Datasets:

ClarusC64
/

ABX-CS-007_immunocompromised_host_response-v0.1

row_id string	series_id string	day int64	host_model string	abx_drug string	abx_exposure_index float64	severity_index float64	anc_10e9_L float64	expected_anc_10e9_L float64	anc_recovery_vs_expected float64	temp_c float64	expected_temp_c float64	temp_nonresponse_vs_expected float64	crp_mg_L int64	expected_crp_mg_L int64	crp_nonresponse_vs_expected int64	neutro_fever_coherence_index float64	later_icu_or_persistent_bacteremia_or_antifungal_escalation_flag int64	assay_method string	source_type string	neutropenic_response_coherence_failure_signal int64	earliest_neutropenic_response_coherence_failure int64	notes string
ABXCS007-TR-0001	S1	0	human_sim	cefepime	0.1	0.9	0.05	0.05	0	39.4	39.4	0	220	220	0	0.9	0	vitals_anc_crp_panel	simulated	0	0	baseline
ABXCS007-TR-0002	S1	1	human_sim	cefepime	0.9	0.9	0.1	0.08	0.02	38.8	38.8	0	190	190	0	0.86	0	vitals_anc_crp_panel	simulated	0	0	tracks expected
ABXCS007-TR-0003	S1	2	human_sim	cefepime	0.9	0.9	0.35	0.15	0.2	38.9	38	0.9	180	140	40	0.35	0	vitals_anc_crp_panel	simulated	0	0	first coherence loss
ABXCS007-TR-0004	S1	3	human_sim	cefepime	0.9	0.9	0.6	0.25	0.35	39	37.6	1.4	175	110	65	0.3	0	vitals_anc_crp_panel	simulated	1	1	onset
ABXCS007-TR-0005	S1	5	human_sim	cefepime	0.9	0.9	1.2	0.6	0.6	39.1	37.2	1.9	190	80	110	0.2	1	vitals_anc_crp_panel	simulated	1	0	later escalation
ABXCS007-TR-0006	S2	0	human_sim	piperacillin_tazobactam	0.1	0.8	0.05	0.05	0	39	39	0	200	200	0	0.9	0	vitals_anc_crp_panel	simulated	0	0	baseline
ABXCS007-TR-0007	S2	2	human_sim	piperacillin_tazobactam	0.9	0.8	0.3	0.18	0.12	37.8	37.8	0	120	120	0	0.84	0	vitals_anc_crp_panel	simulated	0	0	improves
ABXCS007-TR-0008	S2	4	human_sim	piperacillin_tazobactam	0.9	0.8	0.9	0.6	0.3	37	37	0	60	60	0	0.83	0	vitals_anc_crp_panel	simulated	0	0	resolves
ABXCS007-TR-0009	S3	0	human_sim	cefepime	0.9	0.9	0.05	0.05	0	39.2	39.2	0	220	220	0	0.9	1	vitals_anc_crp_panel	simulated	0	0	baseline only
ABXCS007-TR-0010	S4	3	human_sim	cefepime	0.3	0.9	0.6	0.25	0.35	39	37.6	1.4	175	110	65	0.3	1	vitals_anc_crp_panel	simulated	0	0	exposure low ignore

ABX-CS-007 Immunocompromised Host Response

Purpose

Detect neutropenic fever response failure when ANC recovery no longer predicts fever and inflammation resolution under adequate antibiotic exposure.

Core pattern

abx_exposure_index high
severity_index high
neutro_fever_coherence_index drops
anc_recovery_vs_expected positive
temp_nonresponse_vs_expected stays high
crp_nonresponse_vs_expected stays high
later_icu_or_persistent_bacteremia_or_antifungal_escalation_flag appears

Files

data/train.csv
data/test.csv
scorer.py

Schema

Each row is one timepoint in a within series neutropenic fever course.

Required columns

row_id
series_id
day
host_model
abx_drug
abx_exposure_index
severity_index
anc_10e9_L
expected_anc_10e9_L
anc_recovery_vs_expected
temp_c
expected_temp_c
temp_nonresponse_vs_expected
crp_mg_L
expected_crp_mg_L
crp_nonresponse_vs_expected
neutro_fever_coherence_index
later_icu_or_persistent_bacteremia_or_antifungal_escalation_flag
assay_method
source_type
neutropenic_response_coherence_failure_signal
earliest_neutropenic_response_coherence_failure

Labels

neutropenic_response_coherence_failure_signal
- 1 for rows at or after first confirmed failure onset
earliest_neutropenic_response_coherence_failure
- 1 only for the first onset row in that series

Scorer logic v0.1

Candidate onset

abx_exposure_index at least 0.80
severity_index at least 0.80
neutro_fever_coherence_index at most 0.40
anc_recovery_vs_expected at least 0.10
temp_nonresponse_vs_expected at least 0.8
crp_nonresponse_vs_expected at least 25
requires two consecutive points
ignores one point fever spike then snapback

Confirmation

later_icu_or_persistent_bacteremia_or_antifungal_escalation_flag equals 1 later in the series

Run

python scorer.py --path data/test.csv

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24.7 kB

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