task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c(cc1)N)N(C(NC1CCCC1)=O)CCO ### Response: Nc1ccccc1N(CCO)C(=O)NC1CCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(=O)c(C#N)cn(CC)c1=O Fragment 2: [5*]N1CCN([5*])CC1 ### Response: CCn1cc(C#N)c(=O)n(CC(=O)N2CCN(S(=O)(=O)c3ccc4c(c3)CCCC4)CC2)c1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(NC(=O)c2cccc(n2)C)[C@H](CCCC1)C(F)(F)F ### Response: Cc1cccc(C(=O)N[C@@H]2CCCC[C@@H]2C(F)(F)F)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Clc1ccc(-c2nnc(SCc3nc4ccccc4o3)o2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCN(C(=O)CCNS(=O)(=O)c2c(c(c(C)cc2)N(C)S(=O)(=O)C)C)C1 ### Response: Cc1ccc(S(=O)(=O)NCCC(=O)N2CCCC2)c(C)c1N(C)S(C)(=O)=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc2nc(CSc3ccccc3NS(=O)(=O)c3cc(C)c(C)cc3C)cc(=O)n2o1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COC(=O)[C@@]1(NC2CCCC2)CCCS[C@H]1C ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNc1cc(C)ccc1C(=O)N[C@@H]1CC[NH+]2CCC[C@H]12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc([16*])c1 Fragment 2: [4*][C@@H]([8*])CN[5*] ### Response: COC(=O)c1cccc(C(=O)NC[C@H](c2ccc(C)o2)[NH+]2CCCC2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C(=S)N[C@H]2C[C@]1(C)Oc1ccc(C)cc12 Fragment 2: [16*]c1cccc(C)c1 ### Response: Cc1cccc(N2C(=S)N[C@H]3C[C@]2(C)Oc2ccc(C)cc23)c1
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(N[C@H]1C=C[C@@H](C(=O)[O-])C1)c1ccc(Br)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](CNc1nc(C2CC2)no1)CC1(C)OCCO1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(Br)c1 Fragment 2: [7*]C(N)[C@@]1(C#N)[C@H]([15*])C1(C#N)C#N ### Response: N#CC(C#N)=C(N)[C@@]1(C#N)[C@H](c2cccc(Br)c2)C1(C#N)C#N
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@H](OC1)CCC[C@H]([NH2+]C)c1[nH]ccn1 ### Response: C[NH2+][C@@H](CCC[C@@H]1CCCO1)c1ncc[nH]1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(Cl)nc1Cl Fragment 2: [5*]N[C@H]1CCCc2ccc(F)cc21 ### Response: O=C(N[C@H]1CCCc2ccc(F)cc21)c1ccc(Cl)nc1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CN(C(=O)[C@@H]2CCS(=O)(=O)C2)C[C@H](C)O1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2cnn(CCC(=O)N[C@H](C)c3ccccc3)c2c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CN(C[C@@H]1CCC[NH+]1C)CC1(C[NH2+]C2CC2)CCOCC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)COc1ccc([C@H]2CC(O)=Nc3c2ncn3-c2ccccc2F)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? C#CCNCC(=O)NC[C@@H](C)CO ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)[C@H]1CCCc2ccccc21 Fragment 2: [1*]C(=O)CO[3*] ### Response: CCc1nn(C)cc1C(=O)OCC(=O)N(C)[C@H]1CCCc2ccccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(NS(=O)(=O)c2ccc(C#N)cc2C)n(n1)Cc1cc(ccc1)C ### Response: Cc1cccc(Cn2nccc2NS(=O)(=O)c2ccc(C#N)cc2C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cc[nH]n1 Fragment 2: [3*]OCC ### Response: CCOc1ccc(C(=O)NNC(=O)c2cc[nH]n2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Nc1ccc(N2CCOCC2)nc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](O)c1cccc(NC(=O)c2ccccc2C(=O)c2ccccc2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2nc(N3CCC[C@H](C(=O)NCCc4c[nH]c5ccccc45)C3)sc2c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CCCn1c(C)nn(C[NH+]2CCC(C(=O)NC(C)C)CC2)c1=S ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cnc(C(=O)NCCCc2ccccc2)cn1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC(C)C Fragment 2: [1*]C(=O)C(C)C ### Response: CC(C)CCNC(=O)c1ccc(Cl)c(NC(=O)C(C)C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](Nc1cc(N2CC[NH+](C)CC2)nc(N)n1)c1ccccc1-n1cccn1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. NC(=O)CONC(=O)CCCc1ccc2[nH]c(=O)[nH]c2c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(Cl)ccc1Cl Fragment 2: [4*]C[C@H]1CN(C)CCO1 ### Response: CN1CCO[C@@H](CNc2cc(Cl)ccc2Cl)C1
functional_group
### Instruction: Does the molecule contain a amide group? CN(c1ccccc1)S(=O)(=O)c1cccc(NC(=O)Cc2csc(N3CCCC3=O)n2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NS(=O)(=O)CCNC(=O)c1c[nH]nc1-c1ccc(F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C[C@H](O)COc1ccccc1C(F)(F)F)C(=O)c1cnccn1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amine group? O=C1/C(=C/c2ccc(Cl)cc2Cl)SC(=S)N1C[C@H]1CCCO1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@H](CN(c2n(c3c([nH+]2)cccc3)C)CC1)C(NC1CCCC1)=O ### Response: Cn1c(N2CCC[C@@H](C(=O)NC3CCCC3)C2)[nH+]c2ccccc21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Oc1ccc(Cl)cc1C1=[NH+]CCN1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])CC1c2ccccc2CCc2ccccc21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](NC(=O)NCCNC(C)=O)c1cccs1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(N2[C@@H](C3CCOCC3)CNC2=[NH2+])ccc(c1Br)Cl ### Response: [NH2+]=C1NC[C@H](C2CCOCC2)N1c1ccc(Cl)c(Br)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NC[C@H](O)C[NH+]1CCc2ccccc2C1)N[C@@H]1CC[NH+]2CCCC[C@H]12 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@@H](C)O[C@H](C)C1 Fragment 2: [1*]C(=O)CN[5*] ### Response: C[C@@H]1CN(C(=O)CNC(=O)c2cc3ccccn3n2)C[C@@H](C)O1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc2c1sc(C(N(C)C)=O)c2[C@H]1CN(CC1)S(=O)(=O)N1CCCC1 ### Response: CN(C)C(=O)c1sc2ccccc2c1[C@@H]1CCN(S(=O)(=O)N2CCCC2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(OC)c(Cl)c1 Fragment 2: [8*][C@H](C)CC ### Response: CC[C@@H](C)n1c(=O)c2ccccc2n(CC(=O)Nc2ccc(OC)c(Cl)c2)c1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C1=NO[C@@H]([C@@H]2CCC[NH+]2Cc2ncc[nH]2)N1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+]([C@@H](CC1)c1cccc2c1OCCO2)Cc1noc(C(C)C)n1 ### Response: CC(C)c1nc(C[NH+]2CCC[C@H]2c2cccc3c2OCCO3)no1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3ccc(NC(C)=O)cc3)C2)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+](CC[C@H]([C@H]1C)N(C(C[NH+](CC)CC)=O)C)C ### Response: CC[NH+](CC)CC(=O)N(C)[C@@H]1CC[NH+](C)C[C@@H]1C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CO[C@]2(CCSC2)C[C@@H]1Nc1ccc(cc1)NC(C)=O ### Response: CC(=O)Nc1ccc(N[C@@H]2CCO[C@]3(CCSC3)C2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1cc(cc(C)c1NC(CSc1[n-]c2c(ncc(Br)c2)n1)=O)C ### Response: Cc1cc(C)c(NC(=O)CSc2nc3ncc(Br)cc3[n-]2)c(C)c1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1nc(CSc2ccccc2Cl)no1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Cn1cnnn1)(=O)Nc1ccc(NC(=O)CC(C)C)cc1 ### Response: CC(C)CC(=O)Nc1ccc(NC(=O)Cn2cnnn2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(=O)CN2C(=O)[C@]3(NC2=O)c2ccccc2CC3)ccc1S(=O)(=O)N1CCCC1 ### Response: O=C(CN1C(=O)N[C@@]2(CCc3ccccc32)C1=O)c1ccc(S(=O)(=O)N2CCCC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(Cc1ccccc1)C(=O)c1cc(NC(=O)Cc2ccccc2)n(C)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [4*][C@H](OC)C(=O)OC ### Response: COC(=O)[C@H](NC(=O)OCc1ccccc1)OC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C)cc1NC(=O)[C@H]1CCCN1c1cc(C)ccc1[N+](=O)[O-] ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(NC(=O)c2cc(F)cc([N+](=O)[O-])c2N)cc1Cl ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)c1ccc(N2C(=O)/C(=C3/C(=O)N(C)c4ccccc43)SC2=S)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(S(=O)(=O)N2CCN(c3nc4c(C)cccc4cc3C=O)CC2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@]1(c2cc(F)ccc2F)NC(=O)N(C[C@H]2CCCCO2)C1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? Fc1cc(F)cc(COC2C[NH2+]C2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](O)c1ccc(O[C@@H]2CCOC3(CCCC3)C2)cc1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1cnn(Cc2ccccc2)c1)c1ccccc1Br ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1cccc(-c2noc(CSCc3noc(C)n3)n2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc([C@@H]2[NH2+][C@H](C(=O)[O-])CS2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CSc1ccc(C(=O)Oc2ccccc2F)cn1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCn1ncc(C(=O)N[C@H](c2ccc(C)cc2)c2cccnc2)c1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc2cnccc12 Fragment 2: [15*][C@H]1CCCC1(C)C ### Response: CC1(C)CCC[C@@H]1Nc1cccc2cnccc12
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C#CCNC(=O)c1ccc(N2CC[NH+](CCc3ccccc3)CC2)nc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([O-])CC/C(=N\NC(=O)c1ccccc1Br)c1ccccc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1OCC[C@@H]1C(=O)N[C@@H]1CCN(c2cccc[nH+]2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(c1ccc(cc1)C)(=O)N1CCC[C@H]1C(Nc1cccc(c1)-c1[nH]c2ccccc2n1)=O ### Response: Cc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)Nc2cccc(-c3nc4ccccc4[nH]3)c2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(N=N[C@@H]2N=C(CS[C@H](C2=1)c1cc2n(c(n(c2cc1)C)=O)C)O)C ### Response: CC1=C2[C@H](N=N1)N=C(O)CS[C@H]2c1ccc2c(c1)n(C)c(=O)n2C
functional_group
### Instruction: Does the molecule contain a amide group? CN(c1cccnn1)C1CCN(C(=O)c2[nH]nc3ccccc23)CC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](C)CCSc1ccc(NC(=O)N2CCC3(CCC3)C2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(=O)[nH]c(-c2ccc(NC[C@H](CCO)c3ccccc3)nc2)n1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[S@](=O)Cc1cccc(C(=O)Nc2cnn(Cc3ccccc3)c2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CN1CCN(C(=O)c2cc(-c3ccccc3)nc3ccccc23)CC1)N1CCCC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(NC(=O)CCc2nc(C)no2)cc1Cc1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NC[C@@H]1CCC[NH+](C1)Cc1oc2c(c1)cc(F)cc2)C(C)C ### Response: CC(C)C(=O)NC[C@@H]1CCC[NH+](Cc2cc3cc(F)ccc3o2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(CC1CC1)[C@H](C)/C([O-])=N/S(=O)(=O)c1c2c(ccc1)cc(cn2)C ### Response: Cc1cnc2c(S(=O)(=O)/N=C(\[O-])[C@@H](C)OCC3CC3)cccc2c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cccc2c1OC[C@@H](NC(=O)N1CCC3(CC1)OCCO3)C2 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C(=O)N2CCc3nc(NC(=O)c4cc(C)on4)sc3C2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[C@H](C)C(C)C Fragment 2: [1*]C(=O)CCN[5*] ### Response: Cc1cccc(NC(=O)CCNC(=O)C[C@H](C)C(C)C)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)ccc2n(c(nc21)[C@@]([NH3+])(C)CC)C1CC1 ### Response: CC[C@@](C)([NH3+])c1nc2cc(C)ccc2n1C1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)NN(C)C Fragment 2: [16*]c1ccccc1 ### Response: CN(C)NC(=O)c1ccsc1NC(=O)Cc1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H]1[C@H](C[C@@H]([C@H](O)C2([NH+]3CCCC3)CCCC2)CC1)C ### Response: C[C@H]1CC[C@H]([C@H](O)C2([NH+]3CCCC3)CCCC2)C[C@@H]1C
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH+]([C@@H]1CCCC[C@@H]1O)(CC1(O)CCC(C)CC1)C(C)C ### Response: CC1CCC(O)(C[NH+](C(C)C)[C@@H]2CCCC[C@@H]2O)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(F)(c1c(cccc1)CNC(=O)COc1ccccc1F)(F)F ### Response: O=C(COc1ccccc1F)NCc1ccccc1C(F)(F)F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C#N)NC(=O)c1ccnc(OC2CCCCC2)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CS(=O)(=O)c1cccc(C(=O)N2CCC[C@@H](n3cccn3)C2)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]([NH3+])c1nc2ccc(Cl)cc2n1Cc1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O/N=C(/[C@H](C(=O)N(CC)C[C@H](CC)C)c1ccccc1)N ### Response: CC[C@H](C)CN(CC)C(=O)[C@@H](/C(N)=N/O)c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1NCCc2nn(Cc3cc(F)ccc3F)cc21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C(=O)N[C@@H]2C(=O)Nc3c(c(C)nn3C)[C@H]2c2cccc(C)c2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N1CCC(CC)(CC)C1 Fragment 2: [5*]N1CCC(CC)(CC)C1 ### Response: CCC1(CC)CCN(C(=O)NC(=O)CCC(=O)[O-])C1
functional_group
### Instruction: Does the molecule contain a amide group? CCCCOC[C@@H]([NH3+])c1cc(C)ccc1C ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(Cl)ccc1NS(=O)(=O)c1cccc(Cl)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H](C)[n+]1ccccc1 Fragment 2: [5*]Nc1cccc([N+](=O)[O-])c1 ### Response: C[C@H](C(=O)Nc1cccc([N+](=O)[O-])c1)[n+]1ccccc1