uid stringclasses 10
values | dataset_id stringclasses 1
value | year int64 2.02k 2.02k | therapeutic_area stringclasses 6
values | biomarker stringclasses 10
values | biomarker_role stringclasses 5
values | causal_pathway_alignment stringclasses 3
values | predicts_outcome stringclasses 3
values | dose_response_alignment stringclasses 2
values | reproducibility stringclasses 2
values | human_measurable stringclasses 2
values | prospective_use stringclasses 2
values | sponsor_summary stringclasses 10
values | question stringclasses 1
value | ground_truth_label stringclasses 2
values | ground_truth_rationale stringclasses 10
values | outcome_signal stringclasses 6
values | source_citation stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TB-TR-001 | pharma-translational-biomarker-validity-v0.1 | 2,024 | Oncology | PDL1_expression | predictive | high | yes | yes | yes | yes | yes | Biomarker prospectively stratifies patients and tracks response. | Is biomarker validity coherent. Answer coherent or incoherent. | coherent | Causal pathway and predictive value established. | trial_enrichment_success | Synthetic |
TB-TR-002 | pharma-translational-biomarker-validity-v0.1 | 2,024 | Oncology | Marker_X | correlative | low | no | no | no | yes | no | Marker elevated in responders but not predictive or causal. | Is biomarker validity coherent. Answer coherent or incoherent. | incoherent | Correlation without causation or predictive value. | biomarker_failure_risk | Synthetic |
TB-TR-003 | pharma-translational-biomarker-validity-v0.1 | 2,023 | Cardiology | LDL_C | causal | high | yes | yes | yes | yes | yes | LDL reduction linked to event reduction and used prospectively. | Is biomarker validity coherent. Answer coherent or incoherent. | coherent | Causal biomarker with outcome link. | high_confidence_marker | Synthetic |
TB-TR-004 | pharma-translational-biomarker-validity-v0.1 | 2,023 | Cardiology | Inflammation_marker | correlative | medium | no | no | no | yes | no | Marker fluctuates without consistent outcome prediction. | Is biomarker validity coherent. Answer coherent or incoherent. | incoherent | Inconsistent predictive value. | weak_marker | Synthetic |
TB-TR-005 | pharma-translational-biomarker-validity-v0.1 | 2,022 | Neurology | CSF_tau | surrogate | medium | partial | yes | yes | yes | yes | Tau changes align partially with cognitive measures. | Is biomarker validity coherent. Answer coherent or incoherent. | coherent | Partial but consistent predictive value. | moderate_confidence | Synthetic |
TB-TR-006 | pharma-translational-biomarker-validity-v0.1 | 2,022 | Neurology | Marker_Y | correlative | low | no | no | no | no | no | Marker only seen in animals; not measurable in clinic. | Is biomarker validity coherent. Answer coherent or incoherent. | incoherent | Not translatable to humans. | translation_failure_risk | Synthetic |
TB-TR-007 | pharma-translational-biomarker-validity-v0.1 | 2,021 | Rheumatology | CRP | activity_marker | high | yes | yes | yes | yes | yes | CRP tracks inflammation and response across doses. | Is biomarker validity coherent. Answer coherent or incoherent. | coherent | Strong activity marker with outcome link. | high_confidence_marker | Synthetic |
TB-TR-008 | pharma-translational-biomarker-validity-v0.1 | 2,021 | Rheumatology | Marker_Z | correlative | low | no | no | no | yes | no | Marker varies widely and not linked to response. | Is biomarker validity coherent. Answer coherent or incoherent. | incoherent | No predictive or causal role. | weak_marker | Synthetic |
TB-TR-009 | pharma-translational-biomarker-validity-v0.1 | 2,020 | Infectious Disease | viral_load | causal | high | yes | yes | yes | yes | yes | Load reduction predicts recovery and tracks dose. | Is biomarker validity coherent. Answer coherent or incoherent. | coherent | Direct causal link. | high_confidence_marker | Synthetic |
TB-TR-010 | pharma-translational-biomarker-validity-v0.1 | 2,020 | Metabolic Disease | Marker_Q | correlative | medium | no | no | no | yes | no | Marker changes but glucose control unaffected. | Is biomarker validity coherent. Answer coherent or incoherent. | incoherent | Marker not predictive of outcome. | biomarker_failure_risk | Synthetic |
What this repo is for
decide if a biomarker is worth using as a decision driver
stop teams using biomarkers that only correlate
prevent false confidence in early trials
choose enrichment markers for patient selection
choose activity markers for dose finding
reduce wasted phase 2 and phase 3 spend
What the model must do
You give it one row.
It must output one label.
coherent
incoherent
How to interpret the label
coherent means
biomarker sits on the causal chain
biomarker predicts outcome
biomarker tracks dose
biomarker repeats across studies
biomarker is measurable in humans
biomarker used prospectively
incoherent means
biomarker correlates only
biomarker moves but outcome does not
outcome moves but biomarker does not
biomarker picked after results
biomarker not measurable in humans
narrative overclaims
Example prompt format
Input Sponsor summary plus fields.
Output coherent
or incoherent
Add this short line too
Who uses this
translational medicine
clinical pharmacology
biomarker leads
portfolio committees
due diligence teams
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