id
string | protein_type
string | folding_variance
float64 | conformational_entropy
float64 | thermal_stability_ratio
float64 | aggregation_index
float64 | ph_stress_level
float64 | trajectory_coherence_score
float64 | stability_divergence_flag
int64 | degradation_horizon_hours
int64 | critical_structure_region
string | stabilization_strategy
string | notes
string | constraints
string | gold_check
string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AF-001
|
monoclonal_antibody
| 0.18
| 0.22
| 0.93
| 0.05
| 7.4
| 0.88
| 0
| 720
|
none
|
monitor only
|
Stable production batch
|
Under 300 words
|
coherence+risk+horizon
|
AF-002
|
enzyme
| 0.31
| 0.36
| 0.78
| 0.14
| 6.8
| 0.66
| 1
| 120
|
active_site
|
buffer adjust
|
Early drift
|
Under 300 words
|
coherence+risk+horizon
|
AF-003
|
cytokine
| 0.42
| 0.48
| 0.61
| 0.22
| 7.2
| 0.55
| 1
| 60
|
loop_region
|
stabilizing mutation
|
Functional loss rising
|
Under 300 words
|
coherence+risk+horizon
|
AF-004
|
antibody_fragment
| 0.24
| 0.28
| 0.85
| 0.09
| 7
| 0.79
| 0
| 340
|
hinge_region
|
temperature control
|
Stable trending
|
Under 300 words
|
coherence+risk+horizon
|
AF-005
|
synthetic_enzyme
| 0.51
| 0.57
| 0.49
| 0.33
| 6.5
| 0.44
| 1
| 24
|
core_domain
|
sequence redesign
|
Critical instability
|
Under 300 words
|
coherence+risk+horizon
|
AF-006
|
binding_protein
| 0.21
| 0.25
| 0.88
| 0.07
| 7.4
| 0.82
| 0
| 410
|
none
|
monitor only
|
Healthy
|
Under 300 words
|
coherence+risk+horizon
|
What this dataset tests
Whether predicted folding trajectories remain predictive of functional stability under stress conditions.
Structure alone is not enough. The path to structure must stay coherent with real-world stability.
When that relationship breaks therapeutic proteins fail in storage manufacturing or use.
Required outputs
trajectory_coherence_score
stability_divergence_flag
degradation_horizon_hours
critical_structure_region
stabilization_strategy
Use case
Antibody engineering enzyme therapeutics synthetic biology biomanufacturing
Detect functional decay before activity collapse.
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