task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2ccc(OC(C)C)cc2)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1noc([C@H](NC(=O)Nc2ccc(Oc3cccnc3)nc2)C(C)C)n1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1c(=O)c2c(nc(NCc3ccccc3)n2CC(N)=O)n(C)c1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? CC[C@@H](COC)NC(=O)C(=O)Nc1ccc2c(c1)nc(C(C)(C)C)n2C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1cc2n(n1)CC[NH+](C1CCCCC1)C2)C1[C@H]2C[NH2+]C[C@@H]12 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH]1cc(c2c1cccc2)-c1nnc(SCC(Nc2c(c(ccc2)C)C)=O)o1 ### Response: Cc1cccc(NC(=O)CSc2nnc(-c3c[nH]c4ccccc34)o2)c1C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1CCC[C@H](c1ccccc1)O)OC ### Response: COc1ccc(CCC[C@@H](O)c2ccccc2)cc1
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1cccn2cc(-c3ccc(NC(=O)C(=O)NCc4cccs4)cc3)nc12 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CC2(SC1)CCCCC2)C(Nc1nc2c(COCC2)s1)=O ### Response: O=C(Nc1nc2c(s1)COCC2)N1CCSC2(CCCCC2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [4*]Cc1cccnc1 ### Response: CN(Cc1cccnc1)C(=O)NCC1(c2ccc(F)cc2F)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC[C@H](NC(=O)NCc1ccc(OC)c(O)c1)c1ccc(F)c(F)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)c(OC)c1 Fragment 2: [5*]NCC[8*] ### Response: COc1ccc(CCNC(=O)c2c[nH]c3c(c(C)nn3-c3ccccc3)c2=O)cc1OC
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccn2c(=O)c(/C=N/NC(=O)c3ccncc3)c(N3CCCC3)nc12 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCO[3*] Fragment 2: [9*]n1nnnc1[14*] ### Response: Cc1cccc(OCCC(=O)Nc2ccc(-c3nnnn3C3CC3)cc2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1C(=O)Nc2cc(C(=O)N(C)Cc3ccccc3Cl)ccc2N1C ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(C(=O)c1cc(C(C)C)n(C(C)(C)C)n1)c1ccc(C#N)c(Cl)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(Cc1ccc(Br)o1)C(=O)c1nc(C(C)(C)C)n[nH]1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a carboxyl group? C=CCC[C@@H](C)[NH+](C)Cc1cnn(-c2ccccc2)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2ncc(C(=O)Nc3cc(OC)ccc3F)s2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N[C@H](C(C)(C)C)C)c1ccnc(OC2CCC2)c1 ### Response: C[C@H](NC(=O)c1ccnc(OC2CCC2)c1)C(C)(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[NH+](C1)CCCNC(=O)[C@H](Oc1cccc(C)c1)C ### Response: Cc1cccc(O[C@H](C)C(=O)NCCC[NH+]2CCCC2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)[C@@]([4*])(OC)C(F)(F)F ### Response: CCOC(=O)[C@@](NC(=O)Nc1cccc(C)n1)(OC)C(F)(F)F
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccncc1NC(=O)/C=C/c1ccc(-c2ccccc2)s1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CCC[NH+](C)C1 Fragment 2: [5*]NCC=C ### Response: C=CCNC(=O)[C@@H]1CCC[NH+](C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1cccs1 Fragment 2: [5*]N([5*])c1nc2ccc(OC)cc2s1 ### Response: COc1ccc2nc(N(C[C@H]3CCCO3)C(=O)/C=C/c3cccs3)sc2c1
functional_group
### Instruction: Does the molecule contain a ether group? CCNC(=O)/C(=C/c1cccc(OC)c1)n1nnnc1C ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=S(=O)(c1ccccc1)C1[C@@H]2CCC[C@H]1C2Cl ### Response: 2
functional_group
### Instruction: Does the molecule contain a aldehyde group? O=Cc1ccc2c3c(cccc13)-c1ccccc1-2 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccco1 Fragment 2: [1*]C(=O)c1cccc2ccccc12 ### Response: O=C(c1cccc2ccccc12)N(Cc1ccco1)[C@@H]1CCS(=O)(=O)C1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H]1CCCCC[NH+]1CC(C)(C)[C@@H](C)[NH3+] ### Response: No
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCN(C(=O)Cn1nc2n(c1=O)CCCCC2)[C@H]1CCS(=O)(=O)C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CC([C@H](C#N)c2ncccc2)=O)c2ccc(cc2OCC1=O)Br ### Response: N#C[C@@H](C(=O)CN1C(=O)COc2cc(Br)ccc21)c1ccccn1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc2ncn(C[C@H]3CC3(Cl)Cl)c2cc1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CCC[NH+]1CCC(NC(=O)NC[C@H]2CC[C@H](C(=O)N(C)C)O2)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC1=N[C@@H]([N+](=O)[O-])[C@@H](Sc2nc3ccc([N+](=O)[O-])cc3[nH]2)N1Cc1ccccc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(C)cc1 Fragment 2: [1*]C(=O)C[4*] ### Response: COC(=O)[C@H]1C([O-])=NC(SCC(=O)Nc2ccc3ccccc3c2)=C(C#N)[C@@H]1c1ccc(C)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN1CC2(CCC1=O)CCN(C(=O)c1ccc(C)c(C)c1)CC2 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](Cc1cccs1)N(C)C(=O)CSc1nnnn1C1CCCC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1-c1nc(C)c(C(=O)Nc2ccc(cc2)NC(=O)C)s1)CC ### Response: CCc1ccc(-c2nc(C)c(C(=O)Nc3ccc(NC(C)=O)cc3)s2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)NC(=O)C[NH+]1CCC[C@H](C(=O)NCC(F)(F)F)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCN[5*] Fragment 2: [1*]C(=O)c1ccc2c(c1)nc(C)n2C ### Response: CC[C@H](C)[NH+](C)CCNC(=O)c1ccc2c(c1)nc(C)n2C
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)CCNC(=O)CN(C)S(=O)(=O)c1ccccc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1cccc(Br)c1)N1CCC(OC)CC1 ### Response: COC1CCN(C(=O)c2cccc(Br)c2)CC1
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(NC(=O)C2C[C@H](C)O[C@@H](C)C2)cc1NC(C)=O ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCn2c(nc(n2)C)[C@H]1NS(=O)(=O)N1CCC(C(C)(C)C)CC1 ### Response: Cc1nc2n(n1)CCC[C@@H]2NS(=O)(=O)N1CCC(C(C)(C)C)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)(F)F Fragment 2: [5*]N1C[C@@H](C)O[C@H](C)C1 ### Response: C[C@@H]1CN(S(=O)(=O)c2ccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)C[C@@H](C)O1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)NC(=O)[C@@H]1CCC[C@@H](NC(=O)NC[C@@H](C)Nc2ccccc2)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cccc([C@@]2(C(C)(C)C)CCC[NH2+]2)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(/C=C/C(=O)N[C@@H](C)C(=O)N(C)C2CC2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(Cc1nc(-c2ccccn2)no1)C[C@H](O)c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc2ccccc2cc1)[C@@H](O)CNC(=O)NCc1cccc(c1)OC(F)F ### Response: O=C(NCc1cccc(OC(F)F)c1)NC[C@H](O)c1ccc2ccccc2c1
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc(Br)cc1NC(=O)NCc1cccc(C)n1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)[C@H](C)CNC(=O)Nc1cccc(SC(F)F)c1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C)c1NC(=O)CN1CCN(C(=O)Cn2ccccc2=O)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1cccc(-c2nnc(SCC(=O)Nc3ccc(C(C)=O)cc3)n2C)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NC[C@H](O)c1ccco1)c1ccc(OC(F)F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2nnc(SCC(=O)NCCc3ccc(Cl)cc3)n2N)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)c1ccc(C[NH+]2CC=C([C@@H](C)N(C)C(C)=O)CC2)o1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2c(c1)OCCO2 Fragment 2: [10*]N1C(=O)c2ccccc2N[C@H]1[13*] ### Response: O=C1c2ccccc2N[C@@H](c2ccc(O)c(O)c2)N1c1ccc2c(c1)OCCO2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(/C=C/C(=O)c2cccnc2)c1OC ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccccc1OCC(=O)Nc1onc2c1C[C@@H](C)CC2 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2oc(C(=O)NCc3cccc(OCC(=O)N(C)C)c3)cc2c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1C[C@H](C)CN(C(=O)C[NH+](CCC#N)CC(C)(C)C)C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)C[C@@H](NC(=O)N[C@H]1CCCc2c1cnn2C)c1cccs1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(N(C)CCNc1c(n(CC)ccn1)=O)OC(C)(C)C ### Response: CCn1ccnc(NCCN(C)C(=O)OC(C)(C)C)c1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(S(=O)(=O)N2CCc3ccccc3C2)cc1[N+](=O)[O-] ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [16*]c1ccccc1Cl ### Response: COc1ccc(-n2c(-c3ccco3)nc3c(cnn3-c3ccccc3Cl)c2=O)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c([C@@H]([C@H](C2CCC(CC2)C(C)(C)C)O)C)cccc1 ### Response: C[C@@H](c1ccccn1)[C@@H](O)C1CCC(C(C)(C)C)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(Nc1cc(ccc1)C(Nc1cc(ccc1OC)[N+](=O)[O-])=O)C(C)C ### Response: COc1ccc([N+](=O)[O-])cc1NC(=O)c1cccc(NC(=O)C(C)C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N=c1[nH]c2ccccc2[nH]1)c1sccc1C1CC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cnc(CN2C[C@H](C)OCC2(C)C)cn1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a ester group? Cn1cnnc1C[NH+]1CC[C@]2(CCCN(C3CCCC3)C2=O)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(C1CCN(c2n(-c3ccc(cc3)Cl)nc(C)c2NC(C)=O)CC1)NCCc1ccccc1 ### Response: CC(=O)Nc1c(C)nn(-c2ccc(Cl)cc2)c1N1CCC(C(=O)NCCc2ccccc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](CSC)N(C)C(=O)c1ccc(S(=O)(=O)C2CCCC2)cc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CCC[NH+]1[5*] Fragment 2: [1*]C(C)=O ### Response: CC(=O)Nc1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2ccc(F)cc2)cc1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1nn(C)c(C)c1[C@H](C)NCCc1nc2c(F)cccc2n1C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCCC1 Fragment 2: [4*]Cc1ccc(CN[5*])cc1 ### Response: O=C(NCc1ccc(C[NH+]2CCCCC2)cc1)c1ccccc1[N+](=O)[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C[C@H]1CCCN1C(=O)[C@H]1[C@H](C)C1)C ### Response: CC(=O)C[C@H]1CCCN1C(=O)[C@@H]1C[C@H]1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCOc1ccc(NC(=O)N2CCOC[C@H]2C2CC2)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccco1 Fragment 2: [5*]N1CC[NH+]([5*])CC1 ### Response: CC1=NN(c2ccc(C(=O)N3CC[NH+](Cc4ccco4)CC3)cc2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(Cl)cc1CNc1c(C)c(C)nc2ncnn12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [3*]Oc1ccc(N[5*])cn1 ### Response: O=C(CCc1nc2ccccc2[nH]1)Nc1ccc(Oc2ccc(F)cc2)nc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(N)c(SCC(F)F)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CCCN1[5*] Fragment 2: [9*]n1ccccc1=O ### Response: CN(C)C(=O)[C@@H]1CCCN1C(=O)Cn1ccccc1=O
functional_group
### Instruction: Does the molecule contain a amide group? O=C(NCCCn1nc(C(F)(F)F)cc1C1CC1)c1ccc(Br)o1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(O)ccc1C(=O)N1C[C@H](CO)[C@H](C[NH+]2CCN(CCC2)C)C1 ### Response: CN1CCC[NH+](C[C@@H]2CN(C(=O)c3ccc(O)cc3)C[C@@H]2CO)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(C)c([16*])c1 Fragment 2: [8*]C(F)(F)F ### Response: Cc1ccc(C(F)(F)F)cc1N1CC[NH2+]C[C@@H]1C(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@](C)(CC)C(=O)OC Fragment 2: [16*]c1ccccc1C ### Response: CC[C@](C)(NC(=O)COc1ccccc1C)C(=O)OC
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCC(=O)Oc1cccc2ccc(/C=C/c3ccccc3[N+](=O)[O-])nc12 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1cc(NC(=O)CSc2ncnc(c2)N2CCN(c3ccc(cc3)F)CC2)c(cc1)OC ### Response: COc1ccc(C)cc1NC(=O)CSc1cc(N2CCN(c3ccc(F)cc3)CC2)ncn1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([O-])c1coc(-c2csc(-c3ccc(Cl)cn3)n2)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)OCCN1CCN(C(=O)[C@H](C)Oc2cccc(F)c2)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [4*]C[C@@H]1CCC[NH+](C)[C@@H]1[13*] ### Response: CCCCNC(=O)NC[C@@H]1CCC[NH+](C)[C@@H]1c1cccs1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCCO)[C@H]1C[C@H]2CCCC[C@H]2[NH2+]1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(NC[C@@H]1C[NH+]2CCN1CC2)c1ccc(C(F)(F)F)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(OC)cccc1)-c1nc([C@H]2N(C(Nc3ccc(OC)c(c3)F)=O)CCC2)on1 ### Response: COc1ccc(NC(=O)N2CCC[C@H]2c2nc(-c3ccccc3OC)no2)cc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(c2ncccc2oc1=O)CCSCC(=O)N1[C@H](C)CCC[C@H]1C ### Response: C[C@@H]1CCC[C@@H](C)N1C(=O)CSCCn1c(=O)oc2cccnc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCCC[S@@](=O)c1ccc(Cl)c(Cl)c1)C(F)(F)F ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@]1(c2cccc3ccccc23)NC(=O)N(CC(=O)NCCC#N)C1=O ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CNC(=O)C1CCCCC1)NNC(=O)c1ccc(Br)o1 ### Response: 1