id stringclasses 8
values | drug_name stringclasses 8
values | condition_context stringclasses 8
values | pre_coupling_summary stringclasses 8
values | on_drug_coupling_summary stringclasses 8
values | post_drug_coupling_summary stringclasses 8
values | observation_window stringclasses 6
values | coupling_change_matrix stringclasses 8
values | newly_synchronized_pairs stringclasses 8
values | newly_desynchronized_pairs stringclasses 8
values | instability_flags stringclasses 8
values | net_coupling_integrity_score stringclasses 3
values | monitoring_targets stringclasses 8
values | notes stringclasses 8
values | constraints stringclasses 1
value | gold_checklist stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CCDM-001 | SSRI | depression | Sleep and mood tightly coupled; HRV tracks sleep | Mood improves while HRV remains low; sleep improves | Coupling returns toward baseline; GI effects resolve | 9 months | sleep–mood: weaken; sleep–HRV: weaken; mood–HRV: weaken | mood–sleep (improves) | sleep–HRV; mood–HRV | low autonomic recovery | Medium | HRV; sleep staging; GI motility | Neural gain with autonomic lag | Under 240 words. | matrix+pairs+flags+score |
CCDM-002 | steroid | autoimmune_flare | Pain tracks inflammation; glucose stable | Pain decouples from inflammation markers; glucose rises | Rebound pain with persistent metabolic shift | 6 months | immune–pain: distort; immune–glucose: new coupling; sleep–glucose: strengthen | immune–glucose | immune–pain | metabolic drift; rebound risk | Low | glucose; sleep; infection markers | Suppression creates distortion | Under 240 words. | matrix+pairs+flags+score |
CCDM-003 | metformin | type2_diabetes | Glucose variance tracks sleep and activity | Glucose variance drops; GI upset decouples activity from appetite | GI resolves; glucose-sleep coupling strengthens | 12 months | glucose–sleep: strengthen; glucose–activity: strengthen; gut–appetite: transient strengthen | glucose–sleep; glucose–activity | activity–appetite | transient GI destabilization | High | sleep; activity; GI symptoms | Net coupling improvement | Under 240 words. | matrix+pairs+flags+score |
CCDM-004 | beta_blocker | arrhythmia | Anxiety spikes track palpitations; HRV low | Palpitations reduce; fatigue rises; activity decouples from mood | Fatigue resolves; palpitations return | 8 months | palpitations–anxiety: weaken; activity–mood: weaken; HRV–fatigue: strengthen | fatigue–HRV | activity–mood | functional suppression | Medium | activity; fatigue; HRV | Control with functional cost | Under 240 words. | matrix+pairs+flags+score |
CCDM-005 | GLP1 | obesity | Appetite and glucose tightly coupled | Appetite suppressed; nausea couples intake to dehydration risk | Nausea resolves; appetite–glucose coupling resets | 10 months | appetite–glucose: reset; nausea–hydration: strengthen; sleep–appetite: strengthen | sleep–appetite | appetite–glucose (old pattern) | dehydration sensitivity | Medium | hydration; renal labs; nausea | Conditional coupling shifts | Under 240 words. | matrix+pairs+flags+score |
CCDM-006 | benzodiazepine | anxiety | Anxiety and sleep weakly coupled; daytime function variable | Sleep improves but daytime function drops; missed dose triggers rebound anxiety | Rebound couples anxiety to sleep collapse | 7 months | sleep–anxiety: distort; dose–function: strengthen; anxiety–sleep: strengthen (rebound) | dose–function | sleep–restoration | dependence; rebound cascade | Low | adherence; rebound severity; falls risk | Fragility signature in coupling | Under 240 words. | matrix+pairs+flags+score |
CCDM-007 | stimulant | adhd | Focus and sleep inversely coupled | Focus up; sleep fragmentation rises; appetite drops | Sleep recovers; focus baseline returns | 6 months | focus–sleep: strengthen inverse; sleep–mood: weaken; appetite–sleep: weaken | focus–sleep (inverse) | sleep–mood | sleep debt drift | Medium | sleep; mood; appetite | Tradeoff coupling | Under 240 words. | matrix+pairs+flags+score |
CCDM-008 | diuretic | heart_failure | Weight and edema track symptoms | Edema down; renal markers become sensitive to intake | Stabilizes with titration | 9 months | volume–renal: strengthen; symptoms–weight: weaken; BP–renal: strengthen | volume–renal; BP–renal | symptoms–weight | AKI sensitivity | Medium | creatinine; electrolytes; intake | Narrowed operating range | Under 240 words. | matrix+pairs+flags+score |
What this dataset tests
How a single drug
changes coupling between systems.
Required outputs
- coupling change matrix
- newly synchronized pairs
- newly desynchronized pairs
- instability flags
- net coupling integrity score
- monitoring targets
Use case
Second layer of the Drug-Induced System Drift Library.
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