task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [5*]Nc1ncnc2c1CCCCC2 ### Response: CC[C@H](Nc1ncnc2c1CCCCC2)c1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc([N+](=O)[O-])cc1 Fragment 2: [5*][NH+]1CCC[C@H]1[13*] ### Response: Cc1cccc([C@@H]2CCC[NH+]2Cc2ccc([N+](=O)[O-])cc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNC(=O)c1cccc(CNC(=O)[C@H]2COc3ccccc3C2)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Nc1ccc2oc(CSCCO)nc2c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CNC(=O)N1CCO[C@H](c2ccccc2)C1)c1ccsc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amine group? CNC(=O)c1nn(CCc2ccccc2)c2c1C[C@@H](N1CCOc3ccc(Cl)cc3C1)CC2 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(COc1ccc(Br)cc1)NC(=S)Nc1ccc(Cl)cc1C(=O)[O-] ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[C@H](NC(=O)Nc1ccccc1)C(=O)Nc1nccs1 ### Response: 5
functional_group
### Instruction: Does the molecule contain a ether group? O=C(COC(=O)c1ccc(Cl)nc1)NC(=O)Nc1ccc2c(c1)OCCO2 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc([C@@H](O)[C@H](C)NC(=O)C[C@H](C)c2cccc(F)c2)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(=O)N(CC(Nc2c(cccc2C(C)C)C(C)C)=O)C([C@](CC)(N1)c1ccc(Cl)cc1)=O ### Response: CC[C@]1(c2ccc(Cl)cc2)NC(=O)N(CC(=O)Nc2c(C(C)C)cccc2C(C)C)C1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)NC(=O)N(CC(=O)NCCc2cn3ccccc3[nH+]2)C1=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ncc(C)s1 Fragment 2: [5*]N[C@H]([8*])C ### Response: Cc1cnc([C@H](C)NC(=O)N[C@@H](C)c2ccc3c(c2)OCO3)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [4*]CC(=C)C ### Response: C=C(C)CN(CC)C(=O)CS/C(N)=N/c1ccccc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C=CCCC[C@@H](C)[NH+]1CCC(NC(=O)c2ccoc2C)CC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. NC(=O)C1CC[NH+](C/C=C/c2ccccc2)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nncs1 Fragment 2: [1*]C(=O)c1ccc([16*])cc1 ### Response: O=C(Nc1nncs1)c1ccc(N2CCCCC2=O)cc1
functional_group
### Instruction: Does the molecule contain a phenol group? CC[C@H]([NH2+][C@@H](C)c1ccccc1N(C)C)c1c(C)noc1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]COC Fragment 2: [3*]Oc1ccc(N[5*])cn1 ### Response: COCc1cc(C(=O)Nc2ccc(Oc3ccc(C)cc3)nc2)no1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(=O)oc2cc(OC)ccc12 Fragment 2: [8*]Cn1nc([14*])oc1=O ### Response: COc1ccc2c(Cn3nc(-c4ccco4)oc3=O)cc(=O)oc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1ccco1 Fragment 2: [3*]OCC1=NC(=O)C2=C3CCCC[C@H]3SC2=N1 ### Response: O=C(/C=C/c1ccco1)OCC1=NC(=O)C2=C3CCCC[C@H]3SC2=N1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(CCN1Cc1ccccc1C)c1n(cc[nH+]1)C ### Response: Cc1ccccc1CN1CCN(c2[nH+]ccn2C)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1CN(C(=O)C2CCN(S(=O)(=O)c3ccc(Cl)c(C(F)(F)F)c3)CC2)C[C@H](C)O1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. CCNC(=O)[C@@H](n1c2ncc(cc2nc1[C@@H](C)Cl)C)C ### Response: CCNC(=O)[C@H](C)n1c([C@@H](C)Cl)nc2cc(C)cnc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCNC(=O)c1ccc(NC(=O)Cn2ncc3ccccc3c2=O)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? O=C(Nc1ccc(C(F)(F)F)cc1)c1ccc(NCc2ccccc2)nc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)(c1ccc(c(c1)[N+](=O)[O-])NC[C@H]([NH+](C)C)c1ccco1)F ### Response: C[NH+](C)[C@@H](CNc1ccc(C(F)(F)F)cc1[N+](=O)[O-])c1ccco1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [1*]C(=O)N[5*] ### Response: Cc1cccc(NC(=O)NCC(=O)Nc2cc(C)ccc2F)c1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1ccc(-n2nc(C)c3c2C[C@H](c2cc(OC)c(OC)c(OC)c2)CC3=O)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccc(CCl)cc1OCc1nccs1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nnc(=O)[nH]c1N/N=C/c1cccc(OC(C)C)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H](C)[C@@H](O)CSc1cccc(Br)c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCC1CC1 Fragment 2: [8*]CCC1([15*])CCC([15*])CC1 ### Response: CCCCC1CCC(CCC2CC2)(C(=O)[O-])CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1CCN(C(=O)NCCc2nnc3n2CCCCC3)[C@@H](C)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(-c2ccccc2)on1)C[S@](Cc1oc(C)cn1)=O ### Response: Cc1cnc(C[S@](=O)Cc2cc(-c3ccccc3)on2)o1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CCn1cnc2c([nH]c3ccc(F)cc32)c1=O)NC1CCCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]Nc1cnn([9*])c1 ### Response: COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(S(=O)(=O)N(C)CC(=O)NCc2ccc(C)cc2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(Nc1c(Cl)c(ccc1)C)N1CCN(CC1)C(=O)CC1CCCCC1 ### Response: Cc1cccc(NC(=O)N2CCN(C(=O)CC3CCCCC3)CC2)c1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C)c(N(C)C(=O)c2cnc(N3CCOCC3)c3ccccc23)c1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]S[C@@H]1CCCc2ccccc21 Fragment 2: [8*]CCC(N)=O ### Response: Cn1c(CCC(N)=O)nnc1S[C@@H]1CCCc2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCC[C@@H]([NH2+][C@@H](C)c1ccc(F)cn1)c1ccccc1 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(C)cc1 Fragment 2: [5*]Nc1ccc2c(c1)OCO2 ### Response: Cc1ccc(C(=O)Nc2c(C(=O)Nc3ccc4c(c3)OCO4)oc3ccccc23)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCNC(=O)c1cnn(-c2ccc(F)cc2)c1CC ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c[nH+]c(NCCC(=O)Nc2nccs2)nc1N(C)C ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1[C@@H](C)CCC[C@H]1NC(=O)C(=O)Nc1ccc(Oc2cccnc2)nc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ccccc2NC(=O)C(C)(C)N1C([C@@H](SCc1cc(ccc1OCC)C(C)=O)C)=O ### Response: CCOc1ccc(C(C)=O)cc1CS[C@@H](C)C(=O)N1c2ccccc2NC(=O)C1(C)C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)N(CCC#N)CC2CC2)c(Cl)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](C[C@H]([NH+]2CCCC2(C)C)C1)[NH2+]CC ### Response: CC[NH2+][C@H]1CC[C@@H]([NH+]2CCCC2(C)C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. S=C(n1nc(c2[C@H]3[C@@H](Cc21)C3(C)C)C)NC ### Response: CNC(=S)n1nc(C)c2c1C[C@@H]1[C@H]2C1(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CC[C@]2(C)[C@@H](CC[C@@H](O)[C@H]2[15*])[C@]1(C)CO Fragment 2: [5*]Nc1ccccc1 ### Response: C[C@]1(CO)[C@@H]2CC[C@@H](O)[C@@H](CC(=O)N3CCCC3)[C@]2(C)CC[C@H]1OC(=O)Nc1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(CNC(=O)NCc2ncoc2C)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(/c1cn(Cc2ccc(F)cc2)c2ccccc12)=C(\C#N)C(Nc1ccccc1)=O ### Response: N#C/C(=C/c1cn(Cc2ccc(F)cc2)c2ccccc12)C(=O)Nc1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[NH+](CC(=O)N(CC)Cc1sc(Br)cc1)CC([O-])=O ### Response: CCN(Cc1ccc(Br)s1)C(=O)C[NH+](C)CC(=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccc(CCNC(=O)NCCC(=O)N(C)C)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](CN[C@H](C)c1cnc2cc(C)nn2c1C)[NH+]1CCc2ccccc2C1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CS(=O)C[8*] Fragment 2: [14*]c1nc(C)cs1 ### Response: Cc1csc(C[S@](=O)Cc2csc(-c3ccccc3F)n2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(C(=O)N2CCN([C@H](C#N)C(C)C)CC2)c(C)n(n1)CCC ### Response: CCCn1nc(C)c(C(=O)N2CCN([C@H](C#N)C(C)C)CC2)c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]([8*])O Fragment 2: [15*]C1CCOCC1 ### Response: CC1(C)CC[C@H](NC(=O)NC[C@@H](O)C2CCOCC2)c2ccccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. C1COCCN1c1cc(c(cc1)NS(=O)(=O)c1ccccc1C)C(=O)[O-] ### Response: Cc1ccccc1S(=O)(=O)Nc1ccc(N2CCOCC2)cc1C(=O)[O-]
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COCCNC(=O)N1CCC[C@@H](c2nnc(C(=O)Nc3cccc(Cl)c3)s2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@H]2C[C@H]([C@@H]3[C@@H]2CCC3)[C@H]1[NH2+][C@H](CO)C ### Response: C[C@@H](CO)[NH2+][C@H]1C[C@H]2C[C@@H]1[C@H]1CCC[C@H]21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1ccc(NC(=O)c2n[nH]c(C(C)C)n2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)OC)NC([C@H](NC(c1ccc(cc1)Cl)=O)CC(C)C)=O ### Response: COc1ccc(NC(=O)[C@@H](CC(C)C)NC(=O)c2ccc(Cl)cc2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [1*]C(=O)C(C)C ### Response: CC(C)C(=O)N1CCN(S(=O)(=O)c2cccc(Br)c2)CC1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H](NC(=O)Nc1cnc(C(C)(C)C)nc1)C(=O)NC(C)(C)C ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCc1ccccc1)/N=C1/S[C@H]2CS(=O)(=O)C[C@H]2N1c1ccccc1Cl ### Response: 2
functional_group
### Instruction: Does the molecule contain a phenol group? O=C1N[C@@H](c2cccc3c2OCO3)N2CCCC[C@H]12 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CCC[C@@H]([15*])C1=O Fragment 2: [14*]c1ccn(C)n1 ### Response: Cc1ccc2c(c1C)[C@@H](N[C@@H]1CCCN(c3ccn(C)n3)C1=O)CCO2
functional_group
### Instruction: Does the molecule contain a carboxyl group? CC(C)=C1[C@H]2CC[C@@H]1[C@H]1C(=O)N(NC(=O)COc3ccc(Cl)c(C)c3)C(=O)[C@@H]12 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)[C@@]1(NC2CCCC2)CCCS[C@H]1C ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#Cc1ccc(C(=O)NCC(=O)N2CCC[C@H]3CCC[C@@H]32)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCCN(C(=O)[C@H]1CC=CCC1)[C@@H]1CCS(=O)(=O)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](O)Cn1c([C@H]2CCC[NH2+]2)nc2cc(C(F)(F)F)ccc21 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CCN1C(=O)[C@@H](CC(=O)Nc2cccc(OC)c2)S/C1=N\S(=O)(=O)c1ccc(Cl)s1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [4*]Cc1cccnc1C ### Response: Cc1ncccc1CN(C)Cc1ncnn1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1csc2[nH+]c(CN3CCC[C@@H](C(=O)Nc4cnccn4)C3)cc(=O)n12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? COc1ccc(S[C@H](C)C(=O)N(C)c2cccnc2N(C)C)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? CN(C(=O)c1ccn(C)n1)[C@H](Cc1ccccc1)C1CCN(C(=O)C2=CCCC2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N/C=C1\C(=O)NC(=S)N([10*])C1=O Fragment 2: [16*]c1ccccc1F ### Response: Cc1c(N/C=C2\C(=O)NC(=S)N(c3ccccc3F)C2=O)c(=O)n(-c2ccccc2)n1C
functional_group
### Instruction: Does the molecule contain a ether group? COc1cc(CNC(=O)c2occc2Br)ccn1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)[C@@H]3C[C@@H]3C)CC2)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc([C@@H](C)N[C@@H](c2nc(C3CC3)no2)C(C)C)o1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH2+][C@H]1CCC[C@@H](N2CC[C@H]([NH+](C)C)C2)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C(=O)c1ccsc1)[C@@H](Cc1ccccc1)C1CCN(C(=O)c2ccc[n+]([O-])c2)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)[C@]1(C)[NH2+][C@@H](c2ccc(C(C)C)cc2)[C@H]2C(=O)N(CC)C(=O)[C@@H]21 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(c(Cl)c(CO)c(n1)CCC)-c1ncncc1 ### Response: CCCc1nn(-c2ccncn2)c(Cl)c1CO
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H]([C@@H]1C(=O)N1CC(C)(C)[S@](=O)CC1)c1c(Cl)cccc1 ### Response: CC1(C)CN(C(=O)[C@@H]2C[C@@H]2c2ccccc2Cl)CC[S@]1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(COc1ccc([N+](=O)[O-])cc1Cl)NC1CCCCCCC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NCCS(=O)(=O)c1ccccc1)N1CCC[C@@H]2CCC[C@@H]21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C=CCn1c(SCC(=O)c2c[nH]c3ccccc23)nc2scc(C3CC3)c2c1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? O=C(c1cnc([C@H]2CCCO2)s1)N1CCOc2c(Cl)cccc21 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOC(=O)C1CC[NH+](Cc2oc(CO)cc(=O)c2[O-])CC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)(CN1C[C@H](OCC1)CNC(=O)N1CCN(C([C@H]2C[C@H]2C)=O)CC1)C ### Response: CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H]1CCC[C@]2(CC[NH2+]C[C@@H]2c2cccc(Br)c2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccc1 Fragment 2: [16*]c1cc(Br)cc2cccnc12 ### Response: Cc1ccc(C(=O)Nc2ccccc2)cc1S(=O)(=O)Nc1cc(Br)cc2cccnc12
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](CCc1ccccc1)NC(=O)N1CCC[C@H](CN2CCOCC2)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? O=C(NCC[C@H](O)c1ccccc1)Nc1ccccc1N1CCCC1=O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ester group? CCCS(=O)(=O)CC(=O)N[C@@H](C)Cc1c(Cl)cccc1Cl ### Response: No