task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CO[C@]1(C)C[C@@H]([NH+](C)CCN2C(=O)CNC2=O)C1(C)C ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)N1CC[C@H](NC(=O)C2C(C)(C)C2(C)C)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@H]([NH2+][C@H]1CCCc2c1cc(Br)cc2)CCO)SC ### Response: CSC[C@H](CCO)[NH2+][C@H]1CCCc2ccc(Br)cc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(NC(=O)Nc1cccc2cccnc12)C(N)=O ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(C[8*])cc1 Fragment 2: [1*]C(=O)c1ccc(Cl)c(Cl)c1 ### Response: O=C(Nc1ccc(CN2CCCC2=O)cc1)c1ccc(Cl)c(Cl)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2cnc(CCC(=O)N(C)C3CCOCC3)o2)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)cc(c(C)c1)NC(=O)CN1C(=S)S[C@@H](C1=O)CC ### Response: CC[C@H]1SC(=S)N(CC(=O)Nc2cc(C)ccc2C)C1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCO[C@]2(CCOC2)C1 Fragment 2: [3*]Oc1cccnc1N ### Response: Nc1ncccc1O[C@@H]1CCO[C@]2(CCOC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1Cl)CNC(COc1c(Br)cc(cc1)F)=O ### Response: O=C(COc1ccc(F)cc1Br)NCc1ccc(Cl)cc1
functional_group
### Instruction: Does the molecule contain a nitrile group? CCC(CC)(C(=O)c1ccco1)[NH+]1CCCC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(C1)N(CC)S(c1ccc2[nH]c(=O)[nH]c(=O)c2c1)(=O)=O ### Response: CCN(C1CCCC1)S(=O)(=O)c1ccc2[nH]c(=O)[nH]c(=O)c2c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)CCCN1C[C@@H](C)OC[C@@H]1c1ccccc1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)C([C@H](CNC(=O)C)[NH+](C)C)CC ### Response: CCC(CC)[C@H](CNC(C)=O)[NH+](C)C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[NH+](CCCNC(=O)[C@@H]1CCO[C@H]1C)C(C)C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccccc1[C@H]1N[C@@H](C[NH+]2CCC[C@@H]2c2nc3ccc(F)cc3[nH]2)[C@H](C)O1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(C)C)c(CO)sc(n1)N(CCCCC)C ### Response: CCCCCN(C)c1nc(C(C)C)c(CO)s1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCCC(=O)Nc1nnc(SCC(=O)N2[C@H](C)CCC[C@H]2C)s1 ### Response: No
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COC(=O)[C@@H]1CN(C(=O)c2cnns2)C[C@H]1C ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)[C@](O)(c1ccc(C(=O)[O-])cc1)c1ccc(C(F)(F)F)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c([C@@H]2CCC[NH+]2CCCOC(=O)NC(N)=O)cnn1C ### Response: 3
functional_group
### Instruction: Does the molecule contain a ester group? COc1cccc(O[C@@H]2CC[C@H]([NH3+])C2)n1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(CC(=O)NC[C@H](C2CC2)[NH+](C)C)cc1O ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H]1CC[C@@](C#N)([C@H](O)C2CC2)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])c1cc(-c2ccc(F)c(C(F)(F)F)c2)cnc1O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Oc1nc(ccc1N)Oc1cccc(Cl)c1Cl)CC ### Response: CCCOc1nc(Oc2cccc(Cl)c2Cl)ccc1N
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1N=[NH+]C(=S)N1/N=C/c1c(OC)cc(OC)cc1OC Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: COc1cc(OC)c(/C=N/N2C(=S)[NH+]=N[C@H]2c2ccc(Cl)cc2)c(OC)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC([C@@H]1CC[C@@H](CCC1)[NH+](CC(=O)[O-])CC=C)(C)C ### Response: C=CC[NH+](CC(=O)[O-])[C@@H]1CCC[C@H](C(C)(C)C)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)c1cccc(S(=O)(=O)N(C)Cc2c(C)nn(-c3ccccc3)c2C)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC[C@H]1CCC[NH+](Cc2cc(C)n(Cc3ccco3)c2C)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a carboxyl group? COCC[C@@H](C)C(=O)N(C)[C@H](C)c1ccc(-n2cncn2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC[NH+](CC)CC Fragment 2: [1*]C(=O)NCC[4*] ### Response: CC[NH+](CC)CCNC(=O)N1CCC[C@@H](OC)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=O)Nc1ccccc1)C(=O)N[C@H](C)c1ccc(OC(F)F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1ccccc1NC(=O)NCc1c(-n2cccc2)sc2c1CCCC2 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1cc(C(=O)N[C@@H]2CCCC[C@@H]2C[NH+](C)C)n(C)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. COc1cc(/C(=C/C(O[C@H]2CS(CC2)(=O)=O)=O)C)ccc1 ### Response: COc1cccc(/C(C)=C/C(=O)O[C@@H]2CCS(=O)(=O)C2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[4*] Fragment 2: [1*]C(=O)CCN[5*] ### Response: C[C@@H]1C[C@@H]1NC(=O)CCNC(=O)NC12CC3CC(CC(C3)C1)C2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1CCC[C@@H]1[15*] Fragment 2: [1*]C(=O)CC[4*] ### Response: CC(C)CC[C@H]1CCC[C@H]1NC(=O)NCCC(=O)N(C)C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1Cc2ccccc2[C@@H]1NC(=O)c1ccc2c(c1)C(=O)NC2=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](N[C@H](CO)c1cnn(C)c1)c1cccc(F)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)cccc1NC(=O)[C@H](NS(=O)(=O)c1cc2C[C@@H](C)N(C(C)=O)c2cc1)C(C)C ### Response: CC(=O)N1c2ccc(S(=O)(=O)N[C@@H](C(=O)Nc3cccc(C)c3)C(C)C)cc2C[C@H]1C
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(CN(C(=O)OC(C)(C)C)C)N1CCCC[C@@H]1C(NC)=O ### Response: CNC(=O)[C@H]1CCCCN1C(=O)CN(C)C(=O)OC(C)(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(Cc2sc(CC(C)C)nc2)CCN(c2c3c(ncn2)ccs3)CC1 ### Response: CC(C)Cc1ncc(CN2CCN(c3ncnc4ccsc34)CC2)s1
functional_group
### Instruction: Does the molecule contain a ketone group? CCC(=O)Nc1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@H](c1ccc(O)cc1O)N2 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[S@@](=O)c1ccc(CNC(=O)N[C@@H]2CCCC[C@@H]2OC2CCCC2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)F)COc1cccc(c1)[C@@H](C(=O)[O-])[NH3+] ### Response: [NH3+][C@H](C(=O)[O-])c1cccc(OCc2ccc(F)cc2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1[16*] Fragment 2: [1*]C(=O)NCC[4*] ### Response: C[NH+]1CCN(c2ccccc2NC(=O)NCCN2CCOCC2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccccc1NC(=O)C[C@@H]1CSc2nc3c(cnn3-c3ccc(C)cc3C)c(=O)n21 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cc1noc(C)c1CC(=O)Nc1ccc(S(=O)(=O)C(F)F)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#CCCNC(=O)COc1ccc(C(=O)[O-])nc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(/C=C2\SC(=O)N(c3cccc(O)c3)C2=O)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? CCC(=O)NCCOc1ccc2nnc(-c3ccc(F)cc3)n2n1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(F)c(N[C@H](C[NH3+])c2cccc(C)c2C)c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c2sccc2n2c(nnc2CSc2cccc(c2)F)n1C)=O ### Response: Cn1c(=O)c2sccc2n2c(CSc3cccc(F)c3)nnc12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(Cl)ccc1OC[C@H](O)CN1CCN(c2cccc(Cl)c2)CC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)c2c(c1)[C@@H]([NH2+]C[C@H]1CCN(S(C)(=O)=O)C1)CCO2 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(CSc2nnc(N3CCOCC3)n2C[C@@H]2CCCO2)no1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? COCc1ccccc1NC(=O)NCCn1c(C2CC2)n[nH]c1=S ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC#N Fragment 2: [1*]C(=O)c1ccccc1S[11*] ### Response: N#CCSc1ccccc1C(=O)Nc1ccc(F)c(Cl)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[C@@H]([15*])[C@H]1C Fragment 2: [1*]C(=O)C1CC1 ### Response: C[C@@H]1[C@H](C(=O)[O-])CCN1C(=O)C1CC1
functional_group
### Instruction: Does the molecule contain a amine group? COc1ccc(S(=O)(=O)N2CC[NH+]([C@@H](C)CCc3ccccc3)CC2)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=[N+]([O-])c1cnc(NCCc2ccc(F)cc2)c(Br)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1nnc([14*])s1 Fragment 2: [5*]Nc1nnc(C[8*])s1 ### Response: Cn1cnc(CNC(=O)Nc2nnc(Cc3cccc(F)c3)s2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccccc1 Fragment 2: [5*][NH+]1C[C@H](CO)CC[C@@H]1C ### Response: C[C@H]1CC[C@@H](CO)C[NH+]1Cc1ccn(Cc2ccccc2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CSC1[NH+]=c2ccccc2=[NH+]1)N[C@H]1Nc2ccc([N+](=O)[O-])cc2S1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(nc(C)cc1C(N(Cc1ccccc1C)Cc1cccnc1)=O)cccc2 ### Response: Cc1cc(C(=O)N(Cc2cccnc2)Cc2ccccc2C)c2ccccc2n1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1NC(=O)C(=O)N[C@@H]1CC[C@H](C1)SC)SC(F)F ### Response: CS[C@@H]1CC[C@@H](NC(=O)C(=O)Nc2ccc(SC(F)F)cc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1cccc2n1nc(n2)NC1CC[NH+](C)CC1 ### Response: Cc1cccc2nc(NC3CC[NH+](C)CC3)nn12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@H](C)NC(=O)c1ccc2oc(C(C)C)nc2c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. Nc1n(C2CCCCC2)nc(C(C)(C)C)c1[N+]([O-])=O ### Response: CC(C)(C)c1nn(C2CCCCC2)c(N)c1[N+](=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCC[C@]1(C(=O)[O-])c1ccc2c(c1)OCO2 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc([C@H](NC(=O)[C@H]2CCO[C@@H]2C)c2ccccc2F)no1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(c1c[nH]c2ccc(F)cc12)N(CC1CC1)CC(F)(F)F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C([1*])=O Fragment 2: [5*]N[C@H](C)CC ### Response: CC[C@@H](C)NC(=O)C(=O)NCCOC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCCCO[3*] Fragment 2: [3*]Oc1cccc(C)c1 ### Response: Cc1cccc(OCCCCC(=O)N2CCC[NH+](C(C)C)CC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(S(=O)(=O)CC(=O)N[C@H](C)C(C)C)[n-]c1Cc1ccccc1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C2=NO[C@H]3[C@H]4C[C@@H]([C@@H]23)[C@@H]2C(=O)N(Cc3cccnc3)C(=O)[C@H]42)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1ccc(/C=C2\SC(=S)N(CCC(=O)N3CC[C@@H](c4ccccc4)C3)C2=O)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Cl)c(c([C@@H]2Nc3c(cccc3[C@H]3C=CC[C@H]32)C(NC(C)(C)C)=O)cc1)Cl ### Response: CC(C)(C)NC(=O)c1cccc2c1N[C@@H](c1cccc(Cl)c1Cl)[C@@H]1CC=C[C@H]21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1sc(NC(=O)Cc2csc(C(C)C)n2)nc1C1CC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)c1cc(C(=O)NC[C@@H]2Cc3cccc(-c4ccncc4)c3O2)[nH]n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. S(N1C[C@@H](C(Nc2c(C)cccc2C)=O)CCC1)(Cc1c(C)cccc1)(=O)=O ### Response: Cc1ccccc1CS(=O)(=O)N1CCC[C@H](C(=O)Nc2c(C)cccc2C)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)c1nc([C@H]2CCCN2c2ncc(C#N)cc2Cl)no1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(OC)c(OC)cc(c1[C@@H](C)NC(Nc1nccs1)=O)C ### Response: COc1cc(C)c([C@@H](C)NC(=O)Nc2nccs2)cc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(NC)c1ccc(cc1)NC(=O)COc1ccc(cc1)C(C)C ### Response: CNC(=O)c1ccc(NC(=O)COc2ccc(C(C)C)cc2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](NC(=O)c1ccc(C=O)cc1)c1noc(Cc2ccccc2)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC1(C)C[C@@](O)(CC[C@@H]2CCCO2)C(C)(C)O1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@H](CS)CN1C[C@H](C)O[C@@H](C)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [S@@](C)(=O)c1ccc(cc1)C[NH2+]CCC1CCCC1 ### Response: C[S@@](=O)c1ccc(C[NH2+]CCC2CCCC2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)(C)NC(=O)/C=C/c1cc(c(c(OC)c1)OCC)Cl ### Response: CCOc1c(Cl)cc(/C=C/C(=O)NC(C)(C)C)cc1OC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)NCC(=O)N[C@H](c1ccccc1)c1ccc(F)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitrile group? N#Cc1ccc(NC(=O)CN2C(=O)[C@@H]3CCCC[C@H]3C2=O)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc2c(C)cccc2s1 Fragment 2: [1*]C(=O)c1cc(F)c(F)cc1Cl ### Response: Cc1cccc2sc(NC(=O)c3cc(F)c(F)cc3Cl)nc12
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1ccccc1-n1ncc([C@@H](C)NC(=O)c2cc(C(C)C)nc(N)n2)c1C ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1cccc(-c2cnco2)c1)[C@@H]1COc2ccccc2O1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(C)(C)C#C Fragment 2: [4*]C(C)(C)C#C ### Response: C#CC(C)(C)NC[C@H]1CN(C)CCO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1C Fragment 2: [5*]Nc1ccc2[nH]ncc2c1 ### Response: Cc1ccccc1CNc1ccc2[nH]ncc2c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCN1C(N)=[NH+]C[C@@]12CCC[NH+](C(C)C)CC2 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNC(=O)c1cccc(NC(=O)NNc2ccc(Cl)nn2)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc2c(c1C)[C@@H]([NH2+][C@H](CO)c1cc(F)c(F)c(F)c1)CCO2 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)NC[C@@H](c1cccs1)[NH+]1CCC(C)CC1)Oc1ccc(cc1)C#N ### Response: CC1CC[NH+]([C@@H](CNC(=O)COc2ccc(C#N)cc2)c2cccs2)CC1