task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+][C@@H](C)[C@H]([8*])C Fragment 2: [15*]C1CCCC1 ### Response: COc1ccc([C@H](C)[C@H](C)[NH2+]C[C@H](O)C2CCCC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCc1cc(CNC(=O)N2CCC[C@@H]2c2c(C)n[nH]c2C)ccc1F ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC(=O)Nc1ccc(S(=O)(=O)N2CC[C@@H](C)[C@H](O)C2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@H]2OCCN([C@@H]2CC1)C(c1cc(c(C)o1)S(=O)(N(C)C)=O)=O ### Response: Cc1oc(C(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1S(=O)(=O)N(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [8*]CC[C@@H]([8*])C[NH2+]C ### Response: C[NH2+]C[C@@H](CCc1cccs1)c1ccccc1Br
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](C)c1c(C)noc1C Fragment 2: [5*]Nc1ccc2n[nH]c(=O)n2n1 ### Response: Cc1noc(C)c1[C@@H](C)Nc1ccc2n[nH]c(=O)n2n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(C)c2c(n1)CC(C)(C)CC2=O Fragment 2: [5*]N1CCCC1 ### Response: Cc1nc(N2CCCC2)nc2c1C(=O)CC(C)(C)C2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@H]1Oc2c(c(=O)oc3ccccc23)[C@H]1c1ccc(OC)c(OC)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[S@@](=O)c1ccc(C[NH+]2CCC(OC[C@H]3CCCO3)CC2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccccn1 Fragment 2: [5*]Nc1c[nH]nc1[14*] ### Response: Cc1cccc(C(=O)Nc2c[nH]nc2-c2ccccn2)c1O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@@H]1C[C@@](c2ccccc2)([C@@H](C[NH3+])CO)CCO1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCn1c([C@H](C)NCc2cc3ccccc3[nH]c2=O)nc2ccccc21 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(-c2noc(CNc3ccc(C(=O)N4C[C@H](C)O[C@@H](C)C4)cc3)n2)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCNC1(C#N)CN(C(=O)OC(C)(C)C)C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(C)(C)NC(=O)CCCN1C(=O)[C@@H]2CC[C@](C)(C1=O)C2(C)C ### Response: No
functional_group
### Instruction: Does the molecule contain a aldehyde group? O=C(Cc1cccc2ccccc12)NCCOc1ccc2c(c1)OCO2 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(CS(=O)(=O)N2CCC[C@H](C(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)C2)c1 ### Response: O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)[C@H]1CCCN(S(=O)(=O)Cc2ccccc2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(NC(=O)C(=O)NCc2ccccc2C)c(Cl)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCN(CC(=O)[O-])C(=O)N(CCC)CC1CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc([16*])c1 Fragment 2: [16*]c1ccoc1 ### Response: CCOc1ccc(NC(=O)c2cccc(-c3ccoc3)c2)c(C(N)=O)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1CN(C(=O)c2ccc(C3SCCS3)cc2)CCN1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)NC(=O)N1CCC[C@H](c2nc(-c3cccc(F)c3)no2)C1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1cc(C)c(NC(=O)c2cc(C)no2)cc1OC ### Response: No
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC(C)(C)OC(=O)N1C[C@H](OCc2ccc3ccccc3c2)C[C@H]1C(=O)[O-] ### Response: No
functional_group
### Instruction: Does the molecule contain a carboxyl group? COC(=O)[C@H]1CCCC[C@@H]1NC(=O)c1cc(Cl)c(Cl)n1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCC[NH2+]C1 Fragment 2: [3*]OCC ### Response: CCOCCCC(=O)N[C@H](C)[C@@H]1CCC[NH2+]C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH+](C)CC(C)(C)CN1CCN(c2nc(-c3ccccc3)no2)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])CC1CC[NH+](C[C@@H]2Cc3ccccc32)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1c(C(=O)NCc2ccccc2Cl)sc2nc(-c3cccs3)ccc12 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH2+][C@H](c1occc1C)C)c1cc(-c2n[nH]cn2)ccc1 ### Response: Cc1ccoc1[C@H](C)[NH2+]Cc1cccc(-c2nc[nH]n2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(N)=O Fragment 2: [5*]NCC[8*] ### Response: Cc1cc(C)c(CCNC(=O)COc2ccc(C(N)=O)cc2)c(C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])CC Fragment 2: [4*]Cc1ccnc(/C(N)=N/O)c1 ### Response: CCN(Cc1ccnc(/C(N)=N/O)c1)Cc1ccccn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH+]1CC[C@H](N(C)C(=O)c2cnc(-c3ccsc3)s2)[C@H](C)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@@H]([NH3+])CN(C(=O)/C=C/c2cccs2)C1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(S(=O)(=O)NCCC(=O)Nc2nnc(C(C)(C)C)s2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1c2cc3c(C(C)(C)C)coc3cc2OC(=O)[C@H]1CCC(=O)NCCc1c[nH+]c[nH]1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CO[C@H](C)c1noc([C@@H]([NH3+])CCS(C)(=O)=O)n1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(Nc2ncccc2C(=O)Nc2ccc(Br)cc2)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccn1-c1sc2c(ccc(c2)C([O-])=O)n1 ### Response: O=C([O-])c1ccc2nc(-n3cccc3)sc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(O)cc1 Fragment 2: [9*]n1cc(C)cn1 ### Response: Cc1cnn(CCCCC[NH+]2CCN(c3ccc(O)cc3)CC2)c1
functional_group
### Instruction: Does the molecule contain a phenol group? COCCNC(=O)COc1ccc(-c2nn(C)c(=O)c3ccccc23)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=[N+]([O-])c1ccc(/C=C\C(N(CC[NH+](C)C)c2sc3cccc(c3n2)F)=O)cc1 ### Response: C[NH+](C)CCN(C(=O)/C=C\c1ccc([N+](=O)[O-])cc1)c1nc2c(F)cccc2s1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1[S@@](=O)CCC(=O)NCc1ccc(F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)/C(C#N)=C1/S[C@H](Cc2cccc([N+](=O)[O-])c2)C(=O)N1c1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(C([1*])=O)cc1 Fragment 2: [3*]OC(C)(C)C ### Response: COc1ccccc1N(C)C(=O)c1ccc(C(=O)OC(C)(C)C)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(NC(=O)C(=O)N[C@@H]2CCN(CC(F)(F)F)C2)cc1F ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)C[C@@H]1CCCCCN1C(=O)c1cccnc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCc1cc(C(N)=O)c(NC(=O)c2ccnn2C)s1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(c2c(C[NH+](C)[C@@H](C)C(Nc3c(Cl)cc(cc3)[N+](=O)[O-])=O)cccc2)CCC1 ### Response: C[C@@H](C(=O)Nc1ccc([N+](=O)[O-])cc1Cl)[NH+](C)Cc1ccccc1N1CCCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]N1CCN([5*])CC1 ### Response: C=CCNC(=O)CN1CCN(c2nc(C)nc3sc4c(c23)CCCC4)CC1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1ccc(C(=O)Nc2c(C(=O)Nc3ccc4c(c3)OCO4)oc3ccccc23)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [14*]c1cccc[nH+]1 ### Response: CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Fc1cccc(-c2nc(-c3ccc4c(c3)nnn4C3CCCC3)no2)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C(=C\c1ccccc1)/CSc1nnc(-c2ccncc2)o1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C(=O)NC(=S)NNC(=O)Cn2ccc3ccccc32)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(=O)N2C[C@H]3[C@@H](C2)[C@H]2CCCC[NH+]2C3)ccc2N(C(CC)=O)CCc2c1 ### Response: CCC(=O)N1CCc2cc(C(=O)N3C[C@@H]4C[NH+]5CCCC[C@@H]5[C@@H]4C3)ccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=C\c1ccccc1)/c1c(-c2oc(C)nn2)cccc1 ### Response: Cc1nnc(-c2ccccc2/C=C/c2ccccc2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [4*]C[C@@H]1CCN([5*])C1 ### Response: CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H]1CCN(S(C)(=O)=O)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1cccnc1)N1CCN(C[C@H](O)c2ccccc2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ketone group? CC[C@@H](CSC)N(C)C(=O)N[C@@H]1CCCn2nc(COC)nc21 ### Response: No
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1ccc([C@@H](NC(=O)C(=O)Nc2ccc(Cl)cc2)C(C)C)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(NC(=O)C(=O)N[C@@H](C)c2ccccc2Br)no1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](CCc1ccccc1)NC(=O)NCc1ccccc1F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(C)c(C(=O)N2CC[C@@H]3[C@@H](CCC(=O)N3CCCCO)C2)o1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNS(=O)(=O)[C@@H]1CCN(C(=O)c2cccc(OC3CCCC3)c2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(C2CCCC2)c(=O)c2n(C)c3c(cccc3)c2c(c1)C(N1CCN(CC1)C)=O ### Response: CN1CCN(C(=O)c2cn(C3CCCC3)c(=O)c3c2c2ccccc2n3C)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(N[C@@H](C2CC2)C)ccc(F)cc1I ### Response: C[C@@H](Nc1ccc(F)cc1I)C1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([16*])cc1 Fragment 2: [5*]N[C@H](C)CO ### Response: C[C@H](CO)NC(=O)C(=O)Nc1ccc(-c2cn3ccsc3n2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cccc(N2C[C@H](C(=O)Nc3nc4c(s3)COCC4)CC2=O)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1nn(cc1-c1cc(C(N[C@@H](C)COc2ccc(cc2)Cl)=O)c2c(cccc2)n1)C ### Response: C[C@@H](COc1ccc(Cl)cc1)NC(=O)c1cc(-c2cnn(C)c2)nc2ccccc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[C@@H](CO)C1 Fragment 2: [16*]c1ccccc1 ### Response: Cn1cc(C(=O)N2CC[C@@H](CO)C2)c(-c2ccccc2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cnc([14*])o1 Fragment 2: [1*]C(=O)CC[8*] ### Response: Cc1ccnc(NC(=O)CCc2ncc(-c3ccc(Cl)cc3)o2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc([16*])c(F)c1 Fragment 2: [4*]Cc1cc(Cl)c2c(c1)OCCO2 ### Response: CC(=O)c1ccc(OCc2cc(Cl)c3c(c2)OCCO3)cc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [15*][C@H]1CCOC1 ### Response: CCOc1ccc(F)c(C(=O)Nc2ccccc2O[C@H]2CCOC2)c1F
canonicalization
### Instruction: Canonicalize the following SMILES string. c12sc(c(C)c1ccc(n2)C(F)(F)F)C(N(C1CCCC1)C1CC1)=O ### Response: Cc1c(C(=O)N(C2CCCC2)C2CC2)sc2nc(C(F)(F)F)ccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCn1nnnc1CN(C)[C@H](C)c1cccc(S(N)(=O)=O)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)C[C@@H]1CCCN1C(=O)c1ccc2c(c1)COC2 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CCOc1ccc(Cl)cc1)C ### Response: CCCCOc1ccc(Cl)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1cccc(C)c1C Fragment 2: [16*]c1cccc(C)c1C ### Response: Cc1cccc(OC[C@@H](O)CN2CC[NH+](C)CC2)c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1c[nH]c2nccc(Cl)c12 Fragment 2: [5*]N1CCCC[C@@H]1C1OCCO1 ### Response: O=S(=O)(c1c[nH]c2nccc(Cl)c12)N1CCCC[C@@H]1C1OCCO1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(ccc1)Cl)[C@@H](NC(CN(S(=O)(c1ccc2c(c1)OCCO2)=O)C)=O)C ### Response: C[C@H](NC(=O)CN(C)S(=O)(=O)c1ccc2c(c1)OCCO2)c1ccccc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. O(Cc1nc2scc(n2c(c1)=O)C)C(C(c1ccccc1)c1ccccc1)=O ### Response: Cc1csc2nc(COC(=O)C(c3ccccc3)c3ccccc3)cc(=O)n12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(CC(N)=S)cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(CC)N(CCOC)C(=O)[C@H]1CC[NH2+][C@@H]1C ### Response: 5
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1cc(C(=O)NC[C@](C)(O)CN2CCOCC2)c2ccccc2n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CCC(CC1)C(OCC)=O)c1cccnc1[S-] ### Response: CCOC(=O)C1CCN(C(=O)c2cccnc2[S-])CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CN([5*])C Fragment 2: [1*]C(=O)c1ccc(F)cc1 ### Response: COC(=O)c1ccccc1NC(=O)CN(C)C(=O)c1ccc(F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1=C[C@@H]([C@@H]2NN=C3SC(c4ccccc4)=NN32)N=N1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(c2CC[NH+](C)Cc2s1)CNC(NCC(C)C)=O)-n1cccc1 ### Response: CC(C)CNC(=O)NCc1c(-n2cccc2)sc2c1CC[NH+](C)C2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(C)(C)O ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1cccc(C(F)(F)F)c1=O)N1CCC[C@@H]2CCCC[C@@H]21 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc2ccccc2c1 Fragment 2: [4*]Cc1ccncc1 ### Response: c1ccc2cc(NCc3ccncc3)ccc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1[NH+]=C(c2cccc(OC)c2)NC1=S Fragment 2: [16*]c1ccccc1 ### Response: COc1cccc(C2=[NH+][C@@H](c3ccccc3)C(=S)N2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(C=O)cc1OC Fragment 2: [4*]CCC ### Response: CCCOc1ccc(C=O)cc1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(CC)ns1 Fragment 2: [3*]Oc1ccc(C=O)cc1Cl ### Response: CCc1nsc(Oc2ccc(C=O)cc2Cl)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [1*]C(=O)c1cccc(OC)c1 ### Response: COc1cccc(C(=O)Nc2c(C(=O)N3CCN(c4ccccc4OC)CC3)oc3ccccc23)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@H](NC(=O)C[NH+]1CCN(CC(=O)N2CCCCC2)CC1)c1ccccc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@H](C)c1ccc(OC(F)F)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amine group? Cc1cc(NC(=O)c2csc(Nc3cccnc3)n2)no1 ### Response: Yes