task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)(C)NC(=O)CNC(=O)Nc1cnn(CC(F)F)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccnc(C[C@@H](C)O)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)[C@@H](C)C[NH+](C)C1CCC(C)(c2ccccc2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? COc1ccc(C[C@@H](Cl)C2C(C)(C)C2(C)C)cc1OC ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. Cn1c2c(cc(cc2)C(N2CCCC[C@H](C2)SCC)=O)nc1 ### Response: CCS[C@@H]1CCCCN(C(=O)c2ccc3c(c2)ncn3C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [5*]Nc1ccc(C)c(C)c1 ### Response: Cc1ccc(NCc2nnc(C(C)(C)C)o2)cc1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](CNc1ccc([N+](=O)[O-])cc1)NS(=O)(=O)c1ccc2ccccc2c1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#Cc1ccc(-c2noc(CCC(=O)c3ccc(F)cc3)n2)nc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc(F)c(NC(=O)c2cccnc2SC)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@H](O)COCc1occc1)[NH+]1C(C)(C(C)(C1)C)C ### Response: CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1S(=O)(C[C@@H]2[C@H]1S/C(N2c1ccc(cc1)C(C)C)=N\C(CCc1ccccc1)=O)=O ### Response: CC(C)c1ccc(N2/C(=N/C(=O)CCc3ccccc3)S[C@H]3CS(=O)(=O)C[C@H]32)cc1
functional_group
### Instruction: Does the molecule contain a phenol group? CCC[C@@]1(C=O)NC(=O)NC1=O ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [1*]C(=O)[C@H]([4*])C ### Response: C[C@H](C(=O)N1CCOCC1)[NH+]1CCN(Cc2ccc3c(c2)OCO3)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[NH+](CCn2cc(NC(=O)Nc3cc(OC)cc(F)c3)cn2)CC1 ### Response: COc1cc(F)cc(NC(=O)Nc2cnn(CC[NH+]3CCCCC3)c2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(OCC(=O)NNC(=O)NC2CC[NH+](C)CC2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)C(=O)c1cccc(NC(=O)C[NH2+]C2CCCCC2)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](NC(=O)/C(C#N)=C/c1ccc(-n2cccn2)cc1)c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NC(C(=O)N2C[C@H](O)[C@@H](CC2)C)=O)c2c(nccc2)ccc1 ### Response: C[C@@H]1CCN(C(=O)C(=O)Nc2cccc3ncccc23)C[C@@H]1O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1c(Cl)cc(C[NH+]2CCC(N3CCCCC3=O)CC2)cc1OC ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc(C[NH+](C)[C@H](C)c2ccc(C(=O)[O-])o2)cs1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@H](c1ccccc1)[C@@](C)(O)C(=O)[O-] ### Response: 6
functional_group
### Instruction: Does the molecule contain a ketone group? O=c1c2ncccc2n(Cc2ccc(Cl)cc2Cl)c(=O)n1Cc1ccccn1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCC1CC1)C1([NH2+]Cc2cnn(-c3ccccc3)c2)CCCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H]1C[C@H]([NH2+][C@@H]2C[C@@H]2C2CCCCC2)CN1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[4*] Fragment 2: [5*]NS(=O)(=O)c1cccc2nsnc12 ### Response: Cc1cccc(N2CCN(C(=O)CCNS(=O)(=O)c3cccc4nsnc34)C[C@H]2C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2nc(N=C3NCN([C@@H]4CCCC[C@H]4C)CN3)nc(C)c2c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1ccc(=O)[nH]c1=O)NC[C@H]1CCOC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccn([9*])n1 Fragment 2: [15*]C1CCCC1 ### Response: C[C@H](CNC(=O)c1ccn(C2CCCC2)n1)c1nc(-c2ccccc2)no1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NC(=O)CN(Cc1ccccc1N)C(=O)N[C@H]1CCOC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. COC(=O)c1c(cccc1)NC(=O)c1ccc(cc1OC)OC ### Response: COC(=O)c1ccccc1NC(=O)c1ccc(OC)cc1OC
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)c1c(C)nn2c1ncc1c(=O)n(N3CC[NH+](C)CC3)ccc12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC1(CC)CC1 Fragment 2: [5*]Nc1cnn(C[8*])c1 ### Response: CCC1(CNC(=O)Nc2cnn(C[C@@H]3CCCO3)c2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [15*]C1CCCC1 ### Response: CC[NH+](CC(=O)Nc1c(C)cccc1C)C1CCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC[C@@H](C)NC(=O)Cc1ccc(F)cc1F ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CN(C(=O)CN2CCO[C@H](CC(=O)[O-])C2)CCO1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@]1(c2ccc(Cl)cc2)NC(=O)N(CC(=O)Nc2c(C(C)C)cccc2C(C)C)C1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-]/C(COc1cc2c(cc1)CCC2)=N\S(=O)(=O)c1cccnc1 ### Response: O=S(=O)(/N=C(\[O-])COc1ccc2c(c1)CCC2)c1cccnc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc([C@H](C)NC(=O)N2CCc3cc(F)ccc3C2)s1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cnc([14*])o1 Fragment 2: [5*]Nc1ccc([16*])cc1 ### Response: CC(C)c1cnc(-c2ccc(NC(=O)c3cccc4cc[nH]c34)cc2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(C)cc(C)c1 Fragment 2: [8*]CS(=O)(=O)[C@H]1CC[C@H]([NH2+]C)[C@@H]1C ### Response: C[NH2+][C@H]1CC[C@H](S(=O)(=O)Cc2cc(C)cc(C)c2)[C@H]1C
functional_group
### Instruction: Does the molecule contain a halide group? CC(C)[C@H]([NH2+]Cc1ccc(OC(F)(F)F)cc1)c1ccccn1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@H](O)c1ccc2c(c1)oc(=O)n2CC Fragment 2: [15*]C1(C)CCCC1 ### Response: CCn1c(=O)oc2cc([C@@H](O)C3(C)CCCC3)ccc21
functional_group
### Instruction: Does the molecule contain a amine group? CNc1nc2c(s1)C(C)(C)OC2(C)C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/C(Nc1ccc(C(=O)[O-])c(O)c1)=C1/C(=O)O[C@H](C)C1=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1CC1 Fragment 2: [16*]c1ccccc1 ### Response: Nc1cc(C(=O)O[C@H](C(=O)NC2CC2)c2ccccc2)ccc1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH+](C)CCN(Cc1cccs1)C(=O)c1cc(-c2ccccc2)[nH]n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(C)[C@@H](CNC(=O)CCS(C)(=O)=O)c1ccccc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(CN2CCC([NH+]3CCC[C@@H](C3)C(=O)N3CCC(CC3)F)CC2)ccn1 ### Response: O=C([C@H]1CCC[NH+](C2CCN(Cc3ccncc3)CC2)C1)N1CCC(F)CC1
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1cc(N(C)C)ccc1NC(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? FC(F)(F)c1ccccc1OC[C@H]1CO1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc2c(c1)OC[C@H](CNC(=O)CCN1CCCCCC1=O)C2 ### Response: 0
functional_group
### Instruction: Does the molecule contain a nitro group? CCOC(=O)N1CCC(NC(=O)N(C)Cc2ccc(C(C)C)cc2)CC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=C(C)COc1ccccc1NCC(=O)NC1CCCCC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(Nc1c(cc(N[C@H](c2ccc3cc(OC)ccc3c2)C)cc1)OC)=O ### Response: COc1ccc2cc([C@H](C)Nc3ccc(NC(C)=O)c(OC)c3)ccc2c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1C[C@@H](C)CN(S(=O)(=O)c2ccc(C(=O)Nc3nnc([C@@H]4CCCO4)o3)cc2)C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc(OCc2ccc(OC)c(OC)c2Br)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [4*][C@H](C)C12CC3CC(CC(C3)C1)C2 ### Response: CCOc1cc(C[NH2+][C@H](C)C23CC4CC(CC(C4)C2)C3)ccc1OC
functional_group
### Instruction: Does the molecule contain a ether group? O=C(NCc1ccc(-n2ccnc2)nc1)C(=O)Nc1ccc(-c2ccccc2)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(=O)[C@H]1N(C(=O)C2CC2)CCC1)c1c(OCC2CC2)cccc1 ### Response: O=C(NCc1ccccc1OCC1CC1)[C@@H]1CCCN1C(=O)C1CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(=O)[C@@H](C)c1ccc(CC)cc1)Nc1nnc(-c2ccccc2)cc1 ### Response: CCc1ccc([C@H](C)C(=O)NNc2ccc(-c3ccccc3)nn2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([16*])cc1 Fragment 2: [5*]Nc1ccc(C)cc1O ### Response: Cc1ccc(NC(=O)c2ccc(CS(C)(=O)=O)cc2)c(O)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O[C@H](CN[C@H]1CCOc2ccc(F)cc21)c1ccccc1Cl ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(nc([C@H](c2ccccc2)OC)o1)-c1c(C)ncc2C[NH2+]CCc12 ### Response: CO[C@@H](c1ccccc1)c1nc(-c2c(C)ncc3c2CC[NH2+]C3)no1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1ccc(-c2csc(NC(=O)c3ccc(S(C)(=O)=O)cc3)n2)cc1OC ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(C)C)nc(C)c(s1)[C@@H](C)NCCc1nncn1C1CC1 ### Response: Cc1nc(C(C)C)sc1[C@@H](C)NCCc1nncn1C1CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O[C@@H](CSc1cccc(C(F)(F)F)c1)CN1CCN(c2ccc(F)cc2)CC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(OCc1nncn1C1CC1)[C@H]1C[C@@H]1c1cccc2ccccc12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [4*]Cc1cc(OC)c(O)c(OC)c1 ### Response: COc1cc(CN2CCN(C(=O)c3cccnc3)CC2)cc(OC)c1O
canonicalization
### Instruction: Canonicalize the following SMILES string. C(/N1C[C@H](C)CCC1)(NC[C@H]1CN(CC1)CC(F)(F)F)=[NH+]/C ### Response: C/[NH+]=C(/NC[C@@H]1CCN(CC(F)(F)F)C1)N1CCC[C@@H](C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(Cl)c1 Fragment 2: [10*]N1C(=O)N[C@]([13*])(C)C1=O ### Response: C[C@@]1(c2cccc(Cl)c2)NC(=O)N(Cc2cc(F)cc3cccnc23)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#Cc1nc(/C=C/c2ccc(F)cc2)oc1N1CCN(C(=O)c2cccc(F)c2)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. s1cnnc1NC(N[C@H]1CC[NH+]([C@H]1c1ccc(Cl)cc1)C)=O ### Response: C[NH+]1CC[C@H](NC(=O)Nc2nncs2)[C@@H]1c1ccc(Cl)cc1
functional_group
### Instruction: Does the molecule contain a ester group? O=C(NCc1ccncc1)c1cc2cc([N+](=O)[O-])ccc2s1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]1CCCC[C@@H]1N[5*] Fragment 2: [5*]NC[C@@H]1CCCC[C@@H]1N[5*] ### Response: Cc1ccc(CC(=O)N[C@H]2CCCC[C@H]2CNC(=O)OC(C)(C)C)cc1O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1nnc(C(F)(F)F)s1)C1CCN(C(=O)C2CC2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(Cl)c(Cl)c1 Fragment 2: [1*]C(=O)c1ccc([N+](=O)[O-])cc1Cl ### Response: N#C[C@@H](NC(=O)c1ccc([N+](=O)[O-])cc1Cl)c1ccc(Cl)c(Cl)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[C@H]2CC[C@@H](C1)[NH+]2C Fragment 2: [5*]Nc1cc([16*])ccc1C ### Response: Cc1ccc(C(N)=O)cc1NC(=O)N1CC[C@H]2CC[C@@H](C1)[NH+]2C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(F)c([16*])c(F)c1 Fragment 2: [8*]CC[NH3+] ### Response: C[C@H]1CC(Oc2c(F)cc(CC[NH3+])cc2F)C[C@H](C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Oc2nc(Cl)ncc2F)cncc1Cl ### Response: Fc1cnc(Cl)nc1Oc1cncc(Cl)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(c(cc1)C)-n1nnnc1)NC(=O)C(NC[C@@H](c1ccco1)[NH+](C)C)=O ### Response: Cc1ccc(NC(=O)C(=O)NC[C@@H](c2ccco2)[NH+](C)C)cc1-n1cnnn1
functional_group
### Instruction: Does the molecule contain a nitrile group? O=C(c1cccc(OCC(F)F)n1)N1CC[C@@]2(CCOC2)C1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2c(c1)C(=O)N([C@@H](C)C(=O)N[C@H]1CCCOC1)CC1(CC[NH+](C)CC1)O2 ### Response: 0
functional_group
### Instruction: Does the molecule contain a nitrile group? CCOC(=O)c1sc(NC)nc1C(F)(F)F ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2c(c(ncn2)NC[C@H](c2ccccc2)N2CCOCC2)cc1 ### Response: c1ccc([C@@H](CNc2ncnc3ccccc23)N2CCOCC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2ccccc21 Fragment 2: [1*]C(=O)[C@@H]([4*])C ### Response: COc1cccc(Nc2nnc(S[C@@H](C)C(=O)N3CCc4ccccc43)s2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(CNC(=O)N2CCc3c([nH]c4ccccc34)[C@H]2C)cc1OC ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? CC(C)OC(=O)c1cc(-c2ccc(/C=C3/C(=O)N(C)C(=O)N=C3[O-])o2)ccc1Cl ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [10*]N1C(=O)[C@@H]2[C@H](C1=O)[C@@H]1c3ccccc3C=CN1[C@@H]2C#N ### Response: N#C[C@@H]1[C@@H]2C(=O)N(c3ccc(F)cc3)C(=O)[C@@H]2[C@@H]2c3ccccc3C=CN12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1cc2c3c([nH]c2cc1S(=O)(=O)N(C)Cc1ccco1)CCCC3=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cnn([9*])c1[14*] Fragment 2: [16*]c1ccc(C)cc1 ### Response: Cc1ccc(N2CCC[C@H](NC(=O)c3cnn(CC(C)C)c3C3CC3)C2=O)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1cccc(NC(=O)[C@@H](C)N2CCN(c3cc(Cl)ncn3)CC2)c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a ketone group? COc1ccc(-c2n[nH]cc2C[NH+]2CCC[C@H]2c2nc3ccc(F)cc3[nH]2)c(OC)c1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([C@H]1C=C(C2CC2)N=N1)N(Cc1ccccn1)C[C@@H]1CCCO1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccc(C)cc1 Fragment 2: [14*]c1cccc([14*])n1 ### Response: Cc1ccc(Cc2cccc([C@H]3CCCN3S(=O)(=O)c3cn(C)cn3)n2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(Cc1ccco1)C(=O)COc1ncnc2scc(-c3ccc(F)cc3)c12 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])[C@@H]1C[C@@H]2CC[C@H]1[NH+]2c1nc[nH+]c2c1CCCCC2 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(C(=O)N(C[C@@H]2CCCO2)C[C@H]2CN(C(=O)c3cccs3)CCO2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? CCCN(CC#N)C(=O)c1cc2c(cc1O)OCO2 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCN1C(=O)/C(=C\c2ccc(OC)c(OC)c2C(=O)[O-])S/C1=N\c1nccs1 ### Response: 3