id stringclasses 10 values | pair_id stringclasses 10 values | domain_a stringclasses 10 values | domain_b stringclasses 10 values | domain_a_phase_map stringclasses 10 values | domain_b_phase_map stringclasses 10 values | domain_a_failure_modes stringclasses 10 values | domain_b_failure_modes stringclasses 10 values | invariant_alignment_map stringclasses 10 values | mismatch_flags stringclasses 10 values | alignment_coherence_score_0_100 int64 70 86 | alignment_evidence stringclasses 10 values | constraints stringclasses 1 value | gold_checklist stringclasses 1 value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ISAM-001 | P-01 | wound healing cascade | psychological trauma recovery | phase1 hemostasis minutes-hours; phase2 inflammation days; phase3 proliferation days-weeks; phase4 remodeling weeks-months | phase1 shock minutes-days; phase2 acute arousal days-weeks; phase3 meaning-making weeks-months; phase4 integration months-years | chronic inflammation; infection; hypertrophic scar; fibrosis | hyperarousal persistence; avoidance; intrusive memory; chronic dysregulation | A1 hemostasis aligns with B1 shock as immediate containment; A2 inflammation aligns with B2 arousal as mobilized defense; A3 proliferation aligns with B3 meaning-making as repair building; A4 remodeling aligns with B4 integration as long-term reorganization | mismatch if B2 lacks clear biomarker proxy; social context adds external drivers not present in A | 86 | Both are phase-ordered repair systems with early containment, mobilized defense, rebuilding, and long reorganization. Failure modes cluster as stuck activation and maladaptive remodeling. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-002 | P-02 | fibrosis prevention in tissue repair | post-trauma psychological scarring prevention | phase1 injury signaling; phase2 inflammatory amplification; phase3 fibroblast activation; phase4 matrix remodeling | phase1 threat encoding; phase2 arousal amplification; phase3 consolidation of narratives; phase4 long-term memory remodeling | excess TGF-beta signaling; myofibroblast persistence; stiff ECM | overconsolidation of threat; rigid identity narrative; persistent avoidance loops | A2 amplification aligns with B2 amplification; A3 fibroblast persistence aligns with B3 rigid consolidation; A4 matrix remodeling aligns with B4 memory remodeling | mismatch if B has no single pathway analogue; ethical limits on intervention differ | 82 | Both contain a risk of repair overshoot that hardens the system. The invariant is persistent activation that converts adaptive repair into rigid structure. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-003 | P-03 | sepsis trajectory stabilization | delirium prevention and recovery | phase1 infection trigger; phase2 systemic inflammation; phase3 organ support and recovery; phase4 immune reset | phase1 precipitant trigger; phase2 global dysregulation; phase3 stabilization and reorientation; phase4 cognitive reintegration | cytokine storm; microcirculatory failure; multi-organ dysfunction | sleep-wake disruption; neurotransmitter imbalance; sensory overload; prolonged cognitive decline | A2 systemic inflammation aligns with B2 global dysregulation; A3 organ support aligns with B3 stabilization scaffolding; A4 immune reset aligns with B4 reintegration | mismatch if B2 has multiple competing mechanisms; measurement noise in B higher | 78 | Both show a tipping phase where multi-stream signals diverge. Stabilization depends on restoring coherent coupling rather than fixing one number. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-004 | P-04 | bone fracture repair | rehabilitation after major depression episode | phase1 hematoma; phase2 inflammation; phase3 callus formation; phase4 remodeling | phase1 collapse; phase2 acute symptom peak; phase3 function scaffolding; phase4 identity and habit remodeling | nonunion; malunion; chronic pain | relapse; anhedonia persistence; functional collapse; social withdrawal | A1 hematoma aligns with B1 collapse as forced reset; A3 callus aligns with B3 scaffolding as temporary structure; A4 remodeling aligns with B4 long remodeling | mismatch if B relapse loops occur without clear structural injury analogue | 74 | Both require temporary scaffolds that later get remodeled. Failure appears as stalled consolidation or unstable remodeling. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-005 | P-05 | asthma exacerbation control | panic attack cycle stabilization | phase1 trigger exposure; phase2 bronchospasm cascade; phase3 rescue intervention; phase4 airway recovery | phase1 trigger cue; phase2 arousal cascade; phase3 grounding intervention; phase4 nervous system recovery | status asthmaticus; steroid overuse; rebound inflammation | fear of fear loop; avoidance reinforcement; sensitization | A2 bronchospasm cascade aligns with B2 arousal cascade; A3 rescue aligns with B3 grounding; A4 recovery aligns with B4 settling | mismatch if B triggers are internal and self-generated while A often external | 80 | Both are fast positive-feedback loops with a rescue window. The invariant is interrupting amplification early and preventing sensitization. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-006 | P-06 | gut microbiome recovery after antibiotics | sleep cycle restoration after burnout | phase1 disruption; phase2 instability; phase3 recolonization; phase4 stabilization | phase1 disruption; phase2 dysregulation; phase3 re-entrainment; phase4 stabilization | dysbiosis persistence; opportunist overgrowth; inflammation | insomnia persistence; hypervigilance; circadian drift | A3 recolonization aligns with B3 re-entrainment as rebuilding a stable attractor; A4 stabilization aligns with B4 stabilization | mismatch if B has intentional control loops and A has ecological constraints | 72 | Both recover by re-establishing a stable ecosystem rhythm. Failure is drift into a maladaptive attractor. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-007 | P-07 | chemotherapy marrow suppression and recovery | post-viral fatigue recovery pattern | phase1 insult; phase2 nadir; phase3 rebound; phase4 stabilization | phase1 insult; phase2 crash; phase3 rebound; phase4 stabilization | infection risk; delayed recovery; relapse | post-exertional malaise; oscillation; prolonged dysregulation | A2 nadir aligns with B2 crash; A3 rebound aligns with B3 rebound; A4 stabilization aligns with B4 stabilization | mismatch if B has unclear biomarkers for phase boundary detection | 70 | Both show predictable phase order and a vulnerability window around the nadir. The invariant is pacing and support through rebound without overshoot. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-008 | P-08 | chronic pain central sensitization | chronic anxiety sensitization loop | phase1 injury; phase2 nociceptive amplification; phase3 central sensitization; phase4 chronic maintenance | phase1 stressor; phase2 arousal amplification; phase3 threat sensitization; phase4 chronic maintenance | allodynia; pain spread; opioid dependence | hypervigilance; avoidance; reassurance seeking reinforcement | A3 central sensitization aligns with B3 threat sensitization; both maintain through prediction error biasing toward threat/pain | mismatch if A has peripheral drivers that persist while B often has none | 84 | Both convert transient signals into persistent prediction loops. The invariant is learning-based amplification and maintenance. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-009 | P-09 | immune tolerance induction in allergy | exposure therapy in phobia | phase1 sensitization; phase2 exposure dosing; phase3 tolerance building; phase4 maintenance | phase1 sensitization; phase2 graded exposure; phase3 extinction learning; phase4 maintenance | anaphylaxis risk; rebound sensitivity | dropout; context specificity; return of fear | A2 graded dosing aligns with B2 graded exposure; A3 tolerance aligns with B3 extinction learning; A4 maintenance aligns with B4 maintenance | mismatch if immune tolerance can be durable while fear extinction is context-bound | 76 | Both aim to recalibrate a reactive system through graded exposure. Failure modes track as overshoot risk and relapse risk. | Under 260 words. | has phase maps+alignment+mismatch+score |
ISAM-010 | P-10 | stroke rehab motor relearning | language reacquisition after aphasia | phase1 acute injury; phase2 early rehab; phase3 neuroplastic relearning; phase4 consolidation | phase1 acute injury; phase2 early speech therapy; phase3 relearning; phase4 consolidation | learned nonuse; spasticity; plateau misread | learned nonuse; compensatory shortcuts; plateau misread | A3 relearning aligns with B3 relearning; plateau meaning is shared: either consolidation or stalled adaptation | mismatch if language has higher social constraint and feedback than motor tasks | 79 | Both are plasticity-driven relearning systems. The invariant is interpreting plateaus correctly and preventing maladaptive compensation. | Under 260 words. | has phase maps+alignment+mismatch+score |
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