task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](C)(NC(=O)N(C)C[C@H](O)C)CCC(C)C ### Response: CC(C)CC[C@H](C)NC(=O)N(C)C[C@@H](C)O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)c(OC)c1 Fragment 2: [1*]C(C)=O ### Response: COc1ccc(C(=O)c2ccc(OC(C)=O)cc2)cc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@H](NC(=O)c1ccccc1Cl)c1ccccc1)C(N1[C@@H]2[C@H](CCCC2)CCC1)=O ### Response: O=C(N[C@H](CC(=O)N1CCC[C@H]2CCCC[C@@H]21)c1ccccc1)c1ccccc1Cl
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](c1ccncc1)[C@H]([NH3+])C1CCCC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1ccc2c(c1)CC[C@H]1[C@](C)(C[NH2+]CCC[NH3+])CCC[C@@]21C ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)(CO)NC(=O)[C@H]1CC[C@H]2CCCC[C@@H]2[NH2+]1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(OCC(=O)N1CCOCC1)c1ccccc1F ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CNC(=O)c1cc([C@H]2CN(C(=O)COc3ccccc3)CCO2)nc2ccccc12 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(N(C[C@@H]1CNC(=O)CC1CCCC1)c1ccccc1)=O ### Response: O=C(CC1CCCC1)NC[C@@H]1CC(=O)N(c2ccccc2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc(CNC(=O)Cc2csc3nc(-c4ccc(F)cc4)cn23)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H]1CC(C)(C)CC[C@@H]1NC(=O)c1cnc([C@@H]2CCCO2)s1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(-c2nnc(NC(=O)c3ccc(C(C)(C)C)cc3)o2)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)C([NH2+][C@H]2CC[C@H]([NH3+])C2)C1(C)C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(OCC(=O)N1CCCCCC1)c1ccc(S(=O)(=O)N2CCOCC2)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCOc1ccccc1Cl)N1CCC[C@@H]2CCCC[C@H]21 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1c(cc(C(N2CCc3c(C2)sc(NC(c2sccc2)=O)n3)=O)cc1OC)OC)C ### Response: COc1cc(C(=O)N2CCc3nc(NC(=O)c4cccs4)sc3C2)cc(OC)c1OC
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#Cc1ccc(SC[C@H](O)CO)c(N)c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(cccc1)oc1c(=O)n(cnc21)CC(NC(=O)NCc1ccco1)=O ### Response: O=C(Cn1cnc2c(oc3ccccc32)c1=O)NC(=O)NCc1ccco1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)/C=C/N(C)[C@H]1CCC[C@@H](C)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@@H](C)CS(=O)(=O)Cc1ccccc1C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)c1cccc(NC(=O)c2ccc(Cn3nnc4ccccc4c3=O)cc2)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(CCC1C(Nc1oc(nn1)[C@H]1CCCO1)=O)S(=O)(=O)c1sc(Cl)cc1 ### Response: O=C(Nc1nnc([C@H]2CCCO2)o1)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. Nc1c(c(N2CCC(CC2)C(=O)OC)ncn1)N ### Response: COC(=O)C1CCN(c2ncnc(N)c2N)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CC[C@@H](S(NC(C)C)(=O)=O)C1)NCc1cn(nc1CC)C ### Response: CCc1nn(C)cc1CNC(=O)N1CC[C@@H](S(=O)(=O)NC(C)C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(NC(N([C@@H](CC)C)C)=O)cc(c1N1C(=O)CCC1)OC ### Response: CC[C@@H](C)N(C)C(=O)Nc1ccc(N2CCCC2=O)c(OC)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCc2c(nn(c2C1)CC(C)(O)C)C(OC)=O ### Response: COC(=O)c1nn(CC(C)(C)O)c2c1CCCC2
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc(-c2nnco2)cc1NC(=O)N1CCNC(=O)[C@@H]1C(C)C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(Br)c(F)ccc(c1)C[NH+]1C[C@@H](CO)CCC1 ### Response: OC[C@H]1CCC[NH+](Cc2ccc(F)c(Br)c2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C(CC)C[NH3+] Fragment 2: [8*]C(F)(F)F ### Response: CC/C(=C\c1cccc(C(F)(F)F)c1)C[NH3+]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [5*]NC(N[5*])=[NH+]C ### Response: C/[NH+]=C(/NC[C@H]([C@H]1CCOC1)N1CCOCC1)NC(C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)C1=C(N)Oc2cc(C)n(Cc3ccccc3)c(=O)c2[C@@H]1c1cccc(Cl)c1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(S(=O)(=O)NCc2ccc(C(=O)N(C)C)cc2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(N2CCCN(c3cc[nH+]c(C)c3)CC2)cc[nH+]1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](N(C)C(Nc1cccc(Cl)c1C)=O)(c1cccc(c1)O)C ### Response: Cc1c(Cl)cccc1NC(=O)N(C)[C@@H](C)c1cccc(O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nccs1 Fragment 2: [1*]C(=O)CS[11*] ### Response: O=C(CSCc1nc2sc3c(c2c(=O)[nH]1)CCCC3)Nc1nccs1
functional_group
### Instruction: Does the molecule contain a amide group? CN(C[C@@H]1CCCC[NH2+]1)C(=O)c1cccc2c1OCCO2 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(/C(=O)N(c2c(c(C)ccc2)C)C(S1)=S)=C/c1cc(F)ccc1 ### Response: Cc1cccc(N2C(=O)/C(=C\c3cccc(F)c3)SC2=S)c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)c(OC)c1 Fragment 2: [9*]n1cc([16*])cn1 ### Response: COc1ccc(-c2noc(-c3cnn(C4CCCCC4)c3)n2)cc1OC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCCSC[C@H]1CN1CCOCC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(/C=C\c1cn(C[C@@H](O)CN2CCc3ccccc32)c2ccccc12)c1ccccc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc(NC(=O)C[C@@H]2C(=O)N[C@H]3CCCC[C@@H]3N2C(=O)c2ccc(F)cc2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#Cc1cccc(NNC(=O)N[C@H](c2nccs2)C2CC2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc([N+](=O)[O-])ccc1C Fragment 2: [5*]N[C@H]1CCCn2nc(CC)nc21 ### Response: CCc1nc2n(n1)CCC[C@@H]2NC(=O)c1cc([N+](=O)[O-])ccc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1[C@@H]1C[C@@H]1/C([O-])=N/S(=O)(=O)c1cccc([N+](=O)[O-])c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCNC(=O)CCCC(=O)Nc1cc(-c2ccccc2C)nn1C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a phenol group? CCOC(=O)c1ccccc1NC(=O)c1ccc(N2CCCC2)nn1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(Br)cc(C)c1NC(=S)NC(=O)c1cccc2ccccc12 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1cccc(CO)c1)c1cn(Cc2ccccc2)nc1-c1ccc(Cl)cc1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCSC1=NC(=O)[C@@H]2C(=N1)N=C(C)/C(=C(\[O-])OC)[C@@H]2c1ccc(O)cc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*][NH+]1CCS[C@@H]([13*])C1 ### Response: CC(C)[C@H]1C[NH+](Cc2ncc(-c3cccs3)o2)CCS1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)C[C@@H]1CN(Cc2c(C)nn(CC(C)C)c2Cl)CCO1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? c1cnc2c(O[C@H]3CCC[NH2+]C3)cccc2c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ester group? CN(C)c1cccc(C(=O)Nc2cc(Cl)ccc2-n2cncn2)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NC(C)(Cc1c(C)cccc1)C)CSCC(F)(F)F ### Response: Cc1ccccc1CC(C)(C)NC(=O)CSCC(F)(F)F
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H]1CCC[C@H](Nc2cccnc2C)C1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@@H]1[NH2+]CC[C@@H]1C(=O)Nc1ccc(C(F)(F)F)cc1Cl ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(-c2nc3ccccc3s2)o1)/C=C1\SC(=S)N(C)C1=O ### Response: CN1C(=O)/C(=C/c2ccc(-c3nc4ccccc4s3)o2)SC1=S
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H](C)CC Fragment 2: [5*]N1CCN([5*])CC1 ### Response: CC[C@@H](C)C(=O)NCC(=O)N1CCN(CC(=O)NC2CCC(C)CC2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(F)(F)F Fragment 2: [16*]c1cc(N/N=C2/C(=[NH2+])N(C)N=C2[NH-])ccc1Cl ### Response: CN1N=C([NH-])/C(=N\Nc2ccc(Cl)c(C(F)(F)F)c2)C1=[NH2+]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc([16*])ccn1 Fragment 2: [4*]Cc1[nH]c([14*])c[nH+]1 ### Response: CSCc1ccnc(NCc2[nH]c(-c3ccccc3)c[nH+]2)c1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(Nc1cccc(N2CCCNC2=O)c1)C(=O)N1CCc2cc(F)ccc2C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? C/C(=N\Nc1c([N+](=O)[O-])c(C)nn1C)c1ccc(F)cc1F ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C)c(cc1)N1CCN(C(=O)c2cc(ccc2)OC)CC1=O ### Response: COc1cccc(C(=O)N2CCN(c3ccccc3C)C(=O)C2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCN(CC)[C@H](C[NH3+])c1ccc(C)o1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(CC)(CC(=O)NNC(=O)c1cc(C)oc1C)C(=O)[O-] ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COC(=O)c1ccccc1Br)c1ccc(Br)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[C@H]1CC[NH+](Cc2cccnc2Cl)C1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[C@@](C)(O)CNC(=O)C(=O)N1C[C@@H](C)Oc2ccccc21 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [16*]c1ccc([16*])c(C)c1 ### Response: CCOC(=O)N1CCN(C(=O)Nc2ccc(N(C)C)c(C)c2)CC1
functional_group
### Instruction: Does the molecule contain a amine group? COCCN(c1cc([C@@H](C)O)cc[nH+]1)[C@@H](C)C1CC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1cccc(-c2cnc3ccccc3n2)c1)c1cccc(NC(=O)c2ccco2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c2ccccc2nc(C([O-])=O)c1)Oc1ccc(cc1)C ### Response: Cc1ccc(Oc2cc(C(=O)[O-])nc3ccccc23)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c2c([nH+]c1C(=O)[O-])ccc(c2)F)N ### Response: Nc1cc(C(=O)[O-])[nH+]c2ccc(F)cc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)c(OC)c1 Fragment 2: [8*]CCc1ccc(OC)c(OC)c1 ### Response: COc1ccc(CCN2C[C@H](C(=O)Nc3ccccc3C)CC2=O)cc1OC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2nc(N3CCC[C@H]3C(=O)NCCCc3ccccc3)nc(C)c2c1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CCCC[NH+]1[5*] Fragment 2: [5*]NCCC[8*] ### Response: Cc1noc(CCCNC(=O)[C@@H]2CCCC[NH+]2Cc2ccncc2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(S(=O)(=O)N2C[C@H](C)[C@@H](C)C2)ccc1Br ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [4*]Cc1ccc(Cl)c(F)c1 ### Response: C[C@@H](CS(C)(=O)=O)NC(=O)N(C)Cc1ccc(Cl)c(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]C1CCN([5*])CC1 Fragment 2: [1*]C(=O)N1CCC([NH2+][5*])CC1 ### Response: CC(C)COC(=O)N1CCC([NH2+]Cc2nc(C(F)(F)F)cs2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(Cl)c(NC(=O)NCc2cn3ccsc3n2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)C1CC1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: [NH3+]CCN1CCN(S(=O)(=O)C2CC2)CC1
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1ccccc1CCC(=O)N1C[C@H]2C[C@@H]1C(=O)N2c1cc(C)ccc1OC ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OS(=O)(=O)c1ccc(S([12*])(=O)=O)cc1 Fragment 2: [5*]N1CCC[C@H](C)C1 ### Response: COc1ccc(OS(=O)(=O)c2ccc(S(=O)(=O)N3CCC[C@H](C)C3)cc2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCn1c(SCC(=O)NCc2ccc(F)cc2F)nc2ccsc2c1=O ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1CN(c2cc3c(cc2Br)C(=O)C(=O)N3)C[C@H](C)S1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCS[C@@H]1[13*] Fragment 2: [16*]c1cc(Br)ccc1OC ### Response: COc1ccc(S(=O)(=O)N2CCS[C@@H]2c2cc(Br)ccc2OC)cc1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCOC(=O)c1[nH]c(C)c(CCC(=O)N2CCN(c3ccccc3)CC2)c1C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1)[C@H]([C@H](CC)N1C[C@@H]2[NH+](CC1)CCCC2)[NH3+] ### Response: CC[C@@H]([C@H]([NH3+])c1ccccc1)N1CC[NH+]2CCCC[C@@H]2C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(F)cc(cc1)F)C1(CC1)CNC(=O)N1C[C@H]([NH+]2CCCC2)CC1 ### Response: O=C(NCC1(c2ccc(F)cc2F)CC1)N1CC[C@@H]([NH+]2CCCC2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[4*] Fragment 2: [4*]CC1CC1 ### Response: CN(CCOCC1CC1)c1ncccc1C[NH3+]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)NC(C)(C)C1=O Fragment 2: [8*]Cc1ccc([16*])cc1 ### Response: CC1(C)NC(=O)N(Cc2ccc(OC(F)(F)F)cc2)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc([C@H]2CCCN2C(=O)c2ccccc2I)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [5*]N([5*])C(C)C ### Response: CC(C)N(Cc1nc2ccccc2c(=O)[nH]1)C(=O)CCc1ccccc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(c(NC(Nc2ccc(cc2)C(=O)OCC)=O)c1)Cl)Cl ### Response: CCOC(=O)c1ccc(NC(=O)Nc2ccc(Cl)cc2Cl)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2c(CCN(C2)CC#CCNC(=O)NCCOC)cc1 ### Response: COCCNC(=O)NCC#CCN1CCc2ccccc2C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(CCC#N)C(=O)CCN1CCc2sccc2[C@H]1c1cccs1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc([14*])cs1 Fragment 2: [16*]c1ccc(OC)c(OC)c1 ### Response: COc1ccc(-c2csc(NC(=O)c3ccc(S(C)(=O)=O)cc3)n2)cc1OC
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[S@@](=O)c1ccc(CN2CCc3cc(Cl)cc(Cl)c3C2)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(N1c2ccc(cc2CC1)-c1ccc(cc1)C(NC1CC1)=O)CC ### Response: CCC(=O)N1CCc2cc(-c3ccc(C(=O)NC4CC4)cc3)ccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? OC[C@H]1O[C@@H](Oc2c[nH]c3ccccc23)[C@@H](O)[C@H](O)[C@@H]1O ### Response: 1