain</td><td>Mean baseline</td><td>Mean follow-up</td><td>Mean baseline</td><td>Meanfollow-up</td><td>Coefficient</td><td>P value</td><td>Coefficient</td><td>P value</td></tr><tr><td>i) Finding relevant literature</td><td>6.42</td><td>6.89</td><td>6.00</td><td>7.59</td><td>0.72</td><td>0.16</td><td>0.87</td><td>0.10</td></tr><tr><td>ii) Critically reviewing the literature</td><td>6.03</td><td>6.72</td><td>5.78</td><td>6.69</td><td>-0.33</td><td>0.95</td><td>0.25</td><td>0.61</td></tr><tr><td>iii) Using a computer referencing system (eg Endnote)</td><td>4.52</td><td>5.22</td><td>3.47</td><td>4.71</td><td>0.59</td><td>0.38</td><td>0.54</td><td>0.43</td></tr><tr><td>iv) Writing a research protocol</td><td>4.06</td><td>4.39</td><td>3.67</td><td>5.69</td><td>1.42</td><td>&lt; 0.05*</td><td>1.76</td><td>&lt; 0.05*</td></tr><tr><td>v) Securing research funding</td><td>2.90</td><td>3.29</td><td>2.75</td><td>4.70</td><td>1.53</td><td>&lt; 0.05*</td><td>1.46</td><td>&lt; 0.05*</td></tr><tr><td>vi) Submitting an ethics application</td><td>3.48</td><td>3.47</td><td>3.58</td><td>6.10</td><td>2.38</td><td>&lt; 0.001**</td><td>2.37</td><td>&lt; 0.001**</td></tr><tr><td>vii) Designing questionnaires</td><td>5.00</td><td>5.67</td><td>4.39</td><td>5.96</td><td>0.61</td><td>0.38</td><td>0.86</td><td>0.23</td></tr><tr><td>viii) Collecting data e.g. surveys, interviews</td><td>5.58</td><td>6.72</td><td>5.53</td><td>7.00</td><td>0.22</td><td>0.76</td><td>0.42</td><td>0.57</td></tr><tr><td>ix) Using computer data management systems</td><td>4.16</td><td>5.22</td><td>3.71</td><td>4.68</td><td>-0.39</td><td>0.93</td><td>0.11</td><td>0.81</td></tr><tr><td>x) Analysing qualitative research data</td><td>4.39</td><td>5.47</td><td>2.97</td><td>5.10</td><td>1.14</td><td>&lt; 0.1<sup>&#8224;</sup></td><td>1.27</td><td>&lt; 0.05*</td></tr><tr><td>xi) Analysing quantitative research data</td><td>3.94</td><td>5.17</td><td>3.67</td><td>4.39</td><td>-0.54</td><td>0.38</td><td>-0.40</td><td>0.53</td></tr><tr><td>xii) Writing a research report</td><td>4.45</td><td>4.39</td><td>4.00</td><td>5.18</td><td>0.96</td><td>&lt; 0.1<sup>&#8224;</sup></td><td>1.28</td><td>&lt; 0.05*</td></tr><tr><td>xiii) Writing for publication in peer-reviewed journals</td><td>3.81</td><td>4.00</td><td>3.14</td><td>4.80</td><td>1.15</td><td>&lt; .0.05*</td><td>1.04</td><td>&lt; 0.1<sup>&#8224;</sup></td></tr><tr><td>xiv) Integrating research findings into practice</td><td>6.34</td><td>7.11</td><td>6.28</td><td>6.76</td><td>-0.27</td><td>0.67</td><td>-0.18</td><td>0.79</td></tr><tr><td>xv) Providing advice to less experienced researchers</td><td>6.67</td><td>3.76</td><td>3.00</td><td>4.93</td><td>1.22</td><td>&lt; 0.05*</td><td>1.23</td><td>&lt; 0.05*</td></tr><tr><td>Total score</td><td>4.65</td><td>5.19</td><td>4.13</td><td>5.63</td><td>0.98</td><td>&lt; 0.05*</td><td>1.11</td><td>&lt; 0.05*</td></tr></table>
<table><tr><td></td><td colspan="2">Control Group Individuals (n = 32)</td><td colspan="2">Intervention Group Individuals (n = 37)</td><td colspan="2">Unadjustedsignificance</td><td colspan="2">Adjusted for highest qualification at baseline</td></tr><tr><td>Individual Domain</td><td>Mean baseline</td><td>Mean follow-up</td><td>Mean baseline</td><td>Meanfollow-up</td><td>Coefficient</td><td>P value</td><td>Coefficient</td><td>P value</td></tr><tr><td>i) Finding relevant literature</td><td>6.42</td><td>6.89</td><td>6.00</td><td>7.59</td><td>0.72</td><td>0.16</td><td>0.87</td><td>0.10</td></tr><tr><td>ii) Critically reviewing the literature</td><td>6.03</td><td>6.72</td><td>5.78</td><td>6.69</td><td>-0.33</td><td>0.95</td><td>0.25</td><td>0.61</td></tr></table>
<table><tr><td></td><td colspan="2">Control Group Individuals (n = 32)</td><td colspan="2">Intervention Group Individuals (n = 37)</td><td colspan="2">Unadjustedsignificance</td><td colspan="2">Adjusted for highest qualification at baseline</td></tr><tr><td>iii) Using a computer referencing system (eg Endnote)</td><td>4.52</td><td>5.22</td><td>3.47</td><td>4.71</td><td>0.59</td><td>0.38</td><td>0.54</td><td>0.43</td></tr><tr><td>iv) Writing a research protocol</td><td>4.06</td><td>4.39</td><td>3.67</td><td>5.69</td><td>1.42</td><td>< 0.05*</td><td>1.76</td><td>< 0.05*</td></tr><tr><td>v) Securing research funding</td><td>2.90</td><td>3.29</td><td>2.75</td><td>4.70</td><td>1.53</td><td>< 0.05*</td><td>1.46</td><td>< 0.05*</td></tr><tr><td>vi) Submitting an ethics application</td><td>3.48</td><td>3.47</td><td>3.58</td><td>6.10</td><td>2.38</td><td>< 0.001**</td><td>2.37</td><td>< 0.001**</td></tr><tr><td>vii) Designing questionnaires</td><td>5.00</td><td>5.67</td><td>4.39</td><td>5.96</td><td>0.61</td><td>0.38</td><td>0.86</td><td>0.23</td></tr><tr><td>viii) Collecting data e.g. surveys, interviews</td><td>5.58</td><td>6.72</td><td>5.53</td><td>7.00</td><td>0.22</td><td>0.76</td><td>0.42</td><td>0.57</td></tr><tr><td>ix) Using computer data management systems</td><td>4.16</td><td>5.22</td><td>3.71</td><td>4.68</td><td>-0.39</td><td>0.93</td><td>0.11</td><td>0.81</td></tr><tr><td>x) Analysing qualitative research data</td><td>4.39</td><td>5.47</td><td>2.97</td><td>5.10</td><td>1.14</td><td>< 0.1†</td><td>1.27</td><td>< 0.05*</td></tr><tr><td>xi) Analysing quantitative research data</td><td>3.94</td><td>5.17</td><td>3.67</td><td>4.39</td><td>-0.54</td><td>0.38</td><td>-0.40</td><td>0.53</td></tr><tr><td>xii) Writing a research report</td><td>4.45</td><td>4.39</td><td>4.00</td><td>5.18</td><td>0.96</td><td>< 0.1†</td><td>1.28</td><td>< 0.05*</td></tr><tr><td>xiii) Writing for publication in peer-reviewed journals</td><td>3.81</td><td>4.00</td><td>3.14</td><td>4.80</td><td>1.15</td><td>< .0.05*</td><td>1.04</td><td>< 0.1†</td></tr><tr><td>xiv) Integrating research findings into practice</td><td>6.34</td><td>7.11</td><td>6.28</td><td>6.76</td><td>-0.27</td><td>0.67</td><td>-0.18</td><td>0.79</td></tr><tr><td>xv) Providing advice to less experienced researchers</td><td>6.67</td><td>3.76</td><td>3.00</td><td>4.93</td><td>1.22</td><td>< 0.05*</td><td>1.23</td><td>< 0.05*</td></tr><tr><td>Total score</td><td>4.65</td><td>5.19</td><td>4.13</td><td>5.63</td><td>0.98</td><td>< 0.05*</td><td>1.11</td><td>< 0.05*</td></tr></table>
2fa3ea6aef0fdbb010c3e60141a2ccbceaafed23cc7a52419ae9dee61f0f2457.png
complex
<table><tr><td rowspan="2">Frequency</td><td colspan="2">Detected rate (n (%))</td><td></td><td colspan="3">Amplitude (dB SPL)</td><td colspan="3">S/N (dB)</td></tr><tr><td>TTH</td><td>Control</td><td><i>P</i>-value</td><td>TTH</td><td>Control</td><td><i>P</i>-value</td><td>TTH</td><td>Control</td><td><i>P</i>-value</td></tr><tr><td>Overall echo level</td><td>45 (97.8)</td><td>51 (98.1)</td><td>0.930</td><td>12.7 &#177; 4.1</td><td>12.5 &#177; 3.5</td><td><i>0.796</i></td><td>16.6 &#177; 4.6</td><td>14.9 &#177; 4.9</td><td><i>0.059</i></td></tr><tr><td>0.5-1 kHz</td><td>45 (97.8)</td><td>51 (98.1)</td><td>0.930</td><td>11.2 &#177; 4.3</td><td>10.4 &#177; 3.7</td><td><i>0.339</i></td><td>17.2 &#177; 5.8</td><td>14.5 &#177; 5.1</td><td><i>0.015</i></td></tr><tr><td>1-2 kHz</td><td>46 (100)</td><td>52 (100)</td><td>-</td><td>5.3 &#177; 5.9</td><td>7.0 &#177; 4.8</td><td><i>0.135</i></td><td>16.9 &#177; 5.7</td><td>17.2 &#177; 5.3</td><td><i>0.792</i></td></tr><tr><td>2-4 kHz</td><td>17 (37.0)</td><td>15 (28.8)</td><td>0.393</td><td>&#8722;9.5 &#177; 4.6</td><td>&#8722;10.1 &#177; 3.3</td><td><i>0.437</i></td><td>3.1 &#177; 5.0</td><td>2.7 &#177; 3.7</td><td><i>0.621</i></td></tr></table>
<table><tr><td rowspan="2">Frequency</td><td colspan="2">Detected rate (n (%))</td><td></td><td colspan="3">Amplitude (dB SPL)</td><td colspan="3">S/N (dB)</td></tr><tr><td>TTH</td><td>Control</td><td>P-value</td><td>TTH</td><td>Control</td><td>P-value</td><td>TTH</td><td>Control</td><td>P-value</td></tr><tr><td>Overall echo level</td><td>45 (97.8)</td><td>51 (98.1)</td><td>0.930</td><td>12.7 ± 4.1</td><td>12.5 ± 3.5</td><td>0.796</td><td>16.6 ± 4.6</td><td>14.9 ± 4.9</td><td>0.059</td></tr></table>
<table><tr><td>0.5-1 kHz</td><td>45 (97.8)</td><td>51 (98.1)</td><td>0.930</td><td>11.2 ± 4.3</td><td>10.4 ± 3.7</td><td>0.339</td><td>17.2 ± 5.8</td><td>14.5 ± 5.1</td><td>0.015</td></tr><tr><td>1-2 kHz</td><td>46 (100)</td><td>52 (100)</td><td>-</td><td>5.3 ± 5.9</td><td>7.0 ± 4.8</td><td>0.135</td><td>16.9 ± 5.7</td><td>17.2 ± 5.3</td><td>0.792</td></tr><tr><td>2-4 kHz</td><td>17 (37.0)</td><td>15 (28.8)</td><td>0.393</td><td>−9.5 ± 4.6</td><td>−10.1 ± 3.3</td><td>0.437</td><td>3.1 ± 5.0</td><td>2.7 ± 3.7</td><td>0.621</td></tr></table>
66efd0575799e5a4c604928ea4eb8489a0baacb7448b1afcbf3727b02257131e.png
simple
<table><tr><td> </td><td>Non-diabetes HbA1c &lt;5.7%n = 380</td><td>Pre-diabetes HbA1c &#8805;5.7%n = 259</td><td>Diabetes<sup>a</sup>n = 84</td><td><i>P</i><sup>b</sup></td></tr><tr><td>Total FAs (mg/L)</td><td>3,790 (3,680 to 3,900)<sup>c</sup></td><td>3,680 (3,560 to 3,810)</td><td>4,050 (3,820 to 4,300)</td><td>0.02</td></tr><tr><td>Saturated FAs</td><td>33.2 (32.9 to 33.4)</td><td>33.2 (32.9 to 33.5)</td><td>34.0 (33.5 to 34.5)</td><td>0.01</td></tr><tr><td>Monounsaturated FAs</td><td>22.9 (22.5 to 23.2)</td><td>23.2 (22.7 to 23.6)</td><td>24.0 (23.2 to 24.8)</td><td>0.03</td></tr><tr><td>n-6 PUFAs</td><td>35.0 (34.4 to 35.5)</td><td>34.5 (33.9 to 35.2)</td><td>32.8 (31.8 to 33.9)</td><td>0.002</td></tr><tr><td>n-3 PUFAs</td><td>7.2 (7.0 to 7.5)</td><td>7.4 (7.1 to 7.8)</td><td>7.2 (6.6 to 7.8)</td><td>0.61</td></tr><tr><td>&#945;-Linolenic acid</td><td>0.71 (0.69 to 0.73)</td><td>0.73 (0.70 to 0.75)</td><td>0.72 (0.68 to 0.77)</td><td>0.38</td></tr><tr><td>Eicosapentaenoic acid</td><td>1.80 (1.68 to 1.92)</td><td>1.91 (1.76 to 2.07)</td><td>1.78 (1.54 to 2.05)</td><td>0.49</td></tr><tr><td>Docosapentaenoic acid (n-3)</td><td>0.62 (0.60 to 0.63)</td><td>0.63 (0.61 to 0.65)</td><td>0.62 (0.58 to 0.65)</td><td>0.55</td></tr><tr><td>Docosahexaenoic acid</td><td>3.69 (3.56 to 3.82)</td><td>3.73 (3.58 to 3.90)</td><td>3.63 (3.37 to 3.91)</td><td>0.79</td></tr><tr><td>n-3 PUFA / n-6 PUFA ratio</td><td>0.21 (0.20 to 0.22)</td><td>0.22 (0.20 to 0.23)</td><td>0.22 (0.20 to 0.24)</td><td>0.41</td></tr></table>
<table><tr><td></td><td>Non-diabetes HbA1c <5.7%n = 380</td><td>Pre-diabetes HbA1c ≥5.7%n = 259</td><td>Diabetesan = 84</td><td>Pb</td></tr><tr><td>Total FAs (mg/L)</td><td>3,790 (3,680 to 3,900)c</td><td>3,680 (3,560 to 3,810)</td><td>4,050 (3,820 to 4,300)</td><td>0.02</td></tr></table>
<table><tr><td></td><td>Non-diabetes HbA1c <5.7%n = 380</td><td>Pre-diabetes HbA1c ≥5.7%n = 259</td><td>Diabetesan = 84</td><td>Pb</td></tr><tr><td>Saturated FAs</td><td>33.2 (32.9 to 33.4)</td><td>33.2 (32.9 to 33.5)</td><td>34.0 (33.5 to 34.5)</td><td>0.01</td></tr><tr><td>Monounsaturated FAs</td><td>22.9 (22.5 to 23.2)</td><td>23.2 (22.7 to 23.6)</td><td>24.0 (23.2 to 24.8)</td><td>0.03</td></tr><tr><td>n-6 PUFAs</td><td>35.0 (34.4 to 35.5)</td><td>34.5 (33.9 to 35.2)</td><td>32.8 (31.8 to 33.9)</td><td>0.002</td></tr><tr><td>n-3 PUFAs</td><td>7.2 (7.0 to 7.5)</td><td>7.4 (7.1 to 7.8)</td><td>7.2 (6.6 to 7.8)</td><td>0.61</td></tr><tr><td>α-Linolenic acid</td><td>0.71 (0.69 to 0.73)</td><td>0.73 (0.70 to 0.75)</td><td>0.72 (0.68 to 0.77)</td><td>0.38</td></tr><tr><td>Eicosapentaenoic acid</td><td>1.80 (1.68 to 1.92)</td><td>1.91 (1.76 to 2.07)</td><td>1.78 (1.54 to 2.05)</td><td>0.49</td></tr><tr><td>Docosapentaenoic acid (n-3)</td><td>0.62 (0.60 to 0.63)</td><td>0.63 (0.61 to 0.65)</td><td>0.62 (0.58 to 0.65)</td><td>0.55</td></tr><tr><td>Docosahexaenoic acid</td><td>3.69 (3.56 to 3.82)</td><td>3.73 (3.58 to 3.90)</td><td>3.63 (3.37 to 3.91)</td><td>0.79</td></tr><tr><td>n-3 PUFA / n-6 PUFA ratio</td><td>0.21 (0.20 to 0.22)</td><td>0.22 (0.20 to 0.23)</td><td>0.22 (0.20 to 0.24)</td><td>0.41</td></tr></table>
5f5e635d2bf18706febf07006c6d107bb7788520ef6b578e6d02588c8438ca07.png
simple
<table><tr><td>Characteristics</td><td>Number (n)</td><td>*Percent (%)</td></tr><tr><td><i>Age group of women (years)</i></td><td></td><td></td></tr><tr><td>15-19</td><td>1933</td><td>17.5</td></tr><tr><td>20-29</td><td>6770</td><td>61.3</td></tr><tr><td>30-49</td><td>2336</td><td>21.2</td></tr><tr><td>Missing</td><td>[141]</td><td></td></tr><tr><td><i>Parity</i></td><td></td><td></td></tr><tr><td>0</td><td>3811</td><td>35.7</td></tr><tr><td>1</td><td>2155</td><td>20.2</td></tr><tr><td>2-4</td><td>3210</td><td>30.1</td></tr><tr><td>&#8805;5</td><td>1492</td><td>14.0</td></tr><tr><td>Missing</td><td>[512]</td><td></td></tr><tr><td><i>Singleton/Multiple</i></td><td></td><td></td></tr><tr><td>Singleton</td><td>9696</td><td>95.6</td></tr><tr><td>Multiple</td><td>451</td><td>4.4</td></tr><tr><td>Missing</td><td>[1033]</td><td></td></tr><tr><td><i>Occupation of mother </i></td><td></td><td></td></tr><tr><td>Salaried employee/business</td><td>1062</td><td>20.6</td></tr><tr><td>Subsistence farmer</td><td>1215</td><td>23.5</td></tr><tr><td>Housewife</td><td>2886</td><td>55.9</td></tr><tr><td>Missing</td><td>[6017]</td><td></td></tr><tr><td>Mbarara</td><td>3916</td><td>35.0</td></tr><tr><td>Bushenyi</td><td>3510</td><td>31.4</td></tr><tr><td>Ibanda</td><td>1045</td><td>9.3</td></tr><tr><td>Isingiro</td><td>936</td><td>8.4</td></tr><tr><td>Kiruhura</td><td>905</td><td>8.1</td></tr><tr><td>Other districts</td><td>868</td><td>7.8</td></tr><tr><td><i>Name of health facility attended</i></td><td></td><td></td></tr><tr><td>Comboni hospital</td><td>636</td><td>5.7</td></tr><tr><td>Ibanda hospital</td><td>1803</td><td>16.1</td></tr><tr><td>Ishaka Adventist hospital</td><td>1435</td><td>12.8</td></tr><tr><td>Kitagata hospital</td><td>1098</td><td>9.8</td></tr><tr><td>Mbarara regional referral hospital</td><td>5731</td><td>51.3</td></tr><tr><td>Rushere Community hospital</td><td>477</td><td>4.3</td></tr></table>
<table><tr><td>Characteristics</td><td>Number (n)</td><td>*Percent (%)</td></tr><tr><td>Age group of women (years)</td><td></td><td></td></tr><tr><td>15-19</td><td>1933</td><td>17.5</td></tr><tr><td>20-29</td><td>6770</td><td>61.3</td></tr><tr><td>30-49</td><td>2336</td><td>21.2</td></tr><tr><td>Missing</td><td>[141]</td><td></td></tr><tr><td>Parity</td><td></td><td></td></tr><tr><td>0</td><td>3811</td><td>35.7</td></tr><tr><td>1</td><td>2155</td><td>20.2</td></tr><tr><td>2-4</td><td>3210</td><td>30.1</td></tr><tr><td>≥5</td><td>1492</td><td>14.0</td></tr><tr><td>Missing</td><td>[512]</td><td></td></tr><tr><td>Singleton/Multiple</td><td></td><td></td></tr><tr><td>Singleton</td><td>9696</td><td>95.6</td></tr><tr><td>Multiple</td><td>451</td><td>4.4</td></tr><tr><td>Missing</td><td>[1033]</td><td></td></tr><tr><td>Occupation of mother</td><td></td><td></td></tr><tr><td>Salaried employee/business</td><td>1062</td><td>20.6</td></tr><tr><td>Subsistence farmer</td><td>1215</td><td>23.5</td></tr><tr><td>Housewife</td><td>2886</td><td>55.9</td></tr><tr><td>Missing</td><td>[6017]</td><td></td></tr><tr><td>Mbarara</td><td>3916</td><td>35.0</td></tr><tr><td>Bushenyi</td><td>3510</td><td>31.4</td></tr><tr><td>Ibanda</td><td>1045</td><td>9.3</td></tr><tr><td>Isingiro</td><td>936</td><td>8.4</td></tr><tr><td>Kiruhura</td><td>905</td><td>8.1</td></tr><tr><td>Other districts</td><td>868</td><td>7.8</td></tr><tr><td>Name of health facility attended</td><td></td><td></td></tr><tr><td>Comboni hospital</td><td>636</td><td>5.7</td></tr></table>
<table><tr><td>Characteristics</td><td>Number (n)</td><td>*Percent (%)</td></tr><tr><td>Ibanda hospital</td><td>1803</td><td>16.1</td></tr><tr><td>Ishaka Adventist hospital</td><td>1435</td><td>12.8</td></tr><tr><td>Kitagata hospital</td><td>1098</td><td>9.8</td></tr><tr><td>Mbarara regional referral hospital</td><td>5731</td><td>51.3</td></tr><tr><td>Rushere Community hospital</td><td>477</td><td>4.3</td></tr></table>
57955678f1f81a7f18e8ad3abd3d76d579cc3ae3803a4850674f8ca4bf4b5749.png
simple
<table><tr><td></td><td>Structured Care (31) </td><td>Care-As-Usual (11) </td><td><i>P </i>-value </td></tr><tr><td>Yearly check performed by (%)</td><td></td><td></td><td></td></tr><tr><td> General practitioner</td><td>29.0</td><td>36.4</td><td>0.65</td></tr><tr><td> Practice nurse</td><td>51.6</td><td>63.6</td><td>0.49</td></tr><tr><td> Practice assistant</td><td>6.5</td><td>0</td><td>0.39</td></tr><tr><td> Diabetes specialist nurse</td><td>3.2</td><td>0</td><td>0.55</td></tr><tr><td> GP with PN/PA</td><td>9.7</td><td>0</td><td>0.28</td></tr><tr><td>Tri-monthly checks performed by (%)</td><td></td><td></td><td></td></tr><tr><td> General practitioner</td><td>16.1</td><td>9.1</td><td>0.57</td></tr><tr><td> Practice nurse</td><td>61.6</td><td>63.6</td><td>0.89</td></tr><tr><td> Practice assistant</td><td>22.6</td><td>27.3</td><td>0.75</td></tr><tr><td>Insulin treatments provided by (%)</td><td></td><td></td><td></td></tr><tr><td> Internist</td><td>6.5**</td><td>63.6**</td><td>&lt;0.001</td></tr><tr><td> General practitioner</td><td>61.3</td><td>36.4</td><td>0.15</td></tr><tr><td> Practice nurse</td><td>16.1</td><td>18.2</td><td>0.88</td></tr><tr><td> Diabetes specialist nurse</td><td>67.7**</td><td>18.2**</td><td>0.005</td></tr><tr><td>Consultation between healthcare professionals (%)</td><td></td><td></td><td></td></tr><tr><td> General practitioner</td><td>100*</td><td>80.0*</td><td>0.02</td></tr><tr><td> Practice nurse</td><td>71.4</td><td>70.0</td><td>0.93</td></tr><tr><td> Practice assistant</td><td>46.4</td><td>40.0</td><td>0.73</td></tr><tr><td> Diabetes specialist nurse</td><td>78.6**</td><td>30.0**</td><td>0.005</td></tr><tr><td> Dietician</td><td>50.0*</td><td>10.0*</td><td>0.03</td></tr><tr><td>Estimated percentage of patients that received education</td><td></td><td></td><td></td></tr><tr><td> Diet % (sd)</td><td>86.7 (17.9)</td><td>83.5 (28.7)</td><td>0.91</td></tr><tr><td> Exercise % (sd)</td><td>89.6 (16.0)</td><td>76.0 (29.5)</td><td>0.17</td></tr><tr><td> Smoking behavior % (sd)</td><td>90.0 (11.4)</td><td>73.3 (44.2)</td><td>0.17</td></tr><tr><td> Foot examination % (sd)</td><td>89.3 (17.0)</td><td>69.5 (38.3)</td><td>0.14</td></tr><tr><td>Education on diet, exercise, foot examination or smoking behavior.</td><td></td><td></td><td></td></tr><tr><td> by DSN (%)</td><td>35.0*</td><td>0.0*</td><td>0.04</td></tr><tr><td> by GP (%)</td><td>61.3</td><td>81.8</td><td>0.24</td></tr><tr><td> by PN/PA (%)</td><td>87.1</td><td>90.0</td><td>0.74</td></tr><tr><td>Diabetes passport, often or always used in practice (%)</td><td>78.6*</td><td>40.0*</td><td>0.05</td></tr></table>
<table><tr><td></td><td>Structured Care (31)</td><td>Care-As-Usual (11)</td><td>P -value</td></tr><tr><td>Yearly check performed by (%)</td><td></td><td></td><td></td></tr><tr><td>General practitioner</td><td>29.0</td><td>36.4</td><td>0.65</td></tr><tr><td>Practice nurse</td><td>51.6</td><td>63.6</td><td>0.49</td></tr><tr><td>Practice assistant</td><td>6.5</td><td>0</td><td>0.39</td></tr><tr><td>Diabetes specialist nurse</td><td>3.2</td><td>0</td><td>0.55</td></tr><tr><td>GP with PN/PA</td><td>9.7</td><td>0</td><td>0.28</td></tr><tr><td>Tri-monthly checks performed by (%)</td><td></td><td></td><td></td></tr><tr><td>General practitioner</td><td>16.1</td><td>9.1</td><td>0.57</td></tr><tr><td>Practice nurse</td><td>61.6</td><td>63.6</td><td>0.89</td></tr><tr><td>Practice assistant</td><td>22.6</td><td>27.3</td><td>0.75</td></tr><tr><td>Insulin treatments provided by (%)</td><td></td><td></td><td></td></tr><tr><td>Internist</td><td>6.5**</td><td>63.6**</td><td><0.001</td></tr><tr><td>General practitioner</td><td>61.3</td><td>36.4</td><td>0.15</td></tr><tr><td>Practice nurse</td><td>16.1</td><td>18.2</td><td>0.88</td></tr><tr><td>Diabetes specialist nurse</td><td>67.7**</td><td>18.2**</td><td>0.005</td></tr><tr><td>Consultation between healthcare professionals (%)</td><td></td><td></td><td></td></tr><tr><td>General practitioner</td><td>100*</td><td>80.0*</td><td>0.02</td></tr><tr><td>Practice nurse</td><td>71.4</td><td>70.0</td><td>0.93</td></tr></table>
<table><tr><td>Practice assistant</td><td>46.4</td><td>40.0</td><td>0.73</td></tr><tr><td>Diabetes specialist nurse</td><td>78.6**</td><td>30.0**</td><td>0.005</td></tr><tr><td>Dietician</td><td>50.0*</td><td>10.0*</td><td>0.03</td></tr><tr><td>Estimated percentage of patients that received education</td><td></td><td></td><td></td></tr><tr><td>Diet % (sd)</td><td>86.7 (17.9)</td><td>83.5 (28.7)</td><td>0.91</td></tr><tr><td>Exercise % (sd)</td><td>89.6 (16.0)</td><td>76.0 (29.5)</td><td>0.17</td></tr><tr><td>Smoking behavior % (sd)</td><td>90.0 (11.4)</td><td>73.3 (44.2)</td><td>0.17</td></tr><tr><td>Foot examination % (sd)</td><td>89.3 (17.0)</td><td>69.5 (38.3)</td><td>0.14</td></tr><tr><td>Education on diet, exercise, foot examination or smoking behavior.</td><td></td><td></td><td></td></tr><tr><td>by DSN (%)</td><td>35.0*</td><td>0.0*</td><td>0.04</td></tr><tr><td>by GP (%)</td><td>61.3</td><td>81.8</td><td>0.24</td></tr><tr><td>by PN/PA (%)</td><td>87.1</td><td>90.0</td><td>0.74</td></tr><tr><td>Diabetes passport, often or always used in practice (%)</td><td>78.6*</td><td>40.0*</td><td>0.05</td></tr></table>
2942319db206f714981d4a6fe37bf6fe0ebcf8b612df32e5799f1b41942c8cae.png
complex
<table><tr><td>Plant part</td><td>Use</td><td>Use form</td><td>Percentage of users</td><td>Management</td></tr><tr><td>Stem</td><td>Mescal production</td><td>Whole stems are backed inside an earthen pit, grounded, fermented and distilled</td><td>100</td><td>Extraction of whole individuals from wild populations</td></tr><tr><td>Flower buds</td><td rowspan="2">Food</td><td>Flowering buds are boiled or roasted, coocked with eggs or hot chilli sauce</td><td>66</td><td>People extract the whole scape, to get the flowering buds</td></tr><tr><td>Floral scape</td><td>Roasted over the fire while working in the field</td><td>33</td><td>Extract the young whole floral scape</td></tr><tr><td rowspan="3">Leaf bases</td><td>Food</td><td>People ask for the backed leave bases to the mescal producer and eat them as candy</td><td>30</td><td rowspan="2">Leave bases remaining from mescal production</td></tr><tr><td rowspan="2">Medicine</td><td>An infusion of cooked agave leaf for lung affections</td><td>10</td></tr><tr><td>Applying a piece of fresh leaf (or roasted) directly to wounded area</td><td>33</td><td>Eventually cutting up one leaf</td></tr><tr><td rowspan="2">Floral escape</td><td>Fodder</td><td>Cattle eat the growing scape</td><td>40</td><td>Cattle eat the early floral scape while it is starting to grow</td></tr><tr><td>Construction</td><td>Used in small fences</td><td>16</td><td>Extract the whole floral scape</td></tr><tr><td>Whole plant</td><td>Religious</td><td>Agaves are transplanted from the wild to &#8220;little mountains&#8221; (<i>montecitos</i>) dedicated to the GuadalupeVirgin</td><td>10</td><td>Each year in December small agave individuals are transplanted from wild populations to home gardens</td></tr><tr><td rowspan="2">Uses of <i>Mescal</i></td><td>As medicine</td><td>A small glass of mezcal aliviate the stomach-ache, flu symptoms, fever and cold- weat</td><td>30</td><td rowspan="2">(produced from agave stems)</td></tr><tr><td>Ritual</td><td>A small glass of mezcal is offered to the death in the &#8220;ofrendas de muertos&#8221;</td><td>80</td></tr></table>
<table><tr><td>Plant part</td><td>Use</td><td>Use form</td></tr><tr><td>Stem</td><td>Mescal production</td><td>Whole stems are backed inside an earthen pit, grounded, fermented and distilled</td></tr><tr><td>Flower buds</td><td rowspan="2">Food</td><td>Flowering buds are boiled or roasted, coocked with eggs or hot chilli sauce</td></tr><tr><td>Floral scape</td><td>Roasted over the fire while working in the field</td></tr><tr><td rowspan="3">Leaf bases</td><td>Food</td><td>People ask for the backed leave bases to the mescal producer and eat them as candy</td></tr><tr><td rowspan="2">Medicine</td><td>An infusion of cooked agave leaf for lung affections</td></tr><tr><td>Applying a piece of fresh leaf (or roasted) directly to wounded area</td></tr><tr><td rowspan="2">Floral escape</td><td>Fodder</td><td>Cattle eat the growing scape</td></tr><tr><td>Construction</td><td>Used in small fences</td></tr><tr><td>Whole plant</td><td>Religious</td><td>Agaves are transplanted from the wild to “little mountains” (montecitos) dedicated to the GuadalupeVirgin</td></tr><tr><td rowspan="2">Uses of Mescal</td><td>As medicine</td><td>A small glass of mezcal aliviate the stomach-ache, flu symptoms, fever and cold- weat</td></tr><tr><td>Ritual</td><td>A small glass of mezcal is offered to the death in the “ofrendas de muertos”</td></tr></table>
<table><tr><td>Percentage of users</td><td>Management</td></tr><tr><td>100</td><td>Extraction of whole individuals from wild populations</td></tr><tr><td>66</td><td>People extract the whole scape, to get the flowering buds</td></tr><tr><td>33</td><td>Extract the young whole floral scape</td></tr><tr><td>30</td><td rowspan="2">Leave bases remaining from mescal production</td></tr><tr><td>10</td></tr><tr><td>33</td><td>Eventually cutting up one leaf</td></tr><tr><td>40</td><td>Cattle eat the early floral scape while it is starting to grow</td></tr><tr><td>16</td><td>Extract the whole floral scape</td></tr><tr><td>10</td><td>Each year in December small agave individuals are transplanted from wild populations to home gardens</td></tr><tr><td>30</td><td rowspan="2">(produced from agave stems)</td></tr><tr><td>80</td></tr></table>
ff93e365fbc1c05805ecdafd1dbe157a5193bdfba4b8764b3429b777796552db.png
simple
<table><tr><td>Items</td><td>Growth rate</td><td>ERR %</td><td>Weight of single cocoon, g</td><td>Weight of single shell, g</td><td>Shell ratio, %</td></tr><tr><td>DPPH</td><td>&#8722;0.366</td><td>&#8722;0.494</td><td>&#8722;0.737</td><td>&#8722;0.830<sup>*</sup></td><td>&#8722;0.798</td></tr><tr><td>ABTS</td><td>&#8722;0.271</td><td>&#8722;0.057</td><td>&#8722;0.138</td><td>&#8722;0.719</td><td>&#8722;0.786</td></tr><tr><td>Nitric oxide</td><td>&#8722;0.358</td><td>&#8722;0.717</td><td>&#8722;0.864<sup>*</sup></td><td>&#8722;0.322</td><td>&#8722;0.158</td></tr><tr><td>Superoxide</td><td>&#8722;0.847<sup>*</sup></td><td>&#8722;0.975<sup>**</sup></td><td>&#8722;0.794</td><td>&#8722;0.704</td><td>&#8722;0.613</td></tr><tr><td>Reducing Power</td><td>0.927<sup>**</sup></td><td>0.817<sup>*</sup></td><td>0.679</td><td>0.899<sup>*</sup></td><td>0.835<sup>*</sup></td></tr></table>
<table><tr><td>Items</td><td>Growth rate</td><td>ERR %</td><td>Weight of single cocoon, g</td><td>Weight of single shell, g</td></tr><tr><td>DPPH</td><td>−0.366</td><td>−0.494</td><td>−0.737</td><td>−0.830*</td></tr><tr><td>ABTS</td><td>−0.271</td><td>−0.057</td><td>−0.138</td><td>−0.719</td></tr><tr><td>Nitric oxide</td><td>−0.358</td><td>−0.717</td><td>−0.864*</td><td>−0.322</td></tr><tr><td>Superoxide</td><td>−0.847*</td><td>−0.975**</td><td>−0.794</td><td>−0.704</td></tr><tr><td>Reducing Power</td><td>0.927**</td><td>0.817*</td><td>0.679</td><td>0.899*</td></tr></table>
<table><tr><td>Shell ratio, %</td></tr><tr><td>−0.798</td></tr><tr><td>−0.786</td></tr><tr><td>−0.158</td></tr><tr><td>−0.613</td></tr><tr><td>0.835*</td></tr></table>
da51d962a7b72b614822a4debbf70802e2fbcbc8563e99a4255c0014580f192d.png
simple
<table><tr><td>Author</td><td>Mean (m) or median (M) follow-up (mo)</td><td>PSM</td><td>Local or distant recurrence</td></tr><tr><td>Rogers [9]</td><td>15.7 (m)</td><td>0</td><td>No</td></tr><tr><td>Dogra [10]</td><td>29.4 (m)</td><td>0</td><td>No</td></tr><tr><td>Nazemi [15]</td><td>4 (M)</td><td>0</td><td>No</td></tr><tr><td>Hemal [17]</td><td>8.3 (m)</td><td>NR</td><td>No</td></tr><tr><td>Abaza [12]</td><td>15.4 (m)</td><td>0</td><td>No</td></tr><tr><td>Klingler [3]</td><td>NR</td><td>0</td><td>NR</td></tr><tr><td>Lorenzo [13]</td><td>12 (M)</td><td>0</td><td>No</td></tr><tr><td>White [14]</td><td>10.5 (m)</td><td>NR</td><td>NR</td></tr><tr><td>Boger [16]</td><td>NR</td><td>NR</td><td>NR</td></tr><tr><td>Rogers [11]</td><td>NR</td><td>NR</td><td>NR</td></tr></table>
<table><tr><td>Author</td><td>Mean (m) or median (M) follow-up (mo)</td><td>PSM</td><td>Local or distant recurrence</td></tr><tr><td>Rogers [9]</td><td>15.7 (m)</td><td>0</td><td>No</td></tr><tr><td>Dogra [10]</td><td>29.4 (m)</td><td>0</td><td>No</td></tr><tr><td>Nazemi [15]</td><td>4 (M)</td><td>0</td><td>No</td></tr><tr><td>Hemal [17]</td><td>8.3 (m)</td><td>NR</td><td>No</td></tr><tr><td>Abaza [12]</td><td>15.4 (m)</td><td>0</td><td>No</td></tr><tr><td>Klingler [3]</td><td>NR</td><td>0</td><td>NR</td></tr><tr><td>Lorenzo [13]</td><td>12 (M)</td><td>0</td><td>No</td></tr><tr><td>White [14]</td><td>10.5 (m)</td><td>NR</td><td>NR</td></tr><tr><td>Boger [16]</td><td>NR</td><td>NR</td><td>NR</td></tr></table>
<table><tr><td>Author</td><td>Mean (m) or median (M) follow-up (mo)</td><td>PSM</td><td>Local or distant recurrence</td></tr><tr><td>Rogers [11]</td><td>NR</td><td>NR</td><td>NR</td></tr></table>
5903ef50a3b82b67978ffd2c501a8b6448193b12944181d1a2d6da742ed693bd.png
simple
<table><tr><td>Localisation</td><td>Gland</td><td>Type</td></tr><tr><td>Lips</td><td>Upper lip</td><td>Serous</td></tr><tr><td></td><td>Lower lip</td><td>Serous</td></tr><tr><td>Cheek</td><td>Buccal mucosa</td><td>Mixed (predominantly mucous)</td></tr><tr><td></td><td><i>Parotid</i></td><td>Serous</td></tr><tr><td>Hard palate</td><td>Postero-lateral hard palate</td><td>Mucous</td></tr><tr><td>Tongue</td><td>Von Ebner (dorsal)</td><td>Serous</td></tr><tr><td></td><td>Weber Blandin Nuhn (marginal)</td><td>Mixed (predominantly mucous)</td></tr><tr><td>Floor of mouth</td><td><i>Submandibular</i></td><td>Mixed (predominantly serous)</td></tr><tr><td></td><td><i>Sublingual</i></td><td>Mixed (predominantly mucous)</td></tr></table>
<table><tr><td>Localisation</td><td>Gland</td><td>Type</td></tr><tr><td>Lips</td><td>Upper lip</td><td>Serous</td></tr><tr><td></td><td>Lower lip</td><td>Serous</td></tr><tr><td>Cheek</td><td>Buccal mucosa</td><td>Mixed (predominantly mucous)</td></tr><tr><td></td><td>Parotid</td><td>Serous</td></tr><tr><td>Hard palate</td><td>Postero-lateral hard palate</td><td>Mucous</td></tr></table>
<table><tr><td>Localisation</td><td>Gland</td><td>Type</td></tr><tr><td>Tongue</td><td>Von Ebner (dorsal)</td><td>Serous</td></tr><tr><td></td><td>Weber Blandin Nuhn (marginal)</td><td>Mixed (predominantly mucous)</td></tr><tr><td>Floor of mouth</td><td>Submandibular</td><td>Mixed (predominantly serous)</td></tr><tr><td></td><td>Sublingual</td><td>Mixed (predominantly mucous)</td></tr></table>
080aee4f4b3ccd714fae45150fc59ffa616d4ec23fef2cedbea57c562aabd59f.png
complex
<table><tr><td>Cell source</td><td>No. of slices</td><td>Total number of counted cells</td><td colspan="8">Regional distribution of counted cells</td></tr><tr><td></td><td></td><td></td><td>U</td><td>M</td><td>L</td><td>CP</td><td>IZ</td><td>Medial</td><td>Middle</td><td>Lateral</td></tr><tr><td>GE</td><td>11</td><td>23556</td><td>8632</td><td>7219</td><td>4804</td><td>20655</td><td>2901</td><td>6522</td><td>8475</td><td>8559</td></tr><tr><td>cortical</td><td>11</td><td>21657</td><td>4911</td><td>5342</td><td>5555</td><td>15808</td><td>5849</td><td>5863</td><td>7546</td><td>8248</td></tr><tr><td>Mixed</td><td>10</td><td>20386</td><td>7430</td><td>6055</td><td>4344</td><td>17829</td><td>2557</td><td>5261</td><td>6814</td><td>8311</td></tr></table>
<table><tr><td>Cell source</td><td>No. of slices</td><td>Total number of counted cells</td><td colspan="5">Regional distribution of counted cells</td></tr><tr><td></td><td></td><td></td><td>U</td><td>M</td><td>L</td><td>CP</td><td>IZ</td></tr><tr><td>GE</td><td>11</td><td>23556</td><td>8632</td><td>7219</td><td>4804</td><td>20655</td><td>2901</td></tr><tr><td>cortical</td><td>11</td><td>21657</td><td>4911</td><td>5342</td><td>5555</td><td>15808</td><td>5849</td></tr><tr><td>Mixed</td><td>10</td><td>20386</td><td>7430</td><td>6055</td><td>4344</td><td>17829</td><td>2557</td></tr></table>
<table><tr><td colspan="3">Regional distribution of counted cells</td></tr><tr><td>Medial</td><td>Middle</td><td>Lateral</td></tr><tr><td>6522</td><td>8475</td><td>8559</td></tr><tr><td>5863</td><td>7546</td><td>8248</td></tr><tr><td>5261</td><td>6814</td><td>8311</td></tr></table>
6fd3d0fb877ad3bf2dcd1727657ce2aaaba1d770990590f2874328e57ee7d841.png
complex
<table><tr><td colspan="2">MRI finding</td><td>PCNSL</td><td>GBM</td><td><i>p</i>-value</td></tr><tr><td rowspan="3">Localization</td><td>only supratentorial</td><td>66.7%</td><td>98.1%</td><td>&lt;0.001</td></tr><tr><td>only infratentorial</td><td>5.5%</td><td>1.9%</td><td>0.308</td></tr><tr><td>supra- and infratentorial</td><td>27.7%</td><td>0%</td><td>&lt;0.001</td></tr><tr><td rowspan="4">Type of lesions</td><td>solitary demarcated lesion</td><td>3.7%</td><td>13%</td><td>0.046</td></tr><tr><td>solitary infiltrative type</td><td>20.4%</td><td>51.9%</td><td>0.121</td></tr><tr><td>multiple infiltrative lesions</td><td>51.9%</td><td>35.2%</td><td>0.081</td></tr><tr><td>diffuse infiltrative type</td><td>24.1%</td><td>0%</td><td>&lt;0.001</td></tr><tr><td rowspan="4">Type of enhancement</td><td>homogeneous</td><td>64.8%</td><td>0%</td><td>&lt;0.001</td></tr><tr><td>nonhomogeneous</td><td>14.8%</td><td>98.1%</td><td>&lt;0.001</td></tr><tr><td>diffuse infiltrative &#8211; worm-like, patchy, stripy...</td><td>20.4%</td><td>0%</td><td>&lt;0.001</td></tr><tr><td>presence of necrosis</td><td>5.6%</td><td>88.9%</td><td>&lt;0.001</td></tr><tr><td rowspan="4">Involvement of brain surface</td><td>without reaching brain surface</td><td>12.9%</td><td>11.1%</td><td>0.567</td></tr><tr><td>reaching brain surface</td><td>87%</td><td>88.9%</td><td>0.846</td></tr><tr><td>meningeal infiltration</td><td>35.2%</td><td>46.3%</td><td>0.240</td></tr><tr><td>ependymal infiltration</td><td>53.7%</td><td>37%</td><td>0.054</td></tr><tr><td colspan="2">Optic nerves, chiasma or tracts involvement</td><td>42.6%</td><td>5.6%</td><td>&lt;0.001</td></tr><tr><td colspan="2">Cranial nerves involvement (optical nerves and tracts excluded)</td><td>5.6%</td><td>0%</td><td>0.079</td></tr><tr><td colspan="2">Corpus callosum infiltration</td><td>42.6%</td><td>44.4%</td><td>0.846</td></tr><tr><td colspan="2">Butterfly pattern</td><td>24.1%</td><td>14.8%</td><td>0.224</td></tr><tr><td colspan="2">Basal ganglia involvement</td><td>55.6%</td><td>18.5%</td><td>&lt;0.001</td></tr><tr><td colspan="2">Cerebral cortex involvement</td><td>83.3%</td><td>51.9%</td><td>&lt;0.001</td></tr><tr><td rowspan="2"><sup>a</sup>DWI</td><td>free diffusion</td><td>1.9%</td><td>10.4%</td><td>0.189</td></tr><tr><td>restricted diffusion in some part of the solid</td><td>97%</td><td>89.6%</td><td>0.189</td></tr><tr><td colspan="2">Signs of bleeding</td><td>5.6%</td><td>44.4%</td><td>&lt;0.001</td></tr><tr><td colspan="2">Presence of vasogenic edema</td><td>92.6%</td><td>83.3%</td><td>0.139</td></tr></table>
<table><tr><td colspan="2">MRI finding</td><td>PCNSL</td></tr><tr><td rowspan="3">Localization</td><td>only supratentorial</td><td>66.7%</td></tr><tr><td>only infratentorial</td><td>5.5%</td></tr><tr><td>supra- and infratentorial</td><td>27.7%</td></tr><tr><td rowspan="4">Type of lesions</td><td>solitary demarcated lesion</td><td>3.7%</td></tr><tr><td>solitary infiltrative type</td><td>20.4%</td></tr><tr><td>multiple infiltrative lesions</td><td>51.9%</td></tr><tr><td>diffuse infiltrative type</td><td>24.1%</td></tr><tr><td rowspan="4">Type of enhancement</td><td>homogeneous</td><td>64.8%</td></tr><tr><td>nonhomogeneous</td><td>14.8%</td></tr><tr><td>diffuse infiltrative – worm-like, patchy, stripy...</td><td>20.4%</td></tr><tr><td>presence of necrosis</td><td>5.6%</td></tr><tr><td rowspan="4">Involvement of brain surface</td><td>without reaching brain surface</td><td>12.9%</td></tr><tr><td>reaching brain surface</td><td>87%</td></tr><tr><td>meningeal infiltration</td><td>35.2%</td></tr><tr><td>ependymal infiltration</td><td>53.7%</td></tr><tr><td colspan="2">Optic nerves, chiasma or tracts involvement</td><td>42.6%</td></tr><tr><td colspan="2">Cranial nerves involvement (optical nerves and tracts excluded)</td><td>5.6%</td></tr><tr><td colspan="2">Corpus callosum infiltration</td><td>42.6%</td></tr><tr><td colspan="2">Butterfly pattern</td><td>24.1%</td></tr><tr><td colspan="2">Basal ganglia involvement</td><td>55.6%</td></tr><tr><td colspan="2">Cerebral cortex involvement</td><td>83.3%</td></tr><tr><td rowspan="2">aDWI</td><td>free diffusion</td><td>1.9%</td></tr><tr><td>restricted diffusion in some part of the solid</td><td>97%</td></tr><tr><td colspan="2">Signs of bleeding</td><td>5.6%</td></tr><tr><td colspan="2">Presence of vasogenic edema</td><td>92.6%</td></tr></table>
<table><tr><td>GBM</td><td>p-value</td></tr><tr><td>98.1%</td><td><0.001</td></tr><tr><td>1.9%</td><td>0.308</td></tr><tr><td>0%</td><td><0.001</td></tr><tr><td>13%</td><td>0.046</td></tr><tr><td>51.9%</td><td>0.121</td></tr><tr><td>35.2%</td><td>0.081</td></tr><tr><td>0%</td><td><0.001</td></tr><tr><td>0%</td><td><0.001</td></tr><tr><td>98.1%</td><td><0.001</td></tr><tr><td>0%</td><td><0.001</td></tr><tr><td>88.9%</td><td><0.001</td></tr><tr><td>11.1%</td><td>0.567</td></tr><tr><td>88.9%</td><td>0.846</td></tr><tr><td>46.3%</td><td>0.240</td></tr><tr><td>37%</td><td>0.054</td></tr><tr><td>5.6%</td><td><0.001</td></tr><tr><td>0%</td><td>0.079</td></tr><tr><td>44.4%</td><td>0.846</td></tr><tr><td>14.8%</td><td>0.224</td></tr><tr><td>18.5%</td><td><0.001</td></tr><tr><td>51.9%</td><td><0.001</td></tr><tr><td>10.4%</td><td>0.189</td></tr><tr><td>89.6%</td><td>0.189</td></tr><tr><td>44.4%</td><td><0.001</td></tr><tr><td>83.3%</td><td>0.139</td></tr></table>
71138a132f0fc501a54e3f35788b0e716fac12ee5b4046676da99e048846c8da.png
simple
<table><tr><td>Sequencing results</td><td>Number of total raw reads</td><td>60,866,926</td></tr><tr><td> </td><td>Number of total clean reads</td><td>51,606,364</td></tr><tr><td> </td><td>Number of total clean nucleotides (nt)</td><td>4,644,572,760</td></tr><tr><td> </td><td>Q20 percentage of total clean reads</td><td>95.92%</td></tr><tr><td> </td><td>GC percentage of total clean nucleotides</td><td>51.26%</td></tr><tr><td> </td><td>N percentage of total clean nucleotides</td><td>0.00%</td></tr><tr><td>Assembling results</td><td>Number of unigenes</td><td>38,504 (5,372 into distinct clusters; 33,132 singletons)</td></tr><tr><td> </td><td>Total length (nt) of total unigenes</td><td>21,977,286</td></tr><tr><td> </td><td>Mean length (nt) of total unigenes</td><td>571</td></tr><tr><td> </td><td>N50 (nt) of total unigenes</td><td>711</td></tr><tr><td>Annotation</td><td>Unigenes with Nr database</td><td>25,456 (66% of 38,504 unigenes)</td></tr><tr><td>(E-value &lt; =1e-5)</td><td>Unigenes with Nt database</td><td>20,554 (53%)</td></tr><tr><td> </td><td>Unigenes with Swiss-Prot database</td><td>17,651 (46%)</td></tr><tr><td> </td><td>Unigenes with KEGG database</td><td>16,622 (43%), 257 pathways</td></tr><tr><td> </td><td>Unigenes with COG database</td><td>7,204 (19%), 25 functional categories</td></tr><tr><td> </td><td>Unigenes with GO database</td><td>16,588 (43%), 62 subcategories grouped to 3 main categories</td></tr><tr><td> </td><td>Biological process</td><td>27 sub-categories</td></tr><tr><td> </td><td>Cellular component</td><td>17 sub-categories</td></tr><tr><td> </td><td>Molecular function</td><td>18 sub-categories</td></tr><tr><td> </td><td>Total unigenes annotated</td><td>26,650 (69% of 38,504 unigenes)</td></tr></table>
<table><tr><td>Sequencing results</td><td>Number of total raw reads</td><td>60,866,926</td></tr><tr><td></td><td>Number of total clean reads</td><td>51,606,364</td></tr><tr><td></td><td>Number of total clean nucleotides (nt)</td><td>4,644,572,760</td></tr><tr><td></td><td>Q20 percentage of total clean reads</td><td>95.92%</td></tr><tr><td></td><td>GC percentage of total clean nucleotides</td><td>51.26%</td></tr><tr><td></td><td>N percentage of total clean nucleotides</td><td>0.00%</td></tr><tr><td>Assembling results</td><td>Number of unigenes</td><td>38,504 (5,372 into distinct clusters; 33,132 singletons)</td></tr><tr><td></td><td>Total length (nt) of total unigenes</td><td>21,977,286</td></tr><tr><td></td><td>Mean length (nt) of total unigenes</td><td>571</td></tr><tr><td></td><td>N50 (nt) of total unigenes</td><td>711</td></tr><tr><td>Annotation</td><td>Unigenes with Nr database</td><td>25,456 (66% of 38,504 unigenes)</td></tr><tr><td>(E-value < =1e-5)</td><td>Unigenes with Nt database</td><td>20,554 (53%)</td></tr><tr><td></td><td>Unigenes with Swiss-Prot database</td><td>17,651 (46%)</td></tr><tr><td></td><td>Unigenes with KEGG database</td><td>16,622 (43%), 257 pathways</td></tr><tr><td></td><td>Unigenes with COG database</td><td>7,204 (19%), 25 functional categories</td></tr><tr><td></td><td>Unigenes</td><td>16,588 (43%), 62 subca</td></tr></table>
<table><tr><td>Sequencing results</td><td>Number of total raw reads</td><td>60,866,926</td></tr><tr><td></td><td> with GO database</td><td>tegories grouped to 3 main categories</td></tr><tr><td></td><td>Biological process</td><td>27 sub-categories</td></tr><tr><td></td><td>Cellular component</td><td>17 sub-categories</td></tr><tr><td></td><td>Molecular function</td><td>18 sub-categories</td></tr><tr><td></td><td>Total unigenes annotated</td><td>26,650 (69% of 38,504 unigenes)</td></tr></table>
52141c58c4f31ca0304bfa8efbbda681179704a8125749c54cd5d66917b051e8.png
complex
<table><tr><td></td><td></td><td colspan="2">"gold standard" = result of sentinel node biopsy</td><td></td></tr><tr><td></td><td></td><td>occult metastatic disease: Yes</td><td>occult metastatic disease: No</td><td></td></tr><tr><td>new predictive marker for occult metastatic disease (ECAD)</td><td>Low ECAD</td><td>true positive</td><td>false positive</td><td>all test positives</td></tr><tr><td></td><td>expression</td><td>a</td><td>b</td><td>a + b</td></tr><tr><td></td><td>High ECAD</td><td>c</td><td>d</td><td>all test</td></tr><tr><td></td><td>expression</td><td>false negative</td><td>true negative</td><td>negatives</td></tr><tr><td></td><td></td><td></td><td></td><td>c + d</td></tr><tr><td></td><td></td><td>a + c</td><td>b + d</td><td></td></tr><tr><td></td><td></td><td>all with occult</td><td>all without occult</td><td></td></tr><tr><td></td><td></td><td>disease</td><td>disease</td><td></td></tr></table>
<table><tr><td></td><td></td><td colspan="2">"gold standard" = result of sentinel node biopsy</td><td></td></tr><tr><td></td><td></td><td>occult metastatic disease: Yes</td><td>occult metastatic disease: No</td><td></td></tr><tr><td>new predictive marker for occult metastatic disease (ECAD)</td><td>Low ECAD</td><td>true positive</td><td>false positive</td><td>all test positives</td></tr></table>
<table><tr><td></td><td></td><td colspan="2">"gold standard" = result of sentinel node biopsy</td><td></td></tr><tr><td></td><td>expression</td><td>a</td><td>b</td><td>a + b</td></tr><tr><td></td><td>High ECAD</td><td>c</td><td>d</td><td>all test</td></tr><tr><td></td><td>expression</td><td>false negative</td><td>true negative</td><td>negatives</td></tr><tr><td></td><td></td><td></td><td></td><td>c + d</td></tr><tr><td></td><td></td><td>a + c</td><td>b + d</td><td></td></tr><tr><td></td><td></td><td>all with occult</td><td>all without occult</td><td></td></tr><tr><td></td><td></td><td>disease</td><td>disease</td><td></td></tr></table>
cabbe8a22342cb5a8736a0a989dc908a96a9a26532c7fc47c2f97fa2912bdf66.png
complex
<table><tr><td rowspan="2" colspan="2">Variable</td><td>CH group</td><td>CR group</td></tr><tr><td>(N = 313)</td><td>(N = 313)</td></tr><tr><td rowspan="2">Gender, <i>n</i> (%)</td><td>Male</td><td>167 (53.4)</td><td>170 (54.3)</td></tr><tr><td>Female</td><td>146 (46.6)</td><td>143 (45.7)</td></tr><tr><td colspan="2">Age [years], mean (SD)</td><td>50.8 (14.6)</td><td>48.8 (14.0)</td></tr><tr><td colspan="2">Weight [kg], mean (SD)</td><td>81.8 (16.4)</td><td>83.4 (17.4)</td></tr><tr><td colspan="2">BMI [kg/m<sup>2</sup>], mean (SD)</td><td>28.0 (5.1)</td><td>28.6 (5.7)</td></tr><tr><td rowspan="4">Race, <i>n</i> (%)</td><td>Asian</td><td>14 (4.5)</td><td>7 (2.2)</td></tr><tr><td>Black</td><td>13 (4.2)</td><td>17 (5.4)</td></tr><tr><td>White</td><td>246 (78.6)</td><td>253 (80.8)</td></tr><tr><td>Other</td><td>40 (12.8)</td><td>36 (11.5)</td></tr><tr><td rowspan="2">GI comorbidities, <i>n</i> (%)</td><td>Dyspepsia-like</td><td>204 (65.2)</td><td>201 (64.2)</td></tr><tr><td>IBS-like</td><td>44 (14.1)</td><td>41 (13.1)</td></tr><tr><td>Current smoker, <i>n</i> (%)</td><td> </td><td>79 (25.2)</td><td>83 (26.5)</td></tr><tr><td>ReQuest<sup>TM</sup> total score</td><td> </td><td>10.23</td><td>11.37</td></tr><tr><td>GERDyzer<sup>TM</sup> sum score</td><td> </td><td>46.12</td><td>49.45</td></tr></table>
<table><tr><td rowspan="2" colspan="2">Variable</td><td>CH group</td><td>CR group</td></tr><tr><td>(N = 313)</td><td>(N = 313)</td></tr><tr><td rowspan="2">Gender, n (%)</td><td>Male</td><td>167 (53.4)</td><td>170 (54.3)</td></tr><tr><td>Female</td><td>146 (46.6)</td><td>143 (45.7)</td></tr><tr><td colspan="2">Age [years], mean (SD)</td><td>50.8 (14.6)</td><td>48.8 (14.0)</td></tr></table>
<table><tr><td colspan="2">Weight [kg], mean (SD)</td><td>81.8 (16.4)</td><td>83.4 (17.4)</td></tr><tr><td colspan="2">BMI [kg/m2], mean (SD)</td><td>28.0 (5.1)</td><td>28.6 (5.7)</td></tr><tr><td rowspan="4">Race, n (%)</td><td>Asian</td><td>14 (4.5)</td><td>7 (2.2)</td></tr><tr><td>Black</td><td>13 (4.2)</td><td>17 (5.4)</td></tr><tr><td>White</td><td>246 (78.6)</td><td>253 (80.8)</td></tr><tr><td>Other</td><td>40 (12.8)</td><td>36 (11.5)</td></tr><tr><td rowspan="2">GI comorbidities, n (%)</td><td>Dyspepsia-like</td><td>204 (65.2)</td><td>201 (64.2)</td></tr><tr><td>IBS-like</td><td>44 (14.1)</td><td>41 (13.1)</td></tr><tr><td>Current smoker, n (%)</td><td></td><td>79 (25.2)</td><td>83 (26.5)</td></tr><tr><td>ReQuestTM total score</td><td></td><td>10.23</td><td>11.37</td></tr><tr><td>GERDyzerTM sum score</td><td></td><td>46.12</td><td>49.45</td></tr></table>
f52f534494a0508814c3c67e21e1584801cc6ff155bbc47c388992e691574f2e.png
simple
<table><tr><td>Gases</td><td>Training Set</td><td>Unlabeled Set</td><td>Test Set</td></tr><tr><td>Carbon monoxide</td><td>116</td><td>116</td><td>116</td></tr><tr><td>Toluene</td><td>132</td><td>132</td><td>132</td></tr><tr><td>Formaldehyde</td><td>253</td><td>253</td><td>253</td></tr><tr><td>All-3</td><td>501</td><td>501</td><td>501</td></tr></table>
<table><tr><td>Gases</td><td>Training Set</td><td>Unlabeled Set</td><td>Test Set</td></tr><tr><td>Carbon monoxide</td><td>116</td><td>116</td><td>116</td></tr><tr><td>Toluene</td><td>132</td><td>132</td><td>132</td></tr></table>
<table><tr><td>Gases</td><td>Training Set</td><td>Unlabeled Set</td><td>Test Set</td></tr><tr><td>Formaldehyde</td><td>253</td><td>253</td><td>253</td></tr><tr><td>All-3</td><td>501</td><td>501</td><td>501</td></tr></table>
68b39dcd654b9cbfb329e06b795605851ff43d99d5b0d2a520e50e04b8666dbc.png
simple
<table><tr><td>Boys</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Overall</td><td>Children</td><td>Adolescents</td><td>Normalweight</td><td>Overweight</td></tr><tr><td>Chocolate and snacks</td><td>23.2</td><td>20.5</td><td>25.3</td><td>22.5</td><td>25.1</td></tr><tr><td>Biscuits and ice creams</td><td>18.5</td><td>19.2</td><td>18.0</td><td>18.4</td><td>18.8</td></tr><tr><td>Fat Meat</td><td>10.9</td><td>13.3</td><td>9.1</td><td>11.5</td><td>9.3</td></tr><tr><td>Filled cakes and sweets</td><td>8.0</td><td>6.7</td><td>8.9</td><td>8.3</td><td>6.9</td></tr><tr><td>Fried potatoes</td><td>7.5</td><td>6.6</td><td>8.2</td><td>8.1</td><td>5.4</td></tr><tr><td>Oils and condiments</td><td>5.6</td><td>3.7</td><td>7.1</td><td>5.1</td><td>7.2</td></tr><tr><td>Lean meet</td><td>5.1</td><td>7.1</td><td>3.6</td><td>5.4</td><td>4.2</td></tr><tr><td>Cold cuts</td><td>4.9</td><td>4.9</td><td>4.9</td><td>5.4</td><td>3.3</td></tr><tr><td>Bread and pasta</td><td>4.4</td><td>4.4</td><td>4.5</td><td>3.8</td><td>6.3</td></tr><tr><td>Pizza</td><td>4.1</td><td>4.9</td><td>3.4</td><td>4.0</td><td>4.2</td></tr><tr><td>Juices and drinks</td><td>2.4</td><td>2.4</td><td>2.4</td><td>2.3</td><td>2.7</td></tr><tr><td>Dairy products</td><td>1.5</td><td>0.8</td><td>2.0</td><td>1.4</td><td>1.8</td></tr><tr><td>Vegetables</td><td>1.3</td><td>2.4</td><td>0.5</td><td>1.3</td><td>1.5</td></tr><tr><td>Non-sweet fruits and cereals</td><td>1.0</td><td>1.8</td><td>0.3</td><td>0.7</td><td>1.8</td></tr><tr><td>Eggs</td><td>0.7</td><td>0.5</td><td>0.9</td><td>0.7</td><td>0.9</td></tr><tr><td>Fried fish</td><td>0.6</td><td>0.5</td><td>0.7</td><td>0.6</td><td>0.6</td></tr><tr><td>Fish</td><td>0.3</td><td>0.5</td><td>0.1</td><td>0.4</td><td>0.0</td></tr><tr><td>Sweet fruit</td><td>0.1</td><td>0.0</td><td>0.3</td><td>0.1</td><td>0.3</td></tr><tr><td>Girls</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Overall</td><td>Children</td><td>Adolescents</td><td>Normalweight</td><td>Overweight</td></tr><tr><td>Chocolate and snacks</td><td>26.5</td><td>25.6</td><td>27.2</td><td>27.2</td><td>22.4</td></tr><tr><td>Biscuits and ice creams</td><td>16.3</td><td>17.0</td><td>15.7</td><td>15.7</td><td>19.5</td></tr><tr><td>Bread and pasta</td><td>9.2</td><td>9.8</td><td>8.8</td><td>8.2</td><td>15.1</td></tr><tr><td>Oils and condiments</td><td>8.0</td><td>4.5</td><td>10.8</td><td>7.9</td><td>8.3</td></tr><tr><td>Fried potatoes</td><td>7.6</td><td>6.9</td><td>8.1</td><td>7.9</td><td>5.4</td></tr><tr><td>Filled cakes and sweets</td><td>7.0</td><td>6.7</td><td>7.2</td><td>7.4</td><td>4.4</td></tr><tr><td>Fat Meat</td><td>5.4</td><td>4.8</td><td>5.9</td><td>5.6</td><td>4.4</td></tr><tr><td>Cold cuts</td><td>5.3</td><td>5.3</td><td>5.4</td><td>5.2</td><td>5.9</td></tr><tr><td>Lean meet</td><td>4.2</td><td>6.1</td><td>2.7</td><td>4.3</td><td>3.9</td></tr><tr><td>Juices and drinks</td><td>2.5</td><td>3.0</td><td>2.1</td><td>2.3</td><td>3.9</td></tr><tr><td>Pizza</td><td>2.5</td><td>3.5</td><td>1.7</td><td>2.4</td><td>2.9</td></tr><tr><td>Dairy products</td><td>1.8</td><td>1.6</td><td>2.0</td><td>1.9</td><td>1.5</td></tr><tr><td>Non-sweet fruits and cereals</td><td>1.0</td><td>1.4</td><td>0.7</td><td>1.1</td><td>0.5</td></tr><tr><td>Vegetables</td><td>0.9</td><td>1.6</td><td>0.4</td><td>1.0</td><td>0.5</td></tr><tr><td>Sweet fruit</td><td>0.6</td><td>1.1</td><td>0.3</td><td>0.7</td><td>0.5</td></tr><tr><td>Eggs</td><td>0.5</td><td>0.6</td><td>0.4</td><td>0.4</td><td>1.0</td></tr><tr><td>Fish</td><td>0.4</td><td>0.3</td><td>0.4</td><td>0.4</td><td>0.0</td></tr><tr><td>Fried fish</td><td>0.3</td><td>0.2</td><td>0.4</td><td>0.3</td><td>0.0</td></tr></table>
<table><tr><td>Boys</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Overall</td><td>Children</td><td>Adolescents</td><td>Normalweight</td><td>Overweight</td></tr><tr><td>Chocolate and snacks</td><td>23.2</td><td>20.5</td><td>25.3</td><td>22.5</td><td>25.1</td></tr><tr><td>Biscuits and</td><td></td><td></td><td></td><td></td><td>18.</td></tr></table>
<table><tr><td> ice creams</td><td>18.5</td><td>19.2</td><td>18.0</td><td>18.4</td><td>8</td></tr><tr><td>Fat Meat</td><td>10.9</td><td>13.3</td><td>9.1</td><td>11.5</td><td>9.3</td></tr><tr><td>Filled cakes and sweets</td><td>8.0</td><td>6.7</td><td>8.9</td><td>8.3</td><td>6.9</td></tr><tr><td>Fried potatoes</td><td>7.5</td><td>6.6</td><td>8.2</td><td>8.1</td><td>5.4</td></tr><tr><td>Oils and condiments</td><td>5.6</td><td>3.7</td><td>7.1</td><td>5.1</td><td>7.2</td></tr><tr><td>Lean meet</td><td>5.1</td><td>7.1</td><td>3.6</td><td>5.4</td><td>4.2</td></tr><tr><td>Cold cuts</td><td>4.9</td><td>4.9</td><td>4.9</td><td>5.4</td><td>3.3</td></tr><tr><td>Bread and pasta</td><td>4.4</td><td>4.4</td><td>4.5</td><td>3.8</td><td>6.3</td></tr><tr><td>Pizza</td><td>4.1</td><td>4.9</td><td>3.4</td><td>4.0</td><td>4.2</td></tr><tr><td>Juices and drinks</td><td>2.4</td><td>2.4</td><td>2.4</td><td>2.3</td><td>2.7</td></tr><tr><td>Dairy products</td><td>1.5</td><td>0.8</td><td>2.0</td><td>1.4</td><td>1.8</td></tr><tr><td>Vegetables</td><td>1.3</td><td>2.4</td><td>0.5</td><td>1.3</td><td>1.5</td></tr><tr><td>Non-sweet fruits and cereals</td><td>1.0</td><td>1.8</td><td>0.3</td><td>0.7</td><td>1.8</td></tr><tr><td>Eggs</td><td>0.7</td><td>0.5</td><td>0.9</td><td>0.7</td><td>0.9</td></tr><tr><td>Fried fish</td><td>0.6</td><td>0.5</td><td>0.7</td><td>0.6</td><td>0.6</td></tr><tr><td>Fish</td><td>0.3</td><td>0.5</td><td>0.1</td><td>0.4</td><td>0.0</td></tr><tr><td>Sweet fruit</td><td>0.1</td><td>0.0</td><td>0.3</td><td>0.1</td><td>0.3</td></tr><tr><td>Girls</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Overall</td><td>Children</td><td>Adolescents</td><td>Normalweight</td><td>Overweight</td></tr><tr><td>Chocolate and snacks</td><td>26.5</td><td>25.6</td><td>27.2</td><td>27.2</td><td>22.4</td></tr><tr><td>Biscuits and ice creams</td><td>16.3</td><td>17.0</td><td>15.7</td><td>15.7</td><td>19.5</td></tr><tr><td>Bread and pasta</td><td>9.2</td><td>9.8</td><td>8.8</td><td>8.2</td><td>15.1</td></tr><tr><td>Oils and condiments</td><td>8.0</td><td>4.5</td><td>10.8</td><td>7.9</td><td>8.3</td></tr><tr><td>Fried potatoes</td><td>7.6</td><td>6.9</td><td>8.1</td><td>7.9</td><td>5.4</td></tr><tr><td>Filled cakes and sweets</td><td>7.0</td><td>6.7</td><td>7.2</td><td>7.4</td><td>4.4</td></tr><tr><td>Fat Meat</td><td>5.4</td><td>4.8</td><td>5.9</td><td>5.6</td><td>4.4</td></tr><tr><td>Cold cuts</td><td>5.3</td><td>5.3</td><td>5.4</td><td>5.2</td><td>5.9</td></tr><tr><td>Lean meet</td><td>4.2</td><td>6.1</td><td>2.7</td><td>4.3</td><td>3.9</td></tr><tr><td>Juices and drinks</td><td>2.5</td><td>3.0</td><td>2.1</td><td>2.3</td><td>3.9</td></tr><tr><td>Pizza</td><td>2.5</td><td>3.5</td><td>1.7</td><td>2.4</td><td>2.9</td></tr><tr><td>Dairy products</td><td>1.8</td><td>1.6</td><td>2.0</td><td>1.9</td><td>1.5</td></tr><tr><td>Non-sweet fruits and cereals</td><td>1.0</td><td>1.4</td><td>0.7</td><td>1.1</td><td>0.5</td></tr><tr><td>Vegetables</td><td>0.9</td><td>1.6</td><td>0.4</td><td>1.0</td><td>0.5</td></tr><tr><td>Sweet fruit</td><td>0.6</td><td>1.1</td><td>0.3</td><td>0.7</td><td>0.5</td></tr><tr><td>Eggs</td><td>0.5</td><td>0.6</td><td>0.4</td><td>0.4</td><td>1.0</td></tr><tr><td>Fish</td><td>0.4</td><td>0.3</td><td>0.4</td><td>0.4</td><td>0.0</td></tr><tr><td>Fried fish</td><td>0.3</td><td>0.2</td><td>0.4</td><td>0.3</td><td>0.0</td></tr></table>
f644fcae7c5f91bd325c869e0fbeb1a921b32b2731769ac22e25a4e3158f7cf3.png
complex
<table><tr><td rowspan="2">Characteristics</td><td>Patients (n=62)</td><td colspan="2">EGFR overexpression (n=51)</td><td colspan="2">EGFR FISH (n=22)</td></tr><tr><td>No. (%)</td><td>No./Subgroup (%)</td><td>P value</td><td>No./Subgroup (%)</td><td>P value</td></tr><tr><td>Age (year)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> &lt;=65</td><td>47 (75.8)</td><td>36/47 (76.6)</td><td rowspan="2">0.052<sup>b</sup></td><td>17/47 (36.2)</td><td rowspan="2">0.842</td></tr><tr><td> &gt;65</td><td>15 (24.2)</td><td>15/15 (100.0)</td><td>5/15 (33.3)</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Male</td><td>50 (80.6)</td><td>39/50 (78.0)</td><td rowspan="2">0.102<sup>b</sup></td><td>18/50 (36.0)</td><td rowspan="2">1.000<sup>b</sup></td></tr><tr><td> Female</td><td>12 (19.4)</td><td>12/12 (100.0)</td><td>4/12 (33.3)</td></tr><tr><td>Performance status</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> 0-1</td><td>59 (95.2)</td><td>48/59 (81.4)</td><td rowspan="2">1.000<sup>b</sup></td><td>22/59 (37.3)</td><td rowspan="2">0.546<sup>b</sup></td></tr><tr><td> 2</td><td>3 (4.8)</td><td>3/3 (100.0)</td><td>0/3 (0.0)</td></tr><tr><td>Smoking</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Never</td><td>23 (37.1)</td><td>22/23 (95.7)</td><td rowspan="2">0.042<sup>b</sup></td><td>8/23 (34.8)</td><td rowspan="2">0.929</td></tr><tr><td> Ever</td><td>39 (62.9)</td><td>29/39 (74.4)</td><td>14/39 (35.9)</td></tr><tr><td>Histologic grade</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> G1</td><td>6 (9.7)</td><td>5/6 (83.3)</td><td rowspan="3">0.305<sup>b</sup></td><td>3/6 (50.0)</td><td rowspan="3">0.004<sup>b</sup></td></tr><tr><td> G2</td><td>17 (27.4)</td><td>12/17 (70.6)</td><td>11/17 (64.7)</td></tr><tr><td> G3</td><td>39 (62.9)</td><td>34/39 (87.2)</td><td>8/39 (20.5)</td></tr><tr><td>No. of previous chemotherapy</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> None or 1</td><td>43 (69.4)</td><td>41/43 (95.3)</td><td rowspan="2">&lt;0.001<sup>b</sup></td><td>15/43 (34.9)</td><td rowspan="2">0.882</td></tr><tr><td> 2 or more</td><td>19 (30.6)</td><td>10/19 (52.6)</td><td>7/19 (36.8)</td></tr><tr><td>Disease extent</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td> Locally advanced</td><td>6 (9.7)</td><td>3/6 (50.0)</td><td rowspan="2">0.063<sup>b</sup></td><td>2/6 (33.3)</td><td rowspan="2">1.000<sup>b</sup></td></tr><tr><td> Metastatic</td><td>56 (90.3)</td><td>48/56(85.7)</td><td>20/56 (35.7)</td></tr></table>
<table><tr><td rowspan="2">Characteristics</td><td>Patients (n=62)</td><td colspan="2">EGFR overexpression (n=51)</td><td colspan="2">EGFR FISH (n=22)</td></tr><tr><td>No. (%)</td><td>No./Subgroup (%)</td><td>P value</td><td>No./Subgroup (%)</td><td>P value</td></tr><tr><td>Age (year)</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td><=65</td><td>47 (75.8)</td><td>36/47 (76.6)</td><td rowspan="2">0.052b</td><td>17/47 (36.2)</td><td rowspan="2">0.842</td></tr><tr><td>>65</td><td>15 (24.2)</td><td>15/15 (100.0)</td><td>5/15 (33.3)</td></tr><tr><td>Gender</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Male</td><td>50 (80.6)</td><td>39/50 (78.0)</td><td>0.102b</td><td>18/50 (36.0)</td><td>1.000b</td></tr></table>
<table><tr><td>Female</td><td>12 (19.4)</td><td>12/12 (100.0)</td><td>0.102b</td><td>4/12 (33.3)</td><td>1.000b</td></tr><tr><td>Performance status</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>0-1</td><td>59 (95.2)</td><td>48/59 (81.4)</td><td rowspan="2">1.000b</td><td>22/59 (37.3)</td><td rowspan="2">0.546b</td></tr><tr><td>2</td><td>3 (4.8)</td><td>3/3 (100.0)</td><td>0/3 (0.0)</td></tr><tr><td>Smoking</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Never</td><td>23 (37.1)</td><td>22/23 (95.7)</td><td rowspan="2">0.042b</td><td>8/23 (34.8)</td><td rowspan="2">0.929</td></tr><tr><td>Ever</td><td>39 (62.9)</td><td>29/39 (74.4)</td><td>14/39 (35.9)</td></tr><tr><td>Histologic grade</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>G1</td><td>6 (9.7)</td><td>5/6 (83.3)</td><td rowspan="3">0.305b</td><td>3/6 (50.0)</td><td rowspan="3">0.004b</td></tr><tr><td>G2</td><td>17 (27.4)</td><td>12/17 (70.6)</td><td>11/17 (64.7)</td></tr><tr><td>G3</td><td>39 (62.9)</td><td>34/39 (87.2)</td><td>8/39 (20.5)</td></tr><tr><td>No. of previous chemotherapy</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>None or 1</td><td>43 (69.4)</td><td>41/43 (95.3)</td><td rowspan="2"><0.001b</td><td>15/43 (34.9)</td><td rowspan="2">0.882</td></tr><tr><td>2 or more</td><td>19 (30.6)</td><td>10/19 (52.6)</td><td>7/19 (36.8)</td></tr><tr><td>Disease extent</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Locally advanced</td><td>6 (9.7)</td><td>3/6 (50.0)</td><td rowspan="2">0.063b</td><td>2/6 (33.3)</td><td rowspan="2">1.000b</td></tr><tr><td>Metastatic</td><td>56 (90.3)</td><td>48/56(85.7)</td><td>20/56 (35.7)</td></tr></table>
7b6f9c45d4013f3fd8997a7b0da508990e608ee30d518f53097d1542ea137946.png
complex
<table><tr><td><i>Clinical features</i></td><td><i>Mean &#177; SD, n (%)</i></td></tr><tr><td>Age</td><td>66.5 &#177; 8.0</td></tr><tr><td>Weight</td><td>73.2 &#177; 8.5</td></tr><tr><td>Body mass index</td><td>27.8 &#177; 2.6</td></tr><tr><td colspan="2">Gender</td></tr><tr><td>Male</td><td>12 (60)</td></tr><tr><td>Female</td><td>8 (40)</td></tr><tr><td>Smoking</td><td>9 (45)</td></tr><tr><td colspan="2">Diseases</td></tr><tr><td>Hypertension</td><td>17 (85)</td></tr><tr><td>Heart failure</td><td>3 (15)</td></tr><tr><td>Diabetes</td><td>10 (50)</td></tr><tr><td colspan="2">Medication</td></tr><tr><td>Organic nitrates</td><td>0 (0)</td></tr><tr><td>Aspirin</td><td>20 (100)</td></tr><tr><td>Beta-blockers</td><td>14 (70)</td></tr><tr><td>Angiotensin inhibitors</td><td>9 (45)</td></tr><tr><td>Calcium channel blockers</td><td>5 (25)</td></tr><tr><td>Hypolipidaemics</td><td>13 (65)</td></tr></table>
<table><tr><td>Clinical features</td><td>Mean ± SD, n (%)</td></tr><tr><td>Age</td><td>66.5 ± 8.0</td></tr><tr><td>W</td><td>73.</td></tr></table>
<table><tr><td>Clinical features</td><td>Mean ± SD, n (%)</td></tr><tr><td>eight</td><td>2 ± 8.5</td></tr><tr><td>Body mass index</td><td>27.8 ± 2.6</td></tr><tr><td colspan="2">Gender</td></tr><tr><td>Male</td><td>12 (60)</td></tr><tr><td>Female</td><td>8 (40)</td></tr><tr><td>Smoking</td><td>9 (45)</td></tr><tr><td colspan="2">Diseases</td></tr><tr><td>Hypertension</td><td>17 (85)</td></tr><tr><td>Heart failure</td><td>3 (15)</td></tr><tr><td>Diabetes</td><td>10 (50)</td></tr><tr><td colspan="2">Medication</td></tr><tr><td>Organic nitrates</td><td>0 (0)</td></tr><tr><td>Aspirin</td><td>20 (100)</td></tr><tr><td>Beta-blockers</td><td>14 (70)</td></tr><tr><td>Angiotensin inhibitors</td><td>9 (45)</td></tr><tr><td>Calcium channel blockers</td><td>5 (25)</td></tr><tr><td>Hypolipidaemics</td><td>13 (65)</td></tr></table>
e1183f0359eeb8c71d0b81e03e01579af8341c163f358ff1411b725c9febf2bf.png
complex
<table><tr><td>Cell type</td><td>Action</td><td>References</td></tr><tr><td rowspan="3">Langerhans cells</td><td>Activate and proliferate Treg cells in resting state; limit activation of Treg cells in presence of pathogen</td><td>[116]</td></tr><tr><td>Induce Treg cells favoring flora tolerance with limited antigens presentation</td><td>[117]</td></tr><tr><td>Induce Treg cells by secretion of IL-10 and TGF-&#946;</td><td>[118]</td></tr><tr><td rowspan="2">Memory Treg cells</td><td>Localize to hair folliclesNon-migratory and non-responsive in normal skinProliferate and produce IL-17 in inflamed skin</td><td>[119]</td></tr><tr><td>Are activated, proliferated and differentiated into potent suppressorAttenuate autoimmune reactions in tissues upon repeated responses to antigens</td><td>[120]</td></tr><tr><td rowspan="2">Macrophages</td><td>Promote expression of the chemokine CCL22Induce migration and activation of Treg cells</td><td>[121]</td></tr><tr><td>Express M2-like TIM-4<sup>hi</sup>CD169<sup>+</sup>Act immunoregulatory function and promote engraftment of cardiac allografts</td><td>[122]</td></tr><tr><td rowspan="2">Mast cells</td><td>Act as intermediate at Treg cells dependent allograft tolerance via IL-9</td><td>[123]</td></tr><tr><td>Counteract Treg cell function through IL-6 and OX40/OX40L axis toward Th17 cell differentiation</td><td>[124]</td></tr><tr><td>Dermal dendritic cells</td><td>Are capable of antigen capture and presentation to CD4<sup>+</sup> T cells and Treg cells generation</td><td>[125]</td></tr><tr><td>Dermal regulatory cells</td><td>Induce Treg cells through PD-1 engagement with expression of ABCB5<sup>+</sup> molecules</td><td>[126]</td></tr><tr><td>Dermal fibroblasts</td><td>Induce proliferation of natural Treg cells with IL-15</td><td>[127]</td></tr><tr><td>Dermal stromal cells</td><td>Express CD90<sup>+</sup> and induce Tregs cells</td><td>[128]</td></tr></table>
<table><tr><td>Cell type</td><td>Action</td><td>References</td></tr><tr><td rowspan="3">Langerhans cells</td><td>Activate and proliferate Treg cells in resting state; limit activation of Treg cells in presence of pathogen</td><td>[116]</td></tr><tr><td>Induce Treg cells favoring flora tolerance with limited antigens presentation</td><td>[117]</td></tr><tr><td>Induce Treg cells by secretion of IL-10 and TGF-β</td><td>[118]</td></tr><tr><td rowspan="2">Memory Treg cells</td><td>Localize to hair folliclesNon-migratory and non-responsive in normal skinProliferate and produce IL-17 in inflamed skin</td><td>[119]</td></tr><tr><td>Are activated, proliferated and differentiated into potent suppressorAttenuate autoimmune reactions in tissues upon repeated responses to antigens</td><td>[120]</td></tr><tr><td rowspan="2">Macrophages</td><td>Promote expression of the chemokine CCL22Induce migration and activation of Treg cells</td><td>[121]</td></tr><tr><td>Express M2-like TIM-4hiCD169+Act immunoregulatory function and promote engraftment of cardiac allografts</td><td>[122]</td></tr><tr><td rowspan="2">Mast cells</td><td>Act as intermediate at Treg cells dependent allograft tolerance via IL-9</td><td>[123]</td></tr><tr><td>Counteract Treg cell function through IL-6 and OX40/OX40L axis toward Th17 cell differentiation</td><td>[124]</td></tr><tr><td>Dermal dendritic cells</td><td>Are capable of antigen capture and presentation to CD4+ T cells and Treg cells generation</td><td>[125]</td></tr></table>
<table><tr><td>Cell type</td><td>Action</td><td>References</td></tr><tr><td>Dermal regulatory cells</td><td>Induce Treg cells through PD-1 engagement with expression of ABCB5+ molecules</td><td>[126]</td></tr><tr><td>Dermal fibroblasts</td><td>Induce proliferation of natural Treg cells with IL-15</td><td>[127]</td></tr><tr><td>Dermal stromal cells</td><td>Express CD90+ and induce Tregs cells</td><td>[128]</td></tr></table>
bf25897f8cc89d60b61ec8db222caa7871c58b8aaacf2bc3b74ce896af261061.png
complex
<table><tr><td rowspan="3">Variable</td><td colspan="8">Training group (<i>n</i> = 77)</td><td colspan="8">Validation group (<i>n</i> = 119)</td></tr><tr><td colspan="2">Low Risk</td><td colspan="2">High Risk</td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted#</td><td colspan="2">Low Risk</td><td colspan="2">High Risk</td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted#</td></tr><tr><td>R</td><td>N</td><td>R</td><td>N</td><td>HR (95% CI)</td><td><i>P</i></td><td>HR (95% CI)</td><td><i>P</i></td><td>R</td><td>N</td><td>R</td><td>N</td><td>HR (95% CI)</td><td><i>P</i></td><td>HR (95% CI)</td><td><i>P</i></td></tr><tr><td>ACSL1</td><td>10</td><td>51</td><td>12</td><td>26</td><td>2.93 (1.26&#8211;6.81)</td><td>0.013</td><td>2.34 (0.91&#8211;6.02)</td><td>0.082</td><td>5</td><td>61</td><td>13</td><td>58</td><td>3.12 (1.11&#8211;8.76)</td><td>0.021</td><td>3.86 (1.16&#8211;12.79)</td><td>0.017</td></tr><tr><td>ACSL4</td><td>9</td><td>54</td><td>13</td><td>23</td><td>4.92 (2.09&#8211;11.62)</td><td>0</td><td>5.6 (2.19&#8211;14.32)</td><td>0</td><td>8</td><td>78</td><td>10</td><td>41</td><td>2.59 (1.02&#8211;6.57)</td><td>0.045</td><td>2.31 (0.85&#8211;6.27)</td><td>0.1</td></tr><tr><td>SCD</td><td>3</td><td>26</td><td>19</td><td>51</td><td>3.57 (1.06&#8211;12.08)</td><td>0.018</td><td>3.13 (0.9&#8211;10.93)</td><td>0.046</td><td>3</td><td>57</td><td>15</td><td>62</td><td>5.32 (1.54&#8211;18.38)</td><td>0.002</td><td>4.08 (1.12&#8211;14.9)</td><td>0.017</td></tr><tr><td>x3</td><td>6</td><td>46</td><td>16</td><td>31</td><td>5.36 (2.09&#8211;13.74)</td><td>0.000</td><td>4.99 (1.81&#8211;13.77)</td><td>0.001</td><td>2</td><td>58</td><td>16</td><td>61</td><td>9 (2.07&#8211;39.21)</td><td>0.0002</td><td>8.68 (1.9&#8211;39.66)</td><td>6E-04</td></tr></table>
<table><tr><td rowspan="3">Variable</td><td colspan="8">Training group (n = 77)</td><td colspan="8">Validation group (n = 119)</td></tr><tr><td colspan="2">Low Risk</td><td colspan="2">High Risk</td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted#</td><td colspan="2">Low Risk</td><td colspan="2">High Risk</td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted#</td></tr><tr><td>R</td><td>N</td><td>R</td><td>N</td><td>HR (95% CI)</td><td>P</td><td>HR (95% CI)</td><td>P</td><td>R</td><td>N</td><td>R</td><td>N</td><td>HR (95% CI)</td><td>P</td><td>HR (95% CI)</td><td>P</td></tr><tr><td>ACSL1</td><td>10</td><td>51</td><td>12</td><td>26</td><td>2.93 (1.26–6.81)</td><td>0.013</td><td>2.34 (0.91–6.02)</td><td>0.082</td><td>5</td><td>61</td><td>13</td><td>58</td><td>3.12 (1.11–8.76)</td><td>0.021</td><td>3.86 (1.16–12.79)</td><td>0.017</td></tr><tr><td>ACSL4</td><td>9</td><td>54</td><td>13</td><td>23</td><td>4.92 (2.09–11.62)</td><td>0</td><td>5.6 (2.19–14.32)</td><td>0</td><td>8</td><td>78</td><td>10</td><td>41</td><td>2.59 (1.02–6.57)</td><td>0.045</td><td>2.31 (0.85–6.27)</td><td>0.1</td></tr></table>
<table><tr><td rowspan="3">Variable</td><td colspan="8">Training group (n = 77)</td><td colspan="8">Validation group (n = 119)</td></tr><tr><td colspan="2">Low Risk</td><td colspan="2">High Risk</td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted#</td><td colspan="2">Low Risk</td><td colspan="2">High Risk</td><td colspan="2">Unadjusted</td><td colspan="2">Adjusted#</td></tr><tr><td>R</td><td>N</td><td>R</td><td>N</td><td>HR (95% CI)</td><td>P</td><td>HR (95% CI)</td><td>P</td><td>R</td><td>N</td><td>R</td><td>N</td><td>HR (95% CI)</td><td>P</td><td>HR (95% CI)</td><td>P</td></tr><tr><td>SCD</td><td>3</td><td>26</td><td>19</td><td>51</td><td>3.57 (1.06–12.08)</td><td>0.018</td><td>3.13 (0.9–10.93)</td><td>0.046</td><td>3</td><td>57</td><td>15</td><td>62</td><td>5.32 (1.54–18.38)</td><td>0.002</td><td>4.08 (1.12–14.9)</td><td>0.017</td></tr><tr><td>x3</td><td>6</td><td>46</td><td>16</td><td>31</td><td>5.36 (2.09–13.74)</td><td>0.000</td><td>4.99 (1.81–13.77)</td><td>0.001</td><td>2</td><td>58</td><td>16</td><td>61</td><td>9 (2.07–39.21)</td><td>0.0002</td><td>8.68 (1.9–39.66)</td><td>6E-04</td></tr></table>
dd755590298820a34059cb4d4b33b97936324e1aadef161a0867375f4354d1b2.png
complex
<table><tr><td colspan="3"><i>t</i>-statistic and <i>p</i>-values for correlation significance</td></tr><tr><td colspan="3"><i>t</i>-statistics</td></tr><tr><td></td><td>Sig</td><td>NN</td></tr><tr><td>Sig</td><td></td><td></td></tr><tr><td>NN</td><td>2.917</td><td></td></tr><tr><td>NNSig</td><td>2.969</td><td>0.052</td></tr><tr><td colspan="3"><i>p</i>-values</td></tr><tr><td></td><td>Sig</td><td>NN</td></tr><tr><td>Sig</td><td></td><td></td></tr><tr><td>NN</td><td>0.998</td><td></td></tr><tr><td>NNSig</td><td>0.998</td><td>0.521</td></tr></table>
<table><tr><td colspan="3">t-statistic and p-values for correlation significance</td></tr><tr><td colspan="3">t-statistics</td></tr><tr><td></td><td>Sig</td><td>NN</td></tr><tr><td>Sig</td><td></td><td></td></tr><tr><td>NN</td><td>2.917</td><td></td></tr><tr><td>NNSig</td><td>2.969</td><td>0.052</td></tr></table>
<table><tr><td colspan="3">p-values</td></tr><tr><td></td><td>Sig</td><td>NN</td></tr><tr><td>Sig</td><td></td><td></td></tr><tr><td>NN</td><td>0.998</td><td></td></tr><tr><td>NNSig</td><td>0.998</td><td>0.521</td></tr></table>
4397822c424a839277dcfc310bfaaf6455d7843a33ef0b93f96321ac19d384cd.png
simple
<table><tr><td>WTP</td><td>(% N)</td></tr><tr><td>0</td><td>40.5%</td></tr><tr><td>&lt; &#8364; 15,000</td><td>9.7%</td></tr><tr><td>= &#8364; 15,000</td><td>18.8%</td></tr><tr><td>&gt; &#8364; 15,000</td><td>16.9%</td></tr><tr><td>&gt; &#8364; 30,000</td><td>14.1%</td></tr><tr><td>Mean</td><td>&#8364; 13,764</td></tr><tr><td>Standard deviation</td><td>&#8364; 21,719</td></tr><tr><td>95% CI</td><td>&#8364;11,863 &#8211; &#8364;15,665</td></tr><tr><td>Minimum</td><td>0</td></tr><tr><td>Maximum</td><td>&#8364; 100,000</td></tr><tr><td>Percentiles</td><td></td></tr><tr><td>25</td><td>0</td></tr><tr><td>50</td><td>&#8364; 10,000</td></tr><tr><td>75</td><td>&#8364; 20,000</td></tr></table>
<table><tr><td>WTP</td><td>(% N)</td></tr><tr><td>0</td><td>40.5%</td></tr><tr><td>< € 15,000</td><td>9.7%</td></tr><tr><td>= € 15,000</td><td>18.8%</td></tr><tr><td>> € 15,000</td><td>16.9%</td></tr><tr><td>> € 30,000</td><td>14.1%</td></tr><tr><td>Mean</td><td>€ 13,764</td></tr><tr><td>Standard deviation</td><td>€ 21,719</td></tr></table>
<table><tr><td>95% CI</td><td>€11,863 – €15,665</td></tr><tr><td>Minimum</td><td>0</td></tr><tr><td>Maximum</td><td>€ 100,000</td></tr><tr><td>Percentiles</td><td></td></tr><tr><td>25</td><td>0</td></tr><tr><td>50</td><td>€ 10,000</td></tr><tr><td>75</td><td>€ 20,000</td></tr></table>
ccbab782a54c319646381b919f32038cafe34a55f9bf268840c62c089cf6e3ca.png
complex
<table><tr><td rowspan="2">Age, sex, and education</td><td colspan="3">Dhaka (urban)</td><td colspan="3">Matlab (rural)</td></tr><tr><td>COPD</td><td>Hypertension</td><td>Comorbidity</td><td>COPD</td><td>Hypertension</td><td>Comorbidity</td></tr><tr><td>Age</td><td rowspan="2">54.4 &#177; 15.1</td><td rowspan="2">55.5 &#177; 13.7</td><td rowspan="2">63.2 &#177; 10.2</td><td rowspan="2">63.6 &#177; 13.5</td><td rowspan="2">62.3 &#177; 11.9</td><td rowspan="2">68.9 &#177; 10.8</td></tr><tr><td> Mean &#177; std</td></tr><tr><td> Median</td><td>54.6</td><td>56.3</td><td>62.5</td><td>64.4</td><td>62.8</td><td>69.6</td></tr><tr><td> % of female patients</td><td>25.0</td><td>53.3</td><td>32.1</td><td>24.7</td><td>57.9</td><td>32.4</td></tr><tr><td>Level of education</td><td> </td><td> </td><td> </td><td> </td><td> </td><td> </td></tr><tr><td> % of none</td><td>46.2</td><td>22.0</td><td>35.8</td><td>43.5</td><td>29.3</td><td>41.9</td></tr><tr><td> % of primary (class I-V)</td><td>25.5</td><td>26.0</td><td>34.0</td><td>37.3</td><td>40.7</td><td>32.4</td></tr><tr><td> % of secondary + (class VI+)</td><td>28.2</td><td>52.0</td><td>30.2</td><td>19.2</td><td>30.0</td><td>25.7</td></tr><tr><td> No. of patients (N)</td><td>184</td><td>246</td><td>53</td><td>292</td><td>140</td><td>74</td></tr></table>
<table><tr><td rowspan="2">Age, sex, and education</td></tr><tr></tr><tr><td>Age</td></tr><tr><td>Mean ± std</td></tr><tr><td>Median</td></tr><tr><td>% of female patients</td></tr><tr><td>Level of education</td></tr><tr><td>% of none</td></tr><tr><td>% of primary (class I-V)</td></tr><tr><td>% of secondary + (class VI+)</td></tr><tr><td>No. of patients (N)</td></tr></table>
<table><tr><td colspan="3">Dhaka (urban)</td><td colspan="3">Matlab (rural)</td></tr><tr><td>COPD</td><td>Hypertension</td><td>Comorbidity</td><td>COPD</td><td>Hypertension</td><td>Comorbidity</td></tr><tr><td rowspan="2">54.4 ± 15.1</td><td rowspan="2">55.5 ± 13.7</td><td rowspan="2">63.2 ± 10.2</td><td rowspan="2">63.6 ± 13.5</td><td rowspan="2">62.3 ± 11.9</td><td rowspan="2">68.9 ± 10.8</td></tr><tr></tr><tr><td>54.6</td><td>56.3</td><td>62.5</td><td>64.4</td><td>62.8</td><td>69.6</td></tr><tr><td>25.0</td><td>53.3</td><td>32.1</td><td>24.7</td><td>57.9</td><td>32.4</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>46.2</td><td>22.0</td><td>35.8</td><td>43.5</td><td>29.3</td><td>41.9</td></tr><tr><td>25.5</td><td>26.0</td><td>34.0</td><td>37.3</td><td>40.7</td><td>32.4</td></tr><tr><td>28.2</td><td>52.0</td><td>30.2</td><td>19.2</td><td>30.0</td><td>25.7</td></tr><tr><td>184</td><td>246</td><td>53</td><td>292</td><td>140</td><td>74</td></tr></table>
8a313dcccc5ee259b4600a44304a3031b5c52157b524d3163f6eba9b08e47adf.png
simple
<table><tr><td>Generated Commands</td><td>Description</td></tr><tr><td>Start</td><td>SLAM and control algorithms begin</td></tr><tr><td>Stop</td><td>Stops robot's movements but the SLAM algorithm continues</td></tr><tr><td>Turn to the left</td><td>Sustained command to make the robot turning to user's left</td></tr><tr><td>Turn to the right</td><td>Sustained command to make the robot turning to user's right</td></tr><tr><td>Exit</td><td>SLAM stops and a map is visualized</td></tr></table>
<table><tr><td>Generated Commands</td><td>Description</td></tr></table>
<table><tr><td>Start</td><td>SLAM and control algorithms begin</td></tr><tr><td>Stop</td><td>Stops robot's movements but the SLAM algorithm continues</td></tr><tr><td>Turn to the left</td><td>Sustained command to make the robot turning to user's left</td></tr><tr><td>Turn to the right</td><td>Sustained command to make the robot turning to user's right</td></tr><tr><td>Exit</td><td>SLAM stops and a map is visualized</td></tr></table>