Datasets:

ClarusC64
/

endpoint-framework-transition-integrity-v0.1

sample_id string	source_framework string	target_framework string	concept string	source_definition string	target_definition string	claim string	option_a string	option_b string	task string	correct_option string	required_note string	required_keywords string	axis string	difficulty int64
CEFT-0001	Protocol	Publication	Primary endpoint	PFS per RECIST 1.1	OS at 12 months	Report OS as primary efficacy	Invalid correspondence, endpoint changed	Valid correspondence, same efficacy goal	Judge correspondence and write note	A	State PFS vs OS shift and flag endpoint substitution	PFS\|OS\|endpoint shift\|protocol\|publication	endpoint_identity	3
CEFT-0002	Protocol	Publication	Primary endpoint	Time to progression	PFS	Treat as same endpoint	Partial correspondence, definitions differ	Valid correspondence, equivalent metrics	Judge correspondence and write note	A	State TTP vs PFS difference and define event rules	TTP\|PFS\|event rule\|difference\|define	endpoint_definition	2
CEFT-0003	Protocol	SAP	Primary endpoint	ORR confirmed	ORR unconfirmed	Assume confirmation unchanged	Invalid correspondence, responder rule changed	Valid correspondence, same ORR	Judge correspondence and write note	A	State confirmed vs unconfirmed ORR and flag drift	confirmed\|unconfirmed\|ORR\|responder\|drift	responder_rule	2
CEFT-0004	SAP	Publication	Primary endpoint	PFS from randomization	PFS from first dose	Treat as same time origin	Partial correspondence, time origin differs	Valid correspondence, PFS label matches	Judge correspondence and write note	A	State randomization vs first dose and specify time zero	randomization\|first dose\|time zero\|PFS\|specify	time_origin	2
CEFT-0005	Protocol	Publication	Secondary endpoint	QoL mean change	QoL responder rate	Report as same patient benefit	Invalid correspondence, scale changed	Partial correspondence, map with transform	Judge correspondence and write note	A	State mean change vs responder rate and flag scale shift	mean change\|responder rate\|QoL\|scale\|shift	endpoint_scale	3
CEFT-0006	Protocol	Publication	Composite endpoint	MACE includes hospitalization	MACE excludes hospitalization	Treat composite as unchanged	Invalid correspondence, component removed	Partial correspondence, restate components	Judge correspondence and write note	A	State hospitalization component change and flag drift	MACE\|hospitalization\|component\|change\|drift	composite_components	3
CEFT-0007	Protocol	SAP	Endpoint hierarchy	Primary OS, secondary PFS	Co-primary OS and PFS	Assume hierarchy unchanged	Invalid correspondence, hierarchy altered	Valid correspondence, justified change	Judge correspondence and write note	A	State hierarchy change and require justification	primary\|secondary\|co-primary\|hierarchy\|justify	endpoint_hierarchy	3
CEFT-0008	Protocol	Publication	Endpoint window	12-month OS	24-month OS	Pool survival outcomes	Partial correspondence, window differs	Valid correspondence, same endpoint	Judge correspondence and write note	A	State 12 vs 24 month window and flag mismatch	12 month\|24 month\|window\|OS\|mismatch	window_definition	2
CEFT-0009	Protocol	Publication	Exploratory endpoint	Biomarker response exploratory	Biomarker response efficacy claim	Treat exploratory as confirmatory	Invalid correspondence, role escalation	Valid correspondence, exploratory retained	Judge correspondence and write note	A	State exploratory to efficacy shift and flag escalation	exploratory\|efficacy\|biomarker\|escalation\|drift	endpoint_role	3
CEFT-0010	Protocol	Publication	Non-inferiority margin	NI margin HR 1.25	NI margin HR 1.10	Report same NI conclusion	Invalid correspondence, margin changed	Partial correspondence, restate margin	Judge correspondence and write note	A	State margin change and flag decision shift	NI margin\|1.25\|1.10\|decision\|shift	decision_threshold	3