task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)C(=O)NCc2ccc(F)c(C)c2)c(Cl)n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? CC(=O)Oc1ccc(/C=c2/sc3nc(/C=C/c4ccc(F)cc4)nn3c2=O)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? C[C@H](c1cccc(F)c1)N1CCN(C(=O)C[C@H]2CCOc3ccccc32)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccc(COc2coc(CO)cc2=O)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](C)c1nccs1 Fragment 2: [5*]NC1=[NH+]CCC1 ### Response: C[C@@H](NC1=[NH+]CCC1)c1nccs1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc([14*])o1 Fragment 2: [8*]CCO ### Response: OCCc1ccc(-c2ccc(Cl)cc2)o1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(Br)ccc1NC(=O)CN(C)C(=O)CCn1cnc2ccccc2c1=O ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [1*]C(=O)CS[11*] ### Response: O=C(CSCC(=O)N1CCOCC1)NCc1ccccc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]1CN([5*])CCO1 Fragment 2: [4*]C[C@H]1CCC[C@@H](C)C1 ### Response: C[C@@H]1CCC[C@H](C[NH2+]C[C@@H]2CN(C3CC3)CCO2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(SCCC(=O)Nc2ccc(C(=O)N(C)C)cc2)cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(=O)oc2ccc([N-]S(=O)(=O)c3ccc(Cl)s3)cc21 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccnn1CC Fragment 2: [5*]N(C)C[8*] ### Response: CCn1nccc1CN(C)C(=O)c1ccccn1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12cc(C(=O)Nc3sc(c(C)c3)C([O-])=O)ccc2ncs1 ### Response: Cc1cc(NC(=O)c2ccc3ncsc3c2)sc1C(=O)[O-]
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1nnc(Cn2ccc(C(=O)C(C)C)c2)o1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccccc1NC(=O)COC(=O)c1c2c(nc3ccccc13)CC[C@@H](C)C2 ### Response: 4
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccccc1NC(=O)C(=O)N[C@H](c1ccc(F)cc1)c1nccn1C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CCC[NH+]1CCC(NC(=O)NCCC(=O)N(C)C)CC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(C(=O)Nc2ccc(N3CCOCC3)cc2)c(O)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? O=C(CC1C[C@H]2CC[C@@H](C1)[NH2+]2)NCC1CCOCC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H]([NH+](CC1)CC)CN(C)c1n(C)nc(c1N)CCC ### Response: CCCc1nn(C)c(N(C)C[C@H]2CCC[NH+]2CC)c1N
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(=O)CS[C@@H](N1c1ccc(C(C)C)cc1)c1c(OC)cccc1 ### Response: COc1ccccc1[C@H]1SCC(=O)N1c1ccc(C(C)C)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ncc(C[NH+]2CCC[C@@H](C(=O)Nc3ccc(-c4ccco4)cc3)C2)s1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C([8*])CC Fragment 2: [14*]c1n[nH]c(=S)n1/N=C/c1cccc([N+](=O)[O-])c1 ### Response: CC[C@@H](c1ccc2c(c1)CCCC2)c1n[nH]c(=S)n1/N=C/c1cccc([N+](=O)[O-])c1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1noc(C)c1[C@H](C)NS(=O)(=O)CCCCC#N ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(c(c1)Cl)Cl)[C@@H](NC(C[NH+]1CCC2(CC1)OCCO2)=O)C ### Response: C[C@H](NC(=O)C[NH+]1CCC2(CC1)OCCO2)c1ccc(Cl)c(Cl)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC([6*])=O Fragment 2: [16*]c1ccc(Cl)cc1[16*] ### Response: CC(=O)NCc1ccc(C(=O)COc2ccc(Cl)cc2C(N)=O)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccccc1-c1cccc(C(=O)N(C)CCC(F)(F)F)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H](OC[C@@H](O)COc1ccc2c(nccn2)c1)c1ccc(Cl)cc1 ### Response: C[C@@H](OC[C@@H](O)COc1ccc2nccnc2c1)c1ccc(Cl)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H](C)CN(C)C(=O)Cn1c(-c2scnc2C)nc2ccccc21 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC1Oc1nccc(C[NH2+]Cc2ccc(Br)cc2)c1 ### Response: Brc1ccc(C[NH2+]Cc2ccnc(OC3CCC3)c2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=c1ccn(CCC(=O)Nc2cccc(c2)-c2nc3sccn3c2)c(=O)[nH]1 ### Response: O=C(CCn1ccc(=O)[nH]c1=O)Nc1cccc(-c2cn3ccsc3n2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1[16*] Fragment 2: [8*]C(F)(F)F ### Response: O=C(N[C@H](C(=O)[O-])c1ccccc1C(F)(F)F)c1cscn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(C)[nH]c2ccccc12 Fragment 2: [8*]CC/N=C(/c1ccc(F)cc1)C1C(=O)N(C)C(=O)N(C)C1=O ### Response: Cc1[nH]c2ccccc2c1CC/N=C(/c1ccc(F)cc1)C1C(=O)N(C)C(=O)N(C)C1=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn(Cc2ccccc2)c(C)c1NC(=O)CSc1nnc(-c2cc(Cl)ccc2O)n1C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc([14*])nn1C Fragment 2: [4*]Cc1cnn([9*])c1 ### Response: CC(C)c1nc(NC(=O)NCc2cnn(-c3ccccc3)c2)n(C)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1cccc2s/c(=N\C(c3c(nn(C)c3)OC)=O)n(CCOC)c21 ### Response: COCCn1/c(=N/C(=O)c2cn(C)nc2OC)sc2cccc(F)c21
functional_group
### Instruction: Does the molecule contain a halide group? CCCC[C@@H](CC)[C@@H](Br)Cc1ccccn1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCOC(=O)C(C)(C)c1nc(-c2ccccc2)no1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1occc1-c1nnc(CCC(=O)N[C@@H]2CCS(=O)(=O)C2)o1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ccccn2c(c(n1)Cl)/C=C/C(=O)O[C@H]([C@H]1CCOC1)C ### Response: C[C@H](OC(=O)/C=C/c1c(Cl)nc2ccccn12)[C@H]1CCOC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)NC(=O)Nc1cccc(C(=O)N(C)Cc2nnc(C3CC3)n2C)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(C)C Fragment 2: [1*]C(=O)c1cc(C)nn1CC ### Response: CCn1nc(C)cc1C(=O)Nc1ccc(C(=O)NC(C)C)c(C)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(CCCS(C)(=O)=O)C(=O)C[C@@H]1CCCCC1(C)C ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(OC)cc(N2C[C@H](C(=O)N3CCC[C@@H]4CCC[C@@H]43)CC2=O)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN[C@@H](c1ccccc1C)C1([NH+]2CCCC2)CCCC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc([C@H]2CN(C(=O)c3cccs3)C[C@H]2C(=O)NCC2CC2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(SCC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1C=C(c2ccc(OC)c(OC)c2)N=N1 Fragment 2: [5*]N/C(=N/c1ccccc1C)SC ### Response: COc1ccc(C2=C[C@H](N/C(=N/c3ccccc3C)SC)N=N2)cc1OC
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1cccc(Cc2nnc(NC(=O)NCc3cccs3)s2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Oc1ccc(C(=O)/N=c2\sccn2Cc2ccccc2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(N2CC[NH2+]C[C@@H]2C(=O)N)nn2cccc(Br)c12 ### Response: NC(=O)[C@H]1C[NH2+]CCN1c1nc2c(Br)cccn2n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(N2CCC([NH2+][C@@H]3CC[C@@H]3NC(=O)CN3CCOC3=O)CC2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cc([16*])cn1 Fragment 2: [7*]C([O-])C[8*] ### Response: N#C/C(C(=O)NC1CCCC1)=C(/[O-])Cc1cnn(-c2ccccc2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12N(C)C[C@H](N(C(N[C@H]3[C@H]4CCCC[NH+]4CC3)=O)Cc1cccc2)C ### Response: C[C@@H]1CN(C)c2ccccc2CN1C(=O)N[C@@H]1CC[NH+]2CCCC[C@H]12
canonicalization
### Instruction: Canonicalize the following SMILES string. C[NH+]1CCC(CC1)N(C)Cc1cnc(Cl)s1 ### Response: CN(Cc1cnc(Cl)s1)C1CC[NH+](C)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [14*]c1ccc(C)c[nH+]1 ### Response: Cc1ccc(N2CC[C@H](N3CCOCC3)[C@H](CCC(=O)[O-])C2)[nH+]c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(CC[C@H](C(N[C@@H](c2ccncc2)CC)=O)C)cc(c1)F ### Response: CC[C@@H](NC(=O)[C@H](C)CCc1cccc(F)c1)c1ccncc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CCCO)NC(=O)c1cc(Br)cnc1Cl ### Response: 5
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CSC[C@@H](C)NC(=O)NCc1ccc(Br)s1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? CC[C@@H](CSC)N(C)C(=O)c1cc(F)c(F)c(F)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(c1ccccc1Cl)N1CCN(C2CCSCC2)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccc1OC Fragment 2: [1*]C(=O)[C@@H]1CS[C@@]2(C)CCC(=O)N12 ### Response: COc1ccccc1NC(=O)[C@@H]1CS[C@@]2(C)CCC(=O)N12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nn(C)cc1CNC(=O)N1CC[C@@H](S(=O)(=O)NC(C)C)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(C(F)F)c(COc2cc3c(OCO3)cc2)ncc1 ### Response: FC(F)n1ccnc1COc1ccc2c(c1)OCO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc([C@H](C)NC(=O)C2CC=CC2)c(C)o1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(S(=O)(=O)CC(=O)NC)nc(C)c1C Fragment 2: [15*]C1CCCCC1 ### Response: CNC(=O)CS(=O)(=O)c1nc(C)c(C)n1C1CCCCC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nn1cnc2ccccc21)[C@@H]1CCCN1S(=O)(=O)c1ccc(F)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1nc2ccccc2nc1C(=O)Nc1ccccc1C(F)(F)F ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H](O)C[8*] Fragment 2: [10*]N1C(=O)N(C)C2(CCCCC2)C1=O ### Response: CN1C(=O)N(C[C@H](O)COCc2ccccc2F)C(=O)C12CCCCC2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(Cl)ccc1NC(=O)C(=O)N/N=C/c1ccc(Cl)c(Cl)c1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCCCNC(=O)N[C@@H]1CCC[C@@H](CC)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(COc1c(C)cc(cc1)C)N/N=C/c1cc(I)c(OC)cc1 ### Response: COc1ccc(/C=N/NC(=O)COc2ccc(C)cc2C)cc1I
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(cccc2OCc2ccc(C(=O)Nc3ccc(cc3)S(=O)(N)=O)cc2)CC(O1)(C)C ### Response: CC1(C)Cc2cccc(OCc3ccc(C(=O)Nc4ccc(S(N)(=O)=O)cc4)cc3)c2O1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[NH2+][C@]1(CCC[C@H]1CCSc1sccn1)C([O-])=O ### Response: C[NH2+][C@@]1(C(=O)[O-])CCC[C@H]1CCSc1nccs1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)OC(=O)[C@H]1CN(C(c2cc(ccc2N(C)C)[N+]([O-])=O)=O)CCC1 ### Response: CCOC(=O)[C@@H]1CCCN(C(=O)c2cc([N+](=O)[O-])ccc2N(C)C)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@@H]([NH2+]C[C@](C)(O)C[NH+](C)C)c1c(Cl)cccc1Cl ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[C@@]2(CCCN([10*])C2=O)C1 Fragment 2: [8*]CCO ### Response: Cc1cc2c(N3CC[C@@]4(CCCN(CCO)C4=O)C3)ncnc2s1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C)n2nc(C(=O)N[C@@H](C)c3ccc(C)o3)nc2n1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(N)c(Oc2cccc(N(C)C)c2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)[C@H]2CCCN(c3nnc(-n4cccc4)s3)C2)c(Cl)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)S(=O)(=O)c1ccc(C(=O)NC[C@H](c2ccco2)[NH+](C)C)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCOC2(CCCC2)C1 Fragment 2: [3*]O[C@@H]1CCOC2(CCCC2)C1 ### Response: [NH3+]CC1CC(O[C@@H]2CCOC3(CCCC3)C2)C1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1noc(C)c1CCC[NH2+]Cc1ccc(Cl)nc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(cc(c1CC)NC(c1cc(c(s1)S(=O)(N)=O)OC)=O)CC ### Response: CCc1ccc(CC)c(NC(=O)c2cc(OC)c(S(N)(=O)=O)s2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH+]1CC[C@@H](CNC(=O)C(=O)Nc2ccc(C)c(NC(C)=O)c2)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C([4*])(C)C Fragment 2: [1*]C(=O)C(C)(C)O[3*] ### Response: Cc1cccc(N2CCN(C(=O)C(C)(C)Oc3ccc(Cl)cc3)CC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC[C@@H](C)NC(=O)[C@@H](C)N1C(=O)c2cc(Cl)c(Cl)cc2C1=O ### Response: 3
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1nc2cc3c(cc2n1C[C@H](O)COCc1cccs1)OCCO3 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1noc(C)c1CC(=O)N[C@H]1C[C@H]2CCCc3cccc1c32 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c([C@@H]2[C@H](/C(=N\O)C)C2)ccc(OC)c1 ### Response: COc1ccc([C@H]2C[C@H]2/C(C)=N\O)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COC(=O)Cn1c(SC)nc2ccccc21 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(C(C)C)cnnc1S[C@H](c1cc(c(Cl)cc1)Cl)C ### Response: CC(C)n1cnnc1S[C@@H](C)c1ccc(Cl)c(Cl)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C(=O)Nc2nc(-c3ccc(OC)c(OC)c3)ns2)cc1Cl ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCO Fragment 2: [5*]N[C@@H]1CCC[C@H]1[15*] ### Response: O=C(NCCO)N[C@@H]1CCC[C@H]1c1ccccc1C(F)(F)F
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2c(=O)cc(C(=O)N3CCN(c4cccc(Cl)c4)CC3)oc2c1C ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc([C@H]([NH2+]Cc2nc(-c3ccco3)no2)c2ccccc2)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCCC1 Fragment 2: [14*]c1nccn1C ### Response: COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCN(CC(=O)NC)C(=O)Cc1cccc(Cl)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@@H]1CCC[NH+](Cc2ccc(CNC(=O)[C@@H]3CSCN3C(=O)C3CCCC3)cc2)C1 ### Response: No