task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCn1cc(/C=C(\C#N)C(=O)Nc2ccccc2)c2ccccc21 ### Response: 4
functional_group
### Instruction: Does the molecule contain a nitro group? CC[C@@](C)([NH3+])C(=O)N(C)CCOc1cc(C)cc(C)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1N=C([O-])/C(=C\c2ccc([N+](=O)[O-])cc2Cl)C(=O)N1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCCN(C(=O)NCc2ccc(N3CCOCC3)c(F)c2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? O=C([O-])[C@@H]1C[NH2+]CCN1C(=O)N[C@@H]1CCOC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1c(-c2ccc(F)cc2)nn2c1N=C(O)C[C@H]2C(=O)Nc1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCc1cc([16*])cc[nH+]1 Fragment 2: [5*]NCC ### Response: CCNc1cc[nH+]c(COc2ccc(C)cc2Br)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N1CC[C@@H](C)C[C@@H]1C Fragment 2: [1*]C(=O)CC[4*] ### Response: Cc1cccc(NC(=O)CCNC(=O)N2CC[C@@H](C)C[C@@H]2C)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(S(=O)(=O)N2CCOc3ccccc32)cc1C(N)=O ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1nn(C)cc1CNC(=O)N[C@@H](CC)C(C)(C)c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1cc(OC)c(cc1NC(c1c(n(-c2ccc(C)c(c2)C)nc1)C1CC[NH2+]CC1)=O)Cl)C ### Response: COc1cc(OC)c(NC(=O)c2cnn(-c3ccc(C)c(C)c3)c2C2CC[NH2+]CC2)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. C(#N)c1ccccc1O[C@H](C)C(N1C[C@H](C(F)(F)F)CCC1)=O ### Response: C[C@@H](Oc1ccccc1C#N)C(=O)N1CCC[C@@H](C(F)(F)F)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1cc(C[NH+]2CCCC[C@@H]2CCO)ccc1O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc(C)ccc1NCc1ncn(-c2ccccc2)n1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(CC[NH+](C)C)C(=O)N1CC(n2cc(C(=O)[O-])nn2)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1ccc(S(=O)(=O)Nc2cccc(C(=O)NCc3cccc(C)c3)c2C)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc2c(c1)OCO2 Fragment 2: [5*]NCc1ccc2c(c1)OCO2 ### Response: CC1CCN(C(=O)[C@@H]2CCCN(C(=O)NCc3ccc4c(c3)OCO4)C2)CC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc([C@H](CNC(=O)Cn2c(=O)oc3ccccc32)[NH+]2CCCC2)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nc1ccc(cc1)CSc1[nH]ncn1)c1sc2c(cccc2c1Cl)[N+]([O-])=O ### Response: O=C(Nc1ccc(CSc2ncn[nH]2)cc1)c1sc2c([N+](=O)[O-])cccc2c1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C(=O)O[C@H]1C(=O)N(c2ccccc2)CC1(C)C)N1C(=O)c2ccccc2C1=O ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc(=O)oc2ccc(CC)cc12 Fragment 2: [4*]Cc1ccc(OC)cc1 ### Response: CCc1ccc2oc(=O)cc(C[NH+]3CCN(Cc4ccc(OC)cc4)CC3)c2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(sc1-c1onc(C(=O)NCC(NC(C)(C)C)=O)c1)Cl ### Response: CC(C)(C)NC(=O)CNC(=O)c1cc(-c2ccc(Cl)s2)on1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC1=C(C#N)C(=O)N(C2CCCCC2)C(=O)/C1=C\Nc1ccc(Cl)cc1Cl ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1c(cc(cc1)N(C)C)C)NC(=O)C[C@H](c1cccc(c1)F)O ### Response: Cc1cc(N(C)C)ccc1CNC(=O)C[C@@H](O)c1cccc(F)c1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)CC[C@H](C)NC(=O)Nc1cccc(Cl)c1 ### Response: 5
ring_counting
### Instruction: Count the five-membered rings in the following molecule. NS(=O)(=O)c1ccc(Cl)c(C(=O)OCc2csc(-c3ccc(F)cc3)n2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(CNC(=O)[C@@H]2CCCN(c3ncnc4onc(C)c34)C2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](C(=O)N1CCCC1)N1CCN(C(=O)Nc2ccc3c(c2)CCC3)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H]1CC[C@H](C)N1C(=O)c1cnc(Oc2ccccc2)cn1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCCCCC Fragment 2: [5*]Nc1ccc(Cl)c([16*])c1 ### Response: CCCCCCC(=O)Nc1ccc(Cl)c(C(=O)[O-])c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nnc(CC)s1 Fragment 2: [4*]Cc1ccccc1 ### Response: CCc1nnc(NC(=O)[C@H]2CC(=O)C(OCc3ccccc3)=CO2)s1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccccc1C[NH+]1CCC[C@H](C(=O)Nc2ccc(Cl)cn2)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c(C[NH+]2CC3(CCC3)C2)cc1)N ### Response: Nc1ccccc1C[NH+]1CC2(CCC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(O[C@@H](C)CNC(=O)N[C@H]2CCC[C@@]2(C)CO)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cc1occc1C(=O)Nc1ccnc2ccc(Br)cc12 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1[nH+]c(C2CCN(C(=O)CCn3cc[nH+]c3C)CC2)nc(N2CCOCC2)c1C ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc(Cl)c(NC(=O)c2ccc3cc[nH]c3c2)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]1CCCC(C)(C)[C@@H]1[15*] Fragment 2: [5*][NH+]1CC[C@H]([15*])C1 ### Response: CC[NH2+][C@@H]1[C@H](C[NH+]2CC[C@H](COC)C2)CCCC1(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(C)(=O)=O Fragment 2: [5*]Nc1cc(Br)ccc1Br ### Response: CS(=O)(=O)N1CCc2cc(C(=O)Nc3cc(Br)ccc3Br)ccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCS(=O)(=O)Nc1ccccc1[C@@H]1N=C(CNC(=O)[C@@H]2N=NC3=C2CCCC3)[C@H](C)O1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cnc(S(=O)(=O)Cc2noc3c2CCCC3)nc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]SCC Fragment 2: [1*]C(=O)N([5*])C ### Response: CCSC[C@@H](C)N(C)C(=O)N[C@H]1CCC[C@H](S(C)(=O)=O)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1CCc2c(sc(NC(=O)[C@@H]3CCOc4ccccc43)c2C#N)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)OC(=O)N1CCC[C@H](NC(=O)C[C@H](O)c2cccc(F)c2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. OC(C)(C)C[NH+](CCCCC([O-])=O)C ### Response: C[NH+](CCCCC(=O)[O-])CC(C)(C)O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1cccc(F)c1 Fragment 2: [1*]C(=O)[C@@H](C)O[3*] ### Response: COc1ccccc1[C@@H](C)NC(=O)[C@@H](C)Oc1cccc(F)c1
functional_group
### Instruction: Does the molecule contain a aldehyde group? COc1cc([C@H](C)NS(=O)(=O)CC2CCC2)ccc1F ### Response: No
functional_group
### Instruction: Does the molecule contain a phenol group? CC1CCC(N(C)C(=O)CN2C(=O)c3ccccc3S2(=O)=O)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? CC[C@@H](CN1CC[NH+](C)CC1)NC(=O)Cc1c(C)[nH]c2ccc(Cl)cc12 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1CS(=O)(=O)[C@@]2(CCS(=O)(=O)C2)N1c1ccccc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? O=C(Nc1cccc(Cl)c1)N1CCC[C@@H](OCc2cccc(F)c2F)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)C[C@@H]([15*])C1=O Fragment 2: [8*]CC(=O)[O-] ### Response: CC[C@H]1CCCC[NH+]1[C@@H]1CC(=O)N(c2nc(CC(=O)[O-])cs2)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc([C@H](C)NC(=O)/C=C/c2cnn(C)c2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@@H](O)[C@@H](O)C1 Fragment 2: [1*]C(=O)N1C[C@@H](O)[C@@H](O)C1 ### Response: O=C(Nc1ccc([N+](=O)[O-])cc1)N1C[C@@H](O)[C@@H](O)C1
functional_group
### Instruction: Does the molecule contain a ester group? CN(Cc1ccccc1)C(=O)[C@@H]1CCC[NH+](Cc2ccccc2F)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? NC(=O)[C@H]1CCCN(C(=O)CNc2ccccc2C#Cc2ccccc2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1Cc2cc3ccccc3nc2[C@@H]1C Fragment 2: [1*]C(=O)c1cc(OC)c(OC)c(OC)c1 ### Response: COc1cc(C(=O)N2Cc3cc4ccccc4nc3[C@@H]2C)cc(OC)c1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccn1C Fragment 2: [9*]n1nc(S[11*])nc1[14*] ### Response: Cn1cccc1C(=O)NC(=O)CSc1nc(C2CC2)n(-c2ccccc2)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H](CCO)NC(=O)N[C@@H](c1ccc(Cl)cc1)C1CCC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1noc([14*])n1 Fragment 2: [8*]C[S@](=O)CCCC ### Response: CCCC[S@@](=O)Cc1nc(-c2cc(Br)cs2)no1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cncn1 Fragment 2: [3*]O[C@@H]1C[C@H]2CC[C@@H]1C2 ### Response: O=C(O[C@@H]1C[C@H]2CC[C@@H]1C2)c1ccccc1Cn1cncn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(CN2CCc3c(nc(N4CCCCC4)[nH]c3=O)C2)ccc1O ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1c(Br)cc(Br)cc1/C=C/C[NH2+]C ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ncccn1 Fragment 2: [1*]C(=O)C[4*] ### Response: COC(=O)[C@H]1CC[NH+](CC(=O)Nc2ncccn2)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)(C)OC(=O)N[C@H](C(N)=O)C1CCCCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCc1ccc(F)cc1 Fragment 2: [7*]Cc1cccnc1 ### Response: O=C1/C(=C/c2cccnc2)Oc2c1ccc1c2CN(CCc2ccc(F)cc2)CO1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccc(N2CCC(N3CCC[C@@H](CCC(=O)N4CCOCC4)C3)CC2)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(OCC(F)F)ncc1C(=O)N[C@@H](CCC)C#N ### Response: CCC[C@@H](C#N)NC(=O)c1ccc(OCC(F)F)nc1
functional_group
### Instruction: Does the molecule contain a halide group? O=S(=O)(c1cccc2cccnc12)N1CCCSC[C@@H]1C[NH+]1CCCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2[nH]c(=O)[nH]c2c1 Fragment 2: [8*][C@@H](O)[C@@H]1CCO[C@H]1C ### Response: C[C@@H]1OCC[C@H]1[C@H](O)c1ccc2[nH]c(=O)[nH]c2c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(C(=O)NC2(CC(=O)[O-])CCC2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C(F)F)n2ncc(C(=O)Nc3cnn(Cc4ccc(Cl)cc4Cl)c3)c2n1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1CCC(N(C(=O)c2cn(CC(N)=O)nn2)C2CC2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitrile group? CCOC(=O)C1=C(C)N(CCc2cccs2)C(=O)N[C@H]1c1cccc(C#N)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)C[C@@H]1CCCCN1S(=O)(=O)c1c[nH]cn1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#Cc1c(Cl)nsc1NCCCCN1CCOCC1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCC[C@@H](c1cccnc1)n1cnc2sc3c(c2c1=O)CCNC3 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])CC1CC1 Fragment 2: [4*]CC1CC1 ### Response: CCc1nn(C)cc1C(=O)N(Cc1ccc(O)cc1)CC1CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH+]1c(cccc1)N1CCN(c2c(CNC([C@@H]3CC=CCC3)=O)ccc[nH+]2)CC1 ### Response: O=C(NCc1ccc[nH+]c1N1CCN(c2cccc[nH+]2)CC1)[C@@H]1CC=CCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](C)[C@H]1CC[C@H](NC(=O)Cn2nc(-c3ccccc3)ccc2=O)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc(-n2nc(S[C@H](C)C(=O)Nc3ccccc3C)ccc2=O)cc1Cl ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)c1ccccc1F Fragment 2: [16*]c1ccccc1F ### Response: O=C(Nc1cccc(Cl)c1)Nc1cc2c(cc1C(=O)c1ccccc1F)OCCO2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccccc1Cl Fragment 2: [12*]S(=O)(=O)c1ccc2ccccc2c1 ### Response: Cc1nn(Cc2ccccc2Cl)c(C)c1NS(=O)(=O)c1ccc2ccccc2c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(C)cc1N[C@@H](C)C(=O)NC1CCCCC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CC[NH+]1CC=C(c2ccc(O)cc2)CC1)Nc1cc(Cl)ccc1Cl ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(COCCNS(=O)(c1cc(F)c(C)cc1)=O)(F)F ### Response: Cc1ccc(S(=O)(=O)NCCOCC(F)(F)F)cc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc2ccccc2[nH]1 Fragment 2: [5*]N1CCC[C@H]([15*])C1 ### Response: CC(C)(C)C(=O)N1CCC[C@H](c2nc3ccccc3[nH]2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(F)c(c1F)[C@H](CC(N[C@H](C(N)=O)C(C)(C)C)=O)NC(C)=O ### Response: CC(=O)N[C@@H](CC(=O)N[C@H](C(N)=O)C(C)(C)C)c1c(F)cccc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC([4*])(C)C Fragment 2: [5*]N1CCN([5*])[C@@H](C)C1 ### Response: C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(N2C(=O)[C@@H](Cc3ccccc3)N=C2N2CCOCC2)cc1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1c2cc(Br)ccc2n2cn[nH]c(=O)c12 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCC[C@H]1CC Fragment 2: [12*]S(=O)(=O)c1ccc([16*])cc1 ### Response: CC[C@@H]1CCCCN1S(=O)(=O)c1ccc(N2C(=O)CCCC2=O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2[nH]c(C)c(C)c2c1 Fragment 2: [9*]n1c([14*])n[nH]c1=S ### Response: Cc1ccc(-n2c(-c3ccc4[nH]c(C)c(C)c4c3)n[nH]c2=S)c(C)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)CC[C@@H]1CCCN1C(=O)c1scnc1C1CC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C[NH+](C)CCS(C)(=O)=O)oc1C[NH3+] ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1C#N Fragment 2: [5*]N1CCN([5*])CC1 ### Response: N#Cc1ccccc1N1CCN(C(=O)c2cccnc2)CC1
functional_group
### Instruction: Does the molecule contain a ether group? COc1cccc(NCC(=O)Nc2cccc(C(=O)N3CCCCC3)c2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)n(CCC(=O)N2[C@H]3CC[C@@H]2c2cnc4cc(C)nn4c2C3)c(=O)n1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. [NH3+]C[C@H]1CCC[C@H]1S(=O)(=O)c1cccc(F)c1 ### Response: 1