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The use of glass ionomer cement for mastoid obliteration, reconstruction of the external ear canal, closure of the translabyrinthine approach for acoustic neuroma and fixation of a cochlear implant in the temporal bone is described. Preliminary results are encouraging, although some epithelialisation defects may occur ... |
The "bottom-up" model of evidence-based practice (EBP) emphasizes the principles of integrating best research evidence with clinical expertise and patient values. It is derived from multidisciplinary sources, including clinical medicine, epidemiology, and adult learning theory, and has been applied to many medical disc... |
Ankle diastasis without associated fracture occurs in a latent form in which the diastasis is detected only by stress radiographs, and in a frank form with the diastasis visible on routine, unstressed radiographs. Whereas latent ankle diastasis requires no reduction and can be treated by cast immobilization, frank dias... |
Alopecia areata (AA) is a hair loss disease marked by a focal inflammatory infiltrate of dystrophic anagen stage hair follicles by CD4+ and CD8+ lymphocytes. Although AA is thought to be an autoimmune disorder, definitive proof is lacking. Moreover, characterization of the primary pathogenic mechanisms by which hair lo... |
In line with the progress of artificial intelligence, electronic negotiation theory has developed a great variety of promising negotiation models. These models have been evaluated in several ways. Besides formal evaluation, which could prove a lot of optimality properties, some researchers have already examined the use... |
Infection with specific types of HPV has emerged as necessary but not sufficient factor in the neoplastic transformation of anogenital condylomas. Some viruses (HIV, Herpes viridae: HSV, CMV, EBV) might act as cofactors in the neoplastic changes and cancer. To study the prevalence of these viral pathogens in anogenital... |
A robust adaptive controller is presented for the control system of user-satellite antenna acquisition and tracking TDRS (tracking and data relay satellite), which faces with the uncertainties of un-modeled dynamics and unknown bounded disturbance and the control input constraint. The stability is proved by using Lyapu... |
This book is a collection of sixteen papers delivered at a conference held in New York University to commemorate the centennial of the Fourteenth Amendment to the United States Constitution. The list of contributors is impressive, but, as in most works of this type, the essays vary in length, quality and indeed in rele... |
This paper examines whether a country's corporate transparency environment, which includes the quality of accounting information, contributes to efficient resource allocation. Based on a cross-country study of 37 manufacturing industries in 37 countries, we provide three pieces of related evidence. First, we find the c... |
Peripheral resistance was examined in the microcirculation of the rat cremaster muscle using a network-conserved parameter, power dissipation. Previous studies of peripheral resistance used network-sensitive parameters, and their interpretation is limited by tacit assumptions about the structure of the peripheral vascu... |
Pediatric parenteral nutrition-associated liver disease (PNALD) is typically defined as a decrease in bile flow that is independent of a mechanical obstruction and of any other underlying liver disease. It is most often seen in pediatric patients receiving parenteral nutrition support. Up to 50% to 66% of children rece... |
AIMS |
The main aim of this study is to better understand the self-aggregation mechanism of amyloid-like elastin-derived fibers in order to design and produce new powerful drugs that will inhibit the onset of 'amyloidosis'. |
MATERIALS & METHODS |
Atomic force microscopy (AFM), Congo Red birefringence assay and Thioflavin T fluorescence measurements were used to demonstrate the amyloid-like behavior of some fragments of elastin protein (exon 30 [EX30] and exon 28 [EX28]). Turbidimetry on apparent absorbance technique was used to investigate the effect either of ... |
RESULTS & DISCUSSION |
We used Congo Red birefringence assay, Thioflavin T fluorescence measurements and AFM measurements that are used commonly to demonstrate the formation of amyloids. The elastin fibrillogenesis is amyloid-like. Then, the elastin amyloidogenesis is inhibited by particular pentapeptides. |
CONCLUSIONS |
We have reported herein that the fibrillogenesis of elastin-derived EX28 and EX30 polypeptides is facilitated significantly by the effect of sodium taurocholate bile salt and is inhibited by a classical inhibitor of Abeta-amyloid peptide, such as KLVFF, as well as by novel inhibitors, designed by us on the basis of som... |
Development of a simple, rapid, and accurate methodology for clenbuterol residue extraction in bovine hair and retina by diphasic dialysis was evaluated. After bovine hair and retina samples digestion, diphasic dyalisis was used as an extraction procedure using four organic solvents (dichloromethane, n-hexane, ethyl ac... |
Purpose: Fluoropyrimidines, oxaliplatin, irinotecan and targeted therapies represent the standard treatment of metastatic colorectal cancer. After failure of all these treatments, few options are available. In such chemorefractory patients the effect of triplet chemotherapy with bevacizumab (FOLFIRINOX bevacizumab) has... |
Our previous attempts to predict the toxicities of 24 metal ions for a given species, using physicochemical parameters associated with the ions, are summarized. In our current attempt we have chosen indicators of toxicity for biological systems of increasing levels of complexity--starting with individual biological mol... |
This paper deals with a computational model of artificial emotion for "Active Human Interface" that generates emotion and facial expressions from the emotional evaluation state of external stimuli given to the model using the harmony theory, neural network and genetic algorithm. The harmony theory, a type of Boltzmann ... |
This descriptive research paper reports on 52 geriatric defendants accused of criminal offenses and referred for forensic psychiatric evaluation. It addresses demographic and clinical variables in that population. The authors hope that the data will assist in planning for forensic and therapeutic services for geriatric... |
Cu bond wires in microelectronics have great potential but also provides several challenges. The acceleration factors or failure mechanisms in reliability tests are somewhat different with respect to gold wire bonding which, using unchanged but not validated test conditions and duration requirements, may lead to non-ju... |
By analyzing the relative position between tool and workpiece in assemble model of finite simulation, and loading the tool with parallel motion and rotation, a finite element model based on trochoid motion is built. In order to reduce the simulation time and errors advanced meshing method was used to optimize the finit... |
We report how a nominally symmetric microfluidic junction can be used to sort all bubbles of an incoming train exclusively into one of its arms. The existence of this "filter" regime is unexpected, given that the junction is symmetric. We analyze this behavior by quantifying how bubbles modulate the hydrodynamic resist... |
ABSTRACT The SecA protein is present in all bacteria, and it is a central component of the general Sec-dependent protein export pathway. An unusual property of Mycobacterium tuberculosis is the presence of two SecA proteins: SecA1, the essential “housekeeping” SecA, and SecA2, the accessory secretion factor. Here, we r... |
Setting: Needle and Syringe Exchange Programme (NSEP) implemented by non-governmental organisations in Malaysia. Objectives: To determine enrolment, characteristics and retention in the NSEP of people who inject drugs (PWID) between 2013 and 2015. Design: Retrospective cohort study. Results: There were 20 946 PWID, wit... |
The mechanisms by which Ca2+ signals control both primary cell function and gene expression remain obscure. The general consensus is that cytoplasmic Ca2+ transients may propagate to the nucleus via the nuclear pore complex and coordinate transcription in a manner supported by direct release of Ca2+ into the nucleus fr... |
According to animal protection the transport and proceeding of slaughtering are a difficult topic to cope with. The section of people is often restricted to distrust and rejection. In order to achieve improvement we need laws which prescribe the transport standards in particular with regard to the duration of driving a... |
The article is devoted to the study of theoretical approaches to the interpretation of the essence of the category of human capital and the definition of conceptual provisions of strategic management of human capital in enterprises in modern economic conditions. The article considers the main provisions of traditional,... |
The separate influences of spatial density and housing quality on the behavior of captive animals are difficult to measure because the two factors are often intrinsically linked. Here, we recorded affiliative and agonistic behavior in adult sooty mangabeys in various housing situations, testing spatial density and hous... |
ABSTRACT Magnetic functionalized halloysite nanotubes (MNPs/HNTs) was prepared and their effective adsorption for methylene blue (MB) was illustrated. Initially, poly(glycidyl methacrylate) grafted magnetic nanoparticles (MNPs-g-PGMA) were prepared by the reversible addition fragmentation chain transfer (RAFT) polymeri... |
Postpartum urinary retention is a common condition in obstetric units. A Clinical Practice Guideline was implemented in a high-risk obstetrical unit to decrease variance of clinical practice, rate of postpartum urinary retention, and number of urinary catheterizations and increase awareness of this common condition. Gu... |
An automatic system based on thermoelectric cooler (TEC), a microfan, and microcontroller is first applied to thermal management of high-power light-emitting diodes (LEDs). Its hardware is composed of microcontroller as a control core, K-type thermocouples as acquisition devices, and TEC and a microfan with heatsink as... |
ABSTRACT The authors argue that “true” models that aim at faithfully mimicking or reproducing every property of the sensorimotor system cannot be compact as they need many free parameters. Consequently, most scientists in motor control use what are called “false” models—models that derive from well-defined approximatio... |
Scene text detection is widely studied in natural language processing since 2016, in which arbitrary scene text detection is always the difficulty. At present, to deal with the problem of how to detect arbitrary shape text, the semantic segmentation-based methods are widely used, but the post-processing and label gener... |
Real-Time Strategy (RTS) games have become an increasingly popular test-bed for modern artificial intelligence techniques. With this rise in popularity has come the creation of several annual competitions, in which AI agents (bots) play the full game of StarCraft: Broodwar by Blizzard Entertainment. The three major an... |
'High-alert' medications and patient safety. |
This ‘Patient Safety Alert’ is the second in a series of periodic features in the Journal providing important information regarding the occurrence, management and prevention of sentinel events. A ‘sentinel event’ is an unexpected occurrence involving death or serious physical or psychological injury, or the risk of suc... |
Received 12.06.2018; accepted 25.07.2018; printed 30.09.2018; published online 05.10.2018 The objective of this study is the evaluation of the resistance of the bioindicative species Patella rustica Linnaeus, 1758 (Gastropoda Patellidae) existing in the contrasted sites of the Algerian occidental seaboard through a fol... |
Compressive sensing (CS) theory proves that signals can be recovered from far fewer random measurements than that suggested by Nyquist-Shannon theorem. This advantage of CS is extremely useful in some data processing applications, especially in video processing. Considering that nonlocal patch-based CS methodology has ... |
We analyze the information discrepancy between diagram- matic representations and logical reasoning, which we call visual biases in diagrammatic reasoning. Diagrammatic repre- sentations contain semantic information, which is based on the topological configurations of objects, and visual information, such as geometric ... |
segment to lower segment ratio 1.5:1(disproportionate short stature), weight 9 kg (<−3 SD, WHO) and head circumference 50 cm (normal for age). Her height age was 1.5 years. Mid parental height was 152 cm (−1 to −2 SD,WHO), whichwas far above the centile for her height. She had coarse dry skin. She was stout with promin... |
This paper presents investigations on the performance of 33 kV silicone rubber insulators characterized by different creepage lengths, which aimed to find out whether the insulators could permanently work when electrically stressed beyond the recommended limits in polluted and clean tropical environments. The study was... |
Living nature and human technology apply different principles to create hard, strong and tough materials. In this review, we compare and discuss prominent aspects of these alternative strategies, and demonstrate for selected examples that nanoscale-precision biotemplating is able to produce uncommon mechanical properti... |
The time of manifestation, severity and clinical course of atopic diseases are primarily determined by genetic factors. However, a number of environmental influences, like exposure to allergens and adjuvant trigger factors are modulating the clinical course. The risk for atopic disease can be predicted from cord blood ... |
This work is motivated by a quest for electronic nose sensors that are truly biomimetic. Following the vibration theory of olfaction, the inelastic electron tunneling (lET) spectra of odorant molecules for different receptor-odorant configurations have been calculated and analyzed. The effect of the combined shape of r... |
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