task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a amide group? CCCn1nc(C(=O)Nc2cncc3ccccc23)ccc1=O ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[C@@H]1OCC[C@H]1CNC(=O)N1C[C@H]2CCCC[C@H]2C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1SCCC[C@H]1N[C@@H]1CC[NH+]2CCCC[C@H]12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nccs1 Fragment 2: [4*]Cc1ccc(C[4*])o1 ### Response: FC(F)SCc1ccc(CN2CCC[C@@H](c3nccs3)C2)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COc1ccccc1-c1ccccc1)O[C@@H]1CCS(=O)(=O)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[C@](C)(O)C[NH2+][C@H]1CCOC2(CCCC2)C1 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]CC[8*] Fragment 2: [5*][NH2+][C@H](C)C[8*] ### Response: CCc1nncn1CC[NH2+][C@H](C)Cn1c[nH+]c(C)c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2[10*] ### Response: CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCNC(=O)NC[C@@H]1CCC[NH+](C)[C@@H]1c1cccs1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1ccc(C[NH2+]CC2(CC2)c2ccccc2)cc1)C(=O)C ### Response: CC(=O)Nc1ccc(C[NH2+]CC2(c3ccccc3)CC2)cc1
functional_group
### Instruction: Does the molecule contain a nitrile group? N#Cc1ccc(NC(=O)C(=O)NCc2cn3ccsc3n2)cc1Cl ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1ccc([C@H](C)N(C)C(=O)NCC2CC2)cc1 ### Response: C[C@@H](c1ccc(F)cc1)N(C)C(=O)NCC1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1CC(=O)N([10*])C1 Fragment 2: [15*]C1CCCCCC1 ### Response: Cc1cc(=O)c(C(=O)N[C@H]2CC(=O)N(C3CCCCCC3)C2)c(C)[nH]1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc2oc([C@@H](C)NC(=O)NCc3ncoc3C)c(C)c2c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. o1nc(nc1[C@@H](C(C)C)NC([C@@H](c1cscc1)C)=O)-c1ccncc1 ### Response: CC(C)[C@@H](NC(=O)[C@H](C)c1ccsc1)c1nc(-c2ccncc2)no1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)c1sc2nc([14*])c3c(c2c1N)CC(C)(C)OC3 ### Response: CCOC(=O)c1sc2nc(C(C)C)c3c(c2c1N)CC(C)(C)OC3
functional_group
### Instruction: Does the molecule contain a carboxyl group? COC(=O)[C@@H](C)SCc1nc2scc(-c3ccccc3)c2c(=O)[nH]1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@]2(OCC[C@H](C2)[NH2+][C@@H](C(CC)CC)C)CO1 ### Response: CCC(CC)[C@@H](C)[NH2+][C@@H]1CCO[C@]2(CCOC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. [S@]1(=O)C(C)(C)CN(CC1)CC(=O)c1cc(C)n(c1C)CC ### Response: CCn1c(C)cc(C(=O)CN2CC[S@](=O)C(C)(C)C2)c1C
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N[C@@H](C)CC)CCNC(NCc1cccc(C)n1)=O ### Response: CC[C@H](C)NC(=O)CCNC(=O)NCc1cccc(C)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(NC(=O)N2CCCN(c3nccs3)CC2)no1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nnc([14*])o1 Fragment 2: [5*]NC[C@H]1CCCC[NH+]1[5*] ### Response: Cc1ccc(-c2nnc(C[NH+]3CCCC[C@@H]3CNC(=O)OC(C)(C)C)o2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CCC[NH+](Cc2csc(NC(=O)c3cn(Cc4ccccc4)nn3)n2)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O[C@H](CSc1nnc(-c2c[nH]c3ccccc23)n1C1CC1)CN1CCOCC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCc1ccc(NC(=O)[C@H](C)[NH+]2CCC(O)(C(F)(F)F)CC2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1cc(C)c2c(c1)NC(=O)[C@@]2(O)CC(=O)c1cccs1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? Cc1nc(C)c([C@@H](C)[NH2+][C@H]2CC(C)(C)OC2(C)C)s1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c12n(c(=O)cc([nH+]1)CN(Cc1occc1)c1ccc(C)cc1)cccc2 ### Response: Cc1ccc(N(Cc2cc(=O)n3ccccc3[nH+]2)Cc2ccco2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](Nc1cc(F)cc(F)c1)c1cc(F)ccc1O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1([15*])CCCC1 Fragment 2: [6*]C(=O)[C@H]([8*])C#N ### Response: Cc1csc([C@H](C#N)C(=O)C2(Cc3cccc(Cl)c3)CCCC2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1OCC[C@H]1C(=O)Nc1ccccc1C#CCCO ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)CCC1N=C2C(C(=O)N=1)=C1CCCC[C@@H]1S2 ### Response: CCCCC1=NC(=O)C2=C3CCCC[C@@H]3SC2=N1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(C)c(NC(C2C[C@H](C)O[C@H](C2)C)=O)c1)OCCOC ### Response: COCCOc1ccc(NC(=O)C2C[C@H](C)O[C@@H](C)C2)c(C)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H](SC1CCCCC1)C(=O)NC(=O)NC1CCCC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O(CCOC(C)C)C(=O)C=C1CCSCC1 ### Response: CC(C)OCCOC(=O)C=C1CCSCC1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1ccc(SCC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ccc(cc2CCC(=O)N1CCC)NC(N[C@@H]1C(C)(C)[C@@H]2[C@H]1CCO2)=O ### Response: CCCN1C(=O)CCc2cc(NC(=O)N[C@H]3[C@@H]4CCO[C@@H]4C3(C)C)ccc21
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc(S(=O)(=O)NCC[C@@H](O)c2ccccc2)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H](C)n1nccc1NC(=O)C(=O)N1CCc2cc(F)ccc2C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(-n2c(C[NH+](CCC)CC(NC)=O)nnn2)cccc1 ### Response: CCC[NH+](CC(=O)NC)Cc1nnnn1-c1ccccc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CSc1nncn1-c1ccccc1F)N1CCN(CC(=O)N2CCCC2)CC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CNC(=O)C1CCCC1)Nc1nc(C[NH+]2CCCCCC2)cs1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(Cl)cccc(c1)NC(N[C@H](CCC(OCC)=O)C)=O ### Response: CCOC(=O)CC[C@H](C)NC(=O)Nc1cccc(Cl)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [1*]C(=O)c1ccc(CC)cc1 ### Response: CCc1ccc(C(=O)Nc2ccc(OC)c(S(=O)(=O)N3CCOCC3)c2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)c1ncccc1C(=O)N(Cc1ccccc1C(F)(F)F)C1CC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O[C@H](C[C@H]1CCC[NH+]1Cc1cnc(-c2cccs2)s1)c1ccco1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(NCc1ccon1)c1sccc1Br ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1OCC[NH+]1CCC(CC(=O)[O-])CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? O=C(c1c[nH]c(=O)[nH]1)N1CCC[C@@H](c2nc(-c3cccs3)cc(C(F)(F)F)n2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)C1CCN([5*])CC1 ### Response: CCOc1ccc([C@H]2CCCN2C(=O)C2CCN(C(N)=O)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CS(=O)(=O)/N=C(\[O-])CC(C)C Fragment 2: [16*]c1ccc([N+](=O)[O-])cc1 ### Response: CC(C)C/C([O-])=N/S(=O)(=O)Cc1ccc([N+](=O)[O-])cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCS[C@H]1CC[C@@H]([NH+](C)Cc2c(Cl)nc3sccn23)C1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNC(=O)c1cccc(NS(=O)(=O)c2cccc(F)c2)c1C ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCn1cnc2ccccc2c1=O)N(CC(F)(F)F)C1CCOCC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1nc(C(=O)N[C@H](C)c2ccccc2)no1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H](NC(=O)[C@H]1CC=CCC1)c1ccc(F)c(F)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@H]1CN(C[C@@H](CC)CS)CCO1)C ### Response: CC[C@@H](CS)CN1CCO[C@@H](CC)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)COc1ccc([C@H](C)[NH2+]C2C[C@H](C)O[C@@H](C)C2)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c12n(cccc1C)c(=O)c1cc(C(=O)OCC)c(=NC(=O)c3occc3)n(c1n2)C[C@@H]1OCCC1 ### Response: CCOC(=O)c1cc2c(=O)n3cccc(C)c3nc2n(C[C@H]2CCCO2)c1=NC(=O)c1ccco1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1nn(C)c2ncc(NC(=O)c3ccc(C(=O)OC(C)(C)C)cc3)cc12 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2NC3=C([C@H](Nc2cc1)c1ccc(OC(CC)=O)cc1)C(=O)CC(C)(C3)C ### Response: CCC(=O)Oc1ccc([C@H]2Nc3ccccc3NC3=C2C(=O)CC(C)(C)C3)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(C)=O Fragment 2: [5*]N([5*])CC ### Response: CCN(C(C)=O)c1nc(CN2C[C@@H](C)O[C@H](c3ccccc3)C2)cs1
functional_group
### Instruction: Does the molecule contain a thiol group? Cc1cc2cc(CCNC(=O)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2cc1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]([8*])O Fragment 2: [6*]C(N)=O ### Response: NC(=O)[C@H]1COCCN1C[C@H](O)c1c(F)cccc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC(C)(C)C)ccc(cc1)C(N1CCN(CC1)C(C1CCCC1)=O)=O ### Response: CC(C)(C)Oc1ccc(C(=O)N2CCN(C(=O)C3CCCC3)CC2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[C@H](C)COc1c(F)cc(C[NH3+])cc1F ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH+]1([C@@H]2CCC[C@H]([NH2+]C)C2)[C@H](CCC1)C ### Response: C[NH2+][C@H]1CCC[C@@H]([NH+]2CCC[C@@H]2C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. O1[C@@H]2CCC[C@@H](NC(N[C@@H](c3oc(CC)cc3)COC)=O)[C@H]2CC1 ### Response: CCc1ccc([C@@H](COC)NC(=O)N[C@@H]2CCC[C@H]3OCC[C@H]23)o1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C)c1ccc(CCNC(=O)NC[C@@H]2CCC[C@@H]2O)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cn(c([C@@H]2CCCN(C2)C(=O)NCCc2ccc(cc2)OC)n1)C ### Response: COc1ccc(CCNC(=O)N2CCC[C@@H](c3nncn3C)C2)cc1
functional_group
### Instruction: Does the molecule contain a amide group? CC[C@@H](C)C[C@H](C)NC(=O)Cc1c(C)noc1Cl ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1csc(CC(=O)N2CCN(c3nc(C(F)(F)F)nc4ccccc34)CC2)n1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=O)c1ccc(Cl)cc1F)c1ccc(N)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. N(NC(c1ccc(o1)Br)=O)C(CNC(C1CCCCC1)=O)=O ### Response: O=C(CNC(=O)C1CCCCC1)NNC(=O)c1ccc(Br)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)c1ccc(C#N)cc1 Fragment 2: [5*]N([5*])CC ### Response: CCN(C(=O)c1cccc2cc[nH]c12)[C@@H](C)c1ccc(C#N)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](Nc1cnc(cc1)[N+](=O)[O-])(CC(C)(OC)C)C ### Response: COC(C)(C)C[C@H](C)Nc1ccc([N+](=O)[O-])nc1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(N[C@H]1CC[NH2+]C1)[C@H]1CC=CCC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc2c(=O)c(C(=O)Nc3ccc(NC(C)=O)cc3)cn(C)c12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1C Fragment 2: [4*]Cc1nnc([14*])o1 ### Response: Cc1ccccc1-c1nnc(CSc2nnc(N)s2)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1c(NC(=O)C(C)(C)C)sc2c1CCN(Cc1ccccc1)C2 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(nn(CN2CCN(CC2)C(OCC)=O)c(n1C)=S)-c1occc1 ### Response: CCOC(=O)N1CCN(Cn2nc(-c3ccco3)n(C)c2=S)CC1
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(OCC(=O)N/N=C\[C@H]2CC=CCC2)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@@H](c1ccccn1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@](O)(CNc1ccc(C#N)cc1F)c1ccco1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc([C@@H](C)N[C@H]2CCN(CC(F)(F)F)C2=O)c(OC)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Clc1ccc(-c2ccc(-c3ccccc3)cc2)nn1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1CCCO1 Fragment 2: [16*]c1ccc(Cl)c2ccccc12 ### Response: [NH3+][C@@H](CC[C@@H]1CCCO1)c1ccc(Cl)c2ccccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCCC1=c2ccccc2=[NH+]C1)Nc1nc2ccccc2s1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCCc1ccc(Cl)cc1Cl)c1ccccc1O ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)c1cc[n+](C2=C([O-])C(=[OH+])N(Nc3ccccc3)C2=O)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C[NH+]1CCCCC1)NC(=O)c1cccs1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=S(=O)(c1ccc(CNc2nc3ccccc3o2)cc1)N1CCCCC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2C[C@H]([C@@H](O)c2cc1OC)[NH+]1CCC[C@@H](C1)OCC ### Response: CCO[C@H]1CCC[NH+]([C@@H]2Cc3ccc(OC)cc3[C@@H]2O)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)CC(=O)C([C@H]2[C@H]3C(=O)CC(C)(C)C[C@H]3O[C@H]2Cc2ccccc2)=C([O-])C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(CCCN(C([C@H](C)Cn2c(ncc2)C)=O)C1)n1nc(ccc1=O)-c1sccc1 ### Response: Cc1nccn1C[C@@H](C)C(=O)N1CCC[C@H](n2nc(-c3cccs3)ccc2=O)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1OCCN1c1ccc(NS(=O)(=O)CCc2ccccc2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? COCCOc1ccccc1N1CCN(C(=O)[C@H]2CCCc3ccccc32)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[4*] Fragment 2: [1*]C(=O)NCC[4*] ### Response: N#Cc1ccc(OCCNC(=O)N2CC[NH+](C3CCCC3)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)CC Fragment 2: [11*]Sc1cc(C)c2ccccc2n1 ### Response: CCS(=O)(=O)NCCSc1cc(C)c2ccccc2n1