task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](C)[C@@H](CNC(=O)[C@@H]1CC(=O)N(Cc2ccccn2)C1)c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CC[NH+]1C(C)C)N(C(c1ccc(cc1)-n1cccc1)=O)C ### Response: CC(C)[NH+]1CCC(N(C)C(=O)c2ccc(-n3cccc3)cc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1OCC[C@H]1C(=O)N1CCN(S(=O)(=O)c2cccc(F)c2)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCCN(C)C(=O)C1(CC)CCCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [4*][C@@H]([8*])CCO ### Response: OCC[C@@H]([NH2+][C@H]1CCCc2ccc(Cl)cc21)C1CC1
functional_group
### Instruction: Does the molecule contain a nitrile group? CCc1nnc(N2CCN(C(=O)Cc3cccc(OC)c3)CC2)c2cccn12 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1N1CCN(C(=O)c2cccc(S(=O)(=O)N3CCOCC3)c2)CC1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Clc1nnc(SC2COC2)c2ccccc12 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1F Fragment 2: [5*][NH2+]CC ### Response: CC[NH2+]Cc1ncoc1-c1ccc(F)cc1F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#CCC1(CSc2cc3ccccc3[nH]2)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. NC1=[NH+]C[C@](c2ccc(C(C)(C)C)cc2)(N1CC1CC1)C ### Response: CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@H](C)O[C@@H](CN1C[C@H]1C(=O)O[C@@H]2CC3[C@](C)([C@@H]([C@H]12)O)[C@H](C)CCC=3)C ### Response: C[C@@H]1CN(C[C@H]2C(=O)O[C@@H]3CC4=CCC[C@@H](C)[C@@]4(C)[C@H](O)[C@@H]32)C[C@H](C)O1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1n(c(nn1)CSCc1nnnn1-c1c(C)cccc1C)C ### Response: Cc1cccc(C)c1-n1nnnc1CSCc1nnc(C)n1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [5*]Nc1sc2ccccc2c1Cl ### Response: CCOC(=O)[C@@H](C)CNC(=O)Nc1sc2ccccc2c1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(Br)cc1F Fragment 2: [3*]Oc1ccc(Br)cc1F ### Response: Cc1cc(Oc2ccc(Br)cc2F)c([C@H](C)[NH3+])cc1F
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@H](Cc1ccc(C)cc1)NC(=O)NNC(=O)Nc1ccccc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C[NH+]2[C@@H](C)C[C@H](C2)NCc2cn(C)nc2C(C)(C)C)cccc1 ### Response: C[C@H]1C[C@@H](NCc2cn(C)nc2C(C)(C)C)C[NH+]1Cc1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=CCCO[C@H](C)C(=O)N[C@@H]1CC[NH+](C)[C@@H]1c1ccc(Cl)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)c1c(C)noc1C Fragment 2: [16*]c1cc(C)ccc1OC ### Response: COc1ccc(C)cc1-n1ccc(C(=O)N(C)c2c(C)noc2C)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(/C=C/c1ccc(N2CCCC2=O)cc1)NCC(=O)Nc1cccnc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)NC(=O)[C@@]1(Cc2ccccc2-c2cccs2)CCC[NH+](Cc2cnc(N)nc2)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [5*]N[C@H]1CC[C@]2(C)CC[C@H]([15*])[C@H](O)[C@H]2[C@@H]1C ### Response: CC1CCN(C(=O)[C@@H](C)[C@H]2CC[C@@]3(C)CC[C@H](NC(=O)Cc4ccccc4)[C@@H](C)[C@@H]3[C@H]2O)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCO[C@H]([13*])C1 Fragment 2: [4*]Cc1c(C)nc2sccn12 ### Response: Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. ClC1(Cl)[C@@H](c2ccccc2)[C@@H]1c1ccccc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(C)C Fragment 2: [14*]c1c(Cl)c(C)nn1C ### Response: Cc1nn(C)c(C[C@@H](O)c2ccc(CC(C)C)cc2)c1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C(=O)Nc2ccc(NC=C3C(=O)OC(C)(C)OC3=O)cc2)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(C(=O)Nc2ccc(-n3ncn(C)c3=O)cc2)c(C)n1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CCN1CCOCC1)[NH2+][C@H]1CCc2cc(Br)ccc2C1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Fc1cc(C[NH2+]CCCn2cc[nH+]c2)cc(F)c1F ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(S(=O)(N2CC[NH2+][C@H](C)C2)=O)nccc(C#N)c1 ### Response: C[C@@H]1CN(S(=O)(=O)c2cc(C#N)ccn2)CC[NH2+]1
canonicalization
### Instruction: Canonicalize the following SMILES string. NC(=S)COc1ccc(cc1)NC(c1ccc(cc1)F)=O ### Response: NC(=S)COc1ccc(NC(=O)c2ccc(F)cc2)cc1
functional_group
### Instruction: Does the molecule contain a nitrile group? CN(C(=O)N[C@H]1CC[C@@H]([NH+](C)C)C1)[C@@H]1CCN(c2ccccc2F)C1=O ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#Cc1ccc(OC2CCC(NC(=O)c3ccc[nH]3)CC2)nc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c(CNc2cc(OC)c(cc2)OC)cc1)Br ### Response: COc1ccc(NCc2ccccc2Br)cc1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc(Cl)cn1 Fragment 2: [8*]C[C@H]([8*])[NH3+] ### Response: COc1cccc(C[C@@H]([NH3+])c2ccc(Cl)cn2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])S(=O)(=O)c1ccccc1Br Fragment 2: [4*]CC1CC1 ### Response: CC(C)N(CC1CC1)S(=O)(=O)c1ccccc1Br
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(CC)(CC)CC Fragment 2: [5*]N[C@@H](C)CSC ### Response: CCC(CC)(CC)NC(=O)N[C@@H](C)CSC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1Br Fragment 2: [3*]Oc1ccc([N+](=O)[O-])c(N)n1 ### Response: Nc1nc(Oc2ccc(F)cc2Br)ccc1[N+](=O)[O-]
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(/C=C/c1ccc(Cl)cc1)OCC1CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)c(F)c1 Fragment 2: [4*][C@@H](C)c1ccc(F)c(F)c1 ### Response: C[C@@H](c1ccc(F)c(F)c1)[NH+](C)Cc1cn2cc(Cl)ccc2n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cscc1[C@H]([NH3+])c1cc(F)cc(F)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(C)cc(cc1C)Br)NC(N[C@H](CCO)CSC)=O ### Response: CSC[C@@H](CCO)NC(=O)Nc1c(C)cc(Br)cc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(C)c2occ(C(C)=O)c2c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1ccc(C[C@H](C)[NH2+]Cc2ccc(NC(=O)N)cc2)cc1 ### Response: C[C@@H](Cc1ccc(Cl)cc1)[NH2+]Cc1ccc(NC(N)=O)cc1
functional_group
### Instruction: Does the molecule contain a ether group? COC(=O)c1cccc(-c2ccc(/C=C3/NC(=O)N(Cc4ccccc4F)C3=O)o2)c1C ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(CNC(=O)[C@H](C)Oc2ccc(C#N)cc2)cc1OC ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)C(=O)Cc1cn(Cc2ccc(Cl)cc2)c2ccccc12 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CN(CC1CC[NH+](C)CC1)C(=O)c1cccc(-c2noc(C3CC3)n2)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]([8*])CC Fragment 2: [4*]CC=C(C)C ### Response: CC[C@H](NC(=O)c1ccccc1SCC=C(C)C)c1nccs1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(C[C@@H](O)c2ccccc2Cl)CCN1S(=O)(C)=O ### Response: CS(=O)(=O)N1CCN(C[C@@H](O)c2ccccc2Cl)CC1
functional_group
### Instruction: Does the molecule contain a aldehyde group? O=Cc1ccc(N2CCC[C@@H](c3nc4ccccc4[nH]3)C2)c([N+](=O)[O-])c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NC(Cn2cc([nH+]c2)-c2nc(C3CC3)on2)=O)ccc(c1Cl)OC ### Response: COc1ccc(NC(=O)Cn2c[nH+]c(-c3noc(C4CC4)n3)c2)cc1Cl
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=S(=O)(c1ccc(Br)cc1Cl)N1CCN(Cc2cc(-c3ccccc3)no2)CC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(Nc1ccc(Cl)cc1)C(=O)[O-] ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCNC(=O)N[C@H](C)c1cc(OC)c(OC)c(OC)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(C)(C)NC(=O)[C@@H](C)N1CCN(c2ccc(OC)c(F)c2)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])C(C)C Fragment 2: [16*]c1cccc(Cl)c1 ### Response: Cc1c(C(=O)N(CC(N)=O)C(C)C)nnn1-c1cccc(Cl)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCn1cnnc1S[C@H]1C[C@@H](C)OC1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccnc1C[C@H]([NH3+])[C@H]1C[C@@H]1C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1CN(C(=O)c2cnn3cccnc23)C[C@H](OCc2cccnc2)CN1CC1CCOCC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)(c1ccc(-c2ocnc2C[NH2+]C)cc1)F ### Response: C[NH2+]Cc1ncoc1-c1ccc(C(F)(F)F)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCC[C@H]1CO Fragment 2: [15*][C@@H]1CCOC2(CCSCC2)C1 ### Response: OC[C@@H]1CCC[NH+]1[C@@H]1CCOC2(CCSCC2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC([6*])=O Fragment 2: [3*]Oc1ccc(F)cc1Br ### Response: O=C(COc1ccc(F)cc1Br)c1cccc(Br)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. CCS[C@H]1C[C@H](CCC1)NC(=O)N[C@@H](C)c1c(noc1C)C ### Response: CCS[C@@H]1CCC[C@H](NC(=O)N[C@@H](C)c2c(C)noc2C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCSC1(CNC(=O)Nc2cc(-c3ccccc3)on2)CCOCC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(C(=O)C2(C#N)CCCC2)CCC1n1c2c(cccc2)[nH]c1=O ### Response: N#CC1(C(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C1CCN(S(=O)(=O)c2cccs2)CC1)N1CCN(Cc2cccc3ccccc23)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc([14*])c([N+](=O)[O-])c(C)n1 Fragment 2: [16*]c1ccccc1O ### Response: Cc1nc(Nc2ccccc2O)nc(N(C)c2ccccc2)c1[N+](=O)[O-]
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](Cc1cccs1)C(=O)NCCN1C(=O)CCCC1=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@](O)(c1cc(C)c(O)c(Cl)c1)C(F)(F)F ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O[C@@H]1C2(CCN(CC2)C(=O)CCc2cccnc2)c2ccccc2[C@H]1[NH+](C)C ### Response: C[NH+](C)[C@@H]1c2ccccc2C2(CCN(C(=O)CCc3cccnc3)CC2)[C@H]1O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@@H](NC(=O)c1cnc(-c2ccoc2)s1)C(=O)N1CCOCC1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CS(=O)(=O)[C@@H](c1ccccc1)c1ccc(Cl)cc1)N1CCOCC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O[C@H]1CC[NH+](CCCOc2cccc(Cl)c2)Cc2ccccc21 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(/C=N/NC(=O)c2ccccc2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc2ncn(-c3ccc(N)c(N)n3)c2cc1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1nnc([C@H]2CCCO2)o1)C1CCN(S(=O)(=O)c2ccc(Cl)s2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])c1ccccc1 Fragment 2: [5*]N[C@H]([8*])c1ccccc1 ### Response: O=C(N[C@@H](c1ccccc1)C1CC1)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1
functional_group
### Instruction: Does the molecule contain a amide group? COc1cccc(CNC(=O)c2n[nH]c3ccc([N+](=O)[O-])cc23)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc(=O)n2cc(C)ccc2n1 Fragment 2: [14*]c1cccs1 ### Response: CCn1c(SCc2cc(=O)n3cc(C)ccc3n2)nnc1-c1cccs1
functional_group
### Instruction: Does the molecule contain a halide group? C[C@H]1CN(Cc2ccc(Cl)cc2Cl)C[C@H](C)O1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn2c(C)c(C(=O)/C=C/c3ccccc3)nnc2c1-c1ccccc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](CS)COc1cccc2cccnc12 ### Response: 4
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1ccc(NC(=O)[C@H]2CC(=O)N/C(=N\N=C(\C)c3ccccc3)S2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(C)(C)C Fragment 2: [1*]C(=O)N[5*] ### Response: CC(C)(C)NC(=O)N1CC[C@@]2(C1)C(=O)Nc1ccccc12
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(SCC[C@H]2C[NH2+]CCC2)ccnc1 ### Response: c1cc(SCC[C@@H]2CCC[NH2+]C2)ccn1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CN(C(=O)c1cnn(-c2ccccc2)c1)c1ccc(Br)cn1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)CS(=O)(=O)N(c2cc(C(=O)N3CCc4ccccc43)ccc2Cl)C1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? Cc1c(C)c(O)c(C(=O)Cl)c(C)c1O ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCCSc1ccccc1)c1cc(Br)ccc1Cl ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+][C@@H](CCC(F)(F)F)[C@H]1CCOC2(CCC2)C1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]1OC[C@@H](N[5*])[C@@H]1O Fragment 2: [4*]Cc1c[nH]c[nH+]1 ### Response: Cc1ccc(S(=O)(=O)NC[C@H]2OC[C@@H](NCc3c[nH]c[nH+]3)[C@@H]2O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(C)o1 Fragment 2: [12*]S(=O)(=O)c1ccc(C#N)cc1 ### Response: Cc1ccc(C(=O)NC2CCN(S(=O)(=O)c3ccc(C#N)cc3)CC2)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-n2c(SCC(N)=O)nc3c(sc4ccccc43)c2=O)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Clc1ccccc1Cn1ccnc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCSCc1noc([C@H]2CC[C@@H]3CCCC[C@@H]3[NH2+]2)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccncc1 Fragment 2: [16*]c1ccc([16*])cc1 ### Response: C[C@@H](NC(=O)[C@@H]1COc2ccccc21)c1ccc(-c2ccncc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSC[C@H](NCc1cccc(C(N)=O)c1)c1ccccc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CN(C(=O)c2nn(-c3ccc(F)cc3)c3c2CCC3)CCO1 ### Response: 2