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METHODS |
We used a reduced Horne-Östberg Morningness-Eveningness Questionnaire (rMEQ) to survey UWTR participants for diurnal preference. Frequency and quantity of alcohol use, as well as binge drinking (6+ drinks per occasion), were assessed on a 5-point Likert scale. Both diurnal preference and alcohol use were self-reported.... |
RESULTS |
The sample consisted of 2,945 participants (mean age = 36.4 years), including 1,127 same-sex and opposite-sex twin pairs and 691 individual twins. The rMEQ range was 4-25, with a mean score of 15.3 (SD 4.0). Diurnal "morning types" comprised 30.7% (N = 903) of participants, while 17.4% (N = 513) were "evening types." R... |
CONCLUSIONS |
Genetic influences on diurnal preference confer elevated risk for problematic alcohol use, including increased quantity and binge drinking. Differences in circadian rhythm may be an important and understudied pathway of risk for genetic influences on alcohol use.Occurrence of pancreatic ductal cell dysplasia in rats fe... |
The effects of alcohol and diet on acute pancreatitis were studied in 192 male Wistar rats. The animals were fed with standard laboratory food up to three months of age and, after that, were divided into four groups of 48 animals, each group receiving a different diet: standard, fat-rich, protein-rich or carbohydrate-r... |
The authors describe a prototype geographically distributed, real-time multimedia communication system currently in everyday use at US West Advanced Technologies. To test it, nine of approximately 40 researchers in the Science and Technology Division have been relocated from the US West Advanced technologies headquarte... |
Background: Given the changes adolescents experience in psychosocial domains as they transition from childhood to young adulthood, the experience of cancer at this time of life is likely to differ in regard to symptom manifestation and relative distress. Objective: The purpose of this systematic review is to examine se... |
An ultra wide band two polarizations four ridge conical metal-dielectric feed horn has been proposed and investigated. The horn has a three-layer dielectric filling and is excited by a circular metal-dielectric waveguide, which is excited by two orthogonally located coaxial lines. Electrodynamic modeling and optimizati... |
The question of whether bacteriophage Mu prefers replication forks for lysogenic integration into Escherichia coli chromosomes was tested by using two different systems. In the first, inactivation of genes was scored in synchronized cultures infected by Mu at various times. No increase in the mutation frequency of a ge... |
This paper discusses approaches to teaching parts of the foundations of interactive narrative for the design of interactive media and games in a course offered to undergraduate New Media and Game Design students. The course is offered to upper division students, most of whom are in the Game Design degree in the School ... |
CONTEXT |
Women who rely on long-term hormonal contraception may neglect to use condoms, and thus increase their risk of contracting sexually transmitted diseases, including AIDS. |
METHODS |
Data from a prospective, multisite study were collected to examine the probability of condom use among 1,073 new users of either the contraceptive implant or injectable; users were interviewed when they accepted their method and again six months to one year later. Multivariate logistic regression analyses identified fa... |
RESULTS |
Condom use dropped markedly among women who adopted long-term hormonal contraception. The proportion who always used condoms in the previous three months fell from 21% at the time of adoption to 11% at follow-up. Among women with one sexual partner, this decrease was from 20% to 10%; however, among those with more than... |
CONCLUSIONS |
Although condom use among all women declined markedly once they initiated long-term hormonal contraception, frequency of condom use varied by subgroup and was associated with several factors. Most importantly, women with more than one sexual partner and those who received a message during counseling on the need to cont... |
Background: Hope is important to patients with cancer. Identifying factors that influence hope is important. Anxiety, depression, fatigue, and pain are reported to impair hope. The objective of this study was to determine whether age, gender, marital status, duration of cancer, symptoms, or symptom burden measured by t... |
Inactivation of a "tumor suppressor" gene could be a major cause of a class of blood cancers called diffuse large B-cell lymphomas, reports a team of researchers at the Weill Medical College of Cornell University. The discovery of the gene, called PRDM1, as a tumor suppressor sheds new light on the cause -- and possibl... |
Currently, no CAR-T product has been approved for use in China despite having hundreds of active CAR-T trials. Relma-cel (JWCAR029) is a CAR-T product with a CAR construct comprised of a binding domain, derived from a murine CD19-specific mAb (FMC63), a CD3ζ activation domain, and a 4-1BB costimulatory domain, and manu... |
Eligible adult patients had measurable, histologically confirmed r/r LBCL, failed at least 2 prior therapies, including anthracycline and anti-CD20 agents, and not had allogeneic transplant within 90 days or primary CNS lymphoma. Patients were randomized to receive either 100×106 (low dose) or 150×106 (high dose) CAR+... |
Between May 2018 and Dec 2019, 69 patients were screened, and 59 enrolled and treated with relma-cel, with median age of 56.0 years (18-75), 59.3% ECOG 1-2, and included several LBCL subtypes (DLBCL NOS 69.5%, TFL 15.3%, DHL/THL 5.1%, and PMBCL 6.8%) and nearly all with poor risk disease (81.4% treatment refractory, 4... |
Of 59 treated patients, grade ≥3 AEs occurring in >5% of patients were cytokine release syndrome (CRS), febrile neutropenia and lung infection (all, 5.1%). Grade ≥3 lab abnormalities in >10% of patients were neutrophil count decreased (30.5%), white blood cell count decreased (13.6%), leukopenia (10.2%) and neutropeni... |
The RELIANCE Trial provided the first demonstration of licensure-quality CAR-T manufacturing and clinical trial data generation in r/r patients originating in China. These results with relma-cel demonstrate similar preliminary response rates and PK profiles while providing the potential for an improved toxicity profil... |
Figure |
Zhang: JW Therapeutics (Shanghai) Co. Ltd: Current Employment, Current equity holder in private company. Yang:JW Therapeutics (Shanghai) Co. Ltd: Current Employment, Current equity holder in private company. Zhou:JW Therapeutics (Shanghai) Co. Ltd: Current Employment, Current equity holder in private company. Zheng:JW... |
Droplet-based microfluidic platform for high-throughput, multi-parameter screening of photosensitizer activity. |
We present a fully integrated droplet-based microfluidic platform for the high-throughput assessment of photodynamic therapy photosensitizer (PDT) efficacy on Escherichia coli. The described platform is able to controllably encapsulate cells and photosensitizer within pL-volume droplets, incubate the droplets over the ... |
Automatic estimation of pronunciation proficiency has its specific difficulty. Adequacy in controlling the vocal organs is often estimated from spectral envelopes of input utterances but the envelope patterns are also affected by alternating speakers. To develop a good and stable method for automatic estimation, the en... |
The present study investigates the combined impact of the intermittency associated with the turbulent-nonturbulent interface and the mean shear rate in an axisymmetric jet on the structure of turbulence in the scaling range, where the spectrum exhibits a power-law behavior. Second-order structure functions, autocorrela... |
In an Enterprise Resource Planning (ERP) system, production planning is influenced by a variety of parameters. Previous investigations show that setting parameter values is highly relevant to a company’s target system. Parameter settings should be checked and adjusted, e.g., after a change in environmental factors, by ... |
In the 1800s, the West was unknown to many. It was seen as less civilized and more dangerous than the East. As a result, people often referred to it as the “Wild West.” There were stories about the West that were exaggerated. If something happened in the West, the story and the facts would often change each time the st... |
Background: Locomotor system diseases are quite common in the field practice in dairy cattle and represent an important cause of economics losses. The rupture of the gastrocnemius muscle has been reported in humans, cattle, horses, camels and llamas. It can be complete or partial. The rupture of muscle as well as sacra... |
We estimate a model with latent factors that summarize the yield curve (namely, level, slope, and curvature) as well as observable macroeconomic variables (real activity, inflation, and the stance of monetary policy). Our goal is to provide a characterization of the dynamic interactions between the macroeconomy and the... |
Luminous radio sources are thought to lie in galaxy clusters or proto-clusters. The complete sample of 64 high-redshift 3C sources at $1 3\sigma$) within 30" ($\sim$250 kpc) projected distance from the radio source compared to the surrounding galaxy densities measured in the $50''-120''$ annulus. The Pan-STARRS/IRAC cu... |
The aim of this paper was to study the long term evolution of patients (one to five years) after an acute myocardial infarction. Three hundred and twenty questionnaires were sent to patients admitted and diagnosed as acute myocardial infarction in the private sector of the Instituto Nacional de Cardiología "Ignacio Chá... |
A favourite device of lecturers is to take a key word in the title of their speech and quote its definition from the pages of Webster's dictionary. Even though this may be mildly insulting to the audience—especially if the word being defined is something simple like “aviation”—it immediately gets the listeners onto the... |
Clinicians should take a mechanistic approach to transient ischemic attack and stroke. Distinguishing between hemorrhagic and ischemic stroke is important and is most readily accomplished with a computed tomographic brain scan. Newer diagnostic studies are now available to help evaluate patients for a cardiogenic sourc... |
Protein-polymer interactions are critical to applications ranging from biomedical devices to chromatographic separations. The mechanistic relationship between the microstructure of polymer chains and protein interactions is challenging to quantify and not well studied. Here single-molecule microscopy is used to compare... |
In this article, we present a general construction of Lyapunov–Krasovskii functionals for a class of neutral‐type time delay systems with a linear difference part and homogeneous right‐hand sides of degree strictly greater than one. Under an assumption that the corresponding difference matrix equation as well as a syst... |
Abstract This article examines how adolescents seek out help for their mental health problems by providing an overview of the research from the health and social service literature. The main goal of the paper is to explore the concept of adolescent's help-seeking in relation to the foster care experience. Two models of... |
Powered exoskeletons can facilitate after-stroke rehabilitation of patients with shoulder disabilities. Designs using serial mechanisms usually result in complicated and bulky exoskeletons. This paper presents a new parallel actuated shoulder exoskeleton that consists of two spherical mechanisms, two slider crank mecha... |
Radioactive test substances were infused slowly into the duodenum of conscious rats via a permanent catheter starting 2, 12 and 24 h after a standardized laparotomy. Two differently labelled but otherwise identical test substances were used. The first test substance (125I-PVP) was infused for 4 h, the second (131I-PVP)... |
Inverter based distributed generators are increasingly being employed for feeding energy from renewable energy sources into the grid. The control of parallel inverters in a microgrid system can fall under: centralized (involving communication), decentralized (droop control) or distributed (sparse communication network)... |
The control of women's sexuality is a theme that is insufficiently integrated into socialist-feminist analysis. This paper attempts to suggest some ways in which the control of women's sexuality is inherent in women's status in reproduction and production and hence in women's subordination. It starts with a cross-cultu... |
The direct effects of aldosterone and other mineralocorticoids on vascular smooth muscle were evaluated in isolated rabbit ear artery and aorta preparations. In the ear artery, aldosterone alone produced only a minimal effect. However, if desipramine, a blocker of neuronal norepinephrine uptake, was first placed in the... |
The current research explores different factors affecting individuals' support for airports implementing environmentally-friendly programs. Using social identity theory, the researchers manipulated participants' identification with one of the two major political parties to explore the relationship between political aff... |
This article reflects on my experiences observing and participating in the development of risk analysis for environmental and health hazards since the 1970s with emphasis on its critical role in informing decisions with potentially high consequences, even for very low probability events once ignored or simply viewed as... |
The work presents the data obtained in analysis of the epidemic situation among the population of Omsk in January-February 1985 and the characterization of the isolated strains of influenza A (H3N2) virus, determines the specific features of the course of the influenza epidemic process among different social and age gr... |
The increasing Chinese naval presence in and around Indian ocean, coupled with the rise of the home-grown Indian Navy and the US naval dominance over the global commons, has brought about a strategic maritime triangle in the Indian Ocean. This article looks into the evolving role, capacity and objectives of the Indian,... |
Thresholds for detecting change of angular size were determined for a range of angular separations in young and elderly observers. We found no differences in thresholds between these subject groups. Thresholds for detection of change of visual angle increased with angular separation in a power function relationship. An... |
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