task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@H](OC(=O)c1ccccc1OC1CCC1)c1nccs1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(Cl)cc1/N=C(\[S-])Nc1cccc(C)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [4*]Cc1cccnc1N[5*] ### Response: CCCNc1ncccc1C[NH+]1C[C@@H](C)[C@@H](C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(OC2CCCCC2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C[NH+]1C[C@H]2CC[C@@H]1CN(C(=O)C1CCC1)C2)NCCc1ccccc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc(/C=C(\C#N)C(=O)Nc2cccc([N+](=O)[O-])c2)c(Br)cc1O ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1NC(NC1CC1)=O)[C@@H](C)NC(NC1CC1)=O ### Response: C[C@@H](NC(=O)NC1CC1)c1ccc(NC(=O)NC2CC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN1CCN(C(=O)c2n[nH]c(C(C)C)n2)C[C@H]1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cccc(C(=O)N(C)[C@H](C)c2ccccc2F)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(Cl)cc(c1[C@@H]1CC(=O)NC2=NC(=NC([C@@H]12)=O)SC)Cl ### Response: CSC1=NC(=O)[C@@H]2C(=N1)NC(=O)C[C@H]2c1ccc(Cl)cc1Cl
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(O)c(C[NH2+][C@@H]2CCOc3c(OC)cccc32)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)cc(N2CC[C@H](NC(=O)c3sccc3C)C2=O)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])c1ccc(C[C@H]2SC(=O)N(c3ccccc3)C2=O)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? O=C([O-])[C@H]1C=C[C@H](NS(=O)(=O)c2ccc3c(c2)CCO3)C1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1ccc(NC(=O)N(C)[C@H](C)c2ccc(-n3cncn3)cc2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(CNC(c2cc([N-]S(=O)(=O)CC3CCC3)ccc2)=O)ccccc1 ### Response: O=C(NCc1ccccc1)c1cccc([N-]S(=O)(=O)CC2CCC2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)cc1OC Fragment 2: [5*]Nc1nc([14*])cs1 ### Response: COc1ccc(-c2csc(NC(=O)Cc3ccc(SC)cc3)n2)c(OC)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)(OC(NC[C@]1(CCCC[C@@H]1C)NC(C1C[C@@H](O[C@H](C)C1)C)=O)=O)C ### Response: C[C@@H]1CC(C(=O)N[C@]2(CNC(=O)OC(C)(C)C)CCCC[C@@H]2C)C[C@H](C)O1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CC(=O)Nc2ccnc(N(C)C)n2)s1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? CCC[C@H](CC(=O)OC)NC(=O)c1ccc(C#N)[n-]1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1cc2c(=O)n(-c3cccc(Cl)c3)c(=O)n(CC(=O)Nc3ccccc3C(=O)OC)c2s1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)c1ccc(N[5*])cc1 ### Response: CCOC(=O)[C@@H]1CCCN(C(=O)c2ccc(NC(=O)Cc3ccccc3)cc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccco1)C[NH+]1Cc2c3c(ccc2OC1)c(CCC)cc(=O)o3 ### Response: CCCc1cc(=O)oc2c3c(ccc12)OC[NH+](Cc1ccco1)C3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(nc(c1)OCC(F)F)CNC(=O)NC[C@@]1(C)CCCO1 ### Response: C[C@]1(CNC(=O)NCc2cccc(OCC(F)F)n2)CCCO1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)[C@@H](C#N)c1c(F)c(F)c(Br)c(F)c1F ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C(=O)OCc2cc(-c3ccc4c(c3)O[C@H](C)C4)on2)no1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc(N[5*])c1 Fragment 2: [16*]c1ccc(OC)c(F)c1 ### Response: COc1ccc([C@H](C)[NH2+]Cc2cccc(NC(=O)N(C)C)c2)cc1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1c(C(=O)N[C@@H](CO)c2ccccc2F)cccc1[N+](=O)[O-] ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@@H](NC(=O)NCCc2ccc(O)cc2)CN1c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1nc2n(cc(s2)C)c1C[NH+](Cc1ccccc1)CC1(O)CCOCC1 ### Response: Cc1cn2c(C[NH+](Cc3ccccc3)CC3(O)CCOCC3)c(C)nc2s1
functional_group
### Instruction: Does the molecule contain a ketone group? COc1cc(F)cc(C[NH2+]Cc2cccnc2)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H](CC)N(c1[nH+]ccc([C@@H](O)C)c1)CC ### Response: CC[C@H](C)N(CC)c1cc([C@H](C)O)cc[nH+]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(S(=O)(=O)NCCc2cc(N(C)C)nc(-c3ccccn3)n2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C(=O)CSc1nnc(-c2ccccc2F)n1C)[C@H]1CCCc2ccccc21 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? CCc1ccc([C@@H]2C[C@H](C)CCN2c2ncc([N+](=O)[O-])c(N)n2)o1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? C[C@@H](OC(=O)c1ccc(N2CCOCC2)c(F)c1)C1CCOCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1C Fragment 2: [5*]N1C([S-])=C(C#N)C(=O)N[C@H]1[13*] ### Response: COc1cccc([C@@H]2NC(=O)C(C#N)=C([S-])N2c2ccccc2C)c1
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1ccccc1NC(=O)c1cccc(S(=O)(=O)N(C)c2cccc(Cl)c2)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C([7*])C#N Fragment 2: [5*]Nc1cccc([N+](=O)[O-])c1 ### Response: COc1cccc(/C=C(\C#N)C(=O)Nc2cccc([N+](=O)[O-])c2)c1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1ccc(cc1)C(N1CC[C@](F)(C1)C(OC)=O)=O)N(CC)CC ### Response: CCN(CC)C(=O)c1ccc(C(=O)N2CC[C@@](F)(C(=O)OC)C2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1nn(C)c(C[C@]2(C[NH3+])CCCC(C)(C)[C@@H]2O)c1Cl ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cncn1 Fragment 2: [5*]N1CCC[C@H]([15*])C1 ### Response: O=C([C@H]1CCOc2ccccc21)N1CCC[C@H](n2cncn2)C1
functional_group
### Instruction: Does the molecule contain a halide group? CNC(=O)[C@@H]1CCCN(C(=O)Nc2nn(-c3ccccc3Cl)cc2C)C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1nc([C@@H]2CCCO2)sc1NC(=O)C(C)(C)C ### Response: CC(C)(C)C(=O)Nc1nnc([C@@H]2CCCO2)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(OC)cc1 Fragment 2: [1*]C(=O)[C@@H]1CC(=O)N(N2CCN(C)CC2)/C(=N/c2ccccc2)S1 ### Response: COc1ccc(NC(=O)[C@@H]2CC(=O)N(N3CCN(C)CC3)/C(=N/c3ccccc3)S2)cc1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1nc2n(n1)C[C@@H](Nc1nc3c(cnn3C(C)(C)C)c(=O)[nH]1)CC2 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2c(C)nc(Nc3nc(C)cc(C)n3)nc2c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cn1cc(CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cn1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)C1(N(C)Cc2c[nH]nc2-c2ccc(C)cc2)CCCC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(Cl)cc1)[C@H](C[NH2+]CC)Cc1scc(n1)C ### Response: CC[NH2+]C[C@H](Cc1nc(C)cs1)c1ccc(Cl)cc1
functional_group
### Instruction: Does the molecule contain a amide group? CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)C(C)(C)C(=O)N2 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [5*]Nc1ccc(Cl)cc1F ### Response: COc1ccc2[nH]cc(CC(=O)Nc3ccc(Cl)cc3F)c2c1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1ccc(Nc2nc(NCCN3CCOCC3)nc3c2cnn3C)cc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C/C(=N\Nc1nc(C)cc(C)n1)c1ccc(C#N)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=C(C)CN(CC)C(=O)[C@H](C)N1CCN(C(=O)C2CCCC2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? C[C@H](CO)[C@@H](C)NC(=O)Nc1cc(-c2ccccc2)on1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CN(C(=O)Nc1ccc2c(c1)oc(=O)n2C)C1CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(=O)NC[C@H](CCO)c1ccccc1)[C@@H]1CCCC1(C)C ### Response: CC1(C)CCC[C@H]1NC(=O)NC[C@H](CCO)c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])CCc1cc2n(n1)CCCN(c1ccc(C(=O)N3CCCC3)cn1)C2 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C[NH+]1CCC(C(=O)[O-])CC1)Nc1ccccc1Oc1ccccc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(NC(=O)COc2cccc3ccc(N4CCCC4)nc23)c1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H](C)NC(=O)CSc1ccc2c(c1)OCCO2 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(Oc2ccccc2F)c(F)cc1[N+](=O)[O-] ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(C[NH2+][C@@H](C)c2cscc2)sc1)C([O-])=O ### Response: C[C@H]([NH2+]Cc1cc(C(=O)[O-])cs1)c1ccsc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(NCc1occc1)[C@H]1[C@@H](c2ccc(cc2)C)Nn2c(C)nnc2S1 ### Response: Cc1ccc([C@H]2Nn3c(C)nnc3S[C@H]2C(=O)NCc2ccco2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN1C(SCC2[NH+]=c3ccccc3=[NH+]2)=NN[C@H]1c1cccc(NC(=O)c2ccccc2F)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? CCOC(=O)[C@@H]1CCCN(C(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C[C@@H]1CN([C@H](C(N)=O)c2ccc(F)cc2)CCN1Cc1[nH+]ccn1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C/C=C/CS Fragment 2: [5*][NH+]1CC[C@@H](C)C1 ### Response: C[C@@H]1CC[NH+](C/C=C/CS)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1cc(c(cc1)OC)Cn1c(nc2c1cccc2)CS(C)(=O)=O ### Response: COc1ccc(Cl)cc1Cn1c(CS(C)(=O)=O)nc2ccccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(C)cc1)-c1nc(cs1)CC(OC[C@@H]1CC(N(C1)C1CC1)=O)=O ### Response: Cc1ccc(-c2nc(CC(=O)OC[C@@H]3CC(=O)N(C4CC4)C3)cs2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1n[nH]c(C)c1NC(=O)NC1(c2ccc(F)cc2F)CCOCC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1n(C)ncc1-c1nc(C(N[C@H](c2cc3c(cc2)OCC(=O)N3)C)=O)cs1 ### Response: C[C@H](NC(=O)c1csc(-c2cnn(C)c2)n1)c1ccc2c(c1)NC(=O)CO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)CCC(=O)c1ccc(OC)c(OC)c1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC1C(C1CC1)C(=O)Oc1cc2nccnc2cc1 ### Response: O=C(Oc1ccc2nccnc2c1)C(C1CC1)C1CC1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=[N+]([O-])c1ccc(S(=O)(=O)N2CCN(CCO)CC2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@](Nc1ccc(C(N)=O)nn1)(C(=O)[O-])c1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(oc(cc1)C[NH2+][C@H](COC)c1ccc(F)c(c1)F)CO ### Response: COC[C@@H]([NH2+]Cc1ccc(CO)o1)c1ccc(F)c(F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N(C1CC1)c1nc(cs1)C)c1ccc(cc1)CNC(C)=O ### Response: CC(=O)NCc1ccc(C(=O)N(c2nc(C)cs2)C2CC2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COCCN(Cc1ccccc1)C(=O)c1ccc(-c2ccc3c(c2)OCCO3)s1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(=O)OC Fragment 2: [9*]n1c2ccc(OC)cc2c2nc(C)sc21 ### Response: COC(=O)Cn1c2ccc(OC)cc2c2nc(C)sc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)[C@H]1CCC[C@](CO)([NH2+]C)C1 Fragment 2: [15*][C@@H]1CCCN(C)C1 ### Response: C[NH2+][C@@]1(CO)CCC[C@H](N(C)[C@@H]2CCCN(C)C2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(OC(=O)NC[C@@H]1CCC[NH+](CN2CCCCC2=O)C1)(C)C ### Response: CC(C)(C)OC(=O)NC[C@@H]1CCC[NH+](CN2CCCCC2=O)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc2cnn(CC(=O)Nc3cccnc3)c(=O)c2c1OC ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](CO)CSCC(=O)N[C@@H](C)c1ccc(F)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc2c(cc1[16*])n(CC)c(=O)n2CC Fragment 2: [1*]C(=O)N[5*] ### Response: CCn1c(=O)n(CC)c2cc(N3CCCCC3)c(NC(=O)Nc3cc(C)ccc3C)cc21
functional_group
### Instruction: Does the molecule contain a amine group? CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3C)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C[C@H]([NH2+]CC(C)(C)C[C@@H](C)O)c1cnccn1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(=O)c2c([nH]1)NC1=C(C(=O)CC(C)(C)C1)[C@H]2c1cc(OC)ccc1OC Fragment 2: [16*]c1ccccc1 ### Response: COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccs1 Fragment 2: [1*]C(=O)CN([5*])C ### Response: CO[C@H]1CCC[C@@H](OC(=O)CN(C)C(=O)c2cccs2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O[C@@H]1CCCC[C@H]1c1ccc(Cl)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(F)ccc(SCCC(=O)Nc2c(N(C)C)cccc2)c1 ### Response: CN(C)c1ccccc1NC(=O)CCSc1ccc(F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(CCN(C(c2nn(c(=O)cc2)C)=O)C1)Oc1c(C)cccc1C ### Response: Cc1cccc(C)c1OC1CCN(C(=O)c2ccc(=O)n(C)n2)CC1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC(=O)c1cccc(NC(=O)C(=O)NCc2ccc(Cl)cc2)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(CCNC(=O)[C@@H]2CCC[NH+](C)C2)on1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCc1ccccc1 Fragment 2: [5*]N(C)S(=O)(=O)c1cncc(F)c1 ### Response: CN(CCc1ccccc1)S(=O)(=O)c1cncc(F)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cccc(C(C)(C)C[NH2+]C2CC[NH+](CC=C(C)C)CC2)c1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](N[C@@H]1CCc2ccccc21)C(=O)Nc1ccc(Cl)cn1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C(=O)N[C@@H](C)CCC2CCCC2)cc1[N-]S(C)(=O)=O ### Response: 4