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Since its first description in 1841, numerous variations and treatments of Polands syndrome congenital deficiency of the pectoralis major muscle associated with brachysyndactyly have been reported.
{ "m": "Establishing the importance of the topic for the discipline: time frame given", "s": "418.27" }
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W83113632
Importance
None of the reports, however, involved female Chinese patients.
{ "m": "Stating a negative result", "s": "479.26" }
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W83113632
Result
A retrospective study of 24 female patients was conducted to guide the selection of methods of surgical reconstruction.
{ "m": "Describing the research design and the methods used", "s": "386.3" }
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W83113632
Method
The patients were divided into three groups according to the degree of thoracic tissue development.
{ "m": "Describing the characteristics of the participants", "s": "414.88" }
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W83113632
Method
Type I mild Limited tissue loss which can be treated with simple filling with autologous fat andor an artificial breast implant.
{ "m": "Indicating criteria for selection or inclusion in the study", "s": "560.69" }
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W83113632
Method
Type II moderate Moderate thoracic tissue hypoplasia where the breast parenchyma can still offer adequate implant coverage.
{ "m": "Indicating criteria for selection or inclusion in the study", "s": "553.07" }
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W83113632
Method
Mammoplasty using a latissimus dorsi muscular flap with an implant was performed in this group.
{ "m": "Indicating criteria for selection or inclusion in the study", "s": "415.82" }
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W83113632
Method
The flap was used to fill the infraclavicular hollow, and the implant was placed in the dualplane pocket.
{ "m": "Describing the process: typical verbs in the passive form", "s": "500.76" }
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W83113632
Method
Type III severe Severe thoracic tissue hypoplasia, without sufficient parenchyma to offer implant coverage.
{ "m": "Detailing specific limitations", "s": "578.44" }
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W83113632
Limitations
A latissimus dorsi muscular flap was used to form a total submuscular pocket in which an implant was placed.
{ "m": "Describing the process: using + instrument", "s": "459.43" }
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W83113632
Method
The numbers of Type I, II, and III patients were 15, 3, and 6, respectively.
{ "m": "Describing the characteristics of the participants", "s": "479.53" }
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W83113632
Method
All of the flaps and injected fat demonstrated good survival.
{ "m": "Stating a positive result", "s": "390.75" }
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W83113632
Result
Satisfactory cosmetic results were exhibited during the followup period of 1 to 9 years.
{ "m": "Describing the process: typical verbs in the passive form", "s": "443.82" }
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W83113632
Method
Although this group of patients showed varied conditions, they can be roughly divided into three types according to the degree of thoracic tissue development.
{ "m": "Acknowledging limitation(s) whilst stating a finding or contribution", "s": "392.16" }
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W83113632
Limitations
In our experience, this classification is simple and useful in choosing the breast reconstruction options.
{ "m": "Referring back to the research aims or procedures", "s": "616.33" }
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W83113632
Aims
Expert SystemsVolume 12, Issue 4 p. 355355 The resurgence of the AI field IJCAI95, Montreal, 2025 August 1995 David Blanchard, David Blanchard PO Box 159, Kent, OH 44240, USA Email 71224.2346compuserve.com WWW httpwww.lionhrtpub.comSearch for more papers by this author David Blanchard, David Blanchard PO Box 159, Kent,...
{ "m": "Summarising the studies reviewed", "s": "471.63" }
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W2129793670
Method
I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a fulltext version of this article with your friends and colleagues.
{ "m": "Referring to the literature to justify a method or approach ", "s": "596.55" }
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W2129793670
Purpose
Learn more.
{ "m": "Suggesting implications for what is already known", "s": "606.42" }
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W2129793670
Implications
Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume12, Issue4November 1995Pages 355355 RelatedInformation
{ "m": "Explaining the provenance of articles for review", "s": "445.05" }
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W2129793670
Method
Objective Nectin and nectinlike molecules Necls are cell molecules that are involved in cellcell adhesion and other vital cellular processes.
{ "m": "Providing background information: reference to the purpose of the study", "s": "474.86" }
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W4200255029
Background
This study aimed to determine the expression and prognostic value of nectin and Necls in low grade glioma LGG.
{ "m": "Stating the focus, aim, or argument of a short paper", "s": "380.05" }
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W4200255029
Hypothesis
Materials and Methods Differentially expressed nectin and Necls in LGG samples and the relationship of nectin family and necls expression with diagnosis, clinicopathological parameters and survival were explored using The Cancer Genome Atlas TCGA, the Chinese Glioma Genome Atlas CGGA, and REMBRANDT databases.
{ "m": "Describing previously used methods", "s": "357.79" }
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W4200255029
Method
Univariate and multivariate Cox analysis model were performed to construct the prognosisrelated gene signature.
{ "m": "Describing questionnaire design", "s": "459.98" }
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W4200255029
Method
KaplanMeier curves and timedependent receiver operating characteristic ROC curves and multivariate Cox regression analysis, were utilized to evaluate the prognostic capacity of the fourgene signature.
{ "m": "Describing the process: statistical procedures", "s": "411.13" }
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W4200255029
Method
Gene ontology GOenrichment analysis and Gene Set Enrichment Analyses GSEA were performed to further understand the underlying molecular mechanisms.
{ "m": "Referring back to the research aims or procedures", "s": "441.84" }
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W4200255029
Aims
Tumor immune estimation resource TIMER was used to explore the relationship between the fourgene signature and tumor immune infiltration.
{ "m": "Describing the process: typical verbs in the passive form", "s": "470.65" }
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W4200255029
Method
Results Several nectin and Necls were differentially expressed in LGG.
{ "m": "Reporting positive and negative reactions", "s": "478.04" }
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W4200255029
Result
KaplanMeier survival analyses and Univariate Cox regression showed patients with high expression of NECTIN2 and PVR and low expression of CADM2 and NECTIN1 had worse prognosis among TCGA, CGGA and REMBRANDT database.
{ "m": "Describing the process: statistical procedures", "s": "499.78" }
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W4200255029
Method
Then, a novel fourgene signature was built for LGG prognosis prediction.
{ "m": "Setting out the research questions or hypotheses", "s": "524.94" }
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W4200255029
Aims
Roc curves, KM survival analyses and multivariate COX regression indicated the new signature was an independent prognostic indicator for overall survival.
{ "m": "Reporting positive and negative reactions", "s": "458.48" }
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W4200255029
Result
Finally, GSEA and GO enrichment analyses revealed immunerelated pathways participate in the molecular mechanisms.
{ "m": "Summarising the main research findings", "s": "505.45" }
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W4200255029
Result
The risk score had a strong negative correlation with tumor purity and data of TIMER showed different immune cell proportions macrophage and myeloid dendritic cell between high and lowrisk groups.
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W4200255029
Result
Additionally, signature scores were positively related to multiple immunerelated biomarkersIL 2,IL8 and IFNγ.
{ "m": "Highlighting significant data in a table or chart", "s": "591.61" }
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W4200255029
Result
Conclusion Our results offer an extensive analysis of nectin and Necls levels and a fourgenemodel for prognostic prediction in LGG, providing insights for further investigation of CADM2, NECTIN12 and PVR as potential clinical and immune targets in LGG.
{ "m": "Explaining the significance of the findings or contribution of the study", "s": "336.35" }
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W4200255029
Importance
Analysis of the novel Die Asthetik des Widerstands The Aesthetics of Resistance by GermanSwedish author Peter Weiss 19161982.
{ "m": "Describing the research design and the methods used", "s": "446.03" }
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W1914714158
Method
The main question in the analysis is how the novel depicts the the literary work, since the narrator of the novel is a writer.
{ "m": "Indicating criteria for selection or inclusion in the study", "s": "553.73" }
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W1914714158
Method
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonvolatile acids of passion fruit juiceHarvey T. Chan Jr., Thomas S. K. Chang, and Eduardo ChenchinCite this J. Agric.
{ "m": "Some ways of introducing quotations", "s": "585.52" }
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W2019917929
Result
Food Chem.
{ "m": "Describing the characteristics of the participants", "s": "617.14" }
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W2019917929
Method
1972, 20, 1, 110112Publication Date PrintJanuary 1, 1972Publication History Published online1 May 2002Published inissue 1 January 1972httpspubs.acs.orgdoi10.1021jf60179a012httpsdoi.org10.1021jf60179a012researcharticleACS PublicationsRequest reuse permissionsArticle Views219AltmetricCitations23LEARN ABOUT THESE METRICSA...
{ "m": "Explaining the provenance of articles for review", "s": "446.24" }
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W2019917929
Method
These metrics are regularly updated to reflect usage leading up to the last few days.
{ "m": "Describing the process: typical verbs in the passive form", "s": "330.95" }
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W2019917929
Method
Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
{ "m": "Explaining the provenance of articles for review", "s": "500.37" }
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W2019917929
Method
Find more information about Crossref citation counts.
{ "m": "Providing background information: reference to the literature", "s": "592.94" }
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W2019917929
Background
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online.
{ "m": "Stating the purpose of the thesis, dissertation, or research article (note use of present tense)", "s": "443.52" }
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W2019917929
Purpose
Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article.
{ "m": "Synthesising sources: supporting evidence or ideas", "s": "492.1" }
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W2019917929
Result
Find more information on the Altmetric Attention Score and how the score is calculated.
{ "m": "Providing background information: reference to the purpose of the study", "s": "556.1" }
[ 0.6480333209037781, 0.8281055688858032, -3.509704351425171, -0.3838290572166443, 1.3131358623504639, 0.6003532409667969, 1.7514855861663818, -0.278552383184433, -0.283307820558548, 0.566392719745636, -0.0009395082597620785, 1.3012281656265259, 2.4981372356414795, 0.17596061527729034, 0.7...
[ 0.49099698662757874, -0.0043648118153214455, -1.5295219421386719, 0.030155645683407784, 1.3592758178710938, -0.06820623576641083, 0.8478637337684631, -0.789479672908783, -0.18132369220256805, -1.6502232551574707, 0.5914692878723145, 1.3247663974761963, 1.0262240171432495, -0.04727914184331...
W2019917929
Background
Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet eAlertsclose Get eAlerts
{ "m": "Synthesising sources: contrasting evidence or ideas", "s": "517.96" }
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[ 0.3921673595905304, 0.07737910002470016, -1.4352155923843384, -0.5514642596244812, 2.1580653190612793, 0.8282127976417542, -0.8497844338417053, 0.29464003443717957, 0.030068183317780495, -0.18308907747268677, 0.791553795337677, 0.040642816573381424, 0.5848815441131592, 2.6250250339508057, ...
W2019917929
Uncertainty
In this paper, we give sufficient conditions for the essential selfadjointness of second order elliptic operators.
{ "m": "Referring back to the purpose of the paper or study", "s": "534.53" }
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[ 1.1896132230758667, 1.03553307056427, -1.8726387023925781, -0.3871133327484131, 0.48720672726631165, -1.4525467157363892, -2.03999400138855, -1.0652185678482056, -0.5579152703285217, -0.8029164671897888, 1.3434096574783325, 1.2056602239608765, 0.32014647126197815, 0.6882772445678711, 1.4...
W1558204805
Purpose
It turns out that these conditions coincide with those for the Schrödinger operator on a manifold whose metric essentially depends on the principal coefficients of a given operator.
{ "m": "Suggesting general hypotheses", "s": "495.15" }
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[ 0.9267382621765137, 0.7012555599212646, -0.28589725494384766, -0.22242510318756104, 0.1229337826371193, 0.3957783281803131, -1.6369675397872925, 0.25250381231307983, 0.39321112632751465, 0.17242646217346191, 0.07048024982213974, 0.12983740866184235, 0.5357500910758972, 0.9739608764648438, ...
W1558204805
Hypothesis
We conducted a contact investigation in a psychiatric hospital to evaluate the nosocomial transmission of tuberculosis TB.
{ "m": "Indicating the methodology for the current research", "s": "413.86" }
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[ 0.981802225112915, 0.05391121283173561, -1.1307029724121094, -0.22862371802330017, 0.5677791833877563, -2.4708430767059326, 0.4084259569644928, -1.1738067865371704, 0.33671513199806213, 1.3858174085617065, 0.9931116700172424, -1.0757009983062744, 2.3535048961639404, -0.3235900402069092, ...
W1535458454
Method
Contacts included hospital healthcare workers HCWs and inpatients who had been exposed to an index case of pulmonary TB.
{ "m": "Describing the characteristics of the participants", "s": "481.95" }
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[ -0.9243452548980713, -0.03652903065085411, -1.8947632312774658, -1.1477861404418945, 0.7601274847984314, -0.4665917158126831, -0.8815044164657593, -1.4512457847595215, 0.701407790184021, 0.7915835380554199, -1.8415805101394653, 0.3193439543247223, 1.0423941612243652, 0.7783510684967041, ...
W1535458454
Method
Contacts were evaluated for Mycobacterium tuberculosis infection with standard screening methods as well as the QuantiFERONTB Gold QFTG test.
{ "m": "Describing the process: using + instrument", "s": "453.14" }
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[ 1.2351077795028687, -2.19478178024292, -1.8727080821990967, 0.024818938225507736, 2.225703239440918, -0.5916649103164673, 1.8548846244812012, -0.37088334560394287, 0.5343470573425293, 0.39386406540870667, -0.6128445863723755, -0.31607455015182495, 1.1390291452407837, 0.5330187678337097, ...
W1535458454
Method
A tuberculin skin test TST was administered to 3 individuals who were under 30 years old, and all tests were negative.
{ "m": "Describing the process: typical verbs in the passive form", "s": "453.6" }
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[ 1.8275614976882935, -0.7779861688613892, -1.4180657863616943, 0.3413856029510498, 1.8653898239135742, 0.6296572089195251, 1.3109338283538818, -1.30795156955719, -0.4886684715747833, -0.4632934033870697, -1.7162272930145264, 0.8782803416252136, 1.0611845254898071, 0.13140009343624115, -0....
W1535458454
Method
Chest Xray examination was performed for all 46 contacts 9 HCWs and 37 patients.
{ "m": "Describing the process: typical verbs in the passive form", "s": "497.22" }
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[ 0.7873575091362, -1.1695393323898315, -2.8178486824035645, -0.10104657709598541, 1.3160895109176636, -0.9464097023010254, 0.7893497943878174, -0.8901160359382629, 0.19378893077373505, -0.6713832020759583, -0.8742793202400208, 1.098877191543579, -0.017998352646827698, 0.5522477030754089, ...
W1535458454
Method
Five had abnormal chest Xray results that were not compatible with TB, and 41 had normal chest Xrays.
{ "m": "Surveys and interviews: Reporting response rates", "s": "467.15" }
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[ 1.278326392173767, -1.604447364807129, -1.8016040325164795, 0.017508529126644135, 1.6419191360473633, -0.901017427444458, 1.0422394275665283, -1.7436997890472412, -0.3833185136318207, -1.213456630706787, -1.3133033514022827, 1.1017155647277832, 0.06756994128227234, 0.2493864893913269, -0...
W1535458454
Method
As regards the QFTG test, 23 of the 46 50 contacts, 1 HCW an 81yearold male and 22 patients, were positive.
{ "m": "Stating a positive result", "s": "442.63" }
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[ 0.9108226895332336, -0.888373613357544, -2.2212557792663574, -0.3721695840358734, 1.7194600105285645, -1.296203851699829, -0.6002098917961121, -1.6148271560668945, 0.3827161490917206, -1.6428238153457642, -0.9181678891181946, 1.1362676620483398, 0.1512298583984375, 0.32482028007507324, -...
W1535458454
Result
The results suggest that there was significant nosocomial transmission of TB infection among inpatients in this psychiatric hospital.
{ "m": "Suggesting general hypotheses", "s": "536.57" }
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[ 1.8811157941818237, 0.7800328731536865, -0.7095305919647217, -0.15450385212898254, 1.1284105777740479, -0.11836636066436768, -0.4289237856864929, -0.0881243571639061, 0.6964672803878784, -1.090849757194519, 0.7923265099525452, 1.1484870910644531, 0.9121993780136108, 0.483052134513855, 0....
W1535458454
Hypothesis
Moreover, these findings indicate that the use of chest Xray and TST, i.e., conventional methods of detection will leave TB infection undetected in many individuals.
{ "m": "Noting implications of the findings", "s": "260.04" }
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[ 0.7164484262466431, 1.4096912145614624, 1.955629825592041, 0.27989688515663147, 0.6177766919136047, -0.011154341511428356, -1.3256325721740723, 1.2107282876968384, 1.1131582260131836, -0.6444078683853149, -0.14705616235733032, 0.23347124457359314, 0.8717374205589294, -0.6215348839759827, ...
W1535458454
Implications
Thus, introduction of screening for TB infection using the QFTG test in longterm care facilities such as psychiatric hospitals may enable the detection and treatment of individuals with latent TB in whom the infection would otherwise be missed by other conventional screening methods.
{ "m": "Noting implications of the findings", "s": "404.13" }
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[ 0.014361823908984661, 2.3788187503814697, 1.5633351802825928, -0.5293452739715576, 1.149225115776062, -0.21568062901496887, -0.940457284450531, 1.1440919637680054, 1.7394522428512573, -0.7254176735877991, 0.6890997290611267, -0.44824856519699097, 0.5725072622299194, 1.4396570920944214, 1...
W1535458454
Implications
While smartphones and mobile apps have been an essential part of our lives, privacy is a serious concern.
{ "m": "Establising the importance of the topic as a problem to be addressed", "s": "487.19" }
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W1437814062
Importance
Previous mobile privacy related research efforts have largely focused on predefined known sources managed by smartphones.
{ "m": "Previous research: What has been established or proposed", "s": "352.25" }
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W1437814062
Background
Sensitive user inputs through UI User Interface, another information source that may contain a lot of sensitive information, have been mostly neglected.
{ "m": "Establising the importance of the topic as a problem to be addressed", "s": "503.5" }
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[ 0.6948418617248535, 0.14704516530036926, -2.2298099994659424, -0.006659757345914841, 2.065439224243164, 1.4199705123901367, 0.6276182532310486, 0.28002986311912537, 1.5790153741836548, -0.6038569808006287, 0.3051612079143524, 0.23810838162899017, 0.5638450384140015, 0.5063426494598389, 1...
W1437814062
Importance
In this paper, we examine the possibility of scalably detecting sensitive user inputs from mobile apps.
{ "m": "Stating the aims of the current research (note frequent use of past tense)", "s": "368.06" }
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W1437814062
Hypothesis
In particular, we design and implement SUPOR, a novel static analysis tool that automatically examines the UIs to identify sensitive user inputs containing critical user data, such as user credentials, finance, and medical data.
{ "m": "Describing the research design and the methods used", "s": "435.78" }
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[ -0.5152537822723389, -0.4130171537399292, -1.0300036668777466, -1.1363238096237183, 0.39974936842918396, -3.17311692237854, -0.04770921543240547, -0.4475448727607727, -1.2694897651672363, -0.12589484453201294, 1.6199027299880981, -0.9842514395713806, 2.953470468521118, 0.6827584505081177, ...
W1437814062
Method
SUPOR enables existing privacy analysis approaches to be applied on sensitive user inputs as well.
{ "m": "Referring to previous work to establish what is already known", "s": "438.56" }
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W1437814062
Background
To demonstrate the usefulness of SUPOR, we build a system that detects privacy disclosures of sensitive user inputs by combining SUPOR with offtheshelf static taint analysis We apply the system to 16,000 popular Android apps, and conduct a measurement study on the privacy disclosures.
{ "m": "Describing the process: infinitive of purpose", "s": "403.03" }
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[ -0.13226968050003052, 1.5564534664154053, -0.5934683084487915, -0.2530747652053833, 1.390683650970459, -2.5930652618408203, -0.17156213521957397, 0.08303476870059967, -0.08034449815750122, 0.5922773480415344, 0.2517743408679962, 0.020655816420912743, 1.6012316942214966, 1.0364898443222046,...
W1437814062
Method
SUPOR achieves an average precision of 97.3 and an average recall of 97.3 for sensitive user input identification.
{ "m": "Highlighting interesting or surprising results", "s": "420.4" }
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[ 1.5194597244262695, 1.4269689321517944, -2.987027883529663, 0.47958722710609436, 1.4809260368347168, -0.6523132920265198, 1.3373453617095947, 1.331195592880249, -0.05307073891162872, -1.0030598640441895, 0.5096270442008972, 0.7753032445907593, 1.2000764608383179, 0.6049132347106934, 0.43...
W1437814062
Result
SUPOR finds 355 apps with privacy disclosures and the false positive rate is 8.7.
{ "m": "Stating a positive result", "s": "509.37" }
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[ 1.3580420017242432, 0.08823291212320328, -3.336361885070801, -0.20420578122138977, 1.8762928247451782, -1.7333894968032837, 1.817336082458496, 0.8216096758842468, 0.3627578914165497, -0.30713289976119995, -0.002578162122517824, -0.3091539442539215, 1.7790398597717285, -0.46792712807655334,...
W1437814062
Result
We discover interesting cases related to national ID, usernamepassword, credit card and health information.
{ "m": "Highlighting interesting or surprising results", "s": "459.83" }
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[ 1.2599902153015137, 1.6705902814865112, -1.9089856147766113, -0.09529795497655869, 1.4333494901657104, -1.032247543334961, -0.19988439977169037, -1.9074660539627075, 1.0028882026672363, -2.2810487747192383, -0.02695084735751152, 0.2895432710647583, 0.932917594909668, 0.8756778836250305, ...
W1437814062
Result
The position, that the peculiarities of realization of social security norms are revealed more clearly when being considered as applied to their different types and firstly, to material and procedural norms, is substantiated in the present article.
{ "m": "Suggesting general hypotheses", "s": "428.61" }
[ 0.7413721084594727, 0.9707410931587219, -3.212188959121704, 0.1577311009168625, 0.7743691802024841, 0.37666916847229004, -0.2692898213863373, -0.5079594850540161, 0.6798076033592224, 0.539569616317749, -0.5458622574806213, -0.8076134324073792, 0.820700466632843, 0.8683808445930481, 0.626...
[ 1.610604166984558, 1.00290846824646, -0.9529742002487183, -0.4580574035644531, 1.3864332437515259, -0.7813056707382202, -1.155372142791748, 0.748212456703186, 1.2702645063400269, -0.2529735267162323, 0.7217633724212646, 0.43636053800582886, -1.5243163108825684, 0.9773929119110107, 0.8189...
W159768125
Hypothesis
Law enforcement is proved to be the principal form of realization of material norms in Social Security Law.
{ "m": "Restating a result or one of several results", "s": "517.15" }
[ 0.8966770172119141, 0.39661815762519836, -3.462338447570801, 0.46122196316719055, 0.7539675831794739, 0.45062366127967834, -0.1803199052810669, 0.32948800921440125, 0.6591042876243591, 0.6348275542259216, -0.31712988018989563, -0.8719284534454346, 1.1935712099075317, 0.2554490268230438, ...
[ 1.1392748355865479, 0.34118184447288513, -2.5662424564361572, 0.21699242293834686, 1.5864815711975098, -1.6639373302459717, -0.5046479105949402, -0.23902037739753723, 0.41975662112236023, -1.4680225849151611, -0.02300684154033661, 1.581736445426941, -0.8820136189460754, -0.0372106730937957...
W159768125
Result
The specificity of law enforcement activity in the sphere of social security is disclosed.
{ "m": "Suggesting general hypotheses", "s": "603.29" }
[ 0.7637574076652527, 0.8142362236976624, -3.257983922958374, 0.39719533920288086, 0.6711854934692383, -0.040001802146434784, 0.07122518122196198, -0.0362972766160965, 1.3966706991195679, 0.21976013481616974, -0.7003813982009888, 0.06972517818212509, 1.3437714576721191, 0.17749202251434326, ...
[ 1.4445385932922363, 0.6661636233329773, -2.0357916355133057, 0.8690142631530762, 1.405824065208435, -0.29745522141456604, -0.46197524666786194, -0.7137458920478821, 0.6810215711593628, -0.4384082853794098, 0.2870115339756012, 1.0720916986465454, -1.2692655324935913, 0.7307157516479492, 1...
W159768125
Hypothesis
Some peculiarities of realization of social security procedural norms are examined.
{ "m": "Describing the process: typical verbs in the passive form", "s": "532.27" }
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[ 1.6843498945236206, 0.11772918701171875, -2.1698195934295654, 0.16648444533348083, 1.0520070791244507, -1.0290354490280151, -0.04503970593214035, -1.2435908317565918, 1.0827391147613525, -0.31841495633125305, 0.1705867350101471, 0.7015901803970337, 0.9362989068031311, 1.919471025466919, ...
W159768125
Method
Rings of cohesin hold together sister chromatids.
{ "m": "Restating a result or one of several results", "s": "480.32" }
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W1969926758
Result
Armelle Lengronne, Frank Uhlmann Cancer Research UK, London, UK, Katsuhiko Shirahige Tokyo Institute of Technology, Yokohama, Japan, and colleagues now suggest that cohesin rings get pushed to their final resting places by transcription complexes.
{ "m": "Referring to another writer’s idea(s) or position", "s": "439.64" }
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[ -1.505206823348999, 0.30864453315734863, -2.1062378883361816, -0.14834243059158325, 1.3286406993865967, -0.7305395007133484, -1.685663104057312, -0.8407974243164062, 0.21478624641895294, 1.8328226804733276, 1.2310787439346313, 0.7729281783103943, -0.3517451286315918, 1.4281089305877686, ...
W1969926758
Background
Figure Cohesin binds more black between convergent genes but less gray in the middle of active genes.
{ "m": "Referring to data in a table or chart", "s": "527.49" }
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[ 0.3721960186958313, 0.9070928692817688, -2.208092451095581, -0.8565963506698608, 0.1517195701599121, -1.2994838953018188, 1.3727467060089111, -1.8483678102493286, -1.6328014135360718, -0.7920665144920349, -0.6449915766716003, 1.437934160232544, 1.444502830505371, 0.6958218216896057, 0.53...
W1969926758
Result
Cohesins are known to bind a heterochromatin protein at centromeres, but previous reports of cohesin localization on chromosome arms were incomplete.
{ "m": "Referring to previous work to establish what is already known", "s": "399.29" }
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[ 0.8732550740242004, -0.9803159236907959, -1.4219101667404175, -2.133350372314453, 0.39319100975990295, 1.5038845539093018, -0.5561671257019043, 0.8736751079559326, 0.4778600335121155, 0.09502610564231873, 1.8748376369476318, 0.0392344668507576, 0.2412617951631546, 0.19314239919185638, -0...
W1969926758
Background
The authors did a comprehensive survey of four budding yeast chromosomes and two fission yeast chromosomes using chromatin immunoprecipitation.
{ "m": "Describing the research design and the methods used", "s": "337.71" }
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[ -0.11648491024971008, 0.08106432855129242, -1.3469302654266357, -0.17138497531414032, -0.5960104465484619, -2.4111573696136475, 0.038911789655685425, -1.3309718370437622, -0.3177931606769562, 1.4160189628601074, -0.05136572942137718, -1.8394250869750977, 2.0596935749053955, -1.281589746475...
W1969926758
Method
In budding yeast, 91 of cohesin sites were between converging genes, and cohesins were bound to 84 of the 328 convergent intergene regions.
{ "m": "Surveys and interviews: Reporting response rates", "s": "541.46" }
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[ 0.25630050897598267, -0.30968913435935974, -2.02504563331604, -0.28525859117507935, 0.8815674781799316, -1.5166869163513184, 1.4240977764129639, -1.2475123405456543, -0.9265033602714539, -1.077546238899231, -1.1982500553131104, 0.48845791816711426, 0.6873847842216492, 0.530958354473114, ...
W1969926758
Method
Earl Glynn, Jennifer Gerton Stowers Institute, Kansas City, MO and colleagues gathered similar data for budding yeast.
{ "m": "Surveys and interviews: Reporting participants’ views", "s": "520.61" }
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W1969926758
Method
They suggest that transcription displaces cohesin from the DNA of active genes, and that the chromatin in convergent intergenic regions may be a stickier substrate for cohesin.
{ "m": "Suggesting general hypotheses", "s": "520.24" }
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W1969926758
Hypothesis
But Uhlmanns group favors the sliding model.
{ "m": "Suggesting general hypotheses", "s": "533.87" }
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W1969926758
Hypothesis
Looking earlier, they saw that cohesins initially load at sites defined by the loading protein Scc2.
{ "m": "Referring to previous work to establish what is already known", "s": "511.28" }
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W1969926758
Background
These sites are most often in highly transcribed regions, but soon after loading the cohesin moves toward the intergenic regions.
{ "m": "Describing the process: typical verbs in the passive form", "s": "528.41" }
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W1969926758
Method
This would get the cohesin away from the loading proteins, which may have an opening activity that can also promote unloading.
{ "m": "Suggesting general hypotheses", "s": "542.18" }
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W1969926758
Hypothesis
Cohesin that was seen in the middle of several dormant genes later moved downstream when the genes were turned on during either meiosis or heat shock.
{ "m": "Describing the process: sequence words", "s": "453.31" }
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W1969926758
Method
Passive pushing is conceivable, says Uhlmann, because proteins bound to RNA polymerase and its nascent transcript make the transcription machinery quite enormous.
{ "m": "Suggesting general hypotheses", "s": "502.15" }
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W1969926758
Hypothesis
Pushing would prevent transcripts from getting stuck in the rings.
{ "m": "Acknowledging limitation(s) whilst stating a finding or contribution", "s": "608.25" }
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W1969926758
Limitations
The replication machinery may, however, slip through the cohesin rings, which are loaded well before DNA replication starts.
{ "m": "Indicating methodological problems or limitations", "s": "416.1" }
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W1969926758
Limitations
References Lengronne, A., et al. 2004.
{ "m": "Referring to secondary sources", "s": "559.53" }
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W1969926758
Background
Nature.
{ "m": "Describing the characteristics of the participants", "s": "671.76" }
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W1969926758
Method
10.1038nature02742.
{ "m": "Describing the characteristics of the participants", "s": "565.22" }
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W1969926758
Method
PMC free article PubMed Glynn, E.F., et al. 2004.
{ "m": "Referring to secondary sources", "s": "564.72" }
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W1969926758
Background
PLoS Biol.
{ "m": "Restating a result or one of several results", "s": "579.7" }
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W1969926758
Result
10.1371journal.pbio.0020259.
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W1969926758
Result
PMC free article PubMed
{ "m": "Stating the purpose of the thesis, dissertation, or research article (note use of present tense)", "s": "538.77" }
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W1969926758
Purpose
Summary Tolerance of various degrees of primary subcutaneous grafts of mouse tumors was conferred on rats pretreated with suspensions of lyophilized mouse tumors of the same tumor strains.
{ "m": "Referring back to the research aims or procedures", "s": "454.49" }
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W1536591877
Aims
Inoculations of transplantable mouse tumors into rats resulted in tumors in 84 per cent of the treated rats.
{ "m": "Surveys and interviews: Reporting response rates", "s": "423.96" }
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W1536591877
Method
These tumors were all of considerable size up to 6 5 cm..
{ "m": "Describing the characteristics of the participants", "s": "279.9" }
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W1536591877
Method
Some of them regressed at intervals up to 42 days, while some persisted to the death of the animal.
{ "m": "Reporting positive and negative reactions", "s": "374.03" }
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W1536591877
Result
Untreated control rats of the same age and strain were resistant to grafts of the same mouse tumors.
{ "m": "Describing the process: typical verbs in the passive form", "s": "440.82" }
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W1536591877
Method