task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1OCC[C@H]1C(=O)N(C)[C@@H](C)CS(C)(=O)=O ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[NH+](Cc2ccccc2C(N)=S)C[C@H]1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCNC(=O)c1ccccc1Cl)Nc1ccc(-c2ccccc2)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. s1c(cc(S(=O)(=O)N2CCN(Cc3[nH+]c4n(c3)cc(C)cc4)CC2)c1C)C ### Response: Cc1ccc2[nH+]c(CN3CCN(S(=O)(=O)c4cc(C)sc4C)CC3)cn2c1
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1occc1C(=O)Nc1cccc(-c2ccc3c(c2)CCO3)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. OCC[C@H]1C[NH+](Cc2ccncc2)CCN1Cc1ccccc1F ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(C)[nH]c2ccc(F)cc12 Fragment 2: [8*]CC(=O)/N=c1\[nH]nc2cc(C)ccn12 ### Response: Cc1ccn2/c(=N/C(=O)Cc3c(C)[nH]c4ccc(F)cc34)[nH]nc2c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccnc1C[C@@H](N[C@H]1CCSc2ccccc21)C(F)(F)F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1cnc(NC(=O)[C@H](C)Cc2c(C)nn(C)c2C)s1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(CSCC)cc1)C(=O)N1C[C@@H](C)OCC1(C)C ### Response: CCSCc1ccc(C(=O)N2C[C@@H](C)OCC2(C)C)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CO/N=C/c1ccc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(=O)c2c(nc(s2)SC)ncn1CC(NCC1CCCCC1)=O ### Response: CSc1nc2ncn(CC(=O)NCC3CCCCC3)c(=O)c2s1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC2(CCC1N(C)c1c3c(ccs3)ncn1)OCCO2 ### Response: CN(c1ncnc2ccsc12)C1CCC2(CC1)OCCO2
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)(c1ccccc1OS(c1cc(ccc1Cl)F)(=O)=O)F ### Response: O=S(=O)(Oc1ccccc1C(F)(F)F)c1cc(F)ccc1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1Cc2ccccc2N1c1nccc(OCC(=O)[O-])n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [5*]N[C@@H](C(=O)[O-])[C@@H](C)OC ### Response: CO[C@H](C)[C@@H](NC(=O)OCc1ccccc1)C(=O)[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(Cl)cc1F Fragment 2: [1*]C(=O)CCC ### Response: CCCC(=O)N1CCC[C@@H](C(=O)NNC(=O)c2ccc(Cl)cc2F)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(C[C@@H]1COc2ccccc2O1)C(=O)c1cccc(-n2cnnn2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)CN1C(=O)NC(C2CC2)(C2CC2)C1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@H](NC(=O)NCCn1cc([N+](=O)[O-])cn1)c1ccc(Cl)s1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCCN1CC(=O)N2[C@H](c3ccccc3OC)[C@H]3[NH+]=c4ccccc4=C3C[C@H]2C1=O ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? Fc1ccc([C@H]2Oc3ccc(Cl)cc3C3=C2[C@H](c2cccnc2)N2NC=NC2=N3)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCC[C@H](NC(=O)CN2CC[NH+](C/C=C/c3ccco3)CC2)C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cn1c(-c2ccco2)nn(C[NH+](C)CCc2ccccc2)c1=S ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cccc1)C[C@@H](NC(Nc1nc(c(s1)C)C)=O)C(OC(C)(C)C)=O ### Response: Cc1nc(NC(=O)N[C@H](Cc2ccccc2)C(=O)OC(C)(C)C)sc1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ncccc1NC(=O)C(=O)NCC[NH+]1CCC(C)CC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(F)ccc(Cl)c1)NC(c1c(nn(c1C)CCCl)C)=O ### Response: Cc1nn(CCCl)c(C)c1C(=O)Nc1cc(Cl)ccc1F
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)Nc1cc(C(=O)NCc2ccc(C[NH+]3C[C@H](C)C[C@H](C)C3)cc2)ccc1F ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH+]1CC[C@@H]([NH2+]CCCC(=O)N2Cc3ccccc3C2)[C@H](C)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cnc(C)s1 Fragment 2: [5*]N[C@H]([8*])c1ccccn1 ### Response: COc1ccccc1[C@@H](N[C@@H](C)c1cnc(C)s1)c1ccccn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N/C(=C/c1ccc(Br)cc1)C(=O)N1CCOCC1)c1ccc([N+](=O)[O-])cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitro group? CC(C)Cn1cc(NC(=O)C[C@H](NC(N)=O)c2cccs2)cn1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCN(c2nc(C(OC)=O)ccc2)CC[C@H]1c1ccccc1 ### Response: COC(=O)c1cccc(N2CCC[C@H](c3ccccc3)CC2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@@H]([NH3+])CCc1ccccc1Br ### Response: 5
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCOC(=O)[C@@H](C#N)c1c(F)c(F)c(Br)c(F)c1F ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCC[4*] Fragment 2: [16*]c1ccccc1 ### Response: Cc1cc(CNC(=O)CCC[NH+]2CCN(c3ccccc3)CC2)on1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [11*]Sc1ccc(Cl)cc1 ### Response: CSc1ccc2nc(NC(=O)CSc3ccc(Cl)cc3)sc2c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(O[C@@H](C)C(=O)N2CC[C@@H](C(=O)[O-])[C@@H]2C)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [3*]OC(C)C ### Response: CC(C)OC(=O)CN1C(=O)/C(=C/c2c(Cl)cccc2Cl)SC1=S
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccnc([14*])c1 Fragment 2: [3*]OC1CCC1 ### Response: NC(=O)Cc1ccccc1NC(=O)NCc1ccnc(OC2CCC2)c1
functional_group
### Instruction: Does the molecule contain a ketone group? O=S(=O)(Cc1ccccc1)/N=C(\[O-])CCOc1ccccc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(C)=O Fragment 2: [5*]NS(=O)(=O)c1ccc2c(c1)C[C@@H](C)N2[5*] ### Response: CC(=O)N1c2ccc(S(=O)(=O)N[C@H](Cc3ccccc3)C(=O)Nc3nc(C)cs3)cc2C[C@H]1C
functional_group
### Instruction: Does the molecule contain a amine group? O=S(=O)(NC1CC1)[C@H]1CCN(Cc2cnc(-c3ccccn3)s2)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccn(-c2ccc(Cl)cc2Cl)n1)c1cnns1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C1CS[C@@H](c2ccccc2)N1O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC(=O)Nc2ccc(Cl)cc2[C@@H]1c1ccccc1 Fragment 2: [1*]C(=O)c1c(F)cccc1Cl ### Response: O=C1CN(C(=O)c2c(F)cccc2Cl)[C@@H](c2ccccc2)c2cc(Cl)ccc2N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)NNC(=O)CCC(C)C Fragment 2: [16*]c1c(C)n[nH]c1C ### Response: Cc1n[nH]c(C)c1[C@@H]1CCCN1C(=O)NNC(=O)CCC(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(-c2nc(C(N[C@H]3CCCC[C@H]3[S@](=O)CC)=O)c(s2)C)o1 ### Response: CC[S@@](=O)[C@@H]1CCCC[C@@H]1NC(=O)c1nc(-c2ccco2)sc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(/C=C/C([O-])=O)c(OCc2nc(no2)C)ccc1OC ### Response: COc1ccc(OCc2nc(C)no2)c(/C=C/C(=O)[O-])c1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cnc(Oc2c(OC)cccc2)c([N+]([O-])=O)c1Nc1ccccc1C ### Response: COc1ccccc1Oc1ncnc(Nc2ccccc2C)c1[N+](=O)[O-]
functional_group
### Instruction: Does the molecule contain a amine group? COCc1nc(C)cc(N[C@@H]2CCC[C@H]2C(N)=O)n1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? CCOCCn1c(C(C)(C)C)cn2c3c(=O)n(C)c(=O)n(C)c3nc12 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(Cc2c(C(C)(C)C)n[nH]c2)[C@H](COCC1)C#N ### Response: CC(C)(C)c1n[nH]cc1CN1CCOC[C@@H]1C#N
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]([NH3+])c1ccn(CCCc2ccccc2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a thiol group? CC1(C)C[C@@H](NCc2cccnc2OCC(F)F)c2ccc(F)cc2O1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1C[NH+](Cc2c(C[NH3+])oc3ccccc23)C[C@H]1C ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(CC)(CO)NC(=O)Nc1cccc(-c2nnco2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [8*]Cc1ccccc1 ### Response: S=c1sc(SCc2ccccc2)nn1Cc1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc(CC)cc1 Fragment 2: [12*]S(=O)(=O)CC ### Response: CCc1ccc(C[NH+]2CCN(S(=O)(=O)CC)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]N(C)C(C)C ### Response: CC(C)N(C)C(=O)CN1CC[NH2+]C[C@@H]1C#N
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(sc2ncnc(c21)SCC(N(C)C1(C#N)CCC1)=O)C ### Response: Cc1sc2ncnc(SCC(=O)N(C)C3(C#N)CCC3)c2c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [5*]N[C@@H](C)CC[8*] ### Response: C[C@@H](CCc1ccccc1)NC(=O)c1n[nH]c(=O)c2ccccc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC2(CC1)OCCO2 Fragment 2: [3*]OCC ### Response: CCOc1ccc2[nH]c3c(N4CCC5(CC4)OCCO5)ncnc3c2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N(Cc1scc(n1)C(F)(F)F)C)c1c(O)c(ccc1)Br ### Response: CN(Cc1nc(C(F)(F)F)cs1)Cc1cccc(Br)c1O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2C)cc1Cl ### Response: COc1ccc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2C)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccccc1[C@H](OC(=O)c1ncnc(C)c1)C)N(C)C ### Response: Cc1cc(C(=O)O[C@H](C)c2ccccc2N(C)C)ncn1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C(C)(C)C)C(=O)NC[C@H](CC(=O)N1CCC(O)(CC1)C(F)(F)F)C ### Response: C[C@H](CNC(=O)OC(C)(C)C)CC(=O)N1CCC(O)(C(F)(F)F)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1c(c(F)ccc1)N1CC[C@@H](C1=O)Nc1ccc(C(N)=O)cc1 ### Response: NC(=O)c1ccc(N[C@H]2CCN(c3c(F)cccc3F)C2=O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)C(C)C Fragment 2: [5*]Nc1ccc2c(c1)CN([5*])CC2 ### Response: CC(C)S(=O)(=O)Nc1ccc2c(c1)CN(C(=O)c1cccs1)CC2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1=NO[C@](C)(CNC(=O)[C@H]2CCCO2)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(Cn1c(=O)oc2ccccc21)NC1=N[C@H](c2ccccc2)CS1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccccc1O[C@H](C)CNC(=O)N[C@H](C)C(C)(C)C ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH2+][C@H]1[C@H](CN2C[C@@H](C)O[C@@H](C)C2)CCC1(C)C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(C)c([14*])s1 Fragment 2: [16*]c1ccccc1 ### Response: Cc1nc(-c2ccccc2)sc1C(=O)[C@@H]1[C@H](c2ccccc2)C1(C#N)C#N
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1COc2c(cccc2OC)C1 Fragment 2: [4*][C@@H](C)c1cnc(C)s1 ### Response: COc1cccc2c1OC[C@H](N[C@@H](C)c1cnc(C)s1)C2
functional_group
### Instruction: Does the molecule contain a aldehyde group? C[C@H](C(=O)Nc1cccc([N+](=O)[O-])c1)[n+]1ccccc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1C)-n1nnnc1SCC(N(C)[C@H]1c2c(cccc2)CCC1)=O ### Response: Cc1cccc(-n2nnnc2SCC(=O)N(C)[C@@H]2CCCc3ccccc32)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nc(CC)n(CCC(=O)NC(N)=O)n1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C[C@@H]1CCC[C@@H](N(C)C(=O)NCc2cccc(Cn3cccn3)c2)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[8*] Fragment 2: [1*]C(=O)c1cccc(Cl)c1F ### Response: Cc1n[nH]c(C)c1CCOC(=O)c1cccc(Cl)c1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2cc(CNC(=O)N3CCC[C@H](O)C3)ccc2c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(-n2c3c(c(cc(n3)C)C(=O)N3[C@@H](CCCC3)CC)cn2)c(c1)F ### Response: CC[C@@H]1CCCCN1C(=O)c1cc(C)nc2c1cnn2-c1ccccc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H](C)CSC Fragment 2: [4*]CCC[8*] ### Response: CSC[C@@H](C)NC(=O)NCCCc1nc(C)no1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCCC[NH+]1Cc1nc(-c2cccc(Cl)c2)no1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H]1CCCC[NH+]1CC(=O)Nc1cccc(C(=O)NC2CC2)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CC1=C(C(=O)CSc2nnc(-c3c[nH]c4ccccc34)o2)C[C@H](C)N1CC(F)(F)F ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C1C[C@@H](c2cccs2)CC2=C1[C@H](c1c(Cl)cccc1Cl)n1ncnc1N2 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(NC(=O)CN(C)C(=O)c2cccc(N3CCCC3=O)c2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? CN(C)c1cccc(C(=O)OCC(=O)Nc2ccc(F)cc2F)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(Oc2cccnc2)n1)NC(N1CC2(CCCC2)OCC1)=O ### Response: O=C(Nc1ccc(Oc2cccnc2)nc1)N1CCOC2(CCCC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)ccc(c1)CC(OCC(Nc1c(C)c(C)ccc1)=O)=O ### Response: Cc1ccc(CC(=O)OCC(=O)Nc2cccc(C)c2C)cc1
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc([C@H]2C[C@@H](C(F)(F)F)n3nc(C(=O)NC4CCCCC4)cc3N2)cc1OC ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H]1CCC[C@@H]([NH2+]CCCC(=O)NC2CC2)CC1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)C(=O)[C@H]1CCCN1C(=O)c1ccccc1C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1CCC[C@H](C)C1 Fragment 2: [5*]N1CCOCC[C@@H]1C ### Response: C[C@H]1CCC[C@H](NC(=O)N2CCOCC[C@@H]2C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(NC(=O)CN(C)C(=O)c2cnn(-c3ccccc3)n2)c1C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)[C@H]1CCCN(c2ncnc(Nc3cccc4ccc(C)nc34)c2[N+](=O)[O-])C1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccccc1OCc1n[nH]c(SCC(=O)N2CCC(c3ccccc3)=N2)n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1ccc([C@H]2CSCCN2C(=O)c2ccc(NC(=O)C(C)C)cc2)o1 ### Response: No