Datasets:
row_id
string | series_id
string | treatment_day
int64 | host_model
string | drug
string | duration_exposure_index
float64 | wbc_k_uL
float64 | expected_wbc_k_uL
float64 | wbc_drop_vs_expected
float64 | anc_k_uL
float64 | expected_anc_k_uL
float64 | anc_drop_vs_expected
float64 | platelets_k_uL
int64 | expected_platelets_k_uL
int64 | plt_drop_vs_expected
int64 | heme_coherence_index
float64 | host_stress_index
float64 | later_severe_cytopenia_flag
int64 | assay_method
string | source_type
string | heme_tox_signal
int64 | earliest_heme_tox
int64 | notes
string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ABXHT009-TR-0001
|
S1
| 0
|
human_sim
|
linezolid
| 0.1
| 6.8
| 6.8
| 0
| 3.8
| 3.8
| 0
| 240
| 240
| 0
| 0.9
| 0.1
| 0
|
cbc_panel
|
simulated
| 0
| 0
|
baseline
|
ABXHT009-TR-0002
|
S1
| 7
|
human_sim
|
linezolid
| 0.85
| 6.6
| 6.6
| 0
| 3.7
| 3.7
| 0
| 235
| 235
| 0
| 0.88
| 0.9
| 0
|
cbc_panel
|
simulated
| 0
| 0
|
tracks expected
|
ABXHT009-TR-0003
|
S1
| 10
|
human_sim
|
linezolid
| 0.9
| 4.8
| 6.4
| 1.6
| 2.2
| 3.6
| 1.4
| 210
| 232
| 22
| 0.35
| 0.9
| 0
|
cbc_panel
|
simulated
| 0
| 0
|
first suppression drift
|
ABXHT009-TR-0004
|
S1
| 12
|
human_sim
|
linezolid
| 0.9
| 4.5
| 6.3
| 1.8
| 2
| 3.6
| 1.6
| 200
| 230
| 30
| 0.3
| 0.9
| 0
|
cbc_panel
|
simulated
| 1
| 1
|
onset
|
ABXHT009-TR-0005
|
S1
| 21
|
human_sim
|
linezolid
| 0.9
| 2.5
| 6
| 3.5
| 0.6
| 3.3
| 2.7
| 120
| 220
| 100
| 0.2
| 0.9
| 1
|
cbc_panel
|
simulated
| 1
| 0
|
severe later
|
ABXHT009-TR-0006
|
S2
| 0
|
human_sim
|
amoxicillin
| 0.1
| 6.9
| 6.9
| 0
| 3.9
| 3.9
| 0
| 245
| 245
| 0
| 0.9
| 0.1
| 0
|
cbc_panel
|
simulated
| 0
| 0
|
baseline
|
ABXHT009-TR-0007
|
S2
| 10
|
human_sim
|
amoxicillin
| 0.9
| 6.5
| 6.5
| 0
| 3.6
| 3.6
| 0
| 240
| 240
| 0
| 0.86
| 0.9
| 0
|
cbc_panel
|
simulated
| 0
| 0
|
stable
|
ABXHT009-TR-0008
|
S2
| 20
|
human_sim
|
amoxicillin
| 0.9
| 6.6
| 6.4
| -0.2
| 3.7
| 3.5
| -0.2
| 238
| 238
| 0
| 0.84
| 0.9
| 0
|
cbc_panel
|
simulated
| 0
| 0
|
stable
|
ABXHT009-TR-0009
|
S3
| 0
|
human_sim
|
linezolid
| 0.9
| 5
| 5
| 0
| 0.9
| 0.9
| 0
| 200
| 200
| 0
| 0.9
| 0.9
| 1
|
cbc_panel
|
simulated
| 0
| 0
|
baseline ANC low
|
ABXHT009-TR-0010
|
S4
| 12
|
human_sim
|
linezolid
| 0.9
| 4.5
| 6.3
| 1.8
| 2
| 3.6
| 1.6
| 200
| 230
| 30
| 0.3
| 0.3
| 1
|
cbc_panel
|
simulated
| 0
| 0
|
stress low
|
ABX-HT-009 Hematological Toxicity Warning
Purpose
Detect early bone marrow suppression when CBC markers stop tracking expected course before severe cytopenia events.
Core pattern
- host_stress_index high
- duration_exposure_index high
- heme_coherence_index drops
- anc_drop_vs_expected stays high
- later_severe_cytopenia_flag appears
Files
- data/train.csv
- data/test.csv
- scorer.py
Schema
Each row is one timepoint in a within series treatment course.
Required columns
- row_id
- series_id
- treatment_day
- host_model
- drug
- duration_exposure_index
- wbc_k_uL
- expected_wbc_k_uL
- wbc_drop_vs_expected
- anc_k_uL
- expected_anc_k_uL
- anc_drop_vs_expected
- platelets_k_uL
- expected_platelets_k_uL
- plt_drop_vs_expected
- heme_coherence_index
- host_stress_index
- later_severe_cytopenia_flag
- assay_method
- source_type
- heme_tox_signal
- earliest_heme_tox
Labels
heme_tox_signal
- 1 for rows at or after first confirmed suppression onset
earliest_heme_tox
- 1 only for the first onset row in that series
Scorer logic in v1
- exclude series with low baseline ANC
- candidate onset point
- host_stress_index at least 0.80
- duration_exposure_index at least 0.80
- heme_coherence_index at most 0.40
- anc_drop_vs_expected at least 1.2 for two consecutive points
- ignore one point lab error then rebound artifacts
- confirmation
- later_severe_cytopenia_flag equals 1 later in series
Evaluation
Run
- python scorer.py --path data/test.csv
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