task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a amine group? Cc1cnc(C(C)(C)NC(=O)C2=NN(C)C(=O)CC2)s1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc(=O)[nH]n1 Fragment 2: [4*]Cc1ccc(C)cc1 ### Response: Cc1ccc(CNS(=O)(=O)c2cc(-c3ccc(=O)[nH]n3)ccc2C)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccccc1CNC(=O)C[C@@H](NC(N)=O)c1cccs1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [14*]c1nc2ccccc2o1 ### Response: CCOC(=O)N1CCC(NC(=O)[C@H]2CCCN(c3nc4ccccc4o3)C2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C2CC3CC(C2)(/N=C/c2ccc(cc2)N(C)C)CC1C3 ### Response: CN(C)c1ccc(/C=N/C23CC4CC(CC(C4)C2)C3)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCNC(=O)C[NH2+]Cc1cc(C#N)cs1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [10*]N1N=C(C(=O)N=c2[nH]c3ccccc3[nH]2)N[C@@H](C)C1=O ### Response: C[C@@H]1NC(C(=O)N=c2[nH]c3ccccc3[nH]2)=NN(c2ccccc2)C1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](NC(=O)N1CCCCCCC1)[C@@H]1CCCO1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C)C(=O)CNc1cc(F)ccc1OC[C@H]1CCCO1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(=O)n2cc(-c3ccc(Cl)cc3)nc2[nH]1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1C[C@@H]1c1ccc(CN(C)S(=O)(=O)N2CCCCCC2)o1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? C[C@H]1OCC[C@H]1C(=O)N(C)[C@@H](C)CS(C)(=O)=O ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CC1(O)CCCCC1)Nc1ccccc1OCc1cscn1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-][n+]1c2ccccc2[n+]([O-])c(c1C)C(OCCO)=O ### Response: Cc1c(C(=O)OCCO)[n+]([O-])c2ccccc2[n+]1[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCCC[C@H]1[NH+]1CCC(NCC/N=C(\O)c2ncccc2O)CC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)C1CCN(C(=O)C[NH+]2CCC[C@@H]2c2ccc3c(c2)OCCO3)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)n1nccc1NC(=O)[C@@H](C)Sc1nnc(CO)n1C1CC1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1n[nH]c([O-])c1[C@H](c1c(C)[nH][nH]c1=O)[C@H]1CN(Cc2ccccc2)c2ccccc21 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1sccc1C Fragment 2: [1*]C(=O)CCCC[NH3+] ### Response: Cc1ccsc1CNC(=O)CCCC[NH3+]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)c(OC)c1 Fragment 2: [16*]c1ccccc1Cl ### Response: COc1ccc(-c2nnc3sc(-c4ccccc4Cl)nn23)cc1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](C)c1sc([14*])nc1C Fragment 2: [8*]CCOC ### Response: COCCc1nc(C)c([C@@H](C)N[C@@H]2CCOc3ccccc32)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [4*]CC(=O)N1N=C(c2ccc(C)cc2)C[C@@H]1[13*] ### Response: Cc1ccc(C2=NN(C(=O)CSc3nncs3)[C@@H](c3ccco3)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 ### Response: 5
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(C(N(C)Cc2cc3C[C@H](C)Oc3cc2)=O)cc(-c2cn(nc2)CC)o1 ### Response: CCn1cc(-c2cc(C(=O)N(C)Cc3ccc4c(c3)C[C@H](C)O4)no2)cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. Brc1cnc2c(c1)[nH+]c(n2Cc1nc(sc1)C)N ### Response: Cc1nc(Cn2c(N)[nH+]c3cc(Br)cnc32)cs1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(CCO[C@@H]1[C@@H](CCCC1)NC(=O)Cc1n[nH]c(C)c1)C ### Response: Cc1cc(CC(=O)N[C@@H]2CCCC[C@@H]2OCCC(C)C)n[nH]1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1noc([C@H]2CCC[NH+]([C@@H](C)CC#N)C2)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCOC(=O)CN(C)Cc1cc(=O)oc2cc(C)c(Cl)cc12 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? CS(=O)(=O)NCCNC(=O)c1ccccc1I ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1ccco1)[C@@H]1CCCN(C(=O)c2cccn2-c2cccnc2)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(C)c(Cl)c(C)c1 Fragment 2: [5*]Nc1ccc([16*])cc1 ### Response: CC(=O)c1ccc(NC(=O)CCCOc2cc(C)c(Cl)c(C)c2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [15*]C1([15*])CCOCC1 ### Response: COc1ccccc1C1(c2nnc(-c3ccc(F)cc3)o2)CCOCC1
functional_group
### Instruction: Does the molecule contain a amine group? CCN(Cc1ccccc1C)S(=O)(=O)c1cccc(S(=O)(=O)NC)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)(C)(CCCOc1ccc(F)cc1)C([O-])=O ### Response: CC(C)(CCCOc1ccc(F)cc1)C(=O)[O-]
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1-c1nn(CN2CCc3sccc3C2)c(=S)n1C ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)CN(C/C(N)=N/OCC(=O)NC2CC2)CCO1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH2+][C@H](c1cccc(OC(F)(F)F)c1)c1cscc1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(N2CCN(c3nccn4c(=O)n(CC(=O)NC5CCCCC5)nc34)CC2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OCC=C)ccc(cc1)/C=N/NC(=O)C(Nc1c(C)c(Cl)ccc1)=O ### Response: C=CCOc1ccc(/C=N/NC(=O)C(=O)Nc2cccc(Cl)c2C)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccoc1C Fragment 2: [16*]c1ccc(C)c(C)c1 ### Response: Cc1ccc(-c2nc(NC(=O)c3ccoc3C)sc2C)cc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1cc(C(=O)Nc2cc(F)ccc2F)n(C)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(cc(o2)C(=O)NCC(Nc2ccon2)=O)ccc1 ### Response: O=C(CNC(=O)c1cc2ccccc2o1)Nc1ccon1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH2+]CCOc1c(C)cc(C)cc1Br ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [5*]N1c2ccc(C)cc2[C@H]2C[NH+](C)CC[C@@H]21 ### Response: Cc1ccc2c(c1)[C@H]1C[NH+](C)CC[C@@H]1N2C(=O)[C@@H]1C[C@@H]1c1ccc(F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H](C)(Oc1cc(c(F)cc1)F)C(NCC(=O)N[C@@H]1CS(=O)(CC1)=O)=O ### Response: C[C@@H](Oc1ccc(F)c(F)c1)C(=O)NCC(=O)N[C@H]1CCS(=O)(=O)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[NH+]2CCC[C@@H]2C1 Fragment 2: [14*]c1cc(C)nc(N)n1 ### Response: Cc1cc(N2CC[NH+]3CCC[C@@H]3C2)nc(N)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [12*]S(=O)(=O)c1ccc([16*])cc1 ### Response: Cc1ccc(NS(=O)(=O)c2ccc(CCC(=O)N3CCCCCC3)cc2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccsc1-c1cccc(NC(NC[C@@H]2COCC2)=O)c1 ### Response: O=C(NC[C@H]1CCOC1)Nc1cccc(-c2cccs2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(/C=C/c1occc1)[NH+](C1CCC1)CCC(F)(F)F ### Response: FC(F)(F)CC[NH+](C/C=C/c1ccco1)C1CCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1cc(ccc1[C@@H]1N(N=C2[C@@H]1N1CCC2CC1)C(=O)C)Cl ### Response: CC(=O)N1N=C2C3CCN(CC3)[C@@H]2[C@@H]1c1ccc(Cl)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CCCCC1)c1ccccc1NC(=O)C(=O)NCCc1onc(C)n1 ### Response: Cc1noc(CCNC(=O)C(=O)Nc2ccccc2N2CCCCC2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cccc1)C(C)([C@@H](C)NC(=O)N(Cc1nccs1)C)C ### Response: C[C@@H](NC(=O)N(C)Cc1nccs1)C(C)(C)c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N[C@H](CCO)C1CC1)c1nc(C2CC2)n2ccccc12 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CO[C@H]1CCCN(C(=O)NC2CCC(Oc3ccc(C#N)cn3)CC2)C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)c1ccc([C@@H]2CCCN2C(=O)[C@@H](C)C2CC2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=[S@](Cc1cc(-c2ccccc2)on1)Cc1ccc(F)cc1Cl ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccnc(Oc2cccc(CO)c2)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc2cc([N+](=O)[O-])ccc2s1 Fragment 2: [5*]Nc1ccc2c(c1)OCCO2 ### Response: O=C(Nc1ccc2c(c1)OCCO2)c1cc2cc([N+](=O)[O-])ccc2s1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1n(nc(c1-c1cc(nc(n1)NC1CCCCCC1)C(F)(F)F)C)C ### Response: Cc1nn(C)cc1-c1cc(C(F)(F)F)nc(NC2CCCCCC2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? c1ccc(C[C@H]([NH2+]CCc2nc[nH]n2)C2CCCCC2)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(F)cc1/C([O-])=N/S(=O)(=O)c1ccc2c(c1)OCCO2 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Fc1cc(F)c(N[C@H]2CCC[C@@H]2[C@@H]2CCCC[NH2+]2)cc1F ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@H](NC(=O)CN(C)S(=O)(=O)c1ccc2c(c1)OCCO2)c1ccccc1Cl ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? [NH3+][C@@H]1c2ccccc2C2(CCN(C(=O)Cc3ccc(O)c(Cl)c3)CC2)[C@H]1O ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n12c(c(C(Nc3c(ccc(Cl)c3)Sc3n(cnn3)C)=O)cnc2SCC1)=O ### Response: Cn1cnnc1Sc1ccc(Cl)cc1NC(=O)c1cnc2n(c1=O)CCS2
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)c1ccccc1NC(=O)C(=O)Cc1nc2ccccc2s1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(c(C(NCc2cnccc2)=O)c1)N1CCC(CC1)C)[N+](=O)[O-] ### Response: CC1CCN(c2ccc([N+](=O)[O-])cc2C(=O)NCc2cccnc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2cc(C[NH2+]CCCN3CCOCC3)c(=O)[nH]c2c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)c(cc(c1)-n1cc(c(n1)C(OCC)=O)C=O)C ### Response: CCOC(=O)c1nn(-c2ccc(C)c(C)c2)cc1C=O
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H](C1CCOCC1)([NH2+][C@H]1c2c(CCC1)n(C)nc2)c1ccc(cc1)OC ### Response: COc1ccc([C@H]([NH2+][C@@H]2CCCc3c2cnn3C)C2CCOCC2)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cc(C(=O)Cn2c(C(F)(F)F)nc3ccccc32)c(C)n1-c1nccs1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])c1cccn1C[C@@H]1CN2CCC[C@@H]2CO1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCC[C@H]1[13*] Fragment 2: [15*][C@@H]1CCCC[C@@H]1O ### Response: CC(C)COC(=O)N1CCCC[C@H]1[C@@H]1CCCC[C@@H]1O
functional_group
### Instruction: Does the molecule contain a nitro group? N#Cc1ccc(/C=C/C(=O)N2C[C@@H](O)C[C@H]2C(=O)[O-])cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[NH+]([C@@H]2[C@H](C1)CCC2)CCCc1cn(nc1)C ### Response: Cn1cc(CCC[NH+]2CCC[C@@H]3CCC[C@@H]32)cn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)NS(=O)(=O)c1cc(C(=O)[O-])cc(-c2ccc(CO)cc2)c1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1CCCN(C(=O)Nc2ccc3ccccc3c2)[C@H]1CO ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](CN[5*])CC(C)C Fragment 2: [5*][NH+](C)C ### Response: CC(C)C[C@H](CNC(=O)c1ccn(-c2ccccc2)n1)[NH+](C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#Cc1ccc(Cn2cnc(NC(=O)NCC3CC3)n2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1([C@H](CC)[NH2+]CCn2c(nnc2)C2CC2)c(Cl)cccc1F ### Response: CC[C@H]([NH2+]CCn1cnnc1C1CC1)c1c(F)cccc1Cl
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(CC(=O)NCc2ccc(NC(=O)c3ccncc3)cc2)no1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(CCc2nc3nccc(-c4cccnc4)n3n2)cc1OC ### Response: 1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1ccc([C@@H](C)NC(=O)CCS(=O)(=O)c2ccc(Cl)cc2)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C#CCn1/c(=N/S(=O)(=O)c2ccc(F)cc2)sc2cccc(F)c21 ### Response: 2
functional_group
### Instruction: Does the molecule contain a phenol group? COc1ccc(Br)cc1CNc1ccc(-n2cncn2)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(C[NH+]2CC[C@]3(O)CCCC[C@@H]3C2)cc1O ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)NCc1ccc(C(=O)NCC2(c3cccs3)CCCC2)o1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C)c(S(=O)(=O)N2CCC(C(=O)Nc3ccccc3Cl)CC2)c(C)c1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC1CC[NH+]([C@@H](C)CNC(=O)Cc2ccccc2Cl)CC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCc1ccc(C(=O)NC(C)(C)c2ncc(C)s2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? CC(C)CC1([C@@H]([NH3+])Cc2nc3ccccc3o2)CCCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1C[C@](O)([C@@]2(C[NH3+])CC[C@H](CC)C2)CCO1 Fragment 2: [8*]C(C)C ### Response: CC[C@H]1CC[C@](C[NH3+])([C@]2(O)CCO[C@H](C(C)C)C2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [5*]N1CCN([5*])CC1 ### Response: CN1N=C(C(=O)N2CCC[C@H](CCC(=O)N3CCN(c4cccc[nH+]4)CC3)C2)CCC1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(=O)N2CCc3c([nH]c4c3cccc4)C2)c(=O)[nH]cc(c1)[N+](=O)[O-] ### Response: O=C(c1cc([N+](=O)[O-])c[nH]c1=O)N1CCc2c([nH]c3ccccc23)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc(=O)oc2cc(O[3*])ccc12 Fragment 2: [3*]OC(C)C ### Response: COc1cc(Cl)c(O)cc1NC(=O)c1cc(=O)oc2cc(OC(C)C)ccc12
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](C(=O)C1=c2ccccc2=[NH+]C1)[NH+]1CCC[C@@H]1[C@@H]1CC=CS1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(C)c1CCCNC(=O)NCCC1CCCCC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCCN1C(=O)CNc1cc(C(=O)NC[C@H]2CCCO2)ccc1 ### Response: O=C(NC[C@H]1CCCO1)c1cccc(NCC(=O)N2CCCCC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)c1cc(NC(=O)Cn2ccccc2=O)no1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(ccc1)NC(C1(c2cc(-c3cc4c(cc3)OCO4)on2)CC1)=O)C(F)(F)F ### Response: O=C(Nc1ccccc1C(F)(F)F)C1(c2cc(-c3ccc4c(c3)OCO4)on2)CC1