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Pulmonary fibrosis was induced by bleomycin in C57BL/6 mouse (modeling group). The NF-κB antisense oligonucleotide was injected intravenously into mouse 6 hours before inducing (test group), we performed broncho-alveolar lavage and blood collecting through cardiac puncture. Bronchoalveolar Lavage Fluid (BALF) and serum... |
RESULTS |
The expression level of NF-κB and α-SMA were both consistently higher in modeling group when compared with control group (P < 0.05). Meanwhile, they were reduced significantly through the intervention of NF-κB p65 antisense oligonucleotide in the test group (P < 0.05). More importantly, the expression of NF-κB was posi... |
CONCLUSION |
our study suggests the potential in prevention of bleomycin-induced pulmonary fibrosis with NF-κB p65 antisense oligonucleotide.Simulation study on IRE ablation of breast tumors with multi-electrode |
Irreversible electroporation (IRE) can be used to ablate tumors when a high constant electric field is applied by using two-electrode or multi-electrode inserted in the tumors. The electroporation effect of biological tissue will make the electrical conductivity of biological tissue will increase with the increase of t... |
Evoked responses of the motor cortex (dendritic and slow negative potentials) elicited by its direct electrical stimulation, primary, nonspecific and antidromic responses elicited by stimulation of ventrolateral and intralaminar thalamic nuclei and pyramidal pathways and the respective postsynaptic responses of neurons... |
The discrimination of genuine and falsified emotional displays is critical in many contexts, including healthcare, forensic, and airport security settings. Previous research has demonstrated that comprehensive (two-day) empirically based deception detection training can lead to moderate gains in judgment accuracy. Howe... |
Solid state optical gyrometer is a novel integrated optical gyrometer which consists of a waveguide coil fully integrated on a substrate. The planar coil design implies waveguide crossings, so called X-junction. X-junctions are loss generating. In this paper, the power loss of X-junction is simulated by beam propagatio... |
This paper describes two applications of simulation modeling for outpatient clinics in a major urban medical center. The first application was developed for the Ear, Nose and Throat (ENT) Clinic where patients first see the physician and; when the physician requires a hearing test to be done immediately before a diagno... |
Clinical evaluation and kinetics in serum of cefoperazone (CPZ) in patients with lower respiratory tract infections have been conducted as a multicenter trial participated by 20 institutions in Kyushu area during a period of 8 months from October 1984 to May 1985. Mean serum CPZ levels up to 4 hours following the end o... |
Neuroinflammation is a complex pathological process usually results from abnormal microglial activation, thus, intervention in a microglial stimulation pathway could be a promising approach for the treatment of neurodegenerative diseases. Luteolin is an important bioflavonoid possesses anti-inflammatory properties, whi... |
The IEH graphs, a generalization of the hypercube, was introduced by Sur and Srimani [SI. It was shown that IEH graphs are incrementally extensible in steps of 1, optimally fault tolerant and its diameter is logarithmic in the number of nodes. Moreover, for any given number of nodes, the difference of the maximum and t... |
Colored asphalt concrete refers to asphalt concrete pavement that pigments are added in or colorful stones are mixed with, pigments added de-colored petroleum resin asphalt pavement, or modified asphalt pavement with water permeability sprayed with colorful resin coating. It is indispensable to develop traffic safety a... |
Background. Although a series of vaccines against Helicobacter pylori have emerged in the past 10 years, the mechanism involved in their protective effect is yet to be elucidated, and more effective vaccine adjuvants remain to be developed. In this study, CpG‐oligodeoxynucleotide (CpG‐ODN) was investigated as a new ca... |
Linyphiidae is the second largest family of spiders. Using Linyphia hortensis and L. triangularis, we describe linyphiid sheet‐web construction behaviour. Orb‐web construction behaviour is reviewed and compared with that of nonorb‐weaving orbicularians. Phylogenetic comparisons and the biogenetic law are applied to ded... |
The evolution of telecommunications and wireless technologies has brought in new sources of traffic data (particularly mobile data generated by vehicle probes), which could offer a breakthrough in the quality and extent of traffic data. This study reviews the Weather-Responsive Traffic Management (WRTM) models which we... |
This paper describes the novel network-based approach to a dictionary attack detection with the ability to recognize successful attack. We analyzed SSH break-in attempts at a flow level and determined a dictionary attack pattern. This pattern was verified and compared to common SSH traffic to prevent false positives. T... |
In an economic environment more global each day, a high percent of the employees in a company spend the most part of their work time outside their offices or even outside their countries. Advances in portable devices design and arrival of communication networks capable to transmitting such data allow these nomadic empl... |
OBJECTIVE |
To assess whether and how beverage companies incentivize universities to maximize sugar-sweetened beverage (SSB) sales through pouring rights contracts. |
METHODS |
Cross-sectional study of contracts between beverage companies and public U.S. universities with 20,000 or more students active in 2018 or 2019. We requested contracts from 143 universities. The primary measures were presence of financial incentives and penalties tied to sales volume. |
RESULTS |
124 universities (87%) provided 131 unique contracts (64 Coca-Cola, 67 Pepsi). 125 contracts (95%) included at least one provision tying payments to sales volume. The most common incentive type was commissions, found in 104 contracts (79%). Nineteen contracts (15%) provided higher commissions or rebates for carbonated ... |
CONCLUSIONS |
Most contracts between universities and beverage companies incentivized universities to market and sell bottled beverages, particularly SSBs. Given the health risks associated with consumption of SSBs, universities should consider their role in promoting them.SIGIR 2004 workshop: RIA and "where can IR go from here?" |
Current statistical approaches to IR have shown themselves to be effective and reliable in both research and commercial settings. However, experimental environments such as TREC show that retrieval results vary widely according to both topic (question asked) and system. This is true for both the basic IR systems and fo... |
Reducing body weight has been shown to lower blood pressure in obesity-related hypertension. However, success of those lifestyle interventions is limited due to poor long-term compliance. Emerging evidence indicates that feeding schedule plays a role on the regulation of blood pressure. With two studies, we examined th... |
Iron deficiency, without anaemia, is common in the general population and induces various symptoms. Its management consists of oral and intravenous supplementation for cases of inefficacy of or intolerance to oral iron. We assessed the efficacy of intravenous iron therapy in non-anaemic iron-deficient patients with fat... |
Introduction: The cerebral 5-HT system is phylogenetically old and shows remarkable anatomical resemblance among species. The goal of this review is to investigate the physiological role of 5-HT in the accomplishment of behavioral states. Tryptophan and 5-HT: In higher organisms, tryptophan is an essential amino acid a... |
This paper discusses fuzzy logic implementation in a load lifting arm robot. Fuzzy logic is used to calculate input values to avoid unsuitable power due to load weight variation. The evaluated performance on the load lifting robot is the successfulness of robot in lifting the load. System should determine the load mass... |
BACKGROUND |
To explore the regularity of abnormal telomeric associations in cellular chromosome of human lung cancer. |
METHODS |
The rate of telomeric associations was detected in human lung adenocarcinoma cell line A549 , peripheral blood lymphocytes in 15 patients with lung cancer , and in patients with non-cancerous diseases and normal adults as control by chromosome preparation assay. |
RESULTS |
A highly significant difference in the rate of telomeric associations was found between lung cancer group and control group ( P < 0. 005) . Human lung adenocarcinoma cell line A549 had the highest rate of telomeric associations in all groups ( P < 0. 005) . Moreover , there was significant difference in the rate of tel... |
CONCLUSIONS |
Compared with control group , human lung adenocarcinoma cell line A549 and lung cancer chromosome has higher telomeric associations and most of themoccured in idiogramB , idiogram C and idiogram D. It will provide worthwhile data of cell genetics for further research work on early diagnosis and prognosis in human lung ... |
We introduce a eukaryotic cellular system, the Xenopus laevis oocyte, for in-cell NMR analyses of biomolecules at high resolution and delineate the experimental reference conditions for successful implementations of in vivo NMR measurements in this cell type. This approach enables quantitative NMR experiments at define... |
We objectively identified an optimal number of atmospheric weather regimes, also called synoptic types, within the southwest (SW) Pacific tropical–subtropical domain and examined their potential drivers. Six atmospheric weather regimes in this region are characterized by spatially heterogeneous geopotential height, sea... |
Studies to elucidate changes in the contents of ulinastatin-like immunoreactive substance (UTIRS) and alpha 1-microglobulin-like immunoreactive substance (alpha 1 MIRS) in cerebrospinal fluid (CSF) of patients with dementia were performed. Levels of UTIRS in the dementia group were significantly (p < 0.01) lower than t... |
A revised fate map of the gastrula Xenopus embryo predicts the existence of patterning mechanisms that operate within the animal/vegetal axis of the mesoderm‐forming marginal zone. We review here molecular and embryologic data that demonstrate that such mechanisms are present and that they operate independently of the ... |
The role of component E of the DNA-dependent RNA polymerase of the archaebacterium Thermoplasma acidophilum in the transcription of Thermoplasma DNA has been analyzed. Component E (Mr 22000) is released upon formation of the binary complex of the polymerase with the DNA. Enzyme not containing component E is inactive on... |
The planning of the fixed part of the PCS network is mainly concerned with minimizing the investment costs of base station controllers (BSC) and PCS exchanges (PCX). Another important aspect which also needs to be considered simultaneously is to minimize the handoffs of CDMA cellular system. This paper describes a deta... |
Two hundred thirty-seven newly diagnosed yet untreated hypertensive men and women, 35 to 54 years of age, were compared with an age- and gender-stratified random population sample of 146 normotensive men and women to find out whether psychological distress symptoms, anger expression, and alexithymia are associated with... |
We consider a world in which the mode of food production, foraging or agriculture, is endogenous, and in which technology grows exogenously. Within a model of coalition formation, we allow individuals to rationally form cooperative communities (bands) of foragers or farmers. At the lowest levels of technology, equilibr... |
A number of studies have documented a relationship between creative self‐efficacy and creative performance. The main aim of the present study was to investigate organizational factors that may influence such creative self‐efficacy. The examined variables included employees' task type and task autonomy, the quality of r... |
New, cost effective fabrication processes for bonding and thinning silicon wafers for improving device performance and creating 3-D structures were investigated. Wafer bonding and de-bonding are key fabrication steps for many applications such as 3-D devices. Double bond transfer and single bond processes to fabricate ... |
It is very important for us to research the course of growing plants. The paper introduces an electro-optical measuring system to measure the geometry dimension of plant organs. And the system uses a new technology which can set a modern light, electricity, mechanical technology as one. The measuring principle is state... |
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