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ITPV significantly improved CO2 removal in newborn lambs with diaphragmatic hernias without increasing airway pressures or changing oxygenation. Based on these results, we are conducting human clinical trials.Who are the Policy Workers and What Are They Doing? Citizen's Heuristics and Democratic Accountability in Compl... |
Two critical questions for the study of accountability in contemporary governance can focus attention on the citizen, rather than the official. I begin with the question of whether a citizen can identify a policy worker — that is, the bureaucrat, contractor, or other actor acting in pursuit of a legislated policy goal.... |
Assessment of the evolutionary process is crucial for understanding the effect of protein structure and function on sequence evolution and for many other analyses in molecular evolution. Here, we used simulations to study how taxon sampling affects accuracy of parameter estimation and topological inference in the absen... |
Pelvic injuries are an important issue in trauma patients, largely as a result of the major disruptive forces required to fracture the pelvic ring. Despite the growing influence of more sophisticated techniques such as CT and MR in the evaluation of pelvic trauma, conventional imaging remains important, especially in t... |
Residential magnetic field (MF) measurements were performed for the first time in a representative sample of French dwellings. Exposure levels were assessed by two methods: indoor and outdoor measurements. Linear and logistic regression models were used to determine factors associated with the time-weighted average (TW... |
Nowadays, the transition to a more sustainable energy and transport system is necessary. Smart City and districts, through the integration of technologies such as Renewable Energy Sources (RES) and Electric Vehicles (EVs) represent the future of the urban landscape. This work faces this theme at a district level, consi... |
This paper reports the use of time resolved pulse discharge spectroscopy for detecting organic vapors in ambient air. The impact of both sample duration and delay is investigated. A pulsed micro-discharge, consuming only 400 µJ of energy, is struck by applying a high voltage pulse between two closely spaced electrodes ... |
Insomnia disorder is an economic burden and public health concern affecting up to one-third of the population of the United States. It is mostly seen in older age groups, and often considered a normal aging phenomenon. The diagnosis and treatment of insomnia rely mainly on a thorough sleep history to address the precip... |
The annual risk of stroke in patients with symptomatic carotid artery occlusion (CAO) and impaired cerebral blood flow (CBF) is approximately 10%. Increased oxygen extraction fraction measured by positron emission tomography (PET) and low cerebrovascular reactivity assessed by transcranial Doppler is associated with an... |
Background and Aim: Diabetes mellitus is an endocrine disorder characterized by metabolic abnormalities, which has been reported to be associated with cognitive dysfunctions. Exercise along with diet and medication has been considered as a cornerstone in the management of type 2 diabetes mellitus (T2DM). Therefore, the... |
Pots experiment was conducted in the experimental farm of Agricultural Botany Department, Faculty of Agriculture, Ain Shams Univ. during the seasons of 2015 and 2016 to investigate the effect of grafting on salt tolerance of watermelon plants. Watermelon (Citrullus lanatus, Hybrid F1) Aswan1 was grafted onto the rootst... |
We describe a simple multiplex vibrational spectroscopic imaging technique based on employing chirped femtosecond pulses in a coherent anti-Stokes Raman scattering (CARS) scheme. Overlap of a femtosecond Stokes pulse with chirped pump/probe pulses introduces a temporal gate that defines the spectral resolution of the t... |
Stanford University students have successful built several small satellites already. CubeSat is advocated as another student built satellite with 100 mm cube shape (hence the name) and 1 kg mass. NASA Ames Research Center will use the satellite equivalent to size of six CubeSats for highly miniaturized autonomous cell-... |
Echinococcus multilocularis is a parasite species of zoonotic importance which can be fatal to humans and causes Alveolar Echinococcosis (AE). This report describes the development of a cyst from the liver of a wild boar and molecular confirmation of its identification. The cyst material was obtained from the liver of ... |
Abstract: To study the level of ciliary neurotrophic factor (CNTF) in human nervous tissues, we developed a sensitive enzyme‐linked immunoassay using a specific antibody against human CNTF. This method allowed us to detect as little as 0.3 ng/ml of human CNTF with good linearity and accuracy. Using this method, CNTF le... |
The goal of this paper is to compare and investigate the radiation attenuation properties of Mundrabilla and NWA 7629 meteorites in terms of the photon, fast neutron and charged particles. The linear attenuation coefficients of Mundrabilla are higher than those of NWA 7629. The half value layers, tenth value layers and... |
237 out-patients suffering from chronic obstructive lung disease (COLD) were selected from 7 Italian clinical centers. They were randomly allocated to either placebo or bromhexine 30 mg b.i.d. p.o., in a double-blind fashion. Sputum volume and quality, facility of expectoration, cough, dyspnea, auscultatory thoracic sy... |
Educational assessments occasionally require uniform test forms for which each test form comprises a different set of items, but the forms meet equivalent test specifications (i.e., qualities indicated by test information functions based on item response theory). We propose two maximum clique algorithms (MCA) for unifo... |
Bacteria play host to a wide range of protein phosphorylation-dephosphorylation systems (Fig. 1). As little as five years ago the known systems were thought to be late-emerging and absolutely prokaryote specific. Today we know that most protein kinases and protein phosphatases are descended from a set of common, and po... |
IN A RECENT PUBLICATION the Metropolitan Museum reproduced in facsimile, together with an explanatory volume, an early fourteenth-century manuscript, the so-called Cloisters Apocalypse (acc. no. 68.I74). The illustrations in this manuscript show a startling relationship to the three miniatures by the Master of the Thir... |
It is naive and incorrect to use the proportions of successful operations to compare the performance of surgeons because the patients' risk profiles are different. In this paper, we explore the use of risk‐adjusted procedures to compare the performance of surgeons. One such risk‐adjusted statistic is the standardized m... |
Abstract Throughout the Ediacaran Period, variable water-column redox conditions persisted along productive ocean margins due to a complex interplay between nutrient supply and oceanographic restriction. These changing conditions are considered to have influenced early faunal evolution, with marine anoxia potentially i... |
Insomnia affects 10–20% of the US population and is associated with negative health and psychosocial sequelae. Despite the public health impact of insomnia little is known about its underlying molecular mechanisms. The purpose of this study is to examine differentially expressed genes in 15 patients with chronic insom... |
We performed total RNA-seq on 30 whole blood samples collected at 09:00 at 150 bp paired-ends on the Illumina NovaSeq-6000 platform. Alignment was performed using the STAR version 2.7.2a software on the human reference genome (GRCh38). Differential gene expression analysis was performed using DESeq2 version 1.24.0. Pa... |
An average of 86.7 million paired end reads per sample were sequenced. We found that 289 genes were differentially expressed in insomnia patients with a log fold change (LFC) ±0.50 and had a FDR p-value < 0.05. Top dysregulated genes include CSMD1 (L2FC=-2.78; p=1.35E-06), DUX4L9 (L2FC=3.40; p=2.81E-06) and GRM4 (L2FC... |
Overall, our study revealed dysregulated genes in individuals who suffer from insomnia. Notably, dysregulation of these functionally relevant genes could impair functional brain connectivity and synaptic function. Further investigation of these biological pathways will be useful to elucidate the pathogenesis of insomn... |
National Institutes of Nursing Research, Graduate Partnership Program |
[The resting-state functional connectivity of the hypothalamus and its relationships with gonadal steroid hormones and depression symptoms in perimenopausal women]. |
OBJECTIVE |
This study aimed to investigate the resting-state functional connectivity of the hypothalamus and its relationships with gonadal steroid hormones and depression symptoms in perimenopausal women. |
METHODS |
Total 66 perimenopausal women voluntarily participated in this study from October 2012 to June 2013. Zung Self-rating Depression Scale (ZSDS) was used to assess depression symptoms. Plasma gonadal steroid hormones including estradiol, testosterone, and progesterone were determined by the chemiluminescence immunoassay. ... |
RESULTS |
Significant functional connectivity to the hypothalamus were found in brain areas as follows:the lateral inferior frontal gyrus, medial prefrontal cortex, dorsal lateral prefrontal cortex, orbitofrontal cortex, subgenual cortex, anterior cingulate cortex, posterior cingulate cortex, cuneus and precuneus, hippocampus an... |
CONCLUSION |
In perimenopausal women, the hypothalamus has resting-state functional connectivity with widespread areas involved in the brain depression-related network and default mode network, and the plasma androgen level may modulate the functional connectivity strengths of the hypothalamus and decrease the susceptibility of per... |
We have isolated a full-length mouse B-myb cDNA clone and used this to examine cell cycle-regulated expression of this gene. Mouse B-Myb was predicted to comprise 704 amino acids and to be 84% homologous with human B-Myb. There were three regions of extensive amino acid homology which may indicate functional domains: t... |
To the Editor. —I wish to comment on, as well as take exception to, some of the data in the article by Kraushar and Turner. 1 In a group with identical numbers of claims in Louisiana, which were reviewed by a medical review panel, approximately 85% were decided in favor of the health care provider. However, in New Jers... |
Excess hair is an age‐old condition plaguing both men and women alike, of all races. Conditions such as hirsutism or hypertrichosis, procedures that involve grafted donor sites, transsexual transformations from male to female, and genetics are all responsible for excess or unwanted hair. Previous options for people see... |
Maternofetal infection occurs in 1 to 10 of every 1,000 newborns. Prognosis is poor and an extremely rapid the clinical course is sometimes observed. The situation suggests that widespread use of antibiotics and more than 90% of the newborns receiving antibiotics are not infected. A prospective study based on simple, r... |
Part 1 The beginnings of civilization: digging up the past hunters, artists and farmers the fertile crescent. Part 2 Mesopotamia: summer and Babylon Assyrians and Persians. Part 3 Egypt: the tomb of Tutankhamen Egyptian life and customs. Part 4 India and China: lost cities of the Indus the Chinese. Part 5 The Americas:... |
Abstract Chemodynamical disc galaxy simulations calibrated with stellar populations synthesis models allow to build mock multi-wavelength images from numerical simulations. The morphological evolution of the mass and colour distributions can thus be simultaneously followed. We present the evolution of the stellar disc ... |
The complexities of process plants are increasing because of process integration and plant-wide optimization. Failure models of a process system (henceforth referred to as process-accident models) should be able to capture the inherent dependence among process components and their associated variables and also the temp... |
A coating must remain intact to perform its inherent functions on a surface, and often functional organic coatings fail due to deterioration because of their intrinsic vulnerabilities. In this work, we present a biomimetic material based on a glass sponge to provide a robust silica composite nanocoating with an anti-fo... |
This study challenges Samuel Huntington’s well-known clash of civilizations paradigm based on a philosophical reasoning of cognitive proofs. The authors propose the clash of perceptions, an alternative paradigm that better reflects the complexity of individual and collective interactions. Building on case studies and r... |
The plasma membrane (PM) contains an asymmetric distribution of lipids between the inner and outer leaflets of its bilayer. A lipid of special interest in eukaryotic cells is the negatively charged phosphatidylserine (PS). In healthy cells, PS is actively sequestered to the inner leaflet of the PM but can redistribute ... |
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