task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. O1CCC(C(=O)Oc2cc3c(cc2)OCO3)(CC1)c1ccccc1 ### Response: O=C(Oc1ccc2c(c1)OCO2)C1(c2ccccc2)CCOCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])c1ccc([16*])cc1 Fragment 2: [16*]c1ccccc1 ### Response: C[NH+]1CCC(NC(=O)CN(c2ccc(Oc3ccccc3)cc2)S(C)(=O)=O)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccncc1 Fragment 2: [14*]c1nc2ncc3c(=O)n(N4CC[NH+](C)CC4)ccc3n2n1 ### Response: C[NH+]1CCN(n2ccc3c(cnc4nc(-c5ccncc5)nn43)c2=O)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@@H]1CN(C(=O)[C@@H]2CCCN2C(=O)c2cccs2)CCO1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc([16*])c1 Fragment 2: [3*]OC(F)F ### Response: O=C(c1ccoc1)N1CCO[C@@H](c2cccc(OC(F)F)c2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1C[C@H]2CC[C@@H]1CN(C(c1ccccn1)=O)C2)CCc1n[nH]c(c1C)C ### Response: Cc1[nH]nc(CCC(=O)N2C[C@H]3CC[C@@H]2CN(C(=O)c2ccccn2)C3)c1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN1CCO[C@@H](COc2ccc(C(=O)[O-])cc2OC)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](O/N=C(/N)Cc1ccccc1)C(=O)Nc1ccc(F)c(F)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC1=C(N)C(=O)c2ncccc2C1=O ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccccc1C(=O)NNC(=O)NCC1(C)Cc2ccccc2C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1CCC([C@H]2OCCC[C@H]2C[NH2+]C(C)C)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cn(C)c2ccccc12 Fragment 2: [1*]C(=O)C[8*] ### Response: CN(C(=O)Cc1cn(C)c2ccccc12)[C@H]1CCc2ccccc2C1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1nnc(SCc2ccnc(Cl)c2)n1CC(N)=O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccn1)-c1ccc([C@@H](NC(=O)N[C@H]2CC[NH+](C2)CC2CC2)C)cc1 ### Response: C[C@H](NC(=O)N[C@H]1CC[NH+](CC2CC2)C1)c1ccc(-c2ccncc2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)[O-] ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc([16*])cc1 Fragment 2: [5*]N1CCN([10*])C(=O)[C@@H]([15*])C1 ### Response: C=CCN1CCN(Cc2ccccn2)C[C@H](Cc2ccc(-c3ccncc3)cc2)C1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1nccnc1N Fragment 2: [16*]c1cccc(Cl)c1 ### Response: Nc1nccnc1C(=O)NC1(c2cccc(Cl)c2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[C@@H](O)CCNC(=O)NCc1nc(-c2ccccc2)cs1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1[C@H](NC(CCc1oc(C)cc1)=O)C)N1CCOCC1 ### Response: Cc1ccc(CCC(=O)N[C@H](C)c2ccc(N3CCOCC3)cc2)o1
functional_group
### Instruction: Does the molecule contain a nitro group? CS(=O)(=O)[C@H]1CCC[C@@H](Nc2ccc(C#N)cc2[N+](=O)[O-])C1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](Oc1ccc(Cl)cc1N1C(=O)[C@@H]2[C@@H](C1=O)[C@H]1C=C[C@@H]2C1)C(=O)c1ccccc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)N1CCC[C@@H](Cc2ccc(NCCN3CCCC3=O)n[nH+]2)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Brc1cc(C[NH2+]CCSc2ccccc2)cs1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](c1ccc(c(c1)C)OC)([NH3+])[C@@]1(C)OCCC1 ### Response: COc1ccc([C@H]([NH3+])[C@]2(C)CCCO2)cc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)C(C[NH2+][C@@H]2CCC[C@@H]2[C@@H]2CCCC[NH2+]2)C1(C)C ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? CC(=O)c1ccc(OC(=O)[C@@H]2C[C@@H]2c2ccc(F)cc2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH2+]Cc1ccc(-c2cc(C)ccc2F)s1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? COc1ccc(NC(=O)C[C@H](C)[NH2+]C2CCC(O)CC2)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(F)c(C(N(CC)c2ccc(F)cc2)=O)c(F)ccc1N ### Response: CCN(C(=O)c1c(F)ccc(N)c1F)c1ccc(F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(C)n(CCCn2cc(-c3ccc(CO)o3)nn2)n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(c1cc(-c2ccc(C)o2)nc2c1cccc2)=O)c1cc(C)ccc1OC ### Response: COc1ccc(C)cc1NC(=O)c1cc(-c2ccc(C)o2)nc2ccccc12
functional_group
### Instruction: Does the molecule contain a ester group? [NH3+]Cc1ccc(C(=O)N2CCC(C(F)(F)F)CC2)o1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1c(NC(=O)[C@@H](C)n2c(C)cc(C)nc2=O)sc(C)c1C ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? CN(C(=O)CSc1nnc(-c2ccccc2F)n1C)[C@H]1CCCc2ccccc21 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@](C)(C1CCCCC1)NC(NCc1cc(on1)C)=O)O ### Response: Cc1cc(CNC(=O)N[C@@](C)(CO)C2CCCCC2)no1
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCC[C@H](CC(=O)OC)NC(=O)c1ccc(C#N)[n-]1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. [NH3+]Cc1cnn(Cc2ccccc2)c1C(F)(F)F ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc([C@](C)(O)CNC(=O)[C@H]2CCCN2C(=O)CC(C)(C)C)c(C)o1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H]1CN(Cc2cc(F)cc(C#CC[NH3+])c2)CC[NH+]1C ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1noc([14*])n1 Fragment 2: [5*]N1CCC([15*])CC1 ### Response: Cn1cc[nH+]c1CN1CCC(c2nc(-c3ccccn3)no2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C#C)cc(NC(=O)N[C@@H]2CCS(=O)(C2)=O)c1 ### Response: C#Cc1cccc(NC(=O)N[C@@H]2CCS(=O)(=O)C2)c1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1cc([C@H](C)NC(=O)NCCc2nnc3n2CCCCC3)c(C)s1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C1CC1)Oc1cc2c(cc1)C(=O)/C(=C/c1cc(ccc1OC)Br)O2 ### Response: COc1ccc(Br)cc1/C=C1\Oc2cc(OC(=O)C3CC3)ccc2C1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cncc([16*])c1 Fragment 2: [4*]Cc1cccn1C ### Response: Cn1cccc1CNc1cncc(-c2nncn2C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]COC Fragment 2: [3*]Oc1cccc([16*])c1 ### Response: CC[NH2+][C@@]1(CO)CCC[C@H](Oc2cccc(COC)c2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C#CCN(CC)C1CCC([NH3+])CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(NS(=O)(=O)c2cc(C(=O)NCc3ccc(Cl)cc3)ccc2C)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC[C@H](C[C@H](O)c2ccco2)N(C([C@@H]2[C@@H](C2)c2c(C)cccc2)=O)C1 ### Response: Cc1ccccc1[C@@H]1C[C@@H]1C(=O)N1CCCCC[C@@H]1C[C@H](O)c1ccco1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@H]([C@@H]1[C@@H](c2cc(ccc2)C(F)(F)F)C1)O ### Response: C[C@@H](O)[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1n[nH]c(C)c1NC(=O)NC1(c2ccc(F)cc2F)CCOCC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(CCOC2(CCC2)C1)n1ncc(C[C@H](CC)[NH3+])c1 ### Response: CC[C@H]([NH3+])Cc1cnn([C@H]2CCOC3(CCC3)C2)c1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1cc2c(c(=O)n1CC[NH+](C)C)[C@@]1(C(=O)N(CC(C)C)c3ccccc31)C(C#N)=C(N)O2 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? CCN(c1ccc(C(=O)N(C)C)cc1)S(C)(=O)=O ### Response: No
functional_group
### Instruction: Does the molecule contain a ester group? CCO[C@H](C)C(=O)OCC(=O)NC(C)C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. CC([C@@H](NC(=O)N[C@@H](c1ccc(Cl)cc1)CO)c1c(cccn1)C)C ### Response: Cc1cccnc1[C@H](NC(=O)N[C@H](CO)c1ccc(Cl)cc1)C(C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN[C@@]1(C(=O)[O-])CC[C@@H]([NH+]2CCC(C)(CC)CC2)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C(=O)CN2C(=O)c3ccccc3S2(=O)=O)c(C)n1-c1ccc2c(c1)OCO2 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)C[8*] Fragment 2: [12*]S(C)(=O)=O ### Response: C[C@@H](C[C@@H]1CCCC[NH2+]1)[NH2+]C1CCN(S(C)(=O)=O)CC1
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)N(CC(F)(F)F)C(=O)N(CC(=O)[O-])C(C)(C)C ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(C(=O)CNc2cccc3c2CCCC3)C[C@@H](C)O1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nn(-c3ccccc3)cc2C(=O)Nc2nnc[nH]2)cc1OC ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1ccnc1[C@@H](NC(=O)c1nccc2ccccc12)c1ccc(F)c(F)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(C)c1CC(=O)N[C@@H]1CCCN(c2cc(N(C)C)ncn2)C1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCN(CC(C)(C)C[NH3+])c1ncnc2ccsc12 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(=C(C(OCC)=O)[C@H](CC(N1)=O)c1ccc([N+]([O-])=O)cc1)C(F)(F)F ### Response: CCOC(=O)C1=C(C(F)(F)F)NC(=O)C[C@@H]1c1ccc([N+](=O)[O-])cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(C)c1[C@H](C)NC(=O)CCc1nncn1-c1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC([15*])CC1 Fragment 2: [5*]N1CC[NH+]([5*])C[C@H]1[13*] ### Response: Cc1cc(F)ccc1N1CCC([NH+]2CCN(C(C)C)[C@H](CCO)C2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H](C)N[5*] Fragment 2: [15*]C1CCCC1 ### Response: COc1ccc(/C=C/C(=O)N[C@@H](C)C(=O)N(C2CCCC2)C2CC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN1C[C@H](C(=O)NCc2ccncc2)CC1=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#C[C@H](COC(=O)[C@@H]1Cc2ccccc2C(=O)O1)Cc1ccccc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? O=C([O-])c1nc2ccc(Cl)cc2cc1F ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1c2n(c(-c3cccc(c3)NS(=O)(c3ccccc3)=O)nn2)CCCC1 ### Response: O=S(=O)(Nc1cccc(-c2nnc3n2CCCCC3)c1)c1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(C)c1cccc(NC(=O)NC[C@H]2COc3ccccc3O2)c1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C2=NN(C(=O)COc3ccc([N+](=O)[O-])cc3)[C@H](c3ccco3)C2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC/[NH+]=C(\NC[C@H]1CCCO1)NC[C@H](C)C#N ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(NC([C@H](C)Nc2ccc(N3C(OCC3)=O)cc2)=O)cc1F ### Response: C[C@H](Nc1ccc(N2CCOC2=O)cc1)C(=O)Nc1cccc(F)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Cc1cc(Cl)c2c(c1)OCCCO2)Nc1cccc(-c2nnnn2C2CC2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC=C Fragment 2: [5*]N([5*])CC=C ### Response: C=CCN(Cc1cccc(C#N)c1)C(=O)Nc1ccc(OC(F)(F)F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1csc(NC(=O)c2cnc3sccn3c2=O)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a thiol group? [NH3+][C@@H]1CCC[C@H](Oc2ccccc2C(F)(F)F)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(Cc2noc(-c3ccc(-c4ccc(OC)nc4)nc3)n2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C([C@@](C)([NH3+])CC)=O)c1c(C[NH+](CC)CC)cccc1 ### Response: CC[NH+](CC)Cc1ccccc1NC(=O)[C@@](C)([NH3+])CC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnc2ccccc21 Fragment 2: [14*]c1ccc([16*])cn1 ### Response: O=C([O-])c1ccc(-n2cnc3ccccc32)nc1
functional_group
### Instruction: Does the molecule contain a thiol group? Cn1c(=O)[nH]c2cc(C(=O)Nc3ccc(NC(=O)OC(C)(C)C)cc3)ccc21 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1-c1ccccc1)NC(=O)N[C@@H]1[C@@H](C(N)=O)CCCC1 ### Response: NC(=O)[C@H]1CCCC[C@@H]1NC(=O)Nc1ccc(-c2ccccc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(CCNC(=O)c2cnn(-c3ccc(Br)cc3)c2C)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1[NH2+]CC[C@H]1C(=O)N1CCC(C(=O)[O-])CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccccc1NC(=O)CSc1ncnc2c1cnn2-c1ccccc1C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc(Cl)ccc1[N+](=O)[O-] Fragment 2: [14*]c1ccccn1 ### Response: CC(C)[C@@H](NC(=O)c1cc(Cl)ccc1[N+](=O)[O-])c1ccccn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCc1ccc(C(=O)N(C)c2ccc(Oc3ccccc3)cc2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C)c2[nH]c(=O)c(cc2c1C)CN(S(=O)(=O)c1ccc(cc1)F)Cc1ccc(cc1)C ### Response: Cc1ccc(CN(Cc2cc3c(C)ccc(C)c3[nH]c2=O)S(=O)(=O)c2ccc(F)cc2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1c2c(cc(C)o2)[C@H](NC(N2CCN(CC2)c2ncccn2)=O)CC1(C)C ### Response: Cc1cc2c(o1)CC(C)(C)C[C@H]2NC(=O)N1CCN(c2ncccn2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@@H]1CCO[C@@H]1[13*] Fragment 2: [16*]c1ccccc1 ### Response: C[C@H]1CCC[C@@H](N(C)C(=O)NC[C@@H]2CCO[C@@H]2c2ccccc2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CSCN1[5*] Fragment 2: [5*]N(C)C[8*] ### Response: CO[C@H](C)C(=O)N1CSC[C@@H]1C(=O)N(C)Cc1ccco1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C)c2[nH]c(=O)c(CN(CCC[NH+](C)C)C(=O)Nc3ccc(F)cc3)cc12 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [5*]NCc1cccc(OC)c1O ### Response: COc1cccc(CNC(=O)Cc2cccc(F)c2F)c1O
functional_group
### Instruction: Does the molecule contain a carboxyl group? O=C(COc1ccc(I)cc1)N[C@H]1CCOc2ccc(Br)cc21 ### Response: No
functional_group
### Instruction: Does the molecule contain a amine group? C[C@H]1CCCN(S(=O)(=O)NCc2cccnc2-n2cncn2)C1 ### Response: Yes