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The purpose of this article was to explore the psychosocial implications of being diagnosed with a high-grade glioma, World Health Organization III/IV and IV/IV, to better inform healthcare providers and researchers of the patient experience. The information is the cumulative data collected from hundreds of patient int... |
Remote sensing of atmospheric parameters with space-based passive microwave and optical sensors matured from research experiments in the 1960s and 1970s to operational systems in the 1970s and 1980s. Atmospheric temperature and humidity profiles can be retrieved using the infrared carbon dioxide resonances, the microwa... |
A new series of ETO device is proposed to improve the device parallel operation performance. The main concept of this device is to decouple the storage time dependency from the load current. By increasing the dynamic voltage pulse during the gate current commutation phase, the gate commutation time is significant reduc... |
Eight functional actin genes are present in Arabidopsis: The functional characterization of these genes in loss-of-function mutants is difficult, because highly conserved isovariants are generally expressed in the same tissue. We isolated a novel semi-dominant mutant allele (act2-2D) of an actin gene, ACT2, with a miss... |
The extensive investigation of the contribution of teachers to student achievement produces two generally accepted results. First, there is sub stantial variation in teacher quality as measured by the value added to achievement or future aca demic attainment or earnings. Second, variables often used to determine entry ... |
This article provides formulas for expected true-score measures and reliability of binary items as a function of their Rasch difficulty when the trait (ability) distribution is normal or logistic. The proposed formulas have theoretical value and can be useful in test development, score analysis, and simulation studies.... |
The orbital motion of Comet Wolf is investigated over the interval 1884-1976. In order to represent successfully the observations prior to 1925, nongravitational terms are required in the equations of motion. Mter a close approach to Jupiter in 1922 increased the perihelion distance of Comet Wolf from 1.6 to 2.4 astron... |
Digital CMOS is fast reaching its scaling limits. Nonetheless, CMOS will remain the backbone technology for building all computing functions. While attempts to extend the limits of CMOS will continue, there will also be increasing focus on other silicon technologies that are needed by system designers. For computing sy... |
An efficient stannylation process with N-tosylhydrazones or directly with carbonyl compounds has been developed. A series of functionalized benzyl- and alkyltributylstannanes can be synthesized in moderate to good yields under transition-metal-free conditions. Tandem transformations involving stannylation/Stille cross-... |
In the course of our antibiotic screening program several lincomycin-producing Streptomyces espinosus strains were isolated. These strains show a remarkable temperature dependence regarding the production of lincomycin. At incubation temperatures up to 28°C little or no lincomycin is produced despite good mycelial grow... |
Antagonistic actions of 4-aminopyridine (4-AP) and neostigmine methylsulfate (NSG) on the neuromuscular and cardiovascular depressions by kanamycin (KM) were studied in urethane anesthetized rats, in comparison with D-tubocurarine (D-Tc). Measured parameters were indirectly elicited twitch of tibialis anterior muscle, ... |
The multivariate phenotypic approach of natural selection suggests that selection can be adequately described by combining measurements of selection on phenotypic traits and estimates of heritabilities and genetic correlations (Lande and Arnold 1983). Under this framework (i.e., ignoring the consequences of pleiotropic... |
The evidence for an association between vitamin deficiency in early pregnancy and the prevalence of neural-tube defects in humans is reviewed, with particular emphasis on the methodological problems encountered in conducting such studies. It is apparent that there is strong evidence for an association between maternal ... |
The prion protein (PrP) binds Cu2+ ions in the octarepeat domain of the N-terminal tail up to |
full occupancy at pH=7.4. Recent experiments show that the HGGG octarepeat subdomain is |
responsible for holding the metal bound in a square planar coordination. By using first principle |
ab initio molecular dynamics simulations of the Car-Parrinello type, the Cu coordination mode |
to the binding sites of the PrP octarepeat region is investigated. Simulations are carried out for a |
number of structured binding sites. Results for the complexes Cu(HGGGW)+(wat), Cu(HGGG) |
and the dimer [Cu(HGGG)]2 are presented. While the presence of a Trp residue and a H2O |
molecule does not seem to affect the nature of the Cu coordination, high stability of the bond |
between Cu and the amide Nitrogens of deprotonated Gly’s is confirmed in the case of the |
Cu(HGGG) system. For the more interesting [Cu(HGGG)]2 dimer a dynamically entangled |
arrangement of the two monomers, with intertwined N-Cu bonds, emerges. This observation is |
consistent with the highly packed structure seen in experiments at full Cu occupancy.Attribution in International Investment Law |
Chapter III elucidates the application of attribution rules by international investment tribunals. This chapter is similar in structure to Chapter II, which is a consequence of the proximity of international investment law to public international law with regard to the topic of attribution of conduct to a party. In add... |
Sweet syndrome (SS) is a distinctive but poorly understood clinical syndrome, which likely represents an immunologic reaction pattern to a wide range of underlying or preceding conditions, including viral illnesses, inflammatory bowel disease, and malignancies. We report the case of a patient who presented with an acut... |
In this paper, multicarrier direct-sequence/slow-frequency-hopping (DS/SFH) CDMA systems are proposed, in which multiple carriers are modulated by the same DS waveform and hopped in frequency according to a hopping pattern. It is shown that the multicarrier DS/SFH systems are superior to the multicarrier DS systems in ... |
Laser thrombolysis uses microsecond laser pulses to remove thrombus-blocked arteries in the heart and the brain. Rapidly expanding and collapsing vapor bubbles are formed upon absorption of the laser energy by the thrombus. The goal of this study was to visualize the process of ablation and assess the effects of pulse ... |
UNLABELLED |
BACK AND STUDY AIMS: Endoscopic mucosal resection (EMR) is used to treat premalignant and malignant digestive tract lesions. This report presents the efficacy and safety of EMR for squamous superficial neoplastic esophageal lesions. |
PATIENTS AND METHODS |
A retrospective cohort study presented data from 51 patients with 54 lesions over an 8-year period, between November 1997 and September 2005. Dysplasas or mucosal (m) T1 carcinomas were treated with repeated EMR until there was a complete local remission. Patients with submucosal (sm) T1 carcinomas were treated with re... |
RESULTS |
There was no mortality, perforation, or major hemorrhage, and there were three easily dilated stenoses. Of the patients, 16 had lesions graded as T1sm or more advanced and one patient was found to have normal tissue post EMR. Complete local remission was achieved in 31 of the 34 patients with dysplasia or T1 m cancers ... |
CONCLUSIONS |
EMR for squamous superficial neoplastic lesions of the esophagus is safe and provides satisfactory survival results.Theoretical framework for comparing several popular stochastic optimization approaches |
This paper establishes a framework for formal comparisons of several leading optimization algorithms, establishing guidance to practitioners for when to use or not to use a particular method. The focus in this paper are five general algorithm forms: random search, simultaneous perturbation stochastic approximation, sim... |
Since their introduction in the late 1970s, sequential extraction procedures have experienced a rapid increase in use. They are now applied for a large number of potentially toxic elements in a wide range of sample types. This review uses evidence from the literature to consider the usefulness and limitations of sequen... |
We present a method for clustering short push-to-talk speech segments in the presence of different numbers of speakers. Iterative Mean Shift algorithm based on the cosine distance is used to perform speaker clustering on i-vectors generated from many short speech segments. We report results as measured by the Accuracy,... |
Computational fluid dynamics (CFD) simulations have emerged as a powerful tool for understanding the multiphase flows that occur in a wide range of engineering applications and natural processes. A multiphase CFD code called Multiphase Flow with Interphase eXchanges (MFIX) has been under development at the National Ene... |
Detection of plasma cells (PC) by flow cytometry is a problem because B lymphocytes gradually lose specific B-cell markers and surface-bound immunoglobulins during the differentiation pathway. In 1994 a monoclonal antibody (moAb), named B-B4 (CD138) and able to specifically mark PC among haemopoietic cells, was describ... |
Language can provide important insights into people, and culture more generally. Further, the digitization of information has made more and more textual data available. But by itself, all that data are just that: data. Realizing its potential requires turning that data into insight. We suggest that automated text analy... |
Acute myeloid leukemia (AML) is a clonal disease of hematopoiesis with poor clinical outcome despite recent improvements in chemotherapy and stem cell transplantation regimens. Immunotherapy with dendritic cells (DCs) eliciting specific T cell responses to leukemia-associated antigens (LAAs) might be a therapeutic opti... |
Abstract Surgical corrections of degenerative lumbar scoliosis and sagittal malalignment are associated with significant complications, such as rod fractures and pseudarthrosis, particularly in the lumbosacral junction. Finite element studies can provide relevant insights to improve performance of spinal implants. The ... |
CONTEXT |
Antimüllerian hormone (AMH) and insulin-like factor 3 (INSL3) represent ovarian functional markers of granulosa and theca cells, respectively. |
OBJECTIVE |
We conducted a prospective study to investigate AMH and INSL3 plasma levels in 3 groups of women with polycystic ovary syndrome (PCOS) classified according to menstrual cyclicity pattern and their relationship with ovarian morphology and hormonal levels. |
DESIGN AND PARTICIPANTS |
AMH and INSL3 were measured in a cohort of 57 patients with PCOS, divided into 3 groups according to menstrual status: eumenorrheic (PCOS-E, n = 15), oligomenorrheic (PCOS-O, n = 25), and amenorrheic (PCOS-A, n = 17). Clinical and endocrine characteristics and ovarian morphology were compared among the groups. Twenty-s... |
RESULTS |
According to the menstrual pattern, the women with PCOS-A and PCOS-O had higher INSL3 levels with respect to the control women (P = .025 and P = .004, respectively) and higher but not significant INSL3 levels compared with those of the women with PCOS-E. AMH levels were significantly higher in women with PCOS-A and PCO... |
CONCLUSIONS |
INSL3 and AMH levels are significantly correlated with each other in women with PCOS, and they are significantly increased, particularly in the presence of amenorrhea and oligomenorrhea. INSL3 and AMH may reflect a dysfunction of PCOS thecal and granulosa cells, which are responsible for the increased androgen producti... |
Over the conventional limit equilibrium method and limit analysis method, the finite element method is advantageous, especially for slopes involving complex failure mechanisms where the critical slip surfaces cannot be represented by log spirals and other similarities. In the presence of tension cracks at slope crests,... |
We studied the link between loss of E-cadherin-mediated adhesion and acquisition of malignant properties in three-dimensional, human tissue constructs that mimicked the initial stages of squamous cell cancer progression. Suppression of E-cadherin expression in early-stage, skin-derived tumor cells (HaCaT-II-4) was indu... |
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