task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a ester group? CCc1nnc(C[NH+](C)Cc2ccc(F)c(F)c2)o1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([16*])cc1 Fragment 2: [5*]NC=C1C(=O)OC(C)(C)OC1=O ### Response: Cc1cccc(C(=O)Nc2ccc(NC=C3C(=O)OC(C)(C)OC3=O)cc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)S(=O)(=O)c1ccc(OC(=O)c2cc(C3CC3)[nH]n2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])Cc1ccc(F)cc1 Fragment 2: [1*]C(=O)C[8*] ### Response: C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)C[C@@H]1SC(N)=NC1=O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(C(=O)[C@H]2CSCCS2)cc1C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@H]1CN(c2ccc(cc2)N)C[C@@H](C1)C ### Response: C[C@@H]1C[C@@H](C)CN(c2ccc(N)cc2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [5*]N[C@@H]1CCCc2ccc(Cl)cc21 ### Response: Clc1ccc2c(c1)[C@H](NCc1nc(C3CC3)cs1)CCC2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](CO)N/C=C1/C(=O)N(c2c(Cl)cccc2Cl)c2ccccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. N(CC)(CC)c1ccc(/C=C2\C([O-])=NC(=O)N(C2=O)c2c(cccc2)C)c(O)c1 ### Response: CCN(CC)c1ccc(/C=C2/C(=O)N(c3ccccc3C)C(=O)N=C2[O-])c(O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [5*]NCC[8*] ### Response: Cc1nc(S[C@@H](C)C(=O)NCCc2ccc(F)cc2)c2ccccc2n1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1cc2cccc(c2n1C)C)(N1C[C@H]2CCC[C@H](NC2=O)C1)=O ### Response: Cc1cccc2cc(C(=O)N3C[C@@H]4CCC[C@H](C3)C(=O)N4)n(C)c12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [14*]c1ccnn1C ### Response: COc1ccc(-c2cc(C(=O)N(C)Cc3ccnn3C)c3c(C)nn(C)c3n2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1cccc(C)c1N Fragment 2: [4*]C[C@@H]1CSc2ccccc21 ### Response: Cc1cccc(SC[C@@H]2CSc3ccccc32)c1N
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCn1nc(C(=O)N(C)[C@H]2C[C@@H](OCC)C23CCCC3)ccc1=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC([NH3+])(CC)CN1CCN(c2ccccc2)CC1 ### Response: 5
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH+](C)CCCNC(=O)/C=N/O ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@H](CC)[NH2+]C[C@H]1CC Fragment 2: [1*]C(=O)c1cscc1C ### Response: CC[C@H]1CN(C(=O)c2cscc2C)[C@H](CC)C[NH2+]1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CO[C@H]1CCCC[C@H]1NC(=O)N(C)CCOc1ccccc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? C[C@@H](NC[C@@H](O)c1ccccc1)c1ccncc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)=CC[NH+]1CCN(c2ccc(F)cc2)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? C/C(=N/NC(=O)c1ccccn1)c1ccccc1Cl ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCS(=O)(=O)N[C@H](C)CCc1ccccc1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cn1c(-c2ccco2)nn(C[NH+](C)CCc2ccccc2)c1=S ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1Oc1ncccn1)C[NH2+][C@H]1CN(C(=O)C1)CC(C)(C)C ### Response: CC(C)(C)CN1C[C@H]([NH2+]Cc2ccc(Oc3ncccn3)cc2)CC1=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC#CCN[C@@H](C)c1ccc(N2CCCC2=O)cc1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@@H](O)C[NH+](C)Cc1cnc2ccc(C)cn12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]([8*])C Fragment 2: [8*]CS(C)(=O)=O ### Response: C[C@H](NC(=O)c1cccc(CS(C)(=O)=O)c1)c1ccc(Cl)cc1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(C)cc1CN1CCN(S(=O)(=O)c2c(C)noc2C)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCn1c(SCn2cc([N+](=O)[O-])cn2)nnc1-c1csc(C)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCN1CCO[C@@H](c2noc([C@H]3C=C[C@@H]([NH3+])C3)n2)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1nc2cc(Cl)ccc2n1C Fragment 2: [1*]C(=O)[C@@H]([4*])C ### Response: Cc1cc(NC(=O)[C@H](C)Sc2nc3cc(Cl)ccc3n2C)no1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CC[C@@H]([15*])[C@H]1[13*] Fragment 2: [4*]Cc1ccccc1 ### Response: CCC[C@@H]1[C@H](C[C@@H](O)c2ccccc2)CC[NH+]1Cc1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(CC)c(-c2ccccc2)c2n(n1)c(C)c(CCC([O-])=O)c(C)n2 ### Response: CCc1nn2c(C)c(CCC(=O)[O-])c(C)nc2c1-c1ccccc1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1csc(CN(C)C(=O)c2cc(C[NH+](C)Cc3ccccc3)on2)n1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCc1cccc(C)n1 Fragment 2: [4*]Cc1cccc(C)n1 ### Response: Cc1cccc(COc2cccc(N)c2C)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc2cc([C@H](C)Nc3ccc(NC(C)=O)c(OC)c3)ccc2c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ncccc1CNS(=O)(=O)Cc1ccon1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [9*]n1nc([14*])ccc1=O ### Response: CCOc1ccc2nc(NC(=O)[C@H](C)n3nc(-c4ccc(C)cc4)ccc3=O)sc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCC[C@H]1C Fragment 2: [4*]CCCCN[5*] ### Response: C[C@@H]1CCCC[NH+]1CCCCNC(=O)c1ccc2c(=O)n(C)c(=O)n(C)c2n1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC[C@H]1C[C@@H](CC[C@@H]1[NH2+][C@H]1C(=O)N(CC1)c1n(C)nc(c1)C)C ### Response: CC[C@H]1C[C@H](C)CC[C@@H]1[NH2+][C@@H]1CCN(c2cc(C)nn2C)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. S1/C(=C/C2COc3ccccc3C=2)C(=O)N(c2ccccc2)C1=S ### Response: O=C1/C(=C\C2=Cc3ccccc3OC2)SC(=S)N1c1ccccc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CNc1nc([C@H]2CCCN(C(C)=O)C2)[nH+]c2c1CN(C(=O)Cc1ccc(C)c(C)c1)CC2 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/C=C(/C)C(=O)N[C@@H](C)c1ccc(OC(F)F)cc1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C[NH+]2CCN(CC(=O)N[C@H]3CCCC[C@@H]3C)CC2)no1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(Cn2nc(-c3cccs3)nn2)N(C(c2ccc(OCC)cc2)=O)CCC1 ### Response: CCOc1ccc(C(=O)N2CCC[C@@H]2Cn2nnc(-c3cccs3)n2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C2(Cc3cscn3)C[NH2+]C2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCCC1c1noc(n1)[C@H]1COc2ccc(cc2C1)F ### Response: Fc1ccc2c(c1)C[C@@H](c1nc(C3CCCCC3)no1)CO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(C(=O)[C@H](C)[S@@](=O)Cc1ccc(F)cc1F)c1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cn(CC)c(CNC(=O)N[C@@H](c2cccc(N3CCCC3)c2)C)n1 ### Response: CCn1cnnc1CNC(=O)N[C@H](C)c1cccc(N2CCCC2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nn(C)c(Cl)c1C[NH2+]Cc1cn2cccc(C)c2n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a carboxyl group? CC(=O)Nc1ccc(C)c(NC(=O)NCc2cccc(OCC(C)C)c2)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC(C)(C)C Fragment 2: [5*]Nc1ccc(C)cc1C ### Response: Cc1ccc(NC(=O)CC(C)(C)C)c(C)c1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@@H]1CC[C@@H](C)[NH+]([C@@H]2CCCC(C)(C)[C@@H]2[NH3+])C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1NC(=O)C[C@H](c1ccccc1C)n1cccc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1cnccc1SCC(=O)Nc1ccc(F)c(F)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc([C@H]2Nn3c(nnc3-c3ccccc3)S[C@H]2C(=O)N2CCOCC2)cc1Cl ### Response: Yes
functional_group
### Instruction: Does the molecule contain a phenol group? COc1cc2c(cc1OC)-c1n[nH]c(=O)cc1C2 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c12cc(ccc2[nH]c([C@@H]2N(CCCC2)C(C[NH+]2C[C@H](Oc3c(C2)cccc3)c2cscc2)=O)n1)F ### Response: O=C(C[NH+]1Cc2ccccc2O[C@H](c2ccsc2)C1)N1CCCC[C@@H]1c1nc2cc(F)ccc2[nH]1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C[NH+]2CCC(CNS(=O)(=O)c3ccc(C)c(C)c3)CC2)c(C)o1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1[nH]c2ccc(C(=O)N3CCN(c4cnn(-c5ccccc5)c(=O)c4Cl)CC3)cc2c1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/[NH+]=C(/NCc1ccnn1C)NCC(C)(C)[NH+]1C[C@H](C)C[C@@H](C)C1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)CN(C(=O)c1ccc(NN)nn1)C1CCCC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(Br)cc(C)c1NC(=O)N[C@@H](C)c1c(C)noc1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1([C@H](O)CNC(=O)CCc2c(F)c(F)ccc2)ccc(cc1)Cl ### Response: O=C(CCc1cccc(F)c1F)NC[C@@H](O)c1ccc(Cl)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c([C@H](O)CC([O-])=O)n(C(C)C)c2c1cc(Cl)cc2 ### Response: CC(C)n1c([C@H](O)CC(=O)[O-])nc2cc(Cl)ccc21
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1cccc(N2C[C@@H](NS(=O)(=O)c3cccnc3)CC2=O)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? Nc1c(-c2ccccn2)nsc1C(=O)NC1CCCC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? CC[C@@H](C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [4*]Cc1ccc(Cl)o1 ### Response: CCOc1ccc(C[NH2+]Cc2ccc(Cl)o2)cc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2ncsc2cc1C(=O)N1[C@H]2CC[C@@H]1CC(NC2)=O ### Response: O=C1C[C@H]2CC[C@@H](CN1)N2C(=O)c1ccc2ncsc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC([7*])C Fragment 2: [7*]C1C(=O)C[C@H]2[C@@H]1C2(C)C ### Response: CC[C@@H](C)N/C(C)=C1\C(=O)C[C@H]2[C@@H]1C2(C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@]1(c2c(F)cccc2F)NC(=O)N(CCn2cncn2)C1=O ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)CSC1=O Fragment 2: [1*]C(=O)C[8*] ### Response: O=C(Cc1ccc(-c2ccccc2)cc1)N[C@@H]1CCCC[C@@H]1N1C(=O)CSC1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Cn1cc(/C=C2\C(=O)Nc3cc(Cl)ccc32)c2ccccc21)NC[C@H]1CCCO1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)(c1onc(c1)NS(=O)(c1cn(nc1C)C)=O)(C)C ### Response: Cc1nn(C)cc1S(=O)(=O)Nc1cc(C(C)(C)C)on1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NC[C@H]1N=NC2=C1CCCCC2)[C@H]1CC=CCC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C Fragment 2: [5*][NH2+][C@@H](C)CC ### Response: CC[C@H](C)[NH2+]Cc1ccc(N(C)C)cc1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@@H]([NH2+]CC1(C)COC1)c1ccc2c(c1)NC(=O)CO2 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccco1)N1CCN(Cc2cc(=O)c(OCc3ccccc3F)co2)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(O/C(C1=O)=C\c1cccc(c1OC(=O)c1ccco1)OCC)cc(cc2)OC ### Response: CCOc1cccc(/C=C2\Oc3cc(OC)ccc3C2=O)c1OC(=O)c1ccco1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ncnc(N2CCCC[C@@H]2CCO)c1N ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cc2ncc3c(n2n1)-c1cc(C)ccc1OC3 Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: Cc1ccc2c(c1)-c1c(cnc3cc(-c4ccc(Cl)cc4)nn13)CO2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1COc2ccc3c(C)cc(=O)oc3c2C1 Fragment 2: [4*]CCC(C)C ### Response: Cc1cc(=O)oc2c3c(ccc12)OC[NH+](CCC(C)C)C3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCn1nc(-c2ccccc2)c2sc(N3CCCCC3)nc2c1=O ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitro group? CCNC(=O)C1(NC(=O)Cc2ccc(OC)c(F)c2)CCCCC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1OCCCNC(=O)c1cc(F)ccc1F ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(CC)N(C)S(=O)(=O)c1ccc(C)c(C(=O)OC)c1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]([NH3+])Cc1cccc(OC/C(Cl)=C/Cl)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Fc1ccc(C(F)(F)F)cc1C[NH+]1CCC(OC[C@H]2CCCO2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitrile group? O=C(c1ccoc1)N1CCO[C@@H](c2cccc(OC(F)F)c2)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)C(=O)N(c1nc2ccc(S(=O)(=O)C)cc2s1)Cc1cnccc1)C(C)(C)C ### Response: CC(C)(C)c1ccc(C(=O)N(Cc2cccnc2)c2nc3ccc(S(C)(=O)=O)cc3s2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. COc1c(C)cc(cc1C)CN(C)C(CCC1CCN(CC1)C(C)=O)=O ### Response: COc1c(C)cc(CN(C)C(=O)CCC2CCN(C(C)=O)CC2)cc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)C(=O)c1ccccc1NCC(=O)NC(=O)NC1CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1c(cc(cc1)F)Cl)Nc1cc(c(cc1)C(NC)=O)Cl ### Response: CNC(=O)c1ccc(NC(=O)c2ccc(F)cc2Cl)cc1Cl
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N21)C(C)C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1ccccc1F)c1ccc(CN2C(=O)CCC2=O)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)N[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@@H]1n1nc(-c2ccccc2)n(-c2ccccc2)c1=S ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc2ccccc2c(=O)[nH]1 Fragment 2: [8*]Cc1nc2ccccc2c(=O)[nH]1 ### Response: O=C1C2=C3CCCC[C@H]3SC2=NCN1Cc1nc2ccccc2c(=O)[nH]1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [7*]Cc1nc([14*])cs1 ### Response: N#Cc1ccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)cc1