| id,pair_id,domain_a,domain_b,domain_a_phase_map,domain_b_phase_map,domain_a_failure_modes,domain_b_failure_modes,invariant_alignment_map,mismatch_flags,alignment_coherence_score_0_100,alignment_evidence,constraints,gold_checklist | |
| ISAM-001,"P-01","wound healing cascade","psychological trauma recovery","phase1 hemostasis minutes-hours; phase2 inflammation days; phase3 proliferation days-weeks; phase4 remodeling weeks-months","phase1 shock minutes-days; phase2 acute arousal days-weeks; phase3 meaning-making weeks-months; phase4 integration months-years","chronic inflammation; infection; hypertrophic scar; fibrosis","hyperarousal persistence; avoidance; intrusive memory; chronic dysregulation","A1 hemostasis aligns with B1 shock as immediate containment; A2 inflammation aligns with B2 arousal as mobilized defense; A3 proliferation aligns with B3 meaning-making as repair building; A4 remodeling aligns with B4 integration as long-term reorganization","mismatch if B2 lacks clear biomarker proxy; social context adds external drivers not present in A","86","Both are phase-ordered repair systems with early containment, mobilized defense, rebuilding, and long reorganization. Failure modes cluster as stuck activation and maladaptive remodeling.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-002,"P-02","fibrosis prevention in tissue repair","post-trauma psychological scarring prevention","phase1 injury signaling; phase2 inflammatory amplification; phase3 fibroblast activation; phase4 matrix remodeling","phase1 threat encoding; phase2 arousal amplification; phase3 consolidation of narratives; phase4 long-term memory remodeling","excess TGF-beta signaling; myofibroblast persistence; stiff ECM","overconsolidation of threat; rigid identity narrative; persistent avoidance loops","A2 amplification aligns with B2 amplification; A3 fibroblast persistence aligns with B3 rigid consolidation; A4 matrix remodeling aligns with B4 memory remodeling","mismatch if B has no single pathway analogue; ethical limits on intervention differ","82","Both contain a risk of repair overshoot that hardens the system. The invariant is persistent activation that converts adaptive repair into rigid structure.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-003,"P-03","sepsis trajectory stabilization","delirium prevention and recovery","phase1 infection trigger; phase2 systemic inflammation; phase3 organ support and recovery; phase4 immune reset","phase1 precipitant trigger; phase2 global dysregulation; phase3 stabilization and reorientation; phase4 cognitive reintegration","cytokine storm; microcirculatory failure; multi-organ dysfunction","sleep-wake disruption; neurotransmitter imbalance; sensory overload; prolonged cognitive decline","A2 systemic inflammation aligns with B2 global dysregulation; A3 organ support aligns with B3 stabilization scaffolding; A4 immune reset aligns with B4 reintegration","mismatch if B2 has multiple competing mechanisms; measurement noise in B higher","78","Both show a tipping phase where multi-stream signals diverge. Stabilization depends on restoring coherent coupling rather than fixing one number.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-004,"P-04","bone fracture repair","rehabilitation after major depression episode","phase1 hematoma; phase2 inflammation; phase3 callus formation; phase4 remodeling","phase1 collapse; phase2 acute symptom peak; phase3 function scaffolding; phase4 identity and habit remodeling","nonunion; malunion; chronic pain","relapse; anhedonia persistence; functional collapse; social withdrawal","A1 hematoma aligns with B1 collapse as forced reset; A3 callus aligns with B3 scaffolding as temporary structure; A4 remodeling aligns with B4 long remodeling","mismatch if B relapse loops occur without clear structural injury analogue","74","Both require temporary scaffolds that later get remodeled. Failure appears as stalled consolidation or unstable remodeling.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-005,"P-05","asthma exacerbation control","panic attack cycle stabilization","phase1 trigger exposure; phase2 bronchospasm cascade; phase3 rescue intervention; phase4 airway recovery","phase1 trigger cue; phase2 arousal cascade; phase3 grounding intervention; phase4 nervous system recovery","status asthmaticus; steroid overuse; rebound inflammation","fear of fear loop; avoidance reinforcement; sensitization","A2 bronchospasm cascade aligns with B2 arousal cascade; A3 rescue aligns with B3 grounding; A4 recovery aligns with B4 settling","mismatch if B triggers are internal and self-generated while A often external","80","Both are fast positive-feedback loops with a rescue window. The invariant is interrupting amplification early and preventing sensitization.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-006,"P-06","gut microbiome recovery after antibiotics","sleep cycle restoration after burnout","phase1 disruption; phase2 instability; phase3 recolonization; phase4 stabilization","phase1 disruption; phase2 dysregulation; phase3 re-entrainment; phase4 stabilization","dysbiosis persistence; opportunist overgrowth; inflammation","insomnia persistence; hypervigilance; circadian drift","A3 recolonization aligns with B3 re-entrainment as rebuilding a stable attractor; A4 stabilization aligns with B4 stabilization","mismatch if B has intentional control loops and A has ecological constraints","72","Both recover by re-establishing a stable ecosystem rhythm. Failure is drift into a maladaptive attractor.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-007,"P-07","chemotherapy marrow suppression and recovery","post-viral fatigue recovery pattern","phase1 insult; phase2 nadir; phase3 rebound; phase4 stabilization","phase1 insult; phase2 crash; phase3 rebound; phase4 stabilization","infection risk; delayed recovery; relapse","post-exertional malaise; oscillation; prolonged dysregulation","A2 nadir aligns with B2 crash; A3 rebound aligns with B3 rebound; A4 stabilization aligns with B4 stabilization","mismatch if B has unclear biomarkers for phase boundary detection","70","Both show predictable phase order and a vulnerability window around the nadir. The invariant is pacing and support through rebound without overshoot.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-008,"P-08","chronic pain central sensitization","chronic anxiety sensitization loop","phase1 injury; phase2 nociceptive amplification; phase3 central sensitization; phase4 chronic maintenance","phase1 stressor; phase2 arousal amplification; phase3 threat sensitization; phase4 chronic maintenance","allodynia; pain spread; opioid dependence","hypervigilance; avoidance; reassurance seeking reinforcement","A3 central sensitization aligns with B3 threat sensitization; both maintain through prediction error biasing toward threat/pain","mismatch if A has peripheral drivers that persist while B often has none","84","Both convert transient signals into persistent prediction loops. The invariant is learning-based amplification and maintenance.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-009,"P-09","immune tolerance induction in allergy","exposure therapy in phobia","phase1 sensitization; phase2 exposure dosing; phase3 tolerance building; phase4 maintenance","phase1 sensitization; phase2 graded exposure; phase3 extinction learning; phase4 maintenance","anaphylaxis risk; rebound sensitivity","dropout; context specificity; return of fear","A2 graded dosing aligns with B2 graded exposure; A3 tolerance aligns with B3 extinction learning; A4 maintenance aligns with B4 maintenance","mismatch if immune tolerance can be durable while fear extinction is context-bound","76","Both aim to recalibrate a reactive system through graded exposure. Failure modes track as overshoot risk and relapse risk.","Under 260 words.","has phase maps+alignment+mismatch+score" | |
| ISAM-010,"P-10","stroke rehab motor relearning","language reacquisition after aphasia","phase1 acute injury; phase2 early rehab; phase3 neuroplastic relearning; phase4 consolidation","phase1 acute injury; phase2 early speech therapy; phase3 relearning; phase4 consolidation","learned nonuse; spasticity; plateau misread","learned nonuse; compensatory shortcuts; plateau misread","A3 relearning aligns with B3 relearning; plateau meaning is shared: either consolidation or stalled adaptation","mismatch if language has higher social constraint and feedback than motor tasks","79","Both are plasticity-driven relearning systems. The invariant is interpreting plateaus correctly and preventing maladaptive compensation.","Under 260 words.","has phase maps+alignment+mismatch+score" | |