id
stringclasses 6
values | condition_family
stringclasses 6
values | medication_set
stringclasses 6
values | baseline_coherence_metrics
stringclasses 6
values | post_combination_coherence_metrics
stringclasses 6
values | variance_shift
stringclasses 3
values | synchrony_shift
stringclasses 3
values | net_coherence_score
stringclasses 3
values | interpretation
stringclasses 6
values | notes
stringclasses 6
values | constraints
stringclasses 1
value | gold_checklist
stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|
CCP-001
|
diabetes
|
metformin + GLP1
|
High glucose variance; low activity鈥搒leep coupling
|
Lower glucose variance; improved sleep鈥揳ctivity coupling
|
Decrease
|
Increase
|
High
|
System-wide coherence gain
|
Upstream appetite and insulin effects align
|
Under 220 words.
|
baseline+post+score
|
CCP-002
|
heart_failure
|
ACEi + beta-blocker + diuretic
|
BP variability; exertional intolerance
|
BP stabilized; functional tolerance improved
|
Decrease
|
Increase
|
High
|
Coherent combination
|
Classic guideline synergy
|
Under 220 words.
|
baseline+post+score
|
CCP-003
|
autoimmune
|
steroid + NSAID
|
Low symptom score; high lab volatility
|
Symptoms quiet; lab variance increases
|
Increase
|
Decrease
|
Low
|
Cosmetic suppression
|
Fragility masked
|
Under 220 words.
|
baseline+post+score
|
CCP-004
|
psychiatric
|
SSRI + benzodiazepine
|
Anxiety spikes; sleep fragmented
|
Anxiety lower; sleep fragmented persists
|
Neutral
|
Neutral
|
Medium
|
Partial coherence
|
Symptom relief without system alignment
|
Under 220 words.
|
baseline+post+score
|
CCP-005
|
respiratory
|
ICS + LABA
|
Frequent wheeze; eosinophils high
|
Wheeze reduced; eosinophils lower
|
Decrease
|
Increase
|
High
|
Coherent airway control
|
Aligned inflammatory and functional effects
|
Under 220 words.
|
baseline+post+score
|
CCP-006
|
cardiac
|
antiarrhythmic + stimulant
|
HR variability unstable
|
Arrhythmia suppressed; autonomic volatility rises
|
Increase
|
Decrease
|
Low
|
Hidden antagonism
|
Control with systemic cost
|
Under 220 words.
|
baseline+post+score
|
What this dataset tests
Whether a drug combination
improves system-wide coherence
or merely suppresses symptoms.
Required outputs
- baseline coherence metrics
- post-combination coherence metrics
- variance and synchrony shifts
- net coherence score
- interpretation
Use case
Front layer of the Polypharmacy Coherence Matrix.
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