task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. O1c2cc(ccc2OC1)CC[C@@H]([NH2+][C@H]1C(N(CC1)c1cn(C)nc1)=O)C ### Response: C[C@@H](CCc1ccc2c(c1)OCO2)[NH2+][C@@H]1CCN(c2cnn(C)c2)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc2nc(/N=N/NC#N)sc2c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? CCc1cc(NC2CC[NH+](C[C@@H]3CCCO3)CC2)n2nc(C)c(C)c2n1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(O[C@@H](C)c2ccccc2)ccc1NC(=O)N1CC[C@@H](C)[C@@H](O)C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccccc1Br)C(=O)N[C@H]1C[C@H]1C1CCCCC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOCC[NH2+][C@H]1CCO[C@]2(CCSC2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. o1c(Cn2cccc(c2=O)C)nc(-c2ccc(cc2)S(C)(=O)=O)n1 ### Response: Cc1cccn(Cc2nc(-c3ccc(S(C)(=O)=O)cc3)no2)c1=O
functional_group
### Instruction: Does the molecule contain a nitro group? CCN1CCN(C(=O)[C@H]2CCCN(C(=O)c3csc(Nc4cccc(C)c4)n3)C2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CN1C(=O)[C@]2(C(C(=O)OC)=C(N)Oc3[nH]nc(C)c32)c2ccccc21 Fragment 2: [16*]c1cccc(F)c1 ### Response: COC(=O)C1=C(N)Oc2[nH]nc(C)c2[C@@]12C(=O)N(Cc1cccc(F)c1)c1ccccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH2+][C@@H](Cc1ccc(F)cc1)c1ccc(Cl)cn1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H](c1nc([C@H]2CSCCO2)no1)N1CC[NH2+]CC1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(/C=c2\s/c(=C(/C#N)c3nnc4n3CCCCC4)n(-c3ccccc3)c2=O)cc1OC ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C1CCCC(Nc2cccc(C(F)(F)F)c2)=C1Cl ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)[C@@]2(C(=O)N(CCC#N)Cc3ccccc3)CC[C@]1(C)C(=O)O2 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1coc(C(=O)N(c2cccc(c2)C#C)CC(NC)=O)c1 ### Response: C#Cc1cccc(N(CC(=O)NC)C(=O)c2ccco2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc2c(s1)COCC2 Fragment 2: [1*]C(=O)c1c[nH]c2ccc([N+](=O)[O-])cc12 ### Response: O=C(Nc1nc2c(s1)COCC2)c1c[nH]c2ccc([N+](=O)[O-])cc12
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2nn[nH]c2ccc1C(N[C@H]1Sc2ccccc2N1)=O ### Response: O=C(N[C@@H]1Nc2ccccc2S1)c1ccc2[nH]nnc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(OCO2)ccc1OCCNC(c1cc(on1)C1CC1)=O ### Response: O=C(NCCOc1ccc2c(c1)OCO2)c1cc(C2CC2)on1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCC2(CCC(=O)N([10*])C2)CC1 Fragment 2: [4*]Cc1ccc(OC)c(C)c1C ### Response: COc1ccc(C[NH+]2CCC3(CCC(=O)N(C[C@@H]4CCCO4)C3)CC2)c(C)c1C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CCC1CC)CNc1nc(ns1)COC ### Response: CCC1CCC(CNc2nc(COC)ns2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. CCc1nn(cc1C(N1C[C@@H](C)O[C@H](C)C1)=O)C ### Response: CCc1nn(C)cc1C(=O)N1C[C@@H](C)O[C@H](C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c([C@H](C#N)NC(c2ccc(CSC)cc2)=O)c(C)ccc1 ### Response: CSCc1ccc(C(=O)N[C@@H](C#N)c2ccccc2C)cc1
functional_group
### Instruction: Does the molecule contain a thiol group? Cn1cc([C@@H]2C[C@H]2C(=O)NNc2ccccc2C(F)(F)F)cn1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? Cn1cc(C#N)c(NC(=O)C[NH+](Cc2ccccc2)Cc2ccccc2)n1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc2c(s1)[C@@H](NC[C@@H](O)c1cccc(OC(F)F)c1)CCC2 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCn1nnnc1[14*] Fragment 2: [4*]CCn1nnnc1S[11*] ### Response: CC[NH2+]CCn1nnnc1S[C@H]1CCO[C@@]2(CCSC2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=S1(=O)N[C@@H](C2CC[NH+](Cc3c[nH]c4ccccc34)CC2)Nc2ccccc21 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc2cnn([9*])c2nc1Cl Fragment 2: [5*][NH+]1CCC([15*])CC1 ### Response: CC(C)COC1CC[NH+](Cc2cc3cnn(C(C)C)c3nc2Cl)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ncc(C(=O)N2CCC(c3cc4n(n3)[C@@H](C(F)(F)F)C[C@@H](C)N4)CC2)cn1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? N#Cc1nc(-c2ccco2)oc1N1CCN(C(=O)CSc2ccc(F)c(F)c2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nnc(C)n1/N=C/c1ccc(OCc2ccccc2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](CC#N)N(C)C(=O)CN1CCCOC1=O ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCN/C(NC[C@](C)(O)c1cnn(C)c1)=[NH+]/CC ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? COc1ccc(C)cc1C[NH+]1CCC[C@H]([C@@H]2C[C@H](C(F)(F)F)n3ncnc3N2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? CC(C)[C@@H](CO)NC(=O)c1cccc(C(F)(F)F)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a carboxyl group? CC(C)[C@@H](CO)NC(=O)NC1CCN(C(=O)c2ccco2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccc1F Fragment 2: [16*]c1ccccc1F ### Response: O=C(Nc1ccccc1F)N1CCN(CCOc2ccccc2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)COc1ccc(N[C@@H]2CS[C@H](C)C2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(CSc1nnc(NC(=O)C2CCC2)s1)c1ccc(F)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(N)=O Fragment 2: [5*][NH2+][C@@H]1CCC[C@H](C)C1 ### Response: C[C@H]1CCC[C@@H]([NH2+]Cc2cc(C(N)=O)ccc2F)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C(=O)[C@@H]1CC(=O)N(C)[C@@H]1c1cccnc1)[C@@H]1CCc2ccccc2C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)N[C@@H](C)c1ccccc1C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCn1c(=O)n(CCC(=O)N2CCN(S(=O)(=O)N3C[C@H](C)O[C@@H](C)C3)CC2)c2ccccc21 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNC(=O)N[C@@H]1CN(Cc2ccncc2Cl)C[C@@H]1OC ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(CC)S(=O)(=O)c1ccc2c(c1)CCCN2C(=O)c1ccc(Cl)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? Cc1cccc(-c2cnc(Br)nc2)c1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCC1CCCC1)N1CCC(COc2ccccc2C(=O)N2CCCC2)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(/N=C(\[O-])CCCOc1ccc(F)cc1F)c1ccc(F)cc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cc(C)cn1 Fragment 2: [5*]NC[C@H]1CCC[C@@H]1O ### Response: Cc1cnn(CCCNC(=O)NC[C@H]2CCC[C@@H]2O)c1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(Nc1ccnn1Cc1ccccn1)N[C@H]1C[C@H]1c1cccc(Cl)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1Cl Fragment 2: [1*]C(=O)C[8*] ### Response: O=C(Cc1ccccc1Cl)N1CCc2c(F)ccc(F)c2C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [1*]C(=O)c1cc(C)n([9*])c1C ### Response: Cc1cc(C(=O)N2CCn3c(C)nnc3C2)c(C)n1Cc1ccco1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#CCC[NH+]1CCC([C@@H](O)c2ccc(Cl)cc2)CC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(c2ccc(NC(=O)c3c(ccc([N+]([O-])=O)c3)N3CCOCC3)cc2)CCN(CC1)C(=O)CC(C)C ### Response: CC(C)CC(=O)N1CCN(c2ccc(NC(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)cc2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)[C@H](C)[C@@H]([8*])C Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: C[C@H](c1ccc(Cl)cc1)[C@@H](C)N(C)C(=O)[C@@H]1CCC(=O)O1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccccc1C(=O)NC[C@@H](c1ccc(N(C)C)cc1)N1CCc2ccccc2C1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C)c(-c2csc(NC(=O)[C@H]3CCCN3S(=O)(=O)c3cccs3)n2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccc(C(=O)OCCCl)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? O=C(c1ccc(Cl)cc1)N1CCC(Cn2cnc3ccccc32)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)[C@@H]1CN(Cc2cc(F)cc(Br)c2)CC[NH2+]1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a amide group? CCc1n[nH]c(=S)n1CCNC(=O)c1cc(C)nc2c1c(=O)[nH]n2C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. o1c(ncc1-c1ccccc1)COC(c1oc(S(N)(=O)=O)cc1)=O ### Response: NS(=O)(=O)c1ccc(C(=O)OCc2ncc(-c3ccccc3)o2)o1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1nn(C)c(OC)c1C[NH+]1CCC[C@@H](Cc2noc(C)n2)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN1C[C@H](NC(=O)/C=C/c2cnc(C(C)(C)C)s2)CCC1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(cc(c(c1)I)C)NC(c1cc([N+]([O-])=O)c(cc1)OC)=O ### Response: COc1ccc(C(=O)Nc2cc(C)c(I)cc2C)cc1[N+](=O)[O-]
functional_group
### Instruction: Does the molecule contain a amide group? CC[C@H](C)N1C(=O)C2(CCCC2)NC(=O)[C@]1(C)CC ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CS(=O)(=O)c1ccc([16*])cc1 Fragment 2: [8*]C(C)(C)C ### Response: CC(C)(C)c1ccc(S(=O)(=O)CC(=O)Nc2ccc(Br)cc2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12S(=O)(=O)C(=CN(c3cc(ccc3)C(OCC)=O)c1cc(cc2)F)C(=O)c1ccc(OC)cc1 ### Response: CCOC(=O)c1cccc(N2C=C(C(=O)c3ccc(OC)cc3)S(=O)(=O)c3ccc(F)cc32)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CS(=O)(=O)N[C@H]1c2cccc3cccc(c23)[C@H]1Nc1ccc(Br)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[S@@](=O)c1ccccc1 Fragment 2: [4*][C@H](CO)C(C)C ### Response: CC(C)[C@@H](CO)NC(=O)Nc1cccc(C[S@@](=O)c2ccccc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(C(=O)[C@@H]1COc2ccc(F)cc2C1)[C@H](C)CS(C)(=O)=O ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1ncccc1N[C@H]1CC[NH+](C2CC2)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccnc1[C@@H](NC(=O)NC[C@@H](C)CCO)C(C)C ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [9*]n1nnnc1[14*] ### Response: Cc1cccc(N2CC[NH+]([C@@H](CC(C)C)c3nnnn3C(C)(C)C)CC2)c1C
functional_group
### Instruction: Does the molecule contain a ether group? CCSc1ccc([C@H](C)NC(=O)N[C@@H]2CCC[C@@]2(C)CO)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCSc1c[nH]c2ccccc12)c1cnn2c1OCCC2 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cccc(N[5*])c1 Fragment 2: [14*]c1nc2ccc(C)cc2s1 ### Response: CC(=O)Nc1cccc(Nc2nc3ccc(C)cc3s2)c1
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)N[C@@H](C(=O)NCCc1nc(C(C)C)no1)C1CCCC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? C[C@H]1CCC[C@H](C)N1C(=O)N1CCC[C@H]([NH+](C)C)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nccc(OC)n1 Fragment 2: [5*]N1CCCC1 ### Response: COc1ccnc(N2CCC(C(=O)N3CCCC3)CC2)n1
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1ccccc1NC(=O)c1cc2c([nH]c1=O)C[C@@H](c1ccccc1)CC2=O ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(-c2[nH]c(c(C#N)cc2)=O)cc(Cl)c1Cl ### Response: N#Cc1ccc(-c2ccc(Cl)c(Cl)c2)[nH]c1=O
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCCOc1cc(=O)c(C(=O)N2CCCC2)nn1-c1ccc(C)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@@H](C[C@@H]1C)NS(=O)(c1c(c(ccc1)N)C)=O ### Response: Cc1c(N)cccc1S(=O)(=O)N[C@H]1CCC[C@@H](C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1CCN([10*])C1=O Fragment 2: [16*]c1ccccc1Cl ### Response: O=C(Cc1cccc(F)c1F)N[C@H]1CCN(c2ccccc2Cl)C1=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(c1cccc2c1NCCC2)N1C[C@H](CO)C[C@H](C[NH+]2CCCC2)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N[C@@H]1CCCc2ccc(F)cc21 Fragment 2: [5*]N1CCOC[C@@H]1C ### Response: C[C@H]1COCCN1C(=O)N[C@@H]1CCCc2ccc(F)cc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [5*]N[C@H]1CC(=O)N([10*])C1 ### Response: CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)N(C2CC2)C1)N1CCCCC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@]1([15*])CCC[C@H]1C Fragment 2: [5*][NH2+]CC ### Response: CC[NH2+]C[C@@]1(c2ccc(C)c(C)c2)CCC[C@H]1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C)c1nc2ccc(NC(=O)c3cccc(OCC(N)=O)c3)cc2o1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1csc(-c2cccc(CN/C([O-])=N/S(=O)(=O)c3ccccc3)c2)n1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1cc([N+](=O)[O-])c(C[NH+](Cc2cscc2)C)cc1)N ### Response: C[NH+](Cc1ccsc1)Cc1ccc(C(N)=O)cc1[N+](=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nnc(N(CCC(C)C)C(=O)Cc2ccon2)c2ccccc12 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](C(=O)NCc1ccco1)[NH+]1CCCC[C@@H]1C(=O)[O-] ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1c(Br)cc(Cl)cc1S(=O)(=O)[N-]c1cc(F)ccc1F ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitro group? O=C(c1cccc(/N=C2/N[C@H]3CS(=O)(=O)C[C@H]3S2)c1)N1CC[NH+](C2CCCCC2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@@H](Sc1ncn[nH]1)C(=O)N1CC(=O)Nc2cc(C(F)(F)F)ccc21 ### Response: No